CN107271686B - 使用质谱检测至少一种碳青霉烯抗性机制的方法 - Google Patents

使用质谱检测至少一种碳青霉烯抗性机制的方法 Download PDF

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CN107271686B
CN107271686B CN201710564085.XA CN201710564085A CN107271686B CN 107271686 B CN107271686 B CN 107271686B CN 201710564085 A CN201710564085 A CN 201710564085A CN 107271686 B CN107271686 B CN 107271686B
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Y·沙勒捷
J-P·沙里耶
C·弗兰切斯基
G·赞巴尔迪
T·切基尼
E·德古沙尔梅特
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Abstract

本发明涉及通过质谱检测样品中至少一种微生物针对至少一种抗菌剂的至少一种抗性标记的方法，其特征在于抗菌剂是碳青霉烯，且所述抗性标记是蛋白质或肽。优选地，所述蛋白质或肽是来自所述微生物的蛋白质。

Description

使用质谱检测至少一种碳青霉烯抗性机制的方法
本申请是申请日为2012年4月20日的第201280030179.4号发明名称为“使用质谱检测至少一种碳青霉烯抗性机制的方法”的中国专利申请的分案申请。
本发明涉及微生物学领域。更精确地说，本发明涉及用质谱检测样品中至少一种微生物对碳青霉烯抗性的至少一种机制的方法。
自从巴斯德发现了微生物以来，微生物体以显微镜和生化分析来研究。这些传统的方法通常冗长乏味，因此很久以来一直在寻找其他分析方法。这就是为什么J.Anhalt和C.Fenselau从1975年起发起了以质谱分析细菌[1]。
随着这一初步工作，气相色谱与质谱联用的方法被用于微生物细胞壁中脂肪酸的研究[2]。这项技术广泛采用的英语术语是FAME，即脂肪酸甲酯(Fatty Acid MethylEster)。现在成为一种分类学研究的参考方法。尽管如此，它的应用局限于某些特定的以皂化、水解和分离的方法处理样品的实验室。
在1996年，M.Claydon等[3]以及T.Krishnamurthy和P.Ross[4]的工作证明可以用MALDI-TOF(矩阵辅助的激光解吸离子化-渡越时间，Matrix Assisted Laser DesorptionIonization–Time Of Flight)质谱鉴别不同的细菌种。该分析结合了获取质谱和解释专业软件。十分简单并且可以在几分钟内得出结果。尽管如此，现在还只是应用在药物分析的实验室[5]。其临床应用现在还局限于鉴别细菌和酵母的种类，还没有常规应用于鉴别抗菌剂抗性。
为了保证最优化的病患护理，对诸如抗生素等抗菌剂的抗性的鉴别是重要的要素。
推荐其他质谱方法，特别是串联质谱，以满足这些需要。例如，可以引用C.Fenselau等关于用四极子-TOF(Q-TOF)鉴别β-内酰胺酶的工作[6]。
尽管如此，这些研究结果是通过通过研究仪器获得的，要求高素质的人员，无法应用于日常临床。通常大于1小时/样品的分析时间与微生物分析实验室的工作量是不相容的。
最近，S.Hofstadler等[7]提出了一种结合PCR扩增微生物基因组和电喷射-TOF(ESI-TOF)检测PCR产物的方法。这种方法现在是全自动的[8]。尽管如此，它要求PCR扩增，其具有分子生物学固有的瑕疵，即提取产量，探针成本等问题。
在这一背景下，本发明的目的在于提出一种检测碳青霉烯抗性机制的方法，以克服现有技术的不足，也就是提供一种廉价的方法，特别是与分子生物学相比，不使用每个种特异的试剂，在短时间内(少于1小时)得出结果，不要求高素质人员而能够应用于日常临床。
为了这个目的，本发明提出了一种通过质谱检测样品中至少一种微生物对至少一种抗菌剂的至少一种抗性机制的新方法，其特征在于：抗菌剂是碳青霉烯；以及检测针对至少一类碳青霉烯抗生素的所述抗性机制的标记是蛋白质和/或多肽。
优选地，抗性标记是来自于所述至少一种微生物的蛋白质。有利的是，几种不同抗菌剂的抗性标记可以同时检测。
如PCT/FR2010/052181中所示，在检测抗性机制标记之前或同时，所述微生物的类型和/或毒力标记能够通过质谱以相同的方法检测。
至少一种碳青霉烯类抗菌剂的抗性标记理解为以所述性质为特征的蛋白质来源的分子。碳青霉烯是属于β-内酰胺家族的抗生素，其主要代表是亚胺培南、美罗培南、厄他培南和多利培南。这些分子被Bush和Jacoby分类的β-内酰胺酶2df、2f和3a分解([9]，Antimicrobial Agents and Chemotherapy,2010；54(3):969-976)。
确定对至少一种抗菌剂的抗性理解为确定微生物被抗菌剂杀死的敏感性。当科和种不同时抗性机制涉及的蛋白也将不同。
β-内酰胺酶——β-内酰胺抗性细菌酶——的命名法未标准化。既根据一级结构分为四类(A到D)，也按照靶底物和对抑制剂的抗性功能性分组(作为概述，见前述Bush andJacoby[9])。对分子分类，测序技术使更精确的分类成为可能：例如，已经描述了TEM蛋白的183种变体(标记为TEM-i，i从1到183)。对于功能性分类，前述Bush and Jacoby提出了新的功能性亚组：
-第一组酶是属于C类分子的头孢菌素酶。CMY和FOX是质粒携带的酶，属于这个亚组。
-第二组酶属于A类和D类分子。这个组自我再分为亚组2b、2be、2br、2ber、2d、2de、2df、2f等。CTX-M(2be)和TEM(包括2be、2br)是属于这个亚组的酶。2b亚组对应被克拉维酸、sulfobactam或三唑巴坦抑制的广谱的β-内酰胺酶。2be亚组对应同样也被克拉维酸、sulfobactam或三唑巴坦抑制的超广谱的β-内酰胺酶(ESBL)。2br亚组对应2b亚组中对克拉维酸、sulfobactam或三唑巴坦的抑制不敏感的β-内酰胺酶。2bf亚组包括对碳青霉烯超广谱的OXA。2f组对应碳青霉烯酶β-内酰胺酶，例如KPC。
-第三组包含水解碳青霉烯的金属-β-内酰胺酶，例如IMP、VIM、SPM、GIM、SIM、AIM、KHM、DIM或NDM。
NDM-1β-内酰胺酶于2010年被描述(Kumarasamy et al.,2010,LancetInfect.Dis.,10:597-602)。相当于一种金属-β-内酰胺酶，赋予对除氨曲南外所有β-内酰胺的抗性。
KPCβ-内酰胺酶于2001年在美国被描述(Yigit et al.,2001,Antimicrobio.Agents Chemother.,45:1151-1161)，随后遍及世界。相当于A类β-内酰胺酶，赋予对头孢菌素和碳青霉烯的抗性，尤其是对亚胺培南和美罗培南。
IMPβ-内酰胺酶于1994年在日本被描述(Osano et al.,1994,Antimicrobio.Agents Chemother.,38:71-78)，随后遍及世界。相当于金属-β-内酰胺酶，赋予对头孢菌素和碳青霉烯的抗性，但是对替莫西林和氨曲南无效。
VIMβ-内酰胺酶与1999年在欧洲被描述(Lauretti et al.,1999,Antimicrobio.Agents Chemother.,43:1584-1590)，随后遍及世界。相当于金属-β-内酰胺酶，赋予对头孢菌素和碳青霉烯的抗性，但是对氨曲南无效。
第一个GESβ-内酰胺酶与1998年在法属圭亚那被分离(Poirel et al.,2000,Antimicrobio.Agents Chemother.,43:622-632)。这种酶(GES-1)赋予ESBL抗性。从耐受GESβ-内酰胺酶的细菌的第二次分离于2000年在南非完成(Poirel et al.,2001,Antimicrobio.Agents Chemother.,45:2598-2603)。这种酶(GES-2)赋予对诸如亚胺培南的头孢菌素和碳青霉烯的抗性。
INDβ-内酰胺酶首次描述于1999年(Bellais et al.,1999,FEMSMicrobio.Lett.,171:127-132)。相当于金属-β-内酰胺酶，赋予对头孢菌素和碳青霉烯的抗性。
SMEβ-内酰胺酶首次描述于1994年(Naas et al.,1994,Antimicrobio.AgentsChemother.,38:1262-1270)。相当于A类β-内酰胺酶，赋予对头孢菌素和碳青霉烯的抗性。
OXAβ-内酰胺酶(或oxacillinases)对应D类β-内酰胺酶。根据其的初级序列，其能够赋予对头孢菌素或对头孢菌素和碳青霉烯的抗性(Poirel et al.,2010,Antimicrobio.Agents Chemother.,54:24-38)。
本发明的方法可以用于检测细菌中对于碳青霉烯的抗性机制。因此，例如，可以根据本发明的方法在其中找到对碳青霉烯的抗性机制的细菌的非穷举性实例有：大肠杆菌(Escherichia coli)、肺炎克雷伯菌(Klebsiella pneumoniae)、绿脓假单胞菌(Pseudomonas aeruginosa)、鲍氏不动杆菌(Acinetobacter baumannii)、芽孢杆菌(Bacillus spp)、嗜麦芽寡养单胞菌(Stenotrophomonas maltophilia)、气单胞菌(Aeromonas spp)、脆弱拟杆菌(Bacteroides fragilis)、假单胞菌(Pseudomonasotitidis)以及阴沟肠杆菌(Enterobacter cloacae)，更广泛地说，携带blaNDM-1或blaKPC抗性基因的肠杆菌科(Enterobacteriaceae)微生物。应该进一步注意的是已知抗碳青霉烯的菌株也对头孢菌素和青霉素有抗性。
因此，根据本发明的方法也使检测对所述抗生素的抗性机制成为可能。
本发明的方法可以应用的样品是任何容许含有靶微生物的样品。样品可以是生物学来源的，无论是动物，蔬菜还是人。在这个实施方式中，相当于生物流体样品(例如全血、血清、血浆、尿液、脑脊液、组织分泌物)、组织样品或者分离的细胞。在细菌β-内酰胺抗性机制的标记能够用于检测或者在分析前可以进行富集、提取、浓缩、纯化、培养等根据本领域技术人员已知的方法制备的样品可以使用。
样品可以是工业来源或者根据非穷举的列表可以是空气样品、水样品、表面样品、制成品的一部分或者食物产品。在食物样品中，简单来说，可以包括乳制品(酸奶、奶酪)样品、肉、鱼、蛋、水果、蔬菜、水、饮料(牛奶、果汁、苏打水等)。这些食物样品还可以来自酱或即食餐。最后，食物样品可以来自动物饲料，例如动物膳食。
在质谱检测的上游，优选地，待分析的样品经过预处理使样品中存在的完整蛋白质片段化而产生多肽，例如用蛋白酶消化或化学试剂反应。事实上，裂解蛋白质可以通过物理化学、生物学或者两者结合处理来实现。在可用的处理中，可以提及以羟自由基处理，特别是H2O2。羟自由基处理导致肽键的切开在任何蛋白质的肽键位置随机发生。羟自由基浓度决定裂解数，以及所得到的肽段的长度。还可以用其他化学处理，例如特异性在甲硫氨酰残基羧基处切开肽键的溴化氰(CNBr)处理。也可以在三氟乙酸中加热蛋白质溶液到1000℃进行天冬氨酰残基上的部分酸裂解。
尽管如此，酶解处理蛋白优先于物理化学处理，因为其更能保护蛋白结构并且更易控制。“酶解”意味着一个或者多个酶在正确的条件下单独或联合的反应。实施蛋白水解的酶，即蛋白酶在特定位置切割蛋白。每种蛋白酶一般识别一种氨基酸序列，并总是进行同样的切割。某些蛋白酶识别一个氨基酸或两个氨基酸的序列并在其间裂解，而其他蛋白酶只识别更长的序列。这些蛋白酶可以是内切蛋白酶或外切蛋白酶。在已知的蛋白酶中，包括如在WO2005/098071中描述的：
-特异性酶，例如胰蛋白酶(trypsin)在Arg和Lys的羧基处切断肽键，细胞内溶素(endolysin)在赖氨酸羰基处裂解肽键，糜蛋白酶(chymotrypsin)在芳香残基(Phe、Tyr和Trp)羧基处水解肽键，胃蛋白酶(pepsin)在芳香残基(Phe、Tyr和Trp)氨基处切割，来源于Staphylococcus aureus V8菌株的蛋白酶V8在Glu残基羧基处裂解肽键；
-非特异性酶，例如来自细菌Bacillus thermoproteolyticus的嗜热菌蛋白酶(thermolysin)在疏水氨基酸(Xaa-The、Xaa-Ile、Xaa-Phe)氨基端水解肽键，属于细菌蛋白酶的枯草杆菌蛋白酶(subtilisin)和链霉蛋白酶(pronase)实际上水解所有肽键并能在控制的反应条件(酶浓度和反应时间)下把蛋白转化成寡肽。
如果反应模式可以兼容，有些蛋白酶可以同时或相继使用。在本发明范围内，样品的消化优选的由蛋白酶执行，例如胰蛋白酶。
用化学试剂或蛋白酶产生多肽能通过溶液中简单反应的方法实现。还可以通过微波炉[10]或高压[11]，甚至使用超声仪器[12]实现。在后面的三个实施方式中，方案快了很多。
在如此获得的多肽中，蛋白特异性的多肽被称为蛋白质代表性(proteotypic)肽，也就是将要被质谱分析的。
根据本发明细菌对碳青霉烯的抗性机制标记是来自可以在其中找到抗碳青霉烯机制的细菌的蛋白。尤其是，所述蛋白被优选地使用酶，更优选地使用胰蛋白酶消化成多肽。
相似的是，含有细菌抗碳青霉烯机制特征性蛋白标记的样品可以预处理以达到纯化的目的。纯化预处理可以在如上所述的多肽产生步骤之前或之后进行。
样品纯化处理在本领域技术人员中是众所周知的，尤其是采用离心、过滤、电泳或层析技术。这些分离技术可以单独使用或者彼此联用以获得多维的分离。例如，多维层析可以如T.Fortin等[13]或H.Keshishian等[14]所述，通过离子交换层析和反相层析的联用来实现。在这些文章中，层析介质可以是柱或者筒(固相萃取)。蛋白质代表性肽的电泳或层析级份(或一维或多维层析的保留时间)是每种肽的特征，因此采用这些技术使选择蛋白质代表性肽或多肽进行分析成为可能。这样区别产生的多肽可以增加后续质谱分析的特异性。
目的在于分离多肽的电泳或层析技术的一个变形在于特异性纯化N-糖肽([15]以及专利申请WO 2008/066629)。尽管如此，这样的纯化只可以定量进行了N-糖基化的翻译后修饰的多肽。不是所有的蛋白都会糖基化，这限制了其应用。
作为分析和检测不同类型分子的有力工具，用于本发明方法的质谱是本领域技术人员所共知的。一般来说，任何可以被电离的分子都可以根据其分子量由质谱仪检测。根据被测分子的自然状态，无论蛋白还是代谢源，某些质谱技术会更合适。然而，无论用质谱方法检测什么，后面都包括把靶分子电离为所谓分子离子的步骤，即本实施方式中，电离特征标记的步骤和分离质谱获得的分子离子的步骤。
因此，所有的质谱包含：
-用于电离待分析样品中存在的标记的电离源，即给予这些标记正或负电荷；
-用于根据其荷质比分离电离标记或分子离子质量分析仪；
-用于测量分子离子直接产生的信号或以后述方法自分子离子产生的离子的检测仪。
电离步骤(采用质谱所必需的)可以通过任何本领域技术人员已知的方法进行。电离源可以使待分析分子转化成气态的并且电离的状态。电离源可以用正电荷模式研究阳离子，或者负电荷模式研究阴离子。存在几种类型的电离源，可基于要寻找的结果和要分析的分子使用这些电离源。尤其是包括：
-电子电离(EI)、化学电离(CI)和解吸化学电离(DCI)；
-快原子轰击(FAB)、亚稳态原子轰击(MAB)或离子轰击(SIMS，LSIMS)；
-电感耦合等离子体(ICP)；
-大气压化学电离(APCI)和大气压光电离(APPI)；
-Electronebulisation或点喷射(ESI)；
-矩阵辅助激光解吸/电离(MALDI)、表面活化激光解吸/电离(SELDI)或硅解吸/电离(DIOS)；
-与亚稳态种相互作用的电离/解吸(DART)。
具体而言，电离进行如下：把含有靶分子的样品导入电离源，在此分子在气态下被离子化并转化成对应最初分子的分子离子。电喷射电离(ESI)源可以通过使分子从液态逐渐变气态而电离。在正电荷模式中，如此得到的存在于液相中的对应于分子的有1、2甚至3或者更多的额外质子的分子离子带有1、2甚至3或者更多的电荷。例如，当靶分子是一种蛋白，分离靶蛋白后获得的蛋白质代表性肽使用电喷射源在正电荷模式的电离产生气相的带1、2甚至3或者更多的额外质子多肽离子，其带有1、2甚至3或者更多的电荷，并可以从液相移动到气相[16]。这类源尤其适合先用反相液相色谱分离获得的靶分子或蛋白质代表性肽。然而，样品中存在的分子的电离得率(ionisation yield)会随着浓度和存在的不同物种的天然状态而改变。这一现象导致了本领域技术人员所周知的矩阵效应。
MALDI电离源可以使来自固态样品的分子电离。
根据荷质比分离离子化标记的步骤在质量分析器中进行，本领域技术人员公知的任何质量分析器都适用。其可以由低分辨率分析器、四极子(quadripole或quadrupole(Q))、3D离子陷阱(iron trap，IT)或线性离子陷阱(linear iron trap、LIT)也称离子陷阱、高分辨率分析器组成，高分辨率分析器使其可以测量被分析物的确切质量，并且特别使用了连接于扇形电场的扇形磁场、渡越时间(TOF)、傅里叶变换离子回旋加速(FT-ICR)、轨道阱。
依靠其荷质比的分子离子的分离可以只进行一次(单质谱或MS)，或者可以进行几次连续的分离。当执行了两次连续的MS分离时，该分析被称为MS/MS或MS2。当执行了三次连续的MS分离时，该分析被称为MS/MS/MS或MS3，一般地说，当执行了n次连续的MS分离时，该分析被称为MSn。
在使用了几次连续的分离的技术之中，检测或分析单一靶分子的选择反应监测(Selected Reaction Monitoring，SRM)模式，或者检测或分析数种靶分子的多反应监测(Multiple Reaction Monitoring，MRM)模式是MS2分离的具体应用。近似地，MRM3模式是MS/MS/MS分离的具体应用。这就称为靶向质谱。
在单MS模式检测的情况下，所得到的的分子离子的荷质比与待检测的分子有关。在MS/MS模式检测的情况下，与MS分析相比，基本上要添加两步：
-分子离子(后称为前体离子，precursor ions)的破碎，以产生所谓第一代碎片离子(fragment ions)，以及
-根据其与前体离子荷质比(m/z)相应的质量(m/z)2、比例(m/z)1分离所谓的第一代碎片离子。
因此，这样获得的第一代碎片离子的荷质比与待测的靶分子有关。第一代碎片离子是来源于前体离子，经过破碎步骤，并且其荷质比m/z不同于前体离子的一种离子。
(m/z)2和(m/z)1对被称为转换(transitions)，代表待测的典型离子。
待测的与靶分子有关的典型离子的选择是由本领域技术人员根据标注方法进行的。在再现性和可靠性方面，其选择有利于带来最敏感、最特异以及最有鲁棒性的实验可能性。在所发展的用于选择蛋白质代表性肽(m/z)1的方法中，选择基本上是基于响应强度的。更具体地说，可以参考V.Fusaro et al.[17]。本领域技术人员使用诸如来自AppliedBiosystems或MRMaid的MIDAS和MRM Pilot软件[18]的市场上可以买到的软件可以预测所有可能的转换对。还可以使用F Desiere et al.[19]构建的称为PeptideAtlas的数据库编辑科学界所描述的所有肽的MRM转换。PeptideAtlas数据库可以在因特网上免费使用。对于非蛋白质分子，也可以使用数据库，例如可通过Applied Biosystems公司(美国)的Cliquid软件进入的数据库。
一种选择蛋白质代表性肽的(m/z)2和(m/z)1的替换方法在于使用在其他研究中得到的MS/MS破碎光谱。例如，该研究可以是蛋白质组分析发现和坚定生物标记的各阶段。这一方法是由Thermo Scientific在用户会议中提出的[18]。这使得从通过SIEVE软件(Thermo Scientific)检测而鉴定的肽产生候选转换清单成为可能。J.Mead等[18]详细说明了选择离子的(m/z)2和(m/z)1确定标准如下：
-必须避免有内部裂解位点的肽，即内部有赖氨酸和精氨酸的肽，除非赖氨酸或精氨酸后是脯氨酸；
-必须避免有天冬酰胺或谷氨酰胺的肽，因为会脱氨基；
-必须避免N端有谷氨酰胺或谷氨酸的肽，因为会自发环化；
-必须避免有甲硫氨酸的肽，因为会被氧化；
-必须避免有半胱氨酸的肽，因为会在潜在的变性、还原和封闭硫醇功能的步骤中被不可逆转的修饰；
-有脯氨酸的肽被认为是有利的，因为会产生在MS/MS中非常强烈单峰的集中片段。然而，非常强烈的单峰片段并不能证实复杂混合物中转换的同一性。事实上，只有同时出现几个特征碎片才可以证明所找的前体离子确实被检测到；
-必须避免在临近C端的位置(位置n-1)或相对于C端的第二位(位置n-2)为脯氨酸的肽，因为在这种情况下一般认为第一代肽片段太小而不具备充分特异性；
-优选地选择比前体(m/z)1更大的片段以增强特异性。为了这一目的，必须选择双电荷前体离子和最集中的(m/z)1大于前体的第一代离子片段，即单电荷第一代碎片离子。
对所选的前体离子的破碎是在破碎单元中进行的，例如三连四极子模型、离子陷阱模型或渡越时间模型，这些也能分离离子。破碎的进行照例是在电场中与惰性气体(例如氩气和氮气)碰撞，用强光源进行光激发或者光分解，与电子或放射物碰撞，应用潜在的差异(例如在渡越时间管中)，或者其他的活化模式。电场的性质决定了破碎的强度和性质。因此，在由惰性气体存在时应用的电场，例如在四极子中，决定了提供给离子的碰撞能。本领域技术人员将优化碰撞能以提高待测的转换的敏感性。举例来说，在AB SCIEX5500质谱(Applied Biosystems公司，美国福斯特城)的q2中，可以于5到180e-V之间改变碰撞能。相似地，本领域技术人员将优化碰撞步骤的持续时间和激发能(例如在离子陷阱中)以进行最敏感的实验。举例来说，在AB SCIEX5500质谱(Applied Biosystems公司)的Q3中，持续时间(称为激发时间)在0.010到50ms之间，激发能在0到1(任意单位)之间可以进行改变。
最后，在常规仪器中检测所选典型离子，特别是使用探测器和处理系统的方法。探测器收集离子并产生电信号，其强度取决于收集的离子的数量。得到的信号随后被放大以使其可以被计算机处理。计算机数据处理可以集合地转换质谱探测器得到的信息。
SRM模式甚或MRM模式的原理是特别地选择一个前体离子，将其破碎，然后特别地选择一个碎片离子。对于这些应用，三连四极子或偶联的三连四极子/离子陷阱仪器被普遍使用。
在用于MS2模式的三连四极子(Q1q2Q3)的个案中，以分析或检查靶蛋白为目的，第一个四极子(Q1)可以根据荷质比(m/z)过滤在较早的消化步骤中获得的待测蛋白质特有的蛋白质代表性肽相应的分子离子。只有与要找的蛋白质代表性肽荷质比相同的肽才被散发到第二个四极子(q2)并作为接下来破碎的前体离子，这里的荷质比被称为(m/z)1。q2分析器能够使荷质比为的肽破碎成为第一代碎片离子。破碎一般通过前体肽与诸如氮气或氩气的惰性气体在q2中碰撞获得。第一代碎片离子散发到第三个四极子(Q3)中，其根据特定的称为(m/z)2的荷质比过滤第一代碎片离子。只有荷质比与要找的蛋白质代表性肽的(m/z)2相同的碎片离子被散发到探测器中以检测甚或定量。
当本发明的方法采用的质谱是串联质谱(MS/MS spectrometry)(MS2、MS3、MS4或MS5)时，可以将几个质量分析器连在另一个上。例如，第一个分析器分离离子，碰撞单元使其可以破碎离子，第二个分析器分离碎片离子。诸如离子陷阱和FT-ICR的某些分析器把几个分析器组合成一个，使其可以破碎离子并直接分析碎片。
根据本发明优选的实施方式，本发明的方法包括以下特征中的一个或几个：
-为得到至少一种抗菌剂的潜在抗性的属性而采用的质谱是MS/MS谱，其有利于产生待检测或定量的分子特异的碎片，因而有利于向试验方法提供极大的特异性；
-MS/MS谱是MRM，这有利于利用质谱仪的几十毫秒的分析循环时间，使其能够以高度的敏感性以多路复用方式检测或定量大量不同的分子。
-同时优选地，在适用的情况下，类型属性和毒力因子的确定和对至少一种抗菌剂的抗性的标记的确定是在同一个质谱设备中进行的，这有利于减少分析时间和设备的花费，还会促进结果的处理和产出。除确定抗菌剂的抗性外，还需要鉴别待测样品中的微生物。
鉴别微生物的方法是本领域技术人员公知的，例如Murray P.R.等在临床微生物学手册(Manual of Clinical Microbiology)2007年第九版中所描述的那样，尤其是在第一卷第三部分第十五和十六章关于细菌和酵母、第二卷第六部分第八十二章关于病毒、第二卷第十部分第一百三十五章关于原生动物的内容中。作为常规鉴别方法的例子，上述内容可以包括生物属性的确定，例如，用Vitek 2(bioMérieux)鉴别卡，甚或以基于某些基因的存在和其序列的研究的鉴别标准，使用分子生物学技术。
鉴别可以从鉴别的样品直接进行，或者可以通过本领域技术人员公知的方法用为要找的微生物种量身定做的最适培养基和培养条件培养样品中含有的微生物，如MurrayP.R.等在临床微生物学手册(Manual of Clinical Microbiology)2007年第九版第一卷第三部分第十四章所描述的，特别是在第一卷第四部分第二十一章中关于细菌、第二卷第六部分第八十一张关于病毒、第二卷第八部分第一百一十七章关于酵母和第二卷第十部分第一百三十四章关于原生动物的内容中。
因此，一般来说，在使用生物化学方法鉴别样品中细菌的情况下，首先需要获得纯培养物形式的细菌，例如在接种于琼脂之后。在特定情况下分子生物学(PCR)可以直接用于待分析样品。
除了培养微生物，还可以用活化表面的方法直接从样品中捕获以浓缩微生物。W.-J.Chen等[10]描述了这样一种方法，他们以添加有活化表面的磁珠Fe3O4/TiO2捕获了不同种的细菌。还可以用其他方法进行捕获，例如用凝集素(lectin)，或者抗体，或者万古霉素捕获。捕获可以浓缩微生物，从而减少甚至排除培养步骤。这相当大的节省了时间。
鉴别还可以用质谱进行，根据前面描述的技术，优选用MS、MS/MS甚或用构成本发明一个具体实施方式的连接了MS/MS谱的MS。在这种情况下，样品也可以经受培养的步骤，例如接种到琼脂上。
MS鉴别方法的使用的进步在于可以在几分钟内得以实现，而且要求单分析器的质谱仪，也就是说比串联质谱MS/MS的设备简单。。
通过连接了MS/MS谱的MS鉴别方法的使用也是更进步的。可以检查MS所发现的离子的同一性，这样就提高了分析的特异性。
MRM型MS/MS鉴别方法的使用的好处在于比常规的连接了MS/MS谱的MS方法更敏感更简单。这种方法既不要求高性能软件以处理获得MS谱和MS/MS谱之间的信息，也不要求在设置连接MS和MS/MS谱的机器参数时做改变。
如S.Vaidyanathan等[26]或者R.Everley等[27]描述的那样，用MS鉴别的方法可以和电喷射源一起用于层析分离后的粗样品。这样，不同的m/z范围可以鉴别微生物。S.Vaidyanathan等使用了200到2000Th之间的范围，而R.Everley等使用了620到2450Th之间的范围。质谱还可以去卷积以获取蛋白的质量而不依靠其电荷状态。因此R.Everley等使用大约5,000到50,000Da之间的质量。或者，使用MS的鉴别方法也可以如Claydon等[3]和T.Krishnamurthy与P.Ross[4]所描述的那样采用添加MALDI-TOF。分析结合了质谱的获取和专业软件的翻译。非常简单且能够在几分钟内得以实现。这种鉴别方法在医学分析实验室中越来越广泛传播。
通过样品中存在的其蛋白采用连接MS/MS的MS鉴别细菌被很多团队广泛应用。举例来说，上述包括Manes N.等[29]最近的工作，他们研究肠道沙门氏菌(Salmonellaenterica)的肽组(peptidome)，或者R.Nandakumar等[30]或L.Hernychova等[31]的工作，他们了细菌的以胰蛋白酶进行蛋白消化后的蛋白质组。传统的方法包括ⅰ)获得质谱，ⅱ)依次选择质谱中获得的有强烈信号的每个前体离子，ⅲ)依次破碎每个前体离子并获得其MS/MS谱，ⅳ)通过诸如Mascot(Matrix Science、London、United Kingdom)或SEQUEST(ThermoScientific、Waltham、United States of America)的软件查询诸如SWISS-PROT或NCBI的蛋白质数据库，以鉴别有很大可能性与MS/MS谱发现的肽相匹配的肽。如果鉴别出种特征的蛋白质或多肽，这种方法就可以导致微生物的鉴别。
使用质谱的一个优势在于，在细菌对β-内酰胺抗性机制的标记的实施方式中，其对定量分子尤其有效。有鉴于此，使用了电流强度检测，其与靶分子的量是成比例的。因此，测量的电流强度可以作为定量方法使确定存在的靶分子的量成为可能，这个量的特征在于以国际标准单位mol/m3或kg/m3、或者这些单位的倍数或分数、或者国际标准单位的通常的派生物(其中包括倍数或分数)表达。举一个非限制性的例子，定量方法的特征单位诸如ng/ml或fmol/l。
然而，必须进行标定以使相当于检测的离子所引发的电流强度的测量的峰面积与待测的靶分子的量相关联。为了这个目的，在本发明的架构中，采用质朴中常用的标定。MRM实验通常以添加外参或者优选地添加内参(例如T.Fortin等[13]所描述的)来标定。如果靶分子是使分析感兴趣的分子成为可能的蛋白质代表性肽，定量方法和靶蛋白质代表性肽(继而是感兴趣的蛋白)的量的关联是通过相对于其检测的量已知的标准信号标定测量到的信号而获得的。标定可以用标定曲线进行，例如以连续的注射不同浓度的标准蛋白质代表性肽(外标定)，或者优选的用重肽(heavy peptide)作为内参进行内标定，例如根据如下所述的AQUA、QconCAT或PSAQ法。“重肽”理解为蛋白质代表性肽相应的肽，但是其中的一或几个碳12原子(12C)被碳13(13C)取代，并且/或者一或几个氮14原子(14N)被氮15(15N)取代。
在美国专利申请2004/0229283中也提出将重肽用作内参(AQUA)。原理是以含有较天然的同位素更重的同位素的氨基酸人工合成蛋白质代表性肽。例如，这些氨基酸是通过以碳13(13C)取代碳12原子(12C)，或者以氮15(15N)取代氮14原子(14N)获得的。如此合成的人工肽(AQUA)具有与天然肽严格相同的物理化学性质(除了更大的质量)。通常在质谱分析的上游，例如在引起感兴趣的蛋白的裂解的处理和处理后获得的肽的分馏步骤之间，人工肽以给定浓度添加到样品。这样，AQUA肽与待分析的天然肽在肽分馏期间共纯化。于是，这两种肽被同时注入质谱仪以检测。然后它们在电离源中经历同样的电离得率。天然肽和已知浓度的AQUA肽的峰面积的比较，可以计算天然肽的浓度，从而得到待测蛋白的浓度。AQUA技术的一个变型由J.-M.Pratt等[32]以QconCAT的名称提出。这个变型在专利申请WO 2006/128492中也进行了描述。它由连接各种AQUA肽和产生重重组蛋白形式的人工多肽组成。重组蛋白以含有重同位素的氨基酸合成。用这种方法可以以较低的开销获得标定同时进行的几个蛋白的检测的参照。QconCAT参照一开始即被加入，在引起蛋白的裂解的处理上游，如果存在蛋白质分馏、变性、还原和封闭蛋白硫醇功能的步骤，则在其之前。因此，QconCAT参照与天然蛋白经历同样的引发蛋白裂解的处理周期，这使其可以从引发蛋白裂解的步骤开始顾及得率。事实上，天然蛋白的处理，尤其是消化可能并不完全。在这种情况下，使用AQUA参照会导致低估天然蛋白的量。因此为了完全的检测，可能从引发蛋白裂解的步骤开始顾及得率是重要的。然而，V.Brun等[33]表示QconCAT参照有时不能完全再现处理的得率，尤其是消化天然蛋白，无疑是因为与QconCAT蛋白的三维构象不同。
在此之后，V.Brun等[33]提出使用被称为PSAQ的方法，并在专利申请WO 2008/145763中进行描述。在这个实施方式中，内参是与天然蛋白的序列相同的重组蛋白，但以中氨基酸合成。合成实在体外以重氨基酸进行的。这一参照具有与天然肽严格相同的物理化学性质(除了更大的质量)。参照一开始即被加入，当存在蛋白分馏步骤时，则在其之前。PSAQ展现出与天然蛋白同样的处理得率，尤其是消化处理。如果进行肽分馏步骤，裂解后获得的重肽也与天然肽共纯化。于是，两种肽同时被注入质谱仪以定量分析。然后，它们在电离源中经历相同的电离得率。PSAQ方法中比较天然肽和参照肽可以顾及分析方法中所有步骤地计算待测蛋白的浓度。
所有这些名为AQUA、QconCAT或PSAQ或其他标定技术，用于质谱分析尤其是MRM或MS分析的技术可以用于在本发明构架范围内进行标定。
优选地，根据本发明，检测方法中所用的质谱是MS/MS。更加优选地，质谱是MRM。
本发明的方法可以检测对碳青霉烯的抗性，其特征在于检测至少一种肽作为抗性标记。优选地，所述抗性标记肽从蛋白质NDM、KPC、GES、IMP、IND、SME、VIM或OXA中选择。
具体而言，检测一种由NDM蛋白的表达引发的抗碳青霉烯的机制，其特征在于检测至少一种选自NDM蛋白及其不同序列变体SEQ ID No.1和SEQ ID No.1078到SEQ IDNo.1080的肽。
SEQ ID No.1:
MELPNIMHPVAKLSTALAAALMLSGCMPGEIRPTIGQQMETGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR
SEQ ID No.1078
MELPNIMHPVAKLSTALAAALMLSGCMAGEIRPTIGQQMETGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR
SEQ ID No.1079
MELPNIMHPVAKLSTALAAALMLSGCMPGEIRPTIGQQMETGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLLVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGLVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR
SEQ ID No.1080
MELPNIMHPVAKLSTALAAALMLSGCMPGEIRPTIGQQMETGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR
优选地，所述从序列为SEQ ID No.2到SEQ ID No.9和SEQ ID No.1083的肽中选择的肽定义如下：
优选地，抗性标记是NDM标记，选自序列为SEQ ID No.2、SEQ ID No.3、SEQ IDNo.5、或SEQ ID No.7的肽。
检测一种由KPC蛋白的表达引发的抗碳青霉烯的机制，其特征在于检测至少一种选自KPC蛋白及其不同序列变体SEQ ID No.10到SEQ ID No.19和SEQ ID No.1084到SEQ IDNo.1093的肽。
SEQ ID No.10:
MSLYRRLVLLSCLSWPLAGFSATALTNLVAEPFAKLEQDFGGSIGVYAMDTGSGATVSYRAEERFPLCSSFKGFLAAAVLARSQQQAGLLDTPIRYGKNALVPWSPISEKYLTTGMTVAELSAAAVQYSDNAAANLLLKELGGPAGLTAFMRSIGDTTFRLDRWELELNSAIPGDARDTSSPRAVTESLQKLTLGSALAAPQRQQFVDWLKGNTTGNHRIRAAVPADWAVGDKTGTCGVYGTANDYAVVWPTGRAPIVLAVYTRAPNKDDKHSEAVIAAAARLALEGLGVNGQ
SEQ ID No.11:
MSLYRRLVLLSCLSWPLAGFSATALTNLVAEPFAKLEQDFGGSIGVYAMDTGSGATVSYRAEERFPLCSSFKGFLAAAVLARSQQQAGLLDTPIRYGKNALVPWSPISEKYLTTGMTVAELSAAAVQYSDNAAANLLLKELGGPAGLTAFMRSIGDTTFRLDRWELELNSAIPGDARDTSSPRAVTESLQKLTLGSALAAPQRQQFVDWLKGNTTGNHRIRAAVPADWAVGDKTGTCGVYGTANDYAVVWPTGRAPIVLAVYTRAPNKDDKYSEAVIAAAARLALEGLGVNGQ
SEQ ID No.12:
MSLYRRLVLLSCLSWPLAGFSATALTNLVAEPFAKLEQDFGGSIGVYAMDTGSGATVSYRAEERFPLCSSFKGFLAAAVLARSQQQAGLLDTPIRYGKNALVRWSPISEKYLTTGMTVAELSAAAVQYSDNAAANLLLKELGGPAGLTAFMRSIGDTTFRLDRWELELNSAIPGDARDTSSPRAVTESLQKLTLGSALAAPQRQQFVDWLKGNTTGNHRIRAAVPADWAVGDKTGTCGGYGTANDYAVVWPTGRAPIVLAVYTRAPNKDDKHSEAVIAAAARLALEGLGVNGQ
SEQ ID No.13:
MSLYRRLVLLSCLSWPLAGFSATALTNLVAEPFAKLEQDFGGSIGVYAMDTGSGATVSYRAEERFPLCSSFKGFLAAAVLARSQQQAGLLDTPIRYGKNALVRWSPISEKYLTTGMTVAELSAAAVQYSDNAAANLLLKELGGPAGLTAFMRSIGDTTFRLDRWELELNSAIPGDARDTSSPRAVTESLQKLTLGSALAAPQRQQFVDWLKGNTTGNHRIRAAVPADWAVGDKTGTCGVYGTANDYAVVWPTGRAPIVLAVYTRAPNKDDKHSEAVIAAAARLALEGLGVNGQ
SEQ ID No.14:
MSLYRRLVLLSCLSWPLAGFSATALTNLVAEPFAKLEQDFGGSIGVYAMDTGSGATVSYRAEERFPLCSSFKGFLAAAVLARSQQQAGLLDTPIRYGKNALVPWSPISEKYLTTGMTVAELSAAAVQYSDNAAANLLLKELGGPAGLTAFMRSIGDTTFRLDRWELELNSAIPGDARDTSSPRAVTESLQKLTLGSALAAPQRQQFVDWLKGNTTGNHRIRAAVPADWAVGDKTGTCGGYGTANDYAVVWPTGRAPIVLAVYTRAPNKDDKHSEAVIAAAARLALEGLGVNGQ
SEQ ID No.15:
MSLYRRLVLLSCLSWPLAGFSATALTNLVAEPFAKLEQDFGGSIGVYAIDTGSGATVSYRAEERFPLCSSFKGFLAAAVLARSQQQAGLLDTPIRYGKNALVPWSPISEKYLTTGMTVAELSAAAVQYSDNAAANLLLKELGGPAGLTAFMRSIGDTTFRLDRWELELNSAIPGDARDTSSPRAVTESLQKLTLGSALAAPQRQQFVDWLKGNTTGNHRIRAAVPADWAVGDKTGTCGVYGTANDYAVVWPTGRAPIVLAVYTRAPNKDDKYSEAVIAAAARLALEGLGVNGQ
SEQ ID No.16:
MSLYRRLVLLSCLSWPLAGFSATALTNLVAEPFAKLEQDFGGSIGVYAMDTGSGATVSYRAEERFPLCSSFKGFLAAAVLARSQQQAGLLDTPIRYGKNALVPWSPISEKYLTTGMTVAELSAAAVQYSDNAAANLLLKELGGPAGLTAFMRSIGDTTFRLDRWELELNSAIPGDARDTSSPRAVTESLQKLTLGSALAAPQRQQFVDWLKGNTTGNHRIRAAVPADWAVGDKTGTCGGYGTANDYAVVWPTGRAPIVLAVYTRAPNKDDKYSEAVIAAAARLALEGLGVNGQ
SEQ ID No.17:
MSLYRRLVLLSCLSWPLAGFSATALTNLVAEPFAKLEQDFGGSIGVYAMDTGSGATVSYRAEERFPLCSSFKGFLAAAVLARSQQQAGLLDTPIRYGKNALVPWSPISEKYLTTGMTVAELSAAAVQYSDNAAANLLLKELGGPAGLTAFMRSIGDTTFRLDRWELELNSAIPGDARDTSSPRAVTESLQKLTLGSALAAPQRQQFVDWLKGNTTGNHRIRAAVPADWAVGDKTGTCGAYGTANDYAVVWPTGRAPIVLAVYTRAPNKDDKYSEAVIAAAARLALEGLG
SEQ ID No.18:
MSLYRRLVLLSCLSWPLAGFSATALTNLVAEPFAKLEQDFGGSIGVYAMDTGSGATVSYRAEERFPLCSSFKGFLAAAVLARSQQQAGLLDTPIRYGKNALVRWSPISEKYLTTGMTVAELSAAAVQYSDNAAANLLLKELGGPAGLTAFMRSIGDTTFRLDRWELELNSAIPGDARDTSSPRAVTESLQKLTLGSALAAPQRQQFVDWLKGNTTGNHRIRAAVPADWAVGDKTGTCGVYGTANDYAVVWPTGRAPIVLAVYTRAPNKDDKYSEAVIAAAARLALEGLGVNGQ
SEQ ID No.19:
MSLYRRLVLLSCLSWPLAGFSATALTNLVAEPFAKLEQDFGGSIGVYAMDTGSGATVSYRAEERFPLCSSFKGFLAAAVLARSQQQAGLLDTPIRYGKNALVLWSPISEKYLTTGMTVAELSAAAVQYSDNAAANLLLKELGGPAGLTAFMRSIGDTTFRLDRWELELNSAIPGDARDTSSPRAVTESLQKLTLGSALAAPQRQQFVDWLKGNTTGNHRIRAAVPADWAVGDKTGTCGVYGTANDYAVVWPTGRAPIVLAVYTRAPNKDDKHSEAVIAAAARLALEGLGVNGQ
SEQ ID No.1084
MSLYRRLVLLSCLSWPLAGFSATALTNLVAEPFAKLEQDFGGSIGVYAMDTGSGATVSYRAEERFPLCSSFKGFLAAAVLARSQQQAGLLDTPIRYGKNALVPWSPISEKYLTTGMTVAELSAAAVQYSDNAAANLLLKELGGPAGLTAFMRSIGDTTFRLDRWELELNSAIPGDARDTSSPRAVTESLQKLTLGSALAAPQRQQFVDWLKGNTTGNHRIRAAVPADWAVGDKTGTCGGYGTANDYAVVWPTGRAPIVLAVYTRAPNKDDKHSEAVIAAAARLALEGLGVNGQ
SEQ ID No.1085
MSLYRRLVLLSCLSWPLAGFSATALTNLVAEPFAKLEQDFGGSIGVYAMDTGSGATVSYRAEERFPLCSSFKGFLAAAVLARSQQQAGLLDTPIRYGKNALVPWSPISEKYLTTGMTVAELSAAAVQYSDNAAANLLLKELGGPAGLTAFMRSIGDTTFRLDRWELELNSAIPGDARDTSSPRAVTESLQKLTLGSALAAPQRQQFVDWLKGNTTGNHRIRAAVPADWAVGDKTGTCGGYGTANDYAVVWPTGRAPIVLAVYTRAPNKDDKYSEAVIAAAARLALEGLGVNGQ
SEQ ID No.1086
MSLYRRLVLLSCLSWPLAGFSATALTNLVAEPFAKLEQDFGGSIGVYAMDTGSGATVSYRAEERFPLCSSFKGFLAAAVLARSQQQAGLLDTPIRYGKNALVPWSPISEKYLTTGMTVAELSAAAVQYSDNAAANLLLKELGGPAGLTAFMRSIGDTTFRLDRWELELNSAIPGDARDTSSPRAVTESLQKLTLGSALAAPQRQQFVDWLKGNTTGNHRIRAAVPADWAVGDKTGTCGVYGTANDYAVVWPTGRAPIVLAVYTRAPNKDDKHSEAVIAAAARLALEGLGVNGQ
SEQ ID No.1087
MSLYRRLVLLSCLSWPLAGFSATALTNLVAEPFAKLEQDFGGSIGVYAMDTGSGATVSYRAEERFPLCSSFKGFLAAAVLARSQQQAGLLDTPIRYGKNALVPWSPISEKYLTTGMTVAELSAAAVQYSDNAAANLLLKELGGPAGLTAFMRSIGDTTFRLDRWELELNSAIPGDARDTSSPRAVTESLQKLTLGSALAAPQRQQFVDWLKGNTTGNHRIRAAVPADWAVGDKTGTCGVYGTANDYAVVWPTGRAPIVLAVYTRAPNKDDKYSEAVIAAAARLALEGLGVNGQ
SEQ ID No.1088
MSLYRRLVLLSCLSWPLAGFSATALTNLVAEPFAKLEQDFGGSIGVYAMDTGSGATVSYRAEERFPLCSSFKGFLAAAVLARSQQQAGLLDTPIRYGKNALVPWSPISEKYLTTGMTVAELSAAAVQYSDNAAANLLLKELGGPAGLTAFMRSIGDTTFRLDRWELELNSAIPSDARDTSSPRAVTESLQKLTLGSALAAPQRQQFVDWLKGNTTGNHRIRAAVPADWAVGDKTGTCGVYGTANDYAVVWPTGRAPIVLAVYTRAPNKDDKHSEAVIAAAARLALEGLGVNGQ
SEQ ID No.1089
MSLYRRLVLLSCLSWPLAGFSATALTNLVAEPFAKLEQDFGGSIGVYAMDTGSGATVSYRAEERFPLCSSFKGFLAAAVLARSQQQAGLLDTPIRYGKNALVPWSPISEKYLTTGMTVAELSAAAVQYSDNAAANLLLKELGGPAGLTAFMRSIGDTTFRLDRWELEMNSAIPGDARDTSSPRAVTESLQKLTLGSALAAPQRQQFVDWLKGNTTGNHRIRAAVPADWAVGDKTGTCGVYGTANDYAVVWPTGRAPIVLAVYTRAPNKDDKHSEAVIAAAARLALEGLGVNGQ
SEQ ID No.1090
MSLYRRLVLLSCLSWPLAGFSATALTNLVAEPFAKLEQDFGGSIGVYAMDTGSGATVSYRAEERFPLCSSFKGFLAAAVLARSQQQAGLLDTPIRYGKNALVRWSPISEKYLTTGMTVAELSAAAVQYSDNAAANLLLKELGGPAGLTAFMRSIGDTTFRLDRWELELNSAIPGDARDTSSPRAVTESLQKLTLGSALAAPQRQQFVDWLKGNTTGNHRIRAAVPADWAVGDKTGTCGVYGTANDYAVVWPTGRAPIVLAVYTRAPNKDDKHSEAVIAAAARLALEGLGVNGQ
SEQ ID No.1091
MSLYRRLVLLSCLSWPLAGFSATALTNLVAEPFAKLEQDFGGSIGVYAMDTGSGATVSYRAEERFPLCSSFKGFLAAAVLARSQQQAGLLDTPIRYGKNALVRWSPISEKYLTTGMTVAELSAAAVQYSDNAAANLLLKELGGPAGLTAFMRSIGDTTFRLDRWELELNSAIPGDARDTSSPRAVTESLQKLTLGSALAAPQRQQFVDWLKGNTTGNHRIRAAVPADWAVGDKTGTCGVYGTANDYAVVWPTGRAPIVLAVYTRAPNKDDKYSEAVIAAAARLALEGLGVNGQ
SEQ ID No.1092
RLVLLSCLSWPLAGFSATALTNLVAEPFAKLEQDFGGSIGVYAMDTGSGATVSYRAEERFPLCSSFKGFLAAAVLARSQQQAGLLDTPIRYGKNALVPWSPISEKYLTTGMTVAELSAAAVQYSDNAAANLLLKELGGPAGLTAFMRSIGDTTFRLDRWELELNSAIPGDARDTSSPRAVTESLQKLTLGSALAAPQRQQFVDWLKGNTTGNHRIRAAVPADWAVGDKTGTCGAYGTANDYAVVWPTGRAPIVLAVYTRAPNKDDKYSEAVIAAAARLALEGLG
SEQ ID No.1093
SLYRRLVLLSCLSWPLAGFSATALTNLVAEPFAKLEQDFGGSIGVYAMDTGSGATVSYRAEERFPLCSSFKGFLAAAVLARSQQQAGLLDTPIRYGKNALVRWSPISEKYLTTGMTVAELSAAAVQYSDNAAANLLLKELGGPAGLTAFMRSIGDTTFRLDRWELELNSAIPGDARDTSSPRAVTESLQKLTLGSALAAPQRQQFVDWLKGNTTGNHRIRAAVPADWAVGDKTGTCGGYGTANDYAVVWPTGRAPIVLAVYTRAPNKDDKHSEAVIAAAARLALEGLGVNGQ
优选地，所述肽选自如下定义的序列为SEQ ID No.20到SEQ ID No.33和SEQ IDNo.1094到SEQ ID No.1097的肽：
优选地，抗性标记是KPC标记，选自序列为SEQ ID No.20、SEQ ID No.21、SEQ IDNo.23、SEQ ID No.25、SEQ ID No.28、SEQ ID No.29、SEQ ID No.31、或SEQ ID No.32的肽。
检测一种由GES蛋白的表达引发的抗碳青霉烯和/或头孢菌素的机制，其特征在于检测至少一种选自GES蛋白及其不同序列变体SEQ ID No.34到SEQ ID No.50的肽。
SEQ ID No.34
MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQRFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVEWSPATERFLASGHMTVLEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMGDNTPGDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVGEKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILSTDK
SEQ ID No.35
MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQRFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVKWSPATERFLASGHMTVLEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMGDNTPGDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVGEKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILSTDK
SEQ ID No.36
MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQRFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVEWSPATERFLASGHMTVLEAAQLAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMGDNTPGDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVGEKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILSTDK
SEQ ID No.37
MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQRFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVEWSPATERFLASGHMTVLEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMNDNTPGDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVGEKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILSTDK
SEQ ID No.38
MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQRFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVEWSPATERFLASGHMTVLEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMSDNTPGDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVGEKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILSTDK
SEQ ID No.39
MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQRFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVKWSPATERFLASGHMTVLEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMSDNTPGDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVGEKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILSTDK
SEQ ID No.40
MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQRFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVEWSPATERFLASGHMTVLEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMGDNTPGDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVGEKTGTCANGSRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILSTDK
SEQ ID No.41
MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQRFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVEWSPATERFLASGHMTVLEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMGDNTPGDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVGEKTGTCANGARNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILSTDK
SEQ ID No.42
MRFIHALLLAGTAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRTAQRFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVEWSPATERFLASGHMTVLEAAQAAVQLCDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMGDNTPGDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVGEKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILSTDK
SEQ ID No.43
MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQRFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVKWSPATERFLASGHMTVLEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMNDNTPGDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVGEKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILSTDK
SEQ ID No.44
MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQRFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVEWSPATERFLASGHMTVLEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKESEMSDNTPGDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVGEKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILSTDK
SEQ ID No.45
MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQRFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVEWSPATERFLASGHMTVLEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMSDNTPGDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVGEKTGTCANGARNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILSTDK
SEQ ID No.46
MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAEIGVAIVDPQGEIVAGHRMAQRFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVEWSPATERFLASGHMTVLEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMSDNTPGDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVGEKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILSTDK
SEQ ID No.47
MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQRFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVKWSPATERFLASGHMTVLEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMGDNTPGDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVGEKTGTCANGARNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILSTDK
SEQ ID No.48
MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRTAQRFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVKWSPATERFLASGHMTVLEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMGDNTPGDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVGEKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILSTDK
SEQ ID No.49
MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRTAQRFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVKWSPATERFLASGHMTVLEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMSDNTPGDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVGEKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILSTDK
SEQ ID No.50
MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQRFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVEWSPATERFLASGHMTVLEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMGDNTPGDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVGEKTGACANGARNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILSTDK
优选地，所述肽选自定义如下的序列为SEQ ID No.51到SEQ ID No.79的肽：
在临床意义栏，ESBL和carba条目对应GESβ-内酰胺酶活性，而相应的肽可以检测该酶活性。因此，检测到carba肽将证明能够水解碳青霉烯的碳青霉烯酶β-内酰胺酶的存在。
如果没有检测到被称为carba的肽，检测到被称为ESBL的肽将证明能够超广谱(ESBL)的水解青霉素、诸如头孢菌素Ⅱ和头孢噻吩的第一代头孢菌素和至少一种来自诸如头孢噻肟、头孢他啶的氧亚氨基β-内酰胺或诸如氨曲南的单环β-内酰胺类的抗生素的β-内酰胺酶的存在。
检测一种由GES蛋白的表达引发的抗碳青霉烯的机制，其特征在于检测至少一种选自序列为SEQ ID No.51、59、60、61、64、70、73、74、76、79的抗性标记carba肽。
检测一种由IMP蛋白的表达引发的抗碳青霉烯的机制，其特征在于检测至少一种选自IMP蛋白及其不同序列变体SEQ ID No.80到SEQ ID No.105的肽。
SEQ ID No.80:
MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN
SEQ ID No.81:
MKKLSVFFMFLFCSIAASGEALPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNTDAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSQSIPTYASELTNELLKKDGKVQAKNSFSGASYWLVKKKIEIFYPGPGHTPDNVVVWLPEHRVLFGGCFVKPYGLGNLGDANLEAWPKSAKLLVSKYGKAKLVVPSHSEVGDASLLKRTLEQAVKGLNESKKLSKPSN
SEQ ID No.82:
MSKLSVFFIFLFCSIATAAEPLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVDAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSQSIPTYASELTNELLKKDGKVQAKNSFGGVNYWLVKNKIEVFYPGPGHTPDNLVVWLPERKILFGGCFIKPYGLGNLGDANLEAWPKSAKLLISKYGKAKLVVPSHSEAGDASLLKLTLEQAVKGLNESKKPSKLSN
SEQ ID No.83:
MKKLFVLCVCFLCSITAAGAALPDLKIEKLEEGVYVHTSFEEVNGWGVVSKHGLVVLVNTDAYLIDTPFTATDTEKLVNWFVERGYKIKGTISSHFHSDSTGGIEWLNSQSIPTYASELTNELLKKDGKVQAKNSFSGVSYWLVKNKIEVFYPGPGHTQDNVVVWLPEKKILFGGCFVKPDGLGNLGDANLEAWPKSAKILMSKYGKAKLVVSSHSEIGDASLLKRTWEQAVKGLNESKKPSQPSN
SEQ ID No.84:
MSKLFVFFMFLFCSITAAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNTEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSQSIPTYASELTNELLKKDGKVQAKNSFSGASYWLVKKKIEVFYPGPGHTPDNVVVWLPENRVLFGGCFVKPYGLGNLGDANVEAWPKSAKLLMSKYGKAKLVVPSHSEVGDASLLKRTLEQAVKGLNESKKPSKPSN
SEQ ID No.85:
MSKLFVFFMFLFCSITAAGESLPDLKIEKLDEGVYVHTSFEEVNGWGVIPKHGLVVLVNTDAYLIDTPFTAKDTENLVNWFVERGYRIKGSISSHFHSDSTGGIEWLNSQSIPTYASELTNELLKKDGKVQAKYSFSGVSYWLVKKKIEVFYPGPGHAPDNVVVWLPENRVLFGGCFVKPYGLGNLGDANLEAWPKSAKLLMSKYSKAKLVVPSHSDIGDSSLLKLTWEQTVKGFNESKKSTTAH
SEQ ID No.86:
MKKLFVLCVFFFCNIAVAEESLPDLKIEKLEEGVYVHTSFEEVKGWSVVTKHGLVVLVKNDAYLIDTPITAKDTEKLVNWFVERGYKIKGSISTHFHGDSTAGIEWLNSQSIPTYASELTNELLKKDNKVQAKHSFNGVSYSLIKNKIEVFYPGPGHTQDNVVVWLPEKKILFGGCFVKPDGLGYLGDANLEAWPKSAKILMSKYGKAKLVVSSHSDIGDVSLLKRTWEQAVKGLNESKKSSQPSD
SEQ ID No.87:
MNKLSVFFMFMFCSITAAGESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNTEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSQSIPTYASELTNELLKKDGKVQAKNSFSGGSYWLVNNKIEVFYPGPGHTPDNVVVWLPENRVLFGGCFVKPYGLGNLGDANLEAWPKSAKILMSKYGKAKLVVSSHSETGNASLLKLTWEQAVKGLKESKKPSLPSN
SEQ ID No.88:
MKKLFVLCVFFLCNIAAADDSLPDLKIEKLEKGVYVHTSFEEVKGWGVVTKHGLVVLVKNDAYLIDTPITAKDTEKLVNWFIEHGYRIKGSISTHFHGDSTAGIEWLNSQSISTYASELTNELLKKDNKVQATNSFSGVSYSLIKNKIEVFYPGPGHTQDNVVVWLPEKKILFGGCFVKPDGLGNLGDANLEAWPKSAKILMSKYGKAKLVVSSHSEIGNASLLQRTWEQAVKGLNESKKPLQPSS
SEQ ID No.89:
MKKLFVLCVFLFCSITAAGESLPDLKIEKLEEGVYVHTSFEEVNGWGVVSKHGLVILVNTDAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSQSIPTYASELTNDLLKQNGKVQAKNSFSGVSYWLVKNKIEVFYPGPGHTQDNVVVWLPEKKILFGGCFVKPYGLGNLDDANVVAWPHSAEILMSRYGNAKLVVPSHSDIGDASLLKLTWEQAVKGLKESKKPSEPSN
SEQ ID No.90:
MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFKEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN
SEQ ID No.91:
MKKLFVLCVCFLCSITAAGAALPDLKIEKLEEGVYVHTSFEEVNGWGVVSKHGLVVLVNTDAYLIDTPFTATDTEKLVNWFVERGYKIKGTISSHFHSDSTGGIEWLNSQSIPTYASELTNELLKKDGKVQAKNSFSGVSYWLVKNKIEVFYPGPGHTQDNVVVWLPEKKILFGGCFVKPDGLGNLGDANLEAWPKSAKILMSKYVKAKLVVSSHSEIGDASLLKRTWEQAVKGLNESKKPSQPSN
SEQ ID No.92:
MKKLFVLCVCFLCSITAAGAALPDLKIEKLEEGVYVHTSFEEVNGWGVVSKHGLVVLVNTDAYLIDTPFTATDTEKLVNWFVERGYKIKGTISSHFHSDSTGGIEWLNSQSIPTYASELTNELLKKDGKVQAKNSFSGVSYWLVKNKIEVFYPGPGHTQDNVVVWLPEKKILFGGCFVKPDGLGNLGDANLEAWPKSAKILMSKYGKAKLVVSSHSEIGDASLLKRTWEQAVKGLNESRKPSQPSN
SEQ ID No.93:
MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLSDANIEAWPKSAKLLKSKYGKAKLVVPGHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN
SEQ ID No.94:
MSKLSVFFIFLFCSIATAAEPLPDLKIEKLDEGVYVHTSFEEVNGWGVFPKHGLVVLVDAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSQSIPTYASELTNELLKKDGKVQAKNSFGGVNYWLVKNKIEVFYPGPGHTPDNLVVWLPERKILFGGCFIKPYGLGNLGDANLEAWPKSAKLLISKYGKAKLVVPSHSEAGDASLLKLTLEQAVKGLNESKKPSKLSN
SEQ ID No.95:
MKKLFVLCVFVFCSITVAGETLPNLRVEKLEEGVYVHTSYEEVKGWGVVTKHGLVVLIGADAYLIDTPFTAKDTEKLVNWFVERGYKIKGTVSSHFHSDSTGGIEWLNSQSIPTYASELTNELLKKDGKVQAKNSFDGVSYWLAKDKIEVFYPGPGHTQDNVVVWLPEKEILFGGCFVKPHGLGNLGDANLEAWPESAKILMEKYGKAKLVVSGHSETGDATHLKRTWEQAVKGLKESKKTLQPSN
SEQ ID No.96:
MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIGWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPGHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN
SEQ ID No.97:
MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPGHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN
SEQ ID No.98:
MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVFPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN
SEQ ID No.99:
MKKLFVLCIFLFCSITAAGASLPDLKIEKLEEGVYVHTSFEEVNGWGVVSKHGLVVLVNTDAYLIDTPFTAKDTEKLVNWFVERGYKIKGSISSHFHSDSTGGIEWLNSQSIPTYASVLTNELLKKDGKVQAKNSFSGVSYWLVKNKIEVFYPGPGHTQDNVVVWLPKNKILFGGCFVKPYGLGNLDDANVEAWPHSAEKLISKYGNAKLVVPSHSDIGDASLLKLTWEQAVKGLNESKKSNTVH
SEQ ID No.100:
MKKLFVLCVCFLCSITAAGAALPDLKIEKLEEGVYVHTSFEEVNGWGVFSKHGLVVLVNTDAYLIDTPFTATDTEKLVNWFVERGYKIKGTISSHFHSDSTGGIEWLNSQSIPTYASELTNELLKKDGKVQAKNSFSGVSYWLVKNKIEVFYPGPGHTQDNVVVWLPEKKILFGGCFVKPDGLGNLGDANLEAWPKSAKILMSKYVKAKLVVSSHSEIGDASLLKRTWEQAVKGLNESKKPSQPSN
SEQ ID No.101:
MKKLFVLCIFLFCSITAAGASLPDLKIEKLEEGVYVHTSFEEVNGWGVASKHGLVVLVNTDAYLIDTPFTAKDTEKLVNWFVERGYKIKGSISSHFHSDSTGGIEWLNSQSIPTYASVLTNELLKKDGKVQAKNSFSGVSYWLVKNKIEVFYPGPGHTQDNVVVWLPKNKILFGGCFVKPYGLGNLDDANVEAWPHSAEKLISKYGNAKLVVPSHSDIGDASLLKLTWEQAVKGLNESKKSNTVH
SEQ ID No.102:
MKKLFVLCVCFLCSITAAGARLPDLKIEKLEEGVYVHTSFEEVNGWGVVSKHGLVVLVNTDAYLIDTPFTATDTEKLVNWFVERGYKIKGTISSHFHSDSTGGIEWLNSQSIPTYASELTNELLKKDGKVQAKNSFSGVSYWLVKNKIEVFYPGPGHTQDNVVVWLPEKKILFGGCFVKPDGLGNLGDANLEAWPKSAKILMSKYVKAKLVVSSHSEIGDASLLKRTWEQAVKGLNESKKPSQPSN
SEQ ID No.103:
MKKLFVLCIFLFLSITASGEVLPDLKIEKLEEGVYLHTSFEEVSGWGVVTKHGLVVLVNNDAYLIDTPFTNKDTEKLVAWFVGRGFTIKGSVSSHFHSDSTGGIEWLNSQSIPTYASELTNELLKKNGKVQATNSFSGVSYWLVKNKIEIFYPGPGHTQDNVVVWLPENKILFGGCFVKPDGLGNLDDANLKAWPKSAKILMSKYGKAKLVVSGHSEIGNASLLKLTWEQAVKGLKESKKPLLPSN
SEQ ID No.104:
MKKLFVLCVCFFCSITAAGAALPDLKIEKLEEGVFVHTSFEEVNGWGVVTKHGLVVLVNTDAYLIDTPFTATDTEKLVNWFVERGYEIKGTISSHFHSDSTGGIEWLNSQSIPTYASELTNELLKKSGKVQAKYSFSEVSYWLVKNKIEVFYPGPGHTQDNLVVWLPESKILFGGCFIKPHGLGNLGDANLEAWPKSAKILMSKYGKAKLVVSSHSEKGDASLMKRTWEQALKGLKESKKTSSPSN
SEQ ID No.105:
MKKLFVLCIFLFCSITAAGESLPDLKIEKLEDGVYVHTSFEEVNGWGVVTKHGLVFLVNTDAYLIDTPFAAKDTEKLVNWFVERGYKIKGSISSHFHSDSSGGIEWLNSQSIPTYASELTNELLKKNGKVQAKNSFSGVSYWLLKNKIEIFYPGPGHTQDNVVVWLPEKKILFGGCFVKPYGLGNLDDANVEAWPHSAEILMSRYGNAKLVVPSHSDVGDASLLKLTWEQAVKGLKESKKPSQPSN
优选地，所述肽选自如下定义的序列为SEQ ID No.106、SEQ ID No.108到SEQ IDNo.130、SEQ ID No.133到SEQ ID No.173、SEQ ID No.175到SEQ ID No.180的肽：
检测一种由IND蛋白的表达引发的抗碳青霉烯的机制，其特征在于检测至少一种选自IND蛋白及其不同序列变体SEQ ID No.181到SEQ ID No.187的肽。
SEQ ID No.181:
MKKSIRFFIVSILLSPFASAQVKDFVIEPPIKNNLHIYKTFGVFGGKEYSANSMYLVTKKGVVLFDVPWEKIQYQSLMDTIKKRHNLPVVAVFATHSHDDRAGDLSFFNNKGIKTYATAKTNEFLKKDGKATSTEIIKTGKPYRIGGEEFVVDFLGEGHTADNVVVWFPKYNVLDGGCLVKSNSATDLGYIKEANVEQWPKTINKLKAKYSKATLIIPGHDEWKGGGHVEHTLELLNKK
SEQ ID No.182:
MKKSIQLLMMSMFLSPLINAQVKDFVIEPPVKPNLYLYKSFGVFGGKEYSANAVYLTTKKGVVLFDVPWQKEQYQTLMDTIQKRHHLPVIAVFATHSHDDRAGDLSFYNQKGIKTYATAKTNELLKKDGKATSTEIIKTGKPYKIGGEEFMVDFLGEGHTVDNVVVWFPKYKVLDGGCLVKSRTATDLGYTGEANVKQWPETMRKLKTKYAQATLVIPGHDEWKGGGHVQHTLDLLDKNKKPE
SEQ ID No.183:
MKKSIQLLMMSMFLSPLINAQVKDFVIEPPVKPNLYLYKSFGVFGGKEYSANAVYLTTKKGVVLFDVPWQKEQYQTLMDTIQKRHHLPVIAVFATHSHDDRAGDLSFYNQKGIKTYATAKTNELLKKDGKATSTEIIKTGKPYKIGGEEFMVDFLGEGHTVDNVVVWFPKYKVLDGGCLVKSRTATDLGYTGEANVKQWPETMRKLKTKYAQATLVIPGHEEWKGGGHVQHTLDLLDKNKKPE
SEQ ID No.184:
MKKRIQFFMVSMMLSSLFSAQVKDFVIEPPIKKNLHIYKTFGVFGGKEYSANSVYLVTQKGVVLFDVPWEKVQYQSLMDTIQKRHNLPVIAVFATHSHDDRAGDLSFFNNKGIKTYATSKTNEFLKKDGKATSTEIIKTGKPYRIGGEEFVVDFLGEGHTADNVVVWFPKYNVLDGGCLVKSKAATDLGYIKEANVEQWPKTINKLKSKYSKASLVIPGHDEWKGGGHVKHTLELLNKK
SEQ ID No.185:
MRKNVRIFTVLSLFLINFFNAQARDFVIEQPFGKQLYLYKTFGVFDGKEYSTNALYLVTKKGVVLFDVPWQKTQYQSLMDTIKKRHNLPVIAVFATHSHSDRAGDLSFYNKKGIPTYATAKTNELLKKEGKATSSKLTKIGKKYKIGGEEFTVDFLGEGHTADNVVVWFPKYNVLDGGCLVKSSAAVDLGYTGEANVEQWPATMKKLQAKYPSTAKVIPGHDEWKGNDHVKHTLELLDQQKQ
SEQ ID No.186:
MKKRIQFFMVSMMLAPMFNAQVKDFVIEPPIKNNLHIYKTFGVFGGKEYSANSVYLVTKKGVVLFDVPWEKAQYQSLMDTIKKRHNLPVIAVFATHSHDDRAGDLSFFNNKGIKTYATSKTNEFLKKDGKATSTEIIKTGKPYRIGGEEFTVDFLGEGHTADNVVVWFPKYNVLDGGCLVKSNSATDLGYIKEANVEQWPITIDKLKAKYSKATLIIPGHDDWKGGGHVEHTLELLNKK
SEQ ID No.187:
MKRRIQFFMVSMMLTPLFSAQVKDFVIEPPIKKNLYIYKTFGVFGGKEYSANSVYLVTKTGVVLFDVPWEKAQYQSLMDTIKKRHNLPVVAVFATHSHDDRAGDLSFFNNKGIKTYATPKTNQFLKRDGKATSTELIKPGKPYRFGGEEFVVDFLGEGHTADNVVVWFPKYKVLDGGCLVKSNSATDLGYIKEANLEQWPKTMHKLKTKYSEAVLIIPGHDEWKGGGHVEHTLELLDKK
优选地，所述肽选自如下定义的序列为SEQ ID No.188到SEQ ID No.197、SEQ IDNo.200、SEQ ID No.201、SEQ ID No.203到SEQ ID No.262的肽：
检测一种由SME蛋白的表达引发的抗碳青霉烯的机制，其特征在于检测至少一种选自SME蛋白及其不同序列变体SEQ ID No.263到SEQ ID No.265的肽。
SEQ ID No 263:
MSNKVNFKTASFLFSVCLALSAFNAHANKSDAAAKQIKKLEEDFDGRIGVFAIDTGSGNTFGYRSDERFPLCSSFKGFLAAAVLERVQQKKLDINQKVKYESRDLEYHSPITTKYKGSGMTLGDMASAALQYSDNGATNIIMERFLGGPEGMTKFMRSIGDNEFRLDRWELELNTAIPGDKRDTSTPKAVANSLNKLALGNVLNAKEKAIYQNWLKGNTTGDARIRASVPADWVVGDKTGSCGAYGTANDYAVIWPKNRAPLIVSIYTTRKSKDDKHSDKTIAEASRIAIQAID
SEQ ID No.264:
MSNKVNFKTASFLFSVCLALSAFNAHANKSDAAAKQIKKLEEDFDGRIGVFAIDTGSGNTFGYRSDERFPLCSSFKGFLAAAVLERVQQKKLDINQKVKYESRDLEYYSPITTKYKGSGMTLGDMASAALQYSDNGATNIIMERFLGGPEGMTKFMRSIGDNEFRLDRWELELNTAIPGDKRDTSTPKAVANSLNKLALGNVLNAKVKAIYQNWLKGNTTGDARIRASVPADWVVGDKTGSCGAYGTANDYAVIWPKNRAPLIVSIYTTRKSKDDKHSDKTIAEASRIAIQAID
SEQ ID No.265:
MSNKVNFKTASFLFSVCLALSAFNAHANKSDAAAKQIKKLEEDFDGRIGVFAIDTGSGNTFGYRSDERFPLCSSFKGFLAAAVLERVQQKKLDINQKVKYESRDLEYHSPITTKYKGSGMTLGDMASAALQYSDNGATNIIMERFLGGPEGMTKFMRSIGDNEFRLDRWELELNTAIPGDKRDTSTPKAVANSLNKLALGNVLNAKVKAIYQNWLKGNTTGDARIRASVPADWVVGDKTGSCGAIGTANDYAVIWPKNRAPLIVSIYTTRKSKDDKHSDKTIAEASRIAIQAID
优选地，所述肽选自如下定义的序列为SEQ ID No.266到SEQ ID No.287的肽：
检测一种由VIM蛋白的表达引发的抗碳青霉烯的机制，其特征在于检测至少一种选自VIM蛋白及其不同序列变体SEQ ID No.288到SEQ ID No.313的肽。
SEQ ID No.288:
MFKLLSKLLVYLTASIMAIASPLAFSVDSSGEYPTVSEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEVEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSASVLYGGCAIYELSRTSAGNVADADLAEWPTSIERIQQHYPEAQFVIPGHGLPGGLDLLKHTTNVVKAHTNRSVVE
SEQ ID No.289:
MFKLLSKLLVYLTASIMAIASPLAFSVDSSGEYPTVSEIPVGEVRLYQIADGVWSHIATKSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEVEGSEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSASVLYGGCAIYELSRTSAGNVADADLAEWPTSIERIQQHYPEAQFVIPGHGLPGGLDLLKHTTNVVKAHTNRSVVE
SEQ ID No.290:
MLKVISSLLVYMTASVMAVASPLAHSGEPSGEYPTVNEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEAEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSANVLYGGCAVHELSRTSAGNVADADLAEWPTSVERIQKHYPEAEVVIPGHGLPGGLDLLQHTANVVKAHKNRSVAE
SEQ ID No.291:
MLKVISSLLVYMTASVMAVASPLAHSGEPSGEYPTVNEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRKAGVATYASPSTRRLAEAEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSANVLYGGCAVLALSRTSAGNVADADLAEWPTSVERIQKHYPEAEVVIPGHGLPGGLDLLQHTANVVTAHKNRSVAE
SEQ ID No.292:
MFKLLSKLLVYLTASIMAIASPLAFSVDSSGEYPTVSEIPVGEVRLYQIADGVWSHIATRSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEVEGSEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSASVLYGGCAIYELSRTSAGNVADADLAEWPTSIERIQQHYPEAQFVIPGHGLPGGLDLLKHTTNVVKAHTNRSVVE
SEQ ID No.293:
MFKLLSKLLVYLTASIMAIASPLAFSVDSSGEYPTVSEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSARRLAEVEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSASVLYGGCAIYELSRTSAGNVADADLAEWPTSIERIQQHYPEAQFVIPGHGLPGGLDLLKHTTNVVKAHTNRSVVE
SEQ ID No.294:
MFKLLSKLLVYLTASIMAIASPLAFSVDSSGEYPTVSEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSIRRLAEVEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSASVLYGGCAIYELSRTSAGNVADADLAEWPTSIERIQQHYPEAQFVIPGHGLPGGLDLLKHTTNVVKAHTNRSVVE
SEQ ID No.295:
MFKLLSKLLVYLTASIMAIASPLAFSVDSSGEYPTVSEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEVEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSASVLYGGCAIYELSRTSAGNVADADLAEWPTSIERIQQHYPEAQYVIPGHGLPGGLDLLKHTTNVVKAHTNRSVVE
SEQ ID No.296:
MFKLLSKLLVYLTASIMAIASPLAFSVDSSGEYPTVSEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEVEGSEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSASVLYGGCAIYELSRTSAGNVADADLAEWPTSIERIQQHYPEAQFVIPGHGLPGGLDLLKHTTNVVKAHTNRSVVE
SEQ ID No.297:
MLKVISSLLVYMTASVMAVASPLAHSGEPSSEYPTVNEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEAEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSANVLYGGCAVHELSRTSAGNVADADLAEWPTSVERIQKHYPEAEVVIPGHGLPGGLDLLQHTANVVKAHKNRSVAE
SEQ ID No.298:
MLKVISSLLVYMTASVMAVASPLAHSGEPSGEYPTVNEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEAEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSANVLYGGCAVHELSSTSAGNVADADLAEWPTSIERIQQHYPEAQFVIPGHGLPGGLDLLKHTTNVVKAHTNRSVVE
SEQ ID No.299:
MLKVISSLLFYMTASLMAVASPLAHSGESRGEYPTVSEIPVGEVRLYQIDDGVWSHIATHTFDGVVYPSNGLIVRDGDELLLIDTAWGTKNTVALLAEIEKQIGLPVTRSVSTHFHDDRVGGVDALRAAGVATYASPSTRRLAEAEGNEVPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSANVLYGGCAVLELSRTSAGNVADADLAEWPGSVERIQQHYPEAEVVIPGHGLPGGLDLLQHTANVVKAHTNRSVAE
SEQ ID No.300:
MFKLLSKLLVYLTASMMAIASPLAFSVDSSGEYPTVSEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEVEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSASVLYGGCAIYELSRTSAGNVADADLAEWPTSIERIQQHYPEAQFVIPGHGLPGGLDLLKHTTNVVKAHTNRSVVE
SEQ ID No.301:
MFKLLSKLLVYLTASIMAIASPLAFSVDSSGEYPTVSEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEVEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSASVLFGGCAIYELSRTSAGNVADADLAEWPTSIERIQQHYPEAQFVIPGHGLPGGLDLLKHTTNVVKAHTNRSVVE
SEQ ID No.302:
MFKLLSKLLVYLTASIMAIASPLAFSVDSSGEYPTVSEIPVGEVRLYQIADGVWLHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEVEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSASVLYGGCAIYELSRTSAGNVADADLAEWPTSIERIQQHYPEAQFVIPGHGLPGGLDLLKHTTNVVKAHTNRSVVE
SEQ ID No.303:
MFKLLSKLLVYLTASIMAIASPLAFSVDSSGEYPTVSEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEVEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSASVLYGGCAIYELSSTSAGNVADADLAEWPTSIERIQQHYPEAQFVIPGHGLPGGLDLLKHTTNVVKAHTNRSVVE
SEQ ID No.304:
MLKVISSLLVYMTASVMAVASPLAHSGEPSGEYPTVNEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEAEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSAKVLYGGCAVHELSRTSAGNVADADLAEWPTSVERIQKHYPEAEVVIPGHGLPGGLDLLQHTANVVKAHKNRSVAE
SEQ ID No.305:
MFKLLSKLLVYLTASIMAIASPLAFSVDSSGEYPTVSEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEVEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSASVLYGGCAIYELSLTSAGNVADADLAEWPTSIERIQQHYPEAQFVIPGHGLPGGLDLLKHTTNVVKAHTNRSVVE
SEQ ID No.306:
MLKVISSLLVYMTASVMAVASPLAHSGEPSGEYPTVNEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRKAGVATYASPSTRRLAEAEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSANVLYGGCAVLALSRTSAGNVADADLAEWPTSVERIQKHYPEAQFVIPGHGLPGGLDLLKHTTNVVKAHTNRSVVE
SEQ ID No.307:
MLKVISSLLVYMTASVMAVASPLAHSGEPSGEYPTVNEIPVGEVRLYQIADGVWSHISTQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEAEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSANVLYGGCAVHELSSTSAGNVADADLAEWPTSVERIQKHYPEAEVVIPGHGLPGGLDLLQHTANVVKAHKNRSVAE
SEQ ID No.308:
MLKVISSLLVYMTASVMAVASPLAHSGEPSGEYPTVNEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEAEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSANVLYGGCAVLELSRTSAGNVADADLAEWPTSVERIQKHYPEAEVVIPGHGLPGGLDLLQHTANVVKAHKNRSVAE
SEQ ID No.309:
MFKLLSKLLVYLTASIMAIASPLAFSVDSSGEYPTVNEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEVEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSASVLYGGCAIYELSRTSAGNVADADLAEWPTSIERIQQHYPEAQFVIPGHGLPGGLDLLKHTTNVVKAHTNRSVVE
SEQ ID No.310:
MLKVISSLLVYMTASVMAVASPLAHSGEPSGEYPTVNEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEAEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSANVLYGGCAVHELSSTSAGNVADADLAEWPTSVERIQKHYPEAEVVIPGHGLPGGLDLLQHTANVVKAHKNRSVAE
SEQ ID No.311:
MFQIRSFLVGISAFVMAVLGSAAYSAQPGGEYPTVDDIPVGEVRLYKIGDGVWSHIATQKLGDTVYSSNGLIVRDADELLLIDTAWGAKNTVALLAEIEKQIGLPVTRSISTHFHDDRVGGVDVLRAAGVATYTSPLTRQLAEAAGNEVPAHSLKALSSSGDVVRFGPVEVFYPGAAHSGDNLVVYVPAVRVLFGGCAVHEASRESAGNVADANLAEWPATIKRIQQRYPEAEVVIPGHGLPGGLELLQHTTNVVKTHKVRPVAE
SEQ ID No.312:
MFKLLSKLLVYLTASIMAIASPLAFSVDSSGEYPTVSEIPVGEVRLYQIADGVWSHIATRSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLANEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSASVLYGGCAIYELSRTSAGNVADADLAEWPTSIERIQQHYPEAQFVIPGHGLPGGLDLLKHTTNVVKAHTNRSVVE
SEQ ID No.313:
MLKVISSLLVYMTASVMAVASPLAHSGEPSGEYPTVNEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEAEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSANVLYGGCAVLELSSTSAGNVADADLAEWPTSVERIQKHYPEAEVVIPGHGLPGGLDLLQHTANVVKAHKNRSVAE
优选地，所述肽选自如下定义的序列为SEQ ID No.314到SEQ ID No.346的肽：
检测一种由OXA蛋白的表达引发的抗碳青霉烯和/或头孢菌素的机制，其特征在于检测至少一种选自OXA蛋白及其不同序列变体SEQ ID No.347到SEQ ID No.508的肽。
SEQ ID No.347:
MSRLLLSGLLATGLLCAVPASAASGCFLYADGNGQTLSSEGDCSSQLPPASTFKIPLALMGYDSGFLVNEEHPALPYKPSYDGWLPAWRETTTPRRWETYSVVWFSQQITEWLGMERFQQYVDRFDYGNRDLSGNPGKHDGLTQAWLSSSLAISPEEQARFLGKMVSGKLPVSAQTLQYTANILKVSEVEGWQIHGKTGMGYPKKLDGSLNRDQQIGWFVGWASKPGKQLIFVHTVVQKPGKQFASIKAKEEVLAALPAQLKKL
SEQ ID No.348:
IACLSSTALAGSITENTSWNKEFSAEAVNGVFVLCKSSSKSCATNDLARASKEYLPASTFKIPNAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLTLRGAIQVSAVPVFQQIAREVGEVRMQKYLKKFSYGNQNISGGIDKFWLEDQLRISAVNQVEFLESLYLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVEKETEVYFFAFNMDIDNESKLPLRKSIPTKIMESEGIIGG
SEQ ID No.349:
MKKILLLHMLVFVSATLPISSVASDEVETLKCTIIADAITGNTLYETGECARRVSPCSSFKLPLAIMGFDSGILQSPKSPTWELKPEYNPSPRDRTYKQVYPALWQSDSVVWFSQQLTSRLGVDRFTEYVKKFEYGNQDVSGDSGKHNGLTQSWLMSSLTISPKEQIQFLLRFVAHKLPVSEAAYDMAYATIPQYQAAEGWAVHGKSGSGWLRDNNGKINESRPQGWFVGWAEKNGRQVVFARLEIGKEKSDIPGGSKAREDILVELPVLMGNK
SEQ ID No.350:
MAIRIFAILFSIFSLATFAHAQEGTLERSDWRKFFSEFQAKGTIVVADERQADRAMLVFDPVRSKKRYSPASTFKIPHTLFALDAGAVRDEFQIFRWDGVNRGFAGHNQDQDLRSAMRNSTVWVYELFAKEIGDDKARRYLKKIDYGNAGPSTSNGDYWIEGSLAISAQEQIAFLRKLYRNELPFRVEHQRLVKDLMIVEAGRNWILRAKTGWEGRMGWWVGWVEWPTGSVFFALNIDTPNRMDDLFKREAIVRAILRSIEALPPNPAVNSDAAR
SEQ ID No.351:
MQRSLSMSGKRHFIFAVSFVISTVCLTFSPANAAQKLSCTLVIDEASGDLLHREGSCDKAFAPMSTFKLPLAIMGYDADILLDATTPRWDYKPEFNGYKSQQKPTDPTIWLKDSIVWYSQELTRRLGESRFSDYVQRFDYGNKDVSGDPGKHNGLTHAWLASSLKISPEEQVRFLRRFLRGELPVSEDALEMTKAVVPHFEAGDWDVQGKTGTGSLSDAKGGKAPIGWFIGWATRDDRRVVFARLTVGARKGEQPAGPAARDEFLNTLPALSENF
SEQ ID No.352:
MKTFAAYVIIACLSSTALAGSITENTSWNKEFSAEAVNGVFVLCKSSSKSCATNDLARASKEYLPASTFKIPNAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLTLRGAIQVSAVPVFQQIAREVGEVRMQKYLKKFSYGNQNISGGIDKFWLEGQLRISAVNQVEFLESLYLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVEKETEVYFFAFNMDIDNESKLPLRKSIPTKIMESEGIIGG
SEQ ID No.353:
IACLSSTALAGSITENTSWNKEFSAEAVNGVFVLCKSSSKSCATNDLARASKEYLPASTFKIPNAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLTLRGAIQVSAVPVFQQITREVGEVRMQKYLKKFSYGNQNISGGIDKFWLEDQLRISAVNQVEFLESLYLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVEKETEVYFFAFNMDIDNESKLPLRKSIPTKIMESEGIIGG
SEQ ID No.354:
IACLSSTALAGSITENTSWNKEFSAEAVNGVFVLCKSSSKSCATNDLARASKEYLPASTFKIPSAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLTLRGAIQVSAVPVFQQIAREVGEVRMQKYLKKFSYGNQNISGGIDKFWLEGQLRISAVNQVEFLESLYLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVEKETEVYFFAFNMDIDNESKLPLRKSIPTKIMESEGIIGG
SEQ ID No.355:
MIIRFLALLFSAVVLVSLGHAQEKTHESSNWGKYFSDFNAKGTIVVVDERTNGNSTSVYNESRAQQRYSPASTFKIPHTLFALDAGAVRDEFHVFRWDGAKRSFAGHNQDQNLRSAMRNSTVWVYQLFAKEIGENKARSYLEKLNYGNADPSTKSGDYWIDGNLAISANEQISILKKLYRNELPFRVEHQRLVKDLMIVEAKRDWILRAKTGWDGQMGWWVGWVEWPTGPVFFALNIDTPNRMEDLHKREAIARAILQSVNALPPN
SEQ ID No.356:
MAIRIFAILFSTFVFGTFAHAQEGMRERSDWRKFFSEFQAKGTIVVADERQTDRVILVFDQVRSEKRYSPASTFKIPHTLFALDAGAARDEFQVFRWDGIKRSFAAHNQDQDLRSAMRNSTVWIYELFAKEIGEDKARRYLKQIDYGNADPSTSNGDYWIDGNLAIAAQEQIAFLRKLYHNELPFRVEHQRLVKDLMIVEAGRNWILRAKTGWEGRIGWWVGWVEWPTGPVFFALNIDTPNRMDDLFKREAIVRAILRSIEALPPNPAVNSDAAR
SEQ ID No.357:
MKTFAAYVITACLSSTALASSITENTSWNKEFSAEAVNGVFVLCKSSSKSCATNNLARASKEYLPASTFKIPSAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLSLRGAIQVSAVPVFQQIAREVGEVRMQKYLKKFSYGNQNISGGIDKFWLEGQLRISAVNQVEFLESLFLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVEKGTEVYFFAFNMDIDNENKLPLRKSIPTKIMASEGIIGG
SEQ ID No.358:
MKTFAAYVITACLSSTALASSITENTSWNKEFSAEAVNGVFVLCKSSSKSCATNNLARASKEYLPASTFKIPNAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLSLRGAIQVSAVPVFQQIAREVGEVRMQKYLKKFSYGNQNISGGIDKFWLEDQLRISAVNQVEFLESLFLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVEKGTEVYFFAFNMDIDNENKLPLRKSIPTKIMASEGIIGG
SEQ ID No.359:
MKTFAAYVITACLSSTALASSITENTSWNKEFSAEAVNGVFVLCKSSSKSCATNNLARASKEYLPASTFKIPNAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLSLRGAIQVSAVPVFQQIAREVGEVRMQKYLKKFSYGNQNISGGIDKFGLEGQLRISAVNQVEFLESLFLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVEKGTEVYFFAFNMDIDNENKLPLRKSIPTKIMASEGIIGG
SEQ ID No.360:
MKNTIHINFAIFLIIANIIYSSASASTDISTVASPLFEGTEGCFLLYDASTNAEIAQFNKAKCATQMAPDSTFKIALSLMAFDAEIIDQKTIFKWDKTPKGMEIWNSNHTPKTWMQFSVVWVSQEITQKIGLNKIKNYLKDFDYGNQDFSGDKERNNGLTEAWLESSLKISPEEQIQFLRKIINHNLPVKNSAIENTIENMYLQDLDNSTKLYGKTGAGFTANRTLQNGWFEGFIISKSGHKYVFVSALTGNLGSNLTSSIKAKKNAITILNTLNL
SEQ ID No.361:
ANIIYSSASASTDISTVASPLFEGTEGCFLLYDVSTNAEIAQFNKAKCATQMAPDSTFKIALSLMAFDAEIIDQKTIFKWDKTPKGMEIWNSNHTPKTWMQFSVVWVSQEITQKIGLNKIKNYLKDFDYGNQDFSGDKERNNGLTEAWLESSLKISPEEQIQFLRKIINHNLPVKNSAIENTIENMYLQDLENSTKLYGKTGAGFTANRTLQNGWFEGFIISKSGHKYVFVSALTGNLGSNLTSSIKAKKNAITIL
SEQ ID No.362:
IFSLATFAHAQEGTLERSDWRKFFSEFQAKGTIVVADERQADRAMLVFDPVRSKKRYSPASTFKIPHTLFALDAGAVRDEFQIFRWDGVNRGFAGHNQDQDLRSAMRNSTVWVYELFAKEIGDDKARRYLKKIDYGNAYPSTSNGDYWIEGSLAISAQEQIAFLRKLYRNELPFRVEHQRLVKDLMIVEAGRNWILRAKTGWEGRMGWWVGWVEWPTGSVFFALNIDTPNRMDDLFKREAIVRAIL
SEQ ID No.363:
MIIRFLALLFSAVVLVSLGHAQDKTHESSNWGKYFSDFNAKGTIVVVDERTNGNSTSVYNESRAQQRYSPASTFKIPHTLFALDAGAVRDEFHVFRWDGAKRSFAGHNQDQNLRSAMRNSTVWVYQLFAKEIGENKARSYLEKLNYGNADPSTKSGDYWIDGNLAISANEQISILKKLYRNELPFRVEHQRLVKDLMIVEAKRDWILRAKTGWDGQMGWWVGWVEWPTGPVFFALNIDTPNRMEDLHKREAIARAILQSVNALPPN
SEQ ID No.364:
MKKFILPIFSISILVSLSACSSIKTKSEDNFHISSQQHEKAIKSYFDEAQTQGVIIIKEGKNLSTYGNALARANKEYVPASTFKMLNALIGLENHKATTNEIFKWDGKKRTYPMWEKDMTLGEAMALSAVPVYQELARRTGLELMQKEVKRVNFGNTNIGTQVDNFWLVGPLKITPVQEVNFADDLAHNRLPFKLETQEEVEKMLLIKEVNGSKIYAKSGWGMGVTPQVGWLTGWVEQANGKKIPFSLNLEMKEGMSGSIRNEITYKLLENLGII
SEQ ID No.365:
MKKFILPIFSISILVSLSACSSIKTKSEDNFHISSQQHEKAIKSYFDEAQTQGVIIIKEGKNLSTYGNALARANKEYVPASTFKMLNALIGLENHKATTNEIFKWDGKKRTYPMWEKDMTLGEAMALSAVPVYQELARRTGLELMQKEVKRVNFGNTNIGTQVDNFWLVGPLKITPVQEVNFADDLAHNRLPFKLETQEEVKKMLLIKEVNGSKIYAKSGWGMGVTPQVGWLTGWVEQANGKKIPFSLNLEMKEGMTGSIRNEITYKSLENLGII
SEQ ID No.366:
MNKYFTCYVVASLFLSGCTVQHNLINETPSQIVQGHNQVIHQYFDEKNTSGVLVIQTDKKINLYGNALSRANTEYVPASTFKMLNALIGLENQKADINEIFKWKGEKRSFTAWEKDMTLGEAMKLSAVPVYQELARRIGLDLMQKEVKRIGFGNAEIGQQVDNFWLVGPLKVTPIQEVEFVSQLAHTQLPFSEKVQANVKNMLLLEESNGYKIFGKTGWAMDIKPQVGWLTGWVEQPDGKIVAFALKMEMRSEMPASIRNELLMKSLKQLNII
SEQ ID No.367:
MAIRIFAILFSIFSLATFAHAQEGTLERSDWRKFFSEFQAKGTIVVADERQADRAMLVFDPVRSKKRYSPASTFKIPHTLFALDAGAVRDEFQIFRWDGVNRGFAGHNQDQDLRSAMRNSTVWVYELFAKEIGDDKARRYLKKIDYGNADPSTSNGDYCIEGSLAISAQEQIAFLRKLYRNELPFRVEHQRLVKDLMIVEAGRNWILRAKTGWEGRMGWWVGWVEWPTGSVFFALNIDTPNRMDDLFKREAIVRAIL
SEQ ID No.368:
MKTFAAYVITACLSSTALASSITENTSWNKEFSAEAVNGVFVLCKSSSKSCATNNLARASKEYLPASTFKIPNAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLSLRGAIQVSAVPVFQQIAREVGEVRMQKYLKKFSYGNQNISGGIDKFWLEGQLRISAVNQVEFLESLFLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVEKGTEVYFFAFNMDIDNENKLPLRKSIPTKIMASEGIIGG
SEQ ID No.369:
MAIRFLTILLSTFFLTSFVHAQEHVLERSDWKKFFSDLRAEGAIVISDERQAEHALLVFGQERAAKRYSPASTFKLPHTLFALDADAVRDEFQVFRWDGVKRSFAGHNQDQDLRSAMRNSAVWVYELFAKEIGKDKARHYLKQIDYGNADPSTIKGDYWIDGNLEISAHEQISFLRKLYRNQLPFQVEHQRLVKDLMITEAGRNWILRAKTGWEGRFGWWVGWVEWPTGPVFFALNIDTPNRTDDLFKREAIARAILRSIDALPPN
SEQ ID No.370:
MAIRIFAILFSIFSLATFAHAQEGTLERSDWRKFFSEFQAKGTIVVADERQADRAMLVFDPVRSKKRYSPASTFKIPHTLFALDAGAVRDEFQIFRWDGVNRGFAGHNQDQDLRSAMRNSTVWVYELFAKEIGDDKARRYLKKIDYGNADPSTSNGDYWIEGSIAISAQEQIAFLRKLYRNELPFRVEHQRLVKDLMIVEAGRNWILRAKTGWEGRMGWWVGWVEWPTGSVFFALNIDTPNRMDDLFKREAIVRAILRSIEALPPNPAVNSDAAR
SEQ ID No.371:
MKKFILPIFSISILVSLSACSSIKTKSEDNFHISSQQHEKAIKSYFDEAQTQGVIIIKEGKNLSTYGNALARANKEYVPASTFKMLNALIGLENHKATTNEIFKWDGKKRTYPMWEKDMTLGEAMALSAVPVYQELARRTGLELMQKEVKRVNFGNTNIGTQVDNFWLVGPLKITPVQEVNFADDLAHNRLPFKLETQEEVKKMLLIKEVNGSKIYAKSGWGMGVTPQVGWLTGWVEQANGKKIPFSLNLEMKEGMSGSIRNEITYKSLENLGII
SEQ ID No.372:
MAIRFLTILLSTFFLTSFVHAQEHVLERSDWKKFFSDLRAEGAIVISDERQAEHALLVFGQERAAKRYSPASTFKLPHTLFALDADAVRDEFQVFRWDGVKRSFAGHNQDQDLRSAMRNSAVWVYELFAKEIGEDKARRYLKQIDYGNADPSTIKGDYWIDGNLEISAHEQISFLRKLYRNQLPFQVEHQRLVKDLMITEAGRNWILRAKTGWEGRFGWWVGWVEWPTGPVFFALNIDTPNRTDDLFKREAIARAILRSIDALPPN
SEQ ID No.373:
MAIRFFTILLSTFFLTSFVYAQEHVVIRSDWKKFFSDLQAEGAIVIADERQAKHTLSVFDQERAAKRYSPASTFKIPHTLFALDADAVRDEFQVFRWDGVNRSFAGHNQDQDLRSAMRNSTVWVYELFAKDIGEDKARRYLKQIDYGNVDPSTIKGDYWIDGNLKISAHEQILFLRKLYRNQLPFKVEHQRLVKDLMITEAGRSWILRAKTGWEGRFGWWVGWIEWPTGPVFFALNIDTPNRTDDLFKREAIARAILRSIDALPPN
SEQ ID No.374:
MNKYFTCYVVASLFLSGCTVQHNLINETPSQIVQGHNQVIHQYFDEKNTSGVLVIQTDKKINLYGNALSRANTEYVPASTFKMLNALIGLENQKTDINEIFKWKGEKRSFTAWEKDMTLGEAMKLSAVPVYQELARRIGLDLMQKEVERIGFGNAEIGQQVDNFWLVGPLKVTPIQEVEFVSQLAHTQLPFSEKVQANVKNMLLLEESNGYKIFGKTGWAAMDIKPQVGWLTGWVEQPDGKIVAFALNMEMRSEMPASIRNELLMKSLKQLNII
SEQ ID No.375:
MAIQIFAILFSTFVLATFAHAQDGTLERSDWGKFFSDFQAKGTIVVADERQADHAILVFDQARSMKRYSPASTFKIPHTLFALDAGAVRDEFQIFRWDGVKRSFAGHNKDQDLRSAMRNSTVWVYELFAKEIGDGKARRYLKQIGYGNADPSTSHGDYWIEGSLAISAQEQIAFLRKLYQNDLPFRVEHQRLVKDLMIVEAGRNWILRAKTGWEGSMGWWVGWVEWPTGPVFFALNIDTPNRMDDLFKREAIARAILLSIEALPPNPAVHSDAAR
SEQ ID No.376:
MKNTIHINFAIFLIIANIIYSSASASTDISTVASQLFEGTEGCFLLYDASTNAEIAQFNKAKCAAQMAPDSTFKIALSLMAFDAEIIDQKTIFKWDKIPKGMEIWNSNHTPKTWMQFSVVWVSQEITQKIGLNKIKNYLKDFDYGNQDFSGDKERNNGLTEAWLESSLKISPEEQIQFLRKIINHNLPVRNSAIENTIDNMYLQDLENSTKLYGKTGAGFTANRTLQNGWFEGFIISKSGHKYVFVSALTGSLGSNLTSSIKAKKNAITILNTLNL
SEQ ID No.377:
MLLFMFSIISFGNENQFMKEIFERKGLNGTFVVYDLKNDKIDYYNLDRANERFYPASSFKIFNTLIGLENGIVKNVDEMFYYYDGSKVFLDSWAKDSNLRYAIKVSQVPAYKKLARELGKERMQEGLNKLNYGNKEIGSEIDKFWLEGPLKISAMEQVKLLNLLSQSKLPFKLENQEQVKDITILEKKDDFILHGKTGWATDNIVVPIGWFVGWIETSDNIYSFAINLDISDSKFLPKREEIVREYFKNINVIK
SEQ ID No.378:
MRVLALSAVFLVASIIGMPAVAKEWQENKSWNAHFTEHKSQGVVVLWNENKQQGFTNNLKRANQAFLPASTFKIPNSLIALDLGVVKDEHQVFKWDGQTRDIATWNRDHNLITAMKYSVVPVYQEFARQIGEARMSKMLHAFDYGNEDISGNVDSFWLDGGIRISATEQISFLRKLYHNKLHVSERSQRIVKQAMLTEANGDYIIRAKTGYSTRIEPKIGWWVGWVELDDNVWFFAMNMDMPTSDGLGLRQAITKEVLKQEKIIP
SEQ ID No.379:
MLSRYSKTLAFAVVACTLAISTATAHAELVVRNDLKRVFDDAGVSGTFVLMDITADRTYVVDPARAARSIHPASTFKIPNSLIAFDTGAVRDDQEVLPYGGKPQPYEQWEHDMALPEAIRLSAVPIYQEVARRVGFERMQAYVDAFDYGNRQLGSAIDQFWLRGPLEISAFEEARFTSRMALKQLPVKPRTWDMVQRMLLIEQQGDAALYAKTGVATEYQPEIGWWAGWVERAGHVYAFALNIDMPREGDMAKRIPLGKQLMRALEVWPAP
SEQ ID No.380:
MRPLLFSALLLLSGHTQASEWNDSQAVDKLFGAAGVKGTFVLYDVQRQRYVGHDRERAETRFVPASTYKVANSLIGLSTGAVRSADEVLPYGGKPQRFKAWEHDMSLRDAIKASNVPVYQELARRIGLERMRANVSRLGYGNAEIGQVVDNFWLVGPLKISAMEQTRFLLRLAQGELPFPAPVQSTVRAMTLLESGPGWELHGKTGWCFDCTPELGWWVGWVKRNERLYGFALNIDMPGGEADIGKRVELGKASLKALGILP
SEQ ID No.381:
MNKGLHRKRLSKRLLLPMLLCLLAQQTQAVAAEQTKVSDVCSEVTAEGWQEVRRWDKLFESAGVKGSLLLWDQKRSLGLSNNLSRAAEGFIPASTFKLPSSLIALETGAVRDETSRFSWDGKVREIAVWNRDQSFRTAMKYSVVPVYQQLAREIGPKVMAAMVRQLEYGNQDIGGQADSFWLDGQLRITAFQQVDFLRQLHDNKLPVSERSQRIVKQMMLTEASTDYIIRAKTGYGVRRTPAIGWWVGWLELDDNTVYFAVNLDLASASQLPLRQQLVKQVLKQEQLLP
SEQ ID No.382:
MNTIISRRWRAGLWRRLVGAVVLPATLAATPAAYAADVPKAALGRITERADWGKLFAAEGVKGTIVVLDARTQTYQAYDAARAEKRMSPASTYKIFNSLLALDSGALDNERAIIPWDGKPRRIKNWNAAMDLRTAFRVSCLPCYQVVSHKIGRRYAQAKLNEVGYGNRTIGGAPDAYWVDDSLQISAREQVDFVQRLARGTLPFSARSQDIVRQMSIVEATPDYVLHGKTGWFVDKKPDIGWWVGWIERDGNITSVAINIDMLSEADAPKRARIVKAVLKDLKLI
SEQ ID No.383:
MKTFAAYVITACLSSTALASSITENTFWNKEFSAEAVNGVFVLCKSSSKSCATNNLARASKEYLPASTFKIPNAIIGLETGVIKNEHQIFKWDGKPRAMKQWERDLSLRGAIQVSAVPVFQQIAREVGEVRMQKYLKKFSYGNQNISGGIDKFWLEGQLRISAVNQVEFLESLFLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVEKGAEVYFFAFNMDIDNENKLPLRKSIPTKIMASEGIIGG
SEQ ID No.384:
MRVLALSAVLVVASIVGMPAMANEWQEKPSWNTHFSEHKAQGVIVLWNENKQQGFTNNLKRANQAFLPASTFKIPNSLIALDLGVVKDEHQVFKWDGQTRDIAAWNRDHDLITAMKYSVVPVYQEFARQIGQARMSKMLHAFDYGNEDISGNLDSFWLDGGIRISATEQVAFLRKLYHNKLHVSERSQRIVKQAMLTEANSDYIIRAKTGYSTRIEPQIGWWVGWVELDDNVWFFAMNMDMPTADGLGLRQAITKEVLKQEKIIP
SEQ ID No.385:
MKKITLFLLFLNLVFGQDKILNNWFKEYNTSGTFVFYDGKTWASNDFSRAMETFSPASTFKIFNALIALDSGVIKTKKEIFYHYRGEKVFLSSWAQDMNLSSAIKYSNVLAFKEVARRIGIKTMQEYLNKLHYGNAKISKIDTFWLDNSLKISAKEQAILLFRLSQNSLPFSQEAMNSVKEMIYLKNMENLELFGKTGFNDGQKIAWIVGFVYLKDENKYKAFALNLDIDKFEDLYKREKILEKYLDELVKKVKNDG
SEQ ID No.386:
MSKKNFILIFIFVILISCKNTEKISNETTLIDNIFTNSNAEGTLVIYNLNDDKYIIHNKERAEQRFYPASTFKIYNSLIGLNEKAVKDVDEVFYKLMAKSFLESWAKDSNLRYAIKNSQVPAYKELARRIGIKKMKENIEKLDFGNKSIGDSVDTFWLEGPLEISAMEQVKLLTKLAQNELQYPIEIQKAISDITITRANLHITLHGKTGLADSKNMTTEPIGWFVGWLEENDNIYVFALNIDNINSDDLAKRINIVKESLKALNLLK
SEQ ID No.387:
MNKYFTCYVVASLFLSGCTVQHNLINETPSQIVQGHNQVIHQYFDEKNTSGVLVIQTDKKINLYGNALSRANTEYVPASTFKMLNALIGLENQKTDINEIFKWKGEKRSFTAWEKDMTLGEAMKLSAVPVYQELARRIGLDLMQKEVKRIGFGNAEIGQQVDNFWLVGPLKVTPIQEVEFVSQLAHTQLPFSEKVQANVKNMLLLEESNGYKIFGKTGWAMDIKPQVGWLTGWVEQPDGKIVAFALKMEMRSEMPASIRNELLMKSLKQLNII
SEQ ID No.388:
MNIQALLLITSAIFISACSPYIVTANPNYSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEKNMTLGDAMKASAIPVYQDLARRIGLELMSNEVKRIGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGISSSVRKEITYRGLEQLGIL
SEQ ID No.389:
MNIKALLLITSAIFISACSPYIVTANPNHSASKSDEKGEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSPKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.390:
MNIKALLLITSAIFISACSPYIVTANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.391:
MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.392:
MNIKALLLITSAIFISACSPYIVSANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEKNMTLGDAMKASAIPVYQDLARRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQEVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.393:
MNIKALLLITSAIFISACSPYIVTANPNHSASKSDDKAEKIKNLFNEAHTTGVLVIHQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGEKRLFPEWEKNMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.394:
MNIKALLLITSAIFISACSPYIVTANPNHSASKSDKKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWNGQKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQHEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.395:
MNIKALLLITSAIFISACSPYIVTANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKTTTTEVFKWDGQKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSPKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.396:
MNIKALLLITSAIFISACSPYIVSANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTAVFKWDGQKRLFPEWEKNMTLGDAMKASAIPVYQDLARRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGTPSSVRKEITYKSLEQLGIL
SEQ ID No.397:
MNIKALLLITSAIFISACSPYIVSANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEKNMTLGDAMKASAIPVYQDLPRRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.398:
MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEKLGIL
SEQ ID No.399:
MNIKTLLLITSTIFISACSPYIVTANPNHSTSKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASIEYVPASTFKMLNALIGLEHHKATTTEIFKWDGQKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSLKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.400:
MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAISVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLAGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.401:
MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASALPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.402:
MNIKALLLITSAIFISACSPYIVTANPNHSASKSDDKAEKIKNLFNEAHTTGVLVIHQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGEKRLFPEWEKNMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGSVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.403:
MNIKTLLLITSTIFISACSPYIVTANPNHSTSKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASIEYVPASTFKMLNALIGLEHHKATTTEIFKWDGQKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSLKAQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.404:
MNIKALLLITSAIFISACSPYIVTANPNHSASKSDKKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.405:
MNIKTLLLITSAIFISACSHYIVSANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEKNMTLGDAMKASAIPVYQDLARRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFTYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.406:
MNIKALLLITSAIFISACSPYIVSANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEKNMTLGDAMKASAIPVYQDLARRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.407:
MNIKALLLITSTIFISACSPYIVTANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALISLEHHKATTTEVFKWDGQKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.408:
MNIQALLLITSAIFISACSPYIVSANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPHGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.409:
MNIKALFLITSAIFISACSPYIVTANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.410:
MKLLKILSLVCLSISIGACAEHSMSRAKTSTIPQVNNSIIDQNVQALFNEISADAVFVTYDGQNIKKYGTHLDRAKTAYIPASTFKIANALIGLENHKATSTEIFKWDGKPRFFKAWDKDFTLGEAMQASTVPVYQELARRIGPSLMQSELQRIGYGNMQMGTEVDQFWLKGPLTITPIQEVKFVYDLAQGQLPFKPEVQQQVKEMLYVERRGENRLYAKSGWGMAVDPQVGWYVGFVEKADGQVVAFALNMQMKAGDDIALRKQLSLDVLDKLGVFHYL
SEQ ID No.411:
MNIKALLLITSTIFISACSPYIVTANPNHSTSKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEIFKWDGQKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSLKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.412:
MNIKTLLLITSAIFISACSPYIVTANPNHSASKSDEKAEKIKNLFNEVHTTGVLVIRQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSPKVQDEVQSMLFIEEMNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.413:
MKLLKILSLVCLSISIGACAEHSMSRAKTSTIPQVNNSIIDQNVQALFNEISGDAVFVTYDGQNIKKYGTHLDRAKTAYIPASTFKIANALIGLENHKATSTEIFKWDGKPRFFKAWDKDFTLGEAMQASTVPVYQELARRIGPSLMQSELQRIGYGNMQIGTEVDQFWLKGPLTITPIQEVKFVYDLAQGQLPFKPEVQQQVKEMLYVERRGENRLYAKSGWGMAVDPQVGWYVGFVEKADGQVVAFALNMQMKAGDDIALRKQLSLDVLDKLGVFHYL
SEQ ID No.414:
MKKFILPIFSISILVSLSACSSIKTKSEDNFHISSQQHEKAIKSYFDEAQTQGVIIIKEGKNLSTYGNALARANKEYVPASTFKMLNALIGLENHKATTNEIFKWDGKKRTYPMWEKDMTLGEAMALSAVPVYQELARRTGLELMQKEVKRVNFGNTNIGTQVDNFWLVGPLKITPVQEVNFADDLAHNRLPFKLETQEEVKKMLLIKEVNGSKIYAKSGWGMDVTPQVGWLTGWVEQANGKKIPFSLNLEMKEGMSGSIRNEITYKSLENLGII
SEQ ID No.415:
MAIRIFAILFSIFSLATFAHAQEGTLERSDWRKFFSEFQAKGTIVVADERQADRAMLVFDPVRSKKRYSPASTFKIPHTLFALDAGAVRDEFQIFRWDGVNRGFAGHNQDQDLRSAMRNSTVWVYELFAKEIGDDKARRYLKKIDYGNADPSTSNGDYWIESSLAISAQEQIAFLRKLYRNELPFRVEHQRLVKDLMIVEAGRNWILRAKTGWEGRMGWWVGWVEWPTGSVFFALNIDTPNRMDDLFKREAIVRAILRSIEALPPNPAVNSDAAR
SEQ ID No.416:
MNIKALLLITSAIFISACSPYIVTANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKNMTLGDAMKASAIPVYQDLARRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.417:
MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAILVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWVVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.418:
MNIKALLLITSAIFISACSPYIVTANPNHSASKSDKKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWNGQKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.419:
MNIKALLLITSAIFISACSPYIVTANPNHSASKSDDKAEKIKNLFNEAHTTGVLVIHQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGEKRLFPEWEKNMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWVVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.420:
MNIKALLLITSAIFISACSPYIVTTNPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNTDIGTQVDNFWVVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.421:
MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAIQVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.422:
MNIKALLLITSAIFISACSPYIVTANPNHSASKSDDKAEKIKNLFNEAHTTGVLVIHQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGEKRLFPEWEKNMTLGDAMKASALPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.423:
MNIKTLLLITSAIFISACSPYIVSANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSPKVQDEVQSMLFIEEMNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.424:
MNIKALLLITSAIFISACSPYIVTANPNHSASKSDDKAEKIKNLFNEAHTTGVLVIHQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGEKRLFPEWEKNMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFPLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.425:
MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGGDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.426:
MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAILVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.427:
MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWVVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.428:
MNIKALLLITSAIFISACSPYIVTANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKTTTTEVFKWDGQKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWVVGPLKITPQQEAQFAYKLANKTLPFSPKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.429:
MSKKNFILIFIFVILISCKNTEKISNETTLIDNIFTNSNAEGTLVIYNLNDDKYIIHNKERAEQRFYPASTFKIYNSLIGLNEKAVKDVDEVFYKYNGEKVFLESWAKDSNLRYAIKNSQVPAYKELARRIGLKKMKENIEKLDFGNKSIGDSVDTFWLEGPLEISAMEQVKLLTKLAQNELPYPIEIQKAVSDITILEQTYNYTLHGKTGLADSKNMTTEPIGWFVGWLEENDNIYVFALNIDNINSDDLAKRINIVKESLKALNLLK
SEQ ID No.430:
MSKKNFILIFIFVILTSCKNTEKISNETTLIDNIFTNSNAEGTLVIYNLNDDKYIIHNKERAEQRFYPASTFKIYNSLIGLNEKAVKDVDEVFYKYNGEKVFLESWAKDSNLRYAIKNSQVPAYKELARRIGLKKMKENIEKLDFGNKSIGDSVDTFWLEGPLEISAMEQIKLLTKLAQNELPYPIEIQKAVSDITILEQTYNYTLHGKTGLADSKNMTTEPIGWFVGWLEENDNIYVFALNIDNINSDDLAKRINIVKESLKALNLLK
SEQ ID No.431:
LLITSAIFISACSPYIVSANPNHSASKSDDKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEKNMTLGDAMKASAIPVYQDLARRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSL
SEQ ID No.432:
LLITSAIFISACSPYIVSANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEKNMTLGDAMKASAIPVYQDLARRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTEWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSL
SEQ ID No.433:
MTVRRLSCALGAALSLSALGGGPVQAAVLCTVVADAADGRILFQQGTQQACAERYTPASTFKLAIALMGADAGILQGPHEPVWNYQPAYPDWGGDAWRQPTDPARWIKYSVVWYSQLTAKALGQDRFQRYTSAFGYGNADVSGEPGKHNGTDGAWIISSLRISPLEQLAFLRKLVNRQLPVKAAAYELAENLFEAGQADGWRLYGKTGTGSPGSNGVYTAANAYGWFVGWARKDGRQLVYARLLQDERATRPNAGLRARDELVRDWPAMAGAWRP
SEQ ID No.434:
MNIKALLLITSAIFISACSPYIVSANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNVLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEKNMTLGDAMKASAIPVYQDLARRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQEVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.435:
MKTFAAYVIIACLSSTALAGSITENTSWNKEFSAEAVNGVFVLCKSSSKSCATNDLARASKEYLPASTFKIPSAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLTLRGAIQVSAVPVFQQIAREVGEVRMQKYLKKFSYGNQNISGGIDKFWLEDQLRISAVNQVEFLESLYLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVEKETEVYFFAFNMDIDNESKLPLRKSIPTKIMESEGIIGG
SEQ ID No.436:
MNIKTLLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWVVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.437:
MNIKALLLITSAIFISACSPYIVTTNPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNTDIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.438:
MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAVPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNQQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.439:
MNIKTLLLITSAIFISACSPYIVTANPNHSASKSDEKAEKIKNLFNEVHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSPKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEMTYKSLEQLGIL
SEQ ID No.440:
MNKYFTCYVVASLFFSGCTVQHNLINETQSQIVQGHNQVIHQYFDEKNTSGVLVIQTDKKINLYGNALSRANTEYVPASTFKMLNALIGLENQKTDINEIFKWKGEKRSFTTWEKDMTLGEAMKLSAVPVYQELARRIGLDLMQKEVERIDFGNAEIGQQVDNFWLIGPLKVTPIQEVEFVSQLAHTQLPFSEKVQANVKNMLLLEENNGYKIFGKTGWAMDIKPQVGWLTGWVEQPDGKIVAFALNMEMRSEMPASIRNELLMKSLKQLNII
SEQ ID No.441:
MNKYFTCYVVASLFLSGCTVQHNLINETPSQIVQGHNQVIHQYFDEKNTSGVLVIQTDKKINLYGNALSRANTEYVPASTFKMLNALIGLENQKTDINEIFKWKGEKRSFTAWEKDMTLGEAMKLSAVPVYQELARRIGLDLMQKEVKRIGFGNAEIGQQVDNFWLVGPLKVTPIQEVEFVSQLAHTQLPFSEKVQANVKNMLLLEESNGYKIFGKTGWAAMDIKPQVGWLTGWVEQPDGKIVAFALNMEMRSEMPASIRNELLMKSLKQLNII
SEQ ID No.442:
MKTFAAYVITACLSSTALASSITENTSWNKEFSAEAVNGVFVLCKSSSKSCATNNLARASKEYLPASTFKIPNAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLSLRGAIQVSAVPVFQQIAREVGEVRMQKYLKKFSYGNQNISGGIDKFLLEGQLRISAVNQVEFLESLFLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVEKGTEVYFFAFNMDIDNENKLPLRKSIPTKIMASEGIIGG
SEQ ID No.443:
MAIRIFAILFSIFSLATFAHAQEGTLERSDWRKFFSEFQAKGTIVVADERQADRAMLVFDPVRSKKRYSPASTFKIPHTLFALDAGAVRDEFQIFRWDGVNRGFAGHNQDQDLRSAMRNSTVWVYELFAKEIGDDKARRYLKKIDYGDADPSTSNGDYWIEGSLAISAQEQIAFLRKLYRNELPFRVEHQRLVKDLMIVEAGRNWILRAKTGWEGRMGWWVGWVEWPTGSVFFALNIDTPNRMDDLFKREAIVRAILRSIEALPPNPAVNSDAAR
SEQ ID No.444:
MNIKALLLITSAIFISACSPYIVTANPNHSASKSDKKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKASTTEVFKWNGQKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVKSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.445:
MNIKALLLITSAIFISACSPYIVSANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEKNMTLGDAMKASAIPVYQDLARRIGLELMSNEVKHVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSPKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.446:
MNIKALLLITSAIFISACSPYIVSANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEKNMTLGDAMKASAIPVYQDLARRIGLELMSNEVKHVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.447:
MKKFILPILSISTLLSVSACSSIQTKFEDTFHTSNQQHEKAIKSYFDEAQTQGVIIIKKGKNISTYGNNLTRAHTEYVPASTFKMLNALIGLENHKATTTEIFKWDGKKRSYPMWEKDMTLGDAMALSAVPVYQELARRTGLDLMQKEVKRVGFGNMNIGTQVDNFWLVGPLKITPIQEVNFADDFANNRLPFKLETQEEVKKMLLIKEFNGSKIYAKSGWGMDVTPQVGWLTGWVEKSNGEKVAFSLNIEMKQGMPGSIRNEITYKSLENLGII
SEQ ID No.448:
MNIKALLLITSAIFISACSPYIVSANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEKNMTLGDAMKASAIPVYQDLARRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQEVQDEVQSILFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.449:
MKKFILPIFSISILVSLSACSSIKTKSEDNFHISSQQHEKAIKSYFDEAQTQGVIIIKEGKNLSTYGNALARANKEYVPASTFKMLNALIGLENHKATTNEIFKWDGKKRTYPMWEKDMTLGEAMALSAVPVYQELARRTGLELMQKEVKRVNFGNTNIGTQVDNFWLVGPLKITPVQEVNFADDLAHNRLPFKLETQEEVKKMLLIKEVNGSKIYAKSGWGMGVTSQVGWLTGWVEQANGKKIPFSLNLEMKEGMSGSIRNEITYKSLENLGII
SEQ ID No.450:
MRVLALSAVFLVASIIGMPAVAKEWQENKSWNAHFTEHKSQGVVVLWNENKQQGFTNNLKRANQAFLPASTFKIPNSLIALDLGVVKDEHQVFKWDGQTRDIATWNRDHNLITAMKYSVVPVYQEFARQIGEARMSKMLHAFDYGNEDISGNVDSFWLDGGIRISATEQISFLRKLYHNKLHVSERSQRIVKQAMLTEANGDYIIRAKTGYSARIEPKIGWWVGWVELDDNVWFFAMNMDMPTSDGLGLRQAITKEVLKQEKIIP
SEQ ID No.451:
MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAVPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGLDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.452:
MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAVPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGLDVNLQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.453:
MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWVVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEKLGIL
SEQ ID No.454:
MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIRNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWVVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.455:
MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDSKKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWVVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.456:
MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWVVGPLKITPQQEAQFAYKLANKTLPFSQKVQDGVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.457:
MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDSKKRLFPEWEKDMTLGDAMKASAILVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.458:
MKLLKILSLVCLSISIGACAEHSMSRAKTSTIPQVNNSIIDQNVQALFNEISADAVFVTYDGQNIKKYGTHLDRAKTAYIPASTFKIANALIGLENHKATSTEIFKWDGKPRFLKAWDKDFTLGEAMQASTVPVYQELARRIGPSLMQSELQRIGYGNMQIGTEVDQFWLKGPLTITPIQEVKFVYDLAQGQLPFKPEVQQQVKEMLYVERRGENRLYAKSGWGMAVDPQVGWYVGFVEKADGQVVAFALNMQMKAGDDIALRKQLSLDVLDKLGVFHYL
SEQ ID No.459:
MNKYFTCYVVASLFLSGCTVQHNLINETPSQIVQGHNQVIHQYFDEKNTSGVLVIQTDKKINLYGNALSRANTEYVPASTFKMLNALIGLENQKTDINEIFKWKGEKRSFTAWEKDMTLGEAMKLSAVPVYQELARRIGLDLMQKEVKRIGFGNAEIGQQVDNFWLVGPLKVTPIQEVEFVSQLAHTQLPFSEKVQANVKNMLLLEESNGYKIFGKTGWAMDVKPQVGWLTGWVEQPDGKIVAFALNMEMRSEMPASIRNELLMKSLKQLNII
SEQ ID No.460:
MNKYFTCYVVASLFLSGCTVQHNLINETPSQIVQGHNQVIHQYFDEKNTSGALVIQTDKKINLYGNALSRANTEYVPASTFKMLNALIGLENQKTDINEIFKWKGEKRSFTAWEKDMTLGEAMKLSAVPVYQELARRIGLDLMQKEVKRIGFGNAEIGQQVDNFWLVGPLKVTPIQEVEFVSQLAHTQLPFSEKVQANVKNMLLLEESNGYKIFGKTGWAMDIKPQVGWLTGWVEQPDGKIVAFALNMEMRSEMPASIRNELLMKSLKQLNII
SEQ ID No.461:
MNKYFTCYVVASLFLSGCTVQHNLINETPSQIVQGHNQVIHQYFDEKNTSGVLVIQTDKKINLYGNALSRANTEYVPASTFKMLNALIGLENQKTDINEIFKWKGEKRSFTAWEKDMTLGEAMKLSAVPVYQELARRIGLDLMQKEVKRIGFGNAEIGQQVDNFWLVGPLKVTPIQEVEFVSQLAHTQLPFSEKVQANVKNMLLLEESNGYKIFGKTGWAMDIKPQVGWLTGWVEQPDGKIVAFALNMEMRSEMPASIRNELMMKSLKQLNII
SEQ ID No.462:
MNKYFTCYVVASLFLSGCTVQHNLINETPSQIVQGHNQVIHQYFDEKNTSGVLVIQTDKKINLYGNALSRANTEYVPASTFKMLNALIGLENQKTDINEIFKWKGEKRSFTAWEKDMTLGEAMKLSAVPVYQELARRIGLDLMQKEVKRIGFGNAEIGQQVDNFWLVGPLKVTPIQEVEFVSQLAHTQLPFSEKVQANVKNMLLLEESNGYKIFGKTGWAMDIKPQVGWLAGWVEQPDGKIVAFALNMEMRSEMPASIRNELLMKSLKQLNII
SEQ ID No.463:
MNKYFTCYVVASLFLSGCTVQHNLINETPSQIVQGHNQVIHQYFDERNTSGVLVIQTDKKINLYGNALSRANTEYVPASTFKMLNALIGLENQKTDINEIFKWKGEKRSFTAWEKDMTLGEAMKLSAVPVYQELARRIGLDLMQKEVKRIGFGNAEIGQQVDNFWLVGPLKVTPIQEVEFVSQLAHTQLPFSEKVQANVKNMLLLEESNGYKIFGKTGWAMDIKPQVGWLTGWVEQPDGKIVAFALNMEMRSEMPASIRNELLMKSLKQLNII
SEQ ID No.464:
MNKYFTCYVVASLFLSGCTVQHNLINETPSQIVQGHNQVIHQYFDEKNTSGVLVIQTDKKINLYGNALSRANTEYVPASTFKMLNALIGLENQKTDINEIFKWKGEKRSFTAWEKDMTLGEAMKLSAVPVYQELARRIGLDLMQKEVKRIGFGNAEIGQQVDNFWLVGPLKVTPIQEVEFVSQLAHTQLPFSEKVQANVKNMLLLEKSNGYKIFGKTGWAMDIKPQVGWLTGWVEQPDGKIVAFALNMEMRSEMPASIRNELLMKSLKQLNII
SEQ ID No.465:
MNKYFTCYVVASLFLSGCTVQHNLINETPSQIVQGHNQVIHQYFDEKNTSGVLVIQTDKKINLYGNALSRANTEYVPASTFKMLNALIGLENQKTDINEIFKWKGEKRSFTAWEKDMTLGEAMKLSAVPVYQELARRIGLDLMQKEVKRIGFGNAEIGQQVDNFWLVGPLKVTPIQEVEFVSQLAHTQLPFSEKVQANVKNMLLLEESNGYKIFGKTGWAMDIKPQVGWLTGWVEQPDGKIVAFALNMEMRSEMPASTRNELLMKSLKQLNII
SEQ ID No.466:
MKKFILPIFSISILLSLSACSSIQTKFEDTFHISNQKHEKAIKSYFDEAQTQGVIIIKEGKNISSYGNNLVRAHTEYVPASTFKMLNALIGLENHKATTNEIFKWDGKKRSYPMWEKDMTLGEAMALSAVPVYQDLARRIGLNLMQKEVKRVGFGNMNIGTQVDNFWLIGPLKITPIQEVNFADDLANNRLPFKLETQEEVKKMLLIKEVNGSKIYAKSGWGMDVSPQVGWLTGWVEKSNGEKVSFSLNIEMKQGMSGSIRNEITYKSLENLGII
SEQ ID No.467:
MNIKALLLITSAIFISACSPYIVTANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEKDMTLGDAMKASAIAVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSPKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.468:
MNIKALLLITSAIFISACSPYIVTANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEKDMTLGDAIKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.469:
MKILIFLPLLSCLGLTACSLPVSSLPSQSISTQAIASLFDQAQSSGVLVIQRDQQVQVYGNDLNRANTEYVPASTFKMLNALIGLQHGKATTNEIFKWDGKKRSFTAWEKDMTLGQAMQASAVPVYQELARRIGLELMQQEVQRIQFGNQQIGQQVDNFWLVGPLKVTPKQEVQFVSALAREQLAFDPQVQQQVKAMLFLQERKAYRLYVKSGWGMDVEPQVGWLTGWVETPQAEIVAFSLNMQMQNGIDPAIRLEILQQALAELGLYPKAEG
SEQ ID No.470:
MHKHMSKLFIAFLAFLLSVPAAAEDQTLAELFAQQGIDGTIVISSLHNGKTFIHNDPRAKQRFSTASTFKILNTLISLEEKAISGKDDVLKWDGHIYDFPDWNRDQTLESAFKVSCVWCYQALARQVGAEKYRNYLRKSVYGELREPFEETTFWLDGSLQISAIEQVNFLKKVHLRTLPFSASSYETLRQIMLIEQTPAFTLRAKTGWATRVKPQVGWYVGHVETPTDVWFFATNIEVRDEKDLPLRQKLTRKALQAKGIIE
SEQ ID No.471:
MKTFAAYVITACLSSTALASSITENTSWNKEFSAEAVNGVFVLCKSSSKSCATNNLARASKEYLPASTFKIPNAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLSLRGAIQVSAVPVFQQIAREVGEVRMQKYLKKFSYGNQNISGGTDKFWLEDQLRISAVNQVEFLESLFLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVEKGTEVYFFAFNMDIDNENKLPLRKSIPTKIMASEGIIGG
SEQ ID No.472:
MNIKALLLITSAIFISACSPYIVTANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAILVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGLDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.473:
MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAIQVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWVVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.474:
MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAMPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.475:
MNIKALLLITSAIFISACSPYIVTANPNHSASKSDEKAEKIKNLFNEVHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKNMTLGDAMKASAIPVYQDLARRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.476:
MRVLALSAVFLVASIIGMPAVAKEWQENKSWNAHFTEHKSQGVVVLWNENKQQGFTNNLKRANQAFLPASTFKIPNSLIALDLGVVKDEHQVFKWDGQTRDIATWNRDHNLITAMKYSVVPVYQEFARQIGEARMSKMLHAFDYGNEDISGNVDSFWLDGGIRISATEQISFLRKLYHNKLHVSERSQRIVKQAMLTEANGDYIIRAKTGYDTKIGWWVGWVELDDNVWFFAMNMDMPTSDGLGLRQAITKEVLKQEKIIP
SEQ ID No.477:
MSKKNFILIFIFVILISCKNTEKTSNETTLIDNIFTNSNAEGTLVIYNLNDDKYIIHNKERAEQRFYPASTFKIYNSLIGLNEKAVKDVDEVFYKYNGEKVFLESWAKDSNLRYAIKNSQVPAYKELARRIGLEKMKENIEKLDFGNKNIGDSVDTFWLEGPLEISAMEQVKLLTKLAQNELPYPIEIQKAVSDITILEQTDNYTLHGKTGLADSENMTTEPIGWLVGWLEENNNIYVFALNIDNINSDDLAKRINIVKESLKALNLLK
SEQ ID No.478:
MNIKALFLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWVVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.479:
MNIKALFLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWVVGPLKITPQQEAQFAYKLANKTLPSSQKVQDEVQSMLFIEEKNGNKMYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.480:
MNIKALFLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWVVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEIAYKSLEQLGIL
SEQ ID No.481:
MAIRIFAILFSIFSLATFAHAQEGTLERSDWRKFFSEFQAKGTIVVADERQADRAMLVFDPVRSKKRYSPASTFKIPHTLFALDAGAVRDEFQIFRWDGVNRGFAGHNQDQDLRSAMRNSTVWVYELFAKEIGDDKARRYLKKIDYGNADPSTSNGDCWIEGSLAISAQEQIAFLRKLYRNELPFRVEHQRLVKDLMIVEAGRNWILRAKTGWEGRMGWWVGWVEWPTGSVFFALNIDTPNRMDDLFKREAIVRAILRSIEALPPNPAVNSDAAR
SEQ ID No.482:
MNIKTLLLITSAIFISACSPYIVTANPNHSASKSDEKAEKIKNLFNEVHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWVVGPLKITPQQEAQFAYKLANKTLPFSPKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.483:
MNIKTLLLITSAIFISACSPYIVTANPNHSASKSDEKAEKIKNLFNEVHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEYHKATTTEVFKWDGQKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSPKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.484:
MAIRFLTILLSTFFLTSFVHAQEHVVVRSDWKKFFSDLQAEGAIVIADERQAEHALLVFGQERAAKRYSPASTFKLPHTLFALDAGAVRDEFQVFRWDGVKRSFAGHNQDQDLRSAMRNSAVWVYELFAKEIGEDNARRYLKQIDYGNADPSTIKGNYWIDGNLEISAHEQISFLRKLYRNQLPFQVEHQRLVKYLMITEAGRNWILRAKTGWEGRFGWWIGWVEWPTGPVFFALNIDTPNRTDDLFKREAIARAILRSIDALPPN
SEQ ID No.485:
MRVLALSAVFLVASIIGMPAVAKEWQENKSWNAHFTEHKSQGVVVLWNENKQQGFTNNLKRANQAFLPASTFKIPNSLIALDLGVVKDEHQVFKWDGQTRDIAAWNRDHDLITAMKYSVVPVYQEFARQIGEARMSKMLHAFDYGNEDISGNVDSFWLDGGIRISATQQIAFLRKLYHNKLHVSERSQRIVKQAMLTEANGDYIIRAKTGYSTRIEPKIGWWVGWVELDDNVWFFAMNMDMPTSDGLGLRQAITKEVLKQEKIIP
SEQ ID No.486:
MNKYFTCYVVASLFLSGCTVQHNLINETPSQIVQGHNQVIHQYFDEKNTSGVLVIQTDKKINLYGNALSRANTEYVPASTFKMLNALIGLENQKTDINEIFKWKGEKRSFTAWEKDMTLGEAMKLSAVPVYQELARRIGLDLMQKEVKRIGFGNAEIGQQVDNFWLVGPLKVTPIQEVEFVSQLAHTQLPFSEKVQANVKNMLLLEESNGYKIFGKTGWAMDIKSQVGWLTGWVEQPDGKIVAFALNMEMRSEMPASIRNELLMKSLKQLNII
SEQ ID No.487:
MNIKALLLITSAIFISACSPYIVTANPNHSASKSDVKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAISVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.488:
MAIRIFAILFSIFSLATFAHAQEGTLERSDWRKFFSEFQAKGTIVVADERQADRAMLVFDPVRSKKRYSPASTFKIPHTLFALDAGAVRDEFQIFRWDGVNRGFAGHNQDQDLRSAMRNSTVWVYELFAKEIGDDKARRYLKKIDYGNADPSTSNGDYWIEGSLAISAQEQIAFLRKLYRNELPFRVEHQRLVKDLMIVEAGRNWILRAKTGWEGRMGWWVGWVEWPTGSVFFALNIDTPNRMDDLFKREAIVRAILRSIEALPPNPAVNSDAAR
SEQ ID No.489:
MKTIAAYLVLVFYASTALSESISENLAWNKEFSSESVHGVFVLCKSSSNSCTTNNAARASTAYIPASTFKIPNALIGLETGAIKDERQVFKWDGKPRAMKQWEKDLKLRGAIQVSAVPVFQQIAREVGEIRMQKYLNLFSYGNANIGGGIDKFWLEGQLRISAFNQVKFLESLYLNNLPASKANQLIVKEAIVTEATPEYIVHSKTGYSGVGTESSPGVAWWVGWVEKGTEVYFFAFNMDIDNESKLPSRKSISTKIMASEGIIIGG
SEQ ID No.490:
MKTFAAYVITACLSSTALASSITENTFWNKEFSAEAVNGVFVLCKSSSKLACATNNLARASKEYLPASTFKIPNAIIGLETGVIKNEHQIFKWDGKPRAMKQWERDLSLRGAIQVSAVPVFQQIAREVGEVRMQKYLKKFSYGNQNISGGIDKFWLEGQLRISAVNQVEFLESLFLNKLSASKENQLIVKEALVTEAPEYLVHSKTGFSGVGTESNPGVAWWVGWVEKGAEVYFFAFNMDIDNENKLPLRKSIPTKIMASEGIIGG
SEQ ID No.491:
MAIRIFAILFSTFVFGTFAHAQEGMRERSDWRKFFSEFQAKGTIVVADERQTDRVILVFDQVRSEKRYSPASTFKIPHTLFALDAGAARDEFQVFRWDGIKRSFAAHNQDQDLRSAMRNSTVWIYELFAKEIGEDKARRYLKQIDYGNADPSTSNGDYWIDGNLAIAAQEQIAFLRKLYHNELPFRVEHQRLVKDLMIVEAGRNWILRAKTGWEGRMGWWVGWVEWPTGPVFFALNIDTPNRMDDLFKREAIVRAILRSIEALPPNPAVNSDAAR
SEQ ID No.492:
MKTFAAYVIIACLSSTALAGSITENTSWNKEFSAEAVNGVFVLCKSSSKSCATNDLARASKEYLPASTFKIPNAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLTLRGAIQVSAVPVFQQIAREVGEVRMQKYLKKFSYGSQNISGGIDKFWLEDQLRISAVNQVEFLESLYLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVEKETEVYFFAFNMDIDNESKLPLRKSIPTKIMESEGIIGG
SEQ ID No.493
MNKYFTCYVVASLFLSGCTVQHNLINETPSQIVQGHNQVIHQYFDEKNTSGVLVIQTDKKINLYGNALSRANTEYVPASTFKMLNALIGLENQKTDINEIFKWKGEKRSFTAWEKDMTLGEAMKLSAVPVYQELARRIGLDLMQKEVKRIGFGNAEIGQQVDNFWLVGPLKVTPIQEVEFVSQLAHTQLPFSEKVQANVKNMLLLEESNGYKIFGKTGWAMDIKPQVGWLTGWVEQPDGKIVAFALNMEMRSEMPASIRNELLMKSLKQLNII
SEQ ID No.494
MKKLSVLLWLTLFYCGTIWAQSTCFLVQENQTVLKHEGKDCNKRFAPESTFKIALSLMGFDSGILKDTLNPEWPYKKEYELYLNVWKYPHNPRTWIRDSCVWYSQVLTQQLGMTRFKNYVDAFHYGNQDISGDKGQNNGLTHSWLSSSLAISPSEQIQFLQKIVNKKLSVNPKAFTMTKDILYIQELAGGWKLYGKTGNGRQLTKDKSQKLSLQHGWFIGWIEKDGRVITFTKHIADSKKHVTFASFRAKNETLNQLFYLINELEK
SEQ ID No.495
MNIKTLLLITSAIFISACSPYIVTANPNHSASKSDEKAEKIKNLFNEVHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSPKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.496
MKFRHALSSAFVLLGCIAASAHAKTICTAIADAGTGKLLVQDGDCGRRASPASTFKIAISLMGYDAGFLRNEHDPVLPYRDSYIAWGGEAWKQPTDPTRWLKYSVVWYSQQVAHHLGAQRFAQYAKAFGYGNADVSGDPGQNNGLDRAWIGSSLQISPLEQLEFLGKMLNRKLPVSPTAVDMTERIVESTTLADGTVVHGKTGVSYPLLADGTRDWARGSGWFVGWIVRGNQTLVFARLTQDERKQPVSAGIRTREAFLRDLPRLLAAR
SEQ ID No.497
MKFRHALSSAFVLLGCIAASAHAKTICTAIADAGTGKLLVQDGDCGRRASPASTFKIAISLMGYDAGFLRNEHDPVLPYRDSYIAWGGEAWKQPTDPTRWLKYPVVWYSQQVAHHLGAQRFAQYAKAFGYGNADVSGDPGQNNGLDRAWIGSSLQISPLEQLEFLGKMLNRKLPVSPTAVDMTERIVESTTLADGTVVHGKTGVSYPLLADGTRDWARGSGWFVGWIVRGKQTLVFARLTQDERKQPVSAGIRTREAFLRDLPRLLAAR
SEQ ID No.498
MRGKHTVILGAALSALFAGAAGAQMLECTLVADAASGQELYRKGACDKAFAPMSTFKVPLAVMGYDAGILVDAHNPRWDYKPEFNGYKFQQKTTDPTIWEKDSIVWYSQQLTRKMGQKRFAAYVAGFGYGNGDISGEPGKSNGLTHSWLGSSLKISPEGQVRFVRDLLSAKLPASKDAQQMTVSILPHFAAGDWAVQGKTGTGSFIDARGAKAPLGWFIGWATHEERRVVFARMTAGGKKGEQPAGPAARDAFLKALPDLAKRF
SEQ ID No.499
MKFRHALSSAFVLLGCIAASAHAKTICTAIADAGTGKLLVQDGDCGRRASPASTFKIAISLMGYDAGFLRNEHDPVLPYRDSYIAWGGEAWKQPTDPTRWLKYSVVWYSQQVAHHLGAQRFAQYAKAFGYGNADVSGDPGQNNGLDRAWIGSSLQISPLEQLEFLGKMLDRKLPVSPTAVDMTERIVESTTLADGTVVHGKTGVSYPLLADGTRDWARGSGWFVGWIVRGKQTLVFARLTQDERKQPVSAGIRTREAFLRDLPRLLAAR
SEQ ID No.500
MKFRHALSSAFVLLGCIAASAHAKTICTAIADAGTGKLLVQDGDCGRRASPASTFKIAISLMGYDAGFLRNEHDPVLPYRDSYIAWGGEAWKQPTDPTRWLKYSVVWYSQQVAHHLGAQRFAQYAKAFGYGNADVSGDPGQNNGLDRAWIGSSLQISPLEQLEFLGKMLNRKLPVSPTAVDMTERIVESTTLADGTVVHGKTGVSYPLLADGTRDWARGSGWFVGWIVRGKQTLVFARLTQDERKQPVSAGIRTREAFLRDLPRLLAAR
SEQ ID No.501
MKTFAAYVIIACLSSTALAGSITENTSWNKEFSAEAVNGVFVLCKSSSKSCATNDLARASKEYLPVSTFKIPSAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLTLRGAIQVSAVPVFQQIAREVGEVRMQKYLKKFSYGNQNISGGIDKFWLEGQLRISAVNQVEFLESLYLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVEKETEVYFFAFNMDIDNESKLPLRKSIPTKIMESEGIIGG
SEQ ID No.502
MNIKALLLITSAIFISACSPYIVTANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGKKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.503
MNIKALLLITSAIFISACSPYIVSANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEKNMTLGDAMKASAIPVYQDLARRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVNPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.504
MKTFAAYVITACLSSTALASSITENTFWNKEFSAEAVNGVFVLCKSSSKSCATNNLARASKEYLPASTFKIPNAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLSLRGAIQVSAVPVFQQIAREVGEVRMQKYLKKFSYGNQNISGGIDKFWLEGQLRISAVNQVEFLESLFLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVEKGTEVYFFAFNMDIDNENKLPLRKSIPTKIMASEGIIGG
SEQ ID No.505
MKTIAAYLVLVFFAGTALSESISENLAWNKEFSSESVHGVFVLCKSSSNSCTTNNATRASTAYIPASTFKIPNALIGLETGAIKDARQVFKWDGKPRAMKQWEKDLTLRGAIQVSAVPVFQQIARDIGKKRMQKYLNLFSYGNANIGGGIDKFWLEGQLRISAVNQVKFLESLYLNNLPASKANQLIVKEAIVTEATPEYIVHSKTGYSGVGTESNPGVAWWVGWVEKGTEVYFFAFNMDIDNESKLPSRKSIPTKIMASEGIIIGG
SEQ ID No.506
MKKFILPIFSISILVSLSACSSIKTKSEDNFHISSQQHEKAIKSYFDEAQTQGVIIIKEGKNLSTYGNALARANKEYVPASTFKMLIALIGLENHKATTNEIFKWDGKKRTYPMWEKDMTLGEAMALSAVPVYQELARRTGLELMQKEVKRVNFGNTNIGTQVDNFWLVGPLKITPVQEVNFADDLAHNRLPFKLETQEEVKKMLLIKEVNGSKIYAKSGWGMGVTPQVGWLTGWVEQANGKKIPFSLNLEMKEGMSGSIRNEITYKSLENLGII
SEQ ID No.507
MNIKALLLITSAIFISACSPYIVTANPNHSASKSDDKAEKIKNLFNEAHTTGVLVIHQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWNGQKRLFPEWEKDMTLGDAMKASAIPVYQDLARRIGLELMSNEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
SEQ ID No.508
MNIKALLLITSAISISACSPYIVTANPNHSASKSDEKAEKIKNLFNEAHTTGVLVIQQGQTQQSYGNDLARASTEYVPASTFKMLNALIGLEHHKATTTEVFKWDGQKRLFPEWEKDMTLGDAIKASAIPVYQDLARRIGLELMSKEVKRVGYGNADIGTQVDNFWLVGPLKITPQQEAQFAYKLANKTLPFSQKVQDEVQSMLFIEEKNGNKIYAKSGWGWDVDPQVGWLTGWVVQPQGNIVAFSLNLEMKKGIPSSVRKEITYKSLEQLGIL
优选地，所述肽选自如下定义的序列为SEQ ID No.509到SEQ ID No.523、SEQ IDNo.525到SEQ ID No.572、SEQ ID No.574到SEQ ID No.604、SEQ ID No.606到SEQ IDNo.618、SEQ ID No.620到SEQ ID No.696、SEQ ID No.698到SEQ ID No.1077、SEQ IDNo.1098到SEQ ID No.1109的肽：
在临床意义栏，2d、2de和2df条目对应OXA β-内酰胺酶功能亚组，而相应的肽可以检测所述酶。因此，检测到2df肽将证明能够水解碳青霉烯的碳青霉烯酶β-内酰胺酶的存在。
2de条目将证明存在能够超广谱(ESBL)的水解青霉素、诸如头孢菌素Ⅱ和头孢噻吩的第一代头孢菌素和至少一种来自诸如头孢噻肟、头孢他啶的氧亚氨基β-内酰胺或诸如氨曲南的单环β-内酰胺类的抗菌剂的β-内酰胺酶。
OXA条目证明在亚组2d、2de和2df中的至少两组之间的一种普通肽。相应的肽证明存在OXA β-内酰胺酶以及存在至少针对青霉素和第一代头孢菌素的抗性机制。
检测OXA蛋白引发的针对碳青霉烯的抗性机制的特征在于检测选自序列为SEQ IDNo.510、511、512、513、514、520、521、522、523、525、527、530、532、537、541、542、543、544、545、546、547、548、549、550、551、552、556、557、558、559、560、561、562、574、579、581、582、583、584、592、596、597、598、599、600、601、602、607、608、609、628、631、632、633、635、636、644、646、647、649、650、655、656、661、662、667、674、675、682、689、690、698、713、714、719、720、722、727、729、730、741、746、748、750、751、752、755、756、757、758、763、764、767、768、772、775、781、782、790、792、793、794、795、796、797、798、801、809、811、812、813、814、816、819、824、832、834、837、838、847、851、852、853、854、855、856、857、858、859、860、862、868、869、870、874、875、876、877、879、880、881、882、894、895、898、902、903、904、906、907、908、911、912、913、914、915、919、920、922、923、927、929、937、938、939、945、946、948、949、950、951、954、956、957、959、962、964、967、969、971、972、974、975、979、980、985、988、990、993、994、995、996、997、1000、1001、1002、1003、1004、1005、1006、1007、1011、1013、1015、1017、1018、1019、1023、1027、1030、1032、1033、1034、1035、1036、1037、1038、1039、1040、1042、1047、1048、1051、1052、1057、1058、1060、1070、1098、1099、1100、1101、1102、1103、1104、1105、1106、1107、1108、1109的至少一种抗性标记carba肽。
某些肽序列在一些抗性机制中是共同的。因此，下列序列是相同的：
SEQ ID No.24和SEQ ID No.287。
在所有实施方式中，上述序列代表存在针对青霉素、头孢菌素(包括第三代，例如头孢噻肟和头孢他啶)、单环β-内酰胺类和碳青霉烯的抗性机制的表达。
本说明书后续部分给出的所述方法的非限制性的实施例将显现本发明的方法及其进步。
实施例1：以生物化学特征谱(Biochemical profile)从样品中鉴别微生物
1.在培养基上培养样品
根据微生物的种，最适培养基和最适培养条件是不同的。默认样品接种在不同的培养基上：
○绵羊血Columbia琼脂(bioMérieux ref.43041)，在35℃，有氧或无氧的气氛下培养18到24小时；
○TSA琼脂(bioMérieux ref.43011)，在37℃培养18到24小时。
2.鉴别微生物
鉴别进行如下：
1.选择分离的克隆
2.在无菌条件下，将3mL灭菌的盐水溶液(0.45-0.50％NaCl、pH 4.5-7.0)移到透明的塑料(聚苯乙烯)检测管
3.使用搅拌棒或灭菌的棉签，将足够数量的克隆移到第2步制备的盐溶液管中，以来自于的有刻度的DENSICHEK调节细菌悬液处于0.50到0.63McFarland之间
4.将细菌悬液管和鉴别卡置于卡盘(cartridge)上
5.将卡盘放入到仪器中
6.填装、密封、孵育和读出操作是自动的
7.获得生物化学特征谱
8.通过与已知菌株的生物化学特征谱比较，以系统进行鉴别
实施例2：通过微生物富集制备初级尿样
以下的方案分16步进行(第5到12步可选，如果富集的样品接着会根据实施例4起的方法处理，则可以将其略去)：
1.以2000g离心5ml受污染的尿液30秒
2.收取上清
3. 15000g离心5分钟
4.弃上清
5.以3mL蒸馏水重悬洗涤沉淀
6. 15000g离心5分钟
7.弃上清
8.将沉淀置于溶剂(丙酮v:甲醇v＝8:1)中做1/10稀释
9.-20℃静止1小时
10. 15000g离心5分钟
11.弃上清
12.将沉淀置于溶剂(丙酮v:甲醇v＝8:1)中做1/10稀释
13.-20℃静止1小时
14. 15000g离心5分钟
15.弃上清
16.沉淀组成了微生物富集的样品
实施例3：以MALDI-TOF鉴别来自样品的微生物
鉴别进行如下：
1.移取添加了1μl白金耳的一份根据实施例1获得的微生物克隆或根据实施例2获得的富集样品，并均匀沉积在MALDI-TOF质谱的盘上
2.以1μl基质覆盖沉积物。所用基质为HCCA(alpha-cyano-4-hydroxycinnamicacid)的有机溶剂(50％乙腈和2.5％三氟乙酸)饱和溶液
3.室温下干燥
4.将盘置于质谱仪中
5.获得质谱
6.将获得的谱与已知库中的谱对比
7.比较获得的峰和已知库中的峰以鉴别微生物
实施例4：以ESI-TOF鉴别样品中的微生物
鉴别进行如下：
1.获得根据实施例1获得的微生物克隆或根据实施例2获得的富集样品的样品，并悬浮在100μl蒸馏水中
2. 3000g离心5min
3.弃上清
4.重悬于100μl蒸馏水中
5. 3000g离心5min
6.弃上清
7.重悬于100μl乙腈、蒸馏水和甲酸(50/50/0.1％)混合液
8.以孔径0.45μm的滤器过滤
9.在单MS模式下注入质谱仪
10.获得质谱
11.将获得的谱与已知库中的谱对比
12.参考对照谱以鉴别微生物
实施例5:从微生物中获得消化的蛋白
下面的方法通常分17步进行：
1.获得根据实施例1获得的微生物克隆或根据实施例2获得的富集样品的样品，并悬浮在10到100μl 6M盐酸胍溶液(含50mM Tris-HCl，pH＝8.0)
2.加入二硫苏糖醇(DTT)，终浓度达到5mM
3. 95℃水浴还原20分钟
4.管在室温下冷却
5.加入碘乙酰胺，终浓度达到12.5mM
6.室温下避光烷基化40分钟
7.以50mM NH4HCO3溶液(pH＝8.0)稀释6倍，获得盐酸胍终浓度1M
8.加入1μg胰蛋白酶
9. 37℃消化6小时到一夜
10.加入甲酸至pH低于4以终止反应
11.以含0.5％体积甲酸的水定容样品体积到1mL
12.以1mL甲醇，再以1mL含0.1％体积甲酸的水平衡Waters Oasis HLB柱
13.样品在重力下沉积
14.以1mL含0.1％体积甲酸的水洗涤
15.以1mL混合液(80％甲醇和20％含0.1％体积甲酸的水)洗脱
16.以SPD2010蒸发器(Thermo Electron Corporation、Waltham、Massachusetts、United States of America)浓缩洗脱液2小时以上，以获得约100μL的体积
17.然后将洗脱液置于不少于250μL含0.5％体积甲酸的水溶液中
实施例6：鉴别对NDM-1 β-内酰胺的抗性
根据实施例1、3或4中的一个的方法鉴别样品Sam1到Sam9。菌种的鉴别在表1中列出。
表1：
名称 菌种
Sam1 肺炎克雷伯菌
Sam2 C.freundii
Sam3 鲍氏不动杆菌
Sam4 A.caviae
Sam5 C.braakii
Sam6 阴沟肠杆菌
Sam7 P.rettgeri
Sam8 大肠杆菌
Sam9 肺炎克雷伯菌
样品Sam1到Sam9对应含有NDM-1抗性机制(微肠杆菌科，假单胞菌，不动杆菌等)。然后用以下方法搜索该机制。
根据实施例5处理每个样品，然后体积为50μL的消化的蛋白根据如下情况被注入和分析：
·来自于Dionex公司(Sunnyvale、United States of America)的DionexUltimate 3000层析通道。
·Waters BEH130C18柱，内径2.1mm，长100mm，粒径3.5μm(Waters、Saint-QuentinEn Yvelines、France)。
·溶剂A：水+0.1％甲酸。
·溶剂B：ACN+0.1％甲酸。
HPLC梯度定义于后续的表2：
表2：
时间(分) 流量(μl) 溶剂A(％) 溶剂B(％)
0 300 98 2
3 300 98 2
34 300 54.6 45.4
35 300 0 100
55 300 0 100
55.1 300 98 2
74 300 98 2
·来自于层析通道的洗脱液直接注入Applied Biosystems(Foster City、UnitedStates of America)的5500质谱仪的电离源。
·来自于微生物蛋白消化的肽用质谱仪以MRM模式分析。只有表3中的肽被检测到。有鉴于此，表3中的碎片被检测到。
表3：
前体肽的电荷状态、保留时间、碎片离子类型和转换即Q1中的(m/z)1和Q3中的(m/z)2在表3中显示。表3中还显示了用于打碎前体离子的碰撞能。
·其他使用的机器参数如下：
测量每个转换和每个研究的微生物的获得的面积。认为面积大于等于2500(任意单位)的所有转换是阳性的并且在表4中标记1。认为面积小于2500的所有转换是阴性的并且在表4中标记0。如果没观察到信号峰，转换被标记为阴性。
表4：
转换编号 Sam1 Sam2 Sam3 Sam4 Sam5 Sam6 Sam7 Sam8 Sam9
1 1 1 1 1 1 1 0 1 1
2 1 1 1 1 1 1 1 1 1
3 1 1 0 1 1 1 0 1 1
4 1 1 1 1 1 1 1 1 1
5 1 1 1 1 1 1 1 1 1
6 1 1 0 1 1 1 1 1 1
7 0 0 0 0 0 0 0 0 0
8 0 0 0 0 0 0 0 0 0
9 0 0 0 0 0 0 0 0 0
10 1 1 1 1 1 1 1 1 1
11 1 1 1 1 1 1 1 1 1
12 1 1 1 1 1 1 1 1 1
13 0 0 0 0 0 0 0 0 0
14 0 0 0 0 0 0 0 0 0
15 0 0 0 0 0 0 0 0 0
16 1 1 0 1 1 0 0 0 1
17 1 1 0 1 1 1 1 0 1
18 1 1 0 1 1 0 1 0 1
19 0 0 0 0 0 0 0 0 0
20 0 0 0 0 0 0 0 0 0
21 0 0 0 0 0 0 0 0 0
22 0 0 0 0 0 0 0 0 0
23 0 0 0 0 0 0 0 0 0
24 0 0 0 0 0 0 0 0 0
然后将阳性转换的数量相加并在表5中列出：
表5：
名称 菌种 阳性转换数
Sam1 肺炎克雷伯菌 12
Sam2 C.freundii 12
Sam3 鲍氏不动杆菌 7
Sam4 A.caviae 12
Sam5 C.braakii 12
Sam6 阴沟肠杆菌 10
Sam7 P.rettgeri 9
Sam8 大肠杆菌 9
Sam9 肺炎克雷伯菌 12
样品Sam1到Sam9包含多于6个阳性转换，因此它们含有表达NDM-1蛋白的细菌。于是，Sam1到Sam9的细菌抗青霉素、头孢菌素和碳青霉烯。
实施例7：鉴别对KPC β-内酰胺的抗性：
根据实施例1、3或4中的一个的方法鉴别样品Sam62到Sam73。菌种的鉴别在表6中列出。
表6：
名称 菌种
Sam62 肺炎克雷伯菌
Sam63 肺炎克雷伯菌
Sam64 肺炎克雷伯菌
Sam65 肺炎克雷伯菌
Sam66 肺炎克雷伯菌
Sam67 肺炎克雷伯菌
Sam68 肺炎克雷伯菌
Sam69 肺炎克雷伯菌
Sam70 肺炎克雷伯菌
Sam71 肺炎克雷伯菌
Sam72 肺炎克雷伯菌
Sam73 肺炎克雷伯菌
样品Sam62到Sam73对应包含KPC抗性机制的菌种。以如下方法检测其机制。
根据实施例5处理每个样品，然后根据实施例6检测表7中的肽代替表3中的肽进行分析。
表7：
使用表8中列出的参数检测表7中提到的转换。
表8：
测量每个转换和每个所研究的微生物获得的面积。当同一个肽的三个转换的面积大于或等于表8中描述的阳性阈值时，认为肽的检测为阳性，并在表9中标记为“1”。当至少一个转换包含小于表8中描述的阳性阈值的面积时，认为没有检测到相应的肽，并在表9中标记为“0”。
表9：
样品Sam68到Sam73包含至少一个KPC特征性转换。因此，样品Sam68到Sam73中的细菌表达β-内酰胺酶，这给予这些样品对青霉素、头孢菌素(包括诸如头孢噻肟和头孢他啶的第三代头孢菌素)、单环β-内酰胺和碳青霉烯的抗性。
样品Sam62到Sam67不含有KPC特征性转换。因此，样品Sam62到Sam67中的细菌不表达KPCβ-内酰胺酶，可能对碳青霉烯类抗生素敏感。
实施例8：鉴别对NDM-1或KPC β-内酰胺的抗性：
对应包含NDM-1或KPC抗性机制的中的样品可以采用如下方法检测。
根据实施例5处理每个样品，然后根据实施例6检测表10中的肽代替表3中的肽进行分析。
表10：
2f条目显示存在来自于2f亚组(根据Bush和Jacoby分类[Antimicrob AgentsChemother.2010Mar；54(3):969-76.Epub 2009Dec 7.Updated functionalclassification of beta-lactamases.])的能水解碳青霉烯的碳青霉烯酶β-内酰胺酶。
3a条目显示存在来自于3a亚组(根据Bush和Jacoby分类[9])的能水解上述青霉素、头孢菌素和碳青霉烯的金属β-内酰胺酶。
以表11中列出的参数检测表10中提到的转换。
表11：
当同一个肽的至少两个转换的面积大于或等于表11中描述的阳性阈值时，认为肽段检测是阳性的。当多于两个同一个肽的转换的面积小于表11中描述的阳性阈值时，认为没有检测到相应的肽。
当检测到至少一种对应于NDM-1抗性机制的肽时，样品中含有表达NDM-1蛋白的细菌。这些细菌抗青霉素、头孢菌素和碳青霉烯。
当检测到至少一种对应于KPC抗性机制的肽时，样品中含有表达KPC蛋白的细菌。这些细菌抗青霉素、头孢菌素(包括诸如头孢噻肟和头孢他啶的第三代头孢菌素)、单环β-内酰胺和碳青霉烯。
实施例9：鉴别对IND β-内酰胺的抗性:
根据实施例1、3或4中的一个的方法鉴别样品Sam84到Sam88。种的鉴别在表12中列出。
表12：
名称 菌种
Sam84 C.indologenes
Sam85 C.indologenes
Sam86 C.indologenes
Sam87 C.indologenes
Sam88 C.indologenes
样品Sam84到Sam88对应包含IND抗性机制的菌种。然后用以下方法检测该机制。
根据实施例5处理每个样品，然后根据实施例6(除非在本实施例剩下的部分中另作说明)检测表13中的肽代替表3中的肽进行分析。
表13：
所用的其他机器参数如下：
测量每个转换和每个所研究的微生物的所获得的面积。当转换的面积大于或等于表13中描述的阳性阈值时，认为转换的检测是阳性的，并在表14中标记为“1”。当转换的面积小于表13中描述的阳性阈值时，认为没有检测到转换，并在表14中标记为“0”。
对于一个给定的肽，当至少三个转换被标记为“1”时，认为检测到该肽。
表14：
样品Sam84到Sam88含有至少一个IND特征性肽。因此，样品Sam84到Sam88中存在的细菌表达β-内酰胺酶，这赋予它们对青霉素、头孢菌素和碳青霉烯的抗性。
实施例10：鉴别对GES β-内酰胺的抗性：
根据实施例1、3或4中的一个的方法鉴别样品Sam89和Sam90。种的鉴别在表15中列出。
表15：
名称 菌种
Sam89 大肠杆菌
Sam90 绿脓假单胞菌
样品Sam89和Sam90对应含有GES抗性机制的菌种。然后以如下方法检测该机制。
根据实施例5处理每个样品，然后根据实施例6(除非在本实施例剩下的部分中另作说明)检测表16中的肽代替表3中的肽进行分析。
表16：
所用的其他机器参数如下：
测量每个转换和每个所研究的微生物的所获得的面积。当转换的面积大于或等于表16中描述的阳性阈值时，认为转换的检测是阳性的，并在表17中标记为“1”。当转换的面积小于表16中描述的阳性阈值时，认为没有检测到转换，并在表17中标记为“0”。
对于一个给定的肽，当至少三个转换被标记为“1”时，认为检测到该肽。
表17：
样品Sam89和Sam90包含至少一个碳青霉烯酶表型的特征性肽。因此，存在于样品Sam89和Sam90中的细菌表达β-内酰胺酶，这赋予其对青霉素、头孢菌素和碳青霉烯的抗性。
实施例11：鉴别对SME β-内酰胺的抗性：
根据实施例1、3或4的方法鉴别样品Sam91到Sam95。菌种的鉴别在表18中列出。
表18：
名称 菌种
Sam91 S.marcescens
Sam92 S.marcescens
Sam93 S.marcescens
Sam94 S.marcescens
Sam95 S.marcescens
样品Sam91到Sam95对应含有SME抗性机制的菌种。然后以如下方法检测该机制。
根据实施例5处理每个样品，然后根据实施例6(除非在本实施例剩下的部分中另作说明)检测表19中的肽代替表3中的肽进行分析。
表19：
所用的其他机器参数如下：
测量每个转换和每个所研究的微生物的所获得的面积。当转换的面积大于或等于表19中描述的阳性阈值时，认为转换的检测是阳性的，并在表20中标记为“1”。当转换的面积小于表19中描述的阳性阈值时，认为没有检测到转换，并在表20中标记为“0”。
对于一个给定的肽，当至少三个转换被标记为“1”时，认为检测到该肽。
表20：
样品Sam91到Sam95包含至少一个碳青霉烯酶表型的特征性肽。因此，存在于样品Sam91到Sam95中的细菌表达β-内酰胺酶，这赋予其对青霉素、头孢菌素和碳青霉烯的抗性。
实施例12：鉴别对IMPβ-内酰胺的抗性：
样品对应的含有IMP抗性的菌种可以用如下的方法检测。
根据实施例5处理每个样品，然后根据实施例6检测表21中的肽代替表3中的肽进行分析。
表21：
测量每个转换和每个所研究的微生物的所获得的面积。当转换的面积大于或等于2500时，认为肽的检测是阳性的，并标记为“1”。当至少一个转换的面积小于2500时，认为没有检测到对应的肽，并标记为“0”。
实施例13：鉴别对KPC β-内酰胺的抗性：
样品对应的含有KPC抗性的菌种可以用如下的方法检测。
根据实施例5处理每个样品，然后根据实施例6检测表22中的肽代替表3中的肽进行分析。
表22：
测量每个转换和每个所研究的微生物的所获得的面积。当转换的面积大于或等于2500时，认为肽的检测是阳性的，并标记为“1”。当至少一个转换的面积小于2500时，认为没有检测到对应的肽，并标记为“0”。
实施例14：鉴别对NDM β-内酰胺的抗性：
样品对应的含有NDM抗性的菌种可以用如下的方法检测。
根据实施例5处理每个样品，然后根据实施例6检测表23中的肽代替表3中的肽进行分析。
表23：
测量每个转换和每个所研究的微生物的所获得的面积。当转换的面积大于或等于2500时，认为肽的检测是阳性的，并标记为“1”。当至少一个转换的面积小于2500时，认为没有检测到对应的肽，并标记为“0”。
实施例15：鉴别对VIM β-内酰胺的抗性：
样品对应的含有NDM抗性的菌种可以用如下的方法检测。
根据实施例5处理每个样品，然后根据实施例6检测表24中的肽代替表3中的肽进行分析。
表24：
测量每个转换和每个所研究的微生物的所获得的面积。当转换的面积大于或等于2500时，认为肽的检测是阳性的，并标记为“1”。当至少一个转换的面积小于2500时，认为没有检测到对应的肽，并标记为“0”。
实施例16：鉴别对OXAβ-内酰胺的抗性：
样品对应的含有OXA抗性的菌种可以用如下的方法检测。
根据实施例5处理每个样品，然后根据实施例6检测表25中的肽代替表3中的肽进行分析。
表25：
测量每个转换和每个所研究的微生物的所获得的面积。当转换的面积大于或等于2500时，认为肽的检测是阳性的，并标记为“1”。当至少一个转换的面积小于2500时，认为没有检测到对应的肽，并标记为“0”。
实施例17：鉴别对IMP β-内酰胺的抗性:
根据实施例1、3或4中的一个的方法鉴别样品Sam145到Sam154。种的鉴别在表26中列出。
表26：
名称 种
Sam145 鲍氏不动杆菌
Sam146 鲍氏不动杆菌
Sam147 大肠杆菌
Sam148 肺炎克雷伯菌
Sam149 肺炎克雷伯菌
Sam150 绿脓假单胞菌
Sam151 绿脓假单胞菌
Sam152 绿脓假单胞菌
Sam153 绿脓假单胞菌
Sam154 P.putida
样品Sam145到Sam154对应包含IMP抗性机制的菌种。然后用以下方法检测该机制。
根据实施例5处理每个样品，然后根据实施例6(除非在本实施例剩下的部分中另作说明)检测表27中的肽代替表3中的肽进行分析。
表27：
所用的其他机器参数如下：
测量每个转换和每个所研究的微生物的所获得的面积。当转换的面积大于或等于表27中描述的阳性阈值时，认为转换的检测是阳性的，并在表28中标记为“1”。当转换的面积小于表27中描述的阳性阈值时，认为没有检测到转换，并在表28中标记为“0”。
对于一个给定的肽，当至少三个转换被标记为“1”时，认为检测到该肽。
表28：
样品Sam145到Sam154包含至少一个IMP的特征性肽。因此，存在于样品Sam145到Sam154中的细菌表达β-内酰胺酶，这赋予其对青霉素、头孢菌素和碳青霉烯的抗性。
实施例18：鉴别对OXA-48 β-内酰胺的抗性:
根据实施例1、3或4中的一个的方法鉴别样品Sam155到Sam164。种的鉴别在表29中列出。
表29：
样品Sam155到Sam164对应包含OXA-48抗性机制的菌种。然后用以下方法检测该机制。
根据实施例5处理每个样品，然后根据实施例6(除非在本实施例剩下的部分中另作说明)检测表30中的肽代替表3中的肽进行分析。
表30：
所用机器的其他参数如下：
测量每个转换和每个所研究的微生物的所获得的面积。当转换的面积大于或等于表30中描述的阳性阈值时，认为转换的检测是阳性的，并在表31中标记为“1”。当转换的面积小于表30中描述的阳性阈值时，认为没有检测到转换，并在表31中标记为“0”。
对于一个给定的肽，当至少三个转换被标记为“1”时，认为检测到该肽。
表31：
样品Sam155到Sam164包含至少一个OXA-48组的特征性肽。因此，存在于样品Sam155到Sam164中的细菌表达β-内酰胺酶，这赋予其对青霉素、第一代和第二代头孢菌素(不对广谱的头孢菌素)和碳青霉烯的抗性。
实施例19：鉴别对VIM β-内酰胺的抗性:
根据实施例1、3或4中的一个的方法鉴别样品Sam165到Sam170。菌种的鉴别在表32中列出。
表32：
名称 菌种
Sam165 绿脓假单胞菌
Sam166 大肠杆菌
Sam167 鲍氏不动杆菌complex
Sam168 A.junii
Sam169 大肠杆菌
Sam170 肺炎克雷伯菌肺炎亚种
样品Sam165到Sam170对应包含VIM抗性机制的菌种。然后用以下方法检测该机制。
根据实施例5处理每个样品，然后根据实施例6(除非在本实施例剩下的部分中另作说明)检测表33中的肽代替表3中的肽进行分析。
表33：
所使用的其他机器参数如下：
测量每个转换和每个所研究的微生物的所获得的面积。当转换的面积大于或等于表33中描述的阳性阈值时，认为转换的检测是阳性的，并在表34中标记为“1”。当转换的面积小于表33中描述的阳性阈值时，认为没有检测到转换，并在表34中标记为“0”。
对于一个给定的肽，当至少三个转换被标记为“1”时，认为检测到该肽。
表34：
样品Sam165到Sam170包含至少一个VIM组的特征性肽。因此，存在于样品Sam165到Sam170中的细菌表达β-内酰胺酶，这赋予其对青霉素、头孢菌素和碳青霉烯的抗性。
在实施例6到11中描述的检测方法尤其有效，因为它们可以检测大量的肽，同时检测一种或多种碳青霉烯酶引发的一种或多种抗性机制的存在。
进一步，检测进行时间短，少于一小时。事实上，只有3到34分钟之间的梯度部分对分析是有用的。进一步，检测的肽的保留时间都在34分钟以下。
另外，实施例6到11描述的检测方法比分子生物学方法更有效，因为它们检测基因表达的产物，而不是基因本身。如果基因不表达，或者表达太弱不足以带来有效的抗性，抗性的检测可能没有任何临床意义。检测抗性机制的特征蛋白的特征性肽则没有这个缺点。
令人意外的是，上述实施例显示，用质谱可以获得特异性检测样品中微生物对至少一种抗菌剂的抗性机制的存在所必需的敏感性，而不需要采用分子生物学方法所常用扩增方法。
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Ser Glu Ala Val Ile Ala Ala Ala Ala Arg Leu Ala Leu Glu Gly Leu
275 280 285
Gly Val Asn Gly Gln
290
<210> 15
<211> 293
<212> PRT
<213> RESISTANCE GENE
<400> 15
Met Ser Leu Tyr Arg Arg Leu Val Leu Leu Ser Cys Leu Ser Trp Pro
1 5 10 15
Leu Ala Gly Phe Ser Ala Thr Ala Leu Thr Asn Leu Val Ala Glu Pro
20 25 30
Phe Ala Lys Leu Glu Gln Asp Phe Gly Gly Ser Ile Gly Val Tyr Ala
35 40 45
Ile Asp Thr Gly Ser Gly Ala Thr Val Ser Tyr Arg Ala Glu Glu Arg
50 55 60
Phe Pro Leu Cys Ser Ser Phe Lys Gly Phe Leu Ala Ala Ala Val Leu
65 70 75 80
Ala Arg Ser Gln Gln Gln Ala Gly Leu Leu Asp Thr Pro Ile Arg Tyr
85 90 95
Gly Lys Asn Ala Leu Val Pro Trp Ser Pro Ile Ser Glu Lys Tyr Leu
100 105 110
Thr Thr Gly Met Thr Val Ala Glu Leu Ser Ala Ala Ala Val Gln Tyr
115 120 125
Ser Asp Asn Ala Ala Ala Asn Leu Leu Leu Lys Glu Leu Gly Gly Pro
130 135 140
Ala Gly Leu Thr Ala Phe Met Arg Ser Ile Gly Asp Thr Thr Phe Arg
145 150 155 160
Leu Asp Arg Trp Glu Leu Glu Leu Asn Ser Ala Ile Pro Gly Asp Ala
165 170 175
Arg Asp Thr Ser Ser Pro Arg Ala Val Thr Glu Ser Leu Gln Lys Leu
180 185 190
Thr Leu Gly Ser Ala Leu Ala Ala Pro Gln Arg Gln Gln Phe Val Asp
195 200 205
Trp Leu Lys Gly Asn Thr Thr Gly Asn His Arg Ile Arg Ala Ala Val
210 215 220
Pro Ala Asp Trp Ala Val Gly Asp Lys Thr Gly Thr Cys Gly Val Tyr
225 230 235 240
Gly Thr Ala Asn Asp Tyr Ala Val Val Trp Pro Thr Gly Arg Ala Pro
245 250 255
Ile Val Leu Ala Val Tyr Thr Arg Ala Pro Asn Lys Asp Asp Lys Tyr
260 265 270
Ser Glu Ala Val Ile Ala Ala Ala Ala Arg Leu Ala Leu Glu Gly Leu
275 280 285
Gly Val Asn Gly Gln
290
<210> 16
<211> 293
<212> PRT
<213> RESISTANCE GENE
<400> 16
Met Ser Leu Tyr Arg Arg Leu Val Leu Leu Ser Cys Leu Ser Trp Pro
1 5 10 15
Leu Ala Gly Phe Ser Ala Thr Ala Leu Thr Asn Leu Val Ala Glu Pro
20 25 30
Phe Ala Lys Leu Glu Gln Asp Phe Gly Gly Ser Ile Gly Val Tyr Ala
35 40 45
Met Asp Thr Gly Ser Gly Ala Thr Val Ser Tyr Arg Ala Glu Glu Arg
50 55 60
Phe Pro Leu Cys Ser Ser Phe Lys Gly Phe Leu Ala Ala Ala Val Leu
65 70 75 80
Ala Arg Ser Gln Gln Gln Ala Gly Leu Leu Asp Thr Pro Ile Arg Tyr
85 90 95
Gly Lys Asn Ala Leu Val Pro Trp Ser Pro Ile Ser Glu Lys Tyr Leu
100 105 110
Thr Thr Gly Met Thr Val Ala Glu Leu Ser Ala Ala Ala Val Gln Tyr
115 120 125
Ser Asp Asn Ala Ala Ala Asn Leu Leu Leu Lys Glu Leu Gly Gly Pro
130 135 140
Ala Gly Leu Thr Ala Phe Met Arg Ser Ile Gly Asp Thr Thr Phe Arg
145 150 155 160
Leu Asp Arg Trp Glu Leu Glu Leu Asn Ser Ala Ile Pro Gly Asp Ala
165 170 175
Arg Asp Thr Ser Ser Pro Arg Ala Val Thr Glu Ser Leu Gln Lys Leu
180 185 190
Thr Leu Gly Ser Ala Leu Ala Ala Pro Gln Arg Gln Gln Phe Val Asp
195 200 205
Trp Leu Lys Gly Asn Thr Thr Gly Asn His Arg Ile Arg Ala Ala Val
210 215 220
Pro Ala Asp Trp Ala Val Gly Asp Lys Thr Gly Thr Cys Gly Gly Tyr
225 230 235 240
Gly Thr Ala Asn Asp Tyr Ala Val Val Trp Pro Thr Gly Arg Ala Pro
245 250 255
Ile Val Leu Ala Val Tyr Thr Arg Ala Pro Asn Lys Asp Asp Lys Tyr
260 265 270
Ser Glu Ala Val Ile Ala Ala Ala Ala Arg Leu Ala Leu Glu Gly Leu
275 280 285
Gly Val Asn Gly Gln
290
<210> 17
<211> 289
<212> PRT
<213> RESISTANCE GENE
<400> 17
Met Ser Leu Tyr Arg Arg Leu Val Leu Leu Ser Cys Leu Ser Trp Pro
1 5 10 15
Leu Ala Gly Phe Ser Ala Thr Ala Leu Thr Asn Leu Val Ala Glu Pro
20 25 30
Phe Ala Lys Leu Glu Gln Asp Phe Gly Gly Ser Ile Gly Val Tyr Ala
35 40 45
Met Asp Thr Gly Ser Gly Ala Thr Val Ser Tyr Arg Ala Glu Glu Arg
50 55 60
Phe Pro Leu Cys Ser Ser Phe Lys Gly Phe Leu Ala Ala Ala Val Leu
65 70 75 80
Ala Arg Ser Gln Gln Gln Ala Gly Leu Leu Asp Thr Pro Ile Arg Tyr
85 90 95
Gly Lys Asn Ala Leu Val Pro Trp Ser Pro Ile Ser Glu Lys Tyr Leu
100 105 110
Thr Thr Gly Met Thr Val Ala Glu Leu Ser Ala Ala Ala Val Gln Tyr
115 120 125
Ser Asp Asn Ala Ala Ala Asn Leu Leu Leu Lys Glu Leu Gly Gly Pro
130 135 140
Ala Gly Leu Thr Ala Phe Met Arg Ser Ile Gly Asp Thr Thr Phe Arg
145 150 155 160
Leu Asp Arg Trp Glu Leu Glu Leu Asn Ser Ala Ile Pro Gly Asp Ala
165 170 175
Arg Asp Thr Ser Ser Pro Arg Ala Val Thr Glu Ser Leu Gln Lys Leu
180 185 190
Thr Leu Gly Ser Ala Leu Ala Ala Pro Gln Arg Gln Gln Phe Val Asp
195 200 205
Trp Leu Lys Gly Asn Thr Thr Gly Asn His Arg Ile Arg Ala Ala Val
210 215 220
Pro Ala Asp Trp Ala Val Gly Asp Lys Thr Gly Thr Cys Gly Ala Tyr
225 230 235 240
Gly Thr Ala Asn Asp Tyr Ala Val Val Trp Pro Thr Gly Arg Ala Pro
245 250 255
Ile Val Leu Ala Val Tyr Thr Arg Ala Pro Asn Lys Asp Asp Lys Tyr
260 265 270
Ser Glu Ala Val Ile Ala Ala Ala Ala Arg Leu Ala Leu Glu Gly Leu
275 280 285
Gly
<210> 18
<211> 293
<212> PRT
<213> RESISTANCE GENE
<400> 18
Met Ser Leu Tyr Arg Arg Leu Val Leu Leu Ser Cys Leu Ser Trp Pro
1 5 10 15
Leu Ala Gly Phe Ser Ala Thr Ala Leu Thr Asn Leu Val Ala Glu Pro
20 25 30
Phe Ala Lys Leu Glu Gln Asp Phe Gly Gly Ser Ile Gly Val Tyr Ala
35 40 45
Met Asp Thr Gly Ser Gly Ala Thr Val Ser Tyr Arg Ala Glu Glu Arg
50 55 60
Phe Pro Leu Cys Ser Ser Phe Lys Gly Phe Leu Ala Ala Ala Val Leu
65 70 75 80
Ala Arg Ser Gln Gln Gln Ala Gly Leu Leu Asp Thr Pro Ile Arg Tyr
85 90 95
Gly Lys Asn Ala Leu Val Arg Trp Ser Pro Ile Ser Glu Lys Tyr Leu
100 105 110
Thr Thr Gly Met Thr Val Ala Glu Leu Ser Ala Ala Ala Val Gln Tyr
115 120 125
Ser Asp Asn Ala Ala Ala Asn Leu Leu Leu Lys Glu Leu Gly Gly Pro
130 135 140
Ala Gly Leu Thr Ala Phe Met Arg Ser Ile Gly Asp Thr Thr Phe Arg
145 150 155 160
Leu Asp Arg Trp Glu Leu Glu Leu Asn Ser Ala Ile Pro Gly Asp Ala
165 170 175
Arg Asp Thr Ser Ser Pro Arg Ala Val Thr Glu Ser Leu Gln Lys Leu
180 185 190
Thr Leu Gly Ser Ala Leu Ala Ala Pro Gln Arg Gln Gln Phe Val Asp
195 200 205
Trp Leu Lys Gly Asn Thr Thr Gly Asn His Arg Ile Arg Ala Ala Val
210 215 220
Pro Ala Asp Trp Ala Val Gly Asp Lys Thr Gly Thr Cys Gly Val Tyr
225 230 235 240
Gly Thr Ala Asn Asp Tyr Ala Val Val Trp Pro Thr Gly Arg Ala Pro
245 250 255
Ile Val Leu Ala Val Tyr Thr Arg Ala Pro Asn Lys Asp Asp Lys Tyr
260 265 270
Ser Glu Ala Val Ile Ala Ala Ala Ala Arg Leu Ala Leu Glu Gly Leu
275 280 285
Gly Val Asn Gly Gln
290
<210> 19
<211> 293
<212> PRT
<213> RESISTANCE GENE
<400> 19
Met Ser Leu Tyr Arg Arg Leu Val Leu Leu Ser Cys Leu Ser Trp Pro
1 5 10 15
Leu Ala Gly Phe Ser Ala Thr Ala Leu Thr Asn Leu Val Ala Glu Pro
20 25 30
Phe Ala Lys Leu Glu Gln Asp Phe Gly Gly Ser Ile Gly Val Tyr Ala
35 40 45
Met Asp Thr Gly Ser Gly Ala Thr Val Ser Tyr Arg Ala Glu Glu Arg
50 55 60
Phe Pro Leu Cys Ser Ser Phe Lys Gly Phe Leu Ala Ala Ala Val Leu
65 70 75 80
Ala Arg Ser Gln Gln Gln Ala Gly Leu Leu Asp Thr Pro Ile Arg Tyr
85 90 95
Gly Lys Asn Ala Leu Val Leu Trp Ser Pro Ile Ser Glu Lys Tyr Leu
100 105 110
Thr Thr Gly Met Thr Val Ala Glu Leu Ser Ala Ala Ala Val Gln Tyr
115 120 125
Ser Asp Asn Ala Ala Ala Asn Leu Leu Leu Lys Glu Leu Gly Gly Pro
130 135 140
Ala Gly Leu Thr Ala Phe Met Arg Ser Ile Gly Asp Thr Thr Phe Arg
145 150 155 160
Leu Asp Arg Trp Glu Leu Glu Leu Asn Ser Ala Ile Pro Gly Asp Ala
165 170 175
Arg Asp Thr Ser Ser Pro Arg Ala Val Thr Glu Ser Leu Gln Lys Leu
180 185 190
Thr Leu Gly Ser Ala Leu Ala Ala Pro Gln Arg Gln Gln Phe Val Asp
195 200 205
Trp Leu Lys Gly Asn Thr Thr Gly Asn His Arg Ile Arg Ala Ala Val
210 215 220
Pro Ala Asp Trp Ala Val Gly Asp Lys Thr Gly Thr Cys Gly Val Tyr
225 230 235 240
Gly Thr Ala Asn Asp Tyr Ala Val Val Trp Pro Thr Gly Arg Ala Pro
245 250 255
Ile Val Leu Ala Val Tyr Thr Arg Ala Pro Asn Lys Asp Asp Lys His
260 265 270
Ser Glu Ala Val Ile Ala Ala Ala Ala Arg Leu Ala Leu Glu Gly Leu
275 280 285
Gly Val Asn Gly Gln
290
<210> 20
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 20
Ala Ala Val Pro Ala Asp Trp Ala Val Gly Asp Lys
1 5 10
<210> 21
<211> 10
<212> PRT
<213> RESISTANCE GENE
<400> 21
Ala Pro Ile Val Leu Ala Val Tyr Thr Arg
1 5 10
<210> 22
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 22
Ala Val Thr Glu Ser Leu Gln Lys
1 5
<210> 23
<211> 13
<212> PRT
<213> RESISTANCE GENE
<400> 23
Glu Leu Gly Gly Pro Ala Gly Leu Thr Ala Phe Met Arg
1 5 10
<210> 24
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 24
Phe Pro Leu Cys Ser Ser Phe Lys
1 5
<210> 25
<211> 10
<212> PRT
<213> RESISTANCE GENE
<400> 25
Gly Phe Leu Ala Ala Ala Val Leu Ala Arg
1 5 10
<210> 26
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 26
Gly Asn Thr Thr Gly Asn His Arg
1 5
<210> 27
<211> 11
<212> PRT
<213> RESISTANCE GENE
<400> 27
Leu Ala Leu Glu Gly Leu Gly Val Asn Gly Gln
1 5 10
<210> 28
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 28
Leu Thr Leu Gly Ser Ala Leu Ala Ala Pro Gln Arg
1 5 10
<210> 29
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 29
Asn Ala Leu Val Pro Trp Ser Pro Ile Ser Glu Lys
1 5 10
<210> 30
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 30
Gln Gln Phe Val Asp Trp Leu Lys
1 5
<210> 31
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 31
Ser Ile Gly Asp Thr Thr Phe Arg
1 5
<210> 32
<211> 13
<212> PRT
<213> RESISTANCE GENE
<400> 32
Ser Gln Gln Gln Ala Gly Leu Leu Asp Thr Pro Ile Arg
1 5 10
<210> 33
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 33
Trp Glu Leu Glu Leu Asn Ser Ala Ile Pro Gly Asp Ala Arg
1 5 10
<210> 34
<211> 287
<212> PRT
<213> RESISTANCE GENE
<400> 34
Met Arg Phe Ile His Ala Leu Leu Leu Ala Gly Ile Ala His Ser Ala
1 5 10 15
Tyr Ala Ser Glu Lys Leu Thr Phe Lys Thr Asp Leu Glu Lys Leu Glu
20 25 30
Arg Glu Lys Ala Ala Gln Ile Gly Val Ala Ile Val Asp Pro Gln Gly
35 40 45
Glu Ile Val Ala Gly His Arg Met Ala Gln Arg Phe Ala Met Cys Ser
50 55 60
Thr Phe Lys Phe Pro Leu Ala Ala Leu Val Phe Glu Arg Ile Asp Ser
65 70 75 80
Gly Thr Glu Arg Gly Asp Arg Lys Leu Ser Tyr Gly Pro Asp Met Ile
85 90 95
Val Glu Trp Ser Pro Ala Thr Glu Arg Phe Leu Ala Ser Gly His Met
100 105 110
Thr Val Leu Glu Ala Ala Gln Ala Ala Val Gln Leu Ser Asp Asn Gly
115 120 125
Ala Thr Asn Leu Leu Leu Arg Glu Ile Gly Gly Pro Ala Ala Met Thr
130 135 140
Gln Tyr Phe Arg Lys Ile Gly Asp Ser Val Ser Arg Leu Asp Arg Lys
145 150 155 160
Glu Pro Glu Met Gly Asp Asn Thr Pro Gly Asp Leu Arg Asp Thr Thr
165 170 175
Thr Pro Ile Ala Met Ala Arg Thr Val Ala Lys Val Leu Tyr Gly Gly
180 185 190
Ala Leu Thr Ser Thr Ser Thr His Thr Ile Glu Arg Trp Leu Ile Gly
195 200 205
Asn Gln Thr Gly Asp Ala Thr Leu Arg Ala Gly Phe Pro Lys Asp Trp
210 215 220
Val Val Gly Glu Lys Thr Gly Thr Cys Ala Asn Gly Gly Arg Asn Asp
225 230 235 240
Ile Gly Phe Phe Lys Ala Gln Glu Arg Asp Tyr Ala Val Ala Val Tyr
245 250 255
Thr Thr Ala Pro Lys Leu Ser Ala Val Glu Arg Asp Glu Leu Val Ala
260 265 270
Ser Val Gly Gln Val Ile Thr Gln Leu Ile Leu Ser Thr Asp Lys
275 280 285
<210> 35
<211> 287
<212> PRT
<213> RESISTANCE GENE
<400> 35
Met Arg Phe Ile His Ala Leu Leu Leu Ala Gly Ile Ala His Ser Ala
1 5 10 15
Tyr Ala Ser Glu Lys Leu Thr Phe Lys Thr Asp Leu Glu Lys Leu Glu
20 25 30
Arg Glu Lys Ala Ala Gln Ile Gly Val Ala Ile Val Asp Pro Gln Gly
35 40 45
Glu Ile Val Ala Gly His Arg Met Ala Gln Arg Phe Ala Met Cys Ser
50 55 60
Thr Phe Lys Phe Pro Leu Ala Ala Leu Val Phe Glu Arg Ile Asp Ser
65 70 75 80
Gly Thr Glu Arg Gly Asp Arg Lys Leu Ser Tyr Gly Pro Asp Met Ile
85 90 95
Val Lys Trp Ser Pro Ala Thr Glu Arg Phe Leu Ala Ser Gly His Met
100 105 110
Thr Val Leu Glu Ala Ala Gln Ala Ala Val Gln Leu Ser Asp Asn Gly
115 120 125
Ala Thr Asn Leu Leu Leu Arg Glu Ile Gly Gly Pro Ala Ala Met Thr
130 135 140
Gln Tyr Phe Arg Lys Ile Gly Asp Ser Val Ser Arg Leu Asp Arg Lys
145 150 155 160
Glu Pro Glu Met Gly Asp Asn Thr Pro Gly Asp Leu Arg Asp Thr Thr
165 170 175
Thr Pro Ile Ala Met Ala Arg Thr Val Ala Lys Val Leu Tyr Gly Gly
180 185 190
Ala Leu Thr Ser Thr Ser Thr His Thr Ile Glu Arg Trp Leu Ile Gly
195 200 205
Asn Gln Thr Gly Asp Ala Thr Leu Arg Ala Gly Phe Pro Lys Asp Trp
210 215 220
Val Val Gly Glu Lys Thr Gly Thr Cys Ala Asn Gly Gly Arg Asn Asp
225 230 235 240
Ile Gly Phe Phe Lys Ala Gln Glu Arg Asp Tyr Ala Val Ala Val Tyr
245 250 255
Thr Thr Ala Pro Lys Leu Ser Ala Val Glu Arg Asp Glu Leu Val Ala
260 265 270
Ser Val Gly Gln Val Ile Thr Gln Leu Ile Leu Ser Thr Asp Lys
275 280 285
<210> 36
<211> 287
<212> PRT
<213> RESISTANCE GENE
<400> 36
Met Arg Phe Ile His Ala Leu Leu Leu Ala Gly Ile Ala His Ser Ala
1 5 10 15
Tyr Ala Ser Glu Lys Leu Thr Phe Lys Thr Asp Leu Glu Lys Leu Glu
20 25 30
Arg Glu Lys Ala Ala Gln Ile Gly Val Ala Ile Val Asp Pro Gln Gly
35 40 45
Glu Ile Val Ala Gly His Arg Met Ala Gln Arg Phe Ala Met Cys Ser
50 55 60
Thr Phe Lys Phe Pro Leu Ala Ala Leu Val Phe Glu Arg Ile Asp Ser
65 70 75 80
Gly Thr Glu Arg Gly Asp Arg Lys Leu Ser Tyr Gly Pro Asp Met Ile
85 90 95
Val Glu Trp Ser Pro Ala Thr Glu Arg Phe Leu Ala Ser Gly His Met
100 105 110
Thr Val Leu Glu Ala Ala Gln Leu Ala Val Gln Leu Ser Asp Asn Gly
115 120 125
Ala Thr Asn Leu Leu Leu Arg Glu Ile Gly Gly Pro Ala Ala Met Thr
130 135 140
Gln Tyr Phe Arg Lys Ile Gly Asp Ser Val Ser Arg Leu Asp Arg Lys
145 150 155 160
Glu Pro Glu Met Gly Asp Asn Thr Pro Gly Asp Leu Arg Asp Thr Thr
165 170 175
Thr Pro Ile Ala Met Ala Arg Thr Val Ala Lys Val Leu Tyr Gly Gly
180 185 190
Ala Leu Thr Ser Thr Ser Thr His Thr Ile Glu Arg Trp Leu Ile Gly
195 200 205
Asn Gln Thr Gly Asp Ala Thr Leu Arg Ala Gly Phe Pro Lys Asp Trp
210 215 220
Val Val Gly Glu Lys Thr Gly Thr Cys Ala Asn Gly Gly Arg Asn Asp
225 230 235 240
Ile Gly Phe Phe Lys Ala Gln Glu Arg Asp Tyr Ala Val Ala Val Tyr
245 250 255
Thr Thr Ala Pro Lys Leu Ser Ala Val Glu Arg Asp Glu Leu Val Ala
260 265 270
Ser Val Gly Gln Val Ile Thr Gln Leu Ile Leu Ser Thr Asp Lys
275 280 285
<210> 37
<211> 287
<212> PRT
<213> RESISTANCE GENE
<400> 37
Met Arg Phe Ile His Ala Leu Leu Leu Ala Gly Ile Ala His Ser Ala
1 5 10 15
Tyr Ala Ser Glu Lys Leu Thr Phe Lys Thr Asp Leu Glu Lys Leu Glu
20 25 30
Arg Glu Lys Ala Ala Gln Ile Gly Val Ala Ile Val Asp Pro Gln Gly
35 40 45
Glu Ile Val Ala Gly His Arg Met Ala Gln Arg Phe Ala Met Cys Ser
50 55 60
Thr Phe Lys Phe Pro Leu Ala Ala Leu Val Phe Glu Arg Ile Asp Ser
65 70 75 80
Gly Thr Glu Arg Gly Asp Arg Lys Leu Ser Tyr Gly Pro Asp Met Ile
85 90 95
Val Glu Trp Ser Pro Ala Thr Glu Arg Phe Leu Ala Ser Gly His Met
100 105 110
Thr Val Leu Glu Ala Ala Gln Ala Ala Val Gln Leu Ser Asp Asn Gly
115 120 125
Ala Thr Asn Leu Leu Leu Arg Glu Ile Gly Gly Pro Ala Ala Met Thr
130 135 140
Gln Tyr Phe Arg Lys Ile Gly Asp Ser Val Ser Arg Leu Asp Arg Lys
145 150 155 160
Glu Pro Glu Met Asn Asp Asn Thr Pro Gly Asp Leu Arg Asp Thr Thr
165 170 175
Thr Pro Ile Ala Met Ala Arg Thr Val Ala Lys Val Leu Tyr Gly Gly
180 185 190
Ala Leu Thr Ser Thr Ser Thr His Thr Ile Glu Arg Trp Leu Ile Gly
195 200 205
Asn Gln Thr Gly Asp Ala Thr Leu Arg Ala Gly Phe Pro Lys Asp Trp
210 215 220
Val Val Gly Glu Lys Thr Gly Thr Cys Ala Asn Gly Gly Arg Asn Asp
225 230 235 240
Ile Gly Phe Phe Lys Ala Gln Glu Arg Asp Tyr Ala Val Ala Val Tyr
245 250 255
Thr Thr Ala Pro Lys Leu Ser Ala Val Glu Arg Asp Glu Leu Val Ala
260 265 270
Ser Val Gly Gln Val Ile Thr Gln Leu Ile Leu Ser Thr Asp Lys
275 280 285
<210> 38
<211> 287
<212> PRT
<213> RESISTANCE GENE
<400> 38
Met Arg Phe Ile His Ala Leu Leu Leu Ala Gly Ile Ala His Ser Ala
1 5 10 15
Tyr Ala Ser Glu Lys Leu Thr Phe Lys Thr Asp Leu Glu Lys Leu Glu
20 25 30
Arg Glu Lys Ala Ala Gln Ile Gly Val Ala Ile Val Asp Pro Gln Gly
35 40 45
Glu Ile Val Ala Gly His Arg Met Ala Gln Arg Phe Ala Met Cys Ser
50 55 60
Thr Phe Lys Phe Pro Leu Ala Ala Leu Val Phe Glu Arg Ile Asp Ser
65 70 75 80
Gly Thr Glu Arg Gly Asp Arg Lys Leu Ser Tyr Gly Pro Asp Met Ile
85 90 95
Val Glu Trp Ser Pro Ala Thr Glu Arg Phe Leu Ala Ser Gly His Met
100 105 110
Thr Val Leu Glu Ala Ala Gln Ala Ala Val Gln Leu Ser Asp Asn Gly
115 120 125
Ala Thr Asn Leu Leu Leu Arg Glu Ile Gly Gly Pro Ala Ala Met Thr
130 135 140
Gln Tyr Phe Arg Lys Ile Gly Asp Ser Val Ser Arg Leu Asp Arg Lys
145 150 155 160
Glu Pro Glu Met Ser Asp Asn Thr Pro Gly Asp Leu Arg Asp Thr Thr
165 170 175
Thr Pro Ile Ala Met Ala Arg Thr Val Ala Lys Val Leu Tyr Gly Gly
180 185 190
Ala Leu Thr Ser Thr Ser Thr His Thr Ile Glu Arg Trp Leu Ile Gly
195 200 205
Asn Gln Thr Gly Asp Ala Thr Leu Arg Ala Gly Phe Pro Lys Asp Trp
210 215 220
Val Val Gly Glu Lys Thr Gly Thr Cys Ala Asn Gly Gly Arg Asn Asp
225 230 235 240
Ile Gly Phe Phe Lys Ala Gln Glu Arg Asp Tyr Ala Val Ala Val Tyr
245 250 255
Thr Thr Ala Pro Lys Leu Ser Ala Val Glu Arg Asp Glu Leu Val Ala
260 265 270
Ser Val Gly Gln Val Ile Thr Gln Leu Ile Leu Ser Thr Asp Lys
275 280 285
<210> 39
<211> 287
<212> PRT
<213> RESISTANCE GENE
<400> 39
Met Arg Phe Ile His Ala Leu Leu Leu Ala Gly Ile Ala His Ser Ala
1 5 10 15
Tyr Ala Ser Glu Lys Leu Thr Phe Lys Thr Asp Leu Glu Lys Leu Glu
20 25 30
Arg Glu Lys Ala Ala Gln Ile Gly Val Ala Ile Val Asp Pro Gln Gly
35 40 45
Glu Ile Val Ala Gly His Arg Met Ala Gln Arg Phe Ala Met Cys Ser
50 55 60
Thr Phe Lys Phe Pro Leu Ala Ala Leu Val Phe Glu Arg Ile Asp Ser
65 70 75 80
Gly Thr Glu Arg Gly Asp Arg Lys Leu Ser Tyr Gly Pro Asp Met Ile
85 90 95
Val Lys Trp Ser Pro Ala Thr Glu Arg Phe Leu Ala Ser Gly His Met
100 105 110
Thr Val Leu Glu Ala Ala Gln Ala Ala Val Gln Leu Ser Asp Asn Gly
115 120 125
Ala Thr Asn Leu Leu Leu Arg Glu Ile Gly Gly Pro Ala Ala Met Thr
130 135 140
Gln Tyr Phe Arg Lys Ile Gly Asp Ser Val Ser Arg Leu Asp Arg Lys
145 150 155 160
Glu Pro Glu Met Ser Asp Asn Thr Pro Gly Asp Leu Arg Asp Thr Thr
165 170 175
Thr Pro Ile Ala Met Ala Arg Thr Val Ala Lys Val Leu Tyr Gly Gly
180 185 190
Ala Leu Thr Ser Thr Ser Thr His Thr Ile Glu Arg Trp Leu Ile Gly
195 200 205
Asn Gln Thr Gly Asp Ala Thr Leu Arg Ala Gly Phe Pro Lys Asp Trp
210 215 220
Val Val Gly Glu Lys Thr Gly Thr Cys Ala Asn Gly Gly Arg Asn Asp
225 230 235 240
Ile Gly Phe Phe Lys Ala Gln Glu Arg Asp Tyr Ala Val Ala Val Tyr
245 250 255
Thr Thr Ala Pro Lys Leu Ser Ala Val Glu Arg Asp Glu Leu Val Ala
260 265 270
Ser Val Gly Gln Val Ile Thr Gln Leu Ile Leu Ser Thr Asp Lys
275 280 285
<210> 40
<211> 287
<212> PRT
<213> RESISTANCE GENE
<400> 40
Met Arg Phe Ile His Ala Leu Leu Leu Ala Gly Ile Ala His Ser Ala
1 5 10 15
Tyr Ala Ser Glu Lys Leu Thr Phe Lys Thr Asp Leu Glu Lys Leu Glu
20 25 30
Arg Glu Lys Ala Ala Gln Ile Gly Val Ala Ile Val Asp Pro Gln Gly
35 40 45
Glu Ile Val Ala Gly His Arg Met Ala Gln Arg Phe Ala Met Cys Ser
50 55 60
Thr Phe Lys Phe Pro Leu Ala Ala Leu Val Phe Glu Arg Ile Asp Ser
65 70 75 80
Gly Thr Glu Arg Gly Asp Arg Lys Leu Ser Tyr Gly Pro Asp Met Ile
85 90 95
Val Glu Trp Ser Pro Ala Thr Glu Arg Phe Leu Ala Ser Gly His Met
100 105 110
Thr Val Leu Glu Ala Ala Gln Ala Ala Val Gln Leu Ser Asp Asn Gly
115 120 125
Ala Thr Asn Leu Leu Leu Arg Glu Ile Gly Gly Pro Ala Ala Met Thr
130 135 140
Gln Tyr Phe Arg Lys Ile Gly Asp Ser Val Ser Arg Leu Asp Arg Lys
145 150 155 160
Glu Pro Glu Met Gly Asp Asn Thr Pro Gly Asp Leu Arg Asp Thr Thr
165 170 175
Thr Pro Ile Ala Met Ala Arg Thr Val Ala Lys Val Leu Tyr Gly Gly
180 185 190
Ala Leu Thr Ser Thr Ser Thr His Thr Ile Glu Arg Trp Leu Ile Gly
195 200 205
Asn Gln Thr Gly Asp Ala Thr Leu Arg Ala Gly Phe Pro Lys Asp Trp
210 215 220
Val Val Gly Glu Lys Thr Gly Thr Cys Ala Asn Gly Ser Arg Asn Asp
225 230 235 240
Ile Gly Phe Phe Lys Ala Gln Glu Arg Asp Tyr Ala Val Ala Val Tyr
245 250 255
Thr Thr Ala Pro Lys Leu Ser Ala Val Glu Arg Asp Glu Leu Val Ala
260 265 270
Ser Val Gly Gln Val Ile Thr Gln Leu Ile Leu Ser Thr Asp Lys
275 280 285
<210> 41
<211> 287
<212> PRT
<213> RESISTANCE GENE
<400> 41
Met Arg Phe Ile His Ala Leu Leu Leu Ala Gly Ile Ala His Ser Ala
1 5 10 15
Tyr Ala Ser Glu Lys Leu Thr Phe Lys Thr Asp Leu Glu Lys Leu Glu
20 25 30
Arg Glu Lys Ala Ala Gln Ile Gly Val Ala Ile Val Asp Pro Gln Gly
35 40 45
Glu Ile Val Ala Gly His Arg Met Ala Gln Arg Phe Ala Met Cys Ser
50 55 60
Thr Phe Lys Phe Pro Leu Ala Ala Leu Val Phe Glu Arg Ile Asp Ser
65 70 75 80
Gly Thr Glu Arg Gly Asp Arg Lys Leu Ser Tyr Gly Pro Asp Met Ile
85 90 95
Val Glu Trp Ser Pro Ala Thr Glu Arg Phe Leu Ala Ser Gly His Met
100 105 110
Thr Val Leu Glu Ala Ala Gln Ala Ala Val Gln Leu Ser Asp Asn Gly
115 120 125
Ala Thr Asn Leu Leu Leu Arg Glu Ile Gly Gly Pro Ala Ala Met Thr
130 135 140
Gln Tyr Phe Arg Lys Ile Gly Asp Ser Val Ser Arg Leu Asp Arg Lys
145 150 155 160
Glu Pro Glu Met Gly Asp Asn Thr Pro Gly Asp Leu Arg Asp Thr Thr
165 170 175
Thr Pro Ile Ala Met Ala Arg Thr Val Ala Lys Val Leu Tyr Gly Gly
180 185 190
Ala Leu Thr Ser Thr Ser Thr His Thr Ile Glu Arg Trp Leu Ile Gly
195 200 205
Asn Gln Thr Gly Asp Ala Thr Leu Arg Ala Gly Phe Pro Lys Asp Trp
210 215 220
Val Val Gly Glu Lys Thr Gly Thr Cys Ala Asn Gly Ala Arg Asn Asp
225 230 235 240
Ile Gly Phe Phe Lys Ala Gln Glu Arg Asp Tyr Ala Val Ala Val Tyr
245 250 255
Thr Thr Ala Pro Lys Leu Ser Ala Val Glu Arg Asp Glu Leu Val Ala
260 265 270
Ser Val Gly Gln Val Ile Thr Gln Leu Ile Leu Ser Thr Asp Lys
275 280 285
<210> 42
<211> 287
<212> PRT
<213> RESISTANCE GENE
<400> 42
Met Arg Phe Ile His Ala Leu Leu Leu Ala Gly Thr Ala His Ser Ala
1 5 10 15
Tyr Ala Ser Glu Lys Leu Thr Phe Lys Thr Asp Leu Glu Lys Leu Glu
20 25 30
Arg Glu Lys Ala Ala Gln Ile Gly Val Ala Ile Val Asp Pro Gln Gly
35 40 45
Glu Ile Val Ala Gly His Arg Thr Ala Gln Arg Phe Ala Met Cys Ser
50 55 60
Thr Phe Lys Phe Pro Leu Ala Ala Leu Val Phe Glu Arg Ile Asp Ser
65 70 75 80
Gly Thr Glu Arg Gly Asp Arg Lys Leu Ser Tyr Gly Pro Asp Met Ile
85 90 95
Val Glu Trp Ser Pro Ala Thr Glu Arg Phe Leu Ala Ser Gly His Met
100 105 110
Thr Val Leu Glu Ala Ala Gln Ala Ala Val Gln Leu Cys Asp Asn Gly
115 120 125
Ala Thr Asn Leu Leu Leu Arg Glu Ile Gly Gly Pro Ala Ala Met Thr
130 135 140
Gln Tyr Phe Arg Lys Ile Gly Asp Ser Val Ser Arg Leu Asp Arg Lys
145 150 155 160
Glu Pro Glu Met Gly Asp Asn Thr Pro Gly Asp Leu Arg Asp Thr Thr
165 170 175
Thr Pro Ile Ala Met Ala Arg Thr Val Ala Lys Val Leu Tyr Gly Gly
180 185 190
Ala Leu Thr Ser Thr Ser Thr His Thr Ile Glu Arg Trp Leu Ile Gly
195 200 205
Asn Gln Thr Gly Asp Ala Thr Leu Arg Ala Gly Phe Pro Lys Asp Trp
210 215 220
Val Val Gly Glu Lys Thr Gly Thr Cys Ala Asn Gly Gly Arg Asn Asp
225 230 235 240
Ile Gly Phe Phe Lys Ala Gln Glu Arg Asp Tyr Ala Val Ala Val Tyr
245 250 255
Thr Thr Ala Pro Lys Leu Ser Ala Val Glu Arg Asp Glu Leu Val Ala
260 265 270
Ser Val Gly Gln Val Ile Thr Gln Leu Ile Leu Ser Thr Asp Lys
275 280 285
<210> 43
<211> 287
<212> PRT
<213> RESISTANCE GENE
<400> 43
Met Arg Phe Ile His Ala Leu Leu Leu Ala Gly Ile Ala His Ser Ala
1 5 10 15
Tyr Ala Ser Glu Lys Leu Thr Phe Lys Thr Asp Leu Glu Lys Leu Glu
20 25 30
Arg Glu Lys Ala Ala Gln Ile Gly Val Ala Ile Val Asp Pro Gln Gly
35 40 45
Glu Ile Val Ala Gly His Arg Met Ala Gln Arg Phe Ala Met Cys Ser
50 55 60
Thr Phe Lys Phe Pro Leu Ala Ala Leu Val Phe Glu Arg Ile Asp Ser
65 70 75 80
Gly Thr Glu Arg Gly Asp Arg Lys Leu Ser Tyr Gly Pro Asp Met Ile
85 90 95
Val Lys Trp Ser Pro Ala Thr Glu Arg Phe Leu Ala Ser Gly His Met
100 105 110
Thr Val Leu Glu Ala Ala Gln Ala Ala Val Gln Leu Ser Asp Asn Gly
115 120 125
Ala Thr Asn Leu Leu Leu Arg Glu Ile Gly Gly Pro Ala Ala Met Thr
130 135 140
Gln Tyr Phe Arg Lys Ile Gly Asp Ser Val Ser Arg Leu Asp Arg Lys
145 150 155 160
Glu Pro Glu Met Asn Asp Asn Thr Pro Gly Asp Leu Arg Asp Thr Thr
165 170 175
Thr Pro Ile Ala Met Ala Arg Thr Val Ala Lys Val Leu Tyr Gly Gly
180 185 190
Ala Leu Thr Ser Thr Ser Thr His Thr Ile Glu Arg Trp Leu Ile Gly
195 200 205
Asn Gln Thr Gly Asp Ala Thr Leu Arg Ala Gly Phe Pro Lys Asp Trp
210 215 220
Val Val Gly Glu Lys Thr Gly Thr Cys Ala Asn Gly Gly Arg Asn Asp
225 230 235 240
Ile Gly Phe Phe Lys Ala Gln Glu Arg Asp Tyr Ala Val Ala Val Tyr
245 250 255
Thr Thr Ala Pro Lys Leu Ser Ala Val Glu Arg Asp Glu Leu Val Ala
260 265 270
Ser Val Gly Gln Val Ile Thr Gln Leu Ile Leu Ser Thr Asp Lys
275 280 285
<210> 44
<211> 287
<212> PRT
<213> RESISTANCE GENE
<400> 44
Met Arg Phe Ile His Ala Leu Leu Leu Ala Gly Ile Ala His Ser Ala
1 5 10 15
Tyr Ala Ser Glu Lys Leu Thr Phe Lys Thr Asp Leu Glu Lys Leu Glu
20 25 30
Arg Glu Lys Ala Ala Gln Ile Gly Val Ala Ile Val Asp Pro Gln Gly
35 40 45
Glu Ile Val Ala Gly His Arg Met Ala Gln Arg Phe Ala Met Cys Ser
50 55 60
Thr Phe Lys Phe Pro Leu Ala Ala Leu Val Phe Glu Arg Ile Asp Ser
65 70 75 80
Gly Thr Glu Arg Gly Asp Arg Lys Leu Ser Tyr Gly Pro Asp Met Ile
85 90 95
Val Glu Trp Ser Pro Ala Thr Glu Arg Phe Leu Ala Ser Gly His Met
100 105 110
Thr Val Leu Glu Ala Ala Gln Ala Ala Val Gln Leu Ser Asp Asn Gly
115 120 125
Ala Thr Asn Leu Leu Leu Arg Glu Ile Gly Gly Pro Ala Ala Met Thr
130 135 140
Gln Tyr Phe Arg Lys Ile Gly Asp Ser Val Ser Arg Leu Asp Arg Lys
145 150 155 160
Glu Ser Glu Met Ser Asp Asn Thr Pro Gly Asp Leu Arg Asp Thr Thr
165 170 175
Thr Pro Ile Ala Met Ala Arg Thr Val Ala Lys Val Leu Tyr Gly Gly
180 185 190
Ala Leu Thr Ser Thr Ser Thr His Thr Ile Glu Arg Trp Leu Ile Gly
195 200 205
Asn Gln Thr Gly Asp Ala Thr Leu Arg Ala Gly Phe Pro Lys Asp Trp
210 215 220
Val Val Gly Glu Lys Thr Gly Thr Cys Ala Asn Gly Gly Arg Asn Asp
225 230 235 240
Ile Gly Phe Phe Lys Ala Gln Glu Arg Asp Tyr Ala Val Ala Val Tyr
245 250 255
Thr Thr Ala Pro Lys Leu Ser Ala Val Glu Arg Asp Glu Leu Val Ala
260 265 270
Ser Val Gly Gln Val Ile Thr Gln Leu Ile Leu Ser Thr Asp Lys
275 280 285
<210> 45
<211> 287
<212> PRT
<213> RESISTANCE GENE
<400> 45
Met Arg Phe Ile His Ala Leu Leu Leu Ala Gly Ile Ala His Ser Ala
1 5 10 15
Tyr Ala Ser Glu Lys Leu Thr Phe Lys Thr Asp Leu Glu Lys Leu Glu
20 25 30
Arg Glu Lys Ala Ala Gln Ile Gly Val Ala Ile Val Asp Pro Gln Gly
35 40 45
Glu Ile Val Ala Gly His Arg Met Ala Gln Arg Phe Ala Met Cys Ser
50 55 60
Thr Phe Lys Phe Pro Leu Ala Ala Leu Val Phe Glu Arg Ile Asp Ser
65 70 75 80
Gly Thr Glu Arg Gly Asp Arg Lys Leu Ser Tyr Gly Pro Asp Met Ile
85 90 95
Val Glu Trp Ser Pro Ala Thr Glu Arg Phe Leu Ala Ser Gly His Met
100 105 110
Thr Val Leu Glu Ala Ala Gln Ala Ala Val Gln Leu Ser Asp Asn Gly
115 120 125
Ala Thr Asn Leu Leu Leu Arg Glu Ile Gly Gly Pro Ala Ala Met Thr
130 135 140
Gln Tyr Phe Arg Lys Ile Gly Asp Ser Val Ser Arg Leu Asp Arg Lys
145 150 155 160
Glu Pro Glu Met Ser Asp Asn Thr Pro Gly Asp Leu Arg Asp Thr Thr
165 170 175
Thr Pro Ile Ala Met Ala Arg Thr Val Ala Lys Val Leu Tyr Gly Gly
180 185 190
Ala Leu Thr Ser Thr Ser Thr His Thr Ile Glu Arg Trp Leu Ile Gly
195 200 205
Asn Gln Thr Gly Asp Ala Thr Leu Arg Ala Gly Phe Pro Lys Asp Trp
210 215 220
Val Val Gly Glu Lys Thr Gly Thr Cys Ala Asn Gly Ala Arg Asn Asp
225 230 235 240
Ile Gly Phe Phe Lys Ala Gln Glu Arg Asp Tyr Ala Val Ala Val Tyr
245 250 255
Thr Thr Ala Pro Lys Leu Ser Ala Val Glu Arg Asp Glu Leu Val Ala
260 265 270
Ser Val Gly Gln Val Ile Thr Gln Leu Ile Leu Ser Thr Asp Lys
275 280 285
<210> 46
<211> 287
<212> PRT
<213> RESISTANCE GENE
<400> 46
Met Arg Phe Ile His Ala Leu Leu Leu Ala Gly Ile Ala His Ser Ala
1 5 10 15
Tyr Ala Ser Glu Lys Leu Thr Phe Lys Thr Asp Leu Glu Lys Leu Glu
20 25 30
Arg Glu Lys Ala Ala Glu Ile Gly Val Ala Ile Val Asp Pro Gln Gly
35 40 45
Glu Ile Val Ala Gly His Arg Met Ala Gln Arg Phe Ala Met Cys Ser
50 55 60
Thr Phe Lys Phe Pro Leu Ala Ala Leu Val Phe Glu Arg Ile Asp Ser
65 70 75 80
Gly Thr Glu Arg Gly Asp Arg Lys Leu Ser Tyr Gly Pro Asp Met Ile
85 90 95
Val Glu Trp Ser Pro Ala Thr Glu Arg Phe Leu Ala Ser Gly His Met
100 105 110
Thr Val Leu Glu Ala Ala Gln Ala Ala Val Gln Leu Ser Asp Asn Gly
115 120 125
Ala Thr Asn Leu Leu Leu Arg Glu Ile Gly Gly Pro Ala Ala Met Thr
130 135 140
Gln Tyr Phe Arg Lys Ile Gly Asp Ser Val Ser Arg Leu Asp Arg Lys
145 150 155 160
Glu Pro Glu Met Ser Asp Asn Thr Pro Gly Asp Leu Arg Asp Thr Thr
165 170 175
Thr Pro Ile Ala Met Ala Arg Thr Val Ala Lys Val Leu Tyr Gly Gly
180 185 190
Ala Leu Thr Ser Thr Ser Thr His Thr Ile Glu Arg Trp Leu Ile Gly
195 200 205
Asn Gln Thr Gly Asp Ala Thr Leu Arg Ala Gly Phe Pro Lys Asp Trp
210 215 220
Val Val Gly Glu Lys Thr Gly Thr Cys Ala Asn Gly Gly Arg Asn Asp
225 230 235 240
Ile Gly Phe Phe Lys Ala Gln Glu Arg Asp Tyr Ala Val Ala Val Tyr
245 250 255
Thr Thr Ala Pro Lys Leu Ser Ala Val Glu Arg Asp Glu Leu Val Ala
260 265 270
Ser Val Gly Gln Val Ile Thr Gln Leu Ile Leu Ser Thr Asp Lys
275 280 285
<210> 47
<211> 287
<212> PRT
<213> RESISTANCE GENE
<400> 47
Met Arg Phe Ile His Ala Leu Leu Leu Ala Gly Ile Ala His Ser Ala
1 5 10 15
Tyr Ala Ser Glu Lys Leu Thr Phe Lys Thr Asp Leu Glu Lys Leu Glu
20 25 30
Arg Glu Lys Ala Ala Gln Ile Gly Val Ala Ile Val Asp Pro Gln Gly
35 40 45
Glu Ile Val Ala Gly His Arg Met Ala Gln Arg Phe Ala Met Cys Ser
50 55 60
Thr Phe Lys Phe Pro Leu Ala Ala Leu Val Phe Glu Arg Ile Asp Ser
65 70 75 80
Gly Thr Glu Arg Gly Asp Arg Lys Leu Ser Tyr Gly Pro Asp Met Ile
85 90 95
Val Lys Trp Ser Pro Ala Thr Glu Arg Phe Leu Ala Ser Gly His Met
100 105 110
Thr Val Leu Glu Ala Ala Gln Ala Ala Val Gln Leu Ser Asp Asn Gly
115 120 125
Ala Thr Asn Leu Leu Leu Arg Glu Ile Gly Gly Pro Ala Ala Met Thr
130 135 140
Gln Tyr Phe Arg Lys Ile Gly Asp Ser Val Ser Arg Leu Asp Arg Lys
145 150 155 160
Glu Pro Glu Met Gly Asp Asn Thr Pro Gly Asp Leu Arg Asp Thr Thr
165 170 175
Thr Pro Ile Ala Met Ala Arg Thr Val Ala Lys Val Leu Tyr Gly Gly
180 185 190
Ala Leu Thr Ser Thr Ser Thr His Thr Ile Glu Arg Trp Leu Ile Gly
195 200 205
Asn Gln Thr Gly Asp Ala Thr Leu Arg Ala Gly Phe Pro Lys Asp Trp
210 215 220
Val Val Gly Glu Lys Thr Gly Thr Cys Ala Asn Gly Ala Arg Asn Asp
225 230 235 240
Ile Gly Phe Phe Lys Ala Gln Glu Arg Asp Tyr Ala Val Ala Val Tyr
245 250 255
Thr Thr Ala Pro Lys Leu Ser Ala Val Glu Arg Asp Glu Leu Val Ala
260 265 270
Ser Val Gly Gln Val Ile Thr Gln Leu Ile Leu Ser Thr Asp Lys
275 280 285
<210> 48
<211> 287
<212> PRT
<213> RESISTANCE GENE
<400> 48
Met Arg Phe Ile His Ala Leu Leu Leu Ala Gly Ile Ala His Ser Ala
1 5 10 15
Tyr Ala Ser Glu Lys Leu Thr Phe Lys Thr Asp Leu Glu Lys Leu Glu
20 25 30
Arg Glu Lys Ala Ala Gln Ile Gly Val Ala Ile Val Asp Pro Gln Gly
35 40 45
Glu Ile Val Ala Gly His Arg Thr Ala Gln Arg Phe Ala Met Cys Ser
50 55 60
Thr Phe Lys Phe Pro Leu Ala Ala Leu Val Phe Glu Arg Ile Asp Ser
65 70 75 80
Gly Thr Glu Arg Gly Asp Arg Lys Leu Ser Tyr Gly Pro Asp Met Ile
85 90 95
Val Lys Trp Ser Pro Ala Thr Glu Arg Phe Leu Ala Ser Gly His Met
100 105 110
Thr Val Leu Glu Ala Ala Gln Ala Ala Val Gln Leu Ser Asp Asn Gly
115 120 125
Ala Thr Asn Leu Leu Leu Arg Glu Ile Gly Gly Pro Ala Ala Met Thr
130 135 140
Gln Tyr Phe Arg Lys Ile Gly Asp Ser Val Ser Arg Leu Asp Arg Lys
145 150 155 160
Glu Pro Glu Met Gly Asp Asn Thr Pro Gly Asp Leu Arg Asp Thr Thr
165 170 175
Thr Pro Ile Ala Met Ala Arg Thr Val Ala Lys Val Leu Tyr Gly Gly
180 185 190
Ala Leu Thr Ser Thr Ser Thr His Thr Ile Glu Arg Trp Leu Ile Gly
195 200 205
Asn Gln Thr Gly Asp Ala Thr Leu Arg Ala Gly Phe Pro Lys Asp Trp
210 215 220
Val Val Gly Glu Lys Thr Gly Thr Cys Ala Asn Gly Gly Arg Asn Asp
225 230 235 240
Ile Gly Phe Phe Lys Ala Gln Glu Arg Asp Tyr Ala Val Ala Val Tyr
245 250 255
Thr Thr Ala Pro Lys Leu Ser Ala Val Glu Arg Asp Glu Leu Val Ala
260 265 270
Ser Val Gly Gln Val Ile Thr Gln Leu Ile Leu Ser Thr Asp Lys
275 280 285
<210> 49
<211> 287
<212> PRT
<213> RESISTANCE GENE
<400> 49
Met Arg Phe Ile His Ala Leu Leu Leu Ala Gly Ile Ala His Ser Ala
1 5 10 15
Tyr Ala Ser Glu Lys Leu Thr Phe Lys Thr Asp Leu Glu Lys Leu Glu
20 25 30
Arg Glu Lys Ala Ala Gln Ile Gly Val Ala Ile Val Asp Pro Gln Gly
35 40 45
Glu Ile Val Ala Gly His Arg Thr Ala Gln Arg Phe Ala Met Cys Ser
50 55 60
Thr Phe Lys Phe Pro Leu Ala Ala Leu Val Phe Glu Arg Ile Asp Ser
65 70 75 80
Gly Thr Glu Arg Gly Asp Arg Lys Leu Ser Tyr Gly Pro Asp Met Ile
85 90 95
Val Lys Trp Ser Pro Ala Thr Glu Arg Phe Leu Ala Ser Gly His Met
100 105 110
Thr Val Leu Glu Ala Ala Gln Ala Ala Val Gln Leu Ser Asp Asn Gly
115 120 125
Ala Thr Asn Leu Leu Leu Arg Glu Ile Gly Gly Pro Ala Ala Met Thr
130 135 140
Gln Tyr Phe Arg Lys Ile Gly Asp Ser Val Ser Arg Leu Asp Arg Lys
145 150 155 160
Glu Pro Glu Met Ser Asp Asn Thr Pro Gly Asp Leu Arg Asp Thr Thr
165 170 175
Thr Pro Ile Ala Met Ala Arg Thr Val Ala Lys Val Leu Tyr Gly Gly
180 185 190
Ala Leu Thr Ser Thr Ser Thr His Thr Ile Glu Arg Trp Leu Ile Gly
195 200 205
Asn Gln Thr Gly Asp Ala Thr Leu Arg Ala Gly Phe Pro Lys Asp Trp
210 215 220
Val Val Gly Glu Lys Thr Gly Thr Cys Ala Asn Gly Gly Arg Asn Asp
225 230 235 240
Ile Gly Phe Phe Lys Ala Gln Glu Arg Asp Tyr Ala Val Ala Val Tyr
245 250 255
Thr Thr Ala Pro Lys Leu Ser Ala Val Glu Arg Asp Glu Leu Val Ala
260 265 270
Ser Val Gly Gln Val Ile Thr Gln Leu Ile Leu Ser Thr Asp Lys
275 280 285
<210> 50
<211> 287
<212> PRT
<213> RESISTANCE GENE
<400> 50
Met Arg Phe Ile His Ala Leu Leu Leu Ala Gly Ile Ala His Ser Ala
1 5 10 15
Tyr Ala Ser Glu Lys Leu Thr Phe Lys Thr Asp Leu Glu Lys Leu Glu
20 25 30
Arg Glu Lys Ala Ala Gln Ile Gly Val Ala Ile Val Asp Pro Gln Gly
35 40 45
Glu Ile Val Ala Gly His Arg Met Ala Gln Arg Phe Ala Met Cys Ser
50 55 60
Thr Phe Lys Phe Pro Leu Ala Ala Leu Val Phe Glu Arg Ile Asp Ser
65 70 75 80
Gly Thr Glu Arg Gly Asp Arg Lys Leu Ser Tyr Gly Pro Asp Met Ile
85 90 95
Val Glu Trp Ser Pro Ala Thr Glu Arg Phe Leu Ala Ser Gly His Met
100 105 110
Thr Val Leu Glu Ala Ala Gln Ala Ala Val Gln Leu Ser Asp Asn Gly
115 120 125
Ala Thr Asn Leu Leu Leu Arg Glu Ile Gly Gly Pro Ala Ala Met Thr
130 135 140
Gln Tyr Phe Arg Lys Ile Gly Asp Ser Val Ser Arg Leu Asp Arg Lys
145 150 155 160
Glu Pro Glu Met Gly Asp Asn Thr Pro Gly Asp Leu Arg Asp Thr Thr
165 170 175
Thr Pro Ile Ala Met Ala Arg Thr Val Ala Lys Val Leu Tyr Gly Gly
180 185 190
Ala Leu Thr Ser Thr Ser Thr His Thr Ile Glu Arg Trp Leu Ile Gly
195 200 205
Asn Gln Thr Gly Asp Ala Thr Leu Arg Ala Gly Phe Pro Lys Asp Trp
210 215 220
Val Val Gly Glu Lys Thr Gly Ala Cys Ala Asn Gly Ala Arg Asn Asp
225 230 235 240
Ile Gly Phe Phe Lys Ala Gln Glu Arg Asp Tyr Ala Val Ala Val Tyr
245 250 255
Thr Thr Ala Pro Lys Leu Ser Ala Val Glu Arg Asp Glu Leu Val Ala
260 265 270
Ser Val Gly Gln Val Ile Thr Gln Leu Ile Leu Ser Thr Asp Lys
275 280 285
<210> 51
<211> 20
<212> PRT
<213> RESISTANCE GENE
<400> 51
Ala Ala Glu Ile Gly Val Ala Ile Val Asp Pro Gln Gly Glu Ile Val
1 5 10 15
Ala Gly His Arg
20
<210> 52
<211> 20
<212> PRT
<213> RESISTANCE GENE
<400> 52
Ala Ala Gln Ile Gly Val Ala Ile Val Asp Pro Gln Gly Glu Ile Val
1 5 10 15
Ala Gly His Arg
20
<210> 53
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 53
Ala Gly Phe Pro Lys
1 5
<210> 54
<211> 10
<212> PRT
<213> RESISTANCE GENE
<400> 54
Asp Thr Thr Thr Pro Ile Ala Met Ala Arg
1 5 10
<210> 55
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 55
Asp Trp Val Val Gly Glu Lys
1 5
<210> 56
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 56
Asp Tyr Ala Val Ala Val Tyr Thr Thr Ala Pro Lys
1 5 10
<210> 57
<211> 13
<212> PRT
<213> RESISTANCE GENE
<400> 57
Glu Ile Gly Gly Pro Ala Ala Met Thr Gln Tyr Phe Arg
1 5 10
<210> 58
<211> 13
<212> PRT
<213> RESISTANCE GENE
<400> 58
Glu Pro Glu Met Gly Asp Asn Thr Pro Gly Asp Leu Arg
1 5 10
<210> 59
<211> 13
<212> PRT
<213> RESISTANCE GENE
<400> 59
Glu Pro Glu Met Asn Asp Asn Thr Pro Gly Asp Leu Arg
1 5 10
<210> 60
<211> 13
<212> PRT
<213> RESISTANCE GENE
<400> 60
Glu Pro Glu Met Ser Asp Asn Thr Pro Gly Asp Leu Arg
1 5 10
<210> 61
<211> 13
<212> PRT
<213> RESISTANCE GENE
<400> 61
Glu Ser Glu Met Ser Asp Asn Thr Pro Gly Asp Leu Arg
1 5 10
<210> 62
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 62
Phe Ala Met Cys Ser Thr Phe Lys
1 5
<210> 63
<211> 19
<212> PRT
<213> RESISTANCE GENE
<400> 63
Phe Ile His Ala Leu Leu Leu Ala Gly Ile Ala His Ser Ala Tyr Ala
1 5 10 15
Ser Glu Lys
<210> 64
<211> 19
<212> PRT
<213> RESISTANCE GENE
<400> 64
Phe Ile His Ala Leu Leu Leu Ala Gly Thr Ala His Ser Ala Tyr Ala
1 5 10 15
Ser Glu Lys
<210> 65
<211> 10
<212> PRT
<213> RESISTANCE GENE
<400> 65
Phe Pro Leu Ala Ala Leu Val Phe Glu Arg
1 5 10
<210> 66
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 66
Ile Asp Ser Gly Thr Glu Arg
1 5
<210> 67
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 67
Ile Gly Asp Ser Val Ser Arg
1 5
<210> 68
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 68
Leu Ser Ala Val Glu Arg
1 5
<210> 69
<211> 17
<212> PRT
<213> RESISTANCE GENE
<400> 69
Leu Ser Tyr Gly Pro Asp Met Ile Val Glu Trp Ser Pro Ala Thr Glu
1 5 10 15
Arg
<210> 70
<211> 10
<212> PRT
<213> RESISTANCE GENE
<400> 70
Leu Ser Tyr Gly Pro Asp Met Ile Val Lys
1 5 10
<210> 71
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 71
Asn Asp Ile Gly Phe Phe Lys
1 5
<210> 72
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 72
Thr Asp Leu Glu Lys
1 5
<210> 73
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 73
Thr Gly Ala Cys Ala Asn Gly Ala Arg
1 5
<210> 74
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 74
Thr Gly Thr Cys Ala Asn Gly Ala Arg
1 5
<210> 75
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 75
Thr Gly Thr Cys Ala Asn Gly Gly Arg
1 5
<210> 76
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 76
Thr Gly Thr Cys Ala Asn Gly Ser Arg
1 5
<210> 77
<211> 17
<212> PRT
<213> RESISTANCE GENE
<400> 77
Val Leu Tyr Gly Gly Ala Leu Thr Ser Thr Ser Thr His Thr Ile Glu
1 5 10 15
Arg
<210> 78
<211> 13
<212> PRT
<213> RESISTANCE GENE
<400> 78
Trp Leu Ile Gly Asn Gln Thr Gly Asp Ala Thr Leu Arg
1 5 10
<210> 79
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 79
Trp Ser Pro Ala Thr Glu Arg
1 5
<210> 80
<211> 246
<212> PRT
<213> RESISTANCE GENE
<400> 80
Met Ser Lys Leu Ser Val Phe Phe Ile Phe Leu Phe Cys Ser Ile Ala
1 5 10 15
Thr Ala Ala Glu Ser Leu Pro Asp Leu Lys Ile Glu Lys Leu Asp Glu
20 25 30
Gly Val Tyr Val His Thr Ser Phe Glu Glu Val Asn Gly Trp Gly Val
35 40 45
Val Pro Lys His Gly Leu Val Val Leu Val Asn Ala Glu Ala Tyr Leu
50 55 60
Ile Asp Thr Pro Phe Thr Ala Lys Asp Thr Glu Lys Leu Val Thr Trp
65 70 75 80
Phe Val Glu Arg Gly Tyr Lys Ile Lys Gly Ser Ile Ser Ser His Phe
85 90 95
His Ser Asp Ser Thr Gly Gly Ile Glu Trp Leu Asn Ser Arg Ser Ile
100 105 110
Pro Thr Tyr Ala Ser Glu Leu Thr Asn Glu Leu Leu Lys Lys Asp Gly
115 120 125
Lys Val Gln Ala Thr Asn Ser Phe Ser Gly Val Asn Tyr Trp Leu Val
130 135 140
Lys Asn Lys Ile Glu Val Phe Tyr Pro Gly Pro Gly His Thr Pro Asp
145 150 155 160
Asn Val Val Val Trp Leu Pro Glu Arg Lys Ile Leu Phe Gly Gly Cys
165 170 175
Phe Ile Lys Pro Tyr Gly Leu Gly Asn Leu Gly Asp Ala Asn Ile Glu
180 185 190
Ala Trp Pro Lys Ser Ala Lys Leu Leu Lys Ser Lys Tyr Gly Lys Ala
195 200 205
Lys Leu Val Val Pro Ser His Ser Glu Val Gly Asp Ala Ser Leu Leu
210 215 220
Lys Leu Thr Leu Glu Gln Ala Val Lys Gly Leu Asn Glu Ser Lys Lys
225 230 235 240
Pro Ser Lys Pro Ser Asn
245
<210> 81
<211> 246
<212> PRT
<213> RESISTANCE GENE
<400> 81
Met Lys Lys Leu Ser Val Phe Phe Met Phe Leu Phe Cys Ser Ile Ala
1 5 10 15
Ala Ser Gly Glu Ala Leu Pro Asp Leu Lys Ile Glu Lys Leu Asp Glu
20 25 30
Gly Val Tyr Val His Thr Ser Phe Glu Glu Val Asn Gly Trp Gly Val
35 40 45
Val Pro Lys His Gly Leu Val Val Leu Val Asn Thr Asp Ala Tyr Leu
50 55 60
Ile Asp Thr Pro Phe Thr Ala Lys Asp Thr Glu Lys Leu Val Thr Trp
65 70 75 80
Phe Val Glu Arg Gly Tyr Lys Ile Lys Gly Ser Ile Ser Ser His Phe
85 90 95
His Ser Asp Ser Thr Gly Gly Ile Glu Trp Leu Asn Ser Gln Ser Ile
100 105 110
Pro Thr Tyr Ala Ser Glu Leu Thr Asn Glu Leu Leu Lys Lys Asp Gly
115 120 125
Lys Val Gln Ala Lys Asn Ser Phe Ser Gly Ala Ser Tyr Trp Leu Val
130 135 140
Lys Lys Lys Ile Glu Ile Phe Tyr Pro Gly Pro Gly His Thr Pro Asp
145 150 155 160
Asn Val Val Val Trp Leu Pro Glu His Arg Val Leu Phe Gly Gly Cys
165 170 175
Phe Val Lys Pro Tyr Gly Leu Gly Asn Leu Gly Asp Ala Asn Leu Glu
180 185 190
Ala Trp Pro Lys Ser Ala Lys Leu Leu Val Ser Lys Tyr Gly Lys Ala
195 200 205
Lys Leu Val Val Pro Ser His Ser Glu Val Gly Asp Ala Ser Leu Leu
210 215 220
Lys Arg Thr Leu Glu Gln Ala Val Lys Gly Leu Asn Glu Ser Lys Lys
225 230 235 240
Leu Ser Lys Pro Ser Asn
245
<210> 82
<211> 246
<212> PRT
<213> RESISTANCE GENE
<400> 82
Met Ser Lys Leu Ser Val Phe Phe Ile Phe Leu Phe Cys Ser Ile Ala
1 5 10 15
Thr Ala Ala Glu Pro Leu Pro Asp Leu Lys Ile Glu Lys Leu Asp Glu
20 25 30
Gly Val Tyr Val His Thr Ser Phe Glu Glu Val Asn Gly Trp Gly Val
35 40 45
Val Pro Lys His Gly Leu Val Val Leu Val Asp Ala Glu Ala Tyr Leu
50 55 60
Ile Asp Thr Pro Phe Thr Ala Lys Asp Thr Glu Lys Leu Val Thr Trp
65 70 75 80
Phe Val Glu Arg Gly Tyr Lys Ile Lys Gly Ser Ile Ser Ser His Phe
85 90 95
His Ser Asp Ser Thr Gly Gly Ile Glu Trp Leu Asn Ser Gln Ser Ile
100 105 110
Pro Thr Tyr Ala Ser Glu Leu Thr Asn Glu Leu Leu Lys Lys Asp Gly
115 120 125
Lys Val Gln Ala Lys Asn Ser Phe Gly Gly Val Asn Tyr Trp Leu Val
130 135 140
Lys Asn Lys Ile Glu Val Phe Tyr Pro Gly Pro Gly His Thr Pro Asp
145 150 155 160
Asn Leu Val Val Trp Leu Pro Glu Arg Lys Ile Leu Phe Gly Gly Cys
165 170 175
Phe Ile Lys Pro Tyr Gly Leu Gly Asn Leu Gly Asp Ala Asn Leu Glu
180 185 190
Ala Trp Pro Lys Ser Ala Lys Leu Leu Ile Ser Lys Tyr Gly Lys Ala
195 200 205
Lys Leu Val Val Pro Ser His Ser Glu Ala Gly Asp Ala Ser Leu Leu
210 215 220
Lys Leu Thr Leu Glu Gln Ala Val Lys Gly Leu Asn Glu Ser Lys Lys
225 230 235 240
Pro Ser Lys Leu Ser Asn
245
<210> 83
<211> 246
<212> PRT
<213> RESISTANCE GENE
<400> 83
Met Lys Lys Leu Phe Val Leu Cys Val Cys Phe Leu Cys Ser Ile Thr
1 5 10 15
Ala Ala Gly Ala Ala Leu Pro Asp Leu Lys Ile Glu Lys Leu Glu Glu
20 25 30
Gly Val Tyr Val His Thr Ser Phe Glu Glu Val Asn Gly Trp Gly Val
35 40 45
Val Ser Lys His Gly Leu Val Val Leu Val Asn Thr Asp Ala Tyr Leu
50 55 60
Ile Asp Thr Pro Phe Thr Ala Thr Asp Thr Glu Lys Leu Val Asn Trp
65 70 75 80
Phe Val Glu Arg Gly Tyr Lys Ile Lys Gly Thr Ile Ser Ser His Phe
85 90 95
His Ser Asp Ser Thr Gly Gly Ile Glu Trp Leu Asn Ser Gln Ser Ile
100 105 110
Pro Thr Tyr Ala Ser Glu Leu Thr Asn Glu Leu Leu Lys Lys Asp Gly
115 120 125
Lys Val Gln Ala Lys Asn Ser Phe Ser Gly Val Ser Tyr Trp Leu Val
130 135 140
Lys Asn Lys Ile Glu Val Phe Tyr Pro Gly Pro Gly His Thr Gln Asp
145 150 155 160
Asn Val Val Val Trp Leu Pro Glu Lys Lys Ile Leu Phe Gly Gly Cys
165 170 175
Phe Val Lys Pro Asp Gly Leu Gly Asn Leu Gly Asp Ala Asn Leu Glu
180 185 190
Ala Trp Pro Lys Ser Ala Lys Ile Leu Met Ser Lys Tyr Gly Lys Ala
195 200 205
Lys Leu Val Val Ser Ser His Ser Glu Ile Gly Asp Ala Ser Leu Leu
210 215 220
Lys Arg Thr Trp Glu Gln Ala Val Lys Gly Leu Asn Glu Ser Lys Lys
225 230 235 240
Pro Ser Gln Pro Ser Asn
245
<210> 84
<211> 246
<212> PRT
<213> RESISTANCE GENE
<400> 84
Met Ser Lys Leu Phe Val Phe Phe Met Phe Leu Phe Cys Ser Ile Thr
1 5 10 15
Ala Ala Ala Glu Ser Leu Pro Asp Leu Lys Ile Glu Lys Leu Asp Glu
20 25 30
Gly Val Tyr Val His Thr Ser Phe Glu Glu Val Asn Gly Trp Gly Val
35 40 45
Val Pro Lys His Gly Leu Val Val Leu Val Asn Thr Glu Ala Tyr Leu
50 55 60
Ile Asp Thr Pro Phe Thr Ala Lys Asp Thr Glu Lys Leu Val Thr Trp
65 70 75 80
Phe Val Glu Arg Gly Tyr Lys Ile Lys Gly Ser Ile Ser Ser His Phe
85 90 95
His Ser Asp Ser Thr Gly Gly Ile Glu Trp Leu Asn Ser Gln Ser Ile
100 105 110
Pro Thr Tyr Ala Ser Glu Leu Thr Asn Glu Leu Leu Lys Lys Asp Gly
115 120 125
Lys Val Gln Ala Lys Asn Ser Phe Ser Gly Ala Ser Tyr Trp Leu Val
130 135 140
Lys Lys Lys Ile Glu Val Phe Tyr Pro Gly Pro Gly His Thr Pro Asp
145 150 155 160
Asn Val Val Val Trp Leu Pro Glu Asn Arg Val Leu Phe Gly Gly Cys
165 170 175
Phe Val Lys Pro Tyr Gly Leu Gly Asn Leu Gly Asp Ala Asn Val Glu
180 185 190
Ala Trp Pro Lys Ser Ala Lys Leu Leu Met Ser Lys Tyr Gly Lys Ala
195 200 205
Lys Leu Val Val Pro Ser His Ser Glu Val Gly Asp Ala Ser Leu Leu
210 215 220
Lys Arg Thr Leu Glu Gln Ala Val Lys Gly Leu Asn Glu Ser Lys Lys
225 230 235 240
Pro Ser Lys Pro Ser Asn
245
<210> 85
<211> 245
<212> PRT
<213> RESISTANCE GENE
<400> 85
Met Ser Lys Leu Phe Val Phe Phe Met Phe Leu Phe Cys Ser Ile Thr
1 5 10 15
Ala Ala Gly Glu Ser Leu Pro Asp Leu Lys Ile Glu Lys Leu Asp Glu
20 25 30
Gly Val Tyr Val His Thr Ser Phe Glu Glu Val Asn Gly Trp Gly Val
35 40 45
Ile Pro Lys His Gly Leu Val Val Leu Val Asn Thr Asp Ala Tyr Leu
50 55 60
Ile Asp Thr Pro Phe Thr Ala Lys Asp Thr Glu Asn Leu Val Asn Trp
65 70 75 80
Phe Val Glu Arg Gly Tyr Arg Ile Lys Gly Ser Ile Ser Ser His Phe
85 90 95
His Ser Asp Ser Thr Gly Gly Ile Glu Trp Leu Asn Ser Gln Ser Ile
100 105 110
Pro Thr Tyr Ala Ser Glu Leu Thr Asn Glu Leu Leu Lys Lys Asp Gly
115 120 125
Lys Val Gln Ala Lys Tyr Ser Phe Ser Gly Val Ser Tyr Trp Leu Val
130 135 140
Lys Lys Lys Ile Glu Val Phe Tyr Pro Gly Pro Gly His Ala Pro Asp
145 150 155 160
Asn Val Val Val Trp Leu Pro Glu Asn Arg Val Leu Phe Gly Gly Cys
165 170 175
Phe Val Lys Pro Tyr Gly Leu Gly Asn Leu Gly Asp Ala Asn Leu Glu
180 185 190
Ala Trp Pro Lys Ser Ala Lys Leu Leu Met Ser Lys Tyr Ser Lys Ala
195 200 205
Lys Leu Val Val Pro Ser His Ser Asp Ile Gly Asp Ser Ser Leu Leu
210 215 220
Lys Leu Thr Trp Glu Gln Thr Val Lys Gly Phe Asn Glu Ser Lys Lys
225 230 235 240
Ser Thr Thr Ala His
245
<210> 86
<211> 246
<212> PRT
<213> RESISTANCE GENE
<400> 86
Met Lys Lys Leu Phe Val Leu Cys Val Phe Phe Phe Cys Asn Ile Ala
1 5 10 15
Val Ala Glu Glu Ser Leu Pro Asp Leu Lys Ile Glu Lys Leu Glu Glu
20 25 30
Gly Val Tyr Val His Thr Ser Phe Glu Glu Val Lys Gly Trp Ser Val
35 40 45
Val Thr Lys His Gly Leu Val Val Leu Val Lys Asn Asp Ala Tyr Leu
50 55 60
Ile Asp Thr Pro Ile Thr Ala Lys Asp Thr Glu Lys Leu Val Asn Trp
65 70 75 80
Phe Val Glu Arg Gly Tyr Lys Ile Lys Gly Ser Ile Ser Thr His Phe
85 90 95
His Gly Asp Ser Thr Ala Gly Ile Glu Trp Leu Asn Ser Gln Ser Ile
100 105 110
Pro Thr Tyr Ala Ser Glu Leu Thr Asn Glu Leu Leu Lys Lys Asp Asn
115 120 125
Lys Val Gln Ala Lys His Ser Phe Asn Gly Val Ser Tyr Ser Leu Ile
130 135 140
Lys Asn Lys Ile Glu Val Phe Tyr Pro Gly Pro Gly His Thr Gln Asp
145 150 155 160
Asn Val Val Val Trp Leu Pro Glu Lys Lys Ile Leu Phe Gly Gly Cys
165 170 175
Phe Val Lys Pro Asp Gly Leu Gly Tyr Leu Gly Asp Ala Asn Leu Glu
180 185 190
Ala Trp Pro Lys Ser Ala Lys Ile Leu Met Ser Lys Tyr Gly Lys Ala
195 200 205
Lys Leu Val Val Ser Ser His Ser Asp Ile Gly Asp Val Ser Leu Leu
210 215 220
Lys Arg Thr Trp Glu Gln Ala Val Lys Gly Leu Asn Glu Ser Lys Lys
225 230 235 240
Ser Ser Gln Pro Ser Asp
245
<210> 87
<211> 246
<212> PRT
<213> RESISTANCE GENE
<400> 87
Met Asn Lys Leu Ser Val Phe Phe Met Phe Met Phe Cys Ser Ile Thr
1 5 10 15
Ala Ala Gly Glu Ser Leu Pro Asp Leu Lys Ile Glu Lys Leu Asp Glu
20 25 30
Gly Val Tyr Val His Thr Ser Phe Glu Glu Val Asn Gly Trp Gly Val
35 40 45
Val Pro Lys His Gly Leu Val Val Leu Val Asn Thr Glu Ala Tyr Leu
50 55 60
Ile Asp Thr Pro Phe Thr Ala Lys Asp Thr Glu Lys Leu Val Thr Trp
65 70 75 80
Phe Val Glu Arg Gly Tyr Lys Ile Lys Gly Ser Ile Ser Ser His Phe
85 90 95
His Ser Asp Ser Thr Gly Gly Ile Glu Trp Leu Asn Ser Gln Ser Ile
100 105 110
Pro Thr Tyr Ala Ser Glu Leu Thr Asn Glu Leu Leu Lys Lys Asp Gly
115 120 125
Lys Val Gln Ala Lys Asn Ser Phe Ser Gly Gly Ser Tyr Trp Leu Val
130 135 140
Asn Asn Lys Ile Glu Val Phe Tyr Pro Gly Pro Gly His Thr Pro Asp
145 150 155 160
Asn Val Val Val Trp Leu Pro Glu Asn Arg Val Leu Phe Gly Gly Cys
165 170 175
Phe Val Lys Pro Tyr Gly Leu Gly Asn Leu Gly Asp Ala Asn Leu Glu
180 185 190
Ala Trp Pro Lys Ser Ala Lys Ile Leu Met Ser Lys Tyr Gly Lys Ala
195 200 205
Lys Leu Val Val Ser Ser His Ser Glu Thr Gly Asn Ala Ser Leu Leu
210 215 220
Lys Leu Thr Trp Glu Gln Ala Val Lys Gly Leu Lys Glu Ser Lys Lys
225 230 235 240
Pro Ser Leu Pro Ser Asn
245
<210> 88
<211> 246
<212> PRT
<213> RESISTANCE GENE
<400> 88
Met Lys Lys Leu Phe Val Leu Cys Val Phe Phe Leu Cys Asn Ile Ala
1 5 10 15
Ala Ala Asp Asp Ser Leu Pro Asp Leu Lys Ile Glu Lys Leu Glu Lys
20 25 30
Gly Val Tyr Val His Thr Ser Phe Glu Glu Val Lys Gly Trp Gly Val
35 40 45
Val Thr Lys His Gly Leu Val Val Leu Val Lys Asn Asp Ala Tyr Leu
50 55 60
Ile Asp Thr Pro Ile Thr Ala Lys Asp Thr Glu Lys Leu Val Asn Trp
65 70 75 80
Phe Ile Glu His Gly Tyr Arg Ile Lys Gly Ser Ile Ser Thr His Phe
85 90 95
His Gly Asp Ser Thr Ala Gly Ile Glu Trp Leu Asn Ser Gln Ser Ile
100 105 110
Ser Thr Tyr Ala Ser Glu Leu Thr Asn Glu Leu Leu Lys Lys Asp Asn
115 120 125
Lys Val Gln Ala Thr Asn Ser Phe Ser Gly Val Ser Tyr Ser Leu Ile
130 135 140
Lys Asn Lys Ile Glu Val Phe Tyr Pro Gly Pro Gly His Thr Gln Asp
145 150 155 160
Asn Val Val Val Trp Leu Pro Glu Lys Lys Ile Leu Phe Gly Gly Cys
165 170 175
Phe Val Lys Pro Asp Gly Leu Gly Asn Leu Gly Asp Ala Asn Leu Glu
180 185 190
Ala Trp Pro Lys Ser Ala Lys Ile Leu Met Ser Lys Tyr Gly Lys Ala
195 200 205
Lys Leu Val Val Ser Ser His Ser Glu Ile Gly Asn Ala Ser Leu Leu
210 215 220
Gln Arg Thr Trp Glu Gln Ala Val Lys Gly Leu Asn Glu Ser Lys Lys
225 230 235 240
Pro Leu Gln Pro Ser Ser
245
<210> 89
<211> 246
<212> PRT
<213> RESISTANCE GENE
<400> 89
Met Lys Lys Leu Phe Val Leu Cys Val Phe Leu Phe Cys Ser Ile Thr
1 5 10 15
Ala Ala Gly Glu Ser Leu Pro Asp Leu Lys Ile Glu Lys Leu Glu Glu
20 25 30
Gly Val Tyr Val His Thr Ser Phe Glu Glu Val Asn Gly Trp Gly Val
35 40 45
Val Ser Lys His Gly Leu Val Ile Leu Val Asn Thr Asp Ala Tyr Leu
50 55 60
Ile Asp Thr Pro Phe Thr Ala Lys Asp Thr Glu Lys Leu Val Thr Trp
65 70 75 80
Phe Val Glu Arg Gly Tyr Lys Ile Lys Gly Ser Ile Ser Ser His Phe
85 90 95
His Ser Asp Ser Thr Gly Gly Ile Glu Trp Leu Asn Ser Gln Ser Ile
100 105 110
Pro Thr Tyr Ala Ser Glu Leu Thr Asn Asp Leu Leu Lys Gln Asn Gly
115 120 125
Lys Val Gln Ala Lys Asn Ser Phe Ser Gly Val Ser Tyr Trp Leu Val
130 135 140
Lys Asn Lys Ile Glu Val Phe Tyr Pro Gly Pro Gly His Thr Gln Asp
145 150 155 160
Asn Val Val Val Trp Leu Pro Glu Lys Lys Ile Leu Phe Gly Gly Cys
165 170 175
Phe Val Lys Pro Tyr Gly Leu Gly Asn Leu Asp Asp Ala Asn Val Val
180 185 190
Ala Trp Pro His Ser Ala Glu Ile Leu Met Ser Arg Tyr Gly Asn Ala
195 200 205
Lys Leu Val Val Pro Ser His Ser Asp Ile Gly Asp Ala Ser Leu Leu
210 215 220
Lys Leu Thr Trp Glu Gln Ala Val Lys Gly Leu Lys Glu Ser Lys Lys
225 230 235 240
Pro Ser Glu Pro Ser Asn
245
<210> 90
<211> 246
<212> PRT
<213> RESISTANCE GENE
<400> 90
Met Ser Lys Leu Ser Val Phe Phe Ile Phe Leu Phe Cys Ser Ile Ala
1 5 10 15
Thr Ala Ala Glu Ser Leu Pro Asp Leu Lys Ile Glu Lys Leu Asp Glu
20 25 30
Gly Val Tyr Val His Thr Ser Phe Lys Glu Val Asn Gly Trp Gly Val
35 40 45
Val Pro Lys His Gly Leu Val Val Leu Val Asn Ala Glu Ala Tyr Leu
50 55 60
Ile Asp Thr Pro Phe Thr Ala Lys Asp Thr Glu Lys Leu Val Thr Trp
65 70 75 80
Phe Val Glu Arg Gly Tyr Lys Ile Lys Gly Ser Ile Ser Ser His Phe
85 90 95
His Ser Asp Ser Thr Gly Gly Ile Glu Trp Leu Asn Ser Arg Ser Ile
100 105 110
Pro Thr Tyr Ala Ser Glu Leu Thr Asn Glu Leu Leu Lys Lys Asp Gly
115 120 125
Lys Val Gln Ala Thr Asn Ser Phe Ser Gly Val Asn Tyr Trp Leu Val
130 135 140
Lys Asn Lys Ile Glu Val Phe Tyr Pro Gly Pro Gly His Thr Pro Asp
145 150 155 160
Asn Val Val Val Trp Leu Pro Glu Arg Lys Ile Leu Phe Gly Gly Cys
165 170 175
Phe Ile Lys Pro Tyr Gly Leu Gly Asn Leu Gly Asp Ala Asn Ile Glu
180 185 190
Ala Trp Pro Lys Ser Ala Lys Leu Leu Lys Ser Lys Tyr Gly Lys Ala
195 200 205
Lys Leu Val Val Pro Ser His Ser Glu Val Gly Asp Ala Ser Leu Leu
210 215 220
Lys Leu Thr Leu Glu Gln Ala Val Lys Gly Leu Asn Glu Ser Lys Lys
225 230 235 240
Pro Ser Lys Pro Ser Asn
245
<210> 91
<211> 246
<212> PRT
<213> RESISTANCE GENE
<400> 91
Met Lys Lys Leu Phe Val Leu Cys Val Cys Phe Leu Cys Ser Ile Thr
1 5 10 15
Ala Ala Gly Ala Ala Leu Pro Asp Leu Lys Ile Glu Lys Leu Glu Glu
20 25 30
Gly Val Tyr Val His Thr Ser Phe Glu Glu Val Asn Gly Trp Gly Val
35 40 45
Val Ser Lys His Gly Leu Val Val Leu Val Asn Thr Asp Ala Tyr Leu
50 55 60
Ile Asp Thr Pro Phe Thr Ala Thr Asp Thr Glu Lys Leu Val Asn Trp
65 70 75 80
Phe Val Glu Arg Gly Tyr Lys Ile Lys Gly Thr Ile Ser Ser His Phe
85 90 95
His Ser Asp Ser Thr Gly Gly Ile Glu Trp Leu Asn Ser Gln Ser Ile
100 105 110
Pro Thr Tyr Ala Ser Glu Leu Thr Asn Glu Leu Leu Lys Lys Asp Gly
115 120 125
Lys Val Gln Ala Lys Asn Ser Phe Ser Gly Val Ser Tyr Trp Leu Val
130 135 140
Lys Asn Lys Ile Glu Val Phe Tyr Pro Gly Pro Gly His Thr Gln Asp
145 150 155 160
Asn Val Val Val Trp Leu Pro Glu Lys Lys Ile Leu Phe Gly Gly Cys
165 170 175
Phe Val Lys Pro Asp Gly Leu Gly Asn Leu Gly Asp Ala Asn Leu Glu
180 185 190
Ala Trp Pro Lys Ser Ala Lys Ile Leu Met Ser Lys Tyr Val Lys Ala
195 200 205
Lys Leu Val Val Ser Ser His Ser Glu Ile Gly Asp Ala Ser Leu Leu
210 215 220
Lys Arg Thr Trp Glu Gln Ala Val Lys Gly Leu Asn Glu Ser Lys Lys
225 230 235 240
Pro Ser Gln Pro Ser Asn
245
<210> 92
<211> 246
<212> PRT
<213> RESISTANCE GENE
<400> 92
Met Lys Lys Leu Phe Val Leu Cys Val Cys Phe Leu Cys Ser Ile Thr
1 5 10 15
Ala Ala Gly Ala Ala Leu Pro Asp Leu Lys Ile Glu Lys Leu Glu Glu
20 25 30
Gly Val Tyr Val His Thr Ser Phe Glu Glu Val Asn Gly Trp Gly Val
35 40 45
Val Ser Lys His Gly Leu Val Val Leu Val Asn Thr Asp Ala Tyr Leu
50 55 60
Ile Asp Thr Pro Phe Thr Ala Thr Asp Thr Glu Lys Leu Val Asn Trp
65 70 75 80
Phe Val Glu Arg Gly Tyr Lys Ile Lys Gly Thr Ile Ser Ser His Phe
85 90 95
His Ser Asp Ser Thr Gly Gly Ile Glu Trp Leu Asn Ser Gln Ser Ile
100 105 110
Pro Thr Tyr Ala Ser Glu Leu Thr Asn Glu Leu Leu Lys Lys Asp Gly
115 120 125
Lys Val Gln Ala Lys Asn Ser Phe Ser Gly Val Ser Tyr Trp Leu Val
130 135 140
Lys Asn Lys Ile Glu Val Phe Tyr Pro Gly Pro Gly His Thr Gln Asp
145 150 155 160
Asn Val Val Val Trp Leu Pro Glu Lys Lys Ile Leu Phe Gly Gly Cys
165 170 175
Phe Val Lys Pro Asp Gly Leu Gly Asn Leu Gly Asp Ala Asn Leu Glu
180 185 190
Ala Trp Pro Lys Ser Ala Lys Ile Leu Met Ser Lys Tyr Gly Lys Ala
195 200 205
Lys Leu Val Val Ser Ser His Ser Glu Ile Gly Asp Ala Ser Leu Leu
210 215 220
Lys Arg Thr Trp Glu Gln Ala Val Lys Gly Leu Asn Glu Ser Arg Lys
225 230 235 240
Pro Ser Gln Pro Ser Asn
245
<210> 93
<211> 246
<212> PRT
<213> RESISTANCE GENE
<400> 93
Met Ser Lys Leu Ser Val Phe Phe Ile Phe Leu Phe Cys Ser Ile Ala
1 5 10 15
Thr Ala Ala Glu Ser Leu Pro Asp Leu Lys Ile Glu Lys Leu Asp Glu
20 25 30
Gly Val Tyr Val His Thr Ser Phe Glu Glu Val Asn Gly Trp Gly Val
35 40 45
Val Pro Lys His Gly Leu Val Val Leu Val Asn Ala Glu Ala Tyr Leu
50 55 60
Ile Asp Thr Pro Phe Thr Ala Lys Asp Thr Glu Lys Leu Val Thr Trp
65 70 75 80
Phe Val Glu Arg Gly Tyr Lys Ile Lys Gly Ser Ile Ser Ser His Phe
85 90 95
His Ser Asp Ser Thr Gly Gly Ile Glu Trp Leu Asn Ser Arg Ser Ile
100 105 110
Pro Thr Tyr Ala Ser Glu Leu Thr Asn Glu Leu Leu Lys Lys Asp Gly
115 120 125
Lys Val Gln Ala Thr Asn Ser Phe Ser Gly Val Asn Tyr Trp Leu Val
130 135 140
Lys Asn Lys Ile Glu Val Phe Tyr Pro Gly Pro Gly His Thr Pro Asp
145 150 155 160
Asn Val Val Val Trp Leu Pro Glu Arg Lys Ile Leu Phe Gly Gly Cys
165 170 175
Phe Ile Lys Pro Tyr Gly Leu Gly Asn Leu Ser Asp Ala Asn Ile Glu
180 185 190
Ala Trp Pro Lys Ser Ala Lys Leu Leu Lys Ser Lys Tyr Gly Lys Ala
195 200 205
Lys Leu Val Val Pro Gly His Ser Glu Val Gly Asp Ala Ser Leu Leu
210 215 220
Lys Leu Thr Leu Glu Gln Ala Val Lys Gly Leu Asn Glu Ser Lys Lys
225 230 235 240
Pro Ser Lys Pro Ser Asn
245
<210> 94
<211> 246
<212> PRT
<213> RESISTANCE GENE
<400> 94
Met Ser Lys Leu Ser Val Phe Phe Ile Phe Leu Phe Cys Ser Ile Ala
1 5 10 15
Thr Ala Ala Glu Pro Leu Pro Asp Leu Lys Ile Glu Lys Leu Asp Glu
20 25 30
Gly Val Tyr Val His Thr Ser Phe Glu Glu Val Asn Gly Trp Gly Val
35 40 45
Phe Pro Lys His Gly Leu Val Val Leu Val Asp Ala Glu Ala Tyr Leu
50 55 60
Ile Asp Thr Pro Phe Thr Ala Lys Asp Thr Glu Lys Leu Val Thr Trp
65 70 75 80
Phe Val Glu Arg Gly Tyr Lys Ile Lys Gly Ser Ile Ser Ser His Phe
85 90 95
His Ser Asp Ser Thr Gly Gly Ile Glu Trp Leu Asn Ser Gln Ser Ile
100 105 110
Pro Thr Tyr Ala Ser Glu Leu Thr Asn Glu Leu Leu Lys Lys Asp Gly
115 120 125
Lys Val Gln Ala Lys Asn Ser Phe Gly Gly Val Asn Tyr Trp Leu Val
130 135 140
Lys Asn Lys Ile Glu Val Phe Tyr Pro Gly Pro Gly His Thr Pro Asp
145 150 155 160
Asn Leu Val Val Trp Leu Pro Glu Arg Lys Ile Leu Phe Gly Gly Cys
165 170 175
Phe Ile Lys Pro Tyr Gly Leu Gly Asn Leu Gly Asp Ala Asn Leu Glu
180 185 190
Ala Trp Pro Lys Ser Ala Lys Leu Leu Ile Ser Lys Tyr Gly Lys Ala
195 200 205
Lys Leu Val Val Pro Ser His Ser Glu Ala Gly Asp Ala Ser Leu Leu
210 215 220
Lys Leu Thr Leu Glu Gln Ala Val Lys Gly Leu Asn Glu Ser Lys Lys
225 230 235 240
Pro Ser Lys Leu Ser Asn
245
<210> 95
<211> 246
<212> PRT
<213> RESISTANCE GENE
<400> 95
Met Lys Lys Leu Phe Val Leu Cys Val Phe Val Phe Cys Ser Ile Thr
1 5 10 15
Val Ala Gly Glu Thr Leu Pro Asn Leu Arg Val Glu Lys Leu Glu Glu
20 25 30
Gly Val Tyr Val His Thr Ser Tyr Glu Glu Val Lys Gly Trp Gly Val
35 40 45
Val Thr Lys His Gly Leu Val Val Leu Ile Gly Ala Asp Ala Tyr Leu
50 55 60
Ile Asp Thr Pro Phe Thr Ala Lys Asp Thr Glu Lys Leu Val Asn Trp
65 70 75 80
Phe Val Glu Arg Gly Tyr Lys Ile Lys Gly Thr Val Ser Ser His Phe
85 90 95
His Ser Asp Ser Thr Gly Gly Ile Glu Trp Leu Asn Ser Gln Ser Ile
100 105 110
Pro Thr Tyr Ala Ser Glu Leu Thr Asn Glu Leu Leu Lys Lys Asp Gly
115 120 125
Lys Val Gln Ala Lys Asn Ser Phe Asp Gly Val Ser Tyr Trp Leu Ala
130 135 140
Lys Asp Lys Ile Glu Val Phe Tyr Pro Gly Pro Gly His Thr Gln Asp
145 150 155 160
Asn Val Val Val Trp Leu Pro Glu Lys Glu Ile Leu Phe Gly Gly Cys
165 170 175
Phe Val Lys Pro His Gly Leu Gly Asn Leu Gly Asp Ala Asn Leu Glu
180 185 190
Ala Trp Pro Glu Ser Ala Lys Ile Leu Met Glu Lys Tyr Gly Lys Ala
195 200 205
Lys Leu Val Val Ser Gly His Ser Glu Thr Gly Asp Ala Thr His Leu
210 215 220
Lys Arg Thr Trp Glu Gln Ala Val Lys Gly Leu Lys Glu Ser Lys Lys
225 230 235 240
Thr Leu Gln Pro Ser Asn
245
<210> 96
<211> 246
<212> PRT
<213> RESISTANCE GENE
<400> 96
Met Ser Lys Leu Ser Val Phe Phe Ile Phe Leu Phe Cys Ser Ile Ala
1 5 10 15
Thr Ala Ala Glu Ser Leu Pro Asp Leu Lys Ile Glu Lys Leu Asp Glu
20 25 30
Gly Val Tyr Val His Thr Ser Phe Glu Glu Val Asn Gly Trp Gly Val
35 40 45
Val Pro Lys His Gly Leu Val Val Leu Val Asn Ala Glu Ala Tyr Leu
50 55 60
Ile Asp Thr Pro Phe Thr Ala Lys Asp Thr Glu Lys Leu Val Thr Trp
65 70 75 80
Phe Val Glu Arg Gly Tyr Lys Ile Lys Gly Ser Ile Ser Ser His Phe
85 90 95
His Ser Asp Ser Thr Gly Gly Ile Gly Trp Leu Asn Ser Arg Ser Ile
100 105 110
Pro Thr Tyr Ala Ser Glu Leu Thr Asn Glu Leu Leu Lys Lys Asp Gly
115 120 125
Lys Val Gln Ala Thr Asn Ser Phe Ser Gly Val Asn Tyr Trp Leu Val
130 135 140
Lys Asn Lys Ile Glu Val Phe Tyr Pro Gly Pro Gly His Thr Pro Asp
145 150 155 160
Asn Val Val Val Trp Leu Pro Glu Arg Lys Ile Leu Phe Gly Gly Cys
165 170 175
Phe Ile Lys Pro Tyr Gly Leu Gly Asn Leu Gly Asp Ala Asn Ile Glu
180 185 190
Ala Trp Pro Lys Ser Ala Lys Leu Leu Lys Ser Lys Tyr Gly Lys Ala
195 200 205
Lys Leu Val Val Pro Gly His Ser Glu Val Gly Asp Ala Ser Leu Leu
210 215 220
Lys Leu Thr Leu Glu Gln Ala Val Lys Gly Leu Asn Glu Ser Lys Lys
225 230 235 240
Pro Ser Lys Pro Ser Asn
245
<210> 97
<211> 246
<212> PRT
<213> RESISTANCE GENE
<400> 97
Met Ser Lys Leu Ser Val Phe Phe Ile Phe Leu Phe Cys Ser Ile Ala
1 5 10 15
Thr Ala Ala Glu Ser Leu Pro Asp Leu Lys Ile Glu Lys Leu Asp Glu
20 25 30
Gly Val Tyr Val His Thr Ser Phe Glu Glu Val Asn Gly Trp Gly Val
35 40 45
Val Pro Lys His Gly Leu Val Val Leu Val Asn Ala Glu Ala Tyr Leu
50 55 60
Ile Asp Thr Pro Phe Thr Ala Lys Asp Thr Glu Lys Leu Val Thr Trp
65 70 75 80
Phe Val Glu Arg Gly Tyr Lys Ile Lys Gly Ser Ile Ser Ser His Phe
85 90 95
His Ser Asp Ser Thr Gly Gly Ile Glu Trp Leu Asn Ser Arg Ser Ile
100 105 110
Pro Thr Tyr Ala Ser Glu Leu Thr Asn Glu Leu Leu Lys Lys Asp Gly
115 120 125
Lys Val Gln Ala Thr Asn Ser Phe Ser Gly Val Asn Tyr Trp Leu Val
130 135 140
Lys Asn Lys Ile Glu Val Phe Tyr Pro Gly Pro Gly His Thr Pro Asp
145 150 155 160
Asn Val Val Val Trp Leu Pro Glu Arg Lys Ile Leu Phe Gly Gly Cys
165 170 175
Phe Ile Lys Pro Tyr Gly Leu Gly Asn Leu Gly Asp Ala Asn Ile Glu
180 185 190
Ala Trp Pro Lys Ser Ala Lys Leu Leu Lys Ser Lys Tyr Gly Lys Ala
195 200 205
Lys Leu Val Val Pro Gly His Ser Glu Val Gly Asp Ala Ser Leu Leu
210 215 220
Lys Leu Thr Leu Glu Gln Ala Val Lys Gly Leu Asn Glu Ser Lys Lys
225 230 235 240
Pro Ser Lys Pro Ser Asn
245
<210> 98
<211> 246
<212> PRT
<213> RESISTANCE GENE
<400> 98
Met Ser Lys Leu Ser Val Phe Phe Ile Phe Leu Phe Cys Ser Ile Ala
1 5 10 15
Thr Ala Ala Glu Ser Leu Pro Asp Leu Lys Ile Glu Lys Leu Asp Glu
20 25 30
Gly Val Tyr Val His Thr Ser Phe Glu Glu Val Asn Gly Trp Gly Val
35 40 45
Phe Pro Lys His Gly Leu Val Val Leu Val Asn Ala Glu Ala Tyr Leu
50 55 60
Ile Asp Thr Pro Phe Thr Ala Lys Asp Thr Glu Lys Leu Val Thr Trp
65 70 75 80
Phe Val Glu Arg Gly Tyr Lys Ile Lys Gly Ser Ile Ser Ser His Phe
85 90 95
His Ser Asp Ser Thr Gly Gly Ile Glu Trp Leu Asn Ser Arg Ser Ile
100 105 110
Pro Thr Tyr Ala Ser Glu Leu Thr Asn Glu Leu Leu Lys Lys Asp Gly
115 120 125
Lys Val Gln Ala Thr Asn Ser Phe Ser Gly Val Asn Tyr Trp Leu Val
130 135 140
Lys Asn Lys Ile Glu Val Phe Tyr Pro Gly Pro Gly His Thr Pro Asp
145 150 155 160
Asn Val Val Val Trp Leu Pro Glu Arg Lys Ile Leu Phe Gly Gly Cys
165 170 175
Phe Ile Lys Pro Tyr Gly Leu Gly Asn Leu Gly Asp Ala Asn Ile Glu
180 185 190
Ala Trp Pro Lys Ser Ala Lys Leu Leu Lys Ser Lys Tyr Gly Lys Ala
195 200 205
Lys Leu Val Val Pro Ser His Ser Glu Val Gly Asp Ala Ser Leu Leu
210 215 220
Lys Leu Thr Leu Glu Gln Ala Val Lys Gly Leu Asn Glu Ser Lys Lys
225 230 235 240
Pro Ser Lys Pro Ser Asn
245
<210> 99
<211> 245
<212> PRT
<213> RESISTANCE GENE
<400> 99
Met Lys Lys Leu Phe Val Leu Cys Ile Phe Leu Phe Cys Ser Ile Thr
1 5 10 15
Ala Ala Gly Ala Ser Leu Pro Asp Leu Lys Ile Glu Lys Leu Glu Glu
20 25 30
Gly Val Tyr Val His Thr Ser Phe Glu Glu Val Asn Gly Trp Gly Val
35 40 45
Val Ser Lys His Gly Leu Val Val Leu Val Asn Thr Asp Ala Tyr Leu
50 55 60
Ile Asp Thr Pro Phe Thr Ala Lys Asp Thr Glu Lys Leu Val Asn Trp
65 70 75 80
Phe Val Glu Arg Gly Tyr Lys Ile Lys Gly Ser Ile Ser Ser His Phe
85 90 95
His Ser Asp Ser Thr Gly Gly Ile Glu Trp Leu Asn Ser Gln Ser Ile
100 105 110
Pro Thr Tyr Ala Ser Val Leu Thr Asn Glu Leu Leu Lys Lys Asp Gly
115 120 125
Lys Val Gln Ala Lys Asn Ser Phe Ser Gly Val Ser Tyr Trp Leu Val
130 135 140
Lys Asn Lys Ile Glu Val Phe Tyr Pro Gly Pro Gly His Thr Gln Asp
145 150 155 160
Asn Val Val Val Trp Leu Pro Lys Asn Lys Ile Leu Phe Gly Gly Cys
165 170 175
Phe Val Lys Pro Tyr Gly Leu Gly Asn Leu Asp Asp Ala Asn Val Glu
180 185 190
Ala Trp Pro His Ser Ala Glu Lys Leu Ile Ser Lys Tyr Gly Asn Ala
195 200 205
Lys Leu Val Val Pro Ser His Ser Asp Ile Gly Asp Ala Ser Leu Leu
210 215 220
Lys Leu Thr Trp Glu Gln Ala Val Lys Gly Leu Asn Glu Ser Lys Lys
225 230 235 240
Ser Asn Thr Val His
245
<210> 100
<211> 246
<212> PRT
<213> RESISTANCE GENE
<400> 100
Met Lys Lys Leu Phe Val Leu Cys Val Cys Phe Leu Cys Ser Ile Thr
1 5 10 15
Ala Ala Gly Ala Ala Leu Pro Asp Leu Lys Ile Glu Lys Leu Glu Glu
20 25 30
Gly Val Tyr Val His Thr Ser Phe Glu Glu Val Asn Gly Trp Gly Val
35 40 45
Phe Ser Lys His Gly Leu Val Val Leu Val Asn Thr Asp Ala Tyr Leu
50 55 60
Ile Asp Thr Pro Phe Thr Ala Thr Asp Thr Glu Lys Leu Val Asn Trp
65 70 75 80
Phe Val Glu Arg Gly Tyr Lys Ile Lys Gly Thr Ile Ser Ser His Phe
85 90 95
His Ser Asp Ser Thr Gly Gly Ile Glu Trp Leu Asn Ser Gln Ser Ile
100 105 110
Pro Thr Tyr Ala Ser Glu Leu Thr Asn Glu Leu Leu Lys Lys Asp Gly
115 120 125
Lys Val Gln Ala Lys Asn Ser Phe Ser Gly Val Ser Tyr Trp Leu Val
130 135 140
Lys Asn Lys Ile Glu Val Phe Tyr Pro Gly Pro Gly His Thr Gln Asp
145 150 155 160
Asn Val Val Val Trp Leu Pro Glu Lys Lys Ile Leu Phe Gly Gly Cys
165 170 175
Phe Val Lys Pro Asp Gly Leu Gly Asn Leu Gly Asp Ala Asn Leu Glu
180 185 190
Ala Trp Pro Lys Ser Ala Lys Ile Leu Met Ser Lys Tyr Val Lys Ala
195 200 205
Lys Leu Val Val Ser Ser His Ser Glu Ile Gly Asp Ala Ser Leu Leu
210 215 220
Lys Arg Thr Trp Glu Gln Ala Val Lys Gly Leu Asn Glu Ser Lys Lys
225 230 235 240
Pro Ser Gln Pro Ser Asn
245
<210> 101
<211> 245
<212> PRT
<213> RESISTANCE GENE
<400> 101
Met Lys Lys Leu Phe Val Leu Cys Ile Phe Leu Phe Cys Ser Ile Thr
1 5 10 15
Ala Ala Gly Ala Ser Leu Pro Asp Leu Lys Ile Glu Lys Leu Glu Glu
20 25 30
Gly Val Tyr Val His Thr Ser Phe Glu Glu Val Asn Gly Trp Gly Val
35 40 45
Ala Ser Lys His Gly Leu Val Val Leu Val Asn Thr Asp Ala Tyr Leu
50 55 60
Ile Asp Thr Pro Phe Thr Ala Lys Asp Thr Glu Lys Leu Val Asn Trp
65 70 75 80
Phe Val Glu Arg Gly Tyr Lys Ile Lys Gly Ser Ile Ser Ser His Phe
85 90 95
His Ser Asp Ser Thr Gly Gly Ile Glu Trp Leu Asn Ser Gln Ser Ile
100 105 110
Pro Thr Tyr Ala Ser Val Leu Thr Asn Glu Leu Leu Lys Lys Asp Gly
115 120 125
Lys Val Gln Ala Lys Asn Ser Phe Ser Gly Val Ser Tyr Trp Leu Val
130 135 140
Lys Asn Lys Ile Glu Val Phe Tyr Pro Gly Pro Gly His Thr Gln Asp
145 150 155 160
Asn Val Val Val Trp Leu Pro Lys Asn Lys Ile Leu Phe Gly Gly Cys
165 170 175
Phe Val Lys Pro Tyr Gly Leu Gly Asn Leu Asp Asp Ala Asn Val Glu
180 185 190
Ala Trp Pro His Ser Ala Glu Lys Leu Ile Ser Lys Tyr Gly Asn Ala
195 200 205
Lys Leu Val Val Pro Ser His Ser Asp Ile Gly Asp Ala Ser Leu Leu
210 215 220
Lys Leu Thr Trp Glu Gln Ala Val Lys Gly Leu Asn Glu Ser Lys Lys
225 230 235 240
Ser Asn Thr Val His
245
<210> 102
<211> 246
<212> PRT
<213> RESISTANCE GENE
<400> 102
Met Lys Lys Leu Phe Val Leu Cys Val Cys Phe Leu Cys Ser Ile Thr
1 5 10 15
Ala Ala Gly Ala Arg Leu Pro Asp Leu Lys Ile Glu Lys Leu Glu Glu
20 25 30
Gly Val Tyr Val His Thr Ser Phe Glu Glu Val Asn Gly Trp Gly Val
35 40 45
Val Ser Lys His Gly Leu Val Val Leu Val Asn Thr Asp Ala Tyr Leu
50 55 60
Ile Asp Thr Pro Phe Thr Ala Thr Asp Thr Glu Lys Leu Val Asn Trp
65 70 75 80
Phe Val Glu Arg Gly Tyr Lys Ile Lys Gly Thr Ile Ser Ser His Phe
85 90 95
His Ser Asp Ser Thr Gly Gly Ile Glu Trp Leu Asn Ser Gln Ser Ile
100 105 110
Pro Thr Tyr Ala Ser Glu Leu Thr Asn Glu Leu Leu Lys Lys Asp Gly
115 120 125
Lys Val Gln Ala Lys Asn Ser Phe Ser Gly Val Ser Tyr Trp Leu Val
130 135 140
Lys Asn Lys Ile Glu Val Phe Tyr Pro Gly Pro Gly His Thr Gln Asp
145 150 155 160
Asn Val Val Val Trp Leu Pro Glu Lys Lys Ile Leu Phe Gly Gly Cys
165 170 175
Phe Val Lys Pro Asp Gly Leu Gly Asn Leu Gly Asp Ala Asn Leu Glu
180 185 190
Ala Trp Pro Lys Ser Ala Lys Ile Leu Met Ser Lys Tyr Val Lys Ala
195 200 205
Lys Leu Val Val Ser Ser His Ser Glu Ile Gly Asp Ala Ser Leu Leu
210 215 220
Lys Arg Thr Trp Glu Gln Ala Val Lys Gly Leu Asn Glu Ser Lys Lys
225 230 235 240
Pro Ser Gln Pro Ser Asn
245
<210> 103
<211> 246
<212> PRT
<213> RESISTANCE GENE
<400> 103
Met Lys Lys Leu Phe Val Leu Cys Ile Phe Leu Phe Leu Ser Ile Thr
1 5 10 15
Ala Ser Gly Glu Val Leu Pro Asp Leu Lys Ile Glu Lys Leu Glu Glu
20 25 30
Gly Val Tyr Leu His Thr Ser Phe Glu Glu Val Ser Gly Trp Gly Val
35 40 45
Val Thr Lys His Gly Leu Val Val Leu Val Asn Asn Asp Ala Tyr Leu
50 55 60
Ile Asp Thr Pro Phe Thr Asn Lys Asp Thr Glu Lys Leu Val Ala Trp
65 70 75 80
Phe Val Gly Arg Gly Phe Thr Ile Lys Gly Ser Val Ser Ser His Phe
85 90 95
His Ser Asp Ser Thr Gly Gly Ile Glu Trp Leu Asn Ser Gln Ser Ile
100 105 110
Pro Thr Tyr Ala Ser Glu Leu Thr Asn Glu Leu Leu Lys Lys Asn Gly
115 120 125
Lys Val Gln Ala Thr Asn Ser Phe Ser Gly Val Ser Tyr Trp Leu Val
130 135 140
Lys Asn Lys Ile Glu Ile Phe Tyr Pro Gly Pro Gly His Thr Gln Asp
145 150 155 160
Asn Val Val Val Trp Leu Pro Glu Asn Lys Ile Leu Phe Gly Gly Cys
165 170 175
Phe Val Lys Pro Asp Gly Leu Gly Asn Leu Asp Asp Ala Asn Leu Lys
180 185 190
Ala Trp Pro Lys Ser Ala Lys Ile Leu Met Ser Lys Tyr Gly Lys Ala
195 200 205
Lys Leu Val Val Ser Gly His Ser Glu Ile Gly Asn Ala Ser Leu Leu
210 215 220
Lys Leu Thr Trp Glu Gln Ala Val Lys Gly Leu Lys Glu Ser Lys Lys
225 230 235 240
Pro Leu Leu Pro Ser Asn
245
<210> 104
<211> 246
<212> PRT
<213> RESISTANCE GENE
<400> 104
Met Lys Lys Leu Phe Val Leu Cys Val Cys Phe Phe Cys Ser Ile Thr
1 5 10 15
Ala Ala Gly Ala Ala Leu Pro Asp Leu Lys Ile Glu Lys Leu Glu Glu
20 25 30
Gly Val Phe Val His Thr Ser Phe Glu Glu Val Asn Gly Trp Gly Val
35 40 45
Val Thr Lys His Gly Leu Val Val Leu Val Asn Thr Asp Ala Tyr Leu
50 55 60
Ile Asp Thr Pro Phe Thr Ala Thr Asp Thr Glu Lys Leu Val Asn Trp
65 70 75 80
Phe Val Glu Arg Gly Tyr Glu Ile Lys Gly Thr Ile Ser Ser His Phe
85 90 95
His Ser Asp Ser Thr Gly Gly Ile Glu Trp Leu Asn Ser Gln Ser Ile
100 105 110
Pro Thr Tyr Ala Ser Glu Leu Thr Asn Glu Leu Leu Lys Lys Ser Gly
115 120 125
Lys Val Gln Ala Lys Tyr Ser Phe Ser Glu Val Ser Tyr Trp Leu Val
130 135 140
Lys Asn Lys Ile Glu Val Phe Tyr Pro Gly Pro Gly His Thr Gln Asp
145 150 155 160
Asn Leu Val Val Trp Leu Pro Glu Ser Lys Ile Leu Phe Gly Gly Cys
165 170 175
Phe Ile Lys Pro His Gly Leu Gly Asn Leu Gly Asp Ala Asn Leu Glu
180 185 190
Ala Trp Pro Lys Ser Ala Lys Ile Leu Met Ser Lys Tyr Gly Lys Ala
195 200 205
Lys Leu Val Val Ser Ser His Ser Glu Lys Gly Asp Ala Ser Leu Met
210 215 220
Lys Arg Thr Trp Glu Gln Ala Leu Lys Gly Leu Lys Glu Ser Lys Lys
225 230 235 240
Thr Ser Ser Pro Ser Asn
245
<210> 105
<211> 246
<212> PRT
<213> RESISTANCE GENE
<400> 105
Met Lys Lys Leu Phe Val Leu Cys Ile Phe Leu Phe Cys Ser Ile Thr
1 5 10 15
Ala Ala Gly Glu Ser Leu Pro Asp Leu Lys Ile Glu Lys Leu Glu Asp
20 25 30
Gly Val Tyr Val His Thr Ser Phe Glu Glu Val Asn Gly Trp Gly Val
35 40 45
Val Thr Lys His Gly Leu Val Phe Leu Val Asn Thr Asp Ala Tyr Leu
50 55 60
Ile Asp Thr Pro Phe Ala Ala Lys Asp Thr Glu Lys Leu Val Asn Trp
65 70 75 80
Phe Val Glu Arg Gly Tyr Lys Ile Lys Gly Ser Ile Ser Ser His Phe
85 90 95
His Ser Asp Ser Ser Gly Gly Ile Glu Trp Leu Asn Ser Gln Ser Ile
100 105 110
Pro Thr Tyr Ala Ser Glu Leu Thr Asn Glu Leu Leu Lys Lys Asn Gly
115 120 125
Lys Val Gln Ala Lys Asn Ser Phe Ser Gly Val Ser Tyr Trp Leu Leu
130 135 140
Lys Asn Lys Ile Glu Ile Phe Tyr Pro Gly Pro Gly His Thr Gln Asp
145 150 155 160
Asn Val Val Val Trp Leu Pro Glu Lys Lys Ile Leu Phe Gly Gly Cys
165 170 175
Phe Val Lys Pro Tyr Gly Leu Gly Asn Leu Asp Asp Ala Asn Val Glu
180 185 190
Ala Trp Pro His Ser Ala Glu Ile Leu Met Ser Arg Tyr Gly Asn Ala
195 200 205
Lys Leu Val Val Pro Ser His Ser Asp Val Gly Asp Ala Ser Leu Leu
210 215 220
Lys Leu Thr Trp Glu Gln Ala Val Lys Gly Leu Lys Glu Ser Lys Lys
225 230 235 240
Pro Ser Gln Pro Ser Asn
245
<210> 106
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 106
Asp Thr Glu Asn Leu Val Asn Trp Phe Val Glu Arg
1 5 10
<210> 107
<211> 10
<212> PRT
<213> RESISTANCE GENE
<400> 107
Glu Ile Leu Phe Gly Gly Cys Phe Val Lys
1 5 10
<210> 108
<211> 10
<212> PRT
<213> RESISTANCE GENE
<400> 108
Glu Val Asn Gly Trp Gly Val Val Pro Lys
1 5 10
<210> 109
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 109
Gly Asp Ala Ser Leu Met Lys
1 5
<210> 110
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 110
Gly Phe Asn Glu Ser Lys
1 5
<210> 111
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 111
Gly Phe Thr Ile Lys
1 5
<210> 112
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 112
Gly Leu Asn Glu Ser Lys
1 5
<210> 113
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 113
Gly Leu Asn Glu Ser Arg
1 5
<210> 114
<211> 21
<212> PRT
<213> RESISTANCE GENE
<400> 114
Gly Ser Ile Ser Ser His Phe His Ser Asp Ser Thr Gly Gly Ile Glu
1 5 10 15
Trp Leu Asn Ser Arg
20
<210> 115
<211> 21
<212> PRT
<213> RESISTANCE GENE
<400> 115
Gly Ser Ile Ser Ser His Phe His Ser Asp Ser Thr Gly Gly Ile Gly
1 5 10 15
Trp Leu Asn Ser Arg
20
<210> 116
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 116
Gly Val Tyr Val His Thr Ser Phe Glu Glu Val Lys
1 5 10
<210> 117
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 117
Gly Trp Gly Val Val Thr Lys
1 5
<210> 118
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 118
Gly Trp Ser Val Val Thr Lys
1 5
<210> 119
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 119
Gly Tyr Glu Ile Lys
1 5
<210> 120
<211> 21
<212> PRT
<213> RESISTANCE GENE
<400> 120
His Gly Leu Val Phe Leu Val Asn Thr Asp Ala Tyr Leu Ile Asp Thr
1 5 10 15
Pro Phe Ala Ala Lys
20
<210> 121
<211> 21
<212> PRT
<213> RESISTANCE GENE
<400> 121
His Gly Leu Val Ile Leu Val Asn Thr Asp Ala Tyr Leu Ile Asp Thr
1 5 10 15
Pro Phe Thr Ala Lys
20
<210> 122
<211> 21
<212> PRT
<213> RESISTANCE GENE
<400> 122
His Gly Leu Val Val Leu Ile Gly Ala Asp Ala Tyr Leu Ile Asp Thr
1 5 10 15
Pro Phe Thr Ala Lys
20
<210> 123
<211> 21
<212> PRT
<213> RESISTANCE GENE
<400> 123
His Gly Leu Val Val Leu Val Asp Ala Glu Ala Tyr Leu Ile Asp Thr
1 5 10 15
Pro Phe Thr Ala Lys
20
<210> 124
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 124
His Gly Leu Val Val Leu Val Lys
1 5
<210> 125
<211> 21
<212> PRT
<213> RESISTANCE GENE
<400> 125
His Gly Leu Val Val Leu Val Asn Ala Glu Ala Tyr Leu Ile Asp Thr
1 5 10 15
Pro Phe Thr Ala Lys
20
<210> 126
<211> 21
<212> PRT
<213> RESISTANCE GENE
<400> 126
His Gly Leu Val Val Leu Val Asn Asn Asp Ala Tyr Leu Ile Asp Thr
1 5 10 15
Pro Phe Thr Asn Lys
20
<210> 127
<211> 21
<212> PRT
<213> RESISTANCE GENE
<400> 127
His Gly Leu Val Val Leu Val Asn Thr Asp Ala Tyr Leu Ile Asp Thr
1 5 10 15
Pro Phe Thr Ala Lys
20
<210> 128
<211> 21
<212> PRT
<213> RESISTANCE GENE
<400> 128
His Gly Leu Val Val Leu Val Asn Thr Glu Ala Tyr Leu Ile Asp Thr
1 5 10 15
Pro Phe Thr Ala Lys
20
<210> 129
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 129
His Ser Phe Asn Gly Val Ser Tyr Ser Leu Ile Lys
1 5 10
<210> 130
<211> 21
<212> PRT
<213> RESISTANCE GENE
<400> 130
Ile Glu Val Phe Tyr Pro Gly Pro Gly His Thr Gln Asp Asn Val Val
1 5 10 15
Val Trp Leu Pro Lys
20
<210> 131
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 131
Ile Leu Phe Gly Gly Cys Phe Ile Lys
1 5
<210> 132
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 132
Ile Leu Phe Gly Gly Cys Phe Val Lys
1 5
<210> 133
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 133
Ile Leu Met Glu Lys
1 5
<210> 134
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 134
Ile Leu Met Ser Lys
1 5
<210> 135
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 135
Leu Asp Glu Gly Val Tyr Val His Thr Ser Phe Lys
1 5 10
<210> 136
<211> 15
<212> PRT
<213> RESISTANCE GENE
<400> 136
Leu Glu Glu Gly Val Tyr Val His Thr Ser Phe Glu Glu Val Lys
1 5 10 15
<210> 137
<211> 15
<212> PRT
<213> RESISTANCE GENE
<400> 137
Leu Glu Glu Gly Val Tyr Val His Thr Ser Tyr Glu Glu Val Lys
1 5 10 15
<210> 138
<211> 18
<212> PRT
<213> RESISTANCE GENE
<400> 138
Leu Phe Val Leu Cys Val Cys Phe Leu Cys Ser Ile Thr Ala Ala Gly
1 5 10 15
Ala Arg
<210> 139
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 139
Leu Leu Ile Ser Lys
1 5
<210> 140
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 140
Leu Leu Met Ser Lys
1 5
<210> 141
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 141
Leu Leu Val Ser Lys
1 5
<210> 142
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 142
Leu Pro Asp Leu Lys
1 5
<210> 143
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 143
Leu Thr Leu Glu Gln Ala Val Lys
1 5
<210> 144
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 144
Leu Thr Trp Glu Gln Ala Val Lys
1 5
<210> 145
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 145
Leu Thr Trp Glu Gln Thr Val Lys
1 5
<210> 146
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 146
Leu Val Ala Trp Phe Val Gly Arg
1 5
<210> 147
<211> 11
<212> PRT
<213> RESISTANCE GENE
<400> 147
Leu Val Asn Trp Phe Ile Glu His Gly Tyr Arg
1 5 10
<210> 148
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 148
Leu Val Asn Trp Phe Val Glu Arg
1 5
<210> 149
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 149
Leu Val Thr Trp Phe Val Glu Arg
1 5
<210> 150
<211> 16
<212> PRT
<213> RESISTANCE GENE
<400> 150
Leu Val Val Pro Gly His Ser Glu Val Gly Asp Ala Ser Leu Leu Lys
1 5 10 15
<210> 151
<211> 16
<212> PRT
<213> RESISTANCE GENE
<400> 151
Leu Val Val Pro Ser His Ser Asp Ile Gly Asp Ala Ser Leu Leu Lys
1 5 10 15
<210> 152
<211> 16
<212> PRT
<213> RESISTANCE GENE
<400> 152
Leu Val Val Pro Ser His Ser Asp Ile Gly Asp Ser Ser Leu Leu Lys
1 5 10 15
<210> 153
<211> 16
<212> PRT
<213> RESISTANCE GENE
<400> 153
Leu Val Val Pro Ser His Ser Asp Val Gly Asp Ala Ser Leu Leu Lys
1 5 10 15
<210> 154
<211> 16
<212> PRT
<213> RESISTANCE GENE
<400> 154
Leu Val Val Pro Ser His Ser Glu Ala Gly Asp Ala Ser Leu Leu Lys
1 5 10 15
<210> 155
<211> 16
<212> PRT
<213> RESISTANCE GENE
<400> 155
Leu Val Val Pro Ser His Ser Glu Val Gly Asp Ala Ser Leu Leu Lys
1 5 10 15
<210> 156
<211> 16
<212> PRT
<213> RESISTANCE GENE
<400> 156
Leu Val Val Ser Gly His Ser Glu Ile Gly Asn Ala Ser Leu Leu Lys
1 5 10 15
<210> 157
<211> 16
<212> PRT
<213> RESISTANCE GENE
<400> 157
Leu Val Val Ser Gly His Ser Glu Thr Gly Asp Ala Thr His Leu Lys
1 5 10 15
<210> 158
<211> 16
<212> PRT
<213> RESISTANCE GENE
<400> 158
Leu Val Val Ser Ser His Ser Asp Ile Gly Asp Val Ser Leu Leu Lys
1 5 10 15
<210> 159
<211> 16
<212> PRT
<213> RESISTANCE GENE
<400> 159
Leu Val Val Ser Ser His Ser Glu Ile Gly Asp Ala Ser Leu Leu Lys
1 5 10 15
<210> 160
<211> 17
<212> PRT
<213> RESISTANCE GENE
<400> 160
Leu Val Val Ser Ser His Ser Glu Ile Gly Asn Ala Ser Leu Leu Gln
1 5 10 15
Arg
<210> 161
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 161
Leu Val Val Ser Ser His Ser Glu Lys
1 5
<210> 162
<211> 16
<212> PRT
<213> RESISTANCE GENE
<400> 162
Leu Val Val Ser Ser His Ser Glu Thr Gly Asn Ala Ser Leu Leu Lys
1 5 10 15
<210> 163
<211> 13
<212> PRT
<213> RESISTANCE GENE
<400> 163
Asn Asp Ala Tyr Leu Ile Asp Thr Pro Ile Thr Ala Lys
1 5 10
<210> 164
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 164
Asn Ser Phe Asp Gly Val Ser Tyr Trp Leu Ala Lys
1 5 10
<210> 165
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 165
Asn Ser Phe Gly Gly Val Asn Tyr Trp Leu Val Lys
1 5 10
<210> 166
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 166
Asn Ser Phe Ser Gly Ala Ser Tyr Trp Leu Val Lys
1 5 10
<210> 167
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 167
Asn Ser Phe Ser Gly Gly Ser Tyr Trp Leu Val Asn Asn Lys
1 5 10
<210> 168
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 168
Asn Ser Phe Ser Gly Val Ser Tyr Trp Leu Leu Lys
1 5 10
<210> 169
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 169
Asn Ser Phe Ser Gly Val Ser Tyr Trp Leu Val Lys
1 5 10
<210> 170
<211> 15
<212> PRT
<213> RESISTANCE GENE
<400> 170
Ser Ile Pro Thr Tyr Ala Ser Glu Leu Thr Asn Glu Leu Leu Lys
1 5 10 15
<210> 171
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 171
Thr Leu Glu Gln Ala Val Lys
1 5
<210> 172
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 172
Thr Trp Glu Gln Ala Leu Lys
1 5
<210> 173
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 173
Thr Trp Glu Gln Ala Val Lys
1 5
<210> 174
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 174
Val Leu Phe Gly Gly Cys Phe Val Lys
1 5
<210> 175
<211> 16
<212> PRT
<213> RESISTANCE GENE
<400> 175
Val Gln Ala Thr Asn Ser Phe Ser Gly Val Asn Tyr Trp Leu Val Lys
1 5 10 15
<210> 176
<211> 16
<212> PRT
<213> RESISTANCE GENE
<400> 176
Val Gln Ala Thr Asn Ser Phe Ser Gly Val Ser Tyr Ser Leu Ile Lys
1 5 10 15
<210> 177
<211> 16
<212> PRT
<213> RESISTANCE GENE
<400> 177
Val Gln Ala Thr Asn Ser Phe Ser Gly Val Ser Tyr Trp Leu Val Lys
1 5 10 15
<210> 178
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 178
Tyr Gly Asn Ala Lys
1 5
<210> 179
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 179
Tyr Ser Phe Ser Glu Val Ser Tyr Trp Leu Val Lys
1 5 10
<210> 180
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 180
Tyr Ser Phe Ser Gly Val Ser Tyr Trp Leu Val Lys
1 5 10
<210> 181
<211> 239
<212> PRT
<213> RESISTANCE GENE
<400> 181
Met Lys Lys Ser Ile Arg Phe Phe Ile Val Ser Ile Leu Leu Ser Pro
1 5 10 15
Phe Ala Ser Ala Gln Val Lys Asp Phe Val Ile Glu Pro Pro Ile Lys
20 25 30
Asn Asn Leu His Ile Tyr Lys Thr Phe Gly Val Phe Gly Gly Lys Glu
35 40 45
Tyr Ser Ala Asn Ser Met Tyr Leu Val Thr Lys Lys Gly Val Val Leu
50 55 60
Phe Asp Val Pro Trp Glu Lys Ile Gln Tyr Gln Ser Leu Met Asp Thr
65 70 75 80
Ile Lys Lys Arg His Asn Leu Pro Val Val Ala Val Phe Ala Thr His
85 90 95
Ser His Asp Asp Arg Ala Gly Asp Leu Ser Phe Phe Asn Asn Lys Gly
100 105 110
Ile Lys Thr Tyr Ala Thr Ala Lys Thr Asn Glu Phe Leu Lys Lys Asp
115 120 125
Gly Lys Ala Thr Ser Thr Glu Ile Ile Lys Thr Gly Lys Pro Tyr Arg
130 135 140
Ile Gly Gly Glu Glu Phe Val Val Asp Phe Leu Gly Glu Gly His Thr
145 150 155 160
Ala Asp Asn Val Val Val Trp Phe Pro Lys Tyr Asn Val Leu Asp Gly
165 170 175
Gly Cys Leu Val Lys Ser Asn Ser Ala Thr Asp Leu Gly Tyr Ile Lys
180 185 190
Glu Ala Asn Val Glu Gln Trp Pro Lys Thr Ile Asn Lys Leu Lys Ala
195 200 205
Lys Tyr Ser Lys Ala Thr Leu Ile Ile Pro Gly His Asp Glu Trp Lys
210 215 220
Gly Gly Gly His Val Glu His Thr Leu Glu Leu Leu Asn Lys Lys
225 230 235
<210> 182
<211> 243
<212> PRT
<213> RESISTANCE GENE
<400> 182
Met Lys Lys Ser Ile Gln Leu Leu Met Met Ser Met Phe Leu Ser Pro
1 5 10 15
Leu Ile Asn Ala Gln Val Lys Asp Phe Val Ile Glu Pro Pro Val Lys
20 25 30
Pro Asn Leu Tyr Leu Tyr Lys Ser Phe Gly Val Phe Gly Gly Lys Glu
35 40 45
Tyr Ser Ala Asn Ala Val Tyr Leu Thr Thr Lys Lys Gly Val Val Leu
50 55 60
Phe Asp Val Pro Trp Gln Lys Glu Gln Tyr Gln Thr Leu Met Asp Thr
65 70 75 80
Ile Gln Lys Arg His His Leu Pro Val Ile Ala Val Phe Ala Thr His
85 90 95
Ser His Asp Asp Arg Ala Gly Asp Leu Ser Phe Tyr Asn Gln Lys Gly
100 105 110
Ile Lys Thr Tyr Ala Thr Ala Lys Thr Asn Glu Leu Leu Lys Lys Asp
115 120 125
Gly Lys Ala Thr Ser Thr Glu Ile Ile Lys Thr Gly Lys Pro Tyr Lys
130 135 140
Ile Gly Gly Glu Glu Phe Met Val Asp Phe Leu Gly Glu Gly His Thr
145 150 155 160
Val Asp Asn Val Val Val Trp Phe Pro Lys Tyr Lys Val Leu Asp Gly
165 170 175
Gly Cys Leu Val Lys Ser Arg Thr Ala Thr Asp Leu Gly Tyr Thr Gly
180 185 190
Glu Ala Asn Val Lys Gln Trp Pro Glu Thr Met Arg Lys Leu Lys Thr
195 200 205
Lys Tyr Ala Gln Ala Thr Leu Val Ile Pro Gly His Asp Glu Trp Lys
210 215 220
Gly Gly Gly His Val Gln His Thr Leu Asp Leu Leu Asp Lys Asn Lys
225 230 235 240
Lys Pro Glu
<210> 183
<211> 243
<212> PRT
<213> RESISTANCE GENE
<400> 183
Met Lys Lys Ser Ile Gln Leu Leu Met Met Ser Met Phe Leu Ser Pro
1 5 10 15
Leu Ile Asn Ala Gln Val Lys Asp Phe Val Ile Glu Pro Pro Val Lys
20 25 30
Pro Asn Leu Tyr Leu Tyr Lys Ser Phe Gly Val Phe Gly Gly Lys Glu
35 40 45
Tyr Ser Ala Asn Ala Val Tyr Leu Thr Thr Lys Lys Gly Val Val Leu
50 55 60
Phe Asp Val Pro Trp Gln Lys Glu Gln Tyr Gln Thr Leu Met Asp Thr
65 70 75 80
Ile Gln Lys Arg His His Leu Pro Val Ile Ala Val Phe Ala Thr His
85 90 95
Ser His Asp Asp Arg Ala Gly Asp Leu Ser Phe Tyr Asn Gln Lys Gly
100 105 110
Ile Lys Thr Tyr Ala Thr Ala Lys Thr Asn Glu Leu Leu Lys Lys Asp
115 120 125
Gly Lys Ala Thr Ser Thr Glu Ile Ile Lys Thr Gly Lys Pro Tyr Lys
130 135 140
Ile Gly Gly Glu Glu Phe Met Val Asp Phe Leu Gly Glu Gly His Thr
145 150 155 160
Val Asp Asn Val Val Val Trp Phe Pro Lys Tyr Lys Val Leu Asp Gly
165 170 175
Gly Cys Leu Val Lys Ser Arg Thr Ala Thr Asp Leu Gly Tyr Thr Gly
180 185 190
Glu Ala Asn Val Lys Gln Trp Pro Glu Thr Met Arg Lys Leu Lys Thr
195 200 205
Lys Tyr Ala Gln Ala Thr Leu Val Ile Pro Gly His Glu Glu Trp Lys
210 215 220
Gly Gly Gly His Val Gln His Thr Leu Asp Leu Leu Asp Lys Asn Lys
225 230 235 240
Lys Pro Glu
<210> 184
<211> 239
<212> PRT
<213> RESISTANCE GENE
<400> 184
Met Lys Lys Arg Ile Gln Phe Phe Met Val Ser Met Met Leu Ser Ser
1 5 10 15
Leu Phe Ser Ala Gln Val Lys Asp Phe Val Ile Glu Pro Pro Ile Lys
20 25 30
Lys Asn Leu His Ile Tyr Lys Thr Phe Gly Val Phe Gly Gly Lys Glu
35 40 45
Tyr Ser Ala Asn Ser Val Tyr Leu Val Thr Gln Lys Gly Val Val Leu
50 55 60
Phe Asp Val Pro Trp Glu Lys Val Gln Tyr Gln Ser Leu Met Asp Thr
65 70 75 80
Ile Gln Lys Arg His Asn Leu Pro Val Ile Ala Val Phe Ala Thr His
85 90 95
Ser His Asp Asp Arg Ala Gly Asp Leu Ser Phe Phe Asn Asn Lys Gly
100 105 110
Ile Lys Thr Tyr Ala Thr Ser Lys Thr Asn Glu Phe Leu Lys Lys Asp
115 120 125
Gly Lys Ala Thr Ser Thr Glu Ile Ile Lys Thr Gly Lys Pro Tyr Arg
130 135 140
Ile Gly Gly Glu Glu Phe Val Val Asp Phe Leu Gly Glu Gly His Thr
145 150 155 160
Ala Asp Asn Val Val Val Trp Phe Pro Lys Tyr Asn Val Leu Asp Gly
165 170 175
Gly Cys Leu Val Lys Ser Lys Ala Ala Thr Asp Leu Gly Tyr Ile Lys
180 185 190
Glu Ala Asn Val Glu Gln Trp Pro Lys Thr Ile Asn Lys Leu Lys Ser
195 200 205
Lys Tyr Ser Lys Ala Ser Leu Val Ile Pro Gly His Asp Glu Trp Lys
210 215 220
Gly Gly Gly His Val Lys His Thr Leu Glu Leu Leu Asn Lys Lys
225 230 235
<210> 185
<211> 242
<212> PRT
<213> RESISTANCE GENE
<400> 185
Met Arg Lys Asn Val Arg Ile Phe Thr Val Leu Ser Leu Phe Leu Ile
1 5 10 15
Asn Phe Phe Asn Ala Gln Ala Arg Asp Phe Val Ile Glu Gln Pro Phe
20 25 30
Gly Lys Gln Leu Tyr Leu Tyr Lys Thr Phe Gly Val Phe Asp Gly Lys
35 40 45
Glu Tyr Ser Thr Asn Ala Leu Tyr Leu Val Thr Lys Lys Gly Val Val
50 55 60
Leu Phe Asp Val Pro Trp Gln Lys Thr Gln Tyr Gln Ser Leu Met Asp
65 70 75 80
Thr Ile Lys Lys Arg His Asn Leu Pro Val Ile Ala Val Phe Ala Thr
85 90 95
His Ser His Ser Asp Arg Ala Gly Asp Leu Ser Phe Tyr Asn Lys Lys
100 105 110
Gly Ile Pro Thr Tyr Ala Thr Ala Lys Thr Asn Glu Leu Leu Lys Lys
115 120 125
Glu Gly Lys Ala Thr Ser Ser Lys Leu Thr Lys Ile Gly Lys Lys Tyr
130 135 140
Lys Ile Gly Gly Glu Glu Phe Thr Val Asp Phe Leu Gly Glu Gly His
145 150 155 160
Thr Ala Asp Asn Val Val Val Trp Phe Pro Lys Tyr Asn Val Leu Asp
165 170 175
Gly Gly Cys Leu Val Lys Ser Ser Ala Ala Val Asp Leu Gly Tyr Thr
180 185 190
Gly Glu Ala Asn Val Glu Gln Trp Pro Ala Thr Met Lys Lys Leu Gln
195 200 205
Ala Lys Tyr Pro Ser Thr Ala Lys Val Ile Pro Gly His Asp Glu Trp
210 215 220
Lys Gly Asn Asp His Val Lys His Thr Leu Glu Leu Leu Asp Gln Gln
225 230 235 240
Lys Gln
<210> 186
<211> 239
<212> PRT
<213> RESISTANCE GENE
<400> 186
Met Lys Lys Arg Ile Gln Phe Phe Met Val Ser Met Met Leu Ala Pro
1 5 10 15
Met Phe Asn Ala Gln Val Lys Asp Phe Val Ile Glu Pro Pro Ile Lys
20 25 30
Asn Asn Leu His Ile Tyr Lys Thr Phe Gly Val Phe Gly Gly Lys Glu
35 40 45
Tyr Ser Ala Asn Ser Val Tyr Leu Val Thr Lys Lys Gly Val Val Leu
50 55 60
Phe Asp Val Pro Trp Glu Lys Ala Gln Tyr Gln Ser Leu Met Asp Thr
65 70 75 80
Ile Lys Lys Arg His Asn Leu Pro Val Ile Ala Val Phe Ala Thr His
85 90 95
Ser His Asp Asp Arg Ala Gly Asp Leu Ser Phe Phe Asn Asn Lys Gly
100 105 110
Ile Lys Thr Tyr Ala Thr Ser Lys Thr Asn Glu Phe Leu Lys Lys Asp
115 120 125
Gly Lys Ala Thr Ser Thr Glu Ile Ile Lys Thr Gly Lys Pro Tyr Arg
130 135 140
Ile Gly Gly Glu Glu Phe Thr Val Asp Phe Leu Gly Glu Gly His Thr
145 150 155 160
Ala Asp Asn Val Val Val Trp Phe Pro Lys Tyr Asn Val Leu Asp Gly
165 170 175
Gly Cys Leu Val Lys Ser Asn Ser Ala Thr Asp Leu Gly Tyr Ile Lys
180 185 190
Glu Ala Asn Val Glu Gln Trp Pro Ile Thr Ile Asp Lys Leu Lys Ala
195 200 205
Lys Tyr Ser Lys Ala Thr Leu Ile Ile Pro Gly His Asp Asp Trp Lys
210 215 220
Gly Gly Gly His Val Glu His Thr Leu Glu Leu Leu Asn Lys Lys
225 230 235
<210> 187
<211> 239
<212> PRT
<213> RESISTANCE GENE
<400> 187
Met Lys Arg Arg Ile Gln Phe Phe Met Val Ser Met Met Leu Thr Pro
1 5 10 15
Leu Phe Ser Ala Gln Val Lys Asp Phe Val Ile Glu Pro Pro Ile Lys
20 25 30
Lys Asn Leu Tyr Ile Tyr Lys Thr Phe Gly Val Phe Gly Gly Lys Glu
35 40 45
Tyr Ser Ala Asn Ser Val Tyr Leu Val Thr Lys Thr Gly Val Val Leu
50 55 60
Phe Asp Val Pro Trp Glu Lys Ala Gln Tyr Gln Ser Leu Met Asp Thr
65 70 75 80
Ile Lys Lys Arg His Asn Leu Pro Val Val Ala Val Phe Ala Thr His
85 90 95
Ser His Asp Asp Arg Ala Gly Asp Leu Ser Phe Phe Asn Asn Lys Gly
100 105 110
Ile Lys Thr Tyr Ala Thr Pro Lys Thr Asn Gln Phe Leu Lys Arg Asp
115 120 125
Gly Lys Ala Thr Ser Thr Glu Leu Ile Lys Pro Gly Lys Pro Tyr Arg
130 135 140
Phe Gly Gly Glu Glu Phe Val Val Asp Phe Leu Gly Glu Gly His Thr
145 150 155 160
Ala Asp Asn Val Val Val Trp Phe Pro Lys Tyr Lys Val Leu Asp Gly
165 170 175
Gly Cys Leu Val Lys Ser Asn Ser Ala Thr Asp Leu Gly Tyr Ile Lys
180 185 190
Glu Ala Asn Leu Glu Gln Trp Pro Lys Thr Met His Lys Leu Lys Thr
195 200 205
Lys Tyr Ser Glu Ala Val Leu Ile Ile Pro Gly His Asp Glu Trp Lys
210 215 220
Gly Gly Gly His Val Glu His Thr Leu Glu Leu Leu Asp Lys Lys
225 230 235
<210> 188
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 188
Ala Ala Thr Asp Leu Gly Tyr Ile Lys
1 5
<210> 189
<211> 10
<212> PRT
<213> RESISTANCE GENE
<400> 189
Ala Gly Asp Leu Ser Phe Phe Asn Asn Lys
1 5 10
<210> 190
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 190
Ala Gly Asp Leu Ser Phe Tyr Asn Lys
1 5
<210> 191
<211> 10
<212> PRT
<213> RESISTANCE GENE
<400> 191
Ala Gly Asp Leu Ser Phe Tyr Asn Gln Lys
1 5 10
<210> 192
<211> 11
<212> PRT
<213> RESISTANCE GENE
<400> 192
Ala Gln Tyr Gln Ser Leu Met Asp Thr Ile Lys
1 5 10
<210> 193
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 193
Ala Ser Leu Val Ile Pro Gly His Asp Glu Trp Lys
1 5 10
<210> 194
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 194
Ala Thr Leu Ile Ile Pro Gly His Asp Asp Trp Lys
1 5 10
<210> 195
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 195
Ala Thr Leu Ile Ile Pro Gly His Asp Glu Trp Lys
1 5 10
<210> 196
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 196
Ala Thr Ser Ser Lys
1 5
<210> 197
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 197
Ala Thr Ser Thr Glu Ile Ile Lys
1 5
<210> 198
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 198
Ala Thr Ser Thr Glu Leu Ile Lys
1 5
<210> 199
<211> 11
<212> PRT
<213> RESISTANCE GENE
<400> 199
Ala Thr Ser Thr Glu Leu Ile Lys Pro Gly Lys
1 5 10
<210> 200
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 200
Ala Thr Ser Thr Glu Leu Ile Lys Pro Gly Lys Pro Tyr Arg
1 5 10
<210> 201
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 201
Asp Phe Val Ile Glu Pro Pro Ile Lys
1 5
<210> 202
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 202
Asp Phe Val Ile Glu Pro Pro Val Lys
1 5
<210> 203
<211> 16
<212> PRT
<213> RESISTANCE GENE
<400> 203
Asp Phe Val Ile Glu Pro Pro Val Lys Pro Asn Leu Tyr Leu Tyr Lys
1 5 10 15
<210> 204
<211> 10
<212> PRT
<213> RESISTANCE GENE
<400> 204
Asp Phe Val Ile Glu Gln Pro Phe Gly Lys
1 5 10
<210> 205
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 205
Glu Ala Asn Leu Glu Gln Trp Pro Lys
1 5
<210> 206
<211> 13
<212> PRT
<213> RESISTANCE GENE
<400> 206
Glu Ala Asn Val Glu Gln Trp Pro Ile Thr Ile Asp Lys
1 5 10
<210> 207
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 207
Glu Ala Asn Val Glu Gln Trp Pro Lys
1 5
<210> 208
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 208
Glu Gln Tyr Gln Thr Leu Met Asp Thr Ile Gln Lys
1 5 10
<210> 209
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 209
Glu Tyr Ser Ala Asn Ala Val Tyr Leu Thr Thr Lys
1 5 10
<210> 210
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 210
Glu Tyr Ser Ala Asn Ser Met Tyr Leu Val Thr Lys
1 5 10
<210> 211
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 211
Glu Tyr Ser Ala Asn Ser Val Tyr Leu Val Thr Lys
1 5 10
<210> 212
<211> 13
<212> PRT
<213> RESISTANCE GENE
<400> 212
Glu Tyr Ser Ala Asn Ser Val Tyr Leu Val Thr Gln Lys
1 5 10
<210> 213
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 213
Glu Tyr Ser Thr Asn Ala Leu Tyr Leu Val Thr Lys
1 5 10
<210> 214
<211> 17
<212> PRT
<213> RESISTANCE GENE
<400> 214
Phe Phe Ile Val Ser Ile Leu Leu Ser Pro Phe Ala Ser Ala Gln Val
1 5 10 15
Lys
<210> 215
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 215
Gly Gly Gly His Val Glu His Thr Leu Glu Leu Leu Asp Lys
1 5 10
<210> 216
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 216
Gly Gly Gly His Val Glu His Thr Leu Glu Leu Leu Asn Lys
1 5 10
<210> 217
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 217
Gly Gly Gly His Val Lys
1 5
<210> 218
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 218
Gly Gly Gly His Val Gln His Thr Leu Asp Leu Leu Asp Lys
1 5 10
<210> 219
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 219
Gly Ile Pro Thr Tyr Ala Thr Ala Lys
1 5
<210> 220
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 220
Gly Asn Asp His Val Lys
1 5
<210> 221
<211> 11
<212> PRT
<213> RESISTANCE GENE
<400> 221
Gly Val Val Leu Phe Asp Val Pro Trp Glu Lys
1 5 10
<210> 222
<211> 11
<212> PRT
<213> RESISTANCE GENE
<400> 222
Gly Val Val Leu Phe Asp Val Pro Trp Gln Lys
1 5 10
<210> 223
<211> 17
<212> PRT
<213> RESISTANCE GENE
<400> 223
His His Leu Pro Val Ile Ala Val Phe Ala Thr His Ser His Asp Asp
1 5 10 15
Arg
<210> 224
<211> 17
<212> PRT
<213> RESISTANCE GENE
<400> 224
His Asn Leu Pro Val Ile Ala Val Phe Ala Thr His Ser His Asp Asp
1 5 10 15
Arg
<210> 225
<211> 17
<212> PRT
<213> RESISTANCE GENE
<400> 225
His Asn Leu Pro Val Ile Ala Val Phe Ala Thr His Ser His Ser Asp
1 5 10 15
Arg
<210> 226
<211> 17
<212> PRT
<213> RESISTANCE GENE
<400> 226
His Asn Leu Pro Val Val Ala Val Phe Ala Thr His Ser His Asp Asp
1 5 10 15
Arg
<210> 227
<211> 10
<212> PRT
<213> RESISTANCE GENE
<400> 227
His Thr Leu Glu Leu Leu Asp Gln Gln Lys
1 5 10
<210> 228
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 228
His Thr Leu Glu Leu Leu Asn Lys
1 5
<210> 229
<211> 18
<212> PRT
<213> RESISTANCE GENE
<400> 229
Ile Phe Thr Val Leu Ser Leu Phe Leu Ile Asn Phe Phe Asn Ala Gln
1 5 10 15
Ala Arg
<210> 230
<211> 19
<212> PRT
<213> RESISTANCE GENE
<400> 230
Ile Gln Phe Phe Met Val Ser Met Met Leu Ala Pro Met Phe Asn Ala
1 5 10 15
Gln Val Lys
<210> 231
<211> 19
<212> PRT
<213> RESISTANCE GENE
<400> 231
Ile Gln Phe Phe Met Val Ser Met Met Leu Ser Ser Leu Phe Ser Ala
1 5 10 15
Gln Val Lys
<210> 232
<211> 19
<212> PRT
<213> RESISTANCE GENE
<400> 232
Ile Gln Phe Phe Met Val Ser Met Met Leu Thr Pro Leu Phe Ser Ala
1 5 10 15
Gln Val Lys
<210> 233
<211> 11
<212> PRT
<213> RESISTANCE GENE
<400> 233
Ile Gln Tyr Gln Ser Leu Met Asp Thr Ile Lys
1 5 10
<210> 234
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 234
Asn Leu His Ile Tyr Lys
1 5
<210> 235
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 235
Asn Leu Tyr Ile Tyr Lys
1 5
<210> 236
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 236
Asn Asn Leu His Ile Tyr Lys
1 5
<210> 237
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 237
Gln Leu Tyr Leu Tyr Lys
1 5
<210> 238
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 238
Gln Trp Pro Glu Thr Met Arg
1 5
<210> 239
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 239
Ser Phe Gly Val Phe Gly Gly Lys
1 5
<210> 240
<211> 20
<212> PRT
<213> RESISTANCE GENE
<400> 240
Ser Ile Gln Leu Leu Met Met Ser Met Phe Leu Ser Pro Leu Ile Asn
1 5 10 15
Ala Gln Val Lys
20
<210> 241
<211> 11
<212> PRT
<213> RESISTANCE GENE
<400> 241
Ser Asn Ser Ala Thr Asp Leu Gly Tyr Ile Lys
1 5 10
<210> 242
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 242
Thr Ala Thr Asp Leu Gly Tyr Thr Gly Glu Ala Asn Val Lys
1 5 10
<210> 243
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 243
Thr Phe Gly Val Phe Asp Gly Lys
1 5
<210> 244
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 244
Thr Phe Gly Val Phe Gly Gly Lys
1 5
<210> 245
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 245
Thr Gly Lys Pro Tyr Lys
1 5
<210> 246
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 246
Thr Gly Lys Pro Tyr Arg
1 5
<210> 247
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 247
Thr Gly Val Val Leu Phe Asp Val Pro Trp Glu Lys
1 5 10
<210> 248
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 248
Thr Asn Glu Phe Leu Lys
1 5
<210> 249
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 249
Thr Asn Glu Leu Leu Lys
1 5
<210> 250
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 250
Thr Asn Gln Phe Leu Lys
1 5
<210> 251
<211> 11
<212> PRT
<213> RESISTANCE GENE
<400> 251
Thr Gln Tyr Gln Ser Leu Met Asp Thr Ile Lys
1 5 10
<210> 252
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 252
Thr Tyr Ala Thr Ala Lys
1 5
<210> 253
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 253
Thr Tyr Ala Thr Pro Lys
1 5
<210> 254
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 254
Thr Tyr Ala Thr Ser Lys
1 5
<210> 255
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 255
Val Ile Pro Gly His Asp Glu Trp Lys
1 5
<210> 256
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 256
Val Leu Asp Gly Gly Cys Leu Val Lys
1 5
<210> 257
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 257
Val Gln Tyr Gln Ser Leu Met Asp Thr Ile Gln Lys
1 5 10
<210> 258
<211> 15
<212> PRT
<213> RESISTANCE GENE
<400> 258
Tyr Ala Gln Ala Thr Leu Val Ile Pro Gly His Asp Glu Trp Lys
1 5 10 15
<210> 259
<211> 15
<212> PRT
<213> RESISTANCE GENE
<400> 259
Tyr Ala Gln Ala Thr Leu Val Ile Pro Gly His Glu Glu Trp Lys
1 5 10 15
<210> 260
<211> 11
<212> PRT
<213> RESISTANCE GENE
<400> 260
Tyr Asn Val Leu Asp Gly Gly Cys Leu Val Lys
1 5 10
<210> 261
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 261
Tyr Pro Ser Thr Ala Lys
1 5
<210> 262
<211> 15
<212> PRT
<213> RESISTANCE GENE
<400> 262
Tyr Ser Glu Ala Val Leu Ile Ile Pro Gly His Asp Glu Trp Lys
1 5 10 15
<210> 263
<211> 294
<212> PRT
<213> RESISTANCE GENE
<400> 263
Met Ser Asn Lys Val Asn Phe Lys Thr Ala Ser Phe Leu Phe Ser Val
1 5 10 15
Cys Leu Ala Leu Ser Ala Phe Asn Ala His Ala Asn Lys Ser Asp Ala
20 25 30
Ala Ala Lys Gln Ile Lys Lys Leu Glu Glu Asp Phe Asp Gly Arg Ile
35 40 45
Gly Val Phe Ala Ile Asp Thr Gly Ser Gly Asn Thr Phe Gly Tyr Arg
50 55 60
Ser Asp Glu Arg Phe Pro Leu Cys Ser Ser Phe Lys Gly Phe Leu Ala
65 70 75 80
Ala Ala Val Leu Glu Arg Val Gln Gln Lys Lys Leu Asp Ile Asn Gln
85 90 95
Lys Val Lys Tyr Glu Ser Arg Asp Leu Glu Tyr His Ser Pro Ile Thr
100 105 110
Thr Lys Tyr Lys Gly Ser Gly Met Thr Leu Gly Asp Met Ala Ser Ala
115 120 125
Ala Leu Gln Tyr Ser Asp Asn Gly Ala Thr Asn Ile Ile Met Glu Arg
130 135 140
Phe Leu Gly Gly Pro Glu Gly Met Thr Lys Phe Met Arg Ser Ile Gly
145 150 155 160
Asp Asn Glu Phe Arg Leu Asp Arg Trp Glu Leu Glu Leu Asn Thr Ala
165 170 175
Ile Pro Gly Asp Lys Arg Asp Thr Ser Thr Pro Lys Ala Val Ala Asn
180 185 190
Ser Leu Asn Lys Leu Ala Leu Gly Asn Val Leu Asn Ala Lys Glu Lys
195 200 205
Ala Ile Tyr Gln Asn Trp Leu Lys Gly Asn Thr Thr Gly Asp Ala Arg
210 215 220
Ile Arg Ala Ser Val Pro Ala Asp Trp Val Val Gly Asp Lys Thr Gly
225 230 235 240
Ser Cys Gly Ala Tyr Gly Thr Ala Asn Asp Tyr Ala Val Ile Trp Pro
245 250 255
Lys Asn Arg Ala Pro Leu Ile Val Ser Ile Tyr Thr Thr Arg Lys Ser
260 265 270
Lys Asp Asp Lys His Ser Asp Lys Thr Ile Ala Glu Ala Ser Arg Ile
275 280 285
Ala Ile Gln Ala Ile Asp
290
<210> 264
<211> 294
<212> PRT
<213> RESISTANCE GENE
<400> 264
Met Ser Asn Lys Val Asn Phe Lys Thr Ala Ser Phe Leu Phe Ser Val
1 5 10 15
Cys Leu Ala Leu Ser Ala Phe Asn Ala His Ala Asn Lys Ser Asp Ala
20 25 30
Ala Ala Lys Gln Ile Lys Lys Leu Glu Glu Asp Phe Asp Gly Arg Ile
35 40 45
Gly Val Phe Ala Ile Asp Thr Gly Ser Gly Asn Thr Phe Gly Tyr Arg
50 55 60
Ser Asp Glu Arg Phe Pro Leu Cys Ser Ser Phe Lys Gly Phe Leu Ala
65 70 75 80
Ala Ala Val Leu Glu Arg Val Gln Gln Lys Lys Leu Asp Ile Asn Gln
85 90 95
Lys Val Lys Tyr Glu Ser Arg Asp Leu Glu Tyr Tyr Ser Pro Ile Thr
100 105 110
Thr Lys Tyr Lys Gly Ser Gly Met Thr Leu Gly Asp Met Ala Ser Ala
115 120 125
Ala Leu Gln Tyr Ser Asp Asn Gly Ala Thr Asn Ile Ile Met Glu Arg
130 135 140
Phe Leu Gly Gly Pro Glu Gly Met Thr Lys Phe Met Arg Ser Ile Gly
145 150 155 160
Asp Asn Glu Phe Arg Leu Asp Arg Trp Glu Leu Glu Leu Asn Thr Ala
165 170 175
Ile Pro Gly Asp Lys Arg Asp Thr Ser Thr Pro Lys Ala Val Ala Asn
180 185 190
Ser Leu Asn Lys Leu Ala Leu Gly Asn Val Leu Asn Ala Lys Val Lys
195 200 205
Ala Ile Tyr Gln Asn Trp Leu Lys Gly Asn Thr Thr Gly Asp Ala Arg
210 215 220
Ile Arg Ala Ser Val Pro Ala Asp Trp Val Val Gly Asp Lys Thr Gly
225 230 235 240
Ser Cys Gly Ala Tyr Gly Thr Ala Asn Asp Tyr Ala Val Ile Trp Pro
245 250 255
Lys Asn Arg Ala Pro Leu Ile Val Ser Ile Tyr Thr Thr Arg Lys Ser
260 265 270
Lys Asp Asp Lys His Ser Asp Lys Thr Ile Ala Glu Ala Ser Arg Ile
275 280 285
Ala Ile Gln Ala Ile Asp
290
<210> 265
<211> 294
<212> PRT
<213> RESISTANCE GENE
<400> 265
Met Ser Asn Lys Val Asn Phe Lys Thr Ala Ser Phe Leu Phe Ser Val
1 5 10 15
Cys Leu Ala Leu Ser Ala Phe Asn Ala His Ala Asn Lys Ser Asp Ala
20 25 30
Ala Ala Lys Gln Ile Lys Lys Leu Glu Glu Asp Phe Asp Gly Arg Ile
35 40 45
Gly Val Phe Ala Ile Asp Thr Gly Ser Gly Asn Thr Phe Gly Tyr Arg
50 55 60
Ser Asp Glu Arg Phe Pro Leu Cys Ser Ser Phe Lys Gly Phe Leu Ala
65 70 75 80
Ala Ala Val Leu Glu Arg Val Gln Gln Lys Lys Leu Asp Ile Asn Gln
85 90 95
Lys Val Lys Tyr Glu Ser Arg Asp Leu Glu Tyr His Ser Pro Ile Thr
100 105 110
Thr Lys Tyr Lys Gly Ser Gly Met Thr Leu Gly Asp Met Ala Ser Ala
115 120 125
Ala Leu Gln Tyr Ser Asp Asn Gly Ala Thr Asn Ile Ile Met Glu Arg
130 135 140
Phe Leu Gly Gly Pro Glu Gly Met Thr Lys Phe Met Arg Ser Ile Gly
145 150 155 160
Asp Asn Glu Phe Arg Leu Asp Arg Trp Glu Leu Glu Leu Asn Thr Ala
165 170 175
Ile Pro Gly Asp Lys Arg Asp Thr Ser Thr Pro Lys Ala Val Ala Asn
180 185 190
Ser Leu Asn Lys Leu Ala Leu Gly Asn Val Leu Asn Ala Lys Val Lys
195 200 205
Ala Ile Tyr Gln Asn Trp Leu Lys Gly Asn Thr Thr Gly Asp Ala Arg
210 215 220
Ile Arg Ala Ser Val Pro Ala Asp Trp Val Val Gly Asp Lys Thr Gly
225 230 235 240
Ser Cys Gly Ala Ile Gly Thr Ala Asn Asp Tyr Ala Val Ile Trp Pro
245 250 255
Lys Asn Arg Ala Pro Leu Ile Val Ser Ile Tyr Thr Thr Arg Lys Ser
260 265 270
Lys Asp Asp Lys His Ser Asp Lys Thr Ile Ala Glu Ala Ser Arg Ile
275 280 285
Ala Ile Gln Ala Ile Asp
290
<210> 266
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 266
Ala Ile Tyr Gln Asn Trp Leu Lys
1 5
<210> 267
<211> 11
<212> PRT
<213> RESISTANCE GENE
<400> 267
Ala Pro Leu Ile Val Ser Ile Tyr Thr Thr Arg
1 5 10
<210> 268
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 268
Ala Ser Val Pro Ala Asp Trp Val Val Gly Asp Lys
1 5 10
<210> 269
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 269
Ala Val Ala Asn Ser Leu Asn Lys
1 5
<210> 270
<211> 11
<212> PRT
<213> RESISTANCE GENE
<400> 270
Asp Leu Glu Tyr His Ser Pro Ile Thr Thr Lys
1 5 10
<210> 271
<211> 11
<212> PRT
<213> RESISTANCE GENE
<400> 271
Asp Leu Glu Tyr Tyr Ser Pro Ile Thr Thr Lys
1 5 10
<210> 272
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 272
Asp Thr Ser Thr Pro Lys
1 5
<210> 273
<211> 10
<212> PRT
<213> RESISTANCE GENE
<400> 273
Phe Leu Gly Gly Pro Glu Gly Met Thr Lys
1 5 10
<210> 274
<211> 10
<212> PRT
<213> RESISTANCE GENE
<400> 274
Gly Phe Leu Ala Ala Ala Val Leu Glu Arg
1 5 10
<210> 275
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 275
Gly Asn Thr Thr Gly Asp Ala Arg
1 5
<210> 276
<211> 17
<212> PRT
<213> RESISTANCE GENE
<400> 276
Ile Gly Val Phe Ala Ile Asp Thr Gly Ser Gly Asn Thr Phe Gly Tyr
1 5 10 15
Arg
<210> 277
<211> 10
<212> PRT
<213> RESISTANCE GENE
<400> 277
Leu Ala Leu Gly Asn Val Leu Asn Ala Lys
1 5 10
<210> 278
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 278
Leu Asp Ile Asn Gln Lys
1 5
<210> 279
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 279
Leu Glu Glu Asp Phe Asp Gly Arg
1 5
<210> 280
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 280
Ser Asp Ala Ala Ala Lys
1 5
<210> 281
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 281
Ser Ile Gly Asp Asn Glu Phe Arg
1 5
<210> 282
<211> 21
<212> PRT
<213> RESISTANCE GENE
<400> 282
Thr Ala Ser Phe Leu Phe Ser Val Cys Leu Ala Leu Ser Ala Phe Asn
1 5 10 15
Ala His Ala Asn Lys
20
<210> 283
<211> 19
<212> PRT
<213> RESISTANCE GENE
<400> 283
Thr Gly Ser Cys Gly Ala Ile Gly Thr Ala Asn Asp Tyr Ala Val Ile
1 5 10 15
Trp Pro Lys
<210> 284
<211> 19
<212> PRT
<213> RESISTANCE GENE
<400> 284
Thr Gly Ser Cys Gly Ala Tyr Gly Thr Ala Asn Asp Tyr Ala Val Ile
1 5 10 15
Trp Pro Lys
<210> 285
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 285
Thr Ile Ala Glu Ala Ser Arg
1 5
<210> 286
<211> 13
<212> PRT
<213> RESISTANCE GENE
<400> 286
Trp Glu Leu Glu Leu Asn Thr Ala Ile Pro Gly Asp Lys
1 5 10
<210> 287
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 287
Phe Pro Leu Cys Ser Ser Phe Lys
1 5
<210> 288
<211> 266
<212> PRT
<213> RESISTANCE GENE
<400> 288
Met Phe Lys Leu Leu Ser Lys Leu Leu Val Tyr Leu Thr Ala Ser Ile
1 5 10 15
Met Ala Ile Ala Ser Pro Leu Ala Phe Ser Val Asp Ser Ser Gly Glu
20 25 30
Tyr Pro Thr Val Ser Glu Ile Pro Val Gly Glu Val Arg Leu Tyr Gln
35 40 45
Ile Ala Asp Gly Val Trp Ser His Ile Ala Thr Gln Ser Phe Asp Gly
50 55 60
Ala Val Tyr Pro Ser Asn Gly Leu Ile Val Arg Asp Gly Asp Glu Leu
65 70 75 80
Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys Asn Thr Ala Ala Leu Leu
85 90 95
Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro Val Thr Arg Ala Val Ser
100 105 110
Thr His Phe His Asp Asp Arg Val Gly Gly Val Asp Val Leu Arg Ala
115 120 125
Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser Thr Arg Arg Leu Ala Glu
130 135 140
Val Glu Gly Asn Glu Ile Pro Thr His Ser Leu Glu Gly Leu Ser Ser
145 150 155 160
Ser Gly Asp Ala Val Arg Phe Gly Pro Val Glu Leu Phe Tyr Pro Gly
165 170 175
Ala Ala His Ser Thr Asp Asn Leu Val Val Tyr Val Pro Ser Ala Ser
180 185 190
Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu Leu Ser Arg Thr Ser Ala
195 200 205
Gly Asn Val Ala Asp Ala Asp Leu Ala Glu Trp Pro Thr Ser Ile Glu
210 215 220
Arg Ile Gln Gln His Tyr Pro Glu Ala Gln Phe Val Ile Pro Gly His
225 230 235 240
Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys His Thr Thr Asn Val Val
245 250 255
Lys Ala His Thr Asn Arg Ser Val Val Glu
260 265
<210> 289
<211> 266
<212> PRT
<213> RESISTANCE GENE
<400> 289
Met Phe Lys Leu Leu Ser Lys Leu Leu Val Tyr Leu Thr Ala Ser Ile
1 5 10 15
Met Ala Ile Ala Ser Pro Leu Ala Phe Ser Val Asp Ser Ser Gly Glu
20 25 30
Tyr Pro Thr Val Ser Glu Ile Pro Val Gly Glu Val Arg Leu Tyr Gln
35 40 45
Ile Ala Asp Gly Val Trp Ser His Ile Ala Thr Lys Ser Phe Asp Gly
50 55 60
Ala Val Tyr Pro Ser Asn Gly Leu Ile Val Arg Asp Gly Asp Glu Leu
65 70 75 80
Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys Asn Thr Ala Ala Leu Leu
85 90 95
Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro Val Thr Arg Ala Val Ser
100 105 110
Thr His Phe His Asp Asp Arg Val Gly Gly Val Asp Val Leu Arg Ala
115 120 125
Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser Thr Arg Arg Leu Ala Glu
130 135 140
Val Glu Gly Ser Glu Ile Pro Thr His Ser Leu Glu Gly Leu Ser Ser
145 150 155 160
Ser Gly Asp Ala Val Arg Phe Gly Pro Val Glu Leu Phe Tyr Pro Gly
165 170 175
Ala Ala His Ser Thr Asp Asn Leu Val Val Tyr Val Pro Ser Ala Ser
180 185 190
Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu Leu Ser Arg Thr Ser Ala
195 200 205
Gly Asn Val Ala Asp Ala Asp Leu Ala Glu Trp Pro Thr Ser Ile Glu
210 215 220
Arg Ile Gln Gln His Tyr Pro Glu Ala Gln Phe Val Ile Pro Gly His
225 230 235 240
Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys His Thr Thr Asn Val Val
245 250 255
Lys Ala His Thr Asn Arg Ser Val Val Glu
260 265
<210> 290
<211> 266
<212> PRT
<213> RESISTANCE GENE
<400> 290
Met Leu Lys Val Ile Ser Ser Leu Leu Val Tyr Met Thr Ala Ser Val
1 5 10 15
Met Ala Val Ala Ser Pro Leu Ala His Ser Gly Glu Pro Ser Gly Glu
20 25 30
Tyr Pro Thr Val Asn Glu Ile Pro Val Gly Glu Val Arg Leu Tyr Gln
35 40 45
Ile Ala Asp Gly Val Trp Ser His Ile Ala Thr Gln Ser Phe Asp Gly
50 55 60
Ala Val Tyr Pro Ser Asn Gly Leu Ile Val Arg Asp Gly Asp Glu Leu
65 70 75 80
Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys Asn Thr Ala Ala Leu Leu
85 90 95
Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro Val Thr Arg Ala Val Ser
100 105 110
Thr His Phe His Asp Asp Arg Val Gly Gly Val Asp Val Leu Arg Ala
115 120 125
Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser Thr Arg Arg Leu Ala Glu
130 135 140
Ala Glu Gly Asn Glu Ile Pro Thr His Ser Leu Glu Gly Leu Ser Ser
145 150 155 160
Ser Gly Asp Ala Val Arg Phe Gly Pro Val Glu Leu Phe Tyr Pro Gly
165 170 175
Ala Ala His Ser Thr Asp Asn Leu Val Val Tyr Val Pro Ser Ala Asn
180 185 190
Val Leu Tyr Gly Gly Cys Ala Val His Glu Leu Ser Arg Thr Ser Ala
195 200 205
Gly Asn Val Ala Asp Ala Asp Leu Ala Glu Trp Pro Thr Ser Val Glu
210 215 220
Arg Ile Gln Lys His Tyr Pro Glu Ala Glu Val Val Ile Pro Gly His
225 230 235 240
Gly Leu Pro Gly Gly Leu Asp Leu Leu Gln His Thr Ala Asn Val Val
245 250 255
Lys Ala His Lys Asn Arg Ser Val Ala Glu
260 265
<210> 291
<211> 266
<212> PRT
<213> RESISTANCE GENE
<400> 291
Met Leu Lys Val Ile Ser Ser Leu Leu Val Tyr Met Thr Ala Ser Val
1 5 10 15
Met Ala Val Ala Ser Pro Leu Ala His Ser Gly Glu Pro Ser Gly Glu
20 25 30
Tyr Pro Thr Val Asn Glu Ile Pro Val Gly Glu Val Arg Leu Tyr Gln
35 40 45
Ile Ala Asp Gly Val Trp Ser His Ile Ala Thr Gln Ser Phe Asp Gly
50 55 60
Ala Val Tyr Pro Ser Asn Gly Leu Ile Val Arg Asp Gly Asp Glu Leu
65 70 75 80
Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys Asn Thr Ala Ala Leu Leu
85 90 95
Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro Val Thr Arg Ala Val Ser
100 105 110
Thr His Phe His Asp Asp Arg Val Gly Gly Val Asp Val Leu Arg Lys
115 120 125
Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser Thr Arg Arg Leu Ala Glu
130 135 140
Ala Glu Gly Asn Glu Ile Pro Thr His Ser Leu Glu Gly Leu Ser Ser
145 150 155 160
Ser Gly Asp Ala Val Arg Phe Gly Pro Val Glu Leu Phe Tyr Pro Gly
165 170 175
Ala Ala His Ser Thr Asp Asn Leu Val Val Tyr Val Pro Ser Ala Asn
180 185 190
Val Leu Tyr Gly Gly Cys Ala Val Leu Ala Leu Ser Arg Thr Ser Ala
195 200 205
Gly Asn Val Ala Asp Ala Asp Leu Ala Glu Trp Pro Thr Ser Val Glu
210 215 220
Arg Ile Gln Lys His Tyr Pro Glu Ala Glu Val Val Ile Pro Gly His
225 230 235 240
Gly Leu Pro Gly Gly Leu Asp Leu Leu Gln His Thr Ala Asn Val Val
245 250 255
Thr Ala His Lys Asn Arg Ser Val Ala Glu
260 265
<210> 292
<211> 266
<212> PRT
<213> RESISTANCE GENE
<400> 292
Met Phe Lys Leu Leu Ser Lys Leu Leu Val Tyr Leu Thr Ala Ser Ile
1 5 10 15
Met Ala Ile Ala Ser Pro Leu Ala Phe Ser Val Asp Ser Ser Gly Glu
20 25 30
Tyr Pro Thr Val Ser Glu Ile Pro Val Gly Glu Val Arg Leu Tyr Gln
35 40 45
Ile Ala Asp Gly Val Trp Ser His Ile Ala Thr Arg Ser Phe Asp Gly
50 55 60
Ala Val Tyr Pro Ser Asn Gly Leu Ile Val Arg Asp Gly Asp Glu Leu
65 70 75 80
Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys Asn Thr Ala Ala Leu Leu
85 90 95
Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro Val Thr Arg Ala Val Ser
100 105 110
Thr His Phe His Asp Asp Arg Val Gly Gly Val Asp Val Leu Arg Ala
115 120 125
Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser Thr Arg Arg Leu Ala Glu
130 135 140
Val Glu Gly Ser Glu Ile Pro Thr His Ser Leu Glu Gly Leu Ser Ser
145 150 155 160
Ser Gly Asp Ala Val Arg Phe Gly Pro Val Glu Leu Phe Tyr Pro Gly
165 170 175
Ala Ala His Ser Thr Asp Asn Leu Val Val Tyr Val Pro Ser Ala Ser
180 185 190
Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu Leu Ser Arg Thr Ser Ala
195 200 205
Gly Asn Val Ala Asp Ala Asp Leu Ala Glu Trp Pro Thr Ser Ile Glu
210 215 220
Arg Ile Gln Gln His Tyr Pro Glu Ala Gln Phe Val Ile Pro Gly His
225 230 235 240
Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys His Thr Thr Asn Val Val
245 250 255
Lys Ala His Thr Asn Arg Ser Val Val Glu
260 265
<210> 293
<211> 266
<212> PRT
<213> RESISTANCE GENE
<400> 293
Met Phe Lys Leu Leu Ser Lys Leu Leu Val Tyr Leu Thr Ala Ser Ile
1 5 10 15
Met Ala Ile Ala Ser Pro Leu Ala Phe Ser Val Asp Ser Ser Gly Glu
20 25 30
Tyr Pro Thr Val Ser Glu Ile Pro Val Gly Glu Val Arg Leu Tyr Gln
35 40 45
Ile Ala Asp Gly Val Trp Ser His Ile Ala Thr Gln Ser Phe Asp Gly
50 55 60
Ala Val Tyr Pro Ser Asn Gly Leu Ile Val Arg Asp Gly Asp Glu Leu
65 70 75 80
Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys Asn Thr Ala Ala Leu Leu
85 90 95
Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro Val Thr Arg Ala Val Ser
100 105 110
Thr His Phe His Asp Asp Arg Val Gly Gly Val Asp Val Leu Arg Ala
115 120 125
Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser Ala Arg Arg Leu Ala Glu
130 135 140
Val Glu Gly Asn Glu Ile Pro Thr His Ser Leu Glu Gly Leu Ser Ser
145 150 155 160
Ser Gly Asp Ala Val Arg Phe Gly Pro Val Glu Leu Phe Tyr Pro Gly
165 170 175
Ala Ala His Ser Thr Asp Asn Leu Val Val Tyr Val Pro Ser Ala Ser
180 185 190
Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu Leu Ser Arg Thr Ser Ala
195 200 205
Gly Asn Val Ala Asp Ala Asp Leu Ala Glu Trp Pro Thr Ser Ile Glu
210 215 220
Arg Ile Gln Gln His Tyr Pro Glu Ala Gln Phe Val Ile Pro Gly His
225 230 235 240
Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys His Thr Thr Asn Val Val
245 250 255
Lys Ala His Thr Asn Arg Ser Val Val Glu
260 265
<210> 294
<211> 266
<212> PRT
<213> RESISTANCE GENE
<400> 294
Met Phe Lys Leu Leu Ser Lys Leu Leu Val Tyr Leu Thr Ala Ser Ile
1 5 10 15
Met Ala Ile Ala Ser Pro Leu Ala Phe Ser Val Asp Ser Ser Gly Glu
20 25 30
Tyr Pro Thr Val Ser Glu Ile Pro Val Gly Glu Val Arg Leu Tyr Gln
35 40 45
Ile Ala Asp Gly Val Trp Ser His Ile Ala Thr Gln Ser Phe Asp Gly
50 55 60
Ala Val Tyr Pro Ser Asn Gly Leu Ile Val Arg Asp Gly Asp Glu Leu
65 70 75 80
Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys Asn Thr Ala Ala Leu Leu
85 90 95
Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro Val Thr Arg Ala Val Ser
100 105 110
Thr His Phe His Asp Asp Arg Val Gly Gly Val Asp Val Leu Arg Ala
115 120 125
Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser Ile Arg Arg Leu Ala Glu
130 135 140
Val Glu Gly Asn Glu Ile Pro Thr His Ser Leu Glu Gly Leu Ser Ser
145 150 155 160
Ser Gly Asp Ala Val Arg Phe Gly Pro Val Glu Leu Phe Tyr Pro Gly
165 170 175
Ala Ala His Ser Thr Asp Asn Leu Val Val Tyr Val Pro Ser Ala Ser
180 185 190
Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu Leu Ser Arg Thr Ser Ala
195 200 205
Gly Asn Val Ala Asp Ala Asp Leu Ala Glu Trp Pro Thr Ser Ile Glu
210 215 220
Arg Ile Gln Gln His Tyr Pro Glu Ala Gln Phe Val Ile Pro Gly His
225 230 235 240
Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys His Thr Thr Asn Val Val
245 250 255
Lys Ala His Thr Asn Arg Ser Val Val Glu
260 265
<210> 295
<211> 266
<212> PRT
<213> RESISTANCE GENE
<400> 295
Met Phe Lys Leu Leu Ser Lys Leu Leu Val Tyr Leu Thr Ala Ser Ile
1 5 10 15
Met Ala Ile Ala Ser Pro Leu Ala Phe Ser Val Asp Ser Ser Gly Glu
20 25 30
Tyr Pro Thr Val Ser Glu Ile Pro Val Gly Glu Val Arg Leu Tyr Gln
35 40 45
Ile Ala Asp Gly Val Trp Ser His Ile Ala Thr Gln Ser Phe Asp Gly
50 55 60
Ala Val Tyr Pro Ser Asn Gly Leu Ile Val Arg Asp Gly Asp Glu Leu
65 70 75 80
Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys Asn Thr Ala Ala Leu Leu
85 90 95
Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro Val Thr Arg Ala Val Ser
100 105 110
Thr His Phe His Asp Asp Arg Val Gly Gly Val Asp Val Leu Arg Ala
115 120 125
Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser Thr Arg Arg Leu Ala Glu
130 135 140
Val Glu Gly Asn Glu Ile Pro Thr His Ser Leu Glu Gly Leu Ser Ser
145 150 155 160
Ser Gly Asp Ala Val Arg Phe Gly Pro Val Glu Leu Phe Tyr Pro Gly
165 170 175
Ala Ala His Ser Thr Asp Asn Leu Val Val Tyr Val Pro Ser Ala Ser
180 185 190
Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu Leu Ser Arg Thr Ser Ala
195 200 205
Gly Asn Val Ala Asp Ala Asp Leu Ala Glu Trp Pro Thr Ser Ile Glu
210 215 220
Arg Ile Gln Gln His Tyr Pro Glu Ala Gln Tyr Val Ile Pro Gly His
225 230 235 240
Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys His Thr Thr Asn Val Val
245 250 255
Lys Ala His Thr Asn Arg Ser Val Val Glu
260 265
<210> 296
<211> 266
<212> PRT
<213> RESISTANCE GENE
<400> 296
Met Phe Lys Leu Leu Ser Lys Leu Leu Val Tyr Leu Thr Ala Ser Ile
1 5 10 15
Met Ala Ile Ala Ser Pro Leu Ala Phe Ser Val Asp Ser Ser Gly Glu
20 25 30
Tyr Pro Thr Val Ser Glu Ile Pro Val Gly Glu Val Arg Leu Tyr Gln
35 40 45
Ile Ala Asp Gly Val Trp Ser His Ile Ala Thr Gln Ser Phe Asp Gly
50 55 60
Ala Val Tyr Pro Ser Asn Gly Leu Ile Val Arg Asp Gly Asp Glu Leu
65 70 75 80
Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys Asn Thr Ala Ala Leu Leu
85 90 95
Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro Val Thr Arg Ala Val Ser
100 105 110
Thr His Phe His Asp Asp Arg Val Gly Gly Val Asp Val Leu Arg Ala
115 120 125
Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser Thr Arg Arg Leu Ala Glu
130 135 140
Val Glu Gly Ser Glu Ile Pro Thr His Ser Leu Glu Gly Leu Ser Ser
145 150 155 160
Ser Gly Asp Ala Val Arg Phe Gly Pro Val Glu Leu Phe Tyr Pro Gly
165 170 175
Ala Ala His Ser Thr Asp Asn Leu Val Val Tyr Val Pro Ser Ala Ser
180 185 190
Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu Leu Ser Arg Thr Ser Ala
195 200 205
Gly Asn Val Ala Asp Ala Asp Leu Ala Glu Trp Pro Thr Ser Ile Glu
210 215 220
Arg Ile Gln Gln His Tyr Pro Glu Ala Gln Phe Val Ile Pro Gly His
225 230 235 240
Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys His Thr Thr Asn Val Val
245 250 255
Lys Ala His Thr Asn Arg Ser Val Val Glu
260 265
<210> 297
<211> 266
<212> PRT
<213> RESISTANCE GENE
<400> 297
Met Leu Lys Val Ile Ser Ser Leu Leu Val Tyr Met Thr Ala Ser Val
1 5 10 15
Met Ala Val Ala Ser Pro Leu Ala His Ser Gly Glu Pro Ser Ser Glu
20 25 30
Tyr Pro Thr Val Asn Glu Ile Pro Val Gly Glu Val Arg Leu Tyr Gln
35 40 45
Ile Ala Asp Gly Val Trp Ser His Ile Ala Thr Gln Ser Phe Asp Gly
50 55 60
Ala Val Tyr Pro Ser Asn Gly Leu Ile Val Arg Asp Gly Asp Glu Leu
65 70 75 80
Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys Asn Thr Ala Ala Leu Leu
85 90 95
Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro Val Thr Arg Ala Val Ser
100 105 110
Thr His Phe His Asp Asp Arg Val Gly Gly Val Asp Val Leu Arg Ala
115 120 125
Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser Thr Arg Arg Leu Ala Glu
130 135 140
Ala Glu Gly Asn Glu Ile Pro Thr His Ser Leu Glu Gly Leu Ser Ser
145 150 155 160
Ser Gly Asp Ala Val Arg Phe Gly Pro Val Glu Leu Phe Tyr Pro Gly
165 170 175
Ala Ala His Ser Thr Asp Asn Leu Val Val Tyr Val Pro Ser Ala Asn
180 185 190
Val Leu Tyr Gly Gly Cys Ala Val His Glu Leu Ser Arg Thr Ser Ala
195 200 205
Gly Asn Val Ala Asp Ala Asp Leu Ala Glu Trp Pro Thr Ser Val Glu
210 215 220
Arg Ile Gln Lys His Tyr Pro Glu Ala Glu Val Val Ile Pro Gly His
225 230 235 240
Gly Leu Pro Gly Gly Leu Asp Leu Leu Gln His Thr Ala Asn Val Val
245 250 255
Lys Ala His Lys Asn Arg Ser Val Ala Glu
260 265
<210> 298
<211> 266
<212> PRT
<213> RESISTANCE GENE
<400> 298
Met Leu Lys Val Ile Ser Ser Leu Leu Val Tyr Met Thr Ala Ser Val
1 5 10 15
Met Ala Val Ala Ser Pro Leu Ala His Ser Gly Glu Pro Ser Gly Glu
20 25 30
Tyr Pro Thr Val Asn Glu Ile Pro Val Gly Glu Val Arg Leu Tyr Gln
35 40 45
Ile Ala Asp Gly Val Trp Ser His Ile Ala Thr Gln Ser Phe Asp Gly
50 55 60
Ala Val Tyr Pro Ser Asn Gly Leu Ile Val Arg Asp Gly Asp Glu Leu
65 70 75 80
Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys Asn Thr Ala Ala Leu Leu
85 90 95
Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro Val Thr Arg Ala Val Ser
100 105 110
Thr His Phe His Asp Asp Arg Val Gly Gly Val Asp Val Leu Arg Ala
115 120 125
Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser Thr Arg Arg Leu Ala Glu
130 135 140
Ala Glu Gly Asn Glu Ile Pro Thr His Ser Leu Glu Gly Leu Ser Ser
145 150 155 160
Ser Gly Asp Ala Val Arg Phe Gly Pro Val Glu Leu Phe Tyr Pro Gly
165 170 175
Ala Ala His Ser Thr Asp Asn Leu Val Val Tyr Val Pro Ser Ala Asn
180 185 190
Val Leu Tyr Gly Gly Cys Ala Val His Glu Leu Ser Ser Thr Ser Ala
195 200 205
Gly Asn Val Ala Asp Ala Asp Leu Ala Glu Trp Pro Thr Ser Ile Glu
210 215 220
Arg Ile Gln Gln His Tyr Pro Glu Ala Gln Phe Val Ile Pro Gly His
225 230 235 240
Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys His Thr Thr Asn Val Val
245 250 255
Lys Ala His Thr Asn Arg Ser Val Val Glu
260 265
<210> 299
<211> 266
<212> PRT
<213> RESISTANCE GENE
<400> 299
Met Leu Lys Val Ile Ser Ser Leu Leu Phe Tyr Met Thr Ala Ser Leu
1 5 10 15
Met Ala Val Ala Ser Pro Leu Ala His Ser Gly Glu Ser Arg Gly Glu
20 25 30
Tyr Pro Thr Val Ser Glu Ile Pro Val Gly Glu Val Arg Leu Tyr Gln
35 40 45
Ile Asp Asp Gly Val Trp Ser His Ile Ala Thr His Thr Phe Asp Gly
50 55 60
Val Val Tyr Pro Ser Asn Gly Leu Ile Val Arg Asp Gly Asp Glu Leu
65 70 75 80
Leu Leu Ile Asp Thr Ala Trp Gly Thr Lys Asn Thr Val Ala Leu Leu
85 90 95
Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro Val Thr Arg Ser Val Ser
100 105 110
Thr His Phe His Asp Asp Arg Val Gly Gly Val Asp Ala Leu Arg Ala
115 120 125
Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser Thr Arg Arg Leu Ala Glu
130 135 140
Ala Glu Gly Asn Glu Val Pro Thr His Ser Leu Glu Gly Leu Ser Ser
145 150 155 160
Ser Gly Asp Ala Val Arg Phe Gly Pro Val Glu Leu Phe Tyr Pro Gly
165 170 175
Ala Ala His Ser Thr Asp Asn Leu Val Val Tyr Val Pro Ser Ala Asn
180 185 190
Val Leu Tyr Gly Gly Cys Ala Val Leu Glu Leu Ser Arg Thr Ser Ala
195 200 205
Gly Asn Val Ala Asp Ala Asp Leu Ala Glu Trp Pro Gly Ser Val Glu
210 215 220
Arg Ile Gln Gln His Tyr Pro Glu Ala Glu Val Val Ile Pro Gly His
225 230 235 240
Gly Leu Pro Gly Gly Leu Asp Leu Leu Gln His Thr Ala Asn Val Val
245 250 255
Lys Ala His Thr Asn Arg Ser Val Ala Glu
260 265
<210> 300
<211> 266
<212> PRT
<213> RESISTANCE GENE
<400> 300
Met Phe Lys Leu Leu Ser Lys Leu Leu Val Tyr Leu Thr Ala Ser Met
1 5 10 15
Met Ala Ile Ala Ser Pro Leu Ala Phe Ser Val Asp Ser Ser Gly Glu
20 25 30
Tyr Pro Thr Val Ser Glu Ile Pro Val Gly Glu Val Arg Leu Tyr Gln
35 40 45
Ile Ala Asp Gly Val Trp Ser His Ile Ala Thr Gln Ser Phe Asp Gly
50 55 60
Ala Val Tyr Pro Ser Asn Gly Leu Ile Val Arg Asp Gly Asp Glu Leu
65 70 75 80
Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys Asn Thr Ala Ala Leu Leu
85 90 95
Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro Val Thr Arg Ala Val Ser
100 105 110
Thr His Phe His Asp Asp Arg Val Gly Gly Val Asp Val Leu Arg Ala
115 120 125
Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser Thr Arg Arg Leu Ala Glu
130 135 140
Val Glu Gly Asn Glu Ile Pro Thr His Ser Leu Glu Gly Leu Ser Ser
145 150 155 160
Ser Gly Asp Ala Val Arg Phe Gly Pro Val Glu Leu Phe Tyr Pro Gly
165 170 175
Ala Ala His Ser Thr Asp Asn Leu Val Val Tyr Val Pro Ser Ala Ser
180 185 190
Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu Leu Ser Arg Thr Ser Ala
195 200 205
Gly Asn Val Ala Asp Ala Asp Leu Ala Glu Trp Pro Thr Ser Ile Glu
210 215 220
Arg Ile Gln Gln His Tyr Pro Glu Ala Gln Phe Val Ile Pro Gly His
225 230 235 240
Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys His Thr Thr Asn Val Val
245 250 255
Lys Ala His Thr Asn Arg Ser Val Val Glu
260 265
<210> 301
<211> 266
<212> PRT
<213> RESISTANCE GENE
<400> 301
Met Phe Lys Leu Leu Ser Lys Leu Leu Val Tyr Leu Thr Ala Ser Ile
1 5 10 15
Met Ala Ile Ala Ser Pro Leu Ala Phe Ser Val Asp Ser Ser Gly Glu
20 25 30
Tyr Pro Thr Val Ser Glu Ile Pro Val Gly Glu Val Arg Leu Tyr Gln
35 40 45
Ile Ala Asp Gly Val Trp Ser His Ile Ala Thr Gln Ser Phe Asp Gly
50 55 60
Ala Val Tyr Pro Ser Asn Gly Leu Ile Val Arg Asp Gly Asp Glu Leu
65 70 75 80
Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys Asn Thr Ala Ala Leu Leu
85 90 95
Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro Val Thr Arg Ala Val Ser
100 105 110
Thr His Phe His Asp Asp Arg Val Gly Gly Val Asp Val Leu Arg Ala
115 120 125
Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser Thr Arg Arg Leu Ala Glu
130 135 140
Val Glu Gly Asn Glu Ile Pro Thr His Ser Leu Glu Gly Leu Ser Ser
145 150 155 160
Ser Gly Asp Ala Val Arg Phe Gly Pro Val Glu Leu Phe Tyr Pro Gly
165 170 175
Ala Ala His Ser Thr Asp Asn Leu Val Val Tyr Val Pro Ser Ala Ser
180 185 190
Val Leu Phe Gly Gly Cys Ala Ile Tyr Glu Leu Ser Arg Thr Ser Ala
195 200 205
Gly Asn Val Ala Asp Ala Asp Leu Ala Glu Trp Pro Thr Ser Ile Glu
210 215 220
Arg Ile Gln Gln His Tyr Pro Glu Ala Gln Phe Val Ile Pro Gly His
225 230 235 240
Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys His Thr Thr Asn Val Val
245 250 255
Lys Ala His Thr Asn Arg Ser Val Val Glu
260 265
<210> 302
<211> 266
<212> PRT
<213> RESISTANCE GENE
<400> 302
Met Phe Lys Leu Leu Ser Lys Leu Leu Val Tyr Leu Thr Ala Ser Ile
1 5 10 15
Met Ala Ile Ala Ser Pro Leu Ala Phe Ser Val Asp Ser Ser Gly Glu
20 25 30
Tyr Pro Thr Val Ser Glu Ile Pro Val Gly Glu Val Arg Leu Tyr Gln
35 40 45
Ile Ala Asp Gly Val Trp Leu His Ile Ala Thr Gln Ser Phe Asp Gly
50 55 60
Ala Val Tyr Pro Ser Asn Gly Leu Ile Val Arg Asp Gly Asp Glu Leu
65 70 75 80
Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys Asn Thr Ala Ala Leu Leu
85 90 95
Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro Val Thr Arg Ala Val Ser
100 105 110
Thr His Phe His Asp Asp Arg Val Gly Gly Val Asp Val Leu Arg Ala
115 120 125
Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser Thr Arg Arg Leu Ala Glu
130 135 140
Val Glu Gly Asn Glu Ile Pro Thr His Ser Leu Glu Gly Leu Ser Ser
145 150 155 160
Ser Gly Asp Ala Val Arg Phe Gly Pro Val Glu Leu Phe Tyr Pro Gly
165 170 175
Ala Ala His Ser Thr Asp Asn Leu Val Val Tyr Val Pro Ser Ala Ser
180 185 190
Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu Leu Ser Arg Thr Ser Ala
195 200 205
Gly Asn Val Ala Asp Ala Asp Leu Ala Glu Trp Pro Thr Ser Ile Glu
210 215 220
Arg Ile Gln Gln His Tyr Pro Glu Ala Gln Phe Val Ile Pro Gly His
225 230 235 240
Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys His Thr Thr Asn Val Val
245 250 255
Lys Ala His Thr Asn Arg Ser Val Val Glu
260 265
<210> 303
<211> 266
<212> PRT
<213> RESISTANCE GENE
<400> 303
Met Phe Lys Leu Leu Ser Lys Leu Leu Val Tyr Leu Thr Ala Ser Ile
1 5 10 15
Met Ala Ile Ala Ser Pro Leu Ala Phe Ser Val Asp Ser Ser Gly Glu
20 25 30
Tyr Pro Thr Val Ser Glu Ile Pro Val Gly Glu Val Arg Leu Tyr Gln
35 40 45
Ile Ala Asp Gly Val Trp Ser His Ile Ala Thr Gln Ser Phe Asp Gly
50 55 60
Ala Val Tyr Pro Ser Asn Gly Leu Ile Val Arg Asp Gly Asp Glu Leu
65 70 75 80
Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys Asn Thr Ala Ala Leu Leu
85 90 95
Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro Val Thr Arg Ala Val Ser
100 105 110
Thr His Phe His Asp Asp Arg Val Gly Gly Val Asp Val Leu Arg Ala
115 120 125
Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser Thr Arg Arg Leu Ala Glu
130 135 140
Val Glu Gly Asn Glu Ile Pro Thr His Ser Leu Glu Gly Leu Ser Ser
145 150 155 160
Ser Gly Asp Ala Val Arg Phe Gly Pro Val Glu Leu Phe Tyr Pro Gly
165 170 175
Ala Ala His Ser Thr Asp Asn Leu Val Val Tyr Val Pro Ser Ala Ser
180 185 190
Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu Leu Ser Ser Thr Ser Ala
195 200 205
Gly Asn Val Ala Asp Ala Asp Leu Ala Glu Trp Pro Thr Ser Ile Glu
210 215 220
Arg Ile Gln Gln His Tyr Pro Glu Ala Gln Phe Val Ile Pro Gly His
225 230 235 240
Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys His Thr Thr Asn Val Val
245 250 255
Lys Ala His Thr Asn Arg Ser Val Val Glu
260 265
<210> 304
<211> 266
<212> PRT
<213> RESISTANCE GENE
<400> 304
Met Leu Lys Val Ile Ser Ser Leu Leu Val Tyr Met Thr Ala Ser Val
1 5 10 15
Met Ala Val Ala Ser Pro Leu Ala His Ser Gly Glu Pro Ser Gly Glu
20 25 30
Tyr Pro Thr Val Asn Glu Ile Pro Val Gly Glu Val Arg Leu Tyr Gln
35 40 45
Ile Ala Asp Gly Val Trp Ser His Ile Ala Thr Gln Ser Phe Asp Gly
50 55 60
Ala Val Tyr Pro Ser Asn Gly Leu Ile Val Arg Asp Gly Asp Glu Leu
65 70 75 80
Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys Asn Thr Ala Ala Leu Leu
85 90 95
Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro Val Thr Arg Ala Val Ser
100 105 110
Thr His Phe His Asp Asp Arg Val Gly Gly Val Asp Val Leu Arg Ala
115 120 125
Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser Thr Arg Arg Leu Ala Glu
130 135 140
Ala Glu Gly Asn Glu Ile Pro Thr His Ser Leu Glu Gly Leu Ser Ser
145 150 155 160
Ser Gly Asp Ala Val Arg Phe Gly Pro Val Glu Leu Phe Tyr Pro Gly
165 170 175
Ala Ala His Ser Thr Asp Asn Leu Val Val Tyr Val Pro Ser Ala Lys
180 185 190
Val Leu Tyr Gly Gly Cys Ala Val His Glu Leu Ser Arg Thr Ser Ala
195 200 205
Gly Asn Val Ala Asp Ala Asp Leu Ala Glu Trp Pro Thr Ser Val Glu
210 215 220
Arg Ile Gln Lys His Tyr Pro Glu Ala Glu Val Val Ile Pro Gly His
225 230 235 240
Gly Leu Pro Gly Gly Leu Asp Leu Leu Gln His Thr Ala Asn Val Val
245 250 255
Lys Ala His Lys Asn Arg Ser Val Ala Glu
260 265
<210> 305
<211> 266
<212> PRT
<213> RESISTANCE GENE
<400> 305
Met Phe Lys Leu Leu Ser Lys Leu Leu Val Tyr Leu Thr Ala Ser Ile
1 5 10 15
Met Ala Ile Ala Ser Pro Leu Ala Phe Ser Val Asp Ser Ser Gly Glu
20 25 30
Tyr Pro Thr Val Ser Glu Ile Pro Val Gly Glu Val Arg Leu Tyr Gln
35 40 45
Ile Ala Asp Gly Val Trp Ser His Ile Ala Thr Gln Ser Phe Asp Gly
50 55 60
Ala Val Tyr Pro Ser Asn Gly Leu Ile Val Arg Asp Gly Asp Glu Leu
65 70 75 80
Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys Asn Thr Ala Ala Leu Leu
85 90 95
Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro Val Thr Arg Ala Val Ser
100 105 110
Thr His Phe His Asp Asp Arg Val Gly Gly Val Asp Val Leu Arg Ala
115 120 125
Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser Thr Arg Arg Leu Ala Glu
130 135 140
Val Glu Gly Asn Glu Ile Pro Thr His Ser Leu Glu Gly Leu Ser Ser
145 150 155 160
Ser Gly Asp Ala Val Arg Phe Gly Pro Val Glu Leu Phe Tyr Pro Gly
165 170 175
Ala Ala His Ser Thr Asp Asn Leu Val Val Tyr Val Pro Ser Ala Ser
180 185 190
Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu Leu Ser Leu Thr Ser Ala
195 200 205
Gly Asn Val Ala Asp Ala Asp Leu Ala Glu Trp Pro Thr Ser Ile Glu
210 215 220
Arg Ile Gln Gln His Tyr Pro Glu Ala Gln Phe Val Ile Pro Gly His
225 230 235 240
Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys His Thr Thr Asn Val Val
245 250 255
Lys Ala His Thr Asn Arg Ser Val Val Glu
260 265
<210> 306
<211> 266
<212> PRT
<213> RESISTANCE GENE
<400> 306
Met Leu Lys Val Ile Ser Ser Leu Leu Val Tyr Met Thr Ala Ser Val
1 5 10 15
Met Ala Val Ala Ser Pro Leu Ala His Ser Gly Glu Pro Ser Gly Glu
20 25 30
Tyr Pro Thr Val Asn Glu Ile Pro Val Gly Glu Val Arg Leu Tyr Gln
35 40 45
Ile Ala Asp Gly Val Trp Ser His Ile Ala Thr Gln Ser Phe Asp Gly
50 55 60
Ala Val Tyr Pro Ser Asn Gly Leu Ile Val Arg Asp Gly Asp Glu Leu
65 70 75 80
Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys Asn Thr Ala Ala Leu Leu
85 90 95
Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro Val Thr Arg Ala Val Ser
100 105 110
Thr His Phe His Asp Asp Arg Val Gly Gly Val Asp Val Leu Arg Lys
115 120 125
Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser Thr Arg Arg Leu Ala Glu
130 135 140
Ala Glu Gly Asn Glu Ile Pro Thr His Ser Leu Glu Gly Leu Ser Ser
145 150 155 160
Ser Gly Asp Ala Val Arg Phe Gly Pro Val Glu Leu Phe Tyr Pro Gly
165 170 175
Ala Ala His Ser Thr Asp Asn Leu Val Val Tyr Val Pro Ser Ala Asn
180 185 190
Val Leu Tyr Gly Gly Cys Ala Val Leu Ala Leu Ser Arg Thr Ser Ala
195 200 205
Gly Asn Val Ala Asp Ala Asp Leu Ala Glu Trp Pro Thr Ser Val Glu
210 215 220
Arg Ile Gln Lys His Tyr Pro Glu Ala Gln Phe Val Ile Pro Gly His
225 230 235 240
Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys His Thr Thr Asn Val Val
245 250 255
Lys Ala His Thr Asn Arg Ser Val Val Glu
260 265
<210> 307
<211> 266
<212> PRT
<213> RESISTANCE GENE
<400> 307
Met Leu Lys Val Ile Ser Ser Leu Leu Val Tyr Met Thr Ala Ser Val
1 5 10 15
Met Ala Val Ala Ser Pro Leu Ala His Ser Gly Glu Pro Ser Gly Glu
20 25 30
Tyr Pro Thr Val Asn Glu Ile Pro Val Gly Glu Val Arg Leu Tyr Gln
35 40 45
Ile Ala Asp Gly Val Trp Ser His Ile Ser Thr Gln Ser Phe Asp Gly
50 55 60
Ala Val Tyr Pro Ser Asn Gly Leu Ile Val Arg Asp Gly Asp Glu Leu
65 70 75 80
Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys Asn Thr Ala Ala Leu Leu
85 90 95
Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro Val Thr Arg Ala Val Ser
100 105 110
Thr His Phe His Asp Asp Arg Val Gly Gly Val Asp Val Leu Arg Ala
115 120 125
Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser Thr Arg Arg Leu Ala Glu
130 135 140
Ala Glu Gly Asn Glu Ile Pro Thr His Ser Leu Glu Gly Leu Ser Ser
145 150 155 160
Ser Gly Asp Ala Val Arg Phe Gly Pro Val Glu Leu Phe Tyr Pro Gly
165 170 175
Ala Ala His Ser Thr Asp Asn Leu Val Val Tyr Val Pro Ser Ala Asn
180 185 190
Val Leu Tyr Gly Gly Cys Ala Val His Glu Leu Ser Ser Thr Ser Ala
195 200 205
Gly Asn Val Ala Asp Ala Asp Leu Ala Glu Trp Pro Thr Ser Val Glu
210 215 220
Arg Ile Gln Lys His Tyr Pro Glu Ala Glu Val Val Ile Pro Gly His
225 230 235 240
Gly Leu Pro Gly Gly Leu Asp Leu Leu Gln His Thr Ala Asn Val Val
245 250 255
Lys Ala His Lys Asn Arg Ser Val Ala Glu
260 265
<210> 308
<211> 266
<212> PRT
<213> RESISTANCE GENE
<400> 308
Met Leu Lys Val Ile Ser Ser Leu Leu Val Tyr Met Thr Ala Ser Val
1 5 10 15
Met Ala Val Ala Ser Pro Leu Ala His Ser Gly Glu Pro Ser Gly Glu
20 25 30
Tyr Pro Thr Val Asn Glu Ile Pro Val Gly Glu Val Arg Leu Tyr Gln
35 40 45
Ile Ala Asp Gly Val Trp Ser His Ile Ala Thr Gln Ser Phe Asp Gly
50 55 60
Ala Val Tyr Pro Ser Asn Gly Leu Ile Val Arg Asp Gly Asp Glu Leu
65 70 75 80
Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys Asn Thr Ala Ala Leu Leu
85 90 95
Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro Val Thr Arg Ala Val Ser
100 105 110
Thr His Phe His Asp Asp Arg Val Gly Gly Val Asp Val Leu Arg Ala
115 120 125
Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser Thr Arg Arg Leu Ala Glu
130 135 140
Ala Glu Gly Asn Glu Ile Pro Thr His Ser Leu Glu Gly Leu Ser Ser
145 150 155 160
Ser Gly Asp Ala Val Arg Phe Gly Pro Val Glu Leu Phe Tyr Pro Gly
165 170 175
Ala Ala His Ser Thr Asp Asn Leu Val Val Tyr Val Pro Ser Ala Asn
180 185 190
Val Leu Tyr Gly Gly Cys Ala Val Leu Glu Leu Ser Arg Thr Ser Ala
195 200 205
Gly Asn Val Ala Asp Ala Asp Leu Ala Glu Trp Pro Thr Ser Val Glu
210 215 220
Arg Ile Gln Lys His Tyr Pro Glu Ala Glu Val Val Ile Pro Gly His
225 230 235 240
Gly Leu Pro Gly Gly Leu Asp Leu Leu Gln His Thr Ala Asn Val Val
245 250 255
Lys Ala His Lys Asn Arg Ser Val Ala Glu
260 265
<210> 309
<211> 266
<212> PRT
<213> RESISTANCE GENE
<400> 309
Met Phe Lys Leu Leu Ser Lys Leu Leu Val Tyr Leu Thr Ala Ser Ile
1 5 10 15
Met Ala Ile Ala Ser Pro Leu Ala Phe Ser Val Asp Ser Ser Gly Glu
20 25 30
Tyr Pro Thr Val Asn Glu Ile Pro Val Gly Glu Val Arg Leu Tyr Gln
35 40 45
Ile Ala Asp Gly Val Trp Ser His Ile Ala Thr Gln Ser Phe Asp Gly
50 55 60
Ala Val Tyr Pro Ser Asn Gly Leu Ile Val Arg Asp Gly Asp Glu Leu
65 70 75 80
Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys Asn Thr Ala Ala Leu Leu
85 90 95
Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro Val Thr Arg Ala Val Ser
100 105 110
Thr His Phe His Asp Asp Arg Val Gly Gly Val Asp Val Leu Arg Ala
115 120 125
Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser Thr Arg Arg Leu Ala Glu
130 135 140
Val Glu Gly Asn Glu Ile Pro Thr His Ser Leu Glu Gly Leu Ser Ser
145 150 155 160
Ser Gly Asp Ala Val Arg Phe Gly Pro Val Glu Leu Phe Tyr Pro Gly
165 170 175
Ala Ala His Ser Thr Asp Asn Leu Val Val Tyr Val Pro Ser Ala Ser
180 185 190
Val Leu Tyr Gly Gly Cys Ala Ile Tyr Glu Leu Ser Arg Thr Ser Ala
195 200 205
Gly Asn Val Ala Asp Ala Asp Leu Ala Glu Trp Pro Thr Ser Ile Glu
210 215 220
Arg Ile Gln Gln His Tyr Pro Glu Ala Gln Phe Val Ile Pro Gly His
225 230 235 240
Gly Leu Pro Gly Gly Leu Asp Leu Leu Lys His Thr Thr Asn Val Val
245 250 255
Lys Ala His Thr Asn Arg Ser Val Val Glu
260 265
<210> 310
<211> 266
<212> PRT
<213> RESISTANCE GENE
<400> 310
Met Leu Lys Val Ile Ser Ser Leu Leu Val Tyr Met Thr Ala Ser Val
1 5 10 15
Met Ala Val Ala Ser Pro Leu Ala His Ser Gly Glu Pro Ser Gly Glu
20 25 30
Tyr Pro Thr Val Asn Glu Ile Pro Val Gly Glu Val Arg Leu Tyr Gln
35 40 45
Ile Ala Asp Gly Val Trp Ser His Ile Ala Thr Gln Ser Phe Asp Gly
50 55 60
Ala Val Tyr Pro Ser Asn Gly Leu Ile Val Arg Asp Gly Asp Glu Leu
65 70 75 80
Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys Asn Thr Ala Ala Leu Leu
85 90 95
Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro Val Thr Arg Ala Val Ser
100 105 110
Thr His Phe His Asp Asp Arg Val Gly Gly Val Asp Val Leu Arg Ala
115 120 125
Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser Thr Arg Arg Leu Ala Glu
130 135 140
Ala Glu Gly Asn Glu Ile Pro Thr His Ser Leu Glu Gly Leu Ser Ser
145 150 155 160
Ser Gly Asp Ala Val Arg Phe Gly Pro Val Glu Leu Phe Tyr Pro Gly
165 170 175
Ala Ala His Ser Thr Asp Asn Leu Val Val Tyr Val Pro Ser Ala Asn
180 185 190
Val Leu Tyr Gly Gly Cys Ala Val His Glu Leu Ser Ser Thr Ser Ala
195 200 205
Gly Asn Val Ala Asp Ala Asp Leu Ala Glu Trp Pro Thr Ser Val Glu
210 215 220
Arg Ile Gln Lys His Tyr Pro Glu Ala Glu Val Val Ile Pro Gly His
225 230 235 240
Gly Leu Pro Gly Gly Leu Asp Leu Leu Gln His Thr Ala Asn Val Val
245 250 255
Lys Ala His Lys Asn Arg Ser Val Ala Glu
260 265
<210> 311
<211> 265
<212> PRT
<213> RESISTANCE GENE
<400> 311
Met Phe Gln Ile Arg Ser Phe Leu Val Gly Ile Ser Ala Phe Val Met
1 5 10 15
Ala Val Leu Gly Ser Ala Ala Tyr Ser Ala Gln Pro Gly Gly Glu Tyr
20 25 30
Pro Thr Val Asp Asp Ile Pro Val Gly Glu Val Arg Leu Tyr Lys Ile
35 40 45
Gly Asp Gly Val Trp Ser His Ile Ala Thr Gln Lys Leu Gly Asp Thr
50 55 60
Val Tyr Ser Ser Asn Gly Leu Ile Val Arg Asp Ala Asp Glu Leu Leu
65 70 75 80
Leu Ile Asp Thr Ala Trp Gly Ala Lys Asn Thr Val Ala Leu Leu Ala
85 90 95
Glu Ile Glu Lys Gln Ile Gly Leu Pro Val Thr Arg Ser Ile Ser Thr
100 105 110
His Phe His Asp Asp Arg Val Gly Gly Val Asp Val Leu Arg Ala Ala
115 120 125
Gly Val Ala Thr Tyr Thr Ser Pro Leu Thr Arg Gln Leu Ala Glu Ala
130 135 140
Ala Gly Asn Glu Val Pro Ala His Ser Leu Lys Ala Leu Ser Ser Ser
145 150 155 160
Gly Asp Val Val Arg Phe Gly Pro Val Glu Val Phe Tyr Pro Gly Ala
165 170 175
Ala His Ser Gly Asp Asn Leu Val Val Tyr Val Pro Ala Val Arg Val
180 185 190
Leu Phe Gly Gly Cys Ala Val His Glu Ala Ser Arg Glu Ser Ala Gly
195 200 205
Asn Val Ala Asp Ala Asn Leu Ala Glu Trp Pro Ala Thr Ile Lys Arg
210 215 220
Ile Gln Gln Arg Tyr Pro Glu Ala Glu Val Val Ile Pro Gly His Gly
225 230 235 240
Leu Pro Gly Gly Leu Glu Leu Leu Gln His Thr Thr Asn Val Val Lys
245 250 255
Thr His Lys Val Arg Pro Val Ala Glu
260 265
<210> 312
<211> 262
<212> PRT
<213> RESISTANCE GENE
<400> 312
Met Phe Lys Leu Leu Ser Lys Leu Leu Val Tyr Leu Thr Ala Ser Ile
1 5 10 15
Met Ala Ile Ala Ser Pro Leu Ala Phe Ser Val Asp Ser Ser Gly Glu
20 25 30
Tyr Pro Thr Val Ser Glu Ile Pro Val Gly Glu Val Arg Leu Tyr Gln
35 40 45
Ile Ala Asp Gly Val Trp Ser His Ile Ala Thr Arg Ser Phe Asp Gly
50 55 60
Ala Val Tyr Pro Ser Asn Gly Leu Ile Val Arg Asp Gly Asp Glu Leu
65 70 75 80
Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys Asn Thr Ala Ala Leu Leu
85 90 95
Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro Val Thr Arg Ala Val Ser
100 105 110
Thr His Phe His Asp Asp Arg Val Gly Gly Val Asp Val Leu Arg Ala
115 120 125
Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser Thr Arg Arg Leu Ala Asn
130 135 140
Glu Ile Pro Thr His Ser Leu Glu Gly Leu Ser Ser Ser Gly Asp Ala
145 150 155 160
Val Arg Phe Gly Pro Val Glu Leu Phe Tyr Pro Gly Ala Ala His Ser
165 170 175
Thr Asp Asn Leu Val Val Tyr Val Pro Ser Ala Ser Val Leu Tyr Gly
180 185 190
Gly Cys Ala Ile Tyr Glu Leu Ser Arg Thr Ser Ala Gly Asn Val Ala
195 200 205
Asp Ala Asp Leu Ala Glu Trp Pro Thr Ser Ile Glu Arg Ile Gln Gln
210 215 220
His Tyr Pro Glu Ala Gln Phe Val Ile Pro Gly His Gly Leu Pro Gly
225 230 235 240
Gly Leu Asp Leu Leu Lys His Thr Thr Asn Val Val Lys Ala His Thr
245 250 255
Asn Arg Ser Val Val Glu
260
<210> 313
<211> 266
<212> PRT
<213> RESISTANCE GENE
<400> 313
Met Leu Lys Val Ile Ser Ser Leu Leu Val Tyr Met Thr Ala Ser Val
1 5 10 15
Met Ala Val Ala Ser Pro Leu Ala His Ser Gly Glu Pro Ser Gly Glu
20 25 30
Tyr Pro Thr Val Asn Glu Ile Pro Val Gly Glu Val Arg Leu Tyr Gln
35 40 45
Ile Ala Asp Gly Val Trp Ser His Ile Ala Thr Gln Ser Phe Asp Gly
50 55 60
Ala Val Tyr Pro Ser Asn Gly Leu Ile Val Arg Asp Gly Asp Glu Leu
65 70 75 80
Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys Asn Thr Ala Ala Leu Leu
85 90 95
Ala Glu Ile Glu Lys Gln Ile Gly Leu Pro Val Thr Arg Ala Val Ser
100 105 110
Thr His Phe His Asp Asp Arg Val Gly Gly Val Asp Val Leu Arg Ala
115 120 125
Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser Thr Arg Arg Leu Ala Glu
130 135 140
Ala Glu Gly Asn Glu Ile Pro Thr His Ser Leu Glu Gly Leu Ser Ser
145 150 155 160
Ser Gly Asp Ala Val Arg Phe Gly Pro Val Glu Leu Phe Tyr Pro Gly
165 170 175
Ala Ala His Ser Thr Asp Asn Leu Val Val Tyr Val Pro Ser Ala Asn
180 185 190
Val Leu Tyr Gly Gly Cys Ala Val Leu Glu Leu Ser Ser Thr Ser Ala
195 200 205
Gly Asn Val Ala Asp Ala Asp Leu Ala Glu Trp Pro Thr Ser Val Glu
210 215 220
Arg Ile Gln Lys His Tyr Pro Glu Ala Glu Val Val Ile Pro Gly His
225 230 235 240
Gly Leu Pro Gly Gly Leu Asp Leu Leu Gln His Thr Ala Asn Val Val
245 250 255
Lys Ala His Lys Asn Arg Ser Val Ala Glu
260 265
<210> 314
<211> 13
<212> PRT
<213> RESISTANCE GENE
<400> 314
Ala Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser Ala Arg
1 5 10
<210> 315
<211> 13
<212> PRT
<213> RESISTANCE GENE
<400> 315
Ala Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser Ile Arg
1 5 10
<210> 316
<211> 13
<212> PRT
<213> RESISTANCE GENE
<400> 316
Ala Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser Thr Arg
1 5 10
<210> 317
<211> 13
<212> PRT
<213> RESISTANCE GENE
<400> 317
Ala Ala Gly Val Ala Thr Tyr Thr Ser Pro Leu Thr Arg
1 5 10
<210> 318
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 318
Ala Gly Val Ala Thr Tyr Ala Ser Pro Ser Thr Arg
1 5 10
<210> 319
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 319
Ala His Thr Asn Arg
1 5
<210> 320
<211> 10
<212> PRT
<213> RESISTANCE GENE
<400> 320
Ala Leu Ser Ser Ser Gly Asp Val Val Arg
1 5 10
<210> 321
<211> 10
<212> PRT
<213> RESISTANCE GENE
<400> 321
Ala Val Ser Thr His Phe His Asp Asp Arg
1 5 10
<210> 322
<211> 15
<212> PRT
<213> RESISTANCE GENE
<400> 322
Asp Ala Asp Glu Leu Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys
1 5 10 15
<210> 323
<211> 15
<212> PRT
<213> RESISTANCE GENE
<400> 323
Asp Gly Asp Glu Leu Leu Leu Ile Asp Thr Ala Trp Gly Ala Lys
1 5 10 15
<210> 324
<211> 15
<212> PRT
<213> RESISTANCE GENE
<400> 324
Asp Gly Asp Glu Leu Leu Leu Ile Asp Thr Ala Trp Gly Thr Lys
1 5 10 15
<210> 325
<211> 19
<212> PRT
<213> RESISTANCE GENE
<400> 325
Glu Ser Ala Gly Asn Val Ala Asp Ala Asn Leu Ala Glu Trp Pro Ala
1 5 10 15
Thr Ile Lys
<210> 326
<211> 15
<212> PRT
<213> RESISTANCE GENE
<400> 326
Gly Glu Tyr Pro Thr Val Ser Glu Ile Pro Val Gly Glu Val Arg
1 5 10 15
<210> 327
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 327
His Thr Thr Asn Val Val Lys
1 5
<210> 328
<211> 13
<212> PRT
<213> RESISTANCE GENE
<400> 328
Ile Gly Asp Gly Val Trp Ser His Ile Ala Thr Gln Lys
1 5 10
<210> 329
<211> 21
<212> PRT
<213> RESISTANCE GENE
<400> 329
Leu Ala Asn Glu Ile Pro Thr His Ser Leu Glu Gly Leu Ser Ser Ser
1 5 10 15
Gly Asp Ala Val Arg
20
<210> 330
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 330
Leu Gly Asp Thr Val Tyr Ser Ser Asn Gly Leu Ile Val Arg
1 5 10
<210> 331
<211> 15
<212> PRT
<213> RESISTANCE GENE
<400> 331
Leu Tyr Gln Ile Ala Asp Gly Val Trp Ser His Ile Ala Thr Lys
1 5 10 15
<210> 332
<211> 15
<212> PRT
<213> RESISTANCE GENE
<400> 332
Leu Tyr Gln Ile Ala Asp Gly Val Trp Ser His Ile Ala Thr Arg
1 5 10 15
<210> 333
<211> 11
<212> PRT
<213> RESISTANCE GENE
<400> 333
Asn Thr Ala Ala Leu Leu Ala Glu Ile Glu Lys
1 5 10
<210> 334
<211> 11
<212> PRT
<213> RESISTANCE GENE
<400> 334
Asn Thr Val Ala Leu Leu Ala Glu Ile Glu Lys
1 5 10
<210> 335
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 335
Gln Ile Gly Leu Pro Val Thr Arg
1 5
<210> 336
<211> 16
<212> PRT
<213> RESISTANCE GENE
<400> 336
Gln Leu Ala Glu Ala Ala Gly Asn Glu Val Pro Ala His Ser Leu Lys
1 5 10 15
<210> 337
<211> 15
<212> PRT
<213> RESISTANCE GENE
<400> 337
Ser Phe Asp Gly Ala Val Tyr Pro Ser Asn Gly Leu Ile Val Arg
1 5 10 15
<210> 338
<211> 10
<212> PRT
<213> RESISTANCE GENE
<400> 338
Ser Ile Ser Thr His Phe His Asp Asp Arg
1 5 10
<210> 339
<211> 10
<212> PRT
<213> RESISTANCE GENE
<400> 339
Ser Val Ser Thr His Phe His Asp Asp Arg
1 5 10
<210> 340
<211> 20
<212> PRT
<213> RESISTANCE GENE
<400> 340
Thr Ser Ala Gly Asn Val Ala Asp Ala Asp Leu Ala Glu Trp Pro Gly
1 5 10 15
Ser Val Glu Arg
20
<210> 341
<211> 20
<212> PRT
<213> RESISTANCE GENE
<400> 341
Thr Ser Ala Gly Asn Val Ala Asp Ala Asp Leu Ala Glu Trp Pro Thr
1 5 10 15
Ser Ile Glu Arg
20
<210> 342
<211> 20
<212> PRT
<213> RESISTANCE GENE
<400> 342
Thr Ser Ala Gly Asn Val Ala Asp Ala Asp Leu Ala Glu Trp Pro Thr
1 5 10 15
Ser Val Glu Arg
20
<210> 343
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 343
Val Gly Gly Val Asp Ala Leu Arg
1 5
<210> 344
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 344
Val Gly Gly Val Asp Val Leu Arg
1 5
<210> 345
<211> 13
<212> PRT
<213> RESISTANCE GENE
<400> 345
Val Leu Phe Gly Gly Cys Ala Val His Glu Ala Ser Arg
1 5 10
<210> 346
<211> 13
<212> PRT
<213> RESISTANCE GENE
<400> 346
Val Leu Tyr Gly Gly Cys Ala Val His Glu Leu Ser Arg
1 5 10
<210> 347
<211> 264
<212> PRT
<213> RESISTANCE GENE
<400> 347
Met Ser Arg Leu Leu Leu Ser Gly Leu Leu Ala Thr Gly Leu Leu Cys
1 5 10 15
Ala Val Pro Ala Ser Ala Ala Ser Gly Cys Phe Leu Tyr Ala Asp Gly
20 25 30
Asn Gly Gln Thr Leu Ser Ser Glu Gly Asp Cys Ser Ser Gln Leu Pro
35 40 45
Pro Ala Ser Thr Phe Lys Ile Pro Leu Ala Leu Met Gly Tyr Asp Ser
50 55 60
Gly Phe Leu Val Asn Glu Glu His Pro Ala Leu Pro Tyr Lys Pro Ser
65 70 75 80
Tyr Asp Gly Trp Leu Pro Ala Trp Arg Glu Thr Thr Thr Pro Arg Arg
85 90 95
Trp Glu Thr Tyr Ser Val Val Trp Phe Ser Gln Gln Ile Thr Glu Trp
100 105 110
Leu Gly Met Glu Arg Phe Gln Gln Tyr Val Asp Arg Phe Asp Tyr Gly
115 120 125
Asn Arg Asp Leu Ser Gly Asn Pro Gly Lys His Asp Gly Leu Thr Gln
130 135 140
Ala Trp Leu Ser Ser Ser Leu Ala Ile Ser Pro Glu Glu Gln Ala Arg
145 150 155 160
Phe Leu Gly Lys Met Val Ser Gly Lys Leu Pro Val Ser Ala Gln Thr
165 170 175
Leu Gln Tyr Thr Ala Asn Ile Leu Lys Val Ser Glu Val Glu Gly Trp
180 185 190
Gln Ile His Gly Lys Thr Gly Met Gly Tyr Pro Lys Lys Leu Asp Gly
195 200 205
Ser Leu Asn Arg Asp Gln Gln Ile Gly Trp Phe Val Gly Trp Ala Ser
210 215 220
Lys Pro Gly Lys Gln Leu Ile Phe Val His Thr Val Val Gln Lys Pro
225 230 235 240
Gly Lys Gln Phe Ala Ser Ile Lys Ala Lys Glu Glu Val Leu Ala Ala
245 250 255
Leu Pro Ala Gln Leu Lys Lys Leu
260
<210> 348
<211> 257
<212> PRT
<213> RESISTANCE GENE
<400> 348
Ile Ala Cys Leu Ser Ser Thr Ala Leu Ala Gly Ser Ile Thr Glu Asn
1 5 10 15
Thr Ser Trp Asn Lys Glu Phe Ser Ala Glu Ala Val Asn Gly Val Phe
20 25 30
Val Leu Cys Lys Ser Ser Ser Lys Ser Cys Ala Thr Asn Asp Leu Ala
35 40 45
Arg Ala Ser Lys Glu Tyr Leu Pro Ala Ser Thr Phe Lys Ile Pro Asn
50 55 60
Ala Ile Ile Gly Leu Glu Thr Gly Val Ile Lys Asn Glu His Gln Val
65 70 75 80
Phe Lys Trp Asp Gly Lys Pro Arg Ala Met Lys Gln Trp Glu Arg Asp
85 90 95
Leu Thr Leu Arg Gly Ala Ile Gln Val Ser Ala Val Pro Val Phe Gln
100 105 110
Gln Ile Ala Arg Glu Val Gly Glu Val Arg Met Gln Lys Tyr Leu Lys
115 120 125
Lys Phe Ser Tyr Gly Asn Gln Asn Ile Ser Gly Gly Ile Asp Lys Phe
130 135 140
Trp Leu Glu Asp Gln Leu Arg Ile Ser Ala Val Asn Gln Val Glu Phe
145 150 155 160
Leu Glu Ser Leu Tyr Leu Asn Lys Leu Ser Ala Ser Lys Glu Asn Gln
165 170 175
Leu Ile Val Lys Glu Ala Leu Val Thr Glu Ala Ala Pro Glu Tyr Leu
180 185 190
Val His Ser Lys Thr Gly Phe Ser Gly Val Gly Thr Glu Ser Asn Pro
195 200 205
Gly Val Ala Trp Trp Val Gly Trp Val Glu Lys Glu Thr Glu Val Tyr
210 215 220
Phe Phe Ala Phe Asn Met Asp Ile Asp Asn Glu Ser Lys Leu Pro Leu
225 230 235 240
Arg Lys Ser Ile Pro Thr Lys Ile Met Glu Ser Glu Gly Ile Ile Gly
245 250 255
Gly
<210> 349
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 349
Met Lys Lys Ile Leu Leu Leu His Met Leu Val Phe Val Ser Ala Thr
1 5 10 15
Leu Pro Ile Ser Ser Val Ala Ser Asp Glu Val Glu Thr Leu Lys Cys
20 25 30
Thr Ile Ile Ala Asp Ala Ile Thr Gly Asn Thr Leu Tyr Glu Thr Gly
35 40 45
Glu Cys Ala Arg Arg Val Ser Pro Cys Ser Ser Phe Lys Leu Pro Leu
50 55 60
Ala Ile Met Gly Phe Asp Ser Gly Ile Leu Gln Ser Pro Lys Ser Pro
65 70 75 80
Thr Trp Glu Leu Lys Pro Glu Tyr Asn Pro Ser Pro Arg Asp Arg Thr
85 90 95
Tyr Lys Gln Val Tyr Pro Ala Leu Trp Gln Ser Asp Ser Val Val Trp
100 105 110
Phe Ser Gln Gln Leu Thr Ser Arg Leu Gly Val Asp Arg Phe Thr Glu
115 120 125
Tyr Val Lys Lys Phe Glu Tyr Gly Asn Gln Asp Val Ser Gly Asp Ser
130 135 140
Gly Lys His Asn Gly Leu Thr Gln Ser Trp Leu Met Ser Ser Leu Thr
145 150 155 160
Ile Ser Pro Lys Glu Gln Ile Gln Phe Leu Leu Arg Phe Val Ala His
165 170 175
Lys Leu Pro Val Ser Glu Ala Ala Tyr Asp Met Ala Tyr Ala Thr Ile
180 185 190
Pro Gln Tyr Gln Ala Ala Glu Gly Trp Ala Val His Gly Lys Ser Gly
195 200 205
Ser Gly Trp Leu Arg Asp Asn Asn Gly Lys Ile Asn Glu Ser Arg Pro
210 215 220
Gln Gly Trp Phe Val Gly Trp Ala Glu Lys Asn Gly Arg Gln Val Val
225 230 235 240
Phe Ala Arg Leu Glu Ile Gly Lys Glu Lys Ser Asp Ile Pro Gly Gly
245 250 255
Ser Lys Ala Arg Glu Asp Ile Leu Val Glu Leu Pro Val Leu Met Gly
260 265 270
Asn Lys
<210> 350
<211> 275
<212> PRT
<213> RESISTANCE GENE
<400> 350
Met Ala Ile Arg Ile Phe Ala Ile Leu Phe Ser Ile Phe Ser Leu Ala
1 5 10 15
Thr Phe Ala His Ala Gln Glu Gly Thr Leu Glu Arg Ser Asp Trp Arg
20 25 30
Lys Phe Phe Ser Glu Phe Gln Ala Lys Gly Thr Ile Val Val Ala Asp
35 40 45
Glu Arg Gln Ala Asp Arg Ala Met Leu Val Phe Asp Pro Val Arg Ser
50 55 60
Lys Lys Arg Tyr Ser Pro Ala Ser Thr Phe Lys Ile Pro His Thr Leu
65 70 75 80
Phe Ala Leu Asp Ala Gly Ala Val Arg Asp Glu Phe Gln Ile Phe Arg
85 90 95
Trp Asp Gly Val Asn Arg Gly Phe Ala Gly His Asn Gln Asp Gln Asp
100 105 110
Leu Arg Ser Ala Met Arg Asn Ser Thr Val Trp Val Tyr Glu Leu Phe
115 120 125
Ala Lys Glu Ile Gly Asp Asp Lys Ala Arg Arg Tyr Leu Lys Lys Ile
130 135 140
Asp Tyr Gly Asn Ala Gly Pro Ser Thr Ser Asn Gly Asp Tyr Trp Ile
145 150 155 160
Glu Gly Ser Leu Ala Ile Ser Ala Gln Glu Gln Ile Ala Phe Leu Arg
165 170 175
Lys Leu Tyr Arg Asn Glu Leu Pro Phe Arg Val Glu His Gln Arg Leu
180 185 190
Val Lys Asp Leu Met Ile Val Glu Ala Gly Arg Asn Trp Ile Leu Arg
195 200 205
Ala Lys Thr Gly Trp Glu Gly Arg Met Gly Trp Trp Val Gly Trp Val
210 215 220
Glu Trp Pro Thr Gly Ser Val Phe Phe Ala Leu Asn Ile Asp Thr Pro
225 230 235 240
Asn Arg Met Asp Asp Leu Phe Lys Arg Glu Ala Ile Val Arg Ala Ile
245 250 255
Leu Arg Ser Ile Glu Ala Leu Pro Pro Asn Pro Ala Val Asn Ser Asp
260 265 270
Ala Ala Arg
275
<210> 351
<211> 275
<212> PRT
<213> RESISTANCE GENE
<400> 351
Met Gln Arg Ser Leu Ser Met Ser Gly Lys Arg His Phe Ile Phe Ala
1 5 10 15
Val Ser Phe Val Ile Ser Thr Val Cys Leu Thr Phe Ser Pro Ala Asn
20 25 30
Ala Ala Gln Lys Leu Ser Cys Thr Leu Val Ile Asp Glu Ala Ser Gly
35 40 45
Asp Leu Leu His Arg Glu Gly Ser Cys Asp Lys Ala Phe Ala Pro Met
50 55 60
Ser Thr Phe Lys Leu Pro Leu Ala Ile Met Gly Tyr Asp Ala Asp Ile
65 70 75 80
Leu Leu Asp Ala Thr Thr Pro Arg Trp Asp Tyr Lys Pro Glu Phe Asn
85 90 95
Gly Tyr Lys Ser Gln Gln Lys Pro Thr Asp Pro Thr Ile Trp Leu Lys
100 105 110
Asp Ser Ile Val Trp Tyr Ser Gln Glu Leu Thr Arg Arg Leu Gly Glu
115 120 125
Ser Arg Phe Ser Asp Tyr Val Gln Arg Phe Asp Tyr Gly Asn Lys Asp
130 135 140
Val Ser Gly Asp Pro Gly Lys His Asn Gly Leu Thr His Ala Trp Leu
145 150 155 160
Ala Ser Ser Leu Lys Ile Ser Pro Glu Glu Gln Val Arg Phe Leu Arg
165 170 175
Arg Phe Leu Arg Gly Glu Leu Pro Val Ser Glu Asp Ala Leu Glu Met
180 185 190
Thr Lys Ala Val Val Pro His Phe Glu Ala Gly Asp Trp Asp Val Gln
195 200 205
Gly Lys Thr Gly Thr Gly Ser Leu Ser Asp Ala Lys Gly Gly Lys Ala
210 215 220
Pro Ile Gly Trp Phe Ile Gly Trp Ala Thr Arg Asp Asp Arg Arg Val
225 230 235 240
Val Phe Ala Arg Leu Thr Val Gly Ala Arg Lys Gly Glu Gln Pro Ala
245 250 255
Gly Pro Ala Ala Arg Asp Glu Phe Leu Asn Thr Leu Pro Ala Leu Ser
260 265 270
Glu Asn Phe
275
<210> 352
<211> 266
<212> PRT
<213> RESISTANCE GENE
<400> 352
Met Lys Thr Phe Ala Ala Tyr Val Ile Ile Ala Cys Leu Ser Ser Thr
1 5 10 15
Ala Leu Ala Gly Ser Ile Thr Glu Asn Thr Ser Trp Asn Lys Glu Phe
20 25 30
Ser Ala Glu Ala Val Asn Gly Val Phe Val Leu Cys Lys Ser Ser Ser
35 40 45
Lys Ser Cys Ala Thr Asn Asp Leu Ala Arg Ala Ser Lys Glu Tyr Leu
50 55 60
Pro Ala Ser Thr Phe Lys Ile Pro Asn Ala Ile Ile Gly Leu Glu Thr
65 70 75 80
Gly Val Ile Lys Asn Glu His Gln Val Phe Lys Trp Asp Gly Lys Pro
85 90 95
Arg Ala Met Lys Gln Trp Glu Arg Asp Leu Thr Leu Arg Gly Ala Ile
100 105 110
Gln Val Ser Ala Val Pro Val Phe Gln Gln Ile Ala Arg Glu Val Gly
115 120 125
Glu Val Arg Met Gln Lys Tyr Leu Lys Lys Phe Ser Tyr Gly Asn Gln
130 135 140
Asn Ile Ser Gly Gly Ile Asp Lys Phe Trp Leu Glu Gly Gln Leu Arg
145 150 155 160
Ile Ser Ala Val Asn Gln Val Glu Phe Leu Glu Ser Leu Tyr Leu Asn
165 170 175
Lys Leu Ser Ala Ser Lys Glu Asn Gln Leu Ile Val Lys Glu Ala Leu
180 185 190
Val Thr Glu Ala Ala Pro Glu Tyr Leu Val His Ser Lys Thr Gly Phe
195 200 205
Ser Gly Val Gly Thr Glu Ser Asn Pro Gly Val Ala Trp Trp Val Gly
210 215 220
Trp Val Glu Lys Glu Thr Glu Val Tyr Phe Phe Ala Phe Asn Met Asp
225 230 235 240
Ile Asp Asn Glu Ser Lys Leu Pro Leu Arg Lys Ser Ile Pro Thr Lys
245 250 255
Ile Met Glu Ser Glu Gly Ile Ile Gly Gly
260 265
<210> 353
<211> 257
<212> PRT
<213> RESISTANCE GENE
<400> 353
Ile Ala Cys Leu Ser Ser Thr Ala Leu Ala Gly Ser Ile Thr Glu Asn
1 5 10 15
Thr Ser Trp Asn Lys Glu Phe Ser Ala Glu Ala Val Asn Gly Val Phe
20 25 30
Val Leu Cys Lys Ser Ser Ser Lys Ser Cys Ala Thr Asn Asp Leu Ala
35 40 45
Arg Ala Ser Lys Glu Tyr Leu Pro Ala Ser Thr Phe Lys Ile Pro Asn
50 55 60
Ala Ile Ile Gly Leu Glu Thr Gly Val Ile Lys Asn Glu His Gln Val
65 70 75 80
Phe Lys Trp Asp Gly Lys Pro Arg Ala Met Lys Gln Trp Glu Arg Asp
85 90 95
Leu Thr Leu Arg Gly Ala Ile Gln Val Ser Ala Val Pro Val Phe Gln
100 105 110
Gln Ile Thr Arg Glu Val Gly Glu Val Arg Met Gln Lys Tyr Leu Lys
115 120 125
Lys Phe Ser Tyr Gly Asn Gln Asn Ile Ser Gly Gly Ile Asp Lys Phe
130 135 140
Trp Leu Glu Asp Gln Leu Arg Ile Ser Ala Val Asn Gln Val Glu Phe
145 150 155 160
Leu Glu Ser Leu Tyr Leu Asn Lys Leu Ser Ala Ser Lys Glu Asn Gln
165 170 175
Leu Ile Val Lys Glu Ala Leu Val Thr Glu Ala Ala Pro Glu Tyr Leu
180 185 190
Val His Ser Lys Thr Gly Phe Ser Gly Val Gly Thr Glu Ser Asn Pro
195 200 205
Gly Val Ala Trp Trp Val Gly Trp Val Glu Lys Glu Thr Glu Val Tyr
210 215 220
Phe Phe Ala Phe Asn Met Asp Ile Asp Asn Glu Ser Lys Leu Pro Leu
225 230 235 240
Arg Lys Ser Ile Pro Thr Lys Ile Met Glu Ser Glu Gly Ile Ile Gly
245 250 255
Gly
<210> 354
<211> 257
<212> PRT
<213> RESISTANCE GENE
<400> 354
Ile Ala Cys Leu Ser Ser Thr Ala Leu Ala Gly Ser Ile Thr Glu Asn
1 5 10 15
Thr Ser Trp Asn Lys Glu Phe Ser Ala Glu Ala Val Asn Gly Val Phe
20 25 30
Val Leu Cys Lys Ser Ser Ser Lys Ser Cys Ala Thr Asn Asp Leu Ala
35 40 45
Arg Ala Ser Lys Glu Tyr Leu Pro Ala Ser Thr Phe Lys Ile Pro Ser
50 55 60
Ala Ile Ile Gly Leu Glu Thr Gly Val Ile Lys Asn Glu His Gln Val
65 70 75 80
Phe Lys Trp Asp Gly Lys Pro Arg Ala Met Lys Gln Trp Glu Arg Asp
85 90 95
Leu Thr Leu Arg Gly Ala Ile Gln Val Ser Ala Val Pro Val Phe Gln
100 105 110
Gln Ile Ala Arg Glu Val Gly Glu Val Arg Met Gln Lys Tyr Leu Lys
115 120 125
Lys Phe Ser Tyr Gly Asn Gln Asn Ile Ser Gly Gly Ile Asp Lys Phe
130 135 140
Trp Leu Glu Gly Gln Leu Arg Ile Ser Ala Val Asn Gln Val Glu Phe
145 150 155 160
Leu Glu Ser Leu Tyr Leu Asn Lys Leu Ser Ala Ser Lys Glu Asn Gln
165 170 175
Leu Ile Val Lys Glu Ala Leu Val Thr Glu Ala Ala Pro Glu Tyr Leu
180 185 190
Val His Ser Lys Thr Gly Phe Ser Gly Val Gly Thr Glu Ser Asn Pro
195 200 205
Gly Val Ala Trp Trp Val Gly Trp Val Glu Lys Glu Thr Glu Val Tyr
210 215 220
Phe Phe Ala Phe Asn Met Asp Ile Asp Asn Glu Ser Lys Leu Pro Leu
225 230 235 240
Arg Lys Ser Ile Pro Thr Lys Ile Met Glu Ser Glu Gly Ile Ile Gly
245 250 255
Gly
<210> 355
<211> 266
<212> PRT
<213> RESISTANCE GENE
<400> 355
Met Ile Ile Arg Phe Leu Ala Leu Leu Phe Ser Ala Val Val Leu Val
1 5 10 15
Ser Leu Gly His Ala Gln Glu Lys Thr His Glu Ser Ser Asn Trp Gly
20 25 30
Lys Tyr Phe Ser Asp Phe Asn Ala Lys Gly Thr Ile Val Val Val Asp
35 40 45
Glu Arg Thr Asn Gly Asn Ser Thr Ser Val Tyr Asn Glu Ser Arg Ala
50 55 60
Gln Gln Arg Tyr Ser Pro Ala Ser Thr Phe Lys Ile Pro His Thr Leu
65 70 75 80
Phe Ala Leu Asp Ala Gly Ala Val Arg Asp Glu Phe His Val Phe Arg
85 90 95
Trp Asp Gly Ala Lys Arg Ser Phe Ala Gly His Asn Gln Asp Gln Asn
100 105 110
Leu Arg Ser Ala Met Arg Asn Ser Thr Val Trp Val Tyr Gln Leu Phe
115 120 125
Ala Lys Glu Ile Gly Glu Asn Lys Ala Arg Ser Tyr Leu Glu Lys Leu
130 135 140
Asn Tyr Gly Asn Ala Asp Pro Ser Thr Lys Ser Gly Asp Tyr Trp Ile
145 150 155 160
Asp Gly Asn Leu Ala Ile Ser Ala Asn Glu Gln Ile Ser Ile Leu Lys
165 170 175
Lys Leu Tyr Arg Asn Glu Leu Pro Phe Arg Val Glu His Gln Arg Leu
180 185 190
Val Lys Asp Leu Met Ile Val Glu Ala Lys Arg Asp Trp Ile Leu Arg
195 200 205
Ala Lys Thr Gly Trp Asp Gly Gln Met Gly Trp Trp Val Gly Trp Val
210 215 220
Glu Trp Pro Thr Gly Pro Val Phe Phe Ala Leu Asn Ile Asp Thr Pro
225 230 235 240
Asn Arg Met Glu Asp Leu His Lys Arg Glu Ala Ile Ala Arg Ala Ile
245 250 255
Leu Gln Ser Val Asn Ala Leu Pro Pro Asn
260 265
<210> 356
<211> 275
<212> PRT
<213> RESISTANCE GENE
<400> 356
Met Ala Ile Arg Ile Phe Ala Ile Leu Phe Ser Thr Phe Val Phe Gly
1 5 10 15
Thr Phe Ala His Ala Gln Glu Gly Met Arg Glu Arg Ser Asp Trp Arg
20 25 30
Lys Phe Phe Ser Glu Phe Gln Ala Lys Gly Thr Ile Val Val Ala Asp
35 40 45
Glu Arg Gln Thr Asp Arg Val Ile Leu Val Phe Asp Gln Val Arg Ser
50 55 60
Glu Lys Arg Tyr Ser Pro Ala Ser Thr Phe Lys Ile Pro His Thr Leu
65 70 75 80
Phe Ala Leu Asp Ala Gly Ala Ala Arg Asp Glu Phe Gln Val Phe Arg
85 90 95
Trp Asp Gly Ile Lys Arg Ser Phe Ala Ala His Asn Gln Asp Gln Asp
100 105 110
Leu Arg Ser Ala Met Arg Asn Ser Thr Val Trp Ile Tyr Glu Leu Phe
115 120 125
Ala Lys Glu Ile Gly Glu Asp Lys Ala Arg Arg Tyr Leu Lys Gln Ile
130 135 140
Asp Tyr Gly Asn Ala Asp Pro Ser Thr Ser Asn Gly Asp Tyr Trp Ile
145 150 155 160
Asp Gly Asn Leu Ala Ile Ala Ala Gln Glu Gln Ile Ala Phe Leu Arg
165 170 175
Lys Leu Tyr His Asn Glu Leu Pro Phe Arg Val Glu His Gln Arg Leu
180 185 190
Val Lys Asp Leu Met Ile Val Glu Ala Gly Arg Asn Trp Ile Leu Arg
195 200 205
Ala Lys Thr Gly Trp Glu Gly Arg Ile Gly Trp Trp Val Gly Trp Val
210 215 220
Glu Trp Pro Thr Gly Pro Val Phe Phe Ala Leu Asn Ile Asp Thr Pro
225 230 235 240
Asn Arg Met Asp Asp Leu Phe Lys Arg Glu Ala Ile Val Arg Ala Ile
245 250 255
Leu Arg Ser Ile Glu Ala Leu Pro Pro Asn Pro Ala Val Asn Ser Asp
260 265 270
Ala Ala Arg
275
<210> 357
<211> 266
<212> PRT
<213> RESISTANCE GENE
<400> 357
Met Lys Thr Phe Ala Ala Tyr Val Ile Thr Ala Cys Leu Ser Ser Thr
1 5 10 15
Ala Leu Ala Ser Ser Ile Thr Glu Asn Thr Ser Trp Asn Lys Glu Phe
20 25 30
Ser Ala Glu Ala Val Asn Gly Val Phe Val Leu Cys Lys Ser Ser Ser
35 40 45
Lys Ser Cys Ala Thr Asn Asn Leu Ala Arg Ala Ser Lys Glu Tyr Leu
50 55 60
Pro Ala Ser Thr Phe Lys Ile Pro Ser Ala Ile Ile Gly Leu Glu Thr
65 70 75 80
Gly Val Ile Lys Asn Glu His Gln Val Phe Lys Trp Asp Gly Lys Pro
85 90 95
Arg Ala Met Lys Gln Trp Glu Arg Asp Leu Ser Leu Arg Gly Ala Ile
100 105 110
Gln Val Ser Ala Val Pro Val Phe Gln Gln Ile Ala Arg Glu Val Gly
115 120 125
Glu Val Arg Met Gln Lys Tyr Leu Lys Lys Phe Ser Tyr Gly Asn Gln
130 135 140
Asn Ile Ser Gly Gly Ile Asp Lys Phe Trp Leu Glu Gly Gln Leu Arg
145 150 155 160
Ile Ser Ala Val Asn Gln Val Glu Phe Leu Glu Ser Leu Phe Leu Asn
165 170 175
Lys Leu Ser Ala Ser Lys Glu Asn Gln Leu Ile Val Lys Glu Ala Leu
180 185 190
Val Thr Glu Ala Ala Pro Glu Tyr Leu Val His Ser Lys Thr Gly Phe
195 200 205
Ser Gly Val Gly Thr Glu Ser Asn Pro Gly Val Ala Trp Trp Val Gly
210 215 220
Trp Val Glu Lys Gly Thr Glu Val Tyr Phe Phe Ala Phe Asn Met Asp
225 230 235 240
Ile Asp Asn Glu Asn Lys Leu Pro Leu Arg Lys Ser Ile Pro Thr Lys
245 250 255
Ile Met Ala Ser Glu Gly Ile Ile Gly Gly
260 265
<210> 358
<211> 266
<212> PRT
<213> RESISTANCE GENE
<400> 358
Met Lys Thr Phe Ala Ala Tyr Val Ile Thr Ala Cys Leu Ser Ser Thr
1 5 10 15
Ala Leu Ala Ser Ser Ile Thr Glu Asn Thr Ser Trp Asn Lys Glu Phe
20 25 30
Ser Ala Glu Ala Val Asn Gly Val Phe Val Leu Cys Lys Ser Ser Ser
35 40 45
Lys Ser Cys Ala Thr Asn Asn Leu Ala Arg Ala Ser Lys Glu Tyr Leu
50 55 60
Pro Ala Ser Thr Phe Lys Ile Pro Asn Ala Ile Ile Gly Leu Glu Thr
65 70 75 80
Gly Val Ile Lys Asn Glu His Gln Val Phe Lys Trp Asp Gly Lys Pro
85 90 95
Arg Ala Met Lys Gln Trp Glu Arg Asp Leu Ser Leu Arg Gly Ala Ile
100 105 110
Gln Val Ser Ala Val Pro Val Phe Gln Gln Ile Ala Arg Glu Val Gly
115 120 125
Glu Val Arg Met Gln Lys Tyr Leu Lys Lys Phe Ser Tyr Gly Asn Gln
130 135 140
Asn Ile Ser Gly Gly Ile Asp Lys Phe Trp Leu Glu Asp Gln Leu Arg
145 150 155 160
Ile Ser Ala Val Asn Gln Val Glu Phe Leu Glu Ser Leu Phe Leu Asn
165 170 175
Lys Leu Ser Ala Ser Lys Glu Asn Gln Leu Ile Val Lys Glu Ala Leu
180 185 190
Val Thr Glu Ala Ala Pro Glu Tyr Leu Val His Ser Lys Thr Gly Phe
195 200 205
Ser Gly Val Gly Thr Glu Ser Asn Pro Gly Val Ala Trp Trp Val Gly
210 215 220
Trp Val Glu Lys Gly Thr Glu Val Tyr Phe Phe Ala Phe Asn Met Asp
225 230 235 240
Ile Asp Asn Glu Asn Lys Leu Pro Leu Arg Lys Ser Ile Pro Thr Lys
245 250 255
Ile Met Ala Ser Glu Gly Ile Ile Gly Gly
260 265
<210> 359
<211> 266
<212> PRT
<213> RESISTANCE GENE
<400> 359
Met Lys Thr Phe Ala Ala Tyr Val Ile Thr Ala Cys Leu Ser Ser Thr
1 5 10 15
Ala Leu Ala Ser Ser Ile Thr Glu Asn Thr Ser Trp Asn Lys Glu Phe
20 25 30
Ser Ala Glu Ala Val Asn Gly Val Phe Val Leu Cys Lys Ser Ser Ser
35 40 45
Lys Ser Cys Ala Thr Asn Asn Leu Ala Arg Ala Ser Lys Glu Tyr Leu
50 55 60
Pro Ala Ser Thr Phe Lys Ile Pro Asn Ala Ile Ile Gly Leu Glu Thr
65 70 75 80
Gly Val Ile Lys Asn Glu His Gln Val Phe Lys Trp Asp Gly Lys Pro
85 90 95
Arg Ala Met Lys Gln Trp Glu Arg Asp Leu Ser Leu Arg Gly Ala Ile
100 105 110
Gln Val Ser Ala Val Pro Val Phe Gln Gln Ile Ala Arg Glu Val Gly
115 120 125
Glu Val Arg Met Gln Lys Tyr Leu Lys Lys Phe Ser Tyr Gly Asn Gln
130 135 140
Asn Ile Ser Gly Gly Ile Asp Lys Phe Gly Leu Glu Gly Gln Leu Arg
145 150 155 160
Ile Ser Ala Val Asn Gln Val Glu Phe Leu Glu Ser Leu Phe Leu Asn
165 170 175
Lys Leu Ser Ala Ser Lys Glu Asn Gln Leu Ile Val Lys Glu Ala Leu
180 185 190
Val Thr Glu Ala Ala Pro Glu Tyr Leu Val His Ser Lys Thr Gly Phe
195 200 205
Ser Gly Val Gly Thr Glu Ser Asn Pro Gly Val Ala Trp Trp Val Gly
210 215 220
Trp Val Glu Lys Gly Thr Glu Val Tyr Phe Phe Ala Phe Asn Met Asp
225 230 235 240
Ile Asp Asn Glu Asn Lys Leu Pro Leu Arg Lys Ser Ile Pro Thr Lys
245 250 255
Ile Met Ala Ser Glu Gly Ile Ile Gly Gly
260 265
<210> 360
<211> 276
<212> PRT
<213> RESISTANCE GENE
<400> 360
Met Lys Asn Thr Ile His Ile Asn Phe Ala Ile Phe Leu Ile Ile Ala
1 5 10 15
Asn Ile Ile Tyr Ser Ser Ala Ser Ala Ser Thr Asp Ile Ser Thr Val
20 25 30
Ala Ser Pro Leu Phe Glu Gly Thr Glu Gly Cys Phe Leu Leu Tyr Asp
35 40 45
Ala Ser Thr Asn Ala Glu Ile Ala Gln Phe Asn Lys Ala Lys Cys Ala
50 55 60
Thr Gln Met Ala Pro Asp Ser Thr Phe Lys Ile Ala Leu Ser Leu Met
65 70 75 80
Ala Phe Asp Ala Glu Ile Ile Asp Gln Lys Thr Ile Phe Lys Trp Asp
85 90 95
Lys Thr Pro Lys Gly Met Glu Ile Trp Asn Ser Asn His Thr Pro Lys
100 105 110
Thr Trp Met Gln Phe Ser Val Val Trp Val Ser Gln Glu Ile Thr Gln
115 120 125
Lys Ile Gly Leu Asn Lys Ile Lys Asn Tyr Leu Lys Asp Phe Asp Tyr
130 135 140
Gly Asn Gln Asp Phe Ser Gly Asp Lys Glu Arg Asn Asn Gly Leu Thr
145 150 155 160
Glu Ala Trp Leu Glu Ser Ser Leu Lys Ile Ser Pro Glu Glu Gln Ile
165 170 175
Gln Phe Leu Arg Lys Ile Ile Asn His Asn Leu Pro Val Lys Asn Ser
180 185 190
Ala Ile Glu Asn Thr Ile Glu Asn Met Tyr Leu Gln Asp Leu Asp Asn
195 200 205
Ser Thr Lys Leu Tyr Gly Lys Thr Gly Ala Gly Phe Thr Ala Asn Arg
210 215 220
Thr Leu Gln Asn Gly Trp Phe Glu Gly Phe Ile Ile Ser Lys Ser Gly
225 230 235 240
His Lys Tyr Val Phe Val Ser Ala Leu Thr Gly Asn Leu Gly Ser Asn
245 250 255
Leu Thr Ser Ser Ile Lys Ala Lys Lys Asn Ala Ile Thr Ile Leu Asn
260 265 270
Thr Leu Asn Leu
275
<210> 361
<211> 256
<212> PRT
<213> RESISTANCE GENE
<400> 361
Ala Asn Ile Ile Tyr Ser Ser Ala Ser Ala Ser Thr Asp Ile Ser Thr
1 5 10 15
Val Ala Ser Pro Leu Phe Glu Gly Thr Glu Gly Cys Phe Leu Leu Tyr
20 25 30
Asp Val Ser Thr Asn Ala Glu Ile Ala Gln Phe Asn Lys Ala Lys Cys
35 40 45
Ala Thr Gln Met Ala Pro Asp Ser Thr Phe Lys Ile Ala Leu Ser Leu
50 55 60
Met Ala Phe Asp Ala Glu Ile Ile Asp Gln Lys Thr Ile Phe Lys Trp
65 70 75 80
Asp Lys Thr Pro Lys Gly Met Glu Ile Trp Asn Ser Asn His Thr Pro
85 90 95
Lys Thr Trp Met Gln Phe Ser Val Val Trp Val Ser Gln Glu Ile Thr
100 105 110
Gln Lys Ile Gly Leu Asn Lys Ile Lys Asn Tyr Leu Lys Asp Phe Asp
115 120 125
Tyr Gly Asn Gln Asp Phe Ser Gly Asp Lys Glu Arg Asn Asn Gly Leu
130 135 140
Thr Glu Ala Trp Leu Glu Ser Ser Leu Lys Ile Ser Pro Glu Glu Gln
145 150 155 160
Ile Gln Phe Leu Arg Lys Ile Ile Asn His Asn Leu Pro Val Lys Asn
165 170 175
Ser Ala Ile Glu Asn Thr Ile Glu Asn Met Tyr Leu Gln Asp Leu Glu
180 185 190
Asn Ser Thr Lys Leu Tyr Gly Lys Thr Gly Ala Gly Phe Thr Ala Asn
195 200 205
Arg Thr Leu Gln Asn Gly Trp Phe Glu Gly Phe Ile Ile Ser Lys Ser
210 215 220
Gly His Lys Tyr Val Phe Val Ser Ala Leu Thr Gly Asn Leu Gly Ser
225 230 235 240
Asn Leu Thr Ser Ser Ile Lys Ala Lys Lys Asn Ala Ile Thr Ile Leu
245 250 255
<210> 362
<211> 246
<212> PRT
<213> RESISTANCE GENE
<400> 362
Ile Phe Ser Leu Ala Thr Phe Ala His Ala Gln Glu Gly Thr Leu Glu
1 5 10 15
Arg Ser Asp Trp Arg Lys Phe Phe Ser Glu Phe Gln Ala Lys Gly Thr
20 25 30
Ile Val Val Ala Asp Glu Arg Gln Ala Asp Arg Ala Met Leu Val Phe
35 40 45
Asp Pro Val Arg Ser Lys Lys Arg Tyr Ser Pro Ala Ser Thr Phe Lys
50 55 60
Ile Pro His Thr Leu Phe Ala Leu Asp Ala Gly Ala Val Arg Asp Glu
65 70 75 80
Phe Gln Ile Phe Arg Trp Asp Gly Val Asn Arg Gly Phe Ala Gly His
85 90 95
Asn Gln Asp Gln Asp Leu Arg Ser Ala Met Arg Asn Ser Thr Val Trp
100 105 110
Val Tyr Glu Leu Phe Ala Lys Glu Ile Gly Asp Asp Lys Ala Arg Arg
115 120 125
Tyr Leu Lys Lys Ile Asp Tyr Gly Asn Ala Tyr Pro Ser Thr Ser Asn
130 135 140
Gly Asp Tyr Trp Ile Glu Gly Ser Leu Ala Ile Ser Ala Gln Glu Gln
145 150 155 160
Ile Ala Phe Leu Arg Lys Leu Tyr Arg Asn Glu Leu Pro Phe Arg Val
165 170 175
Glu His Gln Arg Leu Val Lys Asp Leu Met Ile Val Glu Ala Gly Arg
180 185 190
Asn Trp Ile Leu Arg Ala Lys Thr Gly Trp Glu Gly Arg Met Gly Trp
195 200 205
Trp Val Gly Trp Val Glu Trp Pro Thr Gly Ser Val Phe Phe Ala Leu
210 215 220
Asn Ile Asp Thr Pro Asn Arg Met Asp Asp Leu Phe Lys Arg Glu Ala
225 230 235 240
Ile Val Arg Ala Ile Leu
245
<210> 363
<211> 266
<212> PRT
<213> RESISTANCE GENE
<400> 363
Met Ile Ile Arg Phe Leu Ala Leu Leu Phe Ser Ala Val Val Leu Val
1 5 10 15
Ser Leu Gly His Ala Gln Asp Lys Thr His Glu Ser Ser Asn Trp Gly
20 25 30
Lys Tyr Phe Ser Asp Phe Asn Ala Lys Gly Thr Ile Val Val Val Asp
35 40 45
Glu Arg Thr Asn Gly Asn Ser Thr Ser Val Tyr Asn Glu Ser Arg Ala
50 55 60
Gln Gln Arg Tyr Ser Pro Ala Ser Thr Phe Lys Ile Pro His Thr Leu
65 70 75 80
Phe Ala Leu Asp Ala Gly Ala Val Arg Asp Glu Phe His Val Phe Arg
85 90 95
Trp Asp Gly Ala Lys Arg Ser Phe Ala Gly His Asn Gln Asp Gln Asn
100 105 110
Leu Arg Ser Ala Met Arg Asn Ser Thr Val Trp Val Tyr Gln Leu Phe
115 120 125
Ala Lys Glu Ile Gly Glu Asn Lys Ala Arg Ser Tyr Leu Glu Lys Leu
130 135 140
Asn Tyr Gly Asn Ala Asp Pro Ser Thr Lys Ser Gly Asp Tyr Trp Ile
145 150 155 160
Asp Gly Asn Leu Ala Ile Ser Ala Asn Glu Gln Ile Ser Ile Leu Lys
165 170 175
Lys Leu Tyr Arg Asn Glu Leu Pro Phe Arg Val Glu His Gln Arg Leu
180 185 190
Val Lys Asp Leu Met Ile Val Glu Ala Lys Arg Asp Trp Ile Leu Arg
195 200 205
Ala Lys Thr Gly Trp Asp Gly Gln Met Gly Trp Trp Val Gly Trp Val
210 215 220
Glu Trp Pro Thr Gly Pro Val Phe Phe Ala Leu Asn Ile Asp Thr Pro
225 230 235 240
Asn Arg Met Glu Asp Leu His Lys Arg Glu Ala Ile Ala Arg Ala Ile
245 250 255
Leu Gln Ser Val Asn Ala Leu Pro Pro Asn
260 265
<210> 364
<211> 275
<212> PRT
<213> RESISTANCE GENE
<400> 364
Met Lys Lys Phe Ile Leu Pro Ile Phe Ser Ile Ser Ile Leu Val Ser
1 5 10 15
Leu Ser Ala Cys Ser Ser Ile Lys Thr Lys Ser Glu Asp Asn Phe His
20 25 30
Ile Ser Ser Gln Gln His Glu Lys Ala Ile Lys Ser Tyr Phe Asp Glu
35 40 45
Ala Gln Thr Gln Gly Val Ile Ile Ile Lys Glu Gly Lys Asn Leu Ser
50 55 60
Thr Tyr Gly Asn Ala Leu Ala Arg Ala Asn Lys Glu Tyr Val Pro Ala
65 70 75 80
Ser Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu Asn His Lys
85 90 95
Ala Thr Thr Asn Glu Ile Phe Lys Trp Asp Gly Lys Lys Arg Thr Tyr
100 105 110
Pro Met Trp Glu Lys Asp Met Thr Leu Gly Glu Ala Met Ala Leu Ser
115 120 125
Ala Val Pro Val Tyr Gln Glu Leu Ala Arg Arg Thr Gly Leu Glu Leu
130 135 140
Met Gln Lys Glu Val Lys Arg Val Asn Phe Gly Asn Thr Asn Ile Gly
145 150 155 160
Thr Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro
165 170 175
Val Gln Glu Val Asn Phe Ala Asp Asp Leu Ala His Asn Arg Leu Pro
180 185 190
Phe Lys Leu Glu Thr Gln Glu Glu Val Glu Lys Met Leu Leu Ile Lys
195 200 205
Glu Val Asn Gly Ser Lys Ile Tyr Ala Lys Ser Gly Trp Gly Met Gly
210 215 220
Val Thr Pro Gln Val Gly Trp Leu Thr Gly Trp Val Glu Gln Ala Asn
225 230 235 240
Gly Lys Lys Ile Pro Phe Ser Leu Asn Leu Glu Met Lys Glu Gly Met
245 250 255
Ser Gly Ser Ile Arg Asn Glu Ile Thr Tyr Lys Leu Leu Glu Asn Leu
260 265 270
Gly Ile Ile
275
<210> 365
<211> 275
<212> PRT
<213> RESISTANCE GENE
<400> 365
Met Lys Lys Phe Ile Leu Pro Ile Phe Ser Ile Ser Ile Leu Val Ser
1 5 10 15
Leu Ser Ala Cys Ser Ser Ile Lys Thr Lys Ser Glu Asp Asn Phe His
20 25 30
Ile Ser Ser Gln Gln His Glu Lys Ala Ile Lys Ser Tyr Phe Asp Glu
35 40 45
Ala Gln Thr Gln Gly Val Ile Ile Ile Lys Glu Gly Lys Asn Leu Ser
50 55 60
Thr Tyr Gly Asn Ala Leu Ala Arg Ala Asn Lys Glu Tyr Val Pro Ala
65 70 75 80
Ser Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu Asn His Lys
85 90 95
Ala Thr Thr Asn Glu Ile Phe Lys Trp Asp Gly Lys Lys Arg Thr Tyr
100 105 110
Pro Met Trp Glu Lys Asp Met Thr Leu Gly Glu Ala Met Ala Leu Ser
115 120 125
Ala Val Pro Val Tyr Gln Glu Leu Ala Arg Arg Thr Gly Leu Glu Leu
130 135 140
Met Gln Lys Glu Val Lys Arg Val Asn Phe Gly Asn Thr Asn Ile Gly
145 150 155 160
Thr Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro
165 170 175
Val Gln Glu Val Asn Phe Ala Asp Asp Leu Ala His Asn Arg Leu Pro
180 185 190
Phe Lys Leu Glu Thr Gln Glu Glu Val Lys Lys Met Leu Leu Ile Lys
195 200 205
Glu Val Asn Gly Ser Lys Ile Tyr Ala Lys Ser Gly Trp Gly Met Gly
210 215 220
Val Thr Pro Gln Val Gly Trp Leu Thr Gly Trp Val Glu Gln Ala Asn
225 230 235 240
Gly Lys Lys Ile Pro Phe Ser Leu Asn Leu Glu Met Lys Glu Gly Met
245 250 255
Thr Gly Ser Ile Arg Asn Glu Ile Thr Tyr Lys Ser Leu Glu Asn Leu
260 265 270
Gly Ile Ile
275
<210> 366
<211> 273
<212> PRT
<213> RESISTANCE GENE
<400> 366
Met Asn Lys Tyr Phe Thr Cys Tyr Val Val Ala Ser Leu Phe Leu Ser
1 5 10 15
Gly Cys Thr Val Gln His Asn Leu Ile Asn Glu Thr Pro Ser Gln Ile
20 25 30
Val Gln Gly His Asn Gln Val Ile His Gln Tyr Phe Asp Glu Lys Asn
35 40 45
Thr Ser Gly Val Leu Val Ile Gln Thr Asp Lys Lys Ile Asn Leu Tyr
50 55 60
Gly Asn Ala Leu Ser Arg Ala Asn Thr Glu Tyr Val Pro Ala Ser Thr
65 70 75 80
Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu Asn Gln Lys Ala Asp
85 90 95
Ile Asn Glu Ile Phe Lys Trp Lys Gly Glu Lys Arg Ser Phe Thr Ala
100 105 110
Trp Glu Lys Asp Met Thr Leu Gly Glu Ala Met Lys Leu Ser Ala Val
115 120 125
Pro Val Tyr Gln Glu Leu Ala Arg Arg Ile Gly Leu Asp Leu Met Gln
130 135 140
Lys Glu Val Lys Arg Ile Gly Phe Gly Asn Ala Glu Ile Gly Gln Gln
145 150 155 160
Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Val Thr Pro Ile Gln
165 170 175
Glu Val Glu Phe Val Ser Gln Leu Ala His Thr Gln Leu Pro Phe Ser
180 185 190
Glu Lys Val Gln Ala Asn Val Lys Asn Met Leu Leu Leu Glu Glu Ser
195 200 205
Asn Gly Tyr Lys Ile Phe Gly Lys Thr Gly Trp Ala Met Asp Ile Lys
210 215 220
Pro Gln Val Gly Trp Leu Thr Gly Trp Val Glu Gln Pro Asp Gly Lys
225 230 235 240
Ile Val Ala Phe Ala Leu Lys Met Glu Met Arg Ser Glu Met Pro Ala
245 250 255
Ser Ile Arg Asn Glu Leu Leu Met Lys Ser Leu Lys Gln Leu Asn Ile
260 265 270
Ile
<210> 367
<211> 257
<212> PRT
<213> RESISTANCE GENE
<400> 367
Met Ala Ile Arg Ile Phe Ala Ile Leu Phe Ser Ile Phe Ser Leu Ala
1 5 10 15
Thr Phe Ala His Ala Gln Glu Gly Thr Leu Glu Arg Ser Asp Trp Arg
20 25 30
Lys Phe Phe Ser Glu Phe Gln Ala Lys Gly Thr Ile Val Val Ala Asp
35 40 45
Glu Arg Gln Ala Asp Arg Ala Met Leu Val Phe Asp Pro Val Arg Ser
50 55 60
Lys Lys Arg Tyr Ser Pro Ala Ser Thr Phe Lys Ile Pro His Thr Leu
65 70 75 80
Phe Ala Leu Asp Ala Gly Ala Val Arg Asp Glu Phe Gln Ile Phe Arg
85 90 95
Trp Asp Gly Val Asn Arg Gly Phe Ala Gly His Asn Gln Asp Gln Asp
100 105 110
Leu Arg Ser Ala Met Arg Asn Ser Thr Val Trp Val Tyr Glu Leu Phe
115 120 125
Ala Lys Glu Ile Gly Asp Asp Lys Ala Arg Arg Tyr Leu Lys Lys Ile
130 135 140
Asp Tyr Gly Asn Ala Asp Pro Ser Thr Ser Asn Gly Asp Tyr Cys Ile
145 150 155 160
Glu Gly Ser Leu Ala Ile Ser Ala Gln Glu Gln Ile Ala Phe Leu Arg
165 170 175
Lys Leu Tyr Arg Asn Glu Leu Pro Phe Arg Val Glu His Gln Arg Leu
180 185 190
Val Lys Asp Leu Met Ile Val Glu Ala Gly Arg Asn Trp Ile Leu Arg
195 200 205
Ala Lys Thr Gly Trp Glu Gly Arg Met Gly Trp Trp Val Gly Trp Val
210 215 220
Glu Trp Pro Thr Gly Ser Val Phe Phe Ala Leu Asn Ile Asp Thr Pro
225 230 235 240
Asn Arg Met Asp Asp Leu Phe Lys Arg Glu Ala Ile Val Arg Ala Ile
245 250 255
Leu
<210> 368
<211> 266
<212> PRT
<213> RESISTANCE GENE
<400> 368
Met Lys Thr Phe Ala Ala Tyr Val Ile Thr Ala Cys Leu Ser Ser Thr
1 5 10 15
Ala Leu Ala Ser Ser Ile Thr Glu Asn Thr Ser Trp Asn Lys Glu Phe
20 25 30
Ser Ala Glu Ala Val Asn Gly Val Phe Val Leu Cys Lys Ser Ser Ser
35 40 45
Lys Ser Cys Ala Thr Asn Asn Leu Ala Arg Ala Ser Lys Glu Tyr Leu
50 55 60
Pro Ala Ser Thr Phe Lys Ile Pro Asn Ala Ile Ile Gly Leu Glu Thr
65 70 75 80
Gly Val Ile Lys Asn Glu His Gln Val Phe Lys Trp Asp Gly Lys Pro
85 90 95
Arg Ala Met Lys Gln Trp Glu Arg Asp Leu Ser Leu Arg Gly Ala Ile
100 105 110
Gln Val Ser Ala Val Pro Val Phe Gln Gln Ile Ala Arg Glu Val Gly
115 120 125
Glu Val Arg Met Gln Lys Tyr Leu Lys Lys Phe Ser Tyr Gly Asn Gln
130 135 140
Asn Ile Ser Gly Gly Ile Asp Lys Phe Trp Leu Glu Gly Gln Leu Arg
145 150 155 160
Ile Ser Ala Val Asn Gln Val Glu Phe Leu Glu Ser Leu Phe Leu Asn
165 170 175
Lys Leu Ser Ala Ser Lys Glu Asn Gln Leu Ile Val Lys Glu Ala Leu
180 185 190
Val Thr Glu Ala Ala Pro Glu Tyr Leu Val His Ser Lys Thr Gly Phe
195 200 205
Ser Gly Val Gly Thr Glu Ser Asn Pro Gly Val Ala Trp Trp Val Gly
210 215 220
Trp Val Glu Lys Gly Thr Glu Val Tyr Phe Phe Ala Phe Asn Met Asp
225 230 235 240
Ile Asp Asn Glu Asn Lys Leu Pro Leu Arg Lys Ser Ile Pro Thr Lys
245 250 255
Ile Met Ala Ser Glu Gly Ile Ile Gly Gly
260 265
<210> 369
<211> 266
<212> PRT
<213> RESISTANCE GENE
<400> 369
Met Ala Ile Arg Phe Leu Thr Ile Leu Leu Ser Thr Phe Phe Leu Thr
1 5 10 15
Ser Phe Val His Ala Gln Glu His Val Leu Glu Arg Ser Asp Trp Lys
20 25 30
Lys Phe Phe Ser Asp Leu Arg Ala Glu Gly Ala Ile Val Ile Ser Asp
35 40 45
Glu Arg Gln Ala Glu His Ala Leu Leu Val Phe Gly Gln Glu Arg Ala
50 55 60
Ala Lys Arg Tyr Ser Pro Ala Ser Thr Phe Lys Leu Pro His Thr Leu
65 70 75 80
Phe Ala Leu Asp Ala Asp Ala Val Arg Asp Glu Phe Gln Val Phe Arg
85 90 95
Trp Asp Gly Val Lys Arg Ser Phe Ala Gly His Asn Gln Asp Gln Asp
100 105 110
Leu Arg Ser Ala Met Arg Asn Ser Ala Val Trp Val Tyr Glu Leu Phe
115 120 125
Ala Lys Glu Ile Gly Lys Asp Lys Ala Arg His Tyr Leu Lys Gln Ile
130 135 140
Asp Tyr Gly Asn Ala Asp Pro Ser Thr Ile Lys Gly Asp Tyr Trp Ile
145 150 155 160
Asp Gly Asn Leu Glu Ile Ser Ala His Glu Gln Ile Ser Phe Leu Arg
165 170 175
Lys Leu Tyr Arg Asn Gln Leu Pro Phe Gln Val Glu His Gln Arg Leu
180 185 190
Val Lys Asp Leu Met Ile Thr Glu Ala Gly Arg Asn Trp Ile Leu Arg
195 200 205
Ala Lys Thr Gly Trp Glu Gly Arg Phe Gly Trp Trp Val Gly Trp Val
210 215 220
Glu Trp Pro Thr Gly Pro Val Phe Phe Ala Leu Asn Ile Asp Thr Pro
225 230 235 240
Asn Arg Thr Asp Asp Leu Phe Lys Arg Glu Ala Ile Ala Arg Ala Ile
245 250 255
Leu Arg Ser Ile Asp Ala Leu Pro Pro Asn
260 265
<210> 370
<211> 275
<212> PRT
<213> RESISTANCE GENE
<400> 370
Met Ala Ile Arg Ile Phe Ala Ile Leu Phe Ser Ile Phe Ser Leu Ala
1 5 10 15
Thr Phe Ala His Ala Gln Glu Gly Thr Leu Glu Arg Ser Asp Trp Arg
20 25 30
Lys Phe Phe Ser Glu Phe Gln Ala Lys Gly Thr Ile Val Val Ala Asp
35 40 45
Glu Arg Gln Ala Asp Arg Ala Met Leu Val Phe Asp Pro Val Arg Ser
50 55 60
Lys Lys Arg Tyr Ser Pro Ala Ser Thr Phe Lys Ile Pro His Thr Leu
65 70 75 80
Phe Ala Leu Asp Ala Gly Ala Val Arg Asp Glu Phe Gln Ile Phe Arg
85 90 95
Trp Asp Gly Val Asn Arg Gly Phe Ala Gly His Asn Gln Asp Gln Asp
100 105 110
Leu Arg Ser Ala Met Arg Asn Ser Thr Val Trp Val Tyr Glu Leu Phe
115 120 125
Ala Lys Glu Ile Gly Asp Asp Lys Ala Arg Arg Tyr Leu Lys Lys Ile
130 135 140
Asp Tyr Gly Asn Ala Asp Pro Ser Thr Ser Asn Gly Asp Tyr Trp Ile
145 150 155 160
Glu Gly Ser Ile Ala Ile Ser Ala Gln Glu Gln Ile Ala Phe Leu Arg
165 170 175
Lys Leu Tyr Arg Asn Glu Leu Pro Phe Arg Val Glu His Gln Arg Leu
180 185 190
Val Lys Asp Leu Met Ile Val Glu Ala Gly Arg Asn Trp Ile Leu Arg
195 200 205
Ala Lys Thr Gly Trp Glu Gly Arg Met Gly Trp Trp Val Gly Trp Val
210 215 220
Glu Trp Pro Thr Gly Ser Val Phe Phe Ala Leu Asn Ile Asp Thr Pro
225 230 235 240
Asn Arg Met Asp Asp Leu Phe Lys Arg Glu Ala Ile Val Arg Ala Ile
245 250 255
Leu Arg Ser Ile Glu Ala Leu Pro Pro Asn Pro Ala Val Asn Ser Asp
260 265 270
Ala Ala Arg
275
<210> 371
<211> 275
<212> PRT
<213> RESISTANCE GENE
<400> 371
Met Lys Lys Phe Ile Leu Pro Ile Phe Ser Ile Ser Ile Leu Val Ser
1 5 10 15
Leu Ser Ala Cys Ser Ser Ile Lys Thr Lys Ser Glu Asp Asn Phe His
20 25 30
Ile Ser Ser Gln Gln His Glu Lys Ala Ile Lys Ser Tyr Phe Asp Glu
35 40 45
Ala Gln Thr Gln Gly Val Ile Ile Ile Lys Glu Gly Lys Asn Leu Ser
50 55 60
Thr Tyr Gly Asn Ala Leu Ala Arg Ala Asn Lys Glu Tyr Val Pro Ala
65 70 75 80
Ser Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu Asn His Lys
85 90 95
Ala Thr Thr Asn Glu Ile Phe Lys Trp Asp Gly Lys Lys Arg Thr Tyr
100 105 110
Pro Met Trp Glu Lys Asp Met Thr Leu Gly Glu Ala Met Ala Leu Ser
115 120 125
Ala Val Pro Val Tyr Gln Glu Leu Ala Arg Arg Thr Gly Leu Glu Leu
130 135 140
Met Gln Lys Glu Val Lys Arg Val Asn Phe Gly Asn Thr Asn Ile Gly
145 150 155 160
Thr Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro
165 170 175
Val Gln Glu Val Asn Phe Ala Asp Asp Leu Ala His Asn Arg Leu Pro
180 185 190
Phe Lys Leu Glu Thr Gln Glu Glu Val Lys Lys Met Leu Leu Ile Lys
195 200 205
Glu Val Asn Gly Ser Lys Ile Tyr Ala Lys Ser Gly Trp Gly Met Gly
210 215 220
Val Thr Pro Gln Val Gly Trp Leu Thr Gly Trp Val Glu Gln Ala Asn
225 230 235 240
Gly Lys Lys Ile Pro Phe Ser Leu Asn Leu Glu Met Lys Glu Gly Met
245 250 255
Ser Gly Ser Ile Arg Asn Glu Ile Thr Tyr Lys Ser Leu Glu Asn Leu
260 265 270
Gly Ile Ile
275
<210> 372
<211> 266
<212> PRT
<213> RESISTANCE GENE
<400> 372
Met Ala Ile Arg Phe Leu Thr Ile Leu Leu Ser Thr Phe Phe Leu Thr
1 5 10 15
Ser Phe Val His Ala Gln Glu His Val Leu Glu Arg Ser Asp Trp Lys
20 25 30
Lys Phe Phe Ser Asp Leu Arg Ala Glu Gly Ala Ile Val Ile Ser Asp
35 40 45
Glu Arg Gln Ala Glu His Ala Leu Leu Val Phe Gly Gln Glu Arg Ala
50 55 60
Ala Lys Arg Tyr Ser Pro Ala Ser Thr Phe Lys Leu Pro His Thr Leu
65 70 75 80
Phe Ala Leu Asp Ala Asp Ala Val Arg Asp Glu Phe Gln Val Phe Arg
85 90 95
Trp Asp Gly Val Lys Arg Ser Phe Ala Gly His Asn Gln Asp Gln Asp
100 105 110
Leu Arg Ser Ala Met Arg Asn Ser Ala Val Trp Val Tyr Glu Leu Phe
115 120 125
Ala Lys Glu Ile Gly Glu Asp Lys Ala Arg Arg Tyr Leu Lys Gln Ile
130 135 140
Asp Tyr Gly Asn Ala Asp Pro Ser Thr Ile Lys Gly Asp Tyr Trp Ile
145 150 155 160
Asp Gly Asn Leu Glu Ile Ser Ala His Glu Gln Ile Ser Phe Leu Arg
165 170 175
Lys Leu Tyr Arg Asn Gln Leu Pro Phe Gln Val Glu His Gln Arg Leu
180 185 190
Val Lys Asp Leu Met Ile Thr Glu Ala Gly Arg Asn Trp Ile Leu Arg
195 200 205
Ala Lys Thr Gly Trp Glu Gly Arg Phe Gly Trp Trp Val Gly Trp Val
210 215 220
Glu Trp Pro Thr Gly Pro Val Phe Phe Ala Leu Asn Ile Asp Thr Pro
225 230 235 240
Asn Arg Thr Asp Asp Leu Phe Lys Arg Glu Ala Ile Ala Arg Ala Ile
245 250 255
Leu Arg Ser Ile Asp Ala Leu Pro Pro Asn
260 265
<210> 373
<211> 266
<212> PRT
<213> RESISTANCE GENE
<400> 373
Met Ala Ile Arg Phe Phe Thr Ile Leu Leu Ser Thr Phe Phe Leu Thr
1 5 10 15
Ser Phe Val Tyr Ala Gln Glu His Val Val Ile Arg Ser Asp Trp Lys
20 25 30
Lys Phe Phe Ser Asp Leu Gln Ala Glu Gly Ala Ile Val Ile Ala Asp
35 40 45
Glu Arg Gln Ala Lys His Thr Leu Ser Val Phe Asp Gln Glu Arg Ala
50 55 60
Ala Lys Arg Tyr Ser Pro Ala Ser Thr Phe Lys Ile Pro His Thr Leu
65 70 75 80
Phe Ala Leu Asp Ala Asp Ala Val Arg Asp Glu Phe Gln Val Phe Arg
85 90 95
Trp Asp Gly Val Asn Arg Ser Phe Ala Gly His Asn Gln Asp Gln Asp
100 105 110
Leu Arg Ser Ala Met Arg Asn Ser Thr Val Trp Val Tyr Glu Leu Phe
115 120 125
Ala Lys Asp Ile Gly Glu Asp Lys Ala Arg Arg Tyr Leu Lys Gln Ile
130 135 140
Asp Tyr Gly Asn Val Asp Pro Ser Thr Ile Lys Gly Asp Tyr Trp Ile
145 150 155 160
Asp Gly Asn Leu Lys Ile Ser Ala His Glu Gln Ile Leu Phe Leu Arg
165 170 175
Lys Leu Tyr Arg Asn Gln Leu Pro Phe Lys Val Glu His Gln Arg Leu
180 185 190
Val Lys Asp Leu Met Ile Thr Glu Ala Gly Arg Ser Trp Ile Leu Arg
195 200 205
Ala Lys Thr Gly Trp Glu Gly Arg Phe Gly Trp Trp Val Gly Trp Ile
210 215 220
Glu Trp Pro Thr Gly Pro Val Phe Phe Ala Leu Asn Ile Asp Thr Pro
225 230 235 240
Asn Arg Thr Asp Asp Leu Phe Lys Arg Glu Ala Ile Ala Arg Ala Ile
245 250 255
Leu Arg Ser Ile Asp Ala Leu Pro Pro Asn
260 265
<210> 374
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 374
Met Asn Lys Tyr Phe Thr Cys Tyr Val Val Ala Ser Leu Phe Leu Ser
1 5 10 15
Gly Cys Thr Val Gln His Asn Leu Ile Asn Glu Thr Pro Ser Gln Ile
20 25 30
Val Gln Gly His Asn Gln Val Ile His Gln Tyr Phe Asp Glu Lys Asn
35 40 45
Thr Ser Gly Val Leu Val Ile Gln Thr Asp Lys Lys Ile Asn Leu Tyr
50 55 60
Gly Asn Ala Leu Ser Arg Ala Asn Thr Glu Tyr Val Pro Ala Ser Thr
65 70 75 80
Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu Asn Gln Lys Thr Asp
85 90 95
Ile Asn Glu Ile Phe Lys Trp Lys Gly Glu Lys Arg Ser Phe Thr Ala
100 105 110
Trp Glu Lys Asp Met Thr Leu Gly Glu Ala Met Lys Leu Ser Ala Val
115 120 125
Pro Val Tyr Gln Glu Leu Ala Arg Arg Ile Gly Leu Asp Leu Met Gln
130 135 140
Lys Glu Val Glu Arg Ile Gly Phe Gly Asn Ala Glu Ile Gly Gln Gln
145 150 155 160
Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Val Thr Pro Ile Gln
165 170 175
Glu Val Glu Phe Val Ser Gln Leu Ala His Thr Gln Leu Pro Phe Ser
180 185 190
Glu Lys Val Gln Ala Asn Val Lys Asn Met Leu Leu Leu Glu Glu Ser
195 200 205
Asn Gly Tyr Lys Ile Phe Gly Lys Thr Gly Trp Ala Ala Met Asp Ile
210 215 220
Lys Pro Gln Val Gly Trp Leu Thr Gly Trp Val Glu Gln Pro Asp Gly
225 230 235 240
Lys Ile Val Ala Phe Ala Leu Asn Met Glu Met Arg Ser Glu Met Pro
245 250 255
Ala Ser Ile Arg Asn Glu Leu Leu Met Lys Ser Leu Lys Gln Leu Asn
260 265 270
Ile Ile
<210> 375
<211> 275
<212> PRT
<213> RESISTANCE GENE
<400> 375
Met Ala Ile Gln Ile Phe Ala Ile Leu Phe Ser Thr Phe Val Leu Ala
1 5 10 15
Thr Phe Ala His Ala Gln Asp Gly Thr Leu Glu Arg Ser Asp Trp Gly
20 25 30
Lys Phe Phe Ser Asp Phe Gln Ala Lys Gly Thr Ile Val Val Ala Asp
35 40 45
Glu Arg Gln Ala Asp His Ala Ile Leu Val Phe Asp Gln Ala Arg Ser
50 55 60
Met Lys Arg Tyr Ser Pro Ala Ser Thr Phe Lys Ile Pro His Thr Leu
65 70 75 80
Phe Ala Leu Asp Ala Gly Ala Val Arg Asp Glu Phe Gln Ile Phe Arg
85 90 95
Trp Asp Gly Val Lys Arg Ser Phe Ala Gly His Asn Lys Asp Gln Asp
100 105 110
Leu Arg Ser Ala Met Arg Asn Ser Thr Val Trp Val Tyr Glu Leu Phe
115 120 125
Ala Lys Glu Ile Gly Asp Gly Lys Ala Arg Arg Tyr Leu Lys Gln Ile
130 135 140
Gly Tyr Gly Asn Ala Asp Pro Ser Thr Ser His Gly Asp Tyr Trp Ile
145 150 155 160
Glu Gly Ser Leu Ala Ile Ser Ala Gln Glu Gln Ile Ala Phe Leu Arg
165 170 175
Lys Leu Tyr Gln Asn Asp Leu Pro Phe Arg Val Glu His Gln Arg Leu
180 185 190
Val Lys Asp Leu Met Ile Val Glu Ala Gly Arg Asn Trp Ile Leu Arg
195 200 205
Ala Lys Thr Gly Trp Glu Gly Ser Met Gly Trp Trp Val Gly Trp Val
210 215 220
Glu Trp Pro Thr Gly Pro Val Phe Phe Ala Leu Asn Ile Asp Thr Pro
225 230 235 240
Asn Arg Met Asp Asp Leu Phe Lys Arg Glu Ala Ile Ala Arg Ala Ile
245 250 255
Leu Leu Ser Ile Glu Ala Leu Pro Pro Asn Pro Ala Val His Ser Asp
260 265 270
Ala Ala Arg
275
<210> 376
<211> 276
<212> PRT
<213> RESISTANCE GENE
<400> 376
Met Lys Asn Thr Ile His Ile Asn Phe Ala Ile Phe Leu Ile Ile Ala
1 5 10 15
Asn Ile Ile Tyr Ser Ser Ala Ser Ala Ser Thr Asp Ile Ser Thr Val
20 25 30
Ala Ser Gln Leu Phe Glu Gly Thr Glu Gly Cys Phe Leu Leu Tyr Asp
35 40 45
Ala Ser Thr Asn Ala Glu Ile Ala Gln Phe Asn Lys Ala Lys Cys Ala
50 55 60
Ala Gln Met Ala Pro Asp Ser Thr Phe Lys Ile Ala Leu Ser Leu Met
65 70 75 80
Ala Phe Asp Ala Glu Ile Ile Asp Gln Lys Thr Ile Phe Lys Trp Asp
85 90 95
Lys Ile Pro Lys Gly Met Glu Ile Trp Asn Ser Asn His Thr Pro Lys
100 105 110
Thr Trp Met Gln Phe Ser Val Val Trp Val Ser Gln Glu Ile Thr Gln
115 120 125
Lys Ile Gly Leu Asn Lys Ile Lys Asn Tyr Leu Lys Asp Phe Asp Tyr
130 135 140
Gly Asn Gln Asp Phe Ser Gly Asp Lys Glu Arg Asn Asn Gly Leu Thr
145 150 155 160
Glu Ala Trp Leu Glu Ser Ser Leu Lys Ile Ser Pro Glu Glu Gln Ile
165 170 175
Gln Phe Leu Arg Lys Ile Ile Asn His Asn Leu Pro Val Arg Asn Ser
180 185 190
Ala Ile Glu Asn Thr Ile Asp Asn Met Tyr Leu Gln Asp Leu Glu Asn
195 200 205
Ser Thr Lys Leu Tyr Gly Lys Thr Gly Ala Gly Phe Thr Ala Asn Arg
210 215 220
Thr Leu Gln Asn Gly Trp Phe Glu Gly Phe Ile Ile Ser Lys Ser Gly
225 230 235 240
His Lys Tyr Val Phe Val Ser Ala Leu Thr Gly Ser Leu Gly Ser Asn
245 250 255
Leu Thr Ser Ser Ile Lys Ala Lys Lys Asn Ala Ile Thr Ile Leu Asn
260 265 270
Thr Leu Asn Leu
275
<210> 377
<211> 254
<212> PRT
<213> RESISTANCE GENE
<400> 377
Met Leu Leu Phe Met Phe Ser Ile Ile Ser Phe Gly Asn Glu Asn Gln
1 5 10 15
Phe Met Lys Glu Ile Phe Glu Arg Lys Gly Leu Asn Gly Thr Phe Val
20 25 30
Val Tyr Asp Leu Lys Asn Asp Lys Ile Asp Tyr Tyr Asn Leu Asp Arg
35 40 45
Ala Asn Glu Arg Phe Tyr Pro Ala Ser Ser Phe Lys Ile Phe Asn Thr
50 55 60
Leu Ile Gly Leu Glu Asn Gly Ile Val Lys Asn Val Asp Glu Met Phe
65 70 75 80
Tyr Tyr Tyr Asp Gly Ser Lys Val Phe Leu Asp Ser Trp Ala Lys Asp
85 90 95
Ser Asn Leu Arg Tyr Ala Ile Lys Val Ser Gln Val Pro Ala Tyr Lys
100 105 110
Lys Leu Ala Arg Glu Leu Gly Lys Glu Arg Met Gln Glu Gly Leu Asn
115 120 125
Lys Leu Asn Tyr Gly Asn Lys Glu Ile Gly Ser Glu Ile Asp Lys Phe
130 135 140
Trp Leu Glu Gly Pro Leu Lys Ile Ser Ala Met Glu Gln Val Lys Leu
145 150 155 160
Leu Asn Leu Leu Ser Gln Ser Lys Leu Pro Phe Lys Leu Glu Asn Gln
165 170 175
Glu Gln Val Lys Asp Ile Thr Ile Leu Glu Lys Lys Asp Asp Phe Ile
180 185 190
Leu His Gly Lys Thr Gly Trp Ala Thr Asp Asn Ile Val Val Pro Ile
195 200 205
Gly Trp Phe Val Gly Trp Ile Glu Thr Ser Asp Asn Ile Tyr Ser Phe
210 215 220
Ala Ile Asn Leu Asp Ile Ser Asp Ser Lys Phe Leu Pro Lys Arg Glu
225 230 235 240
Glu Ile Val Arg Glu Tyr Phe Lys Asn Ile Asn Val Ile Lys
245 250
<210> 378
<211> 265
<212> PRT
<213> RESISTANCE GENE
<400> 378
Met Arg Val Leu Ala Leu Ser Ala Val Phe Leu Val Ala Ser Ile Ile
1 5 10 15
Gly Met Pro Ala Val Ala Lys Glu Trp Gln Glu Asn Lys Ser Trp Asn
20 25 30
Ala His Phe Thr Glu His Lys Ser Gln Gly Val Val Val Leu Trp Asn
35 40 45
Glu Asn Lys Gln Gln Gly Phe Thr Asn Asn Leu Lys Arg Ala Asn Gln
50 55 60
Ala Phe Leu Pro Ala Ser Thr Phe Lys Ile Pro Asn Ser Leu Ile Ala
65 70 75 80
Leu Asp Leu Gly Val Val Lys Asp Glu His Gln Val Phe Lys Trp Asp
85 90 95
Gly Gln Thr Arg Asp Ile Ala Thr Trp Asn Arg Asp His Asn Leu Ile
100 105 110
Thr Ala Met Lys Tyr Ser Val Val Pro Val Tyr Gln Glu Phe Ala Arg
115 120 125
Gln Ile Gly Glu Ala Arg Met Ser Lys Met Leu His Ala Phe Asp Tyr
130 135 140
Gly Asn Glu Asp Ile Ser Gly Asn Val Asp Ser Phe Trp Leu Asp Gly
145 150 155 160
Gly Ile Arg Ile Ser Ala Thr Glu Gln Ile Ser Phe Leu Arg Lys Leu
165 170 175
Tyr His Asn Lys Leu His Val Ser Glu Arg Ser Gln Arg Ile Val Lys
180 185 190
Gln Ala Met Leu Thr Glu Ala Asn Gly Asp Tyr Ile Ile Arg Ala Lys
195 200 205
Thr Gly Tyr Ser Thr Arg Ile Glu Pro Lys Ile Gly Trp Trp Val Gly
210 215 220
Trp Val Glu Leu Asp Asp Asn Val Trp Phe Phe Ala Met Asn Met Asp
225 230 235 240
Met Pro Thr Ser Asp Gly Leu Gly Leu Arg Gln Ala Ile Thr Lys Glu
245 250 255
Val Leu Lys Gln Glu Lys Ile Ile Pro
260 265
<210> 379
<211> 271
<212> PRT
<213> RESISTANCE GENE
<400> 379
Met Leu Ser Arg Tyr Ser Lys Thr Leu Ala Phe Ala Val Val Ala Cys
1 5 10 15
Thr Leu Ala Ile Ser Thr Ala Thr Ala His Ala Glu Leu Val Val Arg
20 25 30
Asn Asp Leu Lys Arg Val Phe Asp Asp Ala Gly Val Ser Gly Thr Phe
35 40 45
Val Leu Met Asp Ile Thr Ala Asp Arg Thr Tyr Val Val Asp Pro Ala
50 55 60
Arg Ala Ala Arg Ser Ile His Pro Ala Ser Thr Phe Lys Ile Pro Asn
65 70 75 80
Ser Leu Ile Ala Phe Asp Thr Gly Ala Val Arg Asp Asp Gln Glu Val
85 90 95
Leu Pro Tyr Gly Gly Lys Pro Gln Pro Tyr Glu Gln Trp Glu His Asp
100 105 110
Met Ala Leu Pro Glu Ala Ile Arg Leu Ser Ala Val Pro Ile Tyr Gln
115 120 125
Glu Val Ala Arg Arg Val Gly Phe Glu Arg Met Gln Ala Tyr Val Asp
130 135 140
Ala Phe Asp Tyr Gly Asn Arg Gln Leu Gly Ser Ala Ile Asp Gln Phe
145 150 155 160
Trp Leu Arg Gly Pro Leu Glu Ile Ser Ala Phe Glu Glu Ala Arg Phe
165 170 175
Thr Ser Arg Met Ala Leu Lys Gln Leu Pro Val Lys Pro Arg Thr Trp
180 185 190
Asp Met Val Gln Arg Met Leu Leu Ile Glu Gln Gln Gly Asp Ala Ala
195 200 205
Leu Tyr Ala Lys Thr Gly Val Ala Thr Glu Tyr Gln Pro Glu Ile Gly
210 215 220
Trp Trp Ala Gly Trp Val Glu Arg Ala Gly His Val Tyr Ala Phe Ala
225 230 235 240
Leu Asn Ile Asp Met Pro Arg Glu Gly Asp Met Ala Lys Arg Ile Pro
245 250 255
Leu Gly Lys Gln Leu Met Arg Ala Leu Glu Val Trp Pro Ala Pro
260 265 270
<210> 380
<211> 262
<212> PRT
<213> RESISTANCE GENE
<400> 380
Met Arg Pro Leu Leu Phe Ser Ala Leu Leu Leu Leu Ser Gly His Thr
1 5 10 15
Gln Ala Ser Glu Trp Asn Asp Ser Gln Ala Val Asp Lys Leu Phe Gly
20 25 30
Ala Ala Gly Val Lys Gly Thr Phe Val Leu Tyr Asp Val Gln Arg Gln
35 40 45
Arg Tyr Val Gly His Asp Arg Glu Arg Ala Glu Thr Arg Phe Val Pro
50 55 60
Ala Ser Thr Tyr Lys Val Ala Asn Ser Leu Ile Gly Leu Ser Thr Gly
65 70 75 80
Ala Val Arg Ser Ala Asp Glu Val Leu Pro Tyr Gly Gly Lys Pro Gln
85 90 95
Arg Phe Lys Ala Trp Glu His Asp Met Ser Leu Arg Asp Ala Ile Lys
100 105 110
Ala Ser Asn Val Pro Val Tyr Gln Glu Leu Ala Arg Arg Ile Gly Leu
115 120 125
Glu Arg Met Arg Ala Asn Val Ser Arg Leu Gly Tyr Gly Asn Ala Glu
130 135 140
Ile Gly Gln Val Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile
145 150 155 160
Ser Ala Met Glu Gln Thr Arg Phe Leu Leu Arg Leu Ala Gln Gly Glu
165 170 175
Leu Pro Phe Pro Ala Pro Val Gln Ser Thr Val Arg Ala Met Thr Leu
180 185 190
Leu Glu Ser Gly Pro Gly Trp Glu Leu His Gly Lys Thr Gly Trp Cys
195 200 205
Phe Asp Cys Thr Pro Glu Leu Gly Trp Trp Val Gly Trp Val Lys Arg
210 215 220
Asn Glu Arg Leu Tyr Gly Phe Ala Leu Asn Ile Asp Met Pro Gly Gly
225 230 235 240
Glu Ala Asp Ile Gly Lys Arg Val Glu Leu Gly Lys Ala Ser Leu Lys
245 250 255
Ala Leu Gly Ile Leu Pro
260
<210> 381
<211> 289
<212> PRT
<213> RESISTANCE GENE
<400> 381
Met Asn Lys Gly Leu His Arg Lys Arg Leu Ser Lys Arg Leu Leu Leu
1 5 10 15
Pro Met Leu Leu Cys Leu Leu Ala Gln Gln Thr Gln Ala Val Ala Ala
20 25 30
Glu Gln Thr Lys Val Ser Asp Val Cys Ser Glu Val Thr Ala Glu Gly
35 40 45
Trp Gln Glu Val Arg Arg Trp Asp Lys Leu Phe Glu Ser Ala Gly Val
50 55 60
Lys Gly Ser Leu Leu Leu Trp Asp Gln Lys Arg Ser Leu Gly Leu Ser
65 70 75 80
Asn Asn Leu Ser Arg Ala Ala Glu Gly Phe Ile Pro Ala Ser Thr Phe
85 90 95
Lys Leu Pro Ser Ser Leu Ile Ala Leu Glu Thr Gly Ala Val Arg Asp
100 105 110
Glu Thr Ser Arg Phe Ser Trp Asp Gly Lys Val Arg Glu Ile Ala Val
115 120 125
Trp Asn Arg Asp Gln Ser Phe Arg Thr Ala Met Lys Tyr Ser Val Val
130 135 140
Pro Val Tyr Gln Gln Leu Ala Arg Glu Ile Gly Pro Lys Val Met Ala
145 150 155 160
Ala Met Val Arg Gln Leu Glu Tyr Gly Asn Gln Asp Ile Gly Gly Gln
165 170 175
Ala Asp Ser Phe Trp Leu Asp Gly Gln Leu Arg Ile Thr Ala Phe Gln
180 185 190
Gln Val Asp Phe Leu Arg Gln Leu His Asp Asn Lys Leu Pro Val Ser
195 200 205
Glu Arg Ser Gln Arg Ile Val Lys Gln Met Met Leu Thr Glu Ala Ser
210 215 220
Thr Asp Tyr Ile Ile Arg Ala Lys Thr Gly Tyr Gly Val Arg Arg Thr
225 230 235 240
Pro Ala Ile Gly Trp Trp Val Gly Trp Leu Glu Leu Asp Asp Asn Thr
245 250 255
Val Tyr Phe Ala Val Asn Leu Asp Leu Ala Ser Ala Ser Gln Leu Pro
260 265 270
Leu Arg Gln Gln Leu Val Lys Gln Val Leu Lys Gln Glu Gln Leu Leu
275 280 285
Pro
<210> 382
<211> 285
<212> PRT
<213> RESISTANCE GENE
<400> 382
Met Asn Thr Ile Ile Ser Arg Arg Trp Arg Ala Gly Leu Trp Arg Arg
1 5 10 15
Leu Val Gly Ala Val Val Leu Pro Ala Thr Leu Ala Ala Thr Pro Ala
20 25 30
Ala Tyr Ala Ala Asp Val Pro Lys Ala Ala Leu Gly Arg Ile Thr Glu
35 40 45
Arg Ala Asp Trp Gly Lys Leu Phe Ala Ala Glu Gly Val Lys Gly Thr
50 55 60
Ile Val Val Leu Asp Ala Arg Thr Gln Thr Tyr Gln Ala Tyr Asp Ala
65 70 75 80
Ala Arg Ala Glu Lys Arg Met Ser Pro Ala Ser Thr Tyr Lys Ile Phe
85 90 95
Asn Ser Leu Leu Ala Leu Asp Ser Gly Ala Leu Asp Asn Glu Arg Ala
100 105 110
Ile Ile Pro Trp Asp Gly Lys Pro Arg Arg Ile Lys Asn Trp Asn Ala
115 120 125
Ala Met Asp Leu Arg Thr Ala Phe Arg Val Ser Cys Leu Pro Cys Tyr
130 135 140
Gln Val Val Ser His Lys Ile Gly Arg Arg Tyr Ala Gln Ala Lys Leu
145 150 155 160
Asn Glu Val Gly Tyr Gly Asn Arg Thr Ile Gly Gly Ala Pro Asp Ala
165 170 175
Tyr Trp Val Asp Asp Ser Leu Gln Ile Ser Ala Arg Glu Gln Val Asp
180 185 190
Phe Val Gln Arg Leu Ala Arg Gly Thr Leu Pro Phe Ser Ala Arg Ser
195 200 205
Gln Asp Ile Val Arg Gln Met Ser Ile Val Glu Ala Thr Pro Asp Tyr
210 215 220
Val Leu His Gly Lys Thr Gly Trp Phe Val Asp Lys Lys Pro Asp Ile
225 230 235 240
Gly Trp Trp Val Gly Trp Ile Glu Arg Asp Gly Asn Ile Thr Ser Val
245 250 255
Ala Ile Asn Ile Asp Met Leu Ser Glu Ala Asp Ala Pro Lys Arg Ala
260 265 270
Arg Ile Val Lys Ala Val Leu Lys Asp Leu Lys Leu Ile
275 280 285
<210> 383
<211> 266
<212> PRT
<213> RESISTANCE GENE
<400> 383
Met Lys Thr Phe Ala Ala Tyr Val Ile Thr Ala Cys Leu Ser Ser Thr
1 5 10 15
Ala Leu Ala Ser Ser Ile Thr Glu Asn Thr Phe Trp Asn Lys Glu Phe
20 25 30
Ser Ala Glu Ala Val Asn Gly Val Phe Val Leu Cys Lys Ser Ser Ser
35 40 45
Lys Ser Cys Ala Thr Asn Asn Leu Ala Arg Ala Ser Lys Glu Tyr Leu
50 55 60
Pro Ala Ser Thr Phe Lys Ile Pro Asn Ala Ile Ile Gly Leu Glu Thr
65 70 75 80
Gly Val Ile Lys Asn Glu His Gln Ile Phe Lys Trp Asp Gly Lys Pro
85 90 95
Arg Ala Met Lys Gln Trp Glu Arg Asp Leu Ser Leu Arg Gly Ala Ile
100 105 110
Gln Val Ser Ala Val Pro Val Phe Gln Gln Ile Ala Arg Glu Val Gly
115 120 125
Glu Val Arg Met Gln Lys Tyr Leu Lys Lys Phe Ser Tyr Gly Asn Gln
130 135 140
Asn Ile Ser Gly Gly Ile Asp Lys Phe Trp Leu Glu Gly Gln Leu Arg
145 150 155 160
Ile Ser Ala Val Asn Gln Val Glu Phe Leu Glu Ser Leu Phe Leu Asn
165 170 175
Lys Leu Ser Ala Ser Lys Glu Asn Gln Leu Ile Val Lys Glu Ala Leu
180 185 190
Val Thr Glu Ala Ala Pro Glu Tyr Leu Val His Ser Lys Thr Gly Phe
195 200 205
Ser Gly Val Gly Thr Glu Ser Asn Pro Gly Val Ala Trp Trp Val Gly
210 215 220
Trp Val Glu Lys Gly Ala Glu Val Tyr Phe Phe Ala Phe Asn Met Asp
225 230 235 240
Ile Asp Asn Glu Asn Lys Leu Pro Leu Arg Lys Ser Ile Pro Thr Lys
245 250 255
Ile Met Ala Ser Glu Gly Ile Ile Gly Gly
260 265
<210> 384
<211> 265
<212> PRT
<213> RESISTANCE GENE
<400> 384
Met Arg Val Leu Ala Leu Ser Ala Val Leu Val Val Ala Ser Ile Val
1 5 10 15
Gly Met Pro Ala Met Ala Asn Glu Trp Gln Glu Lys Pro Ser Trp Asn
20 25 30
Thr His Phe Ser Glu His Lys Ala Gln Gly Val Ile Val Leu Trp Asn
35 40 45
Glu Asn Lys Gln Gln Gly Phe Thr Asn Asn Leu Lys Arg Ala Asn Gln
50 55 60
Ala Phe Leu Pro Ala Ser Thr Phe Lys Ile Pro Asn Ser Leu Ile Ala
65 70 75 80
Leu Asp Leu Gly Val Val Lys Asp Glu His Gln Val Phe Lys Trp Asp
85 90 95
Gly Gln Thr Arg Asp Ile Ala Ala Trp Asn Arg Asp His Asp Leu Ile
100 105 110
Thr Ala Met Lys Tyr Ser Val Val Pro Val Tyr Gln Glu Phe Ala Arg
115 120 125
Gln Ile Gly Gln Ala Arg Met Ser Lys Met Leu His Ala Phe Asp Tyr
130 135 140
Gly Asn Glu Asp Ile Ser Gly Asn Leu Asp Ser Phe Trp Leu Asp Gly
145 150 155 160
Gly Ile Arg Ile Ser Ala Thr Glu Gln Val Ala Phe Leu Arg Lys Leu
165 170 175
Tyr His Asn Lys Leu His Val Ser Glu Arg Ser Gln Arg Ile Val Lys
180 185 190
Gln Ala Met Leu Thr Glu Ala Asn Ser Asp Tyr Ile Ile Arg Ala Lys
195 200 205
Thr Gly Tyr Ser Thr Arg Ile Glu Pro Gln Ile Gly Trp Trp Val Gly
210 215 220
Trp Val Glu Leu Asp Asp Asn Val Trp Phe Phe Ala Met Asn Met Asp
225 230 235 240
Met Pro Thr Ala Asp Gly Leu Gly Leu Arg Gln Ala Ile Thr Lys Glu
245 250 255
Val Leu Lys Gln Glu Lys Ile Ile Pro
260 265
<210> 385
<211> 257
<212> PRT
<213> RESISTANCE GENE
<400> 385
Met Lys Lys Ile Thr Leu Phe Leu Leu Phe Leu Asn Leu Val Phe Gly
1 5 10 15
Gln Asp Lys Ile Leu Asn Asn Trp Phe Lys Glu Tyr Asn Thr Ser Gly
20 25 30
Thr Phe Val Phe Tyr Asp Gly Lys Thr Trp Ala Ser Asn Asp Phe Ser
35 40 45
Arg Ala Met Glu Thr Phe Ser Pro Ala Ser Thr Phe Lys Ile Phe Asn
50 55 60
Ala Leu Ile Ala Leu Asp Ser Gly Val Ile Lys Thr Lys Lys Glu Ile
65 70 75 80
Phe Tyr His Tyr Arg Gly Glu Lys Val Phe Leu Ser Ser Trp Ala Gln
85 90 95
Asp Met Asn Leu Ser Ser Ala Ile Lys Tyr Ser Asn Val Leu Ala Phe
100 105 110
Lys Glu Val Ala Arg Arg Ile Gly Ile Lys Thr Met Gln Glu Tyr Leu
115 120 125
Asn Lys Leu His Tyr Gly Asn Ala Lys Ile Ser Lys Ile Asp Thr Phe
130 135 140
Trp Leu Asp Asn Ser Leu Lys Ile Ser Ala Lys Glu Gln Ala Ile Leu
145 150 155 160
Leu Phe Arg Leu Ser Gln Asn Ser Leu Pro Phe Ser Gln Glu Ala Met
165 170 175
Asn Ser Val Lys Glu Met Ile Tyr Leu Lys Asn Met Glu Asn Leu Glu
180 185 190
Leu Phe Gly Lys Thr Gly Phe Asn Asp Gly Gln Lys Ile Ala Trp Ile
195 200 205
Val Gly Phe Val Tyr Leu Lys Asp Glu Asn Lys Tyr Lys Ala Phe Ala
210 215 220
Leu Asn Leu Asp Ile Asp Lys Phe Glu Asp Leu Tyr Lys Arg Glu Lys
225 230 235 240
Ile Leu Glu Lys Tyr Leu Asp Glu Leu Val Lys Lys Val Lys Asn Asp
245 250 255
Gly
<210> 386
<211> 268
<212> PRT
<213> RESISTANCE GENE
<400> 386
Met Ser Lys Lys Asn Phe Ile Leu Ile Phe Ile Phe Val Ile Leu Ile
1 5 10 15
Ser Cys Lys Asn Thr Glu Lys Ile Ser Asn Glu Thr Thr Leu Ile Asp
20 25 30
Asn Ile Phe Thr Asn Ser Asn Ala Glu Gly Thr Leu Val Ile Tyr Asn
35 40 45
Leu Asn Asp Asp Lys Tyr Ile Ile His Asn Lys Glu Arg Ala Glu Gln
50 55 60
Arg Phe Tyr Pro Ala Ser Thr Phe Lys Ile Tyr Asn Ser Leu Ile Gly
65 70 75 80
Leu Asn Glu Lys Ala Val Lys Asp Val Asp Glu Val Phe Tyr Lys Leu
85 90 95
Met Ala Lys Ser Phe Leu Glu Ser Trp Ala Lys Asp Ser Asn Leu Arg
100 105 110
Tyr Ala Ile Lys Asn Ser Gln Val Pro Ala Tyr Lys Glu Leu Ala Arg
115 120 125
Arg Ile Gly Ile Lys Lys Met Lys Glu Asn Ile Glu Lys Leu Asp Phe
130 135 140
Gly Asn Lys Ser Ile Gly Asp Ser Val Asp Thr Phe Trp Leu Glu Gly
145 150 155 160
Pro Leu Glu Ile Ser Ala Met Glu Gln Val Lys Leu Leu Thr Lys Leu
165 170 175
Ala Gln Asn Glu Leu Gln Tyr Pro Ile Glu Ile Gln Lys Ala Ile Ser
180 185 190
Asp Ile Thr Ile Thr Arg Ala Asn Leu His Ile Thr Leu His Gly Lys
195 200 205
Thr Gly Leu Ala Asp Ser Lys Asn Met Thr Thr Glu Pro Ile Gly Trp
210 215 220
Phe Val Gly Trp Leu Glu Glu Asn Asp Asn Ile Tyr Val Phe Ala Leu
225 230 235 240
Asn Ile Asp Asn Ile Asn Ser Asp Asp Leu Ala Lys Arg Ile Asn Ile
245 250 255
Val Lys Glu Ser Leu Lys Ala Leu Asn Leu Leu Lys
260 265
<210> 387
<211> 273
<212> PRT
<213> RESISTANCE GENE
<400> 387
Met Asn Lys Tyr Phe Thr Cys Tyr Val Val Ala Ser Leu Phe Leu Ser
1 5 10 15
Gly Cys Thr Val Gln His Asn Leu Ile Asn Glu Thr Pro Ser Gln Ile
20 25 30
Val Gln Gly His Asn Gln Val Ile His Gln Tyr Phe Asp Glu Lys Asn
35 40 45
Thr Ser Gly Val Leu Val Ile Gln Thr Asp Lys Lys Ile Asn Leu Tyr
50 55 60
Gly Asn Ala Leu Ser Arg Ala Asn Thr Glu Tyr Val Pro Ala Ser Thr
65 70 75 80
Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu Asn Gln Lys Thr Asp
85 90 95
Ile Asn Glu Ile Phe Lys Trp Lys Gly Glu Lys Arg Ser Phe Thr Ala
100 105 110
Trp Glu Lys Asp Met Thr Leu Gly Glu Ala Met Lys Leu Ser Ala Val
115 120 125
Pro Val Tyr Gln Glu Leu Ala Arg Arg Ile Gly Leu Asp Leu Met Gln
130 135 140
Lys Glu Val Lys Arg Ile Gly Phe Gly Asn Ala Glu Ile Gly Gln Gln
145 150 155 160
Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Val Thr Pro Ile Gln
165 170 175
Glu Val Glu Phe Val Ser Gln Leu Ala His Thr Gln Leu Pro Phe Ser
180 185 190
Glu Lys Val Gln Ala Asn Val Lys Asn Met Leu Leu Leu Glu Glu Ser
195 200 205
Asn Gly Tyr Lys Ile Phe Gly Lys Thr Gly Trp Ala Met Asp Ile Lys
210 215 220
Pro Gln Val Gly Trp Leu Thr Gly Trp Val Glu Gln Pro Asp Gly Lys
225 230 235 240
Ile Val Ala Phe Ala Leu Lys Met Glu Met Arg Ser Glu Met Pro Ala
245 250 255
Ser Ile Arg Asn Glu Leu Leu Met Lys Ser Leu Lys Gln Leu Asn Ile
260 265 270
Ile
<210> 388
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 388
Met Asn Ile Gln Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn Tyr Ser Ala Ser
20 25 30
Lys Ser Asp Glu Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Gln Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asn Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Asn Glu Val Lys Arg Ile Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asn Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Ser
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Arg Gly Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 389
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 389
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Glu Lys Gly Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Gln Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Pro Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asp Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 390
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 390
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Glu Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Lys Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asn Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 391
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 391
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Val Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Lys Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asn Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 392
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 392
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Ser Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Glu Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Gln Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asn Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Asn Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Glu Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asn Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 393
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 393
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Asp Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile His Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Glu Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asn Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asn Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 394
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 394
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Lys Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asn Gly Gln Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Asn Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln His Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asp Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 395
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 395
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Glu Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Thr
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Gln Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Pro Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asp Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 396
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 396
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Ser Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Glu Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Ala Val Phe Lys Trp Asp Gly Gln Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asn Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Asn Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asn Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Thr Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 397
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 397
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Ser Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Glu Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Gln Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asn Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Pro Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Asn Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asn Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 398
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 398
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Val Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Lys Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asn Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Lys Leu Gly
260 265 270
Ile Leu
<210> 399
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 399
Met Asn Ile Lys Thr Leu Leu Leu Ile Thr Ser Thr Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Thr Ser
20 25 30
Lys Ser Asp Glu Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Ile Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Ile Phe Lys Trp Asp Gly Gln Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Leu Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asp Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 400
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 400
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Val Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Lys Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Ser Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Ala Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asn Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 401
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 401
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Val Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Lys Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Leu Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asn Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 402
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 402
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Asp Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile His Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Glu Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asn Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asn Pro Gln Val Gly Trp Leu Thr Gly Ser Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 403
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 403
Met Asn Ile Lys Thr Leu Leu Leu Ile Thr Ser Thr Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Thr Ser
20 25 30
Lys Ser Asp Glu Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Ile Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Ile Phe Lys Trp Asp Gly Gln Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Leu Lys Ala Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asp Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 404
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 404
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Lys Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Lys Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asn Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 405
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 405
Met Asn Ile Lys Thr Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser His Tyr Ile Val Ser Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Glu Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Gln Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asn Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Asn Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Thr Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asn Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 406
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 406
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Ser Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Glu Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Gln Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asn Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Asn Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asp Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 407
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 407
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Thr Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Glu Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Ser Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Gln Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Asn Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asn Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 408
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 408
Met Asn Ile Gln Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Ser Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Glu Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Lys Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asn Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro His Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 409
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 409
Met Asn Ile Lys Ala Leu Phe Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Glu Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Lys Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asp Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 410
<211> 280
<212> PRT
<213> RESISTANCE GENE
<400> 410
Met Lys Leu Leu Lys Ile Leu Ser Leu Val Cys Leu Ser Ile Ser Ile
1 5 10 15
Gly Ala Cys Ala Glu His Ser Met Ser Arg Ala Lys Thr Ser Thr Ile
20 25 30
Pro Gln Val Asn Asn Ser Ile Ile Asp Gln Asn Val Gln Ala Leu Phe
35 40 45
Asn Glu Ile Ser Ala Asp Ala Val Phe Val Thr Tyr Asp Gly Gln Asn
50 55 60
Ile Lys Lys Tyr Gly Thr His Leu Asp Arg Ala Lys Thr Ala Tyr Ile
65 70 75 80
Pro Ala Ser Thr Phe Lys Ile Ala Asn Ala Leu Ile Gly Leu Glu Asn
85 90 95
His Lys Ala Thr Ser Thr Glu Ile Phe Lys Trp Asp Gly Lys Pro Arg
100 105 110
Phe Phe Lys Ala Trp Asp Lys Asp Phe Thr Leu Gly Glu Ala Met Gln
115 120 125
Ala Ser Thr Val Pro Val Tyr Gln Glu Leu Ala Arg Arg Ile Gly Pro
130 135 140
Ser Leu Met Gln Ser Glu Leu Gln Arg Ile Gly Tyr Gly Asn Met Gln
145 150 155 160
Met Gly Thr Glu Val Asp Gln Phe Trp Leu Lys Gly Pro Leu Thr Ile
165 170 175
Thr Pro Ile Gln Glu Val Lys Phe Val Tyr Asp Leu Ala Gln Gly Gln
180 185 190
Leu Pro Phe Lys Pro Glu Val Gln Gln Gln Val Lys Glu Met Leu Tyr
195 200 205
Val Glu Arg Arg Gly Glu Asn Arg Leu Tyr Ala Lys Ser Gly Trp Gly
210 215 220
Met Ala Val Asp Pro Gln Val Gly Trp Tyr Val Gly Phe Val Glu Lys
225 230 235 240
Ala Asp Gly Gln Val Val Ala Phe Ala Leu Asn Met Gln Met Lys Ala
245 250 255
Gly Asp Asp Ile Ala Leu Arg Lys Gln Leu Ser Leu Asp Val Leu Asp
260 265 270
Lys Leu Gly Val Phe His Tyr Leu
275 280
<210> 411
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 411
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Thr Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Thr Ser
20 25 30
Lys Ser Asp Glu Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Ile Phe Lys Trp Asp Gly Gln Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Leu Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asp Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 412
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 412
Met Asn Ile Lys Thr Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Glu Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Val
35 40 45
His Thr Thr Gly Val Leu Val Ile Arg Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Gln Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Pro Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Met Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asp Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 413
<211> 280
<212> PRT
<213> RESISTANCE GENE
<400> 413
Met Lys Leu Leu Lys Ile Leu Ser Leu Val Cys Leu Ser Ile Ser Ile
1 5 10 15
Gly Ala Cys Ala Glu His Ser Met Ser Arg Ala Lys Thr Ser Thr Ile
20 25 30
Pro Gln Val Asn Asn Ser Ile Ile Asp Gln Asn Val Gln Ala Leu Phe
35 40 45
Asn Glu Ile Ser Gly Asp Ala Val Phe Val Thr Tyr Asp Gly Gln Asn
50 55 60
Ile Lys Lys Tyr Gly Thr His Leu Asp Arg Ala Lys Thr Ala Tyr Ile
65 70 75 80
Pro Ala Ser Thr Phe Lys Ile Ala Asn Ala Leu Ile Gly Leu Glu Asn
85 90 95
His Lys Ala Thr Ser Thr Glu Ile Phe Lys Trp Asp Gly Lys Pro Arg
100 105 110
Phe Phe Lys Ala Trp Asp Lys Asp Phe Thr Leu Gly Glu Ala Met Gln
115 120 125
Ala Ser Thr Val Pro Val Tyr Gln Glu Leu Ala Arg Arg Ile Gly Pro
130 135 140
Ser Leu Met Gln Ser Glu Leu Gln Arg Ile Gly Tyr Gly Asn Met Gln
145 150 155 160
Ile Gly Thr Glu Val Asp Gln Phe Trp Leu Lys Gly Pro Leu Thr Ile
165 170 175
Thr Pro Ile Gln Glu Val Lys Phe Val Tyr Asp Leu Ala Gln Gly Gln
180 185 190
Leu Pro Phe Lys Pro Glu Val Gln Gln Gln Val Lys Glu Met Leu Tyr
195 200 205
Val Glu Arg Arg Gly Glu Asn Arg Leu Tyr Ala Lys Ser Gly Trp Gly
210 215 220
Met Ala Val Asp Pro Gln Val Gly Trp Tyr Val Gly Phe Val Glu Lys
225 230 235 240
Ala Asp Gly Gln Val Val Ala Phe Ala Leu Asn Met Gln Met Lys Ala
245 250 255
Gly Asp Asp Ile Ala Leu Arg Lys Gln Leu Ser Leu Asp Val Leu Asp
260 265 270
Lys Leu Gly Val Phe His Tyr Leu
275 280
<210> 414
<211> 275
<212> PRT
<213> RESISTANCE GENE
<400> 414
Met Lys Lys Phe Ile Leu Pro Ile Phe Ser Ile Ser Ile Leu Val Ser
1 5 10 15
Leu Ser Ala Cys Ser Ser Ile Lys Thr Lys Ser Glu Asp Asn Phe His
20 25 30
Ile Ser Ser Gln Gln His Glu Lys Ala Ile Lys Ser Tyr Phe Asp Glu
35 40 45
Ala Gln Thr Gln Gly Val Ile Ile Ile Lys Glu Gly Lys Asn Leu Ser
50 55 60
Thr Tyr Gly Asn Ala Leu Ala Arg Ala Asn Lys Glu Tyr Val Pro Ala
65 70 75 80
Ser Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu Asn His Lys
85 90 95
Ala Thr Thr Asn Glu Ile Phe Lys Trp Asp Gly Lys Lys Arg Thr Tyr
100 105 110
Pro Met Trp Glu Lys Asp Met Thr Leu Gly Glu Ala Met Ala Leu Ser
115 120 125
Ala Val Pro Val Tyr Gln Glu Leu Ala Arg Arg Thr Gly Leu Glu Leu
130 135 140
Met Gln Lys Glu Val Lys Arg Val Asn Phe Gly Asn Thr Asn Ile Gly
145 150 155 160
Thr Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro
165 170 175
Val Gln Glu Val Asn Phe Ala Asp Asp Leu Ala His Asn Arg Leu Pro
180 185 190
Phe Lys Leu Glu Thr Gln Glu Glu Val Lys Lys Met Leu Leu Ile Lys
195 200 205
Glu Val Asn Gly Ser Lys Ile Tyr Ala Lys Ser Gly Trp Gly Met Asp
210 215 220
Val Thr Pro Gln Val Gly Trp Leu Thr Gly Trp Val Glu Gln Ala Asn
225 230 235 240
Gly Lys Lys Ile Pro Phe Ser Leu Asn Leu Glu Met Lys Glu Gly Met
245 250 255
Ser Gly Ser Ile Arg Asn Glu Ile Thr Tyr Lys Ser Leu Glu Asn Leu
260 265 270
Gly Ile Ile
275
<210> 415
<211> 275
<212> PRT
<213> RESISTANCE GENE
<400> 415
Met Ala Ile Arg Ile Phe Ala Ile Leu Phe Ser Ile Phe Ser Leu Ala
1 5 10 15
Thr Phe Ala His Ala Gln Glu Gly Thr Leu Glu Arg Ser Asp Trp Arg
20 25 30
Lys Phe Phe Ser Glu Phe Gln Ala Lys Gly Thr Ile Val Val Ala Asp
35 40 45
Glu Arg Gln Ala Asp Arg Ala Met Leu Val Phe Asp Pro Val Arg Ser
50 55 60
Lys Lys Arg Tyr Ser Pro Ala Ser Thr Phe Lys Ile Pro His Thr Leu
65 70 75 80
Phe Ala Leu Asp Ala Gly Ala Val Arg Asp Glu Phe Gln Ile Phe Arg
85 90 95
Trp Asp Gly Val Asn Arg Gly Phe Ala Gly His Asn Gln Asp Gln Asp
100 105 110
Leu Arg Ser Ala Met Arg Asn Ser Thr Val Trp Val Tyr Glu Leu Phe
115 120 125
Ala Lys Glu Ile Gly Asp Asp Lys Ala Arg Arg Tyr Leu Lys Lys Ile
130 135 140
Asp Tyr Gly Asn Ala Asp Pro Ser Thr Ser Asn Gly Asp Tyr Trp Ile
145 150 155 160
Glu Ser Ser Leu Ala Ile Ser Ala Gln Glu Gln Ile Ala Phe Leu Arg
165 170 175
Lys Leu Tyr Arg Asn Glu Leu Pro Phe Arg Val Glu His Gln Arg Leu
180 185 190
Val Lys Asp Leu Met Ile Val Glu Ala Gly Arg Asn Trp Ile Leu Arg
195 200 205
Ala Lys Thr Gly Trp Glu Gly Arg Met Gly Trp Trp Val Gly Trp Val
210 215 220
Glu Trp Pro Thr Gly Ser Val Phe Phe Ala Leu Asn Ile Asp Thr Pro
225 230 235 240
Asn Arg Met Asp Asp Leu Phe Lys Arg Glu Ala Ile Val Arg Ala Ile
245 250 255
Leu Arg Ser Ile Glu Ala Leu Pro Pro Asn Pro Ala Val Asn Ser Asp
260 265 270
Ala Ala Arg
275
<210> 416
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 416
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Glu Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Lys Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asn Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Asn Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asp Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 417
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 417
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Val Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Lys Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Leu Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Val Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asn Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 418
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 418
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Lys Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asn Gly Gln Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Asn Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asp Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 419
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 419
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Asp Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile His Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Glu Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asn Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Val Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asn Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 420
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 420
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Thr Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Glu Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Lys Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Thr Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Val Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asp Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 421
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 421
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Val Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Lys Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Gln Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asn Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 422
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 422
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Asp Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile His Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Glu Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asn Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Leu Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asn Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 423
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 423
Met Asn Ile Lys Thr Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Ser Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Glu Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Gln Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Pro Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Met Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asp Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 424
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 424
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Asp Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile His Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Glu Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asn Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asn Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Pro Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 425
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 425
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Val Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Lys Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Gly Asp Val
210 215 220
Asn Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 426
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 426
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Val Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Lys Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Leu Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asn Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 427
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 427
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Val Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Lys Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Val Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asn Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 428
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 428
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Glu Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Thr
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Gln Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Val Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Pro Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asp Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 429
<211> 269
<212> PRT
<213> RESISTANCE GENE
<400> 429
Met Ser Lys Lys Asn Phe Ile Leu Ile Phe Ile Phe Val Ile Leu Ile
1 5 10 15
Ser Cys Lys Asn Thr Glu Lys Ile Ser Asn Glu Thr Thr Leu Ile Asp
20 25 30
Asn Ile Phe Thr Asn Ser Asn Ala Glu Gly Thr Leu Val Ile Tyr Asn
35 40 45
Leu Asn Asp Asp Lys Tyr Ile Ile His Asn Lys Glu Arg Ala Glu Gln
50 55 60
Arg Phe Tyr Pro Ala Ser Thr Phe Lys Ile Tyr Asn Ser Leu Ile Gly
65 70 75 80
Leu Asn Glu Lys Ala Val Lys Asp Val Asp Glu Val Phe Tyr Lys Tyr
85 90 95
Asn Gly Glu Lys Val Phe Leu Glu Ser Trp Ala Lys Asp Ser Asn Leu
100 105 110
Arg Tyr Ala Ile Lys Asn Ser Gln Val Pro Ala Tyr Lys Glu Leu Ala
115 120 125
Arg Arg Ile Gly Leu Lys Lys Met Lys Glu Asn Ile Glu Lys Leu Asp
130 135 140
Phe Gly Asn Lys Ser Ile Gly Asp Ser Val Asp Thr Phe Trp Leu Glu
145 150 155 160
Gly Pro Leu Glu Ile Ser Ala Met Glu Gln Val Lys Leu Leu Thr Lys
165 170 175
Leu Ala Gln Asn Glu Leu Pro Tyr Pro Ile Glu Ile Gln Lys Ala Val
180 185 190
Ser Asp Ile Thr Ile Leu Glu Gln Thr Tyr Asn Tyr Thr Leu His Gly
195 200 205
Lys Thr Gly Leu Ala Asp Ser Lys Asn Met Thr Thr Glu Pro Ile Gly
210 215 220
Trp Phe Val Gly Trp Leu Glu Glu Asn Asp Asn Ile Tyr Val Phe Ala
225 230 235 240
Leu Asn Ile Asp Asn Ile Asn Ser Asp Asp Leu Ala Lys Arg Ile Asn
245 250 255
Ile Val Lys Glu Ser Leu Lys Ala Leu Asn Leu Leu Lys
260 265
<210> 430
<211> 269
<212> PRT
<213> RESISTANCE GENE
<400> 430
Met Ser Lys Lys Asn Phe Ile Leu Ile Phe Ile Phe Val Ile Leu Thr
1 5 10 15
Ser Cys Lys Asn Thr Glu Lys Ile Ser Asn Glu Thr Thr Leu Ile Asp
20 25 30
Asn Ile Phe Thr Asn Ser Asn Ala Glu Gly Thr Leu Val Ile Tyr Asn
35 40 45
Leu Asn Asp Asp Lys Tyr Ile Ile His Asn Lys Glu Arg Ala Glu Gln
50 55 60
Arg Phe Tyr Pro Ala Ser Thr Phe Lys Ile Tyr Asn Ser Leu Ile Gly
65 70 75 80
Leu Asn Glu Lys Ala Val Lys Asp Val Asp Glu Val Phe Tyr Lys Tyr
85 90 95
Asn Gly Glu Lys Val Phe Leu Glu Ser Trp Ala Lys Asp Ser Asn Leu
100 105 110
Arg Tyr Ala Ile Lys Asn Ser Gln Val Pro Ala Tyr Lys Glu Leu Ala
115 120 125
Arg Arg Ile Gly Leu Lys Lys Met Lys Glu Asn Ile Glu Lys Leu Asp
130 135 140
Phe Gly Asn Lys Ser Ile Gly Asp Ser Val Asp Thr Phe Trp Leu Glu
145 150 155 160
Gly Pro Leu Glu Ile Ser Ala Met Glu Gln Ile Lys Leu Leu Thr Lys
165 170 175
Leu Ala Gln Asn Glu Leu Pro Tyr Pro Ile Glu Ile Gln Lys Ala Val
180 185 190
Ser Asp Ile Thr Ile Leu Glu Gln Thr Tyr Asn Tyr Thr Leu His Gly
195 200 205
Lys Thr Gly Leu Ala Asp Ser Lys Asn Met Thr Thr Glu Pro Ile Gly
210 215 220
Trp Phe Val Gly Trp Leu Glu Glu Asn Asp Asn Ile Tyr Val Phe Ala
225 230 235 240
Leu Asn Ile Asp Asn Ile Asn Ser Asp Asp Leu Ala Lys Arg Ile Asn
245 250 255
Ile Val Lys Glu Ser Leu Lys Ala Leu Asn Leu Leu Lys
260 265
<210> 431
<211> 262
<212> PRT
<213> RESISTANCE GENE
<400> 431
Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser Ala Cys Ser Pro Tyr Ile
1 5 10 15
Val Ser Ala Asn Pro Asn His Ser Ala Ser Lys Ser Asp Asp Lys Ala
20 25 30
Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala His Thr Thr Gly Val Leu
35 40 45
Val Ile Gln Gln Gly Gln Thr Gln Gln Ser Tyr Gly Asn Asp Leu Ala
50 55 60
Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser Thr Phe Lys Met Leu Asn
65 70 75 80
Ala Leu Ile Gly Leu Glu His His Lys Ala Thr Thr Thr Glu Val Phe
85 90 95
Lys Trp Asp Gly Gln Lys Arg Leu Phe Pro Glu Trp Glu Lys Asn Met
100 105 110
Thr Leu Gly Asp Ala Met Lys Ala Ser Ala Ile Pro Val Tyr Gln Asp
115 120 125
Leu Ala Arg Arg Ile Gly Leu Glu Leu Met Ser Asn Glu Val Lys Arg
130 135 140
Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr Gln Val Asp Asn Phe Trp
145 150 155 160
Leu Val Gly Pro Leu Lys Ile Thr Pro Gln Gln Glu Ala Gln Phe Ala
165 170 175
Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe Ser Gln Lys Val Gln Asp
180 185 190
Glu Val Gln Ser Met Leu Phe Ile Glu Glu Lys Asn Gly Asn Lys Ile
195 200 205
Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val Asp Pro Gln Val Gly Trp
210 215 220
Leu Thr Gly Trp Val Val Gln Pro Gln Gly Asn Ile Val Ala Phe Ser
225 230 235 240
Leu Asn Leu Glu Met Lys Lys Gly Ile Pro Ser Ser Val Arg Lys Glu
245 250 255
Ile Thr Tyr Lys Ser Leu
260
<210> 432
<211> 262
<212> PRT
<213> RESISTANCE GENE
<400> 432
Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser Ala Cys Ser Pro Tyr Ile
1 5 10 15
Val Ser Ala Asn Pro Asn His Ser Ala Ser Lys Ser Asp Glu Lys Ala
20 25 30
Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala His Thr Thr Gly Val Leu
35 40 45
Val Ile Gln Gln Gly Gln Thr Gln Gln Ser Tyr Gly Asn Asp Leu Ala
50 55 60
Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser Thr Phe Lys Met Leu Asn
65 70 75 80
Ala Leu Ile Gly Leu Glu His His Lys Ala Thr Thr Thr Glu Val Phe
85 90 95
Lys Trp Asp Gly Gln Lys Arg Leu Phe Pro Glu Trp Glu Lys Asn Met
100 105 110
Thr Leu Gly Asp Ala Met Lys Ala Ser Ala Ile Pro Val Tyr Gln Asp
115 120 125
Leu Ala Arg Arg Ile Gly Leu Glu Leu Met Ser Asn Glu Val Lys Arg
130 135 140
Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr Gln Val Asp Asn Phe Trp
145 150 155 160
Leu Val Gly Pro Leu Lys Ile Thr Pro Gln Gln Glu Ala Gln Phe Ala
165 170 175
Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe Ser Gln Lys Val Gln Asp
180 185 190
Glu Val Gln Ser Met Leu Phe Ile Glu Glu Lys Asn Gly Asn Lys Ile
195 200 205
Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val Asn Pro Gln Val Gly Trp
210 215 220
Leu Thr Glu Trp Val Val Gln Pro Gln Gly Asn Ile Val Ala Phe Ser
225 230 235 240
Leu Asn Leu Glu Met Lys Lys Gly Ile Pro Ser Ser Val Arg Lys Glu
245 250 255
Ile Thr Tyr Lys Ser Leu
260
<210> 433
<211> 275
<212> PRT
<213> RESISTANCE GENE
<400> 433
Met Thr Val Arg Arg Leu Ser Cys Ala Leu Gly Ala Ala Leu Ser Leu
1 5 10 15
Ser Ala Leu Gly Gly Gly Pro Val Gln Ala Ala Val Leu Cys Thr Val
20 25 30
Val Ala Asp Ala Ala Asp Gly Arg Ile Leu Phe Gln Gln Gly Thr Gln
35 40 45
Gln Ala Cys Ala Glu Arg Tyr Thr Pro Ala Ser Thr Phe Lys Leu Ala
50 55 60
Ile Ala Leu Met Gly Ala Asp Ala Gly Ile Leu Gln Gly Pro His Glu
65 70 75 80
Pro Val Trp Asn Tyr Gln Pro Ala Tyr Pro Asp Trp Gly Gly Asp Ala
85 90 95
Trp Arg Gln Pro Thr Asp Pro Ala Arg Trp Ile Lys Tyr Ser Val Val
100 105 110
Trp Tyr Ser Gln Leu Thr Ala Lys Ala Leu Gly Gln Asp Arg Phe Gln
115 120 125
Arg Tyr Thr Ser Ala Phe Gly Tyr Gly Asn Ala Asp Val Ser Gly Glu
130 135 140
Pro Gly Lys His Asn Gly Thr Asp Gly Ala Trp Ile Ile Ser Ser Leu
145 150 155 160
Arg Ile Ser Pro Leu Glu Gln Leu Ala Phe Leu Arg Lys Leu Val Asn
165 170 175
Arg Gln Leu Pro Val Lys Ala Ala Ala Tyr Glu Leu Ala Glu Asn Leu
180 185 190
Phe Glu Ala Gly Gln Ala Asp Gly Trp Arg Leu Tyr Gly Lys Thr Gly
195 200 205
Thr Gly Ser Pro Gly Ser Asn Gly Val Tyr Thr Ala Ala Asn Ala Tyr
210 215 220
Gly Trp Phe Val Gly Trp Ala Arg Lys Asp Gly Arg Gln Leu Val Tyr
225 230 235 240
Ala Arg Leu Leu Gln Asp Glu Arg Ala Thr Arg Pro Asn Ala Gly Leu
245 250 255
Arg Ala Arg Asp Glu Leu Val Arg Asp Trp Pro Ala Met Ala Gly Ala
260 265 270
Trp Arg Pro
275
<210> 434
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 434
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Ser Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Glu Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Val Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Gln Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asn Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Asn Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Glu Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asn Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 435
<211> 266
<212> PRT
<213> RESISTANCE GENE
<400> 435
Met Lys Thr Phe Ala Ala Tyr Val Ile Ile Ala Cys Leu Ser Ser Thr
1 5 10 15
Ala Leu Ala Gly Ser Ile Thr Glu Asn Thr Ser Trp Asn Lys Glu Phe
20 25 30
Ser Ala Glu Ala Val Asn Gly Val Phe Val Leu Cys Lys Ser Ser Ser
35 40 45
Lys Ser Cys Ala Thr Asn Asp Leu Ala Arg Ala Ser Lys Glu Tyr Leu
50 55 60
Pro Ala Ser Thr Phe Lys Ile Pro Ser Ala Ile Ile Gly Leu Glu Thr
65 70 75 80
Gly Val Ile Lys Asn Glu His Gln Val Phe Lys Trp Asp Gly Lys Pro
85 90 95
Arg Ala Met Lys Gln Trp Glu Arg Asp Leu Thr Leu Arg Gly Ala Ile
100 105 110
Gln Val Ser Ala Val Pro Val Phe Gln Gln Ile Ala Arg Glu Val Gly
115 120 125
Glu Val Arg Met Gln Lys Tyr Leu Lys Lys Phe Ser Tyr Gly Asn Gln
130 135 140
Asn Ile Ser Gly Gly Ile Asp Lys Phe Trp Leu Glu Asp Gln Leu Arg
145 150 155 160
Ile Ser Ala Val Asn Gln Val Glu Phe Leu Glu Ser Leu Tyr Leu Asn
165 170 175
Lys Leu Ser Ala Ser Lys Glu Asn Gln Leu Ile Val Lys Glu Ala Leu
180 185 190
Val Thr Glu Ala Ala Pro Glu Tyr Leu Val His Ser Lys Thr Gly Phe
195 200 205
Ser Gly Val Gly Thr Glu Ser Asn Pro Gly Val Ala Trp Trp Val Gly
210 215 220
Trp Val Glu Lys Glu Thr Glu Val Tyr Phe Phe Ala Phe Asn Met Asp
225 230 235 240
Ile Asp Asn Glu Ser Lys Leu Pro Leu Arg Lys Ser Ile Pro Thr Lys
245 250 255
Ile Met Glu Ser Glu Gly Ile Ile Gly Gly
260 265
<210> 436
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 436
Met Asn Ile Lys Thr Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Val Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Lys Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Val Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asn Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 437
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 437
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Thr Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Glu Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Lys Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Thr Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asp Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 438
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 438
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Val Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Lys Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Val Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asn Gln Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 439
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 439
Met Asn Ile Lys Thr Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Glu Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Val
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Gln Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Pro Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asp Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Met Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 440
<211> 273
<212> PRT
<213> RESISTANCE GENE
<400> 440
Met Asn Lys Tyr Phe Thr Cys Tyr Val Val Ala Ser Leu Phe Phe Ser
1 5 10 15
Gly Cys Thr Val Gln His Asn Leu Ile Asn Glu Thr Gln Ser Gln Ile
20 25 30
Val Gln Gly His Asn Gln Val Ile His Gln Tyr Phe Asp Glu Lys Asn
35 40 45
Thr Ser Gly Val Leu Val Ile Gln Thr Asp Lys Lys Ile Asn Leu Tyr
50 55 60
Gly Asn Ala Leu Ser Arg Ala Asn Thr Glu Tyr Val Pro Ala Ser Thr
65 70 75 80
Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu Asn Gln Lys Thr Asp
85 90 95
Ile Asn Glu Ile Phe Lys Trp Lys Gly Glu Lys Arg Ser Phe Thr Thr
100 105 110
Trp Glu Lys Asp Met Thr Leu Gly Glu Ala Met Lys Leu Ser Ala Val
115 120 125
Pro Val Tyr Gln Glu Leu Ala Arg Arg Ile Gly Leu Asp Leu Met Gln
130 135 140
Lys Glu Val Glu Arg Ile Asp Phe Gly Asn Ala Glu Ile Gly Gln Gln
145 150 155 160
Val Asp Asn Phe Trp Leu Ile Gly Pro Leu Lys Val Thr Pro Ile Gln
165 170 175
Glu Val Glu Phe Val Ser Gln Leu Ala His Thr Gln Leu Pro Phe Ser
180 185 190
Glu Lys Val Gln Ala Asn Val Lys Asn Met Leu Leu Leu Glu Glu Asn
195 200 205
Asn Gly Tyr Lys Ile Phe Gly Lys Thr Gly Trp Ala Met Asp Ile Lys
210 215 220
Pro Gln Val Gly Trp Leu Thr Gly Trp Val Glu Gln Pro Asp Gly Lys
225 230 235 240
Ile Val Ala Phe Ala Leu Asn Met Glu Met Arg Ser Glu Met Pro Ala
245 250 255
Ser Ile Arg Asn Glu Leu Leu Met Lys Ser Leu Lys Gln Leu Asn Ile
260 265 270
Ile
<210> 441
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 441
Met Asn Lys Tyr Phe Thr Cys Tyr Val Val Ala Ser Leu Phe Leu Ser
1 5 10 15
Gly Cys Thr Val Gln His Asn Leu Ile Asn Glu Thr Pro Ser Gln Ile
20 25 30
Val Gln Gly His Asn Gln Val Ile His Gln Tyr Phe Asp Glu Lys Asn
35 40 45
Thr Ser Gly Val Leu Val Ile Gln Thr Asp Lys Lys Ile Asn Leu Tyr
50 55 60
Gly Asn Ala Leu Ser Arg Ala Asn Thr Glu Tyr Val Pro Ala Ser Thr
65 70 75 80
Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu Asn Gln Lys Thr Asp
85 90 95
Ile Asn Glu Ile Phe Lys Trp Lys Gly Glu Lys Arg Ser Phe Thr Ala
100 105 110
Trp Glu Lys Asp Met Thr Leu Gly Glu Ala Met Lys Leu Ser Ala Val
115 120 125
Pro Val Tyr Gln Glu Leu Ala Arg Arg Ile Gly Leu Asp Leu Met Gln
130 135 140
Lys Glu Val Lys Arg Ile Gly Phe Gly Asn Ala Glu Ile Gly Gln Gln
145 150 155 160
Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Val Thr Pro Ile Gln
165 170 175
Glu Val Glu Phe Val Ser Gln Leu Ala His Thr Gln Leu Pro Phe Ser
180 185 190
Glu Lys Val Gln Ala Asn Val Lys Asn Met Leu Leu Leu Glu Glu Ser
195 200 205
Asn Gly Tyr Lys Ile Phe Gly Lys Thr Gly Trp Ala Ala Met Asp Ile
210 215 220
Lys Pro Gln Val Gly Trp Leu Thr Gly Trp Val Glu Gln Pro Asp Gly
225 230 235 240
Lys Ile Val Ala Phe Ala Leu Asn Met Glu Met Arg Ser Glu Met Pro
245 250 255
Ala Ser Ile Arg Asn Glu Leu Leu Met Lys Ser Leu Lys Gln Leu Asn
260 265 270
Ile Ile
<210> 442
<211> 266
<212> PRT
<213> RESISTANCE GENE
<400> 442
Met Lys Thr Phe Ala Ala Tyr Val Ile Thr Ala Cys Leu Ser Ser Thr
1 5 10 15
Ala Leu Ala Ser Ser Ile Thr Glu Asn Thr Ser Trp Asn Lys Glu Phe
20 25 30
Ser Ala Glu Ala Val Asn Gly Val Phe Val Leu Cys Lys Ser Ser Ser
35 40 45
Lys Ser Cys Ala Thr Asn Asn Leu Ala Arg Ala Ser Lys Glu Tyr Leu
50 55 60
Pro Ala Ser Thr Phe Lys Ile Pro Asn Ala Ile Ile Gly Leu Glu Thr
65 70 75 80
Gly Val Ile Lys Asn Glu His Gln Val Phe Lys Trp Asp Gly Lys Pro
85 90 95
Arg Ala Met Lys Gln Trp Glu Arg Asp Leu Ser Leu Arg Gly Ala Ile
100 105 110
Gln Val Ser Ala Val Pro Val Phe Gln Gln Ile Ala Arg Glu Val Gly
115 120 125
Glu Val Arg Met Gln Lys Tyr Leu Lys Lys Phe Ser Tyr Gly Asn Gln
130 135 140
Asn Ile Ser Gly Gly Ile Asp Lys Phe Leu Leu Glu Gly Gln Leu Arg
145 150 155 160
Ile Ser Ala Val Asn Gln Val Glu Phe Leu Glu Ser Leu Phe Leu Asn
165 170 175
Lys Leu Ser Ala Ser Lys Glu Asn Gln Leu Ile Val Lys Glu Ala Leu
180 185 190
Val Thr Glu Ala Ala Pro Glu Tyr Leu Val His Ser Lys Thr Gly Phe
195 200 205
Ser Gly Val Gly Thr Glu Ser Asn Pro Gly Val Ala Trp Trp Val Gly
210 215 220
Trp Val Glu Lys Gly Thr Glu Val Tyr Phe Phe Ala Phe Asn Met Asp
225 230 235 240
Ile Asp Asn Glu Asn Lys Leu Pro Leu Arg Lys Ser Ile Pro Thr Lys
245 250 255
Ile Met Ala Ser Glu Gly Ile Ile Gly Gly
260 265
<210> 443
<211> 275
<212> PRT
<213> RESISTANCE GENE
<400> 443
Met Ala Ile Arg Ile Phe Ala Ile Leu Phe Ser Ile Phe Ser Leu Ala
1 5 10 15
Thr Phe Ala His Ala Gln Glu Gly Thr Leu Glu Arg Ser Asp Trp Arg
20 25 30
Lys Phe Phe Ser Glu Phe Gln Ala Lys Gly Thr Ile Val Val Ala Asp
35 40 45
Glu Arg Gln Ala Asp Arg Ala Met Leu Val Phe Asp Pro Val Arg Ser
50 55 60
Lys Lys Arg Tyr Ser Pro Ala Ser Thr Phe Lys Ile Pro His Thr Leu
65 70 75 80
Phe Ala Leu Asp Ala Gly Ala Val Arg Asp Glu Phe Gln Ile Phe Arg
85 90 95
Trp Asp Gly Val Asn Arg Gly Phe Ala Gly His Asn Gln Asp Gln Asp
100 105 110
Leu Arg Ser Ala Met Arg Asn Ser Thr Val Trp Val Tyr Glu Leu Phe
115 120 125
Ala Lys Glu Ile Gly Asp Asp Lys Ala Arg Arg Tyr Leu Lys Lys Ile
130 135 140
Asp Tyr Gly Asp Ala Asp Pro Ser Thr Ser Asn Gly Asp Tyr Trp Ile
145 150 155 160
Glu Gly Ser Leu Ala Ile Ser Ala Gln Glu Gln Ile Ala Phe Leu Arg
165 170 175
Lys Leu Tyr Arg Asn Glu Leu Pro Phe Arg Val Glu His Gln Arg Leu
180 185 190
Val Lys Asp Leu Met Ile Val Glu Ala Gly Arg Asn Trp Ile Leu Arg
195 200 205
Ala Lys Thr Gly Trp Glu Gly Arg Met Gly Trp Trp Val Gly Trp Val
210 215 220
Glu Trp Pro Thr Gly Ser Val Phe Phe Ala Leu Asn Ile Asp Thr Pro
225 230 235 240
Asn Arg Met Asp Asp Leu Phe Lys Arg Glu Ala Ile Val Arg Ala Ile
245 250 255
Leu Arg Ser Ile Glu Ala Leu Pro Pro Asn Pro Ala Val Asn Ser Asp
260 265 270
Ala Ala Arg
275
<210> 444
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 444
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Lys Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Ser Thr Thr Glu Val Phe Lys Trp Asn Gly Gln Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Asn Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln Asp Glu Val Lys Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asp Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 445
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 445
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Ser Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Glu Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Gln Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asn Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Asn Glu Val Lys His Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Pro Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asn Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 446
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 446
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Ser Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Glu Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Gln Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asn Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Asn Glu Val Lys His Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asn Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 447
<211> 275
<212> PRT
<213> RESISTANCE GENE
<400> 447
Met Lys Lys Phe Ile Leu Pro Ile Leu Ser Ile Ser Thr Leu Leu Ser
1 5 10 15
Val Ser Ala Cys Ser Ser Ile Gln Thr Lys Phe Glu Asp Thr Phe His
20 25 30
Thr Ser Asn Gln Gln His Glu Lys Ala Ile Lys Ser Tyr Phe Asp Glu
35 40 45
Ala Gln Thr Gln Gly Val Ile Ile Ile Lys Lys Gly Lys Asn Ile Ser
50 55 60
Thr Tyr Gly Asn Asn Leu Thr Arg Ala His Thr Glu Tyr Val Pro Ala
65 70 75 80
Ser Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu Asn His Lys
85 90 95
Ala Thr Thr Thr Glu Ile Phe Lys Trp Asp Gly Lys Lys Arg Ser Tyr
100 105 110
Pro Met Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Met Ala Leu Ser
115 120 125
Ala Val Pro Val Tyr Gln Glu Leu Ala Arg Arg Thr Gly Leu Asp Leu
130 135 140
Met Gln Lys Glu Val Lys Arg Val Gly Phe Gly Asn Met Asn Ile Gly
145 150 155 160
Thr Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro
165 170 175
Ile Gln Glu Val Asn Phe Ala Asp Asp Phe Ala Asn Asn Arg Leu Pro
180 185 190
Phe Lys Leu Glu Thr Gln Glu Glu Val Lys Lys Met Leu Leu Ile Lys
195 200 205
Glu Phe Asn Gly Ser Lys Ile Tyr Ala Lys Ser Gly Trp Gly Met Asp
210 215 220
Val Thr Pro Gln Val Gly Trp Leu Thr Gly Trp Val Glu Lys Ser Asn
225 230 235 240
Gly Glu Lys Val Ala Phe Ser Leu Asn Ile Glu Met Lys Gln Gly Met
245 250 255
Pro Gly Ser Ile Arg Asn Glu Ile Thr Tyr Lys Ser Leu Glu Asn Leu
260 265 270
Gly Ile Ile
275
<210> 448
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 448
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Ser Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Glu Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Gln Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asn Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Asn Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Glu Val Gln Asp Glu Val Gln Ser Ile Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asn Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 449
<211> 275
<212> PRT
<213> RESISTANCE GENE
<400> 449
Met Lys Lys Phe Ile Leu Pro Ile Phe Ser Ile Ser Ile Leu Val Ser
1 5 10 15
Leu Ser Ala Cys Ser Ser Ile Lys Thr Lys Ser Glu Asp Asn Phe His
20 25 30
Ile Ser Ser Gln Gln His Glu Lys Ala Ile Lys Ser Tyr Phe Asp Glu
35 40 45
Ala Gln Thr Gln Gly Val Ile Ile Ile Lys Glu Gly Lys Asn Leu Ser
50 55 60
Thr Tyr Gly Asn Ala Leu Ala Arg Ala Asn Lys Glu Tyr Val Pro Ala
65 70 75 80
Ser Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu Asn His Lys
85 90 95
Ala Thr Thr Asn Glu Ile Phe Lys Trp Asp Gly Lys Lys Arg Thr Tyr
100 105 110
Pro Met Trp Glu Lys Asp Met Thr Leu Gly Glu Ala Met Ala Leu Ser
115 120 125
Ala Val Pro Val Tyr Gln Glu Leu Ala Arg Arg Thr Gly Leu Glu Leu
130 135 140
Met Gln Lys Glu Val Lys Arg Val Asn Phe Gly Asn Thr Asn Ile Gly
145 150 155 160
Thr Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro
165 170 175
Val Gln Glu Val Asn Phe Ala Asp Asp Leu Ala His Asn Arg Leu Pro
180 185 190
Phe Lys Leu Glu Thr Gln Glu Glu Val Lys Lys Met Leu Leu Ile Lys
195 200 205
Glu Val Asn Gly Ser Lys Ile Tyr Ala Lys Ser Gly Trp Gly Met Gly
210 215 220
Val Thr Ser Gln Val Gly Trp Leu Thr Gly Trp Val Glu Gln Ala Asn
225 230 235 240
Gly Lys Lys Ile Pro Phe Ser Leu Asn Leu Glu Met Lys Glu Gly Met
245 250 255
Ser Gly Ser Ile Arg Asn Glu Ile Thr Tyr Lys Ser Leu Glu Asn Leu
260 265 270
Gly Ile Ile
275
<210> 450
<211> 265
<212> PRT
<213> RESISTANCE GENE
<400> 450
Met Arg Val Leu Ala Leu Ser Ala Val Phe Leu Val Ala Ser Ile Ile
1 5 10 15
Gly Met Pro Ala Val Ala Lys Glu Trp Gln Glu Asn Lys Ser Trp Asn
20 25 30
Ala His Phe Thr Glu His Lys Ser Gln Gly Val Val Val Leu Trp Asn
35 40 45
Glu Asn Lys Gln Gln Gly Phe Thr Asn Asn Leu Lys Arg Ala Asn Gln
50 55 60
Ala Phe Leu Pro Ala Ser Thr Phe Lys Ile Pro Asn Ser Leu Ile Ala
65 70 75 80
Leu Asp Leu Gly Val Val Lys Asp Glu His Gln Val Phe Lys Trp Asp
85 90 95
Gly Gln Thr Arg Asp Ile Ala Thr Trp Asn Arg Asp His Asn Leu Ile
100 105 110
Thr Ala Met Lys Tyr Ser Val Val Pro Val Tyr Gln Glu Phe Ala Arg
115 120 125
Gln Ile Gly Glu Ala Arg Met Ser Lys Met Leu His Ala Phe Asp Tyr
130 135 140
Gly Asn Glu Asp Ile Ser Gly Asn Val Asp Ser Phe Trp Leu Asp Gly
145 150 155 160
Gly Ile Arg Ile Ser Ala Thr Glu Gln Ile Ser Phe Leu Arg Lys Leu
165 170 175
Tyr His Asn Lys Leu His Val Ser Glu Arg Ser Gln Arg Ile Val Lys
180 185 190
Gln Ala Met Leu Thr Glu Ala Asn Gly Asp Tyr Ile Ile Arg Ala Lys
195 200 205
Thr Gly Tyr Ser Ala Arg Ile Glu Pro Lys Ile Gly Trp Trp Val Gly
210 215 220
Trp Val Glu Leu Asp Asp Asn Val Trp Phe Phe Ala Met Asn Met Asp
225 230 235 240
Met Pro Thr Ser Asp Gly Leu Gly Leu Arg Gln Ala Ile Thr Lys Glu
245 250 255
Val Leu Lys Gln Glu Lys Ile Ile Pro
260 265
<210> 451
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 451
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Val Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Lys Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Val Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Leu Asp Val
210 215 220
Asn Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 452
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 452
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Val Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Lys Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Val Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Leu Asp Val
210 215 220
Asn Leu Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 453
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 453
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Val Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Lys Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Val Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asn Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Lys Leu Gly
260 265 270
Ile Leu
<210> 454
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 454
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Val Lys Ala Glu Lys Ile Arg Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Lys Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Val Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asn Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 455
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 455
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Val Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Ser Lys Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Val Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asn Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 456
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 456
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Val Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Lys Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Val Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln Asp Gly Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asn Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 457
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 457
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Val Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Ser Lys Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Leu Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asn Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 458
<211> 280
<212> PRT
<213> RESISTANCE GENE
<400> 458
Met Lys Leu Leu Lys Ile Leu Ser Leu Val Cys Leu Ser Ile Ser Ile
1 5 10 15
Gly Ala Cys Ala Glu His Ser Met Ser Arg Ala Lys Thr Ser Thr Ile
20 25 30
Pro Gln Val Asn Asn Ser Ile Ile Asp Gln Asn Val Gln Ala Leu Phe
35 40 45
Asn Glu Ile Ser Ala Asp Ala Val Phe Val Thr Tyr Asp Gly Gln Asn
50 55 60
Ile Lys Lys Tyr Gly Thr His Leu Asp Arg Ala Lys Thr Ala Tyr Ile
65 70 75 80
Pro Ala Ser Thr Phe Lys Ile Ala Asn Ala Leu Ile Gly Leu Glu Asn
85 90 95
His Lys Ala Thr Ser Thr Glu Ile Phe Lys Trp Asp Gly Lys Pro Arg
100 105 110
Phe Leu Lys Ala Trp Asp Lys Asp Phe Thr Leu Gly Glu Ala Met Gln
115 120 125
Ala Ser Thr Val Pro Val Tyr Gln Glu Leu Ala Arg Arg Ile Gly Pro
130 135 140
Ser Leu Met Gln Ser Glu Leu Gln Arg Ile Gly Tyr Gly Asn Met Gln
145 150 155 160
Ile Gly Thr Glu Val Asp Gln Phe Trp Leu Lys Gly Pro Leu Thr Ile
165 170 175
Thr Pro Ile Gln Glu Val Lys Phe Val Tyr Asp Leu Ala Gln Gly Gln
180 185 190
Leu Pro Phe Lys Pro Glu Val Gln Gln Gln Val Lys Glu Met Leu Tyr
195 200 205
Val Glu Arg Arg Gly Glu Asn Arg Leu Tyr Ala Lys Ser Gly Trp Gly
210 215 220
Met Ala Val Asp Pro Gln Val Gly Trp Tyr Val Gly Phe Val Glu Lys
225 230 235 240
Ala Asp Gly Gln Val Val Ala Phe Ala Leu Asn Met Gln Met Lys Ala
245 250 255
Gly Asp Asp Ile Ala Leu Arg Lys Gln Leu Ser Leu Asp Val Leu Asp
260 265 270
Lys Leu Gly Val Phe His Tyr Leu
275 280
<210> 459
<211> 273
<212> PRT
<213> RESISTANCE GENE
<400> 459
Met Asn Lys Tyr Phe Thr Cys Tyr Val Val Ala Ser Leu Phe Leu Ser
1 5 10 15
Gly Cys Thr Val Gln His Asn Leu Ile Asn Glu Thr Pro Ser Gln Ile
20 25 30
Val Gln Gly His Asn Gln Val Ile His Gln Tyr Phe Asp Glu Lys Asn
35 40 45
Thr Ser Gly Val Leu Val Ile Gln Thr Asp Lys Lys Ile Asn Leu Tyr
50 55 60
Gly Asn Ala Leu Ser Arg Ala Asn Thr Glu Tyr Val Pro Ala Ser Thr
65 70 75 80
Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu Asn Gln Lys Thr Asp
85 90 95
Ile Asn Glu Ile Phe Lys Trp Lys Gly Glu Lys Arg Ser Phe Thr Ala
100 105 110
Trp Glu Lys Asp Met Thr Leu Gly Glu Ala Met Lys Leu Ser Ala Val
115 120 125
Pro Val Tyr Gln Glu Leu Ala Arg Arg Ile Gly Leu Asp Leu Met Gln
130 135 140
Lys Glu Val Lys Arg Ile Gly Phe Gly Asn Ala Glu Ile Gly Gln Gln
145 150 155 160
Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Val Thr Pro Ile Gln
165 170 175
Glu Val Glu Phe Val Ser Gln Leu Ala His Thr Gln Leu Pro Phe Ser
180 185 190
Glu Lys Val Gln Ala Asn Val Lys Asn Met Leu Leu Leu Glu Glu Ser
195 200 205
Asn Gly Tyr Lys Ile Phe Gly Lys Thr Gly Trp Ala Met Asp Val Lys
210 215 220
Pro Gln Val Gly Trp Leu Thr Gly Trp Val Glu Gln Pro Asp Gly Lys
225 230 235 240
Ile Val Ala Phe Ala Leu Asn Met Glu Met Arg Ser Glu Met Pro Ala
245 250 255
Ser Ile Arg Asn Glu Leu Leu Met Lys Ser Leu Lys Gln Leu Asn Ile
260 265 270
Ile
<210> 460
<211> 273
<212> PRT
<213> RESISTANCE GENE
<400> 460
Met Asn Lys Tyr Phe Thr Cys Tyr Val Val Ala Ser Leu Phe Leu Ser
1 5 10 15
Gly Cys Thr Val Gln His Asn Leu Ile Asn Glu Thr Pro Ser Gln Ile
20 25 30
Val Gln Gly His Asn Gln Val Ile His Gln Tyr Phe Asp Glu Lys Asn
35 40 45
Thr Ser Gly Ala Leu Val Ile Gln Thr Asp Lys Lys Ile Asn Leu Tyr
50 55 60
Gly Asn Ala Leu Ser Arg Ala Asn Thr Glu Tyr Val Pro Ala Ser Thr
65 70 75 80
Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu Asn Gln Lys Thr Asp
85 90 95
Ile Asn Glu Ile Phe Lys Trp Lys Gly Glu Lys Arg Ser Phe Thr Ala
100 105 110
Trp Glu Lys Asp Met Thr Leu Gly Glu Ala Met Lys Leu Ser Ala Val
115 120 125
Pro Val Tyr Gln Glu Leu Ala Arg Arg Ile Gly Leu Asp Leu Met Gln
130 135 140
Lys Glu Val Lys Arg Ile Gly Phe Gly Asn Ala Glu Ile Gly Gln Gln
145 150 155 160
Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Val Thr Pro Ile Gln
165 170 175
Glu Val Glu Phe Val Ser Gln Leu Ala His Thr Gln Leu Pro Phe Ser
180 185 190
Glu Lys Val Gln Ala Asn Val Lys Asn Met Leu Leu Leu Glu Glu Ser
195 200 205
Asn Gly Tyr Lys Ile Phe Gly Lys Thr Gly Trp Ala Met Asp Ile Lys
210 215 220
Pro Gln Val Gly Trp Leu Thr Gly Trp Val Glu Gln Pro Asp Gly Lys
225 230 235 240
Ile Val Ala Phe Ala Leu Asn Met Glu Met Arg Ser Glu Met Pro Ala
245 250 255
Ser Ile Arg Asn Glu Leu Leu Met Lys Ser Leu Lys Gln Leu Asn Ile
260 265 270
Ile
<210> 461
<211> 273
<212> PRT
<213> RESISTANCE GENE
<400> 461
Met Asn Lys Tyr Phe Thr Cys Tyr Val Val Ala Ser Leu Phe Leu Ser
1 5 10 15
Gly Cys Thr Val Gln His Asn Leu Ile Asn Glu Thr Pro Ser Gln Ile
20 25 30
Val Gln Gly His Asn Gln Val Ile His Gln Tyr Phe Asp Glu Lys Asn
35 40 45
Thr Ser Gly Val Leu Val Ile Gln Thr Asp Lys Lys Ile Asn Leu Tyr
50 55 60
Gly Asn Ala Leu Ser Arg Ala Asn Thr Glu Tyr Val Pro Ala Ser Thr
65 70 75 80
Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu Asn Gln Lys Thr Asp
85 90 95
Ile Asn Glu Ile Phe Lys Trp Lys Gly Glu Lys Arg Ser Phe Thr Ala
100 105 110
Trp Glu Lys Asp Met Thr Leu Gly Glu Ala Met Lys Leu Ser Ala Val
115 120 125
Pro Val Tyr Gln Glu Leu Ala Arg Arg Ile Gly Leu Asp Leu Met Gln
130 135 140
Lys Glu Val Lys Arg Ile Gly Phe Gly Asn Ala Glu Ile Gly Gln Gln
145 150 155 160
Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Val Thr Pro Ile Gln
165 170 175
Glu Val Glu Phe Val Ser Gln Leu Ala His Thr Gln Leu Pro Phe Ser
180 185 190
Glu Lys Val Gln Ala Asn Val Lys Asn Met Leu Leu Leu Glu Glu Ser
195 200 205
Asn Gly Tyr Lys Ile Phe Gly Lys Thr Gly Trp Ala Met Asp Ile Lys
210 215 220
Pro Gln Val Gly Trp Leu Thr Gly Trp Val Glu Gln Pro Asp Gly Lys
225 230 235 240
Ile Val Ala Phe Ala Leu Asn Met Glu Met Arg Ser Glu Met Pro Ala
245 250 255
Ser Ile Arg Asn Glu Leu Met Met Lys Ser Leu Lys Gln Leu Asn Ile
260 265 270
Ile
<210> 462
<211> 273
<212> PRT
<213> RESISTANCE GENE
<400> 462
Met Asn Lys Tyr Phe Thr Cys Tyr Val Val Ala Ser Leu Phe Leu Ser
1 5 10 15
Gly Cys Thr Val Gln His Asn Leu Ile Asn Glu Thr Pro Ser Gln Ile
20 25 30
Val Gln Gly His Asn Gln Val Ile His Gln Tyr Phe Asp Glu Lys Asn
35 40 45
Thr Ser Gly Val Leu Val Ile Gln Thr Asp Lys Lys Ile Asn Leu Tyr
50 55 60
Gly Asn Ala Leu Ser Arg Ala Asn Thr Glu Tyr Val Pro Ala Ser Thr
65 70 75 80
Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu Asn Gln Lys Thr Asp
85 90 95
Ile Asn Glu Ile Phe Lys Trp Lys Gly Glu Lys Arg Ser Phe Thr Ala
100 105 110
Trp Glu Lys Asp Met Thr Leu Gly Glu Ala Met Lys Leu Ser Ala Val
115 120 125
Pro Val Tyr Gln Glu Leu Ala Arg Arg Ile Gly Leu Asp Leu Met Gln
130 135 140
Lys Glu Val Lys Arg Ile Gly Phe Gly Asn Ala Glu Ile Gly Gln Gln
145 150 155 160
Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Val Thr Pro Ile Gln
165 170 175
Glu Val Glu Phe Val Ser Gln Leu Ala His Thr Gln Leu Pro Phe Ser
180 185 190
Glu Lys Val Gln Ala Asn Val Lys Asn Met Leu Leu Leu Glu Glu Ser
195 200 205
Asn Gly Tyr Lys Ile Phe Gly Lys Thr Gly Trp Ala Met Asp Ile Lys
210 215 220
Pro Gln Val Gly Trp Leu Ala Gly Trp Val Glu Gln Pro Asp Gly Lys
225 230 235 240
Ile Val Ala Phe Ala Leu Asn Met Glu Met Arg Ser Glu Met Pro Ala
245 250 255
Ser Ile Arg Asn Glu Leu Leu Met Lys Ser Leu Lys Gln Leu Asn Ile
260 265 270
Ile
<210> 463
<211> 273
<212> PRT
<213> RESISTANCE GENE
<400> 463
Met Asn Lys Tyr Phe Thr Cys Tyr Val Val Ala Ser Leu Phe Leu Ser
1 5 10 15
Gly Cys Thr Val Gln His Asn Leu Ile Asn Glu Thr Pro Ser Gln Ile
20 25 30
Val Gln Gly His Asn Gln Val Ile His Gln Tyr Phe Asp Glu Arg Asn
35 40 45
Thr Ser Gly Val Leu Val Ile Gln Thr Asp Lys Lys Ile Asn Leu Tyr
50 55 60
Gly Asn Ala Leu Ser Arg Ala Asn Thr Glu Tyr Val Pro Ala Ser Thr
65 70 75 80
Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu Asn Gln Lys Thr Asp
85 90 95
Ile Asn Glu Ile Phe Lys Trp Lys Gly Glu Lys Arg Ser Phe Thr Ala
100 105 110
Trp Glu Lys Asp Met Thr Leu Gly Glu Ala Met Lys Leu Ser Ala Val
115 120 125
Pro Val Tyr Gln Glu Leu Ala Arg Arg Ile Gly Leu Asp Leu Met Gln
130 135 140
Lys Glu Val Lys Arg Ile Gly Phe Gly Asn Ala Glu Ile Gly Gln Gln
145 150 155 160
Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Val Thr Pro Ile Gln
165 170 175
Glu Val Glu Phe Val Ser Gln Leu Ala His Thr Gln Leu Pro Phe Ser
180 185 190
Glu Lys Val Gln Ala Asn Val Lys Asn Met Leu Leu Leu Glu Glu Ser
195 200 205
Asn Gly Tyr Lys Ile Phe Gly Lys Thr Gly Trp Ala Met Asp Ile Lys
210 215 220
Pro Gln Val Gly Trp Leu Thr Gly Trp Val Glu Gln Pro Asp Gly Lys
225 230 235 240
Ile Val Ala Phe Ala Leu Asn Met Glu Met Arg Ser Glu Met Pro Ala
245 250 255
Ser Ile Arg Asn Glu Leu Leu Met Lys Ser Leu Lys Gln Leu Asn Ile
260 265 270
Ile
<210> 464
<211> 273
<212> PRT
<213> RESISTANCE GENE
<400> 464
Met Asn Lys Tyr Phe Thr Cys Tyr Val Val Ala Ser Leu Phe Leu Ser
1 5 10 15
Gly Cys Thr Val Gln His Asn Leu Ile Asn Glu Thr Pro Ser Gln Ile
20 25 30
Val Gln Gly His Asn Gln Val Ile His Gln Tyr Phe Asp Glu Lys Asn
35 40 45
Thr Ser Gly Val Leu Val Ile Gln Thr Asp Lys Lys Ile Asn Leu Tyr
50 55 60
Gly Asn Ala Leu Ser Arg Ala Asn Thr Glu Tyr Val Pro Ala Ser Thr
65 70 75 80
Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu Asn Gln Lys Thr Asp
85 90 95
Ile Asn Glu Ile Phe Lys Trp Lys Gly Glu Lys Arg Ser Phe Thr Ala
100 105 110
Trp Glu Lys Asp Met Thr Leu Gly Glu Ala Met Lys Leu Ser Ala Val
115 120 125
Pro Val Tyr Gln Glu Leu Ala Arg Arg Ile Gly Leu Asp Leu Met Gln
130 135 140
Lys Glu Val Lys Arg Ile Gly Phe Gly Asn Ala Glu Ile Gly Gln Gln
145 150 155 160
Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Val Thr Pro Ile Gln
165 170 175
Glu Val Glu Phe Val Ser Gln Leu Ala His Thr Gln Leu Pro Phe Ser
180 185 190
Glu Lys Val Gln Ala Asn Val Lys Asn Met Leu Leu Leu Glu Lys Ser
195 200 205
Asn Gly Tyr Lys Ile Phe Gly Lys Thr Gly Trp Ala Met Asp Ile Lys
210 215 220
Pro Gln Val Gly Trp Leu Thr Gly Trp Val Glu Gln Pro Asp Gly Lys
225 230 235 240
Ile Val Ala Phe Ala Leu Asn Met Glu Met Arg Ser Glu Met Pro Ala
245 250 255
Ser Ile Arg Asn Glu Leu Leu Met Lys Ser Leu Lys Gln Leu Asn Ile
260 265 270
Ile
<210> 465
<211> 273
<212> PRT
<213> RESISTANCE GENE
<400> 465
Met Asn Lys Tyr Phe Thr Cys Tyr Val Val Ala Ser Leu Phe Leu Ser
1 5 10 15
Gly Cys Thr Val Gln His Asn Leu Ile Asn Glu Thr Pro Ser Gln Ile
20 25 30
Val Gln Gly His Asn Gln Val Ile His Gln Tyr Phe Asp Glu Lys Asn
35 40 45
Thr Ser Gly Val Leu Val Ile Gln Thr Asp Lys Lys Ile Asn Leu Tyr
50 55 60
Gly Asn Ala Leu Ser Arg Ala Asn Thr Glu Tyr Val Pro Ala Ser Thr
65 70 75 80
Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu Asn Gln Lys Thr Asp
85 90 95
Ile Asn Glu Ile Phe Lys Trp Lys Gly Glu Lys Arg Ser Phe Thr Ala
100 105 110
Trp Glu Lys Asp Met Thr Leu Gly Glu Ala Met Lys Leu Ser Ala Val
115 120 125
Pro Val Tyr Gln Glu Leu Ala Arg Arg Ile Gly Leu Asp Leu Met Gln
130 135 140
Lys Glu Val Lys Arg Ile Gly Phe Gly Asn Ala Glu Ile Gly Gln Gln
145 150 155 160
Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Val Thr Pro Ile Gln
165 170 175
Glu Val Glu Phe Val Ser Gln Leu Ala His Thr Gln Leu Pro Phe Ser
180 185 190
Glu Lys Val Gln Ala Asn Val Lys Asn Met Leu Leu Leu Glu Glu Ser
195 200 205
Asn Gly Tyr Lys Ile Phe Gly Lys Thr Gly Trp Ala Met Asp Ile Lys
210 215 220
Pro Gln Val Gly Trp Leu Thr Gly Trp Val Glu Gln Pro Asp Gly Lys
225 230 235 240
Ile Val Ala Phe Ala Leu Asn Met Glu Met Arg Ser Glu Met Pro Ala
245 250 255
Ser Thr Arg Asn Glu Leu Leu Met Lys Ser Leu Lys Gln Leu Asn Ile
260 265 270
Ile
<210> 466
<211> 275
<212> PRT
<213> RESISTANCE GENE
<400> 466
Met Lys Lys Phe Ile Leu Pro Ile Phe Ser Ile Ser Ile Leu Leu Ser
1 5 10 15
Leu Ser Ala Cys Ser Ser Ile Gln Thr Lys Phe Glu Asp Thr Phe His
20 25 30
Ile Ser Asn Gln Lys His Glu Lys Ala Ile Lys Ser Tyr Phe Asp Glu
35 40 45
Ala Gln Thr Gln Gly Val Ile Ile Ile Lys Glu Gly Lys Asn Ile Ser
50 55 60
Ser Tyr Gly Asn Asn Leu Val Arg Ala His Thr Glu Tyr Val Pro Ala
65 70 75 80
Ser Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu Asn His Lys
85 90 95
Ala Thr Thr Asn Glu Ile Phe Lys Trp Asp Gly Lys Lys Arg Ser Tyr
100 105 110
Pro Met Trp Glu Lys Asp Met Thr Leu Gly Glu Ala Met Ala Leu Ser
115 120 125
Ala Val Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Asn Leu
130 135 140
Met Gln Lys Glu Val Lys Arg Val Gly Phe Gly Asn Met Asn Ile Gly
145 150 155 160
Thr Gln Val Asp Asn Phe Trp Leu Ile Gly Pro Leu Lys Ile Thr Pro
165 170 175
Ile Gln Glu Val Asn Phe Ala Asp Asp Leu Ala Asn Asn Arg Leu Pro
180 185 190
Phe Lys Leu Glu Thr Gln Glu Glu Val Lys Lys Met Leu Leu Ile Lys
195 200 205
Glu Val Asn Gly Ser Lys Ile Tyr Ala Lys Ser Gly Trp Gly Met Asp
210 215 220
Val Ser Pro Gln Val Gly Trp Leu Thr Gly Trp Val Glu Lys Ser Asn
225 230 235 240
Gly Glu Lys Val Ser Phe Ser Leu Asn Ile Glu Met Lys Gln Gly Met
245 250 255
Ser Gly Ser Ile Arg Asn Glu Ile Thr Tyr Lys Ser Leu Glu Asn Leu
260 265 270
Gly Ile Ile
275
<210> 467
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 467
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Glu Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Gln Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Ala Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Pro Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asp Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 468
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 468
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Glu Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Gln Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Ile Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asp Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 469
<211> 273
<212> PRT
<213> RESISTANCE GENE
<400> 469
Met Lys Ile Leu Ile Phe Leu Pro Leu Leu Ser Cys Leu Gly Leu Thr
1 5 10 15
Ala Cys Ser Leu Pro Val Ser Ser Leu Pro Ser Gln Ser Ile Ser Thr
20 25 30
Gln Ala Ile Ala Ser Leu Phe Asp Gln Ala Gln Ser Ser Gly Val Leu
35 40 45
Val Ile Gln Arg Asp Gln Gln Val Gln Val Tyr Gly Asn Asp Leu Asn
50 55 60
Arg Ala Asn Thr Glu Tyr Val Pro Ala Ser Thr Phe Lys Met Leu Asn
65 70 75 80
Ala Leu Ile Gly Leu Gln His Gly Lys Ala Thr Thr Asn Glu Ile Phe
85 90 95
Lys Trp Asp Gly Lys Lys Arg Ser Phe Thr Ala Trp Glu Lys Asp Met
100 105 110
Thr Leu Gly Gln Ala Met Gln Ala Ser Ala Val Pro Val Tyr Gln Glu
115 120 125
Leu Ala Arg Arg Ile Gly Leu Glu Leu Met Gln Gln Glu Val Gln Arg
130 135 140
Ile Gln Phe Gly Asn Gln Gln Ile Gly Gln Gln Val Asp Asn Phe Trp
145 150 155 160
Leu Val Gly Pro Leu Lys Val Thr Pro Lys Gln Glu Val Gln Phe Val
165 170 175
Ser Ala Leu Ala Arg Glu Gln Leu Ala Phe Asp Pro Gln Val Gln Gln
180 185 190
Gln Val Lys Ala Met Leu Phe Leu Gln Glu Arg Lys Ala Tyr Arg Leu
195 200 205
Tyr Val Lys Ser Gly Trp Gly Met Asp Val Glu Pro Gln Val Gly Trp
210 215 220
Leu Thr Gly Trp Val Glu Thr Pro Gln Ala Glu Ile Val Ala Phe Ser
225 230 235 240
Leu Asn Met Gln Met Gln Asn Gly Ile Asp Pro Ala Ile Arg Leu Glu
245 250 255
Ile Leu Gln Gln Ala Leu Ala Glu Leu Gly Leu Tyr Pro Lys Ala Glu
260 265 270
Gly
<210> 470
<211> 262
<212> PRT
<213> RESISTANCE GENE
<400> 470
Met His Lys His Met Ser Lys Leu Phe Ile Ala Phe Leu Ala Phe Leu
1 5 10 15
Leu Ser Val Pro Ala Ala Ala Glu Asp Gln Thr Leu Ala Glu Leu Phe
20 25 30
Ala Gln Gln Gly Ile Asp Gly Thr Ile Val Ile Ser Ser Leu His Asn
35 40 45
Gly Lys Thr Phe Ile His Asn Asp Pro Arg Ala Lys Gln Arg Phe Ser
50 55 60
Thr Ala Ser Thr Phe Lys Ile Leu Asn Thr Leu Ile Ser Leu Glu Glu
65 70 75 80
Lys Ala Ile Ser Gly Lys Asp Asp Val Leu Lys Trp Asp Gly His Ile
85 90 95
Tyr Asp Phe Pro Asp Trp Asn Arg Asp Gln Thr Leu Glu Ser Ala Phe
100 105 110
Lys Val Ser Cys Val Trp Cys Tyr Gln Ala Leu Ala Arg Gln Val Gly
115 120 125
Ala Glu Lys Tyr Arg Asn Tyr Leu Arg Lys Ser Val Tyr Gly Glu Leu
130 135 140
Arg Glu Pro Phe Glu Glu Thr Thr Phe Trp Leu Asp Gly Ser Leu Gln
145 150 155 160
Ile Ser Ala Ile Glu Gln Val Asn Phe Leu Lys Lys Val His Leu Arg
165 170 175
Thr Leu Pro Phe Ser Ala Ser Ser Tyr Glu Thr Leu Arg Gln Ile Met
180 185 190
Leu Ile Glu Gln Thr Pro Ala Phe Thr Leu Arg Ala Lys Thr Gly Trp
195 200 205
Ala Thr Arg Val Lys Pro Gln Val Gly Trp Tyr Val Gly His Val Glu
210 215 220
Thr Pro Thr Asp Val Trp Phe Phe Ala Thr Asn Ile Glu Val Arg Asp
225 230 235 240
Glu Lys Asp Leu Pro Leu Arg Gln Lys Leu Thr Arg Lys Ala Leu Gln
245 250 255
Ala Lys Gly Ile Ile Glu
260
<210> 471
<211> 266
<212> PRT
<213> RESISTANCE GENE
<400> 471
Met Lys Thr Phe Ala Ala Tyr Val Ile Thr Ala Cys Leu Ser Ser Thr
1 5 10 15
Ala Leu Ala Ser Ser Ile Thr Glu Asn Thr Ser Trp Asn Lys Glu Phe
20 25 30
Ser Ala Glu Ala Val Asn Gly Val Phe Val Leu Cys Lys Ser Ser Ser
35 40 45
Lys Ser Cys Ala Thr Asn Asn Leu Ala Arg Ala Ser Lys Glu Tyr Leu
50 55 60
Pro Ala Ser Thr Phe Lys Ile Pro Asn Ala Ile Ile Gly Leu Glu Thr
65 70 75 80
Gly Val Ile Lys Asn Glu His Gln Val Phe Lys Trp Asp Gly Lys Pro
85 90 95
Arg Ala Met Lys Gln Trp Glu Arg Asp Leu Ser Leu Arg Gly Ala Ile
100 105 110
Gln Val Ser Ala Val Pro Val Phe Gln Gln Ile Ala Arg Glu Val Gly
115 120 125
Glu Val Arg Met Gln Lys Tyr Leu Lys Lys Phe Ser Tyr Gly Asn Gln
130 135 140
Asn Ile Ser Gly Gly Thr Asp Lys Phe Trp Leu Glu Asp Gln Leu Arg
145 150 155 160
Ile Ser Ala Val Asn Gln Val Glu Phe Leu Glu Ser Leu Phe Leu Asn
165 170 175
Lys Leu Ser Ala Ser Lys Glu Asn Gln Leu Ile Val Lys Glu Ala Leu
180 185 190
Val Thr Glu Ala Ala Pro Glu Tyr Leu Val His Ser Lys Thr Gly Phe
195 200 205
Ser Gly Val Gly Thr Glu Ser Asn Pro Gly Val Ala Trp Trp Val Gly
210 215 220
Trp Val Glu Lys Gly Thr Glu Val Tyr Phe Phe Ala Phe Asn Met Asp
225 230 235 240
Ile Asp Asn Glu Asn Lys Leu Pro Leu Arg Lys Ser Ile Pro Thr Lys
245 250 255
Ile Met Ala Ser Glu Gly Ile Ile Gly Gly
260 265
<210> 472
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 472
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Glu Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Lys Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Leu Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Leu Asp Val
210 215 220
Asp Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 473
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 473
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Val Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Lys Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Gln Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Val Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asn Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 474
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 474
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Val Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Lys Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Met Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asn Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 475
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 475
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Glu Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Val
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Lys Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asn Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Asn Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asp Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 476
<211> 261
<212> PRT
<213> RESISTANCE GENE
<400> 476
Met Arg Val Leu Ala Leu Ser Ala Val Phe Leu Val Ala Ser Ile Ile
1 5 10 15
Gly Met Pro Ala Val Ala Lys Glu Trp Gln Glu Asn Lys Ser Trp Asn
20 25 30
Ala His Phe Thr Glu His Lys Ser Gln Gly Val Val Val Leu Trp Asn
35 40 45
Glu Asn Lys Gln Gln Gly Phe Thr Asn Asn Leu Lys Arg Ala Asn Gln
50 55 60
Ala Phe Leu Pro Ala Ser Thr Phe Lys Ile Pro Asn Ser Leu Ile Ala
65 70 75 80
Leu Asp Leu Gly Val Val Lys Asp Glu His Gln Val Phe Lys Trp Asp
85 90 95
Gly Gln Thr Arg Asp Ile Ala Thr Trp Asn Arg Asp His Asn Leu Ile
100 105 110
Thr Ala Met Lys Tyr Ser Val Val Pro Val Tyr Gln Glu Phe Ala Arg
115 120 125
Gln Ile Gly Glu Ala Arg Met Ser Lys Met Leu His Ala Phe Asp Tyr
130 135 140
Gly Asn Glu Asp Ile Ser Gly Asn Val Asp Ser Phe Trp Leu Asp Gly
145 150 155 160
Gly Ile Arg Ile Ser Ala Thr Glu Gln Ile Ser Phe Leu Arg Lys Leu
165 170 175
Tyr His Asn Lys Leu His Val Ser Glu Arg Ser Gln Arg Ile Val Lys
180 185 190
Gln Ala Met Leu Thr Glu Ala Asn Gly Asp Tyr Ile Ile Arg Ala Lys
195 200 205
Thr Gly Tyr Asp Thr Lys Ile Gly Trp Trp Val Gly Trp Val Glu Leu
210 215 220
Asp Asp Asn Val Trp Phe Phe Ala Met Asn Met Asp Met Pro Thr Ser
225 230 235 240
Asp Gly Leu Gly Leu Arg Gln Ala Ile Thr Lys Glu Val Leu Lys Gln
245 250 255
Glu Lys Ile Ile Pro
260
<210> 477
<211> 269
<212> PRT
<213> RESISTANCE GENE
<400> 477
Met Ser Lys Lys Asn Phe Ile Leu Ile Phe Ile Phe Val Ile Leu Ile
1 5 10 15
Ser Cys Lys Asn Thr Glu Lys Thr Ser Asn Glu Thr Thr Leu Ile Asp
20 25 30
Asn Ile Phe Thr Asn Ser Asn Ala Glu Gly Thr Leu Val Ile Tyr Asn
35 40 45
Leu Asn Asp Asp Lys Tyr Ile Ile His Asn Lys Glu Arg Ala Glu Gln
50 55 60
Arg Phe Tyr Pro Ala Ser Thr Phe Lys Ile Tyr Asn Ser Leu Ile Gly
65 70 75 80
Leu Asn Glu Lys Ala Val Lys Asp Val Asp Glu Val Phe Tyr Lys Tyr
85 90 95
Asn Gly Glu Lys Val Phe Leu Glu Ser Trp Ala Lys Asp Ser Asn Leu
100 105 110
Arg Tyr Ala Ile Lys Asn Ser Gln Val Pro Ala Tyr Lys Glu Leu Ala
115 120 125
Arg Arg Ile Gly Leu Glu Lys Met Lys Glu Asn Ile Glu Lys Leu Asp
130 135 140
Phe Gly Asn Lys Asn Ile Gly Asp Ser Val Asp Thr Phe Trp Leu Glu
145 150 155 160
Gly Pro Leu Glu Ile Ser Ala Met Glu Gln Val Lys Leu Leu Thr Lys
165 170 175
Leu Ala Gln Asn Glu Leu Pro Tyr Pro Ile Glu Ile Gln Lys Ala Val
180 185 190
Ser Asp Ile Thr Ile Leu Glu Gln Thr Asp Asn Tyr Thr Leu His Gly
195 200 205
Lys Thr Gly Leu Ala Asp Ser Glu Asn Met Thr Thr Glu Pro Ile Gly
210 215 220
Trp Leu Val Gly Trp Leu Glu Glu Asn Asn Asn Ile Tyr Val Phe Ala
225 230 235 240
Leu Asn Ile Asp Asn Ile Asn Ser Asp Asp Leu Ala Lys Arg Ile Asn
245 250 255
Ile Val Lys Glu Ser Leu Lys Ala Leu Asn Leu Leu Lys
260 265
<210> 478
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 478
Met Asn Ile Lys Ala Leu Phe Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Val Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Lys Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Val Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asn Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 479
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 479
Met Asn Ile Lys Ala Leu Phe Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Val Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Lys Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Val Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Ser
180 185 190
Ser Gln Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Met Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asn Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 480
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 480
Met Asn Ile Lys Ala Leu Phe Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Val Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Lys Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Val Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asn Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Ala Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 481
<211> 275
<212> PRT
<213> RESISTANCE GENE
<400> 481
Met Ala Ile Arg Ile Phe Ala Ile Leu Phe Ser Ile Phe Ser Leu Ala
1 5 10 15
Thr Phe Ala His Ala Gln Glu Gly Thr Leu Glu Arg Ser Asp Trp Arg
20 25 30
Lys Phe Phe Ser Glu Phe Gln Ala Lys Gly Thr Ile Val Val Ala Asp
35 40 45
Glu Arg Gln Ala Asp Arg Ala Met Leu Val Phe Asp Pro Val Arg Ser
50 55 60
Lys Lys Arg Tyr Ser Pro Ala Ser Thr Phe Lys Ile Pro His Thr Leu
65 70 75 80
Phe Ala Leu Asp Ala Gly Ala Val Arg Asp Glu Phe Gln Ile Phe Arg
85 90 95
Trp Asp Gly Val Asn Arg Gly Phe Ala Gly His Asn Gln Asp Gln Asp
100 105 110
Leu Arg Ser Ala Met Arg Asn Ser Thr Val Trp Val Tyr Glu Leu Phe
115 120 125
Ala Lys Glu Ile Gly Asp Asp Lys Ala Arg Arg Tyr Leu Lys Lys Ile
130 135 140
Asp Tyr Gly Asn Ala Asp Pro Ser Thr Ser Asn Gly Asp Cys Trp Ile
145 150 155 160
Glu Gly Ser Leu Ala Ile Ser Ala Gln Glu Gln Ile Ala Phe Leu Arg
165 170 175
Lys Leu Tyr Arg Asn Glu Leu Pro Phe Arg Val Glu His Gln Arg Leu
180 185 190
Val Lys Asp Leu Met Ile Val Glu Ala Gly Arg Asn Trp Ile Leu Arg
195 200 205
Ala Lys Thr Gly Trp Glu Gly Arg Met Gly Trp Trp Val Gly Trp Val
210 215 220
Glu Trp Pro Thr Gly Ser Val Phe Phe Ala Leu Asn Ile Asp Thr Pro
225 230 235 240
Asn Arg Met Asp Asp Leu Phe Lys Arg Glu Ala Ile Val Arg Ala Ile
245 250 255
Leu Arg Ser Ile Glu Ala Leu Pro Pro Asn Pro Ala Val Asn Ser Asp
260 265 270
Ala Ala Arg
275
<210> 482
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 482
Met Asn Ile Lys Thr Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Glu Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Val
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Gln Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Val Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Pro Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asp Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 483
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 483
Met Asn Ile Lys Thr Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Glu Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Val
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu Tyr His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Gln Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Pro Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asn Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 484
<211> 266
<212> PRT
<213> RESISTANCE GENE
<400> 484
Met Ala Ile Arg Phe Leu Thr Ile Leu Leu Ser Thr Phe Phe Leu Thr
1 5 10 15
Ser Phe Val His Ala Gln Glu His Val Val Val Arg Ser Asp Trp Lys
20 25 30
Lys Phe Phe Ser Asp Leu Gln Ala Glu Gly Ala Ile Val Ile Ala Asp
35 40 45
Glu Arg Gln Ala Glu His Ala Leu Leu Val Phe Gly Gln Glu Arg Ala
50 55 60
Ala Lys Arg Tyr Ser Pro Ala Ser Thr Phe Lys Leu Pro His Thr Leu
65 70 75 80
Phe Ala Leu Asp Ala Gly Ala Val Arg Asp Glu Phe Gln Val Phe Arg
85 90 95
Trp Asp Gly Val Lys Arg Ser Phe Ala Gly His Asn Gln Asp Gln Asp
100 105 110
Leu Arg Ser Ala Met Arg Asn Ser Ala Val Trp Val Tyr Glu Leu Phe
115 120 125
Ala Lys Glu Ile Gly Glu Asp Asn Ala Arg Arg Tyr Leu Lys Gln Ile
130 135 140
Asp Tyr Gly Asn Ala Asp Pro Ser Thr Ile Lys Gly Asn Tyr Trp Ile
145 150 155 160
Asp Gly Asn Leu Glu Ile Ser Ala His Glu Gln Ile Ser Phe Leu Arg
165 170 175
Lys Leu Tyr Arg Asn Gln Leu Pro Phe Gln Val Glu His Gln Arg Leu
180 185 190
Val Lys Tyr Leu Met Ile Thr Glu Ala Gly Arg Asn Trp Ile Leu Arg
195 200 205
Ala Lys Thr Gly Trp Glu Gly Arg Phe Gly Trp Trp Ile Gly Trp Val
210 215 220
Glu Trp Pro Thr Gly Pro Val Phe Phe Ala Leu Asn Ile Asp Thr Pro
225 230 235 240
Asn Arg Thr Asp Asp Leu Phe Lys Arg Glu Ala Ile Ala Arg Ala Ile
245 250 255
Leu Arg Ser Ile Asp Ala Leu Pro Pro Asn
260 265
<210> 485
<211> 265
<212> PRT
<213> RESISTANCE GENE
<400> 485
Met Arg Val Leu Ala Leu Ser Ala Val Phe Leu Val Ala Ser Ile Ile
1 5 10 15
Gly Met Pro Ala Val Ala Lys Glu Trp Gln Glu Asn Lys Ser Trp Asn
20 25 30
Ala His Phe Thr Glu His Lys Ser Gln Gly Val Val Val Leu Trp Asn
35 40 45
Glu Asn Lys Gln Gln Gly Phe Thr Asn Asn Leu Lys Arg Ala Asn Gln
50 55 60
Ala Phe Leu Pro Ala Ser Thr Phe Lys Ile Pro Asn Ser Leu Ile Ala
65 70 75 80
Leu Asp Leu Gly Val Val Lys Asp Glu His Gln Val Phe Lys Trp Asp
85 90 95
Gly Gln Thr Arg Asp Ile Ala Ala Trp Asn Arg Asp His Asp Leu Ile
100 105 110
Thr Ala Met Lys Tyr Ser Val Val Pro Val Tyr Gln Glu Phe Ala Arg
115 120 125
Gln Ile Gly Glu Ala Arg Met Ser Lys Met Leu His Ala Phe Asp Tyr
130 135 140
Gly Asn Glu Asp Ile Ser Gly Asn Val Asp Ser Phe Trp Leu Asp Gly
145 150 155 160
Gly Ile Arg Ile Ser Ala Thr Gln Gln Ile Ala Phe Leu Arg Lys Leu
165 170 175
Tyr His Asn Lys Leu His Val Ser Glu Arg Ser Gln Arg Ile Val Lys
180 185 190
Gln Ala Met Leu Thr Glu Ala Asn Gly Asp Tyr Ile Ile Arg Ala Lys
195 200 205
Thr Gly Tyr Ser Thr Arg Ile Glu Pro Lys Ile Gly Trp Trp Val Gly
210 215 220
Trp Val Glu Leu Asp Asp Asn Val Trp Phe Phe Ala Met Asn Met Asp
225 230 235 240
Met Pro Thr Ser Asp Gly Leu Gly Leu Arg Gln Ala Ile Thr Lys Glu
245 250 255
Val Leu Lys Gln Glu Lys Ile Ile Pro
260 265
<210> 486
<211> 273
<212> PRT
<213> RESISTANCE GENE
<400> 486
Met Asn Lys Tyr Phe Thr Cys Tyr Val Val Ala Ser Leu Phe Leu Ser
1 5 10 15
Gly Cys Thr Val Gln His Asn Leu Ile Asn Glu Thr Pro Ser Gln Ile
20 25 30
Val Gln Gly His Asn Gln Val Ile His Gln Tyr Phe Asp Glu Lys Asn
35 40 45
Thr Ser Gly Val Leu Val Ile Gln Thr Asp Lys Lys Ile Asn Leu Tyr
50 55 60
Gly Asn Ala Leu Ser Arg Ala Asn Thr Glu Tyr Val Pro Ala Ser Thr
65 70 75 80
Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu Asn Gln Lys Thr Asp
85 90 95
Ile Asn Glu Ile Phe Lys Trp Lys Gly Glu Lys Arg Ser Phe Thr Ala
100 105 110
Trp Glu Lys Asp Met Thr Leu Gly Glu Ala Met Lys Leu Ser Ala Val
115 120 125
Pro Val Tyr Gln Glu Leu Ala Arg Arg Ile Gly Leu Asp Leu Met Gln
130 135 140
Lys Glu Val Lys Arg Ile Gly Phe Gly Asn Ala Glu Ile Gly Gln Gln
145 150 155 160
Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Val Thr Pro Ile Gln
165 170 175
Glu Val Glu Phe Val Ser Gln Leu Ala His Thr Gln Leu Pro Phe Ser
180 185 190
Glu Lys Val Gln Ala Asn Val Lys Asn Met Leu Leu Leu Glu Glu Ser
195 200 205
Asn Gly Tyr Lys Ile Phe Gly Lys Thr Gly Trp Ala Met Asp Ile Lys
210 215 220
Ser Gln Val Gly Trp Leu Thr Gly Trp Val Glu Gln Pro Asp Gly Lys
225 230 235 240
Ile Val Ala Phe Ala Leu Asn Met Glu Met Arg Ser Glu Met Pro Ala
245 250 255
Ser Ile Arg Asn Glu Leu Leu Met Lys Ser Leu Lys Gln Leu Asn Ile
260 265 270
Ile
<210> 487
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 487
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Val Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Lys Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Ser Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asn Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 488
<211> 275
<212> PRT
<213> RESISTANCE GENE
<400> 488
Met Ala Ile Arg Ile Phe Ala Ile Leu Phe Ser Ile Phe Ser Leu Ala
1 5 10 15
Thr Phe Ala His Ala Gln Glu Gly Thr Leu Glu Arg Ser Asp Trp Arg
20 25 30
Lys Phe Phe Ser Glu Phe Gln Ala Lys Gly Thr Ile Val Val Ala Asp
35 40 45
Glu Arg Gln Ala Asp Arg Ala Met Leu Val Phe Asp Pro Val Arg Ser
50 55 60
Lys Lys Arg Tyr Ser Pro Ala Ser Thr Phe Lys Ile Pro His Thr Leu
65 70 75 80
Phe Ala Leu Asp Ala Gly Ala Val Arg Asp Glu Phe Gln Ile Phe Arg
85 90 95
Trp Asp Gly Val Asn Arg Gly Phe Ala Gly His Asn Gln Asp Gln Asp
100 105 110
Leu Arg Ser Ala Met Arg Asn Ser Thr Val Trp Val Tyr Glu Leu Phe
115 120 125
Ala Lys Glu Ile Gly Asp Asp Lys Ala Arg Arg Tyr Leu Lys Lys Ile
130 135 140
Asp Tyr Gly Asn Ala Asp Pro Ser Thr Ser Asn Gly Asp Tyr Trp Ile
145 150 155 160
Glu Gly Ser Leu Ala Ile Ser Ala Gln Glu Gln Ile Ala Phe Leu Arg
165 170 175
Lys Leu Tyr Arg Asn Glu Leu Pro Phe Arg Val Glu His Gln Arg Leu
180 185 190
Val Lys Asp Leu Met Ile Val Glu Ala Gly Arg Asn Trp Ile Leu Arg
195 200 205
Ala Lys Thr Gly Trp Glu Gly Arg Met Gly Trp Trp Val Gly Trp Val
210 215 220
Glu Trp Pro Thr Gly Ser Val Phe Phe Ala Leu Asn Ile Asp Thr Pro
225 230 235 240
Asn Arg Met Asp Asp Leu Phe Lys Arg Glu Ala Ile Val Arg Ala Ile
245 250 255
Leu Arg Ser Ile Glu Ala Leu Pro Pro Asn Pro Ala Val Asn Ser Asp
260 265 270
Ala Ala Arg
275
<210> 489
<211> 267
<212> PRT
<213> RESISTANCE GENE
<400> 489
Met Lys Thr Ile Ala Ala Tyr Leu Val Leu Val Phe Tyr Ala Ser Thr
1 5 10 15
Ala Leu Ser Glu Ser Ile Ser Glu Asn Leu Ala Trp Asn Lys Glu Phe
20 25 30
Ser Ser Glu Ser Val His Gly Val Phe Val Leu Cys Lys Ser Ser Ser
35 40 45
Asn Ser Cys Thr Thr Asn Asn Ala Ala Arg Ala Ser Thr Ala Tyr Ile
50 55 60
Pro Ala Ser Thr Phe Lys Ile Pro Asn Ala Leu Ile Gly Leu Glu Thr
65 70 75 80
Gly Ala Ile Lys Asp Glu Arg Gln Val Phe Lys Trp Asp Gly Lys Pro
85 90 95
Arg Ala Met Lys Gln Trp Glu Lys Asp Leu Lys Leu Arg Gly Ala Ile
100 105 110
Gln Val Ser Ala Val Pro Val Phe Gln Gln Ile Ala Arg Glu Val Gly
115 120 125
Glu Ile Arg Met Gln Lys Tyr Leu Asn Leu Phe Ser Tyr Gly Asn Ala
130 135 140
Asn Ile Gly Gly Gly Ile Asp Lys Phe Trp Leu Glu Gly Gln Leu Arg
145 150 155 160
Ile Ser Ala Phe Asn Gln Val Lys Phe Leu Glu Ser Leu Tyr Leu Asn
165 170 175
Asn Leu Pro Ala Ser Lys Ala Asn Gln Leu Ile Val Lys Glu Ala Ile
180 185 190
Val Thr Glu Ala Thr Pro Glu Tyr Ile Val His Ser Lys Thr Gly Tyr
195 200 205
Ser Gly Val Gly Thr Glu Ser Ser Pro Gly Val Ala Trp Trp Val Gly
210 215 220
Trp Val Glu Lys Gly Thr Glu Val Tyr Phe Phe Ala Phe Asn Met Asp
225 230 235 240
Ile Asp Asn Glu Ser Lys Leu Pro Ser Arg Lys Ser Ile Ser Thr Lys
245 250 255
Ile Met Ala Ser Glu Gly Ile Ile Ile Gly Gly
260 265
<210> 490
<211> 266
<212> PRT
<213> RESISTANCE GENE
<400> 490
Met Lys Thr Phe Ala Ala Tyr Val Ile Thr Ala Cys Leu Ser Ser Thr
1 5 10 15
Ala Leu Ala Ser Ser Ile Thr Glu Asn Thr Phe Trp Asn Lys Glu Phe
20 25 30
Ser Ala Glu Ala Val Asn Gly Val Phe Val Leu Cys Lys Ser Ser Ser
35 40 45
Lys Leu Ala Cys Ala Thr Asn Asn Leu Ala Arg Ala Ser Lys Glu Tyr
50 55 60
Leu Pro Ala Ser Thr Phe Lys Ile Pro Asn Ala Ile Ile Gly Leu Glu
65 70 75 80
Thr Gly Val Ile Lys Asn Glu His Gln Ile Phe Lys Trp Asp Gly Lys
85 90 95
Pro Arg Ala Met Lys Gln Trp Glu Arg Asp Leu Ser Leu Arg Gly Ala
100 105 110
Ile Gln Val Ser Ala Val Pro Val Phe Gln Gln Ile Ala Arg Glu Val
115 120 125
Gly Glu Val Arg Met Gln Lys Tyr Leu Lys Lys Phe Ser Tyr Gly Asn
130 135 140
Gln Asn Ile Ser Gly Gly Ile Asp Lys Phe Trp Leu Glu Gly Gln Leu
145 150 155 160
Arg Ile Ser Ala Val Asn Gln Val Glu Phe Leu Glu Ser Leu Phe Leu
165 170 175
Asn Lys Leu Ser Ala Ser Lys Glu Asn Gln Leu Ile Val Lys Glu Ala
180 185 190
Leu Val Thr Glu Ala Pro Glu Tyr Leu Val His Ser Lys Thr Gly Phe
195 200 205
Ser Gly Val Gly Thr Glu Ser Asn Pro Gly Val Ala Trp Trp Val Gly
210 215 220
Trp Val Glu Lys Gly Ala Glu Val Tyr Phe Phe Ala Phe Asn Met Asp
225 230 235 240
Ile Asp Asn Glu Asn Lys Leu Pro Leu Arg Lys Ser Ile Pro Thr Lys
245 250 255
Ile Met Ala Ser Glu Gly Ile Ile Gly Gly
260 265
<210> 491
<211> 275
<212> PRT
<213> RESISTANCE GENE
<400> 491
Met Ala Ile Arg Ile Phe Ala Ile Leu Phe Ser Thr Phe Val Phe Gly
1 5 10 15
Thr Phe Ala His Ala Gln Glu Gly Met Arg Glu Arg Ser Asp Trp Arg
20 25 30
Lys Phe Phe Ser Glu Phe Gln Ala Lys Gly Thr Ile Val Val Ala Asp
35 40 45
Glu Arg Gln Thr Asp Arg Val Ile Leu Val Phe Asp Gln Val Arg Ser
50 55 60
Glu Lys Arg Tyr Ser Pro Ala Ser Thr Phe Lys Ile Pro His Thr Leu
65 70 75 80
Phe Ala Leu Asp Ala Gly Ala Ala Arg Asp Glu Phe Gln Val Phe Arg
85 90 95
Trp Asp Gly Ile Lys Arg Ser Phe Ala Ala His Asn Gln Asp Gln Asp
100 105 110
Leu Arg Ser Ala Met Arg Asn Ser Thr Val Trp Ile Tyr Glu Leu Phe
115 120 125
Ala Lys Glu Ile Gly Glu Asp Lys Ala Arg Arg Tyr Leu Lys Gln Ile
130 135 140
Asp Tyr Gly Asn Ala Asp Pro Ser Thr Ser Asn Gly Asp Tyr Trp Ile
145 150 155 160
Asp Gly Asn Leu Ala Ile Ala Ala Gln Glu Gln Ile Ala Phe Leu Arg
165 170 175
Lys Leu Tyr His Asn Glu Leu Pro Phe Arg Val Glu His Gln Arg Leu
180 185 190
Val Lys Asp Leu Met Ile Val Glu Ala Gly Arg Asn Trp Ile Leu Arg
195 200 205
Ala Lys Thr Gly Trp Glu Gly Arg Met Gly Trp Trp Val Gly Trp Val
210 215 220
Glu Trp Pro Thr Gly Pro Val Phe Phe Ala Leu Asn Ile Asp Thr Pro
225 230 235 240
Asn Arg Met Asp Asp Leu Phe Lys Arg Glu Ala Ile Val Arg Ala Ile
245 250 255
Leu Arg Ser Ile Glu Ala Leu Pro Pro Asn Pro Ala Val Asn Ser Asp
260 265 270
Ala Ala Arg
275
<210> 492
<211> 266
<212> PRT
<213> RESISTANCE GENE
<400> 492
Met Lys Thr Phe Ala Ala Tyr Val Ile Ile Ala Cys Leu Ser Ser Thr
1 5 10 15
Ala Leu Ala Gly Ser Ile Thr Glu Asn Thr Ser Trp Asn Lys Glu Phe
20 25 30
Ser Ala Glu Ala Val Asn Gly Val Phe Val Leu Cys Lys Ser Ser Ser
35 40 45
Lys Ser Cys Ala Thr Asn Asp Leu Ala Arg Ala Ser Lys Glu Tyr Leu
50 55 60
Pro Ala Ser Thr Phe Lys Ile Pro Asn Ala Ile Ile Gly Leu Glu Thr
65 70 75 80
Gly Val Ile Lys Asn Glu His Gln Val Phe Lys Trp Asp Gly Lys Pro
85 90 95
Arg Ala Met Lys Gln Trp Glu Arg Asp Leu Thr Leu Arg Gly Ala Ile
100 105 110
Gln Val Ser Ala Val Pro Val Phe Gln Gln Ile Ala Arg Glu Val Gly
115 120 125
Glu Val Arg Met Gln Lys Tyr Leu Lys Lys Phe Ser Tyr Gly Ser Gln
130 135 140
Asn Ile Ser Gly Gly Ile Asp Lys Phe Trp Leu Glu Asp Gln Leu Arg
145 150 155 160
Ile Ser Ala Val Asn Gln Val Glu Phe Leu Glu Ser Leu Tyr Leu Asn
165 170 175
Lys Leu Ser Ala Ser Lys Glu Asn Gln Leu Ile Val Lys Glu Ala Leu
180 185 190
Val Thr Glu Ala Ala Pro Glu Tyr Leu Val His Ser Lys Thr Gly Phe
195 200 205
Ser Gly Val Gly Thr Glu Ser Asn Pro Gly Val Ala Trp Trp Val Gly
210 215 220
Trp Val Glu Lys Glu Thr Glu Val Tyr Phe Phe Ala Phe Asn Met Asp
225 230 235 240
Ile Asp Asn Glu Ser Lys Leu Pro Leu Arg Lys Ser Ile Pro Thr Lys
245 250 255
Ile Met Glu Ser Glu Gly Ile Ile Gly Gly
260 265
<210> 493
<211> 273
<212> PRT
<213> RESISTANCE GENE
<400> 493
Met Asn Lys Tyr Phe Thr Cys Tyr Val Val Ala Ser Leu Phe Leu Ser
1 5 10 15
Gly Cys Thr Val Gln His Asn Leu Ile Asn Glu Thr Pro Ser Gln Ile
20 25 30
Val Gln Gly His Asn Gln Val Ile His Gln Tyr Phe Asp Glu Lys Asn
35 40 45
Thr Ser Gly Val Leu Val Ile Gln Thr Asp Lys Lys Ile Asn Leu Tyr
50 55 60
Gly Asn Ala Leu Ser Arg Ala Asn Thr Glu Tyr Val Pro Ala Ser Thr
65 70 75 80
Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu Asn Gln Lys Thr Asp
85 90 95
Ile Asn Glu Ile Phe Lys Trp Lys Gly Glu Lys Arg Ser Phe Thr Ala
100 105 110
Trp Glu Lys Asp Met Thr Leu Gly Glu Ala Met Lys Leu Ser Ala Val
115 120 125
Pro Val Tyr Gln Glu Leu Ala Arg Arg Ile Gly Leu Asp Leu Met Gln
130 135 140
Lys Glu Val Lys Arg Ile Gly Phe Gly Asn Ala Glu Ile Gly Gln Gln
145 150 155 160
Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Val Thr Pro Ile Gln
165 170 175
Glu Val Glu Phe Val Ser Gln Leu Ala His Thr Gln Leu Pro Phe Ser
180 185 190
Glu Lys Val Gln Ala Asn Val Lys Asn Met Leu Leu Leu Glu Glu Ser
195 200 205
Asn Gly Tyr Lys Ile Phe Gly Lys Thr Gly Trp Ala Met Asp Ile Lys
210 215 220
Pro Gln Val Gly Trp Leu Thr Gly Trp Val Glu Gln Pro Asp Gly Lys
225 230 235 240
Ile Val Ala Phe Ala Leu Asn Met Glu Met Arg Ser Glu Met Pro Ala
245 250 255
Ser Ile Arg Asn Glu Leu Leu Met Lys Ser Leu Lys Gln Leu Asn Ile
260 265 270
Ile
<210> 494
<211> 266
<212> PRT
<213> RESISTANCE GENE
<400> 494
Met Lys Lys Leu Ser Val Leu Leu Trp Leu Thr Leu Phe Tyr Cys Gly
1 5 10 15
Thr Ile Trp Ala Gln Ser Thr Cys Phe Leu Val Gln Glu Asn Gln Thr
20 25 30
Val Leu Lys His Glu Gly Lys Asp Cys Asn Lys Arg Phe Ala Pro Glu
35 40 45
Ser Thr Phe Lys Ile Ala Leu Ser Leu Met Gly Phe Asp Ser Gly Ile
50 55 60
Leu Lys Asp Thr Leu Asn Pro Glu Trp Pro Tyr Lys Lys Glu Tyr Glu
65 70 75 80
Leu Tyr Leu Asn Val Trp Lys Tyr Pro His Asn Pro Arg Thr Trp Ile
85 90 95
Arg Asp Ser Cys Val Trp Tyr Ser Gln Val Leu Thr Gln Gln Leu Gly
100 105 110
Met Thr Arg Phe Lys Asn Tyr Val Asp Ala Phe His Tyr Gly Asn Gln
115 120 125
Asp Ile Ser Gly Asp Lys Gly Gln Asn Asn Gly Leu Thr His Ser Trp
130 135 140
Leu Ser Ser Ser Leu Ala Ile Ser Pro Ser Glu Gln Ile Gln Phe Leu
145 150 155 160
Gln Lys Ile Val Asn Lys Lys Leu Ser Val Asn Pro Lys Ala Phe Thr
165 170 175
Met Thr Lys Asp Ile Leu Tyr Ile Gln Glu Leu Ala Gly Gly Trp Lys
180 185 190
Leu Tyr Gly Lys Thr Gly Asn Gly Arg Gln Leu Thr Lys Asp Lys Ser
195 200 205
Gln Lys Leu Ser Leu Gln His Gly Trp Phe Ile Gly Trp Ile Glu Lys
210 215 220
Asp Gly Arg Val Ile Thr Phe Thr Lys His Ile Ala Asp Ser Lys Lys
225 230 235 240
His Val Thr Phe Ala Ser Phe Arg Ala Lys Asn Glu Thr Leu Asn Gln
245 250 255
Leu Phe Tyr Leu Ile Asn Glu Leu Glu Lys
260 265
<210> 495
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 495
Met Asn Ile Lys Thr Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Glu Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Val
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Gln Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Pro Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asp Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 496
<211> 269
<212> PRT
<213> RESISTANCE GENE
<400> 496
Met Lys Phe Arg His Ala Leu Ser Ser Ala Phe Val Leu Leu Gly Cys
1 5 10 15
Ile Ala Ala Ser Ala His Ala Lys Thr Ile Cys Thr Ala Ile Ala Asp
20 25 30
Ala Gly Thr Gly Lys Leu Leu Val Gln Asp Gly Asp Cys Gly Arg Arg
35 40 45
Ala Ser Pro Ala Ser Thr Phe Lys Ile Ala Ile Ser Leu Met Gly Tyr
50 55 60
Asp Ala Gly Phe Leu Arg Asn Glu His Asp Pro Val Leu Pro Tyr Arg
65 70 75 80
Asp Ser Tyr Ile Ala Trp Gly Gly Glu Ala Trp Lys Gln Pro Thr Asp
85 90 95
Pro Thr Arg Trp Leu Lys Tyr Ser Val Val Trp Tyr Ser Gln Gln Val
100 105 110
Ala His His Leu Gly Ala Gln Arg Phe Ala Gln Tyr Ala Lys Ala Phe
115 120 125
Gly Tyr Gly Asn Ala Asp Val Ser Gly Asp Pro Gly Gln Asn Asn Gly
130 135 140
Leu Asp Arg Ala Trp Ile Gly Ser Ser Leu Gln Ile Ser Pro Leu Glu
145 150 155 160
Gln Leu Glu Phe Leu Gly Lys Met Leu Asn Arg Lys Leu Pro Val Ser
165 170 175
Pro Thr Ala Val Asp Met Thr Glu Arg Ile Val Glu Ser Thr Thr Leu
180 185 190
Ala Asp Gly Thr Val Val His Gly Lys Thr Gly Val Ser Tyr Pro Leu
195 200 205
Leu Ala Asp Gly Thr Arg Asp Trp Ala Arg Gly Ser Gly Trp Phe Val
210 215 220
Gly Trp Ile Val Arg Gly Asn Gln Thr Leu Val Phe Ala Arg Leu Thr
225 230 235 240
Gln Asp Glu Arg Lys Gln Pro Val Ser Ala Gly Ile Arg Thr Arg Glu
245 250 255
Ala Phe Leu Arg Asp Leu Pro Arg Leu Leu Ala Ala Arg
260 265
<210> 497
<211> 269
<212> PRT
<213> RESISTANCE GENE
<400> 497
Met Lys Phe Arg His Ala Leu Ser Ser Ala Phe Val Leu Leu Gly Cys
1 5 10 15
Ile Ala Ala Ser Ala His Ala Lys Thr Ile Cys Thr Ala Ile Ala Asp
20 25 30
Ala Gly Thr Gly Lys Leu Leu Val Gln Asp Gly Asp Cys Gly Arg Arg
35 40 45
Ala Ser Pro Ala Ser Thr Phe Lys Ile Ala Ile Ser Leu Met Gly Tyr
50 55 60
Asp Ala Gly Phe Leu Arg Asn Glu His Asp Pro Val Leu Pro Tyr Arg
65 70 75 80
Asp Ser Tyr Ile Ala Trp Gly Gly Glu Ala Trp Lys Gln Pro Thr Asp
85 90 95
Pro Thr Arg Trp Leu Lys Tyr Pro Val Val Trp Tyr Ser Gln Gln Val
100 105 110
Ala His His Leu Gly Ala Gln Arg Phe Ala Gln Tyr Ala Lys Ala Phe
115 120 125
Gly Tyr Gly Asn Ala Asp Val Ser Gly Asp Pro Gly Gln Asn Asn Gly
130 135 140
Leu Asp Arg Ala Trp Ile Gly Ser Ser Leu Gln Ile Ser Pro Leu Glu
145 150 155 160
Gln Leu Glu Phe Leu Gly Lys Met Leu Asn Arg Lys Leu Pro Val Ser
165 170 175
Pro Thr Ala Val Asp Met Thr Glu Arg Ile Val Glu Ser Thr Thr Leu
180 185 190
Ala Asp Gly Thr Val Val His Gly Lys Thr Gly Val Ser Tyr Pro Leu
195 200 205
Leu Ala Asp Gly Thr Arg Asp Trp Ala Arg Gly Ser Gly Trp Phe Val
210 215 220
Gly Trp Ile Val Arg Gly Lys Gln Thr Leu Val Phe Ala Arg Leu Thr
225 230 235 240
Gln Asp Glu Arg Lys Gln Pro Val Ser Ala Gly Ile Arg Thr Arg Glu
245 250 255
Ala Phe Leu Arg Asp Leu Pro Arg Leu Leu Ala Ala Arg
260 265
<210> 498
<211> 264
<212> PRT
<213> RESISTANCE GENE
<400> 498
Met Arg Gly Lys His Thr Val Ile Leu Gly Ala Ala Leu Ser Ala Leu
1 5 10 15
Phe Ala Gly Ala Ala Gly Ala Gln Met Leu Glu Cys Thr Leu Val Ala
20 25 30
Asp Ala Ala Ser Gly Gln Glu Leu Tyr Arg Lys Gly Ala Cys Asp Lys
35 40 45
Ala Phe Ala Pro Met Ser Thr Phe Lys Val Pro Leu Ala Val Met Gly
50 55 60
Tyr Asp Ala Gly Ile Leu Val Asp Ala His Asn Pro Arg Trp Asp Tyr
65 70 75 80
Lys Pro Glu Phe Asn Gly Tyr Lys Phe Gln Gln Lys Thr Thr Asp Pro
85 90 95
Thr Ile Trp Glu Lys Asp Ser Ile Val Trp Tyr Ser Gln Gln Leu Thr
100 105 110
Arg Lys Met Gly Gln Lys Arg Phe Ala Ala Tyr Val Ala Gly Phe Gly
115 120 125
Tyr Gly Asn Gly Asp Ile Ser Gly Glu Pro Gly Lys Ser Asn Gly Leu
130 135 140
Thr His Ser Trp Leu Gly Ser Ser Leu Lys Ile Ser Pro Glu Gly Gln
145 150 155 160
Val Arg Phe Val Arg Asp Leu Leu Ser Ala Lys Leu Pro Ala Ser Lys
165 170 175
Asp Ala Gln Gln Met Thr Val Ser Ile Leu Pro His Phe Ala Ala Gly
180 185 190
Asp Trp Ala Val Gln Gly Lys Thr Gly Thr Gly Ser Phe Ile Asp Ala
195 200 205
Arg Gly Ala Lys Ala Pro Leu Gly Trp Phe Ile Gly Trp Ala Thr His
210 215 220
Glu Glu Arg Arg Val Val Phe Ala Arg Met Thr Ala Gly Gly Lys Lys
225 230 235 240
Gly Glu Gln Pro Ala Gly Pro Ala Ala Arg Asp Ala Phe Leu Lys Ala
245 250 255
Leu Pro Asp Leu Ala Lys Arg Phe
260
<210> 499
<211> 269
<212> PRT
<213> RESISTANCE GENE
<400> 499
Met Lys Phe Arg His Ala Leu Ser Ser Ala Phe Val Leu Leu Gly Cys
1 5 10 15
Ile Ala Ala Ser Ala His Ala Lys Thr Ile Cys Thr Ala Ile Ala Asp
20 25 30
Ala Gly Thr Gly Lys Leu Leu Val Gln Asp Gly Asp Cys Gly Arg Arg
35 40 45
Ala Ser Pro Ala Ser Thr Phe Lys Ile Ala Ile Ser Leu Met Gly Tyr
50 55 60
Asp Ala Gly Phe Leu Arg Asn Glu His Asp Pro Val Leu Pro Tyr Arg
65 70 75 80
Asp Ser Tyr Ile Ala Trp Gly Gly Glu Ala Trp Lys Gln Pro Thr Asp
85 90 95
Pro Thr Arg Trp Leu Lys Tyr Ser Val Val Trp Tyr Ser Gln Gln Val
100 105 110
Ala His His Leu Gly Ala Gln Arg Phe Ala Gln Tyr Ala Lys Ala Phe
115 120 125
Gly Tyr Gly Asn Ala Asp Val Ser Gly Asp Pro Gly Gln Asn Asn Gly
130 135 140
Leu Asp Arg Ala Trp Ile Gly Ser Ser Leu Gln Ile Ser Pro Leu Glu
145 150 155 160
Gln Leu Glu Phe Leu Gly Lys Met Leu Asp Arg Lys Leu Pro Val Ser
165 170 175
Pro Thr Ala Val Asp Met Thr Glu Arg Ile Val Glu Ser Thr Thr Leu
180 185 190
Ala Asp Gly Thr Val Val His Gly Lys Thr Gly Val Ser Tyr Pro Leu
195 200 205
Leu Ala Asp Gly Thr Arg Asp Trp Ala Arg Gly Ser Gly Trp Phe Val
210 215 220
Gly Trp Ile Val Arg Gly Lys Gln Thr Leu Val Phe Ala Arg Leu Thr
225 230 235 240
Gln Asp Glu Arg Lys Gln Pro Val Ser Ala Gly Ile Arg Thr Arg Glu
245 250 255
Ala Phe Leu Arg Asp Leu Pro Arg Leu Leu Ala Ala Arg
260 265
<210> 500
<211> 269
<212> PRT
<213> RESISTANCE GENE
<400> 500
Met Lys Phe Arg His Ala Leu Ser Ser Ala Phe Val Leu Leu Gly Cys
1 5 10 15
Ile Ala Ala Ser Ala His Ala Lys Thr Ile Cys Thr Ala Ile Ala Asp
20 25 30
Ala Gly Thr Gly Lys Leu Leu Val Gln Asp Gly Asp Cys Gly Arg Arg
35 40 45
Ala Ser Pro Ala Ser Thr Phe Lys Ile Ala Ile Ser Leu Met Gly Tyr
50 55 60
Asp Ala Gly Phe Leu Arg Asn Glu His Asp Pro Val Leu Pro Tyr Arg
65 70 75 80
Asp Ser Tyr Ile Ala Trp Gly Gly Glu Ala Trp Lys Gln Pro Thr Asp
85 90 95
Pro Thr Arg Trp Leu Lys Tyr Ser Val Val Trp Tyr Ser Gln Gln Val
100 105 110
Ala His His Leu Gly Ala Gln Arg Phe Ala Gln Tyr Ala Lys Ala Phe
115 120 125
Gly Tyr Gly Asn Ala Asp Val Ser Gly Asp Pro Gly Gln Asn Asn Gly
130 135 140
Leu Asp Arg Ala Trp Ile Gly Ser Ser Leu Gln Ile Ser Pro Leu Glu
145 150 155 160
Gln Leu Glu Phe Leu Gly Lys Met Leu Asn Arg Lys Leu Pro Val Ser
165 170 175
Pro Thr Ala Val Asp Met Thr Glu Arg Ile Val Glu Ser Thr Thr Leu
180 185 190
Ala Asp Gly Thr Val Val His Gly Lys Thr Gly Val Ser Tyr Pro Leu
195 200 205
Leu Ala Asp Gly Thr Arg Asp Trp Ala Arg Gly Ser Gly Trp Phe Val
210 215 220
Gly Trp Ile Val Arg Gly Lys Gln Thr Leu Val Phe Ala Arg Leu Thr
225 230 235 240
Gln Asp Glu Arg Lys Gln Pro Val Ser Ala Gly Ile Arg Thr Arg Glu
245 250 255
Ala Phe Leu Arg Asp Leu Pro Arg Leu Leu Ala Ala Arg
260 265
<210> 501
<211> 266
<212> PRT
<213> RESISTANCE GENE
<400> 501
Met Lys Thr Phe Ala Ala Tyr Val Ile Ile Ala Cys Leu Ser Ser Thr
1 5 10 15
Ala Leu Ala Gly Ser Ile Thr Glu Asn Thr Ser Trp Asn Lys Glu Phe
20 25 30
Ser Ala Glu Ala Val Asn Gly Val Phe Val Leu Cys Lys Ser Ser Ser
35 40 45
Lys Ser Cys Ala Thr Asn Asp Leu Ala Arg Ala Ser Lys Glu Tyr Leu
50 55 60
Pro Val Ser Thr Phe Lys Ile Pro Ser Ala Ile Ile Gly Leu Glu Thr
65 70 75 80
Gly Val Ile Lys Asn Glu His Gln Val Phe Lys Trp Asp Gly Lys Pro
85 90 95
Arg Ala Met Lys Gln Trp Glu Arg Asp Leu Thr Leu Arg Gly Ala Ile
100 105 110
Gln Val Ser Ala Val Pro Val Phe Gln Gln Ile Ala Arg Glu Val Gly
115 120 125
Glu Val Arg Met Gln Lys Tyr Leu Lys Lys Phe Ser Tyr Gly Asn Gln
130 135 140
Asn Ile Ser Gly Gly Ile Asp Lys Phe Trp Leu Glu Gly Gln Leu Arg
145 150 155 160
Ile Ser Ala Val Asn Gln Val Glu Phe Leu Glu Ser Leu Tyr Leu Asn
165 170 175
Lys Leu Ser Ala Ser Lys Glu Asn Gln Leu Ile Val Lys Glu Ala Leu
180 185 190
Val Thr Glu Ala Ala Pro Glu Tyr Leu Val His Ser Lys Thr Gly Phe
195 200 205
Ser Gly Val Gly Thr Glu Ser Asn Pro Gly Val Ala Trp Trp Val Gly
210 215 220
Trp Val Glu Lys Glu Thr Glu Val Tyr Phe Phe Ala Phe Asn Met Asp
225 230 235 240
Ile Asp Asn Glu Ser Lys Leu Pro Leu Arg Lys Ser Ile Pro Thr Lys
245 250 255
Ile Met Glu Ser Glu Gly Ile Ile Gly Gly
260 265
<210> 502
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 502
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Glu Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Lys Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asp Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 503
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 503
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Ser Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Glu Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Gln Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asn Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Asn Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asn Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 504
<211> 266
<212> PRT
<213> RESISTANCE GENE
<400> 504
Met Lys Thr Phe Ala Ala Tyr Val Ile Thr Ala Cys Leu Ser Ser Thr
1 5 10 15
Ala Leu Ala Ser Ser Ile Thr Glu Asn Thr Phe Trp Asn Lys Glu Phe
20 25 30
Ser Ala Glu Ala Val Asn Gly Val Phe Val Leu Cys Lys Ser Ser Ser
35 40 45
Lys Ser Cys Ala Thr Asn Asn Leu Ala Arg Ala Ser Lys Glu Tyr Leu
50 55 60
Pro Ala Ser Thr Phe Lys Ile Pro Asn Ala Ile Ile Gly Leu Glu Thr
65 70 75 80
Gly Val Ile Lys Asn Glu His Gln Val Phe Lys Trp Asp Gly Lys Pro
85 90 95
Arg Ala Met Lys Gln Trp Glu Arg Asp Leu Ser Leu Arg Gly Ala Ile
100 105 110
Gln Val Ser Ala Val Pro Val Phe Gln Gln Ile Ala Arg Glu Val Gly
115 120 125
Glu Val Arg Met Gln Lys Tyr Leu Lys Lys Phe Ser Tyr Gly Asn Gln
130 135 140
Asn Ile Ser Gly Gly Ile Asp Lys Phe Trp Leu Glu Gly Gln Leu Arg
145 150 155 160
Ile Ser Ala Val Asn Gln Val Glu Phe Leu Glu Ser Leu Phe Leu Asn
165 170 175
Lys Leu Ser Ala Ser Lys Glu Asn Gln Leu Ile Val Lys Glu Ala Leu
180 185 190
Val Thr Glu Ala Ala Pro Glu Tyr Leu Val His Ser Lys Thr Gly Phe
195 200 205
Ser Gly Val Gly Thr Glu Ser Asn Pro Gly Val Ala Trp Trp Val Gly
210 215 220
Trp Val Glu Lys Gly Thr Glu Val Tyr Phe Phe Ala Phe Asn Met Asp
225 230 235 240
Ile Asp Asn Glu Asn Lys Leu Pro Leu Arg Lys Ser Ile Pro Thr Lys
245 250 255
Ile Met Ala Ser Glu Gly Ile Ile Gly Gly
260 265
<210> 505
<211> 267
<212> PRT
<213> RESISTANCE GENE
<400> 505
Met Lys Thr Ile Ala Ala Tyr Leu Val Leu Val Phe Phe Ala Gly Thr
1 5 10 15
Ala Leu Ser Glu Ser Ile Ser Glu Asn Leu Ala Trp Asn Lys Glu Phe
20 25 30
Ser Ser Glu Ser Val His Gly Val Phe Val Leu Cys Lys Ser Ser Ser
35 40 45
Asn Ser Cys Thr Thr Asn Asn Ala Thr Arg Ala Ser Thr Ala Tyr Ile
50 55 60
Pro Ala Ser Thr Phe Lys Ile Pro Asn Ala Leu Ile Gly Leu Glu Thr
65 70 75 80
Gly Ala Ile Lys Asp Ala Arg Gln Val Phe Lys Trp Asp Gly Lys Pro
85 90 95
Arg Ala Met Lys Gln Trp Glu Lys Asp Leu Thr Leu Arg Gly Ala Ile
100 105 110
Gln Val Ser Ala Val Pro Val Phe Gln Gln Ile Ala Arg Asp Ile Gly
115 120 125
Lys Lys Arg Met Gln Lys Tyr Leu Asn Leu Phe Ser Tyr Gly Asn Ala
130 135 140
Asn Ile Gly Gly Gly Ile Asp Lys Phe Trp Leu Glu Gly Gln Leu Arg
145 150 155 160
Ile Ser Ala Val Asn Gln Val Lys Phe Leu Glu Ser Leu Tyr Leu Asn
165 170 175
Asn Leu Pro Ala Ser Lys Ala Asn Gln Leu Ile Val Lys Glu Ala Ile
180 185 190
Val Thr Glu Ala Thr Pro Glu Tyr Ile Val His Ser Lys Thr Gly Tyr
195 200 205
Ser Gly Val Gly Thr Glu Ser Asn Pro Gly Val Ala Trp Trp Val Gly
210 215 220
Trp Val Glu Lys Gly Thr Glu Val Tyr Phe Phe Ala Phe Asn Met Asp
225 230 235 240
Ile Asp Asn Glu Ser Lys Leu Pro Ser Arg Lys Ser Ile Pro Thr Lys
245 250 255
Ile Met Ala Ser Glu Gly Ile Ile Ile Gly Gly
260 265
<210> 506
<211> 275
<212> PRT
<213> RESISTANCE GENE
<400> 506
Met Lys Lys Phe Ile Leu Pro Ile Phe Ser Ile Ser Ile Leu Val Ser
1 5 10 15
Leu Ser Ala Cys Ser Ser Ile Lys Thr Lys Ser Glu Asp Asn Phe His
20 25 30
Ile Ser Ser Gln Gln His Glu Lys Ala Ile Lys Ser Tyr Phe Asp Glu
35 40 45
Ala Gln Thr Gln Gly Val Ile Ile Ile Lys Glu Gly Lys Asn Leu Ser
50 55 60
Thr Tyr Gly Asn Ala Leu Ala Arg Ala Asn Lys Glu Tyr Val Pro Ala
65 70 75 80
Ser Thr Phe Lys Met Leu Ile Ala Leu Ile Gly Leu Glu Asn His Lys
85 90 95
Ala Thr Thr Asn Glu Ile Phe Lys Trp Asp Gly Lys Lys Arg Thr Tyr
100 105 110
Pro Met Trp Glu Lys Asp Met Thr Leu Gly Glu Ala Met Ala Leu Ser
115 120 125
Ala Val Pro Val Tyr Gln Glu Leu Ala Arg Arg Thr Gly Leu Glu Leu
130 135 140
Met Gln Lys Glu Val Lys Arg Val Asn Phe Gly Asn Thr Asn Ile Gly
145 150 155 160
Thr Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro
165 170 175
Val Gln Glu Val Asn Phe Ala Asp Asp Leu Ala His Asn Arg Leu Pro
180 185 190
Phe Lys Leu Glu Thr Gln Glu Glu Val Lys Lys Met Leu Leu Ile Lys
195 200 205
Glu Val Asn Gly Ser Lys Ile Tyr Ala Lys Ser Gly Trp Gly Met Gly
210 215 220
Val Thr Pro Gln Val Gly Trp Leu Thr Gly Trp Val Glu Gln Ala Asn
225 230 235 240
Gly Lys Lys Ile Pro Phe Ser Leu Asn Leu Glu Met Lys Glu Gly Met
245 250 255
Ser Gly Ser Ile Arg Asn Glu Ile Thr Tyr Lys Ser Leu Glu Asn Leu
260 265 270
Gly Ile Ile
275
<210> 507
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 507
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Phe Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Asp Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile His Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asn Gly Gln Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Met Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Asn Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asp Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 508
<211> 274
<212> PRT
<213> RESISTANCE GENE
<400> 508
Met Asn Ile Lys Ala Leu Leu Leu Ile Thr Ser Ala Ile Ser Ile Ser
1 5 10 15
Ala Cys Ser Pro Tyr Ile Val Thr Ala Asn Pro Asn His Ser Ala Ser
20 25 30
Lys Ser Asp Glu Lys Ala Glu Lys Ile Lys Asn Leu Phe Asn Glu Ala
35 40 45
His Thr Thr Gly Val Leu Val Ile Gln Gln Gly Gln Thr Gln Gln Ser
50 55 60
Tyr Gly Asn Asp Leu Ala Arg Ala Ser Thr Glu Tyr Val Pro Ala Ser
65 70 75 80
Thr Phe Lys Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys Ala
85 90 95
Thr Thr Thr Glu Val Phe Lys Trp Asp Gly Gln Lys Arg Leu Phe Pro
100 105 110
Glu Trp Glu Lys Asp Met Thr Leu Gly Asp Ala Ile Lys Ala Ser Ala
115 120 125
Ile Pro Val Tyr Gln Asp Leu Ala Arg Arg Ile Gly Leu Glu Leu Met
130 135 140
Ser Lys Glu Val Lys Arg Val Gly Tyr Gly Asn Ala Asp Ile Gly Thr
145 150 155 160
Gln Val Asp Asn Phe Trp Leu Val Gly Pro Leu Lys Ile Thr Pro Gln
165 170 175
Gln Glu Ala Gln Phe Ala Tyr Lys Leu Ala Asn Lys Thr Leu Pro Phe
180 185 190
Ser Gln Lys Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu
195 200 205
Lys Asn Gly Asn Lys Ile Tyr Ala Lys Ser Gly Trp Gly Trp Asp Val
210 215 220
Asp Pro Gln Val Gly Trp Leu Thr Gly Trp Val Val Gln Pro Gln Gly
225 230 235 240
Asn Ile Val Ala Phe Ser Leu Asn Leu Glu Met Lys Lys Gly Ile Pro
245 250 255
Ser Ser Val Arg Lys Glu Ile Thr Tyr Lys Ser Leu Glu Gln Leu Gly
260 265 270
Ile Leu
<210> 509
<211> 20
<212> PRT
<213> RESISTANCE GENE
<400> 509
Ala Ala Ala Tyr Glu Leu Ala Glu Asn Leu Phe Glu Ala Gly Gln Ala
1 5 10 15
Asp Gly Trp Arg
20
<210> 510
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 510
Ala Ala Glu Gly Phe Ile Pro Ala Ser Thr Phe Lys
1 5 10
<210> 511
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 511
Ala Ala Leu Gly Arg
1 5
<210> 512
<211> 15
<212> PRT
<213> RESISTANCE GENE
<400> 512
Ala Asp Gly Gln Val Val Ala Phe Ala Leu Asn Met Gln Met Lys
1 5 10 15
<210> 513
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 513
Ala Asp Ile Asn Glu Ile Phe Lys
1 5
<210> 514
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 514
Ala Asp Trp Gly Lys
1 5
<210> 515
<211> 11
<212> PRT
<213> RESISTANCE GENE
<400> 515
Ala Glu Gly Ala Ile Val Ile Ser Asp Glu Arg
1 5 10
<210> 516
<211> 10
<212> PRT
<213> RESISTANCE GENE
<400> 516
Ala Phe Ala Leu Asn Leu Asp Ile Asp Lys
1 5 10
<210> 517
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 517
Ala Phe Ala Pro Met Ser Thr Phe Lys
1 5
<210> 518
<211> 21
<212> PRT
<213> RESISTANCE GENE
<400> 518
Ala Phe Gly Tyr Gly Asn Ala Asp Val Ser Gly Asp Pro Gly Gln Asn
1 5 10 15
Asn Gly Leu Asp Arg
20
<210> 519
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 519
Ala Phe Thr Met Thr Lys
1 5
<210> 520
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 520
Ala Gly Asp Asp Ile Ala Leu Arg
1 5
<210> 521
<211> 15
<212> PRT
<213> RESISTANCE GENE
<400> 521
Ala Gly His Val Tyr Ala Phe Ala Leu Asn Ile Asp Met Pro Arg
1 5 10 15
<210> 522
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 522
Ala Gly Leu Trp Arg
1 5
<210> 523
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 523
Ala His Thr Glu Tyr Val Pro Ala Ser Thr Phe Lys
1 5 10
<210> 524
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 524
Ala Ile Ile Pro Trp Asp Gly Lys
1 5
<210> 525
<211> 10
<212> PRT
<213> RESISTANCE GENE
<400> 525
Ala Ile Ile Pro Trp Asp Gly Lys Pro Arg
1 5 10
<210> 526
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 526
Ala Ile Ser Asp Ile Thr Ile Thr Arg
1 5
<210> 527
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 527
Ala Ile Ser Gly Lys
1 5
<210> 528
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 528
Ala Leu Gly Gln Asp Arg
1 5
<210> 529
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 529
Ala Leu Pro Asp Leu Ala Lys
1 5
<210> 530
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 530
Ala Leu Gln Ala Lys
1 5
<210> 531
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 531
Ala Met Glu Thr Phe Ser Pro Ala Ser Thr Phe Lys
1 5 10
<210> 532
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 532
Ala Met Leu Phe Leu Gln Glu Arg
1 5
<210> 533
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 533
Ala Met Leu Val Phe Asp Pro Val Arg
1 5
<210> 534
<211> 16
<212> PRT
<213> RESISTANCE GENE
<400> 534
Ala Met Thr Leu Leu Glu Ser Gly Pro Gly Trp Glu Leu His Gly Lys
1 5 10 15
<210> 535
<211> 10
<212> PRT
<213> RESISTANCE GENE
<400> 535
Ala Asn Leu His Ile Thr Leu His Gly Lys
1 5 10
<210> 536
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 536
Ala Asn Gln Leu Ile Val Lys
1 5
<210> 537
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 537
Ala Asn Thr Glu Tyr Val Pro Ala Ser Thr Phe Lys
1 5 10
<210> 538
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 538
Ala Asn Val Ser Arg
1 5
<210> 539
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 539
Ala Pro Ile Gly Trp Phe Ile Gly Trp Ala Thr Arg
1 5 10
<210> 540
<211> 15
<212> PRT
<213> RESISTANCE GENE
<400> 540
Ala Pro Leu Gly Trp Phe Ile Gly Trp Ala Thr His Glu Glu Arg
1 5 10 15
<210> 541
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 541
Ala Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu Lys
1 5 10
<210> 542
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 542
Ala Gln Gly Val Ile Val Leu Trp Asn Glu Asn Lys
1 5 10
<210> 543
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 543
Ala Ser Ala Ile Ala Val Tyr Gln Asp Leu Ala Arg
1 5 10
<210> 544
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 544
Ala Ser Ala Ile Leu Val Tyr Gln Asp Leu Ala Arg
1 5 10
<210> 545
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 545
Ala Ser Ala Ile Pro Val Tyr Gln Asp Leu Ala Arg
1 5 10
<210> 546
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 546
Ala Ser Ala Ile Pro Val Tyr Gln Asp Leu Pro Arg
1 5 10
<210> 547
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 547
Ala Ser Ala Ile Gln Val Tyr Gln Asp Leu Ala Arg
1 5 10
<210> 548
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 548
Ala Ser Ala Ile Ser Val Tyr Gln Asp Leu Ala Arg
1 5 10
<210> 549
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 549
Ala Ser Ala Leu Pro Val Tyr Gln Asp Leu Ala Arg
1 5 10
<210> 550
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 550
Ala Ser Ala Met Pro Val Tyr Gln Asp Leu Ala Arg
1 5 10
<210> 551
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 551
Ala Ser Ala Val Pro Val Tyr Gln Asp Leu Ala Arg
1 5 10
<210> 552
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 552
Ala Ser Ile Glu Tyr Val Pro Ala Ser Thr Phe Lys
1 5 10
<210> 553
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 553
Ala Ser Asn Val Pro Val Tyr Gln Glu Leu Ala Arg
1 5 10
<210> 554
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 554
Ala Ser Pro Ala Ser Thr Phe Lys
1 5
<210> 555
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 555
Ala Ser Thr Ala Tyr Ile Pro Ala Ser Thr Phe Lys
1 5 10
<210> 556
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 556
Ala Ser Thr Glu Tyr Val Pro Ala Ser Thr Phe Lys
1 5 10
<210> 557
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 557
Ala Ser Thr Thr Glu Val Phe Lys
1 5
<210> 558
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 558
Ala Thr Ser Thr Glu Ile Phe Lys
1 5
<210> 559
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 559
Ala Thr Thr Asn Glu Ile Phe Lys
1 5
<210> 560
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 560
Ala Thr Thr Thr Ala Val Phe Lys
1 5
<210> 561
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 561
Ala Thr Thr Thr Glu Ile Phe Lys
1 5
<210> 562
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 562
Ala Thr Thr Thr Glu Val Phe Lys
1 5
<210> 563
<211> 19
<212> PRT
<213> RESISTANCE GENE
<400> 563
Ala Val Ser Asp Ile Thr Ile Leu Glu Gln Thr Asp Asn Tyr Thr Leu
1 5 10 15
His Gly Lys
<210> 564
<211> 19
<212> PRT
<213> RESISTANCE GENE
<400> 564
Ala Val Ser Asp Ile Thr Ile Leu Glu Gln Thr Tyr Asn Tyr Thr Leu
1 5 10 15
His Gly Lys
<210> 565
<211> 16
<212> PRT
<213> RESISTANCE GENE
<400> 565
Ala Val Val Pro His Phe Glu Ala Gly Asp Trp Asp Val Gln Gly Lys
1 5 10 15
<210> 566
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 566
Ala Trp Glu His Asp Met Ser Leu Arg
1 5
<210> 567
<211> 20
<212> PRT
<213> RESISTANCE GENE
<400> 567
Ala Trp Ile Gly Ser Ser Leu Gln Ile Ser Pro Leu Glu Gln Leu Glu
1 5 10 15
Phe Leu Gly Lys
20
<210> 568
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 568
Cys Ala Ala Gln Met Ala Pro Asp Ser Thr Phe Lys
1 5 10
<210> 569
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 569
Cys Ala Thr Gln Met Ala Pro Asp Ser Thr Phe Lys
1 5 10
<210> 570
<211> 21
<212> PRT
<213> RESISTANCE GENE
<400> 570
Cys Thr Ile Ile Ala Asp Ala Ile Thr Gly Asn Thr Leu Tyr Glu Thr
1 5 10 15
Gly Glu Cys Ala Arg
20
<210> 571
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 571
Asp Ala Phe Leu Lys
1 5
<210> 572
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 572
Asp Asp Phe Ile Leu His Gly Lys
1 5
<210> 573
<211> 11
<212> PRT
<213> RESISTANCE GENE
<400> 573
Asp Asp Gln Glu Val Leu Pro Tyr Gly Gly Lys
1 5 10
<210> 574
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 574
Asp Asp Val Leu Lys
1 5
<210> 575
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 575
Asp Glu Phe His Val Phe Arg
1 5
<210> 576
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 576
Asp Glu Phe Gln Ile Phe Arg
1 5
<210> 577
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 577
Asp Glu Phe Gln Val Phe Arg
1 5
<210> 578
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 578
Asp Glu Leu Val Arg
1 5
<210> 579
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 579
Asp Glu Thr Ser Arg
1 5
<210> 580
<211> 13
<212> PRT
<213> RESISTANCE GENE
<400> 580
Asp Phe Asp Tyr Gly Asn Gln Asp Phe Ser Gly Asp Lys
1 5 10
<210> 581
<211> 21
<212> PRT
<213> RESISTANCE GENE
<400> 581
Asp Phe Thr Leu Gly Glu Ala Met Gln Ala Ser Thr Val Pro Val Tyr
1 5 10 15
Gln Glu Leu Ala Arg
20
<210> 582
<211> 21
<212> PRT
<213> RESISTANCE GENE
<400> 582
Asp Gly Asn Ile Thr Ser Val Ala Ile Asn Ile Asp Met Leu Ser Glu
1 5 10 15
Ala Asp Ala Pro Lys
20
<210> 583
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 583
Asp His Asp Leu Ile Thr Ala Met Lys
1 5
<210> 584
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 584
Asp Ile Ala Ala Trp Asn Arg
1 5
<210> 585
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 585
Asp Ile Gly Glu Asp Lys
1 5
<210> 586
<211> 13
<212> PRT
<213> RESISTANCE GENE
<400> 586
Asp Ile Leu Tyr Ile Gln Glu Leu Ala Gly Gly Trp Lys
1 5 10
<210> 587
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 587
Asp Ile Thr Ile Leu Glu Lys
1 5
<210> 588
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 588
Asp Leu Leu Ser Ala Lys
1 5
<210> 589
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 589
Asp Leu Met Ile Thr Glu Ala Gly Arg
1 5
<210> 590
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 590
Asp Leu Met Ile Val Glu Ala Gly Arg
1 5
<210> 591
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 591
Asp Leu Met Ile Val Glu Ala Lys
1 5
<210> 592
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 592
Asp Leu Pro Leu Arg
1 5
<210> 593
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 593
Asp Leu Ser Gly Asn Pro Gly Lys
1 5
<210> 594
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 594
Asp Leu Ser Leu Arg
1 5
<210> 595
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 595
Asp Leu Thr Leu Arg
1 5
<210> 596
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 596
Asp Met Thr Leu Gly Asp Ala Ile Lys
1 5
<210> 597
<211> 21
<212> PRT
<213> RESISTANCE GENE
<400> 597
Asp Met Thr Leu Gly Asp Ala Met Ala Leu Ser Ala Val Pro Val Tyr
1 5 10 15
Gln Glu Leu Ala Arg
20
<210> 598
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 598
Asp Met Thr Leu Gly Asp Ala Met Lys
1 5
<210> 599
<211> 21
<212> PRT
<213> RESISTANCE GENE
<400> 599
Asp Met Thr Leu Gly Glu Ala Met Ala Leu Ser Ala Val Pro Val Tyr
1 5 10 15
Gln Asp Leu Ala Arg
20
<210> 600
<211> 21
<212> PRT
<213> RESISTANCE GENE
<400> 600
Asp Met Thr Leu Gly Glu Ala Met Ala Leu Ser Ala Val Pro Val Tyr
1 5 10 15
Gln Glu Leu Ala Arg
20
<210> 601
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 601
Asp Met Thr Leu Gly Glu Ala Met Lys
1 5
<210> 602
<211> 21
<212> PRT
<213> RESISTANCE GENE
<400> 602
Asp Met Thr Leu Gly Gln Ala Met Gln Ala Ser Ala Val Pro Val Tyr
1 5 10 15
Gln Glu Leu Ala Arg
20
<210> 603
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 603
Asp Asn Asn Gly Lys
1 5
<210> 604
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 604
Asp Gln Asp Leu Arg
1 5
<210> 605
<211> 13
<212> PRT
<213> RESISTANCE GENE
<400> 605
Asp Gln Gln Ile Gly Trp Phe Val Gly Trp Ala Ser Lys
1 5 10
<210> 606
<211> 16
<212> PRT
<213> RESISTANCE GENE
<400> 606
Asp Gln Gln Ile Gly Trp Phe Val Gly Trp Ala Ser Lys Pro Gly Lys
1 5 10 15
<210> 607
<211> 13
<212> PRT
<213> RESISTANCE GENE
<400> 607
Asp Gln Gln Val Gln Val Tyr Gly Asn Asp Leu Asn Arg
1 5 10
<210> 608
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 608
Asp Gln Ser Phe Arg
1 5
<210> 609
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 609
Asp Gln Thr Leu Glu Ser Ala Phe Lys
1 5
<210> 610
<211> 18
<212> PRT
<213> RESISTANCE GENE
<400> 610
Asp Ser Cys Val Trp Tyr Ser Gln Val Leu Thr Gln Gln Leu Gly Met
1 5 10 15
Thr Arg
<210> 611
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 611
Asp Ser Ile Val Trp Tyr Ser Gln Glu Leu Thr Arg
1 5 10
<210> 612
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 612
Asp Ser Ile Val Trp Tyr Ser Gln Gln Leu Thr Arg
1 5 10
<210> 613
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 613
Asp Ser Asn Leu Arg
1 5
<210> 614
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 614
Asp Ser Tyr Ile Ala Trp Gly Gly Glu Ala Trp Lys
1 5 10
<210> 615
<211> 10
<212> PRT
<213> RESISTANCE GENE
<400> 615
Asp Thr Leu Asn Pro Glu Trp Pro Tyr Lys
1 5 10
<210> 616
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 616
Asp Val Asp Glu Val Phe Tyr Lys
1 5
<210> 617
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 617
Asp Val Ser Gly Asp Pro Gly Lys
1 5
<210> 618
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 618
Asp Trp Ile Leu Arg
1 5
<210> 619
<211> 10
<212> PRT
<213> RESISTANCE GENE
<400> 619
Asp Trp Pro Ala Met Ala Gly Ala Trp Arg
1 5 10
<210> 620
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 620
Glu Ala Phe Leu Arg
1 5
<210> 621
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 621
Glu Ala Ile Ala Arg
1 5
<210> 622
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 622
Glu Ala Ile Val Arg
1 5
<210> 623
<211> 16
<212> PRT
<213> RESISTANCE GENE
<400> 623
Glu Ala Ile Val Thr Glu Ala Thr Pro Glu Tyr Ile Val His Ser Lys
1 5 10 15
<210> 624
<211> 16
<212> PRT
<213> RESISTANCE GENE
<400> 624
Glu Ala Leu Val Thr Glu Ala Ala Pro Glu Tyr Leu Val His Ser Lys
1 5 10 15
<210> 625
<211> 15
<212> PRT
<213> RESISTANCE GENE
<400> 625
Glu Ala Leu Val Thr Glu Ala Pro Glu Tyr Leu Val His Ser Lys
1 5 10 15
<210> 626
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 626
Glu Glu Ile Val Arg
1 5
<210> 627
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 627
Glu Glu Val Leu Ala Ala Leu Pro Ala Gln Leu Lys
1 5 10
<210> 628
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 628
Glu Phe Asn Gly Ser Lys
1 5
<210> 629
<211> 15
<212> PRT
<213> RESISTANCE GENE
<400> 629
Glu Phe Ser Ala Glu Ala Val Asn Gly Val Phe Val Leu Cys Lys
1 5 10 15
<210> 630
<211> 15
<212> PRT
<213> RESISTANCE GENE
<400> 630
Glu Phe Ser Ser Glu Ser Val His Gly Val Phe Val Leu Cys Lys
1 5 10 15
<210> 631
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 631
Glu Gly Asp Met Ala Lys
1 5
<210> 632
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 632
Glu Gly Met Ser Gly Ser Ile Arg
1 5
<210> 633
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 633
Glu Gly Met Thr Gly Ser Ile Arg
1 5
<210> 634
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 634
Glu Gly Ser Cys Asp Lys
1 5
<210> 635
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 635
Glu Ile Ala Val Trp Asn Arg
1 5
<210> 636
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 636
Glu Ile Ala Tyr Lys
1 5
<210> 637
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 637
Glu Ile Phe Glu Arg
1 5
<210> 638
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 638
Glu Ile Phe Tyr His Tyr Arg
1 5
<210> 639
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 639
Glu Ile Gly Asp Asp Lys
1 5
<210> 640
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 640
Glu Ile Gly Asp Gly Lys
1 5
<210> 641
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 641
Glu Ile Gly Glu Asp Lys
1 5
<210> 642
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 642
Glu Ile Gly Glu Asp Asn Ala Arg
1 5
<210> 643
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 643
Glu Ile Gly Glu Asn Lys
1 5
<210> 644
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 644
Glu Ile Gly Pro Lys
1 5
<210> 645
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 645
Glu Ile Gly Ser Glu Ile Asp Lys
1 5
<210> 646
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 646
Glu Ile Thr Tyr Lys
1 5
<210> 647
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 647
Glu Ile Thr Tyr Arg
1 5
<210> 648
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 648
Glu Met Ile Tyr Leu Lys
1 5
<210> 649
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 649
Glu Met Leu Tyr Val Glu Arg
1 5
<210> 650
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 650
Glu Met Thr Tyr Lys
1 5
<210> 651
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 651
Glu Asn Ile Glu Lys
1 5
<210> 652
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 652
Glu Asn Gln Leu Ile Val Lys
1 5
<210> 653
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 653
Glu Gln Ala Ile Leu Leu Phe Arg
1 5
<210> 654
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 654
Glu Gln Ile Gln Phe Leu Leu Arg
1 5
<210> 655
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 655
Glu Gln Leu Ala Phe Asp Pro Gln Val Gln Gln Gln Val Lys
1 5 10
<210> 656
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 656
Glu Gln Val Asp Phe Val Gln Arg
1 5
<210> 657
<211> 18
<212> PRT
<213> RESISTANCE GENE
<400> 657
Glu Thr Glu Val Tyr Phe Phe Ala Phe Asn Met Asp Ile Asp Asn Glu
1 5 10 15
Ser Lys
<210> 658
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 658
Glu Thr Thr Thr Pro Arg
1 5
<210> 659
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 659
Glu Val Gly Glu Ile Arg
1 5
<210> 660
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 660
Glu Val Gly Glu Val Arg
1 5
<210> 661
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 661
Glu Val Asn Gly Ser Lys
1 5
<210> 662
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 662
Glu Trp Gln Glu Asn Lys
1 5
<210> 663
<211> 10
<212> PRT
<213> RESISTANCE GENE
<400> 663
Glu Tyr Glu Leu Tyr Leu Asn Val Trp Lys
1 5 10
<210> 664
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 664
Glu Tyr Leu Pro Ala Ser Thr Phe Lys
1 5
<210> 665
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 665
Glu Tyr Leu Pro Val Ser Thr Phe Lys
1 5
<210> 666
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 666
Glu Tyr Asn Thr Ser Gly Thr Phe Val Phe Tyr Asp Gly Lys
1 5 10
<210> 667
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 667
Glu Tyr Val Pro Ala Ser Thr Phe Lys
1 5
<210> 668
<211> 21
<212> PRT
<213> RESISTANCE GENE
<400> 668
Phe Ala Ala Tyr Val Ala Gly Phe Gly Tyr Gly Asn Gly Asp Ile Ser
1 5 10 15
Gly Glu Pro Gly Lys
20
<210> 669
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 669
Phe Ala Pro Glu Ser Thr Phe Lys
1 5
<210> 670
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 670
Phe Ala Gln Tyr Ala Lys
1 5
<210> 671
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 671
Phe Asp Tyr Gly Asn Lys
1 5
<210> 672
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 672
Phe Asp Tyr Gly Asn Arg
1 5
<210> 673
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 673
Phe Glu Asp Leu Tyr Lys
1 5
<210> 674
<211> 11
<212> PRT
<213> RESISTANCE GENE
<400> 674
Phe Glu Asp Thr Phe His Ile Ser Asn Gln Lys
1 5 10
<210> 675
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 675
Phe Glu Asp Thr Phe His Thr Ser Asn Gln Gln His Glu Lys
1 5 10
<210> 676
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 676
Phe Glu Tyr Gly Asn Gln Asp Val Ser Gly Asp Ser Gly Lys
1 5 10
<210> 677
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 677
Phe Phe Ser Asp Phe Gln Ala Lys
1 5
<210> 678
<211> 17
<212> PRT
<213> RESISTANCE GENE
<400> 678
Phe Phe Ser Asp Leu Gln Ala Glu Gly Ala Ile Val Ile Ala Asp Glu
1 5 10 15
Arg
<210> 679
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 679
Phe Phe Ser Asp Leu Arg
1 5
<210> 680
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 680
Phe Phe Ser Glu Phe Gln Ala Lys
1 5
<210> 681
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 681
Phe Gly Leu Glu Gly Gln Leu Arg
1 5
<210> 682
<211> 21
<212> PRT
<213> RESISTANCE GENE
<400> 682
Phe Ile Leu Pro Ile Phe Ser Ile Ser Ile Leu Val Ser Leu Ser Ala
1 5 10 15
Cys Ser Ser Ile Lys
20
<210> 683
<211> 20
<212> PRT
<213> RESISTANCE GENE
<400> 683
Phe Leu Ala Leu Leu Phe Ser Ala Val Val Leu Val Ser Leu Gly His
1 5 10 15
Ala Gln Asp Lys
20
<210> 684
<211> 20
<212> PRT
<213> RESISTANCE GENE
<400> 684
Phe Leu Ala Leu Leu Phe Ser Ala Val Val Leu Val Ser Leu Gly His
1 5 10 15
Ala Gln Glu Lys
20
<210> 685
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 685
Phe Leu Glu Ser Leu Tyr Leu Asn Asn Leu Pro Ala Ser Lys
1 5 10
<210> 686
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 686
Phe Leu Leu Glu Gly Gln Leu Arg
1 5
<210> 687
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 687
Phe Gln Gln Tyr Val Asp Arg
1 5
<210> 688
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 688
Phe Ser Asp Tyr Val Gln Arg
1 5
<210> 689
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 689
Phe Ser Thr Ala Ser Thr Phe Lys
1 5
<210> 690
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 690
Phe Ser Trp Asp Gly Lys
1 5
<210> 691
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 691
Phe Ser Tyr Gly Asn Gln Asn Ile Ser Gly Gly Ile Asp Lys
1 5 10
<210> 692
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 692
Phe Ser Tyr Gly Asn Gln Asn Ile Ser Gly Gly Thr Asp Lys
1 5 10
<210> 693
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 693
Phe Ser Tyr Gly Ser Gln Asn Ile Ser Gly Gly Ile Asp Lys
1 5 10
<210> 694
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 694
Phe Thr Glu Tyr Val Lys
1 5
<210> 695
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 695
Phe Val Ala His Lys
1 5
<210> 696
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 696
Phe Val Pro Ala Ser Thr Tyr Lys
1 5
<210> 697
<211> 13
<212> PRT
<213> RESISTANCE GENE
<400> 697
Phe Val Tyr Asp Leu Ala Gln Gly Gln Leu Pro Phe Lys
1 5 10
<210> 698
<211> 21
<212> PRT
<213> RESISTANCE GENE
<400> 698
Phe Val Tyr Asp Leu Ala Gln Gly Gln Leu Pro Phe Lys Pro Glu Val
1 5 10 15
Gln Gln Gln Val Lys
20
<210> 699
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 699
Phe Trp Leu Glu Asp Gln Leu Arg
1 5
<210> 700
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 700
Phe Trp Leu Glu Gly Pro Leu Lys
1 5
<210> 701
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 701
Phe Trp Leu Glu Gly Gln Leu Arg
1 5
<210> 702
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 702
Phe Tyr Pro Ala Ser Ser Phe Lys
1 5
<210> 703
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 703
Phe Tyr Pro Ala Ser Thr Phe Lys
1 5
<210> 704
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 704
Gly Ala Cys Asp Lys
1 5
<210> 705
<211> 18
<212> PRT
<213> RESISTANCE GENE
<400> 705
Gly Ala Glu Val Tyr Phe Phe Ala Phe Asn Met Asp Ile Asp Asn Glu
1 5 10 15
Asn Lys
<210> 706
<211> 16
<212> PRT
<213> RESISTANCE GENE
<400> 706
Gly Ala Ile Gln Val Ser Ala Val Pro Val Phe Gln Gln Ile Ala Arg
1 5 10 15
<210> 707
<211> 16
<212> PRT
<213> RESISTANCE GENE
<400> 707
Gly Ala Ile Gln Val Ser Ala Val Pro Val Phe Gln Gln Ile Thr Arg
1 5 10 15
<210> 708
<211> 21
<212> PRT
<213> RESISTANCE GENE
<400> 708
Gly Asp Tyr Trp Ile Asp Gly Asn Leu Glu Ile Ser Ala His Glu Gln
1 5 10 15
Ile Ser Phe Leu Arg
20
<210> 709
<211> 10
<212> PRT
<213> RESISTANCE GENE
<400> 709
Gly Asp Tyr Trp Ile Asp Gly Asn Leu Lys
1 5 10
<210> 710
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 710
Gly Glu Leu Pro Val Ser Glu Asp Ala Leu Glu Met Thr Lys
1 5 10
<210> 711
<211> 10
<212> PRT
<213> RESISTANCE GENE
<400> 711
Gly Glu Gln Pro Ala Gly Pro Ala Ala Arg
1 5 10
<210> 712
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 712
Gly Phe Ala Gly His Asn Gln Asp Gln Asp Leu Arg
1 5 10
<210> 713
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 713
Gly Ile Pro Ser Ser Val Arg
1 5
<210> 714
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 714
Gly Ile Ser Ser Ser Val Arg
1 5
<210> 715
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 715
Gly Leu Asn Gly Thr Phe Val Val Tyr Asp Leu Lys
1 5 10
<210> 716
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 716
Gly Met Glu Ile Trp Asn Ser Asn His Thr Pro Lys
1 5 10
<210> 717
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 717
Gly Asn Gln Thr Leu Val Phe Ala Arg
1 5
<210> 718
<211> 21
<212> PRT
<213> RESISTANCE GENE
<400> 718
Gly Asn Tyr Trp Ile Asp Gly Asn Leu Glu Ile Ser Ala His Glu Gln
1 5 10 15
Ile Ser Phe Leu Arg
20
<210> 719
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 719
Gly Pro Leu Glu Ile Ser Ala Phe Glu Glu Ala Arg
1 5 10
<210> 720
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 720
Gly Pro Leu Thr Ile Thr Pro Ile Gln Glu Val Lys
1 5 10
<210> 721
<211> 11
<212> PRT
<213> RESISTANCE GENE
<400> 721
Gly Ser Gly Trp Phe Val Gly Trp Ile Val Arg
1 5 10
<210> 722
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 722
Gly Ser Leu Leu Leu Trp Asp Gln Lys
1 5
<210> 723
<211> 18
<212> PRT
<213> RESISTANCE GENE
<400> 723
Gly Thr Glu Val Tyr Phe Phe Ala Phe Asn Met Asp Ile Asp Asn Glu
1 5 10 15
Asn Lys
<210> 724
<211> 18
<212> PRT
<213> RESISTANCE GENE
<400> 724
Gly Thr Glu Val Tyr Phe Phe Ala Phe Asn Met Asp Ile Asp Asn Glu
1 5 10 15
Ser Lys
<210> 725
<211> 10
<212> PRT
<213> RESISTANCE GENE
<400> 725
Gly Thr Phe Val Leu Tyr Asp Val Gln Arg
1 5 10
<210> 726
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 726
Gly Thr Ile Val Val Ala Asp Glu Arg
1 5
<210> 727
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 727
Gly Thr Ile Val Val Leu Asp Ala Arg
1 5
<210> 728
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 728
Gly Thr Ile Val Val Val Asp Glu Arg
1 5
<210> 729
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 729
Gly Thr Leu Pro Phe Ser Ala Arg
1 5
<210> 730
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 730
Gly Thr Pro Ser Ser Val Arg
1 5
<210> 731
<211> 20
<212> PRT
<213> RESISTANCE GENE
<400> 731
His Ala Leu Ser Ser Ala Phe Val Leu Leu Gly Cys Ile Ala Ala Ser
1 5 10 15
Ala His Ala Lys
20
<210> 732
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 732
His Ile Ala Asp Ser Lys
1 5
<210> 733
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 733
His Asn Gly Leu Thr His Ala Trp Leu Ala Ser Ser Leu Lys
1 5 10
<210> 734
<211> 18
<212> PRT
<213> RESISTANCE GENE
<400> 734
His Asn Gly Leu Thr Gln Ser Trp Leu Met Ser Ser Leu Thr Ile Ser
1 5 10 15
Pro Lys
<210> 735
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 735
His Asn Gly Thr Asp Gly Ala Trp Ile Ile Ser Ser Leu Arg
1 5 10
<210> 736
<211> 10
<212> PRT
<213> RESISTANCE GENE
<400> 736
His Thr Leu Ser Val Phe Asp Gln Glu Arg
1 5 10
<210> 737
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 737
His Val Thr Phe Ala Ser Phe Arg
1 5
<210> 738
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 738
Ile Ala Ile Ser Leu Met Gly Tyr Asp Ala Gly Phe Leu Arg
1 5 10
<210> 739
<211> 16
<212> PRT
<213> RESISTANCE GENE
<400> 739
Ile Ala Leu Ser Leu Met Ala Phe Asp Ala Glu Ile Ile Asp Gln Lys
1 5 10 15
<210> 740
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 740
Ile Ala Leu Ser Leu Met Gly Phe Asp Ser Gly Ile Leu Lys
1 5 10
<210> 741
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 741
Ile Ala Asn Ala Leu Ile Gly Leu Glu Asn His Lys
1 5 10
<210> 742
<211> 11
<212> PRT
<213> RESISTANCE GENE
<400> 742
Ile Ala Trp Ile Val Gly Phe Val Tyr Leu Lys
1 5 10
<210> 743
<211> 11
<212> PRT
<213> RESISTANCE GENE
<400> 743
Ile Asp Thr Phe Trp Leu Asp Asn Ser Leu Lys
1 5 10
<210> 744
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 744
Ile Asp Tyr Tyr Asn Leu Asp Arg
1 5
<210> 745
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 745
Ile Phe Asn Ala Leu Ile Ala Leu Asp Ser Gly Val Ile Lys
1 5 10
<210> 746
<211> 17
<212> PRT
<213> RESISTANCE GENE
<400> 746
Ile Phe Asn Ser Leu Leu Ala Leu Asp Ser Gly Ala Leu Asp Asn Glu
1 5 10 15
Arg
<210> 747
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 747
Ile Phe Asn Thr Leu Ile Gly Leu Glu Asn Gly Ile Val Lys
1 5 10
<210> 748
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 748
Ile Gly Leu Asp Leu Met Gln Lys
1 5
<210> 749
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 749
Ile Gly Leu Glu Lys
1 5
<210> 750
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 750
Ile Gly Leu Glu Leu Met Gln Gln Glu Val Gln Arg
1 5 10
<210> 751
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 751
Ile Gly Leu Glu Leu Met Ser Lys
1 5
<210> 752
<211> 11
<212> PRT
<213> RESISTANCE GENE
<400> 752
Ile Gly Leu Glu Leu Met Ser Asn Glu Val Lys
1 5 10
<210> 753
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 753
Ile Gly Leu Glu Arg
1 5
<210> 754
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 754
Ile Gly Leu Asn Lys
1 5
<210> 755
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 755
Ile Gly Leu Asn Leu Met Gln Lys
1 5
<210> 756
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 756
Ile Gly Pro Ser Leu Met Gln Ser Glu Leu Gln Arg
1 5 10
<210> 757
<211> 18
<212> PRT
<213> RESISTANCE GENE
<400> 757
Ile Gly Tyr Gly Asn Met Gln Ile Gly Thr Glu Val Asp Gln Phe Trp
1 5 10 15
Leu Lys
<210> 758
<211> 18
<212> PRT
<213> RESISTANCE GENE
<400> 758
Ile Gly Tyr Gly Asn Met Gln Met Gly Thr Glu Val Asp Gln Phe Trp
1 5 10 15
Leu Lys
<210> 759
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 759
Ile Ile Asn His Asn Leu Pro Val Lys
1 5
<210> 760
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 760
Ile Ile Asn His Asn Leu Pro Val Arg
1 5
<210> 761
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 761
Ile Leu Phe Gln Gln Gly Thr Gln Gln Ala Cys Ala Glu Arg
1 5 10
<210> 762
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 762
Ile Leu Asn Asn Trp Phe Lys
1 5
<210> 763
<211> 11
<212> PRT
<213> RESISTANCE GENE
<400> 763
Ile Leu Asn Thr Leu Ile Ser Leu Glu Glu Lys
1 5 10
<210> 764
<211> 21
<212> PRT
<213> RESISTANCE GENE
<400> 764
Ile Leu Ser Leu Val Cys Leu Ser Ile Ser Ile Gly Ala Cys Ala Glu
1 5 10 15
His Ser Met Ser Arg
20
<210> 765
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 765
Ile Asn Glu Ser Arg
1 5
<210> 766
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 766
Ile Asn Ile Val Lys
1 5
<210> 767
<211> 10
<212> PRT
<213> RESISTANCE GENE
<400> 767
Ile Asn Leu Tyr Gly Asn Ala Leu Ser Arg
1 5 10
<210> 768
<211> 10
<212> PRT
<213> RESISTANCE GENE
<400> 768
Ile Pro Phe Ser Leu Asn Leu Glu Met Lys
1 5 10
<210> 769
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 769
Ile Pro His Thr Leu Phe Ala Leu Asp Ala Asp Ala Val Arg
1 5 10
<210> 770
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 770
Ile Pro His Thr Leu Phe Ala Leu Asp Ala Gly Ala Ala Arg
1 5 10
<210> 771
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 771
Ile Pro His Thr Leu Phe Ala Leu Asp Ala Gly Ala Val Arg
1 5 10
<210> 772
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 772
Ile Pro Leu Gly Lys
1 5
<210> 773
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 773
Ile Pro Asn Ala Ile Ile Gly Leu Glu Thr Gly Val Ile Lys
1 5 10
<210> 774
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 774
Ile Pro Asn Ala Leu Ile Gly Leu Glu Thr Gly Ala Ile Lys
1 5 10
<210> 775
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 775
Ile Pro Asn Ser Leu Ile Ala Phe Asp Thr Gly Ala Val Arg
1 5 10
<210> 776
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 776
Ile Pro Ser Ala Ile Ile Gly Leu Glu Thr Gly Val Ile Lys
1 5 10
<210> 777
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 777
Ile Ser Ala Phe Asn Gln Val Lys
1 5
<210> 778
<211> 11
<212> PRT
<213> RESISTANCE GENE
<400> 778
Ile Ser Ala His Glu Gln Ile Leu Phe Leu Arg
1 5 10
<210> 779
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 779
Ile Ser Ala Met Glu Gln Thr Arg
1 5
<210> 780
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 780
Ile Ser Ala Met Glu Gln Val Lys
1 5
<210> 781
<211> 11
<212> PRT
<213> RESISTANCE GENE
<400> 781
Ile Ser Ala Thr Glu Gln Val Ala Phe Leu Arg
1 5 10
<210> 782
<211> 11
<212> PRT
<213> RESISTANCE GENE
<400> 782
Ile Ser Ala Thr Gln Gln Ile Ala Phe Leu Arg
1 5 10
<210> 783
<211> 17
<212> PRT
<213> RESISTANCE GENE
<400> 783
Ile Ser Ala Val Asn Gln Val Glu Phe Leu Glu Ser Leu Phe Leu Asn
1 5 10 15
Lys
<210> 784
<211> 17
<212> PRT
<213> RESISTANCE GENE
<400> 784
Ile Ser Ala Val Asn Gln Val Glu Phe Leu Glu Ser Leu Tyr Leu Asn
1 5 10 15
Lys
<210> 785
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 785
Ile Ser Ala Val Asn Gln Val Lys
1 5
<210> 786
<211> 11
<212> PRT
<213> RESISTANCE GENE
<400> 786
Ile Ser Pro Glu Glu Gln Ile Gln Phe Leu Arg
1 5 10
<210> 787
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 787
Ile Ser Pro Glu Glu Gln Val Arg
1 5
<210> 788
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 788
Ile Ser Pro Glu Gly Gln Val Arg
1 5
<210> 789
<211> 11
<212> PRT
<213> RESISTANCE GENE
<400> 789
Ile Ser Pro Leu Glu Gln Leu Ala Phe Leu Arg
1 5 10
<210> 790
<211> 11
<212> PRT
<213> RESISTANCE GENE
<400> 790
Ile Thr Ala Phe Gln Gln Val Asp Phe Leu Arg
1 5 10
<210> 791
<211> 16
<212> PRT
<213> RESISTANCE GENE
<400> 791
Ile Thr Leu Phe Leu Leu Phe Leu Asn Leu Val Phe Gly Gln Asp Lys
1 5 10 15
<210> 792
<211> 17
<212> PRT
<213> RESISTANCE GENE
<400> 792
Ile Thr Pro Ile Gln Glu Val Asn Phe Ala Asp Asp Phe Ala Asn Asn
1 5 10 15
Arg
<210> 793
<211> 17
<212> PRT
<213> RESISTANCE GENE
<400> 793
Ile Thr Pro Ile Gln Glu Val Asn Phe Ala Asp Asp Leu Ala Asn Asn
1 5 10 15
Arg
<210> 794
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 794
Ile Thr Pro Gln Gln Glu Ala Gln Phe Ala Tyr Lys
1 5 10
<210> 795
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 795
Ile Thr Pro Gln Gln Glu Ala Gln Phe Thr Tyr Lys
1 5 10
<210> 796
<211> 17
<212> PRT
<213> RESISTANCE GENE
<400> 796
Ile Thr Pro Val Gln Glu Val Asn Phe Ala Asp Asp Leu Ala His Asn
1 5 10 15
Arg
<210> 797
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 797
Ile Val Ala Phe Ala Leu Lys
1 5
<210> 798
<211> 11
<212> PRT
<213> RESISTANCE GENE
<400> 798
Ile Val Ala Phe Ala Leu Asn Met Glu Met Arg
1 5 10
<210> 799
<211> 16
<212> PRT
<213> RESISTANCE GENE
<400> 799
Ile Val Glu Ser Thr Thr Leu Ala Asp Gly Thr Val Val His Gly Lys
1 5 10 15
<210> 800
<211> 11
<212> PRT
<213> RESISTANCE GENE
<400> 800
Ile Tyr Asn Ser Leu Ile Gly Leu Asn Glu Lys
1 5 10
<210> 801
<211> 13
<212> PRT
<213> RESISTANCE GENE
<400> 801
Lys Pro Asp Ile Gly Trp Trp Val Gly Trp Ile Glu Arg
1 5 10
<210> 802
<211> 10
<212> PRT
<213> RESISTANCE GENE
<400> 802
Leu Ala Cys Ala Thr Asn Asn Leu Ala Arg
1 5 10
<210> 803
<211> 17
<212> PRT
<213> RESISTANCE GENE
<400> 803
Leu Ala Gln Gly Glu Leu Pro Phe Pro Ala Pro Val Gln Ser Thr Val
1 5 10 15
Arg
<210> 804
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 804
Leu Ala Gln Asn Glu Leu Pro Tyr Pro Ile Glu Ile Gln Lys
1 5 10
<210> 805
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 805
Leu Ala Gln Asn Glu Leu Gln Tyr Pro Ile Glu Ile Gln Lys
1 5 10
<210> 806
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 806
Leu Asp Phe Gly Asn Lys
1 5
<210> 807
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 807
Leu Asp Gly Ser Leu Asn Arg
1 5
<210> 808
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 808
Leu Glu Ile Gly Lys
1 5
<210> 809
<211> 16
<212> PRT
<213> RESISTANCE GENE
<400> 809
Leu Glu Ile Leu Gln Gln Ala Leu Ala Glu Leu Gly Leu Tyr Pro Lys
1 5 10 15
<210> 810
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 810
Leu Glu Asn Gln Glu Gln Val Lys
1 5
<210> 811
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 811
Leu Glu Thr Gln Glu Glu Val Glu Lys
1 5
<210> 812
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 812
Leu Glu Thr Gln Glu Glu Val Lys
1 5
<210> 813
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 813
Leu Phe Ala Ala Glu Gly Val Lys
1 5
<210> 814
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 814
Leu Phe Glu Ser Ala Gly Val Lys
1 5
<210> 815
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 815
Leu Phe Gly Ala Ala Gly Val Lys
1 5
<210> 816
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 816
Leu Phe Pro Glu Trp Glu Lys
1 5
<210> 817
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 817
Leu Gly Glu Ser Arg
1 5
<210> 818
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 818
Leu Gly Val Asp Arg
1 5
<210> 819
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 819
Leu His Val Ser Glu Arg
1 5
<210> 820
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 820
Leu His Tyr Gly Asn Ala Lys
1 5
<210> 821
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 821
Leu Leu Asn Leu Leu Ser Gln Ser Lys
1 5
<210> 822
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 822
Leu Leu Gln Asp Glu Arg
1 5
<210> 823
<211> 10
<212> PRT
<213> RESISTANCE GENE
<400> 823
Leu Leu Val Gln Asp Gly Asp Cys Gly Arg
1 5 10
<210> 824
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 824
Leu Asn Glu Val Gly Tyr Gly Asn Arg
1 5
<210> 825
<211> 11
<212> PRT
<213> RESISTANCE GENE
<400> 825
Leu Asn Tyr Gly Asn Ala Asp Pro Ser Thr Lys
1 5 10
<210> 826
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 826
Leu Asn Tyr Gly Asn Lys
1 5
<210> 827
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 827
Leu Pro Ala Ser Lys
1 5
<210> 828
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 828
Leu Pro His Thr Leu Phe Ala Leu Asp Ala Asp Ala Val Arg
1 5 10
<210> 829
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 829
Leu Pro His Thr Leu Phe Ala Leu Asp Ala Gly Ala Val Arg
1 5 10
<210> 830
<211> 17
<212> PRT
<213> RESISTANCE GENE
<400> 830
Leu Pro Leu Ala Ile Met Gly Phe Asp Ser Gly Ile Leu Gln Ser Pro
1 5 10 15
Lys
<210> 831
<211> 20
<212> PRT
<213> RESISTANCE GENE
<400> 831
Leu Pro Leu Ala Ile Met Gly Tyr Asp Ala Asp Ile Leu Leu Asp Ala
1 5 10 15
Thr Thr Pro Arg
20
<210> 832
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 832
Leu Pro Ser Ser Leu Ile Ala Leu Glu Thr Gly Ala Val Arg
1 5 10
<210> 833
<211> 16
<212> PRT
<213> RESISTANCE GENE
<400> 833
Leu Pro Val Ser Ala Gln Thr Leu Gln Tyr Thr Ala Asn Ile Leu Lys
1 5 10 15
<210> 834
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 834
Leu Pro Val Ser Glu Arg
1 5
<210> 835
<211> 13
<212> PRT
<213> RESISTANCE GENE
<400> 835
Leu Pro Val Ser Pro Thr Ala Val Asp Met Thr Glu Arg
1 5 10
<210> 836
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 836
Leu Ser Ala Ser Lys
1 5
<210> 837
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 837
Leu Ser Ala Val Pro Ile Tyr Gln Glu Val Ala Arg
1 5 10
<210> 838
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 838
Leu Ser Ala Val Pro Val Tyr Gln Glu Leu Ala Arg
1 5 10
<210> 839
<211> 17
<212> PRT
<213> RESISTANCE GENE
<400> 839
Leu Ser Cys Thr Leu Val Ile Asp Glu Ala Ser Gly Asp Leu Leu His
1 5 10 15
Arg
<210> 840
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 840
Leu Ser Leu Gln His Gly Trp Phe Ile Gly Trp Ile Glu Lys
1 5 10
<210> 841
<211> 17
<212> PRT
<213> RESISTANCE GENE
<400> 841
Leu Ser Gln Asn Ser Leu Pro Phe Ser Gln Glu Ala Met Asn Ser Val
1 5 10 15
Lys
<210> 842
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 842
Leu Ser Val Asn Pro Lys
1 5
<210> 843
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 843
Leu Thr Gln Asp Glu Arg
1 5
<210> 844
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 844
Leu Thr Val Gly Ala Arg
1 5
<210> 845
<211> 19
<212> PRT
<213> RESISTANCE GENE
<400> 845
Leu Tyr Gly Phe Ala Leu Asn Ile Asp Met Pro Gly Gly Glu Ala Asp
1 5 10 15
Ile Gly Lys
<210> 846
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 846
Leu Tyr His Asn Glu Leu Pro Phe Arg
1 5
<210> 847
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 847
Leu Tyr His Asn Lys
1 5
<210> 848
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 848
Leu Tyr Gln Asn Asp Leu Pro Phe Arg
1 5
<210> 849
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 849
Met Asp Asp Leu Phe Lys
1 5
<210> 850
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 850
Met Glu Asp Leu His Lys
1 5
<210> 851
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 851
Met Leu Ile Ala Leu Ile Gly Leu Glu Asn His Lys
1 5 10
<210> 852
<211> 15
<212> PRT
<213> RESISTANCE GENE
<400> 852
Met Leu Leu Ile Glu Gln Gln Gly Asp Ala Ala Leu Tyr Ala Lys
1 5 10 15
<210> 853
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 853
Met Leu Leu Ile Lys
1 5
<210> 854
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 854
Met Leu Asn Ala Leu Ile Gly Leu Glu His His Lys
1 5 10
<210> 855
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 855
Met Leu Asn Ala Leu Ile Gly Leu Glu Asn His Lys
1 5 10
<210> 856
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 856
Met Leu Asn Ala Leu Ile Gly Leu Glu Asn Gln Lys
1 5 10
<210> 857
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 857
Met Leu Asn Ala Leu Ile Gly Leu Glu Tyr His Lys
1 5 10
<210> 858
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 858
Met Leu Asn Ala Leu Ile Gly Leu Gln His Gly Lys
1 5 10
<210> 859
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 859
Met Leu Asn Ala Leu Ile Ser Leu Glu His His Lys
1 5 10
<210> 860
<211> 13
<212> PRT
<213> RESISTANCE GENE
<400> 860
Met Gln Ala Tyr Val Asp Ala Phe Asp Tyr Gly Asn Arg
1 5 10
<210> 861
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 861
Met Gln Glu Gly Leu Asn Lys
1 5
<210> 862
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 862
Met Ser Pro Ala Ser Thr Tyr Lys
1 5
<210> 863
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 863
Met Thr Ala Gly Gly Lys
1 5
<210> 864
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 864
Met Val Ser Gly Lys
1 5
<210> 865
<211> 10
<212> PRT
<213> RESISTANCE GENE
<400> 865
Asn Glu His Asp Pro Val Leu Pro Tyr Arg
1 5 10
<210> 866
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 866
Asn Glu His Gln Ile Phe Lys
1 5
<210> 867
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 867
Asn Glu His Gln Val Phe Lys
1 5
<210> 868
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 868
Asn Glu Ile Thr Tyr Lys
1 5
<210> 869
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 869
Asn Glu Leu Leu Met Lys
1 5
<210> 870
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 870
Asn Glu Leu Met Met Lys
1 5
<210> 871
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 871
Asn Glu Leu Pro Phe Arg
1 5
<210> 872
<211> 15
<212> PRT
<213> RESISTANCE GENE
<400> 872
Asn Phe Ile Leu Ile Phe Ile Phe Val Ile Leu Ile Ser Cys Lys
1 5 10 15
<210> 873
<211> 15
<212> PRT
<213> RESISTANCE GENE
<400> 873
Asn Phe Ile Leu Ile Phe Ile Phe Val Ile Leu Thr Ser Cys Lys
1 5 10 15
<210> 874
<211> 11
<212> PRT
<213> RESISTANCE GENE
<400> 874
Asn Ile Ser Ser Tyr Gly Asn Asn Leu Val Arg
1 5 10
<210> 875
<211> 11
<212> PRT
<213> RESISTANCE GENE
<400> 875
Asn Ile Ser Thr Tyr Gly Asn Asn Leu Thr Arg
1 5 10
<210> 876
<211> 15
<212> PRT
<213> RESISTANCE GENE
<400> 876
Asn Leu Phe Asn Glu Val His Thr Thr Gly Val Leu Val Ile Arg
1 5 10 15
<210> 877
<211> 11
<212> PRT
<213> RESISTANCE GENE
<400> 877
Asn Leu Ser Thr Tyr Gly Asn Ala Leu Ala Arg
1 5 10
<210> 878
<211> 10
<212> PRT
<213> RESISTANCE GENE
<400> 878
Asn Met Glu Asn Leu Glu Leu Phe Gly Lys
1 5 10
<210> 879
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 879
Asn Met Leu Leu Leu Glu Glu Asn Asn Gly Tyr Lys
1 5 10
<210> 880
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 880
Asn Met Leu Leu Leu Glu Glu Ser Asn Gly Tyr Lys
1 5 10
<210> 881
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 881
Asn Met Leu Leu Leu Glu Lys
1 5
<210> 882
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 882
Asn Met Thr Leu Gly Asp Ala Met Lys
1 5
<210> 883
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 883
Asn Asn Gly Leu Thr Glu Ala Trp Leu Glu Ser Ser Leu Lys
1 5 10
<210> 884
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 884
Asn Gln Leu Pro Phe Lys
1 5
<210> 885
<211> 11
<212> PRT
<213> RESISTANCE GENE
<400> 885
Asn Gln Leu Pro Phe Gln Val Glu His Gln Arg
1 5 10
<210> 886
<211> 21
<212> PRT
<213> RESISTANCE GENE
<400> 886
Asn Ser Ala Ile Glu Asn Thr Ile Asp Asn Met Tyr Leu Gln Asp Leu
1 5 10 15
Glu Asn Ser Thr Lys
20
<210> 887
<211> 21
<212> PRT
<213> RESISTANCE GENE
<400> 887
Asn Ser Ala Ile Glu Asn Thr Ile Glu Asn Met Tyr Leu Gln Asp Leu
1 5 10 15
Asp Asn Ser Thr Lys
20
<210> 888
<211> 21
<212> PRT
<213> RESISTANCE GENE
<400> 888
Asn Ser Ala Ile Glu Asn Thr Ile Glu Asn Met Tyr Leu Gln Asp Leu
1 5 10 15
Glu Asn Ser Thr Lys
20
<210> 889
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 889
Asn Ser Ala Val Trp Val Tyr Glu Leu Phe Ala Lys
1 5 10
<210> 890
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 890
Asn Ser Gln Val Pro Ala Tyr Lys
1 5
<210> 891
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 891
Asn Ser Thr Val Trp Ile Tyr Glu Leu Phe Ala Lys
1 5 10
<210> 892
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 892
Asn Ser Thr Val Trp Val Tyr Glu Leu Phe Ala Lys
1 5 10
<210> 893
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 893
Asn Ser Thr Val Trp Val Tyr Gln Leu Phe Ala Lys
1 5 10
<210> 894
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 894
Asn Thr Ser Gly Ala Leu Val Ile Gln Thr Asp Lys
1 5 10
<210> 895
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 895
Asn Thr Ser Gly Val Leu Val Ile Gln Thr Asp Lys
1 5 10
<210> 896
<211> 13
<212> PRT
<213> RESISTANCE GENE
<400> 896
Asn Val Asp Glu Met Phe Tyr Tyr Tyr Asp Gly Ser Lys
1 5 10
<210> 897
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 897
Asn Trp Ile Leu Arg
1 5
<210> 898
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 898
Asn Trp Asn Ala Ala Met Asp Leu Arg
1 5
<210> 899
<211> 17
<212> PRT
<213> RESISTANCE GENE
<400> 899
Asn Tyr Val Asp Ala Phe His Tyr Gly Asn Gln Asp Ile Ser Gly Asp
1 5 10 15
Lys
<210> 900
<211> 13
<212> PRT
<213> RESISTANCE GENE
<400> 900
Gln Ala Asp His Ala Ile Leu Val Phe Asp Gln Ala Arg
1 5 10
<210> 901
<211> 13
<212> PRT
<213> RESISTANCE GENE
<400> 901
Gln Ala Glu His Ala Leu Leu Val Phe Gly Gln Glu Arg
1 5 10
<210> 902
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 902
Gln Ala Ile Thr Lys
1 5
<210> 903
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 903
Gln Ala Met Leu Thr Glu Ala Asn Ser Asp Tyr Ile Ile Arg
1 5 10
<210> 904
<211> 11
<212> PRT
<213> RESISTANCE GENE
<400> 904
Gln Glu Val Gln Phe Val Ser Ala Leu Ala Arg
1 5 10
<210> 905
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 905
Gln Phe Ala Ser Ile Lys
1 5
<210> 906
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 906
Gln Gly Met Pro Gly Ser Ile Arg
1 5
<210> 907
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 907
Gln Gly Met Ser Gly Ser Ile Arg
1 5
<210> 908
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 908
Gln Gly Gln Thr Gln Gln Ser Tyr Gly Asn Asp Leu Ala Arg
1 5 10
<210> 909
<211> 13
<212> PRT
<213> RESISTANCE GENE
<400> 909
Gln Ile Asp Tyr Gly Asn Ala Asp Pro Ser Thr Ile Lys
1 5 10
<210> 910
<211> 13
<212> PRT
<213> RESISTANCE GENE
<400> 910
Gln Ile Asp Tyr Gly Asn Val Asp Pro Ser Thr Ile Lys
1 5 10
<210> 911
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 911
Gln Ile Gly Glu Ala Arg
1 5
<210> 912
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 912
Gln Ile Gly Gln Ala Arg
1 5
<210> 913
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 913
Gln Ile Met Leu Ile Glu Gln Thr Pro Ala Phe Thr Leu Arg
1 5 10
<210> 914
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 914
Gln Leu Gly Ser Ala Ile Asp Gln Phe Trp Leu Arg
1 5 10
<210> 915
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 915
Gln Leu His Asp Asn Lys
1 5
<210> 916
<211> 11
<212> PRT
<213> RESISTANCE GENE
<400> 916
Gln Leu Ile Phe Val His Thr Val Val Gln Lys
1 5 10
<210> 917
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 917
Gln Leu Ile Phe Val His Thr Val Val Gln Lys Pro Gly Lys
1 5 10
<210> 918
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 918
Gln Leu Pro Val Lys
1 5
<210> 919
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 919
Gln Leu Pro Val Lys Pro Arg
1 5
<210> 920
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 920
Gln Leu Ser Leu Asp Val Leu Asp Lys
1 5
<210> 921
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 921
Gln Leu Val Tyr Ala Arg
1 5
<210> 922
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 922
Gln Met Met Leu Thr Glu Ala Ser Thr Asp Tyr Ile Ile Arg
1 5 10
<210> 923
<211> 16
<212> PRT
<213> RESISTANCE GENE
<400> 923
Gln Met Ser Ile Val Glu Ala Thr Pro Asp Tyr Val Leu His Gly Lys
1 5 10 15
<210> 924
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 924
Gln Pro Thr Asp Pro Ala Arg
1 5
<210> 925
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 925
Gln Pro Thr Asp Pro Thr Arg
1 5
<210> 926
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 926
Gln Pro Val Ser Ala Gly Ile Arg
1 5
<210> 927
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 927
Gln Gln Leu Val Lys
1 5
<210> 928
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 928
Gln Thr Leu Val Phe Ala Arg
1 5
<210> 929
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 929
Gln Val Gly Ala Glu Lys
1 5
<210> 930
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 930
Gln Val Val Phe Ala Arg
1 5
<210> 931
<211> 11
<212> PRT
<213> RESISTANCE GENE
<400> 931
Ser Ala Asp Glu Val Leu Pro Tyr Gly Gly Lys
1 5 10
<210> 932
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 932
Ser Ala Asp Glu Val Leu Pro Tyr Gly Gly Lys Pro Gln Arg
1 5 10
<210> 933
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 933
Ser Cys Ala Thr Asn Asp Leu Ala Arg
1 5
<210> 934
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 934
Ser Cys Ala Thr Asn Asn Leu Ala Arg
1 5
<210> 935
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 935
Ser Asp Ile Pro Gly Gly Ser Lys
1 5
<210> 936
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 936
Ser Asp Trp Gly Lys
1 5
<210> 937
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 937
Ser Glu Asp Asn Phe His Ile Ser Ser Gln Gln His Glu Lys
1 5 10
<210> 938
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 938
Ser Glu Met Pro Ala Ser Ile Arg
1 5
<210> 939
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 939
Ser Glu Met Pro Ala Ser Thr Arg
1 5
<210> 940
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 940
Ser Phe Ala Ala His Asn Gln Asp Gln Asp Leu Arg
1 5 10
<210> 941
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 941
Ser Phe Ala Gly His Asn Lys
1 5
<210> 942
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 942
Ser Phe Ala Gly His Asn Gln Asp Gln Asp Leu Arg
1 5 10
<210> 943
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 943
Ser Phe Ala Gly His Asn Gln Asp Gln Asn Leu Arg
1 5 10
<210> 944
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 944
Ser Phe Leu Glu Ser Trp Ala Lys
1 5
<210> 945
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 945
Ser Phe Thr Ala Trp Glu Lys
1 5
<210> 946
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 946
Ser Phe Thr Thr Trp Glu Lys
1 5
<210> 947
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 947
Ser Gly Ser Gly Trp Leu Arg
1 5
<210> 948
<211> 20
<212> PRT
<213> RESISTANCE GENE
<400> 948
Ser Gly Trp Gly Met Ala Val Asp Pro Gln Val Gly Trp Tyr Val Gly
1 5 10 15
Phe Val Glu Lys
20
<210> 949
<211> 20
<212> PRT
<213> RESISTANCE GENE
<400> 949
Ser Gly Trp Gly Met Asp Val Ser Pro Gln Val Gly Trp Leu Thr Gly
1 5 10 15
Trp Val Glu Lys
20
<210> 950
<211> 20
<212> PRT
<213> RESISTANCE GENE
<400> 950
Ser Gly Trp Gly Met Asp Val Thr Pro Gln Val Gly Trp Leu Thr Gly
1 5 10 15
Trp Val Glu Lys
20
<210> 951
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 951
Ser Ile His Pro Ala Ser Thr Phe Lys
1 5
<210> 952
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 952
Ser Ile Pro Thr Lys
1 5
<210> 953
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 953
Ser Ile Ser Thr Lys
1 5
<210> 954
<211> 10
<212> PRT
<213> RESISTANCE GENE
<400> 954
Ser Leu Gly Leu Ser Asn Asn Leu Ser Arg
1 5 10
<210> 955
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 955
Ser Leu Ser Met Ser Gly Lys
1 5
<210> 956
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 956
Ser Met Leu Phe Ile Glu Glu Lys
1 5
<210> 957
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 957
Ser Asn Gly Glu Lys
1 5
<210> 958
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 958
Ser Asn Gly Leu Thr His Ser Trp Leu Gly Ser Ser Leu Lys
1 5 10
<210> 959
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 959
Ser Asn Gly Tyr Lys
1 5
<210> 960
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 960
Ser Pro Thr Trp Glu Leu Lys
1 5
<210> 961
<211> 15
<212> PRT
<213> RESISTANCE GENE
<400> 961
Ser Pro Thr Trp Glu Leu Lys Pro Glu Tyr Asn Pro Ser Pro Arg
1 5 10 15
<210> 962
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 962
Ser Gln Asp Ile Val Arg
1 5
<210> 963
<211> 13
<212> PRT
<213> RESISTANCE GENE
<400> 963
Ser Gln Gln Lys Pro Thr Asp Pro Thr Ile Trp Leu Lys
1 5 10
<210> 964
<211> 16
<212> PRT
<213> RESISTANCE GENE
<400> 964
Ser Gln Val Gly Trp Leu Thr Gly Trp Val Glu Gln Pro Asp Gly Lys
1 5 10 15
<210> 965
<211> 13
<212> PRT
<213> RESISTANCE GENE
<400> 965
Ser Ser Ser Asn Ser Cys Thr Thr Asn Asn Ala Ala Arg
1 5 10
<210> 966
<211> 13
<212> PRT
<213> RESISTANCE GENE
<400> 966
Ser Ser Ser Asn Ser Cys Thr Thr Asn Asn Ala Thr Arg
1 5 10
<210> 967
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 967
Ser Val Tyr Gly Glu Leu Arg
1 5
<210> 968
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 968
Ser Trp Ile Leu Arg
1 5
<210> 969
<211> 15
<212> PRT
<213> RESISTANCE GENE
<400> 969
Ser Tyr Phe Asp Glu Ala Gln Thr Gln Gly Val Ile Ile Ile Lys
1 5 10 15
<210> 970
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 970
Ser Tyr Leu Glu Lys
1 5
<210> 971
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 971
Ser Tyr Pro Met Trp Glu Lys
1 5
<210> 972
<211> 10
<212> PRT
<213> RESISTANCE GENE
<400> 972
Thr Ala Tyr Ile Pro Ala Ser Thr Phe Lys
1 5 10
<210> 973
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 973
Thr Asp Asp Leu Phe Lys
1 5
<210> 974
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 974
Thr Asp Ile Asn Glu Ile Phe Lys
1 5
<210> 975
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 975
Thr Phe Ile His Asn Asp Pro Arg
1 5
<210> 976
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 976
Thr Gly Ala Gly Phe Thr Ala Asn Arg
1 5
<210> 977
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 977
Thr Gly Phe Asn Asp Gly Gln Lys
1 5
<210> 978
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 978
Thr Gly Leu Ala Asp Ser Lys
1 5
<210> 979
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 979
Thr Gly Leu Asp Leu Met Gln Lys
1 5
<210> 980
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 980
Thr Gly Leu Glu Leu Met Gln Lys
1 5
<210> 981
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 981
Thr Gly Met Gly Tyr Pro Lys
1 5
<210> 982
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 982
Thr Gly Asn Gly Arg
1 5
<210> 983
<211> 10
<212> PRT
<213> RESISTANCE GENE
<400> 983
Thr Gly Thr Gly Ser Phe Ile Asp Ala Arg
1 5 10
<210> 984
<211> 10
<212> PRT
<213> RESISTANCE GENE
<400> 984
Thr Gly Thr Gly Ser Leu Ser Asp Ala Lys
1 5 10
<210> 985
<211> 20
<212> PRT
<213> RESISTANCE GENE
<400> 985
Thr Gly Val Ala Thr Glu Tyr Gln Pro Glu Ile Gly Trp Trp Ala Gly
1 5 10 15
Trp Val Glu Arg
20
<210> 986
<211> 13
<212> PRT
<213> RESISTANCE GENE
<400> 986
Thr Gly Val Ser Tyr Pro Leu Leu Ala Asp Gly Thr Arg
1 5 10
<210> 987
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 987
Thr Gly Trp Ala Ala Met Asp Ile Lys
1 5
<210> 988
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 988
Thr Gly Trp Ala Met Asp Ile Lys
1 5
<210> 989
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 989
Thr Gly Trp Ala Met Asp Val Lys
1 5
<210> 990
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 990
Thr Gly Trp Ala Thr Arg
1 5
<210> 991
<211> 19
<212> PRT
<213> RESISTANCE GENE
<400> 991
Thr Gly Trp Cys Phe Asp Cys Thr Pro Glu Leu Gly Trp Trp Val Gly
1 5 10 15
Trp Val Lys
<210> 992
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 992
Thr Gly Trp Glu Gly Arg
1 5
<210> 993
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 993
Thr Gly Trp Phe Val Asp Lys
1 5
<210> 994
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 994
Thr Gly Tyr Asp Thr Lys
1 5
<210> 995
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 995
Thr Gly Tyr Gly Val Arg
1 5
<210> 996
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 996
Thr Gly Tyr Ser Ala Arg
1 5
<210> 997
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 997
Thr Gly Tyr Ser Thr Arg
1 5
<210> 998
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 998
Thr His Glu Ser Ser Asn Trp Gly Lys
1 5
<210> 999
<211> 13
<212> PRT
<213> RESISTANCE GENE
<400> 999
Thr Ile Cys Thr Ala Ile Ala Asp Ala Gly Thr Gly Lys
1 5 10
<210> 1000
<211> 20
<212> PRT
<213> RESISTANCE GENE
<400> 1000
Thr Ile Gly Gly Ala Pro Asp Ala Tyr Trp Val Asp Asp Ser Leu Gln
1 5 10 15
Ile Ser Ala Arg
20
<210> 1001
<211> 13
<212> PRT
<213> RESISTANCE GENE
<400> 1001
Thr Leu Pro Phe Ser Ala Ser Ser Tyr Glu Thr Leu Arg
1 5 10
<210> 1002
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 1002
Thr Leu Pro Phe Ser Leu Lys
1 5
<210> 1003
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 1003
Thr Leu Pro Phe Ser Pro Lys
1 5
<210> 1004
<211> 21
<212> PRT
<213> RESISTANCE GENE
<400> 1004
Thr Leu Pro Phe Ser Gln Glu Val Gln Asp Glu Val Gln Ser Ile Leu
1 5 10 15
Phe Ile Glu Glu Lys
20
<210> 1005
<211> 21
<212> PRT
<213> RESISTANCE GENE
<400> 1005
Thr Leu Pro Phe Ser Gln Glu Val Gln Asp Glu Val Gln Ser Met Leu
1 5 10 15
Phe Ile Glu Glu Lys
20
<210> 1006
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 1006
Thr Leu Pro Phe Ser Gln Lys
1 5
<210> 1007
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 1007
Thr Leu Pro Ser Ser Gln Lys
1 5
<210> 1008
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 1008
Thr Leu Gln Asn Gly Trp Phe Glu Gly Phe Ile Ile Ser Lys
1 5 10
<210> 1009
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 1009
Thr Met Gln Glu Tyr Leu Asn Lys
1 5
<210> 1010
<211> 13
<212> PRT
<213> RESISTANCE GENE
<400> 1010
Thr Asn Gly Asn Ser Thr Ser Val Tyr Asn Glu Ser Arg
1 5 10
<210> 1011
<211> 11
<212> PRT
<213> RESISTANCE GENE
<400> 1011
Thr Gln Thr Tyr Gln Ala Tyr Asp Ala Ala Arg
1 5 10
<210> 1012
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 1012
Thr Thr Asp Pro Thr Ile Trp Glu Lys
1 5
<210> 1013
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 1013
Thr Thr Thr Thr Glu Val Phe Lys
1 5
<210> 1014
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 1014
Thr Trp Ala Ser Asn Asp Phe Ser Arg
1 5
<210> 1015
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 1015
Thr Trp Asp Met Val Gln Arg
1 5
<210> 1016
<211> 17
<212> PRT
<213> RESISTANCE GENE
<400> 1016
Thr Trp Met Gln Phe Ser Val Val Trp Val Ser Gln Glu Ile Thr Gln
1 5 10 15
Lys
<210> 1017
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 1017
Thr Tyr Pro Met Trp Glu Lys
1 5
<210> 1018
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 1018
Thr Tyr Val Val Asp Pro Ala Arg
1 5
<210> 1019
<211> 10
<212> PRT
<213> RESISTANCE GENE
<400> 1019
Val Ala Phe Ser Leu Asn Ile Glu Met Lys
1 5 10
<210> 1020
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 1020
Val Ala Asn Ser Leu Ile Gly Leu Ser Thr Gly Ala Val Arg
1 5 10
<210> 1021
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 1021
Val Glu His Gln Arg
1 5
<210> 1022
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 1022
Val Glu Leu Gly Lys
1 5
<210> 1023
<211> 20
<212> PRT
<213> RESISTANCE GENE
<400> 1023
Val Phe Asp Asp Ala Gly Val Ser Gly Thr Phe Val Leu Met Asp Ile
1 5 10 15
Thr Ala Asp Arg
20
<210> 1024
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 1024
Val Phe Leu Asp Ser Trp Ala Lys
1 5
<210> 1025
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 1025
Val Phe Leu Glu Ser Trp Ala Lys
1 5
<210> 1026
<211> 17
<212> PRT
<213> RESISTANCE GENE
<400> 1026
Val Phe Leu Ser Ser Trp Ala Gln Asp Met Asn Leu Ser Ser Ala Ile
1 5 10 15
Lys
<210> 1027
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 1027
Val Gly Phe Glu Arg
1 5
<210> 1028
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 1028
Val Ile Leu Val Phe Asp Gln Val Arg
1 5
<210> 1029
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 1029
Val Ile Thr Phe Thr Lys
1 5
<210> 1030
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 1030
Val Met Ala Ala Met Val Arg
1 5
<210> 1031
<211> 20
<212> PRT
<213> RESISTANCE GENE
<400> 1031
Val Pro Leu Ala Val Met Gly Tyr Asp Ala Gly Ile Leu Val Asp Ala
1 5 10 15
His Asn Pro Arg
20
<210> 1032
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 1032
Val Gln Ala Asn Val Lys
1 5
<210> 1033
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 1033
Val Gln Asp Glu Val Lys
1 5
<210> 1034
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 1034
Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu Lys
1 5 10
<210> 1035
<211> 18
<212> PRT
<213> RESISTANCE GENE
<400> 1035
Val Gln Asp Glu Val Gln Ser Met Leu Phe Ile Glu Glu Met Asn Gly
1 5 10 15
Asn Lys
<210> 1036
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 1036
Val Gln Asp Gly Val Gln Ser Met Leu Phe Ile Glu Glu Lys
1 5 10
<210> 1037
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 1037
Val Gln His Glu Val Gln Ser Met Leu Phe Ile Glu Glu Lys
1 5 10
<210> 1038
<211> 13
<212> PRT
<213> RESISTANCE GENE
<400> 1038
Val Ser Cys Leu Pro Cys Tyr Gln Val Val Ser His Lys
1 5 10
<210> 1039
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 1039
Val Ser Cys Val Trp Cys Tyr Gln Ala Leu Ala Arg
1 5 10
<210> 1040
<211> 17
<212> PRT
<213> RESISTANCE GENE
<400> 1040
Val Ser Asp Val Cys Ser Glu Val Thr Ala Glu Gly Trp Gln Glu Val
1 5 10 15
Arg
<210> 1041
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 1041
Val Ser Glu Val Glu Gly Trp Gln Ile His Gly Lys
1 5 10
<210> 1042
<211> 10
<212> PRT
<213> RESISTANCE GENE
<400> 1042
Val Ser Phe Ser Leu Asn Ile Glu Met Lys
1 5 10
<210> 1043
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 1043
Val Ser Pro Cys Ser Ser Phe Lys
1 5
<210> 1044
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 1044
Val Ser Gln Val Pro Ala Tyr Lys
1 5
<210> 1045
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 1045
Val Val Phe Ala Arg
1 5
<210> 1046
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 1046
Trp Asp Gly Ala Lys
1 5
<210> 1047
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 1047
Trp Asp Gly Glu Lys
1 5
<210> 1048
<211> 13
<212> PRT
<213> RESISTANCE GENE
<400> 1048
Trp Asp Gly His Ile Tyr Asp Phe Pro Asp Trp Asn Arg
1 5 10
<210> 1049
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 1049
Trp Asp Gly Ile Lys
1 5
<210> 1050
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 1050
Trp Asp Gly Lys Pro Arg
1 5
<210> 1051
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 1051
Trp Asp Gly Gln Lys
1 5
<210> 1052
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 1052
Trp Asp Gly Gln Thr Arg
1 5
<210> 1053
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 1053
Trp Asp Gly Val Lys
1 5
<210> 1054
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 1054
Trp Asp Gly Val Asn Arg
1 5
<210> 1055
<211> 11
<212> PRT
<213> RESISTANCE GENE
<400> 1055
Trp Asp Tyr Lys Pro Glu Phe Asn Gly Tyr Lys
1 5 10
<210> 1056
<211> 21
<212> PRT
<213> RESISTANCE GENE
<400> 1056
Trp Glu Thr Tyr Ser Val Val Trp Phe Ser Gln Gln Ile Thr Glu Trp
1 5 10 15
Leu Gly Met Glu Arg
20
<210> 1057
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 1057
Trp Asn Gly Gln Lys
1 5
<210> 1058
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 1058
Tyr Ala Gln Ala Lys
1 5
<210> 1059
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 1059
Tyr Phe Ser Asp Phe Asn Ala Lys
1 5
<210> 1060
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 1060
Tyr Gly Thr His Leu Asp Arg
1 5
<210> 1061
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 1061
Tyr Ile Ile His Asn Lys
1 5
<210> 1062
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 1062
Tyr Leu Asp Glu Leu Val Lys
1 5
<210> 1063
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 1063
Tyr Leu Met Ile Thr Glu Ala Gly Arg
1 5
<210> 1064
<211> 18
<212> PRT
<213> RESISTANCE GENE
<400> 1064
Tyr Leu Asn Leu Phe Ser Tyr Gly Asn Ala Asn Ile Gly Gly Gly Ile
1 5 10 15
Asp Lys
<210> 1065
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 1065
Tyr Asn Gly Glu Lys
1 5
<210> 1066
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 1066
Tyr Pro His Asn Pro Arg
1 5
<210> 1067
<211> 18
<212> PRT
<213> RESISTANCE GENE
<400> 1067
Tyr Pro Val Val Trp Tyr Ser Gln Gln Val Ala His His Leu Gly Ala
1 5 10 15
Gln Arg
<210> 1068
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 1068
Tyr Ser Asn Val Leu Ala Phe Lys
1 5
<210> 1069
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 1069
Tyr Ser Pro Ala Ser Thr Phe Lys
1 5
<210> 1070
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 1070
Tyr Ser Val Val Pro Val Tyr Gln Gln Leu Ala Arg
1 5 10
<210> 1071
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 1071
Tyr Ser Val Val Trp Tyr Ser Gln Leu Thr Ala Lys
1 5 10
<210> 1072
<211> 18
<212> PRT
<213> RESISTANCE GENE
<400> 1072
Tyr Ser Val Val Trp Tyr Ser Gln Gln Val Ala His His Leu Gly Ala
1 5 10 15
Gln Arg
<210> 1073
<211> 8
<212> PRT
<213> RESISTANCE GENE
<400> 1073
Tyr Thr Pro Ala Ser Thr Phe Lys
1 5
<210> 1074
<211> 18
<212> PRT
<213> RESISTANCE GENE
<400> 1074
Tyr Thr Ser Ala Phe Gly Tyr Gly Asn Ala Asp Val Ser Gly Glu Pro
1 5 10 15
Gly Lys
<210> 1075
<211> 20
<212> PRT
<213> RESISTANCE GENE
<400> 1075
Tyr Val Phe Val Ser Ala Leu Thr Gly Asn Leu Gly Ser Asn Leu Thr
1 5 10 15
Ser Ser Ile Lys
20
<210> 1076
<211> 20
<212> PRT
<213> RESISTANCE GENE
<400> 1076
Tyr Val Phe Val Ser Ala Leu Thr Gly Ser Leu Gly Ser Asn Leu Thr
1 5 10 15
Ser Ser Ile Lys
20
<210> 1077
<211> 6
<212> PRT
<213> RESISTANCE GENE
<400> 1077
Tyr Val Gly His Asp Arg
1 5
<210> 1078
<211> 270
<212> PRT
<213> RESISTANCE GENE
<400> 1078
Met Glu Leu Pro Asn Ile Met His Pro Val Ala Lys Leu Ser Thr Ala
1 5 10 15
Leu Ala Ala Ala Leu Met Leu Ser Gly Cys Met Ala Gly Glu Ile Arg
20 25 30
Pro Thr Ile Gly Gln Gln Met Glu Thr Gly Asp Gln Arg Phe Gly Asp
35 40 45
Leu Val Phe Arg Gln Leu Ala Pro Asn Val Trp Gln His Thr Ser Tyr
50 55 60
Leu Asp Met Pro Gly Phe Gly Ala Val Ala Ser Asn Gly Leu Ile Val
65 70 75 80
Arg Asp Gly Gly Arg Val Leu Val Val Asp Thr Ala Trp Thr Asp Asp
85 90 95
Gln Thr Ala Gln Ile Leu Asn Trp Ile Lys Gln Glu Ile Asn Leu Pro
100 105 110
Val Ala Leu Ala Val Val Thr His Ala His Gln Asp Lys Met Gly Gly
115 120 125
Met Asp Ala Leu His Ala Ala Gly Ile Ala Thr Tyr Ala Asn Ala Leu
130 135 140
Ser Asn Gln Leu Ala Pro Gln Glu Gly Met Val Ala Ala Gln His Ser
145 150 155 160
Leu Thr Phe Ala Ala Asn Gly Trp Val Glu Pro Ala Thr Ala Pro Asn
165 170 175
Phe Gly Pro Leu Lys Val Phe Tyr Pro Gly Pro Gly His Thr Ser Asp
180 185 190
Asn Ile Thr Val Gly Ile Asp Gly Thr Asp Ile Ala Phe Gly Gly Cys
195 200 205
Leu Ile Lys Asp Ser Lys Ala Lys Ser Leu Gly Asn Leu Gly Asp Ala
210 215 220
Asp Thr Glu His Tyr Ala Ala Ser Ala Arg Ala Phe Gly Ala Ala Phe
225 230 235 240
Pro Lys Ala Ser Met Ile Val Met Ser His Ser Ala Pro Asp Ser Arg
245 250 255
Ala Ala Ile Thr His Thr Ala Arg Met Ala Asp Lys Leu Arg
260 265 270
<210> 1079
<211> 270
<212> PRT
<213> RESISTANCE GENE
<400> 1079
Met Glu Leu Pro Asn Ile Met His Pro Val Ala Lys Leu Ser Thr Ala
1 5 10 15
Leu Ala Ala Ala Leu Met Leu Ser Gly Cys Met Pro Gly Glu Ile Arg
20 25 30
Pro Thr Ile Gly Gln Gln Met Glu Thr Gly Asp Gln Arg Phe Gly Asp
35 40 45
Leu Val Phe Arg Gln Leu Ala Pro Asn Val Trp Gln His Thr Ser Tyr
50 55 60
Leu Asp Met Pro Gly Phe Gly Ala Val Ala Ser Asn Gly Leu Ile Val
65 70 75 80
Arg Asp Gly Gly Arg Val Leu Leu Val Asp Thr Ala Trp Thr Asp Asp
85 90 95
Gln Thr Ala Gln Ile Leu Asn Trp Ile Lys Gln Glu Ile Asn Leu Pro
100 105 110
Val Ala Leu Ala Val Val Thr His Ala His Gln Asp Lys Met Gly Gly
115 120 125
Met Asp Ala Leu His Ala Ala Gly Ile Ala Thr Tyr Ala Asn Ala Leu
130 135 140
Ser Asn Gln Leu Ala Pro Gln Glu Gly Leu Val Ala Ala Gln His Ser
145 150 155 160
Leu Thr Phe Ala Ala Asn Gly Trp Val Glu Pro Ala Thr Ala Pro Asn
165 170 175
Phe Gly Pro Leu Lys Val Phe Tyr Pro Gly Pro Gly His Thr Ser Asp
180 185 190
Asn Ile Thr Val Gly Ile Asp Gly Thr Asp Ile Ala Phe Gly Gly Cys
195 200 205
Leu Ile Lys Asp Ser Lys Ala Lys Ser Leu Gly Asn Leu Gly Asp Ala
210 215 220
Asp Thr Glu His Tyr Ala Ala Ser Ala Arg Ala Phe Gly Ala Ala Phe
225 230 235 240
Pro Lys Ala Ser Met Ile Val Met Ser His Ser Ala Pro Asp Ser Arg
245 250 255
Ala Ala Ile Thr His Thr Ala Arg Met Ala Asp Lys Leu Arg
260 265 270
<210> 1080
<211> 270
<212> PRT
<213> RESISTANCE GENE
<400> 1080
Met Glu Leu Pro Asn Ile Met His Pro Val Ala Lys Leu Ser Thr Ala
1 5 10 15
Leu Ala Ala Ala Leu Met Leu Ser Gly Cys Met Pro Gly Glu Ile Arg
20 25 30
Pro Thr Ile Gly Gln Gln Met Glu Thr Gly Asp Gln Arg Phe Gly Asp
35 40 45
Leu Val Phe Arg Gln Leu Ala Pro Asn Val Trp Gln His Thr Ser Tyr
50 55 60
Leu Asp Met Pro Gly Phe Gly Ala Val Ala Ser Asn Gly Leu Ile Val
65 70 75 80
Arg Asp Gly Gly Arg Val Leu Val Val Asp Thr Ala Trp Thr Asp Asp
85 90 95
Gln Thr Ala Gln Ile Leu Asn Trp Ile Lys Gln Glu Ile Asn Leu Pro
100 105 110
Val Ala Leu Ala Val Val Thr His Ala His Gln Asp Lys Met Gly Gly
115 120 125
Met Asp Ala Leu His Ala Ala Gly Ile Ala Thr Tyr Ala Asn Ala Leu
130 135 140
Ser Asn Gln Leu Ala Pro Gln Glu Gly Met Val Ala Ala Gln His Ser
145 150 155 160
Leu Thr Phe Ala Ala Asn Gly Trp Val Glu Pro Ala Thr Ala Pro Asn
165 170 175
Phe Gly Pro Leu Lys Val Phe Tyr Pro Gly Pro Gly His Thr Ser Asp
180 185 190
Asn Ile Thr Val Gly Ile Asp Gly Thr Asp Ile Ala Phe Gly Gly Cys
195 200 205
Leu Ile Lys Asp Ser Lys Ala Lys Ser Leu Gly Asn Leu Gly Asp Ala
210 215 220
Asp Thr Glu His Tyr Ala Ala Ser Ala Arg Ala Phe Gly Ala Ala Phe
225 230 235 240
Pro Lys Ala Ser Met Ile Val Met Ser His Ser Ala Pro Asp Ser Arg
245 250 255
Ala Ala Ile Thr His Thr Ala Arg Met Ala Asp Lys Leu Arg
260 265 270
<210> 1081
<211> 20
<212> PRT
<213> RESISTANCE GENE
<400> 1081
Leu Ser Thr Ala Leu Ala Ala Ala Leu Met Leu Ser Gly Cys Met Ala
1 5 10 15
Gly Glu Ile Arg
20
<210> 1082
<211> 20
<212> PRT
<213> RESISTANCE GENE
<400> 1082
Leu Ser Thr Ala Leu Ala Ala Ala Leu Met Leu Ser Gly Cys Met Pro
1 5 10 15
Gly Glu Ile Arg
20
<210> 1083
<211> 21
<212> PRT
<213> RESISTANCE GENE
<400> 1083
Val Leu Leu Val Asp Thr Ala Trp Thr Asp Asp Gln Thr Ala Gln Ile
1 5 10 15
Leu Asn Trp Ile Lys
20
<210> 1084
<211> 293
<212> PRT
<213> RESISTANCE GENE
<400> 1084
Met Ser Leu Tyr Arg Arg Leu Val Leu Leu Ser Cys Leu Ser Trp Pro
1 5 10 15
Leu Ala Gly Phe Ser Ala Thr Ala Leu Thr Asn Leu Val Ala Glu Pro
20 25 30
Phe Ala Lys Leu Glu Gln Asp Phe Gly Gly Ser Ile Gly Val Tyr Ala
35 40 45
Met Asp Thr Gly Ser Gly Ala Thr Val Ser Tyr Arg Ala Glu Glu Arg
50 55 60
Phe Pro Leu Cys Ser Ser Phe Lys Gly Phe Leu Ala Ala Ala Val Leu
65 70 75 80
Ala Arg Ser Gln Gln Gln Ala Gly Leu Leu Asp Thr Pro Ile Arg Tyr
85 90 95
Gly Lys Asn Ala Leu Val Pro Trp Ser Pro Ile Ser Glu Lys Tyr Leu
100 105 110
Thr Thr Gly Met Thr Val Ala Glu Leu Ser Ala Ala Ala Val Gln Tyr
115 120 125
Ser Asp Asn Ala Ala Ala Asn Leu Leu Leu Lys Glu Leu Gly Gly Pro
130 135 140
Ala Gly Leu Thr Ala Phe Met Arg Ser Ile Gly Asp Thr Thr Phe Arg
145 150 155 160
Leu Asp Arg Trp Glu Leu Glu Leu Asn Ser Ala Ile Pro Gly Asp Ala
165 170 175
Arg Asp Thr Ser Ser Pro Arg Ala Val Thr Glu Ser Leu Gln Lys Leu
180 185 190
Thr Leu Gly Ser Ala Leu Ala Ala Pro Gln Arg Gln Gln Phe Val Asp
195 200 205
Trp Leu Lys Gly Asn Thr Thr Gly Asn His Arg Ile Arg Ala Ala Val
210 215 220
Pro Ala Asp Trp Ala Val Gly Asp Lys Thr Gly Thr Cys Gly Gly Tyr
225 230 235 240
Gly Thr Ala Asn Asp Tyr Ala Val Val Trp Pro Thr Gly Arg Ala Pro
245 250 255
Ile Val Leu Ala Val Tyr Thr Arg Ala Pro Asn Lys Asp Asp Lys His
260 265 270
Ser Glu Ala Val Ile Ala Ala Ala Ala Arg Leu Ala Leu Glu Gly Leu
275 280 285
Gly Val Asn Gly Gln
290
<210> 1085
<211> 293
<212> PRT
<213> RESISTANCE GENE
<400> 1085
Met Ser Leu Tyr Arg Arg Leu Val Leu Leu Ser Cys Leu Ser Trp Pro
1 5 10 15
Leu Ala Gly Phe Ser Ala Thr Ala Leu Thr Asn Leu Val Ala Glu Pro
20 25 30
Phe Ala Lys Leu Glu Gln Asp Phe Gly Gly Ser Ile Gly Val Tyr Ala
35 40 45
Met Asp Thr Gly Ser Gly Ala Thr Val Ser Tyr Arg Ala Glu Glu Arg
50 55 60
Phe Pro Leu Cys Ser Ser Phe Lys Gly Phe Leu Ala Ala Ala Val Leu
65 70 75 80
Ala Arg Ser Gln Gln Gln Ala Gly Leu Leu Asp Thr Pro Ile Arg Tyr
85 90 95
Gly Lys Asn Ala Leu Val Pro Trp Ser Pro Ile Ser Glu Lys Tyr Leu
100 105 110
Thr Thr Gly Met Thr Val Ala Glu Leu Ser Ala Ala Ala Val Gln Tyr
115 120 125
Ser Asp Asn Ala Ala Ala Asn Leu Leu Leu Lys Glu Leu Gly Gly Pro
130 135 140
Ala Gly Leu Thr Ala Phe Met Arg Ser Ile Gly Asp Thr Thr Phe Arg
145 150 155 160
Leu Asp Arg Trp Glu Leu Glu Leu Asn Ser Ala Ile Pro Gly Asp Ala
165 170 175
Arg Asp Thr Ser Ser Pro Arg Ala Val Thr Glu Ser Leu Gln Lys Leu
180 185 190
Thr Leu Gly Ser Ala Leu Ala Ala Pro Gln Arg Gln Gln Phe Val Asp
195 200 205
Trp Leu Lys Gly Asn Thr Thr Gly Asn His Arg Ile Arg Ala Ala Val
210 215 220
Pro Ala Asp Trp Ala Val Gly Asp Lys Thr Gly Thr Cys Gly Gly Tyr
225 230 235 240
Gly Thr Ala Asn Asp Tyr Ala Val Val Trp Pro Thr Gly Arg Ala Pro
245 250 255
Ile Val Leu Ala Val Tyr Thr Arg Ala Pro Asn Lys Asp Asp Lys Tyr
260 265 270
Ser Glu Ala Val Ile Ala Ala Ala Ala Arg Leu Ala Leu Glu Gly Leu
275 280 285
Gly Val Asn Gly Gln
290
<210> 1086
<211> 293
<212> PRT
<213> RESISTANCE GENE
<400> 1086
Met Ser Leu Tyr Arg Arg Leu Val Leu Leu Ser Cys Leu Ser Trp Pro
1 5 10 15
Leu Ala Gly Phe Ser Ala Thr Ala Leu Thr Asn Leu Val Ala Glu Pro
20 25 30
Phe Ala Lys Leu Glu Gln Asp Phe Gly Gly Ser Ile Gly Val Tyr Ala
35 40 45
Met Asp Thr Gly Ser Gly Ala Thr Val Ser Tyr Arg Ala Glu Glu Arg
50 55 60
Phe Pro Leu Cys Ser Ser Phe Lys Gly Phe Leu Ala Ala Ala Val Leu
65 70 75 80
Ala Arg Ser Gln Gln Gln Ala Gly Leu Leu Asp Thr Pro Ile Arg Tyr
85 90 95
Gly Lys Asn Ala Leu Val Pro Trp Ser Pro Ile Ser Glu Lys Tyr Leu
100 105 110
Thr Thr Gly Met Thr Val Ala Glu Leu Ser Ala Ala Ala Val Gln Tyr
115 120 125
Ser Asp Asn Ala Ala Ala Asn Leu Leu Leu Lys Glu Leu Gly Gly Pro
130 135 140
Ala Gly Leu Thr Ala Phe Met Arg Ser Ile Gly Asp Thr Thr Phe Arg
145 150 155 160
Leu Asp Arg Trp Glu Leu Glu Leu Asn Ser Ala Ile Pro Gly Asp Ala
165 170 175
Arg Asp Thr Ser Ser Pro Arg Ala Val Thr Glu Ser Leu Gln Lys Leu
180 185 190
Thr Leu Gly Ser Ala Leu Ala Ala Pro Gln Arg Gln Gln Phe Val Asp
195 200 205
Trp Leu Lys Gly Asn Thr Thr Gly Asn His Arg Ile Arg Ala Ala Val
210 215 220
Pro Ala Asp Trp Ala Val Gly Asp Lys Thr Gly Thr Cys Gly Val Tyr
225 230 235 240
Gly Thr Ala Asn Asp Tyr Ala Val Val Trp Pro Thr Gly Arg Ala Pro
245 250 255
Ile Val Leu Ala Val Tyr Thr Arg Ala Pro Asn Lys Asp Asp Lys His
260 265 270
Ser Glu Ala Val Ile Ala Ala Ala Ala Arg Leu Ala Leu Glu Gly Leu
275 280 285
Gly Val Asn Gly Gln
290
<210> 1087
<211> 293
<212> PRT
<213> RESISTANCE GENE
<400> 1087
Met Ser Leu Tyr Arg Arg Leu Val Leu Leu Ser Cys Leu Ser Trp Pro
1 5 10 15
Leu Ala Gly Phe Ser Ala Thr Ala Leu Thr Asn Leu Val Ala Glu Pro
20 25 30
Phe Ala Lys Leu Glu Gln Asp Phe Gly Gly Ser Ile Gly Val Tyr Ala
35 40 45
Met Asp Thr Gly Ser Gly Ala Thr Val Ser Tyr Arg Ala Glu Glu Arg
50 55 60
Phe Pro Leu Cys Ser Ser Phe Lys Gly Phe Leu Ala Ala Ala Val Leu
65 70 75 80
Ala Arg Ser Gln Gln Gln Ala Gly Leu Leu Asp Thr Pro Ile Arg Tyr
85 90 95
Gly Lys Asn Ala Leu Val Pro Trp Ser Pro Ile Ser Glu Lys Tyr Leu
100 105 110
Thr Thr Gly Met Thr Val Ala Glu Leu Ser Ala Ala Ala Val Gln Tyr
115 120 125
Ser Asp Asn Ala Ala Ala Asn Leu Leu Leu Lys Glu Leu Gly Gly Pro
130 135 140
Ala Gly Leu Thr Ala Phe Met Arg Ser Ile Gly Asp Thr Thr Phe Arg
145 150 155 160
Leu Asp Arg Trp Glu Leu Glu Leu Asn Ser Ala Ile Pro Gly Asp Ala
165 170 175
Arg Asp Thr Ser Ser Pro Arg Ala Val Thr Glu Ser Leu Gln Lys Leu
180 185 190
Thr Leu Gly Ser Ala Leu Ala Ala Pro Gln Arg Gln Gln Phe Val Asp
195 200 205
Trp Leu Lys Gly Asn Thr Thr Gly Asn His Arg Ile Arg Ala Ala Val
210 215 220
Pro Ala Asp Trp Ala Val Gly Asp Lys Thr Gly Thr Cys Gly Val Tyr
225 230 235 240
Gly Thr Ala Asn Asp Tyr Ala Val Val Trp Pro Thr Gly Arg Ala Pro
245 250 255
Ile Val Leu Ala Val Tyr Thr Arg Ala Pro Asn Lys Asp Asp Lys Tyr
260 265 270
Ser Glu Ala Val Ile Ala Ala Ala Ala Arg Leu Ala Leu Glu Gly Leu
275 280 285
Gly Val Asn Gly Gln
290
<210> 1088
<211> 293
<212> PRT
<213> RESISTANCE GENE
<400> 1088
Met Ser Leu Tyr Arg Arg Leu Val Leu Leu Ser Cys Leu Ser Trp Pro
1 5 10 15
Leu Ala Gly Phe Ser Ala Thr Ala Leu Thr Asn Leu Val Ala Glu Pro
20 25 30
Phe Ala Lys Leu Glu Gln Asp Phe Gly Gly Ser Ile Gly Val Tyr Ala
35 40 45
Met Asp Thr Gly Ser Gly Ala Thr Val Ser Tyr Arg Ala Glu Glu Arg
50 55 60
Phe Pro Leu Cys Ser Ser Phe Lys Gly Phe Leu Ala Ala Ala Val Leu
65 70 75 80
Ala Arg Ser Gln Gln Gln Ala Gly Leu Leu Asp Thr Pro Ile Arg Tyr
85 90 95
Gly Lys Asn Ala Leu Val Pro Trp Ser Pro Ile Ser Glu Lys Tyr Leu
100 105 110
Thr Thr Gly Met Thr Val Ala Glu Leu Ser Ala Ala Ala Val Gln Tyr
115 120 125
Ser Asp Asn Ala Ala Ala Asn Leu Leu Leu Lys Glu Leu Gly Gly Pro
130 135 140
Ala Gly Leu Thr Ala Phe Met Arg Ser Ile Gly Asp Thr Thr Phe Arg
145 150 155 160
Leu Asp Arg Trp Glu Leu Glu Leu Asn Ser Ala Ile Pro Ser Asp Ala
165 170 175
Arg Asp Thr Ser Ser Pro Arg Ala Val Thr Glu Ser Leu Gln Lys Leu
180 185 190
Thr Leu Gly Ser Ala Leu Ala Ala Pro Gln Arg Gln Gln Phe Val Asp
195 200 205
Trp Leu Lys Gly Asn Thr Thr Gly Asn His Arg Ile Arg Ala Ala Val
210 215 220
Pro Ala Asp Trp Ala Val Gly Asp Lys Thr Gly Thr Cys Gly Val Tyr
225 230 235 240
Gly Thr Ala Asn Asp Tyr Ala Val Val Trp Pro Thr Gly Arg Ala Pro
245 250 255
Ile Val Leu Ala Val Tyr Thr Arg Ala Pro Asn Lys Asp Asp Lys His
260 265 270
Ser Glu Ala Val Ile Ala Ala Ala Ala Arg Leu Ala Leu Glu Gly Leu
275 280 285
Gly Val Asn Gly Gln
290
<210> 1089
<211> 293
<212> PRT
<213> RESISTANCE GENE
<400> 1089
Met Ser Leu Tyr Arg Arg Leu Val Leu Leu Ser Cys Leu Ser Trp Pro
1 5 10 15
Leu Ala Gly Phe Ser Ala Thr Ala Leu Thr Asn Leu Val Ala Glu Pro
20 25 30
Phe Ala Lys Leu Glu Gln Asp Phe Gly Gly Ser Ile Gly Val Tyr Ala
35 40 45
Met Asp Thr Gly Ser Gly Ala Thr Val Ser Tyr Arg Ala Glu Glu Arg
50 55 60
Phe Pro Leu Cys Ser Ser Phe Lys Gly Phe Leu Ala Ala Ala Val Leu
65 70 75 80
Ala Arg Ser Gln Gln Gln Ala Gly Leu Leu Asp Thr Pro Ile Arg Tyr
85 90 95
Gly Lys Asn Ala Leu Val Pro Trp Ser Pro Ile Ser Glu Lys Tyr Leu
100 105 110
Thr Thr Gly Met Thr Val Ala Glu Leu Ser Ala Ala Ala Val Gln Tyr
115 120 125
Ser Asp Asn Ala Ala Ala Asn Leu Leu Leu Lys Glu Leu Gly Gly Pro
130 135 140
Ala Gly Leu Thr Ala Phe Met Arg Ser Ile Gly Asp Thr Thr Phe Arg
145 150 155 160
Leu Asp Arg Trp Glu Leu Glu Met Asn Ser Ala Ile Pro Gly Asp Ala
165 170 175
Arg Asp Thr Ser Ser Pro Arg Ala Val Thr Glu Ser Leu Gln Lys Leu
180 185 190
Thr Leu Gly Ser Ala Leu Ala Ala Pro Gln Arg Gln Gln Phe Val Asp
195 200 205
Trp Leu Lys Gly Asn Thr Thr Gly Asn His Arg Ile Arg Ala Ala Val
210 215 220
Pro Ala Asp Trp Ala Val Gly Asp Lys Thr Gly Thr Cys Gly Val Tyr
225 230 235 240
Gly Thr Ala Asn Asp Tyr Ala Val Val Trp Pro Thr Gly Arg Ala Pro
245 250 255
Ile Val Leu Ala Val Tyr Thr Arg Ala Pro Asn Lys Asp Asp Lys His
260 265 270
Ser Glu Ala Val Ile Ala Ala Ala Ala Arg Leu Ala Leu Glu Gly Leu
275 280 285
Gly Val Asn Gly Gln
290
<210> 1090
<211> 293
<212> PRT
<213> RESISTANCE GENE
<400> 1090
Met Ser Leu Tyr Arg Arg Leu Val Leu Leu Ser Cys Leu Ser Trp Pro
1 5 10 15
Leu Ala Gly Phe Ser Ala Thr Ala Leu Thr Asn Leu Val Ala Glu Pro
20 25 30
Phe Ala Lys Leu Glu Gln Asp Phe Gly Gly Ser Ile Gly Val Tyr Ala
35 40 45
Met Asp Thr Gly Ser Gly Ala Thr Val Ser Tyr Arg Ala Glu Glu Arg
50 55 60
Phe Pro Leu Cys Ser Ser Phe Lys Gly Phe Leu Ala Ala Ala Val Leu
65 70 75 80
Ala Arg Ser Gln Gln Gln Ala Gly Leu Leu Asp Thr Pro Ile Arg Tyr
85 90 95
Gly Lys Asn Ala Leu Val Arg Trp Ser Pro Ile Ser Glu Lys Tyr Leu
100 105 110
Thr Thr Gly Met Thr Val Ala Glu Leu Ser Ala Ala Ala Val Gln Tyr
115 120 125
Ser Asp Asn Ala Ala Ala Asn Leu Leu Leu Lys Glu Leu Gly Gly Pro
130 135 140
Ala Gly Leu Thr Ala Phe Met Arg Ser Ile Gly Asp Thr Thr Phe Arg
145 150 155 160
Leu Asp Arg Trp Glu Leu Glu Leu Asn Ser Ala Ile Pro Gly Asp Ala
165 170 175
Arg Asp Thr Ser Ser Pro Arg Ala Val Thr Glu Ser Leu Gln Lys Leu
180 185 190
Thr Leu Gly Ser Ala Leu Ala Ala Pro Gln Arg Gln Gln Phe Val Asp
195 200 205
Trp Leu Lys Gly Asn Thr Thr Gly Asn His Arg Ile Arg Ala Ala Val
210 215 220
Pro Ala Asp Trp Ala Val Gly Asp Lys Thr Gly Thr Cys Gly Val Tyr
225 230 235 240
Gly Thr Ala Asn Asp Tyr Ala Val Val Trp Pro Thr Gly Arg Ala Pro
245 250 255
Ile Val Leu Ala Val Tyr Thr Arg Ala Pro Asn Lys Asp Asp Lys His
260 265 270
Ser Glu Ala Val Ile Ala Ala Ala Ala Arg Leu Ala Leu Glu Gly Leu
275 280 285
Gly Val Asn Gly Gln
290
<210> 1091
<211> 293
<212> PRT
<213> RESISTANCE GENE
<400> 1091
Met Ser Leu Tyr Arg Arg Leu Val Leu Leu Ser Cys Leu Ser Trp Pro
1 5 10 15
Leu Ala Gly Phe Ser Ala Thr Ala Leu Thr Asn Leu Val Ala Glu Pro
20 25 30
Phe Ala Lys Leu Glu Gln Asp Phe Gly Gly Ser Ile Gly Val Tyr Ala
35 40 45
Met Asp Thr Gly Ser Gly Ala Thr Val Ser Tyr Arg Ala Glu Glu Arg
50 55 60
Phe Pro Leu Cys Ser Ser Phe Lys Gly Phe Leu Ala Ala Ala Val Leu
65 70 75 80
Ala Arg Ser Gln Gln Gln Ala Gly Leu Leu Asp Thr Pro Ile Arg Tyr
85 90 95
Gly Lys Asn Ala Leu Val Arg Trp Ser Pro Ile Ser Glu Lys Tyr Leu
100 105 110
Thr Thr Gly Met Thr Val Ala Glu Leu Ser Ala Ala Ala Val Gln Tyr
115 120 125
Ser Asp Asn Ala Ala Ala Asn Leu Leu Leu Lys Glu Leu Gly Gly Pro
130 135 140
Ala Gly Leu Thr Ala Phe Met Arg Ser Ile Gly Asp Thr Thr Phe Arg
145 150 155 160
Leu Asp Arg Trp Glu Leu Glu Leu Asn Ser Ala Ile Pro Gly Asp Ala
165 170 175
Arg Asp Thr Ser Ser Pro Arg Ala Val Thr Glu Ser Leu Gln Lys Leu
180 185 190
Thr Leu Gly Ser Ala Leu Ala Ala Pro Gln Arg Gln Gln Phe Val Asp
195 200 205
Trp Leu Lys Gly Asn Thr Thr Gly Asn His Arg Ile Arg Ala Ala Val
210 215 220
Pro Ala Asp Trp Ala Val Gly Asp Lys Thr Gly Thr Cys Gly Val Tyr
225 230 235 240
Gly Thr Ala Asn Asp Tyr Ala Val Val Trp Pro Thr Gly Arg Ala Pro
245 250 255
Ile Val Leu Ala Val Tyr Thr Arg Ala Pro Asn Lys Asp Asp Lys Tyr
260 265 270
Ser Glu Ala Val Ile Ala Ala Ala Ala Arg Leu Ala Leu Glu Gly Leu
275 280 285
Gly Val Asn Gly Gln
290
<210> 1092
<211> 284
<212> PRT
<213> RESISTANCE GENE
<400> 1092
Arg Leu Val Leu Leu Ser Cys Leu Ser Trp Pro Leu Ala Gly Phe Ser
1 5 10 15
Ala Thr Ala Leu Thr Asn Leu Val Ala Glu Pro Phe Ala Lys Leu Glu
20 25 30
Gln Asp Phe Gly Gly Ser Ile Gly Val Tyr Ala Met Asp Thr Gly Ser
35 40 45
Gly Ala Thr Val Ser Tyr Arg Ala Glu Glu Arg Phe Pro Leu Cys Ser
50 55 60
Ser Phe Lys Gly Phe Leu Ala Ala Ala Val Leu Ala Arg Ser Gln Gln
65 70 75 80
Gln Ala Gly Leu Leu Asp Thr Pro Ile Arg Tyr Gly Lys Asn Ala Leu
85 90 95
Val Pro Trp Ser Pro Ile Ser Glu Lys Tyr Leu Thr Thr Gly Met Thr
100 105 110
Val Ala Glu Leu Ser Ala Ala Ala Val Gln Tyr Ser Asp Asn Ala Ala
115 120 125
Ala Asn Leu Leu Leu Lys Glu Leu Gly Gly Pro Ala Gly Leu Thr Ala
130 135 140
Phe Met Arg Ser Ile Gly Asp Thr Thr Phe Arg Leu Asp Arg Trp Glu
145 150 155 160
Leu Glu Leu Asn Ser Ala Ile Pro Gly Asp Ala Arg Asp Thr Ser Ser
165 170 175
Pro Arg Ala Val Thr Glu Ser Leu Gln Lys Leu Thr Leu Gly Ser Ala
180 185 190
Leu Ala Ala Pro Gln Arg Gln Gln Phe Val Asp Trp Leu Lys Gly Asn
195 200 205
Thr Thr Gly Asn His Arg Ile Arg Ala Ala Val Pro Ala Asp Trp Ala
210 215 220
Val Gly Asp Lys Thr Gly Thr Cys Gly Ala Tyr Gly Thr Ala Asn Asp
225 230 235 240
Tyr Ala Val Val Trp Pro Thr Gly Arg Ala Pro Ile Val Leu Ala Val
245 250 255
Tyr Thr Arg Ala Pro Asn Lys Asp Asp Lys Tyr Ser Glu Ala Val Ile
260 265 270
Ala Ala Ala Ala Arg Leu Ala Leu Glu Gly Leu Gly
275 280
<210> 1093
<211> 292
<212> PRT
<213> RESISTANCE GENE
<400> 1093
Ser Leu Tyr Arg Arg Leu Val Leu Leu Ser Cys Leu Ser Trp Pro Leu
1 5 10 15
Ala Gly Phe Ser Ala Thr Ala Leu Thr Asn Leu Val Ala Glu Pro Phe
20 25 30
Ala Lys Leu Glu Gln Asp Phe Gly Gly Ser Ile Gly Val Tyr Ala Met
35 40 45
Asp Thr Gly Ser Gly Ala Thr Val Ser Tyr Arg Ala Glu Glu Arg Phe
50 55 60
Pro Leu Cys Ser Ser Phe Lys Gly Phe Leu Ala Ala Ala Val Leu Ala
65 70 75 80
Arg Ser Gln Gln Gln Ala Gly Leu Leu Asp Thr Pro Ile Arg Tyr Gly
85 90 95
Lys Asn Ala Leu Val Arg Trp Ser Pro Ile Ser Glu Lys Tyr Leu Thr
100 105 110
Thr Gly Met Thr Val Ala Glu Leu Ser Ala Ala Ala Val Gln Tyr Ser
115 120 125
Asp Asn Ala Ala Ala Asn Leu Leu Leu Lys Glu Leu Gly Gly Pro Ala
130 135 140
Gly Leu Thr Ala Phe Met Arg Ser Ile Gly Asp Thr Thr Phe Arg Leu
145 150 155 160
Asp Arg Trp Glu Leu Glu Leu Asn Ser Ala Ile Pro Gly Asp Ala Arg
165 170 175
Asp Thr Ser Ser Pro Arg Ala Val Thr Glu Ser Leu Gln Lys Leu Thr
180 185 190
Leu Gly Ser Ala Leu Ala Ala Pro Gln Arg Gln Gln Phe Val Asp Trp
195 200 205
Leu Lys Gly Asn Thr Thr Gly Asn His Arg Ile Arg Ala Ala Val Pro
210 215 220
Ala Asp Trp Ala Val Gly Asp Lys Thr Gly Thr Cys Gly Gly Tyr Gly
225 230 235 240
Thr Ala Asn Asp Tyr Ala Val Val Trp Pro Thr Gly Arg Ala Pro Ile
245 250 255
Val Leu Ala Val Tyr Thr Arg Ala Pro Asn Lys Asp Asp Lys His Ser
260 265 270
Glu Ala Val Ile Ala Ala Ala Ala Arg Leu Ala Leu Glu Gly Leu Gly
275 280 285
Val Asn Gly Gln
290
<210> 1094
<211> 5
<212> PRT
<213> RESISTANCE GENE
<400> 1094
Asn Ala Leu Val Arg
1 5
<210> 1095
<211> 21
<212> PRT
<213> RESISTANCE GENE
<400> 1095
Thr Gly Thr Cys Gly Ala Tyr Gly Thr Ala Asn Asp Tyr Ala Val Val
1 5 10 15
Trp Pro Thr Gly Arg
20
<210> 1096
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 1096
Trp Glu Leu Glu Leu Asn Ser Ala Ile Pro Ser Asp Ala Arg
1 5 10
<210> 1097
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 1097
Trp Glu Leu Glu Met Asn Ser Ala Ile Pro Gly Asp Ala Arg
1 5 10
<210> 1098
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 1098
Ala Asn Gln Ala Phe Leu Pro Ala Ser Thr Phe Lys
1 5 10
<210> 1099
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 1099
Asp Glu His Gln Val Phe Lys
1 5
<210> 1100
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 1100
Asp His Asn Leu Ile Thr Ala Met Lys
1 5
<210> 1101
<211> 7
<212> PRT
<213> RESISTANCE GENE
<400> 1101
Asp Ile Ala Thr Trp Asn Arg
1 5
<210> 1102
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 1102
Ile Pro Asn Ser Leu Ile Ala Leu Asp Leu Gly Val Val Lys
1 5 10
<210> 1103
<211> 11
<212> PRT
<213> RESISTANCE GENE
<400> 1103
Ile Ser Ala Thr Glu Gln Ile Ser Phe Leu Arg
1 5 10
<210> 1104
<211> 14
<212> PRT
<213> RESISTANCE GENE
<400> 1104
Gln Ala Met Leu Thr Glu Ala Asn Gly Asp Tyr Ile Ile Arg
1 5 10
<210> 1105
<211> 9
<212> PRT
<213> RESISTANCE GENE
<400> 1105
Gln Gln Gly Phe Thr Asn Asn Leu Lys
1 5
<210> 1106
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 1106
Ser Gln Gly Val Val Val Leu Trp Asn Glu Asn Lys
1 5 10
<210> 1107
<211> 10
<212> PRT
<213> RESISTANCE GENE
<400> 1107
Ser Trp Asn Ala His Phe Thr Glu His Lys
1 5 10
<210> 1108
<211> 21
<212> PRT
<213> RESISTANCE GENE
<400> 1108
Val Leu Ala Leu Ser Ala Val Phe Leu Val Ala Ser Ile Ile Gly Met
1 5 10 15
Pro Ala Val Ala Lys
20
<210> 1109
<211> 12
<212> PRT
<213> RESISTANCE GENE
<400> 1109
Tyr Ser Val Val Pro Val Tyr Gln Glu Phe Ala Arg
1 5 10
1
NTD131501

Claims (24)

1.一种通过多反应监测模式下串联型质谱检测样品中至少一种微生物针对至少一种抗菌剂碳青霉烯的至少一种抗性标记的方法，其中所述至少一种抗性标记是OXA肽，所述OXA肽选自由以下氨基酸序列的肽组成的组：SEQ ID No.509到SEQ ID No.523、SEQ IDNo.525到SEQ ID No.572、SEQ ID No.574到SEQ ID No.604、SEQ ID No.606到SEQ IDNo.618、SEQ ID No.620到SEQ ID No.696、SEQ ID No.698到SEQ ID No.1077以及SEQ IDNo.1098到SEQ ID No.1109。
2.权利要求1的检测方法，其中所述抗性标记是来源于所述至少一种微生物的蛋白质。
3.权利要求2的检测方法，其中来源于所述微生物的蛋白质被消化成肽。
4.权利要求3的检测方法，其中用酶进行所述消化。
5.权利要求4的检测方法，其中所述酶是胰蛋白酶。
6.权利要求1的检测方法，其中所述抗性标记进一步包括至少一种选自NDM、GES、IMP、IND、SME和VIM型的蛋白质或肽。
7.权利要求6的检测方法，其中所述抗性标记是选自序列为SEQ ID No.2到SEQ IDNo.9以及SEQ ID No.1083的肽的NDM肽。
8.权利要求7的检测方法，其中所述抗性标记是选自序列为SEQ ID No.2、SEQ IDNo.3、SEQ ID No.5或SEQ ID No.7的肽的NDM标记。
9.权利要求1的检测方法，其中所述抗性标记是选自序列为SEQ ID No.509、SEQ IDNo.510、SEQ ID No.512、SEQ ID No.513、SEQ ID No.514、SEQ ID No.515、SEQ ID No.516、SEQ ID No.517、SEQ ID No.518、SEQ ID No.519、SEQ ID No.520、SEQ ID No.521、SEQ IDNo.522、SEQ ID No.523、SEQ ID No.525、SEQ ID No.526、SEQ ID No.528、SEQ ID No.530、SEQ ID No.531、SEQ ID No.532、SEQ ID No.533、SEQ ID No.534、SEQ ID No.535、SEQ IDNo.536、SEQ ID No.537、SEQ ID No.538、SEQ ID No.539、SEQ ID No.540、SEQ ID No.541、SEQ ID No.542、SEQ ID No.543、SEQ ID No.544、SEQ ID No.545、SEQ ID No.546、SEQ IDNo.547、SEQ ID No.548、SEQ ID No.549、SEQ ID No.550、SEQ ID No.551、SEQ ID No.552、SEQ ID No.553、SEQ ID No.554、SEQ ID No.555、SEQ ID No.556、SEQ ID No.557、SEQ IDNo.558、SEQ ID No.559、SEQ ID No.560、SEQ ID No.561、SEQ ID No.562、SEQ ID No.563、SEQ ID No.564、SEQ ID No.565、SEQ ID No.566、SEQ ID No.567、SEQ ID No.571、SEQ IDNo.572、SEQ ID No.574、SEQ ID No.575、SEQ ID No.576、SEQ ID No.577、SEQ ID No.578、SEQ ID No.580、SEQ ID No.581、SEQ ID No.583、SEQ ID No.584、SEQ ID No.586、SEQ IDNo.587、SEQ ID No.588、SEQ ID No.589、SEQ ID No.590、SEQ ID No.591、SEQ ID No.593、SEQ ID No.594、SEQ ID No.595、SEQ ID No.596、SEQ ID No.597、SEQ ID No.598、SEQ IDNo.599、SEQ ID No.600、SEQ ID No.601、SEQ ID No.602、SEQ ID No.604、SEQ ID No.606、SEQ ID No.607、SEQ ID No.609、SEQ ID No.611、SEQ ID No.612、SEQ ID No.613、SEQ IDNo.614、SEQ ID No.615、SEQ ID No.616、SEQ ID No.618、SEQ ID No.620、SEQ ID No.622、SEQ ID No.623、SEQ ID No.624、SEQ ID No.625、SEQ ID No.626、SEQ ID No.627、SEQ IDNo.632、SEQ ID No.633、SEQ ID No.635、SEQ ID No.636、SEQ ID No.637、SEQ ID No.638、SEQ ID No.639、SEQ ID No.640、SEQ ID No.641、SEQ ID No.642、SEQ ID No.643、SEQ IDNo.645、SEQ ID No.648、SEQ ID No.649、SEQ ID No.651、SEQ ID No.652、SEQ ID No.653、SEQ ID No.654、SEQ ID No.655、SEQ ID No.656、SEQ ID No.659、SEQ ID No.660、SEQ IDNo.664、SEQ ID No.665、SEQ ID No.666、SEQ ID No.667、SEQ ID No.669、SEQ ID No.670、SEQ ID No.672、SEQ ID No.673、SEQ ID No.674、SEQ ID No.675、SEQ ID No.676、SEQ IDNo.677、SEQ ID No.678、SEQ ID No.679、SEQ ID No.680、SEQ ID No.681、SEQ ID No.685、SEQ ID No.686、SEQ ID No.687、SEQ ID No.688、SEQ ID No.689、SEQ ID No.690、SEQ IDNo.691、SEQ ID No.692、SEQ ID No.693、SEQ ID No.694、SEQ ID No.696、SEQ ID No.698、SEQ ID No.699、SEQ ID No.700、SEQ ID No.701、SEQ ID No.702、SEQ ID No.703、SEQ IDNo.706、SEQ ID No.707、SEQ ID No.710、SEQ ID No.714、SEQ ID No.717、SEQ ID No.719、SEQ ID No.720、SEQ ID No.722、SEQ ID No.725、SEQ ID No.726、SEQ ID No.727、SEQ IDNo.728、SEQ ID No.729、SEQ ID No.732、SEQ ID No.735、SEQ ID No.736、SEQ ID No.737、SEQ ID No.738、SEQ ID No.740、SEQ ID No.741、SEQ ID No.743、SEQ ID No.744、SEQ IDNo.745、SEQ ID No.746、SEQ ID No.747、SEQ ID No.748、SEQ ID No.749、SEQ ID No.750、SEQ ID No.751、SEQ ID No.752、SEQ ID No.753、SEQ ID No.754、SEQ ID No.755、SEQ IDNo.756、SEQ ID No.757、SEQ ID No.759、SEQ ID No.760、SEQ ID No.762、SEQ ID No.763、SEQ ID No.766、SEQ ID No.767、SEQ ID No.768、SEQ ID No.769、SEQ ID No.770、SEQ IDNo.771、SEQ ID No.773、SEQ ID No.774、SEQ ID No.775、SEQ ID No.776、SEQ ID No.777、SEQ ID No.778、SEQ ID No.779、SEQ ID No.780、SEQ ID No.781、SEQ ID No.782、SEQ IDNo.783、SEQ ID No.785、SEQ ID No.786、SEQ ID No.787、SEQ ID No.788、SEQ ID No.789、SEQ ID No.790、SEQ ID No.792、SEQ ID No.793、SEQ ID No.794、SEQ ID No.795、SEQ IDNo.796、SEQ ID No.797、SEQ ID No.798、SEQ ID No.799、SEQ ID No.800、SEQ ID No.801、SEQ ID No.803、SEQ ID No.804、SEQ ID No.805、SEQ ID No.806、SEQ ID No.807、SEQ IDNo.809、SEQ ID No.810、SEQ ID No.811、SEQ ID No.812、SEQ ID No.813、SEQ ID No.814、SEQ ID No.815、SEQ ID No.818、SEQ ID No.821、SEQ ID No.822、SEQ ID No.824、SEQ IDNo.825、SEQ ID No.826、SEQ ID No.827、SEQ ID No.828、SEQ ID No.829、SEQ ID No.830、SEQ ID No.831、SEQ ID No.832、SEQ ID No.833、SEQ ID No.834、SEQ ID No.835、SEQ IDNo.836、SEQ ID No.837、SEQ ID No.838、SEQ ID No.840、SEQ ID No.841、SEQ ID No.842、SEQ ID No.844、SEQ ID No.845、SEQ ID No.846、SEQ ID No.847、SEQ ID No.848、SEQ IDNo.849、SEQ ID No.850、SEQ ID No.851、SEQ ID No.853、SEQ ID No.854、SEQ ID No.855、SEQ ID No.856、SEQ ID No.857、SEQ ID No.858、SEQ ID No.859、SEQ ID No.860、SEQ IDNo.861、SEQ ID No.862、SEQ ID No.865、SEQ ID No.866、SEQ ID No.867、SEQ ID No.868、SEQ ID No.869、SEQ ID No.871、SEQ ID No.874、SEQ ID No.875、SEQ ID No.876、SEQ IDNo.877、SEQ ID No.878、SEQ ID No.879、SEQ ID No.880、SEQ ID No.881、SEQ ID No.882、SEQ ID No.883、SEQ ID No.884、SEQ ID No.885、SEQ ID No.886、SEQ ID No.887、SEQ IDNo.888、SEQ ID No.889、SEQ ID No.890、SEQ ID No.891、SEQ ID No.892、SEQ ID No.893、SEQ ID No.894、SEQ ID No.895、SEQ ID No.896、SEQ ID No.897、SEQ ID No.898、SEQ IDNo.899、SEQ ID No.900、SEQ ID No.901、SEQ ID No.902、SEQ ID No.903、SEQ ID No.904、SEQ ID No.905、SEQ ID No.906、SEQ ID No.907、SEQ ID No.908、SEQ ID No.909、SEQ IDNo.910、SEQ ID No.912、SEQ ID No.913、SEQ ID No.914、SEQ ID No.918、SEQ ID No.920、SEQ ID No.921、SEQ ID No.922、SEQ ID No.923、SEQ ID No.928、SEQ ID No.930、SEQ IDNo.932、SEQ ID No.935、SEQ ID No.936、SEQ ID No.937、SEQ ID No.938、SEQ ID No.939、SEQ ID No.940、SEQ ID No.941、SEQ ID No.942、SEQ ID No.943、SEQ ID No.944、SEQ IDNo.945、SEQ ID No.946、SEQ ID No.947、SEQ ID No.948、SEQ ID No.949、SEQ ID No.950、SEQ ID No.951、SEQ ID No.953、SEQ ID No.954、SEQ ID No.955、SEQ ID No.956、SEQ IDNo.958、SEQ ID No.961、SEQ ID No.962、SEQ ID No.963、SEQ ID No.964、SEQ ID No.967、SEQ ID No.968、SEQ ID No.970、SEQ ID No.972、SEQ ID No.973、SEQ ID No.974、SEQ IDNo.975、SEQ ID No.976、SEQ ID No.977、SEQ ID No.978、SEQ ID No.979、SEQ ID No.980、SEQ ID No.981、SEQ ID No.982、SEQ ID No.983、SEQ ID No.984、SEQ ID No.985、SEQ IDNo.986、SEQ ID No.988、SEQ ID No.990、SEQ ID No.992、SEQ ID No.993、SEQ ID No.994、SEQ ID No.995、SEQ ID No.996、SEQ ID No.997、SEQ ID No.998、SEQ ID No.1000、SEQ IDNo.1001、SEQ ID No.1003、SEQ ID No.1004、SEQ ID No.1005、SEQ ID No.1008、SEQ IDNo.1009、SEQ ID No.1011、SEQ ID No.1012、SEQ ID No.1013、SEQ ID No.1014、SEQ IDNo.1015、SEQ ID No.1018、SEQ ID No.1019、SEQ ID No.1020、SEQ ID No.1022、SEQ IDNo.1024、SEQ ID No.1025、SEQ ID No.1026、SEQ ID No.1027、SEQ ID No.1028、SEQ IDNo.1030、SEQ ID No.1031、SEQ ID No.1034、SEQ ID No.1036、SEQ ID No.1041、SEQ IDNo.1042、SEQ ID No.1044、SEQ ID No.1045、SEQ ID No.1046、SEQ ID No.1048、SEQ IDNo.1049、SEQ ID No.1050、SEQ ID No.1052、SEQ ID No.1053、SEQ ID No.1054、SEQ IDNo.1058、SEQ ID No.1059、SEQ ID No.1060、SEQ ID No.1062、SEQ ID No.1063、SEQ IDNo.1064、SEQ ID No.1067、SEQ ID No.1068、SEQ ID No.1069、SEQ ID No.1070、SEQ IDNo.1071、SEQ ID No.1072、SEQ ID No.1073、SEQ ID No.1074、SEQ ID No.1075、SEQ IDNo.1076、SEQ ID No.1098、SEQ ID No.1099、SEQ ID No.1100、SEQ ID No.1101、SEQ IDNo.1102、SEQ ID No.1103、SEQ ID No.1104、SEQ ID No.1105、SEQ ID No.1106、SEQ IDNo.1107、SEQ ID No.1108、SEQ ID No.1109的肽的OXA标记。
10.权利要求1的检测方法，其中所述抗性标记是选自序列为SEQ ID No.510、512、513、514、520、521、522、523、525、530、532、537、541、542、543、544、545、546、547、548、549、550、551、552、556、557、558、559、560、561、562、574、581、582、583、584、596、597、598、599、600、601、602、607、609、632、633、635、636、649、655、656、667、674、675、689、690、698、714、719、720、722、727、729、741、746、748、750、751、752、755、756、757、763、767、768、772、775、781、782、790、792、793、794、795、796、797、798、801、809、811、812、813、814、824、832、834、837、838、847、851、853、854、855、856、857、858、859、860、862、868、869、870、874、875、876、877、879、880、881、882、894、895、898、902、903、904、906、907、908、912、913、914、920、922、923、937、938、939、945、946、948、949、950、951、954、956、962、964、967、969、971、972、974、975、979、980、985、988、990、993、994、995、996、997、1000、1001、1003、1004、1005、1011、1013、1015、1018、1019、1027、1030、1034、1035、1036、1042、1048、1052、1058、1060、1070、1098、1099、1100、1101、1102、1103、1104、1105、1106、1107、1108、1109的肽的OXA标记。
11.权利要求1的检测方法，其中所述抗性标记是选自序列为SEQ ID No.1098、SEQ IDNo.1100、SEQ ID No.1102、SEQ ID No.1103、SEQ ID No.1104、SEQ ID No.1105、SEQ IDNo.1107、SEQ ID No.1108、SEQ ID No.1109的肽的OXA标记。
12.权利要求6的检测方法，其中所述抗性标记是选自序列为SEQ ID No.51、SEQ IDNo.52、SEQ ID No.54到SEQ ID No.58、SEQ ID No.61到SEQ ID No.75、SEQ ID No.77到SEQID No.79的肽的GES标记。
13.权利要求12的检测方法，其中所述抗性标记是选自序列为SEQ ID No.51、61、64、70、73、74、79的肽的GES标记。
14.权利要求12的检测方法，其中所述抗性标记是选自序列为SEQ ID No.54、55、66、67、68、69、71、77、78的肽的GES标记。
15.权利要求6的检测方法，其中所述抗性标记是选自序列为SEQ ID No.106、SEQ IDNo.108到SEQ ID No.130、SEQ ID No.133到SEQ ID No.173、SEQ ID No.175到SEQ IDNo.180的肽的IMP标记。
16.权利要求15的检测方法，其中所述抗性标记是选自序列为SEQ ID No.106、SEQ IDNo.108、SEQ ID No.109、SEQ ID No.110、SEQ ID No.112、SEQ ID No.113、SEQ ID No.115、SEQ ID No.116、SEQ ID No.117、SEQ ID No.118、SEQ ID No.121、SEQ ID No.124、SEQ IDNo.126、SEQ ID No.127、SEQ ID No.128、SEQ ID No.129、SEQ ID No.130、SEQ ID No.133、SEQ ID No.134、SEQ ID No.135、SEQ ID No.136、SEQ ID No.137、SEQ ID No.138、SEQ IDNo.139、SEQ ID No.140、SEQ ID No.141、SEQ ID No.142、SEQ ID No.143、SEQ ID No.144、SEQ ID No.145、SEQ ID No.146、SEQ ID No.147、SEQ ID No.148、SEQ ID No.149、SEQ IDNo.150、SEQ ID No.151、SEQ ID No.152、SEQ ID No.153、SEQ ID No.154、SEQ ID No.155、SEQ ID No.156、SEQ ID No.157、SEQ ID No.158、SEQ ID No.159、SEQ ID No.160、SEQ IDNo.161、SEQ ID No.162、SEQ ID No.163、SEQ ID No.164、SEQ ID No.165、SEQ ID No.166、SEQ ID No.167、SEQ ID No.168、SEQ ID No.169、SEQ ID No.170、SEQ ID No.171、SEQ IDNo.172、SEQ ID No.173、SEQ ID No.175、SEQ ID No.176、SEQ ID No.177、SEQ ID No.179、SEQ ID No.180的肽的IMP标记。
17.权利要求15或16的检测方法，其中所述抗性标记是选自序列为SEQ ID No.109、SEQID No.143、SEQ ID No.144、SEQ ID No.148、SEQ ID No.149、SEQ ID No.150、SEQ IDNo.151、SEQ ID No.154、SEQ ID No.155、SEQ ID No.156、SEQ ID No.159、SEQ ID No.165、SEQ ID No.169、SEQ ID No.170、SEQ ID No.171、SEQ ID No.172、SEQ ID No.173的肽的IMP标记。
18.权利要求6的检测方法，其中所述抗性标记是选自序列为SEQ ID No.188到SEQ IDNo.197、SEQ ID No.200、SEQ ID No.201、SEQ ID No.203到SEQ ID No.262的肽的IND标记。
19.权利要求18的检测方法，其中所述抗性标记是选自序列为SEQ ID No.188、SEQ IDNo.189、SEQ ID No.190、SEQ ID No.191、SEQ ID No.192、SEQ ID No.193、SEQ ID No.194、SEQ ID No.195、SEQ ID No.197、SEQ ID No.201、SEQ ID No.203、SEQ ID No.204、SEQ IDNo.205、SEQ ID No.206、SEQ ID No.207、SEQ ID No.208、SEQ ID No.209、SEQ ID No.210、SEQ ID No.211、SEQ ID No.212、SEQ ID No.213、SEQ ID No.215、SEQ ID No.216、SEQ IDNo.218、SEQ ID No.219、SEQ ID No.220、SEQ ID No.221、SEQ ID No.222、SEQ ID No.225、SEQ ID No.226、SEQ ID No.227、SEQ ID No.228、SEQ ID No.233、SEQ ID No.234、SEQ IDNo.235、SEQ ID No.236、SEQ ID No.237、SEQ ID No.238、SEQ ID No.239、SEQ ID No.240、SEQ ID No.241、SEQ ID No.242、SEQ ID No.243、SEQ ID No.244、SEQ ID No.245、SEQ IDNo.246、SEQ ID No.247、SEQ ID No.248、SEQ ID No.249、SEQ ID No.250、SEQ ID No.251、SEQ ID No.252、SEQ ID No.253、SEQ ID No.254、SEQ ID No.255、SEQ ID No.256、SEQ IDNo.257、SEQ ID No.258、SEQ ID No.259、SEQ ID No.260、SEQ ID No.261、SEQ ID No.262的肽的IND标记。
20.权利要求18的检测方法，其中所述抗性标记是选自序列为SEQ ID No.188、SEQ IDNo.193、SEQ ID No.207、SEQ ID No.242、SEQ ID No.243、SEQ ID No.246、SEQ ID No.256、SEQ ID No.260的肽的IND标记。
21.权利要求6的检测方法，其中所述抗性标记是选自序列为SEQ ID No.266到SEQ IDNo.281以及SEQ ID No.283到SEQ ID No.287的肽的SME标记。
22.权利要求21的检测方法，其中所述抗性标记是选自序列为SEQ ID No.266、SEQ IDNo.268、SEQ ID No.269、SEQ ID No.270、SEQ ID No.273、SEQ ID No.274、SEQ ID No.277、SEQ ID No.279、SEQ ID No.281的肽的SME标记。
23.权利要求6的检测方法，其中所述抗性标记是选自序列为SEQ ID No.314到SEQ IDNo.318以及SEQ ID No.320到SEQ ID No.346的肽的VIM标记。
24.权利要求23的检测方法，其中所述抗性标记是选自序列为SEQ ID No.316、SEQ IDNo.318、SEQ ID No.321、SEQ ID No.341、SEQ ID No.342、SEQ ID No.344、SEQ ID No.346的肽的VIM标记。
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CN107271686A (zh) 2017-10-20
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