CN107670016A - 一种用于乳腺病的经皮肤给药制品及其制备方法 - Google Patents
一种用于乳腺病的经皮肤给药制品及其制备方法 Download PDFInfo
- Publication number
- CN107670016A CN107670016A CN201711176595.6A CN201711176595A CN107670016A CN 107670016 A CN107670016 A CN 107670016A CN 201711176595 A CN201711176595 A CN 201711176595A CN 107670016 A CN107670016 A CN 107670016A
- Authority
- CN
- China
- Prior art keywords
- dried
- rhizome
- chinese
- preparation
- product
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 30
- 238000012377 drug delivery Methods 0.000 title claims abstract description 10
- 238000004519 manufacturing process Methods 0.000 title abstract description 5
- 239000003814 drug Substances 0.000 claims abstract description 95
- 238000000855 fermentation Methods 0.000 claims abstract description 47
- 230000004151 fermentation Effects 0.000 claims abstract description 46
- 229940079593 drug Drugs 0.000 claims abstract description 43
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 42
- 244000202052 Poncirus trifoliata Species 0.000 claims abstract description 29
- 235000000404 Poncirus trifoliata Nutrition 0.000 claims abstract description 29
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 26
- 239000001257 hydrogen Substances 0.000 claims abstract description 26
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 26
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 claims abstract description 20
- 240000003146 Lobelia chinensis Species 0.000 claims abstract description 20
- 244000036905 Benincasa cerifera Species 0.000 claims abstract description 19
- 241000255789 Bombyx mori Species 0.000 claims abstract description 19
- 244000020518 Carthamus tinctorius Species 0.000 claims abstract description 19
- 241000522254 Cassia Species 0.000 claims abstract description 19
- 244000247747 Coptis groenlandica Species 0.000 claims abstract description 19
- 235000002991 Coptis groenlandica Nutrition 0.000 claims abstract description 19
- 235000014375 Curcuma Nutrition 0.000 claims abstract description 19
- 235000003405 Curcuma zedoaria Nutrition 0.000 claims abstract description 19
- 240000009138 Curcuma zedoaria Species 0.000 claims abstract description 19
- 240000000691 Houttuynia cordata Species 0.000 claims abstract description 19
- 235000000802 Leonurus cardiaca ssp. villosus Nutrition 0.000 claims abstract description 19
- 235000008708 Morus alba Nutrition 0.000 claims abstract description 19
- 240000000249 Morus alba Species 0.000 claims abstract description 19
- 240000007164 Salvia officinalis Species 0.000 claims abstract description 19
- 239000001812 curcuma zedoaria berg. rosc. Substances 0.000 claims abstract description 19
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 claims abstract description 19
- 235000005412 red sage Nutrition 0.000 claims abstract description 19
- 235000019509 white turmeric Nutrition 0.000 claims abstract description 19
- 241000031023 Amana edulis Species 0.000 claims abstract description 18
- 235000011274 Benincasa cerifera Nutrition 0.000 claims abstract description 18
- 235000003255 Carthamus tinctorius Nutrition 0.000 claims abstract description 18
- 241000202567 Fatsia japonica Species 0.000 claims abstract description 18
- 241000405414 Rehmannia Species 0.000 claims abstract description 18
- 239000004575 stone Substances 0.000 claims abstract description 18
- 235000013717 Houttuynia Nutrition 0.000 claims abstract description 17
- 240000001659 Oldenlandia diffusa Species 0.000 claims abstract description 17
- 241000522190 Desmodium Species 0.000 claims abstract description 16
- 241000233866 Fungi Species 0.000 claims abstract description 14
- 239000006286 aqueous extract Substances 0.000 claims abstract description 11
- 238000000605 extraction Methods 0.000 claims abstract description 11
- 241000221638 Morchella Species 0.000 claims abstract description 9
- 244000164480 Curcuma aromatica Species 0.000 claims abstract 6
- 150000004676 glycans Chemical class 0.000 claims description 45
- 229920001282 polysaccharide Polymers 0.000 claims description 45
- 239000005017 polysaccharide Substances 0.000 claims description 45
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 35
- 238000003756 stirring Methods 0.000 claims description 29
- 239000000843 powder Substances 0.000 claims description 25
- 239000003921 oil Substances 0.000 claims description 20
- 235000019198 oils Nutrition 0.000 claims description 20
- 239000000203 mixture Substances 0.000 claims description 19
- 239000000284 extract Substances 0.000 claims description 18
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 18
- 238000001556 precipitation Methods 0.000 claims description 18
- 241000218691 Cupressaceae Species 0.000 claims description 16
- 238000001035 drying Methods 0.000 claims description 15
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 15
- 239000008158 vegetable oil Substances 0.000 claims description 15
- 239000007787 solid Substances 0.000 claims description 14
- 244000025254 Cannabis sativa Species 0.000 claims description 13
- 241000894007 species Species 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 11
- 238000010438 heat treatment Methods 0.000 claims description 10
- 150000001298 alcohols Chemical class 0.000 claims description 9
- 238000011026 diafiltration Methods 0.000 claims description 9
- 239000007788 liquid Substances 0.000 claims description 9
- 239000002994 raw material Substances 0.000 claims description 9
- 239000002893 slag Substances 0.000 claims description 9
- 238000010792 warming Methods 0.000 claims description 9
- 230000008595 infiltration Effects 0.000 claims description 8
- 238000001764 infiltration Methods 0.000 claims description 8
- 238000001694 spray drying Methods 0.000 claims description 8
- 241000353097 Molva molva Species 0.000 claims description 7
- 239000006071 cream Substances 0.000 claims description 7
- 238000009472 formulation Methods 0.000 claims description 7
- 239000006210 lotion Substances 0.000 claims description 7
- 239000000463 material Substances 0.000 claims description 7
- 238000003809 water extraction Methods 0.000 claims description 7
- 239000008157 edible vegetable oil Substances 0.000 claims description 4
- 241000157511 Oldenlandia Species 0.000 claims description 2
- 239000000443 aerosol Substances 0.000 claims description 2
- 238000007865 diluting Methods 0.000 claims description 2
- 239000000839 emulsion Substances 0.000 claims description 2
- 239000000499 gel Substances 0.000 claims description 2
- 239000000865 liniment Substances 0.000 claims description 2
- 229940040145 liniment Drugs 0.000 claims description 2
- 239000002674 ointment Substances 0.000 claims description 2
- 240000007890 Leonurus cardiaca Species 0.000 claims 5
- 240000002853 Nelumbo nucifera Species 0.000 claims 2
- 235000006508 Nelumbo nucifera Nutrition 0.000 claims 2
- 235000006510 Nelumbo pentapetala Nutrition 0.000 claims 2
- 241001674345 Callitropsis nootkatensis Species 0.000 claims 1
- 239000006072 paste Substances 0.000 claims 1
- 238000005507 spraying Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 18
- 244000192528 Chrysanthemum parthenium Species 0.000 abstract description 14
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 8
- 238000011161 development Methods 0.000 abstract description 6
- 201000010099 disease Diseases 0.000 abstract description 6
- 230000036039 immunity Effects 0.000 abstract description 3
- 231100000331 toxic Toxicity 0.000 abstract description 3
- 230000002588 toxic effect Effects 0.000 abstract description 3
- 239000002904 solvent Substances 0.000 abstract description 2
- 244000301850 Cupressus sempervirens Species 0.000 abstract 1
- 239000000047 product Substances 0.000 description 24
- 244000163122 Curcuma domestica Species 0.000 description 14
- 210000000481 breast Anatomy 0.000 description 13
- 241000723418 Carya Species 0.000 description 12
- 238000005516 engineering process Methods 0.000 description 10
- 239000003643 water by type Substances 0.000 description 10
- 241000196324 Embryophyta Species 0.000 description 9
- 206010006298 Breast pain Diseases 0.000 description 8
- 208000006662 Mastodynia Diseases 0.000 description 8
- 208000002193 Pain Diseases 0.000 description 8
- 210000005075 mammary gland Anatomy 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 241000894006 Bacteria Species 0.000 description 7
- 239000011505 plaster Substances 0.000 description 7
- 238000001816 cooling Methods 0.000 description 6
- 238000001514 detection method Methods 0.000 description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 5
- 239000012141 concentrate Substances 0.000 description 5
- 230000018109 developmental process Effects 0.000 description 5
- 238000002513 implantation Methods 0.000 description 5
- 239000000741 silica gel Substances 0.000 description 5
- 229910002027 silica gel Inorganic materials 0.000 description 5
- 230000001225 therapeutic effect Effects 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- 241000244987 Daiswa polyphylla Species 0.000 description 4
- 206010017553 Furuncle Diseases 0.000 description 4
- 208000027418 Wounds and injury Diseases 0.000 description 4
- 230000036461 convulsion Effects 0.000 description 4
- 230000002124 endocrine Effects 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 241000411851 herbal medicine Species 0.000 description 4
- 206010020718 hyperplasia Diseases 0.000 description 4
- 210000004185 liver Anatomy 0.000 description 4
- 235000015097 nutrients Nutrition 0.000 description 4
- 231100000614 poison Toxicity 0.000 description 4
- 206010006187 Breast cancer Diseases 0.000 description 3
- 208000026310 Breast neoplasm Diseases 0.000 description 3
- 206010007247 Carbuncle Diseases 0.000 description 3
- 206010010904 Convulsion Diseases 0.000 description 3
- 241000594394 Hedyotis Species 0.000 description 3
- 240000002769 Morchella esculenta Species 0.000 description 3
- 235000002779 Morchella esculenta Nutrition 0.000 description 3
- 206010030113 Oedema Diseases 0.000 description 3
- 235000019082 Osmanthus Nutrition 0.000 description 3
- 241000333181 Osmanthus Species 0.000 description 3
- 241000270295 Serpentes Species 0.000 description 3
- 208000004078 Snake Bites Diseases 0.000 description 3
- 230000000857 drug effect Effects 0.000 description 3
- 208000003512 furunculosis Diseases 0.000 description 3
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 3
- 229910052737 gold Inorganic materials 0.000 description 3
- 239000010931 gold Substances 0.000 description 3
- 230000003821 menstrual periods Effects 0.000 description 3
- 230000001717 pathogenic effect Effects 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 239000003440 toxic substance Substances 0.000 description 3
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 2
- 244000037364 Cinnamomum aromaticum Species 0.000 description 2
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 description 2
- 244000183685 Citrus aurantium Species 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- 235000013719 Houttuynia cordata Nutrition 0.000 description 2
- 206010062717 Increased upper airway secretion Diseases 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 206010023126 Jaundice Diseases 0.000 description 2
- 241000207925 Leonurus Species 0.000 description 2
- 241000112528 Ligusticum striatum Species 0.000 description 2
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 208000004880 Polyuria Diseases 0.000 description 2
- 244000273928 Zingiber officinale Species 0.000 description 2
- 235000006886 Zingiber officinale Nutrition 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 210000000038 chest Anatomy 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000035619 diuresis Effects 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 235000008397 ginger Nutrition 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 201000007227 lymph node tuberculosis Diseases 0.000 description 2
- 239000002398 materia medica Substances 0.000 description 2
- 230000005906 menstruation Effects 0.000 description 2
- 238000009629 microbiological culture Methods 0.000 description 2
- 230000027758 ovulation cycle Effects 0.000 description 2
- 238000009931 pascalization Methods 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 208000026435 phlegm Diseases 0.000 description 2
- 239000006187 pill Substances 0.000 description 2
- 239000002574 poison Substances 0.000 description 2
- 238000004321 preservation Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000007670 refining Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 231100000765 toxin Toxicity 0.000 description 2
- 239000003053 toxin Substances 0.000 description 2
- 201000008827 tuberculosis Diseases 0.000 description 2
- 231100000611 venom Toxicity 0.000 description 2
- GCKMFJBGXUYNAG-UHFFFAOYSA-N 17alpha-methyltestosterone Natural products C1CC2=CC(=O)CCC2(C)C2C1C1CCC(C)(O)C1(C)CC2 GCKMFJBGXUYNAG-UHFFFAOYSA-N 0.000 description 1
- 241001523383 Achnatherum Species 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 241000272520 Aix galericulata Species 0.000 description 1
- 244000233890 Alisma plantago Species 0.000 description 1
- 235000017300 Alisma plantago Nutrition 0.000 description 1
- 241000382455 Angelica sinensis Species 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 206010003011 Appendicitis Diseases 0.000 description 1
- 235000004359 Artemisia pontica Nutrition 0.000 description 1
- 235000003261 Artemisia vulgaris Nutrition 0.000 description 1
- 240000006891 Artemisia vulgaris Species 0.000 description 1
- 206010003445 Ascites Diseases 0.000 description 1
- 241000751139 Beauveria bassiana Species 0.000 description 1
- 208000003014 Bites and Stings Diseases 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 206010006223 Breast discharge Diseases 0.000 description 1
- 206010006458 Bronchitis chronic Diseases 0.000 description 1
- 241000983856 Calanthe davidii Species 0.000 description 1
- 244000080208 Canella winterana Species 0.000 description 1
- 235000008499 Canella winterana Nutrition 0.000 description 1
- 240000008574 Capsicum frutescens Species 0.000 description 1
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 description 1
- 235000021511 Cinnamomum cassia Nutrition 0.000 description 1
- 240000002319 Citrus sinensis Species 0.000 description 1
- 235000005976 Citrus sinensis Nutrition 0.000 description 1
- 241000037740 Coptis chinensis Species 0.000 description 1
- 241001573881 Corolla Species 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 241000846172 Cremastra appendiculata Species 0.000 description 1
- 241000125183 Crithmum maritimum Species 0.000 description 1
- 235000003392 Curcuma domestica Nutrition 0.000 description 1
- 241000963421 Curcuma kwangsiensis Species 0.000 description 1
- 235000003397 Curcuma kwangsiensis Nutrition 0.000 description 1
- 240000005629 Curcuma phaeocaulis Species 0.000 description 1
- 241000963390 Curcuma wenyujin Species 0.000 description 1
- 235000003394 Curcuma wenyujin Nutrition 0.000 description 1
- 206010012335 Dependence Diseases 0.000 description 1
- 208000020401 Depressive disease Diseases 0.000 description 1
- 244000231598 Dichorisandra thyrsiflora Species 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 206010013935 Dysmenorrhoea Diseases 0.000 description 1
- 206010013954 Dysphoria Diseases 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 206010016613 Fibroadenoma of breast Diseases 0.000 description 1
- 244000299452 Gouania lupuloides Species 0.000 description 1
- 235000000292 Gouania lupuloides Nutrition 0.000 description 1
- 241000237903 Hirudo Species 0.000 description 1
- 241000218228 Humulus Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 241000221781 Hypocreaceae Species 0.000 description 1
- 208000006877 Insect Bites and Stings Diseases 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 240000008415 Lactuca sativa Species 0.000 description 1
- 241000207923 Lamiaceae Species 0.000 description 1
- 240000003271 Leonurus japonicus Species 0.000 description 1
- 241000729196 Lycopus lucidus Species 0.000 description 1
- 208000008771 Lymphadenopathy Diseases 0.000 description 1
- 241001571764 Lysimachia christinae Species 0.000 description 1
- 244000304222 Melaleuca cajuputi Species 0.000 description 1
- 235000001167 Melaleuca cajuputi Nutrition 0.000 description 1
- 208000019255 Menstrual disease Diseases 0.000 description 1
- 206010027336 Menstruation delayed Diseases 0.000 description 1
- 241000361919 Metaphire sieboldi Species 0.000 description 1
- GCKMFJBGXUYNAG-HLXURNFRSA-N Methyltestosterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@](C)(O)[C@@]1(C)CC2 GCKMFJBGXUYNAG-HLXURNFRSA-N 0.000 description 1
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 description 1
- 241000218231 Moraceae Species 0.000 description 1
- 240000000157 Morchella angusticeps Species 0.000 description 1
- 235000012860 Morchella angusticeps Nutrition 0.000 description 1
- 241000221639 Morchella conica Species 0.000 description 1
- 241000896101 Morchella crassipes Species 0.000 description 1
- 241001058745 Morchella deliciosa Species 0.000 description 1
- 241000221637 Morchellaceae Species 0.000 description 1
- 208000024818 Nipple disease Diseases 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 206010030124 Oedema peripheral Diseases 0.000 description 1
- 241001248610 Ophiocordyceps sinensis Species 0.000 description 1
- 244000020477 Ottelia alismoides Species 0.000 description 1
- 240000004928 Paspalum scrobiculatum Species 0.000 description 1
- 235000003675 Paspalum scrobiculatum Nutrition 0.000 description 1
- 235000019483 Peanut oil Nutrition 0.000 description 1
- 208000029082 Pelvic Inflammatory Disease Diseases 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- 241001079007 Phellodendron chinense Species 0.000 description 1
- 241000013557 Plantaginaceae Species 0.000 description 1
- 241001250598 Pleione bulbocodioides Species 0.000 description 1
- 241001457446 Pleione yunnanensis Species 0.000 description 1
- 241000133806 Pogonarthria squarrosa Species 0.000 description 1
- 241000218201 Ranunculaceae Species 0.000 description 1
- 235000019484 Rapeseed oil Nutrition 0.000 description 1
- 241000405911 Rehmannia glutinosa Species 0.000 description 1
- 241001107098 Rubiaceae Species 0.000 description 1
- 206010049677 Salpingo-oophoritis Diseases 0.000 description 1
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 description 1
- 241000758742 Saururaceae Species 0.000 description 1
- 241000207929 Scutellaria Species 0.000 description 1
- 235000017089 Scutellaria baicalensis Nutrition 0.000 description 1
- 240000004534 Scutellaria baicalensis Species 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 235000019486 Sunflower oil Nutrition 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 208000031737 Tissue Adhesions Diseases 0.000 description 1
- 206010053476 Traumatic haemorrhage Diseases 0.000 description 1
- 241000233945 Typhaceae Species 0.000 description 1
- 240000000124 Typhonium roxburghii Species 0.000 description 1
- 240000004922 Vigna radiata Species 0.000 description 1
- 235000010721 Vigna radiata var radiata Nutrition 0.000 description 1
- 235000011469 Vigna radiata var sublobata Nutrition 0.000 description 1
- 208000031971 Yin Deficiency Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 206010000269 abscess Diseases 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 208000013228 adenopathy Diseases 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000001741 anti-phlogistic effect Effects 0.000 description 1
- 229940124584 antitussives Drugs 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000002146 bilateral effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 201000003149 breast fibroadenoma Diseases 0.000 description 1
- 206010006451 bronchitis Diseases 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 208000007451 chronic bronchitis Diseases 0.000 description 1
- 235000019504 cigarettes Nutrition 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000039 congener Substances 0.000 description 1
- 235000012343 cottonseed oil Nutrition 0.000 description 1
- 239000002385 cottonseed oil Substances 0.000 description 1
- 235000003373 curcuma longa Nutrition 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 230000002996 emotional effect Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 206010015037 epilepsy Diseases 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 235000008384 feverfew Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 208000021760 high fever Diseases 0.000 description 1
- 230000002390 hyperplastic effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 229910052738 indium Inorganic materials 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 230000006651 lactation Effects 0.000 description 1
- 210000000867 larynx Anatomy 0.000 description 1
- XMFOQHDPRMAJNU-UHFFFAOYSA-N lead(ii,iv) oxide Chemical compound O1[Pb]O[Pb]11O[Pb]O1 XMFOQHDPRMAJNU-UHFFFAOYSA-N 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- 208000004396 mastitis Diseases 0.000 description 1
- 201000003102 mental depression Diseases 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229960001566 methyltestosterone Drugs 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 229910052750 molybdenum Inorganic materials 0.000 description 1
- 239000011733 molybdenum Substances 0.000 description 1
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
- 235000019796 monopotassium phosphate Nutrition 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 239000013588 oral product Substances 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 229940023569 palmate Drugs 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 239000012165 plant wax Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000012286 potassium permanganate Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 235000020995 raw meat Nutrition 0.000 description 1
- 244000132619 red sage Species 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 230000005070 ripening Effects 0.000 description 1
- 235000012045 salad Nutrition 0.000 description 1
- 201000004409 schistosomiasis Diseases 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000002600 sunflower oil Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 206010044008 tonsillitis Diseases 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 230000010415 tropism Effects 0.000 description 1
- 235000013976 turmeric Nutrition 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 208000019206 urinary tract infection Diseases 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 239000008675 zhuhuang Substances 0.000 description 1
- 239000001841 zingiber officinale Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/533—Leonurus (motherwort)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/748—Oldenlandia or Hedyotis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/78—Saururaceae (Lizard's-tail family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/902—Sparganiaceae (Bur-reed family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0041—Mammary glands, e.g. breasts, udder; Intramammary administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Insects & Arthropods (AREA)
- Neurosurgery (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
本发明“一种用于乳腺病的经皮肤给药制品及其制备方法”，属于中医药领域，是以下原料药的水提取液与黑木耳、羊肚菌母种原液进行共发酵所得的产物；所述原料药具有以下重量份配比：益母草10，丹参10，当归10，川穹10，红花10，肉桂10，泽兰10，枳石10，枳壳10，黄莲10，黄柏10，黄芩10，生地10，山棱10，莪术10，山慈菇10，竹黄10，鱼腥草10，金钱草10，白花蛇舌草10，半枝莲10，半边莲10，蚤休10，八角金盘10，僵蚕10，地龙干10，生姜皮5，冬瓜皮5，桑叶5；所述原料药的水提取液是采用富氢水为提取溶剂。所述制品用于治疗乳腺病，疗效好，无毒副作用，使用方便，及时减缓病情发展，提高患者免疫力，显著改善患者生存质量。
Description
技术领域
本发明涉及中医制品及其加工技术，特别是涉及一种用于乳腺病的经皮肤给药制品及其制备方法。
技术背景
乳腺病通常表现为是乳房疼痛、乳内肿块。乳房疼痛多为乳腺炎导致，发生在哺乳期，呈胀痛或搏动性痛，兼有红、肿、热现象，患处变硬，且先期出现乳头皲裂，这多是乳腺炎。若一侧乳房呈间歇性弥漫性钝痛、串痛，或局限性隐痛、刺痛，且与月经周期和情绪变化有关联者，要考虑乳腺上皮增生。乳腺癌晚期因病灶侵击神经，也可出现乳房剧痛。乳腺囊性增生病、乳房结核、乳房结核、乳腺纤维腺瘤、乳腺癌早期都可能出现乳内肿块，可归为乳腺增生类疾病。乳腺增生是乳腺组织导管和乳小叶在结构上的退行性病变及进行性结缔组织的生长，其发病原因主要是由于内分泌激素失调。中医认为：情怀不畅，肝气不得正常疏泻而气滞血淤疾凝，冲任不调者，常有月经紊乱，面部色斑。
肝郁气滞性：月经先期或行经期乳房肿痛，随喜怒消失，一侧或双侧可扪及大小不等的串珠状节结，肿块多为绿豆大步节结，或成粗条索状。质韧不坚硬，按之可动，不与深部组织粘连，境介不清，月经周期不足，经量较多，胸闷暖气，精神抑郁，心烦易怒。
冲任不调型：乳房有肿块，经前或经期疼痛加重，经行后减轻或消失，经期多后延，经痛不剧，经量少，身倦无力，腰酸肢冷，少腹畏寒，日久失治者，少数可发生癌变
现有治疗方法中，西药有5％碘化钾，疼痛严重者可试用甲基睾丸素，在月经前一周内开始口服。中医辨证治疗一般选用中成药或方剂治疗：
(1)属肝气郁结型的，宜疏肝理气，化痰散结。可服逍遥丸、小金片、乳癖丸、犀黄丸等。
(2)属肝肾阴虚型的，宜调补肝肾，化痰散结。可服六味地黄丸、二至丸，同时合用小金丹。
(3)属冲任失调型的，宜调理冲任，温肾平肝。可服小金丹、散结灵等。
现有治疗方案多为口服药，严重的采用手术；但是对于一些特殊人群，比如哺乳期妇女，体弱者，不适合口服药；手术治疗由于其损伤太大，适合的患者类型更有限。还未见到安全有效的外用药。
发明内容
基于上述领域的需求，本发明提供一种用于乳腺病的经皮给药制品及其制备方法，用于治疗乳腺病，疗效好，无毒副作用，使用方便，及时减缓病情发展。
一种用于制备乳腺病的经皮给药制品的原料药组合物，其特征在于：包括A原料药，具有以下重量份配比：
益母草8-15，丹参8-15，当归8-15，川穹8-15，红花8-15，肉桂8-15，泽兰8-15，枳石8-15，枳壳8-15，黄莲8-15，黄柏8-15，黄芩8-15，生地8-15，山棱8-15，莪术8-15，山慈菇8-15，竹黄8-15，鱼腥草8-15，金钱草8-15，白花蛇舌草8-15，半枝莲8-15，半边莲8-15，蚤休8-15，八角金盘8-15，僵蚕8-15，地龙干8-15，生姜皮3-8，冬瓜皮3-8，桑叶3-8。
优选地，所述A原料药，具有以下任一组重量份配比：
益母草15，丹参8，当归12，川穹15，红花12，肉桂11，泽兰12，枳石8，枳壳10，黄莲15，黄柏8，黄芩15，生地12，山棱8，莪术12，山慈菇8，竹黄8，鱼腥草15，金钱草12，白花蛇舌草12，半枝莲8，半边莲15，蚤休8，八角金盘12，僵蚕12，地龙干15，生姜皮3，冬瓜皮8，桑叶5；
益母草8，丹参15，当归15，川穹8，红花15，肉桂8，泽兰15，枳石12，枳壳15，黄莲12，黄柏15，黄芩12，生地8，山棱15，莪术15，山慈菇8，竹黄13，鱼腥草12，金钱草15，白花蛇舌草8，半枝莲12，半边莲12，蚤休12，八角金盘8，僵蚕15，地龙干8，生姜皮5，冬瓜皮3，桑叶8；
益母草13，丹参12，当归8，川穹12，红花8，肉桂15，泽兰8，枳石15，枳壳12，黄莲8，黄柏12，黄芩12，生地15，山棱12，莪术8，山慈菇15，竹黄15，鱼腥草8，金钱草8，白花蛇舌草15，半枝莲15，半边莲8，蚤休15，八角金盘15，僵蚕8，地龙干12，生姜皮4，冬瓜皮4，桑叶3；
益母草10，丹参10，当归10，川穹10，红花10，肉桂10，泽兰10，枳石10，枳壳10，黄莲10，黄柏10，黄芩10，生地10，山棱10，莪术10，山慈菇10，竹黄10，鱼腥草10，金钱草10，白花蛇舌草10，半枝莲10，半边莲10，蚤休10，八角金盘10，僵蚕10，地龙干10，生姜皮5，冬瓜皮5，桑叶5。
本发明还提供一种用于乳腺病的经皮肤给药制品，其特征在于：
是以述原料药组合物的水提取液与黑木耳、羊肚菌母种原液进行共发酵，经浓缩、制备剂型所得的产物。
优选地，所述浓缩的工艺如下：
共发酵后放罐后的产物，进入醇沉提取罐，加入冷水浸提渗滤，再煮沸，滤汁去渣；其
汁加4倍体枳的75度酒精浸润，在≦30℃低温下浸制5小时，利用多糖不溶于乙醇的性质，使多糖从提取液中沉淀出来，升温至50摄氏度回收酒精后，对沉淀再进行≦55℃烘干或喷雾干燥，制得多糖粉。
优选地，所述剂型指将所述多糖粉制成丹剂、贴膏剂、涂抹剂、软膏剂、乳剂、凝胶剂或气雾剂。
优选地，所述制备剂型指制备为贴膏剂，以食用油和黄丹为辅料，制品中植物油、黄丹、多糖粉的质量比例为：14-26:4-16:14-26；优选为：25:12.5:15，20:4:20，15:10:15，14:16:14 或26:16:26，采用的水为富氢水。
本发明还提供任一所述的用于乳腺病的经皮肤给药制品的制备方法，包括如下步骤：
(1)制备所述原料药组合物的中药原液和羊肚菌母种原液；
(2)共发酵：所述中药原液稀释20倍后与羊肚菌母种原液进行共发酵得到发酵产物；
(3)浓缩干燥；
(4)制剂。
优选地，所述共发酵是指在发酵罐中，按体枳比例65-100:10-30:0.3-2：0.3-2加入所述中药原液、水、黑木耳母种原液、羊肚菌母种原液，室温下发酵到有效固体物含量达80g/L 以上时放罐；
所述浓缩的工艺：共发酵后放罐后的产物，进入醇沉提取罐，加入水浸提渗滤，再煮沸，滤汁去渣；其汁加4倍体枳的75度酒精浸润，在≦30℃低温下浸制5小时，利用多糖不溶于乙醇的性质，使多糖从提取液中沉淀出来，升温至50摄氏度回收酒精后，对沉淀再进行≦55℃烘干或喷雾干燥，制得多糖粉；
所述中药原液的提取工艺如下：在提取容器中，加入水和原料药；水与所述原料药重量比例为3-6:1，在25-35℃、800mpa环境下提取30-50分钟得到所述原料药的水提取液，优选，水与所述原料药组合物的重量比例为4-5:1，在28-32℃、800mpa环境下提取30-40分钟得到。
优选地，所述制剂指制成贴膏剂，制备步骤如下：
取植物油，猛火烧沸后，文火熬制一个半小时，油温达220-230℃，切断火源，在常温下冷却8-12小时，使油温降至40-45℃之间，加入干燥过的黄丹搅拌，然后文火边升温边搅拌，直至膏体达90℃再切断火源，不停搅拌，冷却至≦40℃时，加入多糖粉，搅拌20分钟，后倒出摊开冷却成膏状固体，然后在流动的冷水中浸泡200-240小时，其中植物油、黄丹和多糖粉的质量比例为14-26:4-16:14-26。
优选地，采用的水为富氢水。
发明人经研究，根据中医对乳腺病病因的研究，中药用药的配伍思想，在配伍出的中药原料药基础上，创造性地采用共同发酵的方法联合使用食用菌，通过发酵使得食用菌中的多糖、中药材中的植物多糖的比例大大提高，同时使中药材中其它有效成分分离出来，植物多糖和食用菌多糖经皮奏理毛孔由外而内温和地作用于乳腺组织，采用经络浸透的原理，调节乳腺内激素水平，刺激乳腺内组织，达到疏通经络、软坚散结、止痛消炎效果。根据对上百名患者跟踪调查发现，此制品安全有效，除了皮肤过敏患者不适合，无任何限制。
本发明的制品在制备过程中所用的水为富氢水，富氢水是最好的抗氧化物，集高氢量、弱碱性、负电位、小份子水为一体，容易在细胞膜穿梭参与新陈代谢，从而促进细胞排毒，增加了细胞的水合作用。使用富氢水使本发明的制品具有很强的还原功能，可以中和身体血液和细胞里的活性氧(自由基)，平衡身体酸碱度，有助于抑制乳腺内增生组织的发展
本发明的另一个主要的贡献在于，还提供了专门针对本发明的用于乳腺病的经皮肤给药制品的制备方法，采用富氢水作为溶剂，在常温、超高压(30℃、800mpa)下提取中药成分，能够最大限度地将中药材植物细胞壁内容物提取出来，并保持原有成分，其分子结构只是从大变小，从而保留药效与原料药基本一致。
本发明所述制备方法还包括膏药的制法，黑膏药是祖国医学的外治疗法，黑膏药系指药材、食用植物油与黄丹炼制成膏料，摊涂于裱背材料上，共贴敷于皮肤的外用剂型。而本发明的黑膏药，为中药材提取干燥粉剂与食用植物油熬制，低温40-50℃加入黄丹炼制而成，充分提取并保留了药材中的药效成分，具有清热解毒、扶正祛邪之功效。
本发明的一个贡献在于，采用冷油入丹加温搅拌，冷油入多糖粉。改变了用热油提取的制膏方式。有效地避免了高温入丹引起有效物质破坏及毒性物质产生，极大地发挥了本发明制品在治疗乳腺病过程中药效。同时，膏药属于外治，从而避免了内服药物的毒副作用，再加上疗效确切，受到患者欢迎。膏药中的药物直接贴敷于体表穴位上，药性透过皮毛腠理由表入里，渗透达皮下组织，一方面在局部产生药物浓度的相对优势；另一方面可通过经络的贯通运行，直达脏腑失调经气失调的病所，发挥药物“归经”和功能效应，使药效数倍提高，从而发挥最大的全省药理效应，而且不易产生耐药性，未见不良反应。
本发明的制品中采用的中药材中多种成分具有祛腐生肌，扶正祛邪的作用，采用的原料药介绍如下：
益母草：又名：蓷、茺蔚、坤草，拉丁学名：Leonurus artemisia(Laur.)S.Y.Hu F，为唇形科、益母草属植物益母草的全草，夏季开花
丹参：为唇形科植物丹参Salvia miltiorrhiza Bge.的干燥根和根茎。
当归：学名：Angelica sinensis，)别名干归、秦哪、西当归、岷当归、金当归、当归身、涵归尾、当归曲、土当归，多年生草本的根。
川穹：又称为大川芎、芎，是伞形科植物川芎的干燥根茎。
红花：为菊科植物红花Carthamus tinctorius L.的筒状花冠
肉桂：(拉丁学名：Cinnamomum cassia Presl)，又名玉桂、牡桂、玉树、大桂、辣桂、平安树、中国桂皮，为樟科植物肉桂的干燥树皮
泽兰：唇形科植物毛叶地瓜儿苗Lycopus lucidus Turcz.var.hirtus Regel的干燥地上部分
枳石：属芸香科植物酸橙及栽培变种或甜橙的干燥幼果
枳壳：药用来源为芸香科植物酸橙Citrus aurantium L.及其栽培变种的干燥未成熟果实炒熟后的薄壳。
黄莲：学名：Coptis chinensis)，多年生草本植物，喜冷凉、湿润之处，属毛莨科黄连属干燥植物根茎。
黄柏：为芸香科植物黄皮树Phellodendron chinense Schneid.的干燥树皮。
黄芩：拉丁学名：Scutellaria baicalensis Georgi)，别名山茶根、土金茶根。
生地：(拉丁学名：Rehmannia glutinosa Libosch)，别名生地黄，野地黄、山烟根等，为玄参科植物地黄的块根
山棱：又名、山棱，黑三棱科水生草本植物黑三棱SparganiumstoloniferumBuch.Ham 的干燥块茎。
莪术：别称蒁药、莪荗、青姜、黑心姜、姜黄，姜科植物蓬莪术Curcuma phaeocaulisVal.、广西莪术Curcuma Kwangsiensis S.G.Lee et C.F.Liang或温郁金Curcumawenyujin Y.H. Chen et C.Ling的干燥根茎。
山慈菇：为兰科植物杜鹃兰、独蒜兰或云南独蒜兰的干燥假鳞茎
竹黄：为肉座菌科真菌竹黄ShiraiabambusicolaP.Henn.的子座及孢子。分布于江苏、安徽、浙江、江西、福建、湖北、四川、贵州、云南等地。
鱼腥草：三白草科植物蕺菜(拉丁学名：Houttuynia cordata Thunb.)的干燥地上部分
金钱草：报春花科植物过路黄Lysimachia christinae Hance的干燥全草
白花蛇舌草：为茜草科耳草属植物白花蛇舌草的全草；学名：HedyotisdiffusaWilld.；别名：蛇舌草、蛇舌癀、蛇针草、蛇总管、二叶葎、白花十字草、尖刀草、甲猛草、龙舌草、蛇脷草、鹤舌草；功效：清热，利湿，解毒。治肺热喘咳，扁桃体炎。咽喉炎，阑尾炎，痢疾，尿路感染，黄疸，肝炎，盆腔炎，附件炎，痈肿疔疮，毒蛇咬伤，肿瘤。亦可用于消化道癌症。
半边莲：为桔梗科植物半边莲LobeliachinensisLour.的干燥全草；学名：LobeliachinensisLour.[L.radicansThunb.]；别名：细米草、急解索、半边花、蛇脷草[广东]、长虫草[河南]；功效：利尿消肿，清热解毒。用于大腹水肿，面足浮肿，痈肿疔疮，蛇虫咬伤；晚期血吸虫病腹水。
半枝莲：为唇形科植物半枝莲ScutellariabarbataDon[S.rivularisWall]的干燥全草；学名：ScytekaruabarbvataD.Don(S.riu-lariasWall.)；别名：并头草、狭叶韩信草、牙刷草、四方马兰；功效：清热解毒，化瘀利尿。用于疔疮肿毒，咽喉肿痛，毒蛇咬伤，跌扑伤痛，水肿，黄疸。
蚤休：为百合科植物七叶一枝花、金线重楼及其数种同属植物的根茎；别名：蚩休(《别录》)，重楼、重台、草甘遂(《唐本草》)，螫休(《日华子本草》)，紫河车、重楼金线(《本草图经》)，白甘遂(《小儿药证直诀》)，重台草(《圣惠方》)，独脚莲(《滇南本草》)，三层草(《纲目》)，草河车(《植物名实图考》)，九道箍、铁灯盏、七叶一盏灯、鸳鸯虫(《分类草药性》)，双层楼(《福建民间草药》)，多叶重楼、七子莲、铁灯台、枝花头(《广西中兽医药植》)，九层楼(《广西药植图志》)，螺丝七、海螺七、灯台七(《陕西中药志》)，七层塔、八角盘、孩儿掏伞(《闽东本草》)，金盘托荔枝、金盘托；功效：清热解毒，平喘止咳，熄风定惊。治痈肿，疔疮，瘰疬，喉痹，慢性气管炎，小儿惊风抽搐，蛇虫咬伤。
八角金盘：(学名：Fatsia japonica(Thunb.)Decne.et Planch)[1]乃指其掌状的叶片
僵蚕：为蚕蛾科昆虫家蚕Bombyx mori Linnaeus4～5龄的幼虫感染(或人工接种)白僵菌Beauveria bassiana(Bals.)Vuillant而致死的干燥体
地龙干：蚯蚓，曬乾加工後成為中药材
生姜皮：为姜科植物姜Zingiber officinale Rosc.的根茎外皮
冬瓜皮：为葫芦科植物冬瓜Benincasa his pida(Thunb.)Cogn.的干燥外层果皮。
桑叶：学名：Folium Mori。中药名，是桑科植物桑的干燥叶
黄丹：为纯铅经加工制造而成的四氧化三铅(PB3O4)；别名：、朱丹、红丹、漳丹、彰丹、朱粉、松丹、陶丹、铅黄、丹粉；功效：拔毒生肌，敛疮。外用治疮疡肿毒，创伤出血，烧烫伤。
羊肚菌为羊肚菌科真菌羊肚菌Morchella esculenta(L.)Pers.、小顶羊肚菌Morchella angusticeps Peck.、尖顶羊肚菌Morchella conica Pers.、粗柄羊肚菌Morchella crassipes(Vent.)Pers.、小羊肚菌Morchella deliciosa Fr.等的子实体，试管母种为其孢子体培养而来的菌丝体。
本发明的用于乳腺病的经皮肤给药制品，通过发酵，使中药中的多糖与羊肚菌菌中的多种多糖发生綴合，使本发明的药物中含有更高含量、更多种类的多糖綴合物，能够显著增强机体免疫力，经过发酵产生的丰富的多糖具有类似非特异性免疫作用，诱导机体能够主动识别体内非正常生长的细胞，有利于损伤组织/细胞的修复，并利用药物的协同或抵抗作用，以适应复杂病情的治疗要求，减少不良反应，疗效显著，安全可靠，服用简单，对乳腺病有良好的治疗效果。
临床实验统计数据显示，本发明的口服制品，对于乳腺病患者，具有显著的疗效，能及时减缓病情的发展，无毒副作用，适用者广发。
具体实施方式
以下通过具体实施例描述本发明的制品及其制备工艺。
一、材料：
黑木耳试管母种：购自中国农业微生物菌种保藏管理中心，保藏编号50007规格：试管斜面种(试管规格18mm×180mm，约40毫升)。购买到的或现有技术中记载的其它黑木耳菌株也适用本发明。申请人实验室亦有亦有保存，并制备成试管菌丝母种，自申请日起二十年可向公众发放用于实验研究。
羊肚菌(Morchella esculenta)，又名草笠竹：购自中国农业微生物菌种保藏管理中心，保藏编号51589规格：试管斜面种(试管规格18mm×180mm，约40毫升)。购买到的或现有技术中记载的其它羊肚菌菌株也适用本发明。申请人实验室亦有亦有保存，并制备成试管菌丝母种，自申请日起二十年可向公众发放用于实验研究。
中药材：益母草，丹参，当归，川穹，红花，肉桂，泽兰，枳石，枳壳，黄莲，黄柏，黄芩，生地，山棱，莪术，山慈菇，竹黄，鱼腥草，金钱草，白花蛇舌草，半枝莲，半边莲，蚤休，八角金盘，僵蚕，地龙干，生姜皮，冬瓜皮，桑叶在中药房可购买到。
植物油：麻油，也可用花生油、菜籽油、色拉油、棉籽油、葵花籽油代替。
二、富氢水：日田天领水。
三、设备：
超高压锅：DEPCOA—500,采用超高压灭菌技术(Ultra-highpressureprocessing),简称UHP；高压食品加工技术(highpressure processing)。
发酵罐：为专利号03270560.3，名称为“食用菌液体菌种培养罐的罐盖及培养罐”的实用新型专利中记载的发酵罐。
注射器：专利号200320126960.X，名称为“食用菌液体注射杆及包含该注射杆的注射器”的实用新型专利中记载的注射器。
四：准备母种液：
1)在18L富氢水中加入硫酸镁20g，磷酸氢二钾50g，磷酸二氢钾50g，蔗糖250g，淀粉250g，加富氢水定容至20L。
2)将液体培养基1注入500ml玻璃瓶内，每瓶400ml，一共得50瓶，置入手提高压锅内在0.012MP/cm2，30min，取出后冷却至28℃～34℃，放入超净工作台内,制得液体培养基。
3)将工具、器皿以及液体培养基放入超净工作台内，用30g高锰酸钾置入盛有50％福尔马林30ml的器皿中，接种用的勾、耙、针、刀放入该器皿中灭菌30min。
4)将试管母种，切成3份，每份分别接入400ml/瓶的液体培养基内，静置120min－150min。
5)在摇床上以20次/min，振荡72-96小时，镜检无杂菌，即得母种液。
实施例1.用于乳腺病的1号制品
配比好的原料药：益母草15，丹参8，当归12，川穹15，红花12，肉桂11，泽兰12，枳石8，枳壳10，黄莲15，黄柏8，黄芩15，生地12，山棱8，莪术12，山慈菇8，竹黄8，鱼腥草15，金钱草12，白花蛇舌草12，半枝莲8，半边莲15，蚤休8，八角金盘12，僵蚕 12，地龙干15，生姜皮3，冬瓜皮8，桑叶5；
步骤1.水，采用超高压锅在30℃、600mpa环境下灭活10分钟，完成后其中19升通过无菌硅胶管道注入无菌发酵罐内备用。
步骤2.提取中药的水提取液：
配比好的原料药装在100目滤网中，在超高压锅加入富氢水和配比好的原料药，重量比为4:1；
在30℃、800mpa环境下处理30分钟，提取中药原液。
步骤3:共发酵
将提取中药的中药原液80L注入步骤1准备好的已注入18升富氢水的发酵灌中。再依次注入黑木耳、羊肚菌菌的母种原液各1升进行发酵。发酵时间到为144小时，检测有效固体物，含量达80g/L以上时放罐停止发酵。
步骤4.浓缩
放罐后，进入醇沉提取罐，加入冷水浸提渗滤，再煮沸，滤汁去渣；其汁加4倍体枳的75度酒精浸润，在≦30℃低温下浸制5小时，利用多糖不溶于乙醇的性质，使多糖从提取液中沉淀出来，升温至50摄氏度回收酒精后，对沉淀再进行≦55℃烘干或喷雾干燥，制得多糖粉。
步骤5:膏状药制备工艺
取植物油，猛火烧沸后，文火熬制一个半小时，油温达220-230℃，切断火源，在常温下冷却8-12小时，使油温降至40-45℃之间，加入干燥过的黄丹搅拌，然后文火边升温边搅拌，直至膏体达90℃再切断火源，不停搅拌，冷却至≦40℃时，加入多糖粉，搅拌20分钟，后倒出摊开冷却成膏状固体，然后在流动的冷水中浸泡200-240小时，取出备用；其中植物油、黄丹和多糖粉的质量比例为25:12.5:15。
实施例2.用于乳腺病的2号制品
配比好的原料药2：益母草8，丹参15，当归15，川穹8，红花15，肉桂8，泽兰15，枳石12，枳壳15，黄莲12，黄柏15，黄芩12，生地8，山棱15，莪术15，山慈菇8，竹黄 13，鱼腥草12，金钱草15，白花蛇舌草8，半枝莲12，半边莲12，蚤休12，八角金盘8，僵蚕15，地龙干8，生姜皮5，冬瓜皮3，桑叶8；
步骤1.水，采用超高压锅在25℃、600mpa环境下灭活5分钟，完成后其中10升通过无菌硅胶管道注入无菌发酵罐内备用。
步骤2.提取中药的水提取液：
配比好的原料药装在100目滤网中，在超高压锅加入富氢水和配比好的原料药，重量比为3:1；
在25℃、800mpa环境下处理50分钟，提取中药原液。
步骤3:共发酵
将提取中药的中药原液65L注入步骤1准备好的已注入10升富氢水的发酵灌中。再依次注入黑木耳、羊肚菌菌的母种原液各0.3升进行发酵。发酵时间到为120小时，检测有效固体物，含量达80g/L以上时放罐停止发酵。
步骤4.浓缩
放罐后，进入醇沉提取罐，加入冷水浸提渗滤，再煮沸，滤汁去渣；其汁加4倍体枳的 75度酒精浸润，在≦30℃低温下浸制5小时，利用多糖不溶于乙醇的性质，使多糖从提取液中沉淀出来，升温至50摄氏度回收酒精后，对沉淀再进行≦55℃烘干或喷雾干燥，制得多糖粉。
步骤5:膏状药制备工艺
取植物油，猛火烧沸后，文火熬制一个半小时，油温达220-230℃，切断火源，在常温下冷却8-12小时，使油温降至40-45℃之间，加入干燥过的黄丹搅拌，然后文火边升温边搅拌，直至膏体达90℃再切断火源，不停搅拌，冷却至≦40℃时，加入多糖粉，搅拌20分钟，后倒出摊开冷却成膏状固体，然后在流动的冷水中浸泡200-240小时，取出备用；其中植物油、黄丹和多糖粉的质量比例为20:4:20。
实施例3.用于乳腺病的3号制品
配比好的原料药3：益母草13，丹参12，当归8，川穹12，红花8，肉桂15，泽兰8，枳石15，枳壳12，黄莲8，黄柏12，黄芩12，生地15，山棱12，莪术8，山慈菇15，竹黄 15，鱼腥草8，金钱草8，白花蛇舌草15，半枝莲15，半边莲8，蚤休15，八角金盘15，僵蚕8，地龙干12，生姜皮4，冬瓜皮4，桑叶3；
步骤1.富氢水(日田天领水)，采用超高压锅在28℃、600mpa环境下灭活7分钟，完成后其中25升通过无菌硅胶管道注入无菌发酵罐内备用。
步骤2.提取中药的水提取液：
配比好的原料药装在100目滤网中，在超高压锅加入富氢水和配比好的原料药，重量比为6:1；
在35℃、800mpa环境下处理40分钟，提取中药原液。
步骤3:共发酵
将提取中药的中药原液90L注入步骤1准备好的已注入25升富氢水的发酵灌中。再依次注入黑木耳、羊肚菌菌的母种原液各1.5升进行发酵。发酵时间到为168小时，检测有效固体物，含量达80g/L以上时放罐停止发酵。
步骤4.浓缩
放罐后，进入醇沉提取罐，加入冷水浸提渗滤，再煮沸，滤汁去渣；其汁加4倍体枳的 75度酒精浸润，在≦30℃低温下浸制5小时，利用多糖不溶于乙醇的性质，使多糖从提取液中沉淀出来，升温至50摄氏度回收酒精后，对沉淀再进行≦55℃烘干或喷雾干燥，制得多糖粉。
步骤5:膏状药制备工艺
取植物油，猛火烧沸后，文火熬制一个半小时，油温达220-230℃，切断火源，在常温下冷却8-12小时，使油温降至40-45℃之间，加入干燥过的黄丹搅拌，然后文火边升温边搅拌，直至膏体达90℃再切断火源，不停搅拌，冷却至≦40℃时，加入多糖粉，搅拌20分钟，后倒出摊开冷却成膏状固体，然后在流动的冷水中浸泡240小时，取出备用；其中植物油、黄丹和多糖粉的质量比例为15:10:15。
实施例4.用于乳腺病的4号制品
配比好的原料药4：益母草10，丹参10，当归10，川穹10，红花10，肉桂10，泽兰 10，枳石10，枳壳10，黄莲10，黄柏10，黄芩10，生地10，山棱10，莪术10，山慈菇10，竹黄10，鱼腥草10，金钱草10，白花蛇舌草10，半枝莲10，半边莲10，蚤休10，八角金盘10，僵蚕10，地龙干10，生姜皮5，冬瓜皮5，桑叶5；
步骤1.富氢水(日田天领水)，采用超高压锅在32℃、600mpa环境下灭活30分钟，完成后其中30升通过无菌硅胶管道注入无菌发酵罐内备用。
步骤2.提取中药的水提取液：
配比好的原料药装在100目滤网中，在超高压锅加入富氢水和配比好的原料药，重量比为5:1；
在28℃、800mpa环境下处理45分钟，提取中药原液。
步骤3:共发酵
将提取中药的中药原液100L注入步骤1准备好的已注入30升富氢水的发酵灌中。再依次注入黑木耳、羊肚菌菌的母种原液各2升进行发酵。发酵时间到为132小时，检测有效固体物，含量达80g/L以上时放罐停止发酵。
步骤4.浓缩
放罐后，进入醇沉提取罐，加入冷水浸提渗滤，再煮沸，滤汁去渣；其汁加4倍体枳的 75度酒精浸润，在≦30℃低温下浸制5小时，利用多糖不溶于乙醇的性质，使多糖从提取液中沉淀出来，升温至50摄氏度回收酒精后，对沉淀再进行≦55℃烘干或喷雾干燥，制得多糖粉。
步骤5.膏状药制备工艺
取植物油，猛火烧沸后，文火熬制一个半小时，油温达220-230℃，切断火源，在常温下冷却8-12小时，使油温降至40-45℃之间，加入干燥过的黄丹搅拌，然后文火边升温边搅拌，直至膏体达90℃再切断火源，不停搅拌，冷却至≦40℃时，加入多糖粉，搅拌20分钟，后倒出摊开冷却成膏状固体，然后在流动的冷水中浸泡240小时，取出备用；其中植物油、黄丹和多糖粉的质量比例为14:16:14。
实施例5.用于乳腺病的5号制品
配比好的原料药5：益母草10，丹参10，当归10，川穹10，红花10，肉桂10，泽兰10，枳石10，枳壳10，黄莲10，黄柏10，黄芩10，生地10，山棱10，莪术10，山慈菇10，竹黄10，鱼腥草10，金钱草10，白花蛇舌草10，半枝莲10，半边莲10，蚤休10，八角金盘 10，僵蚕10，地龙干10，生姜皮5，冬瓜皮5，桑叶5。
步骤1.富氢水(日田天领水)，采用超高压锅在35℃、600mpa环境下灭活15分钟，完成后其中15升通过无菌硅胶管道注入无菌发酵罐内备用。
步骤2.提取中药的水提取液
配比好的原料药装在100目滤网中，在超高压锅加入富氢水和配比好的原料药，重量比为4.5:1；
在32℃、800mpa环境下处理35分钟，提取中药原液。
步骤3:共发酵
将提取中药的中药原液70L注入步骤1准备好的已注入15升富氢水的发酵灌中。再依次注入黑木耳、羊肚菌菌的母种原液各0.5升进行发酵。发酵时间到为156小时，检测有效固体物，含量达80g/L以上时放罐停止发酵。
步骤4.浓缩
放罐后，进入醇沉提取罐，加入冷水浸提渗滤，再煮沸，滤汁去渣；其汁加4倍体枳的 75度酒精浸润，在≦30℃低温下浸制5小时，利用多糖不溶于乙醇的性质，使多糖从提取液中沉淀出来，升温至50摄氏度回收酒精后，对沉淀再进行≦55℃烘干或喷雾干燥，制得多糖粉。
步骤5.膏状药制备工艺
取植物油，猛火烧沸后，文火熬制一个半小时，油温达220-230℃，切断火源，在常温下冷却8-12小时，使油温降至40-45℃之间，加入干燥过的黄丹搅拌，然后文火边升温边搅拌，直至膏体达90℃再切断火源，不停搅拌，冷却至≦40℃时，加入多糖粉，搅拌20分钟，后倒出摊开冷却成膏状固体，然后在流动的冷水中浸泡240小时，取出备用；其中植物油、黄丹和多糖粉的质量比例为26:16:26
使用方法：加温至45℃若成流状时摊在布上，贴在患者乳房疼痛区域，黑膏药面覆盖整个区域。每帖贴10天，中途洗澡时揭下，洗完加热再贴。
临床疗效观察试验例
共106例,年龄30～52岁，病史最长10年，最短两月；
诊断标准：
体征：乳房疼痛、乳房肿块、乳头溢液、月经失调；
经超声检测提示符合乳腺性增生超声表现；钼靶检测排除乳腺癌。
连续三个疗程，即30天后，效果观察：
疗效标准：
(1)临床治愈：肿块消失、乳痛消失，停药后3个月不复发。
(2)显效：肿块最大直径缩小1/2以上，乳痛消失。
(3)有效：①肿块最大直径缩小不足1/2，乳痛减轻；②肿块缩小1/2以上，乳痛不减轻。
(4)无效：①肿块不缩小，或反而增大变硬者；②单纯乳痛缓解，而肿块不缩小。
治愈：71例；半年后随访无复发。从体征上可观察到气色健康，自述内分泌回归正常，心情愉悦。
显效：19例；持续再用3个疗程后，半年后随访肿块无发展。从体征上可观察到气色健康，自述内分泌回归正常，心情愉悦。
有效：11例；持续再用3个疗程后，达到显效的程度，半年后随防肿块无发展。从体征上可观察到气色有改善，自述内分泌月经较之前更为规律正常，心情愉悦。
无效：4例，(由于皮肤敏感，对本发明的制品中某些成分过敏而无法持续使用)
总有效率：96％，治愈率67.6％。
Claims (10)
1.一种用于制备乳腺病的经皮给药制品的原料药组合物，其特征在于：包括A原料药，具有以下重量份配比：
益母草8-15，丹参8-15，当归8-15，川穹8-15，红花8-15，肉桂8-15，泽兰8-15，枳石8-15，枳壳8-15，黄莲8-15，黄柏8-15，黄芩8-15，生地8-15，山棱8-15，莪术8-15，山慈菇8-15，竹黄8-15，鱼腥草8-15，金钱草8-15，白花蛇舌草8-15，半枝莲8-15，半边莲8-15，蚤休8-15，八角金盘8-15，僵蚕8-15，地龙干8-15，生姜皮3-8，冬瓜皮3-8，桑叶3-8。
2.根据权利要求2所述的组合物，特征在于：所述A原料药，具有以下任一组重量份配比：
益母草15，丹参8，当归12，川穹15，红花12，肉桂11，泽兰12，枳石8，枳壳10，黄莲15，黄柏8，黄芩15，生地12，山棱8，莪术12，山慈菇8，竹黄8，鱼腥草15，金钱草12，白花蛇舌草12，半枝莲8，半边莲15，蚤休8，八角金盘12，僵蚕12，地龙干15，生姜皮3，冬瓜皮8，桑叶5；
益母草8，丹参15，当归15，川穹8，红花15，肉桂8，泽兰15，枳石12，枳壳15，黄莲12，黄柏15，黄芩12，生地8，山棱15，莪术15，山慈菇8，竹黄13，鱼腥草12，金钱草15，白花蛇舌草8，半枝莲12，半边莲12，蚤休12，八角金盘8，僵蚕15，地龙干8，生姜皮5，冬瓜皮3，桑叶8；
益母草13，丹参12，当归8，川穹12，红花8，肉桂15，泽兰8，枳石15，枳壳12，黄莲8，黄柏12，黄芩12，生地15，山棱12，莪术8，山慈菇15，竹黄15，鱼腥草8，金钱草8，白花蛇舌草15，半枝莲15，半边莲8，蚤休15，八角金盘15，僵蚕8，地龙干12，生姜皮4，冬瓜皮4，桑叶3；
益母草10，丹参10，当归10，川穹10，红花10，肉桂10，泽兰10，枳石10，枳壳10，黄莲10，黄柏10，黄芩10，生地10，山棱10，莪术10，山慈菇10，竹黄10，鱼腥草10，金钱草10，白花蛇舌草10，半枝莲10，半边莲10，蚤休10，八角金盘10，僵蚕10，地龙干10，生姜皮5，冬瓜皮5，桑叶5。
3.一种用于乳腺病的经皮肤给药制品，其特征在于：
是以权利要求1或2所述的原料药组合物的水提取液与黑木耳、羊肚菌母种原液进行共发酵，经浓缩、制备剂型所得的产物。
4.根据权利要求3所述的经皮肤给药制品，其特征在于，所述浓缩的工艺如下：
共发酵后放罐后的产物，进入醇沉提取罐，加入冷水浸提渗滤，再煮沸，滤汁去渣；其汁加4倍体枳的75度酒精浸润，在≦30℃低温下浸制5小时，利用多糖不溶于乙醇的性质，使多糖从提取液中沉淀出来，升温至50摄氏度回收酒精后，对沉淀再进行≦55℃烘干或喷雾干燥，制得多糖粉。
5.根据权利要求3或4所述的制品，其特征在于，所述剂型指将所述多糖粉制成丹剂、贴膏剂、涂抹剂、软膏剂、乳剂、凝胶剂或气雾剂。
6.根据权利要求5所述的制品，其特征在于，所述制备剂型指制备为贴膏剂，以食用油和黄丹为辅料，制品中植物油、黄丹、多糖粉的质量比例为：14-26:4-16:14-26；优选为：25:12.5:15，20:4:20，15:10:15，14:16:14或26:16:26，采用的水为富氢水。
7.权利要求3-6任一所述的用于乳腺病的经皮肤给药制品的制备方法，包括如下步骤：
(1)制备所述原料药组合物的中药原液和羊肚菌母种原液；
(2)共发酵：所述中药原液稀释20倍后与羊肚菌母种原液进行共发酵得到发酵产物；
(3)浓缩干燥；
(4)制剂。
8.根据权利要求7所述的制备方法，其特征在于：
所述共发酵是指在发酵罐中，按体枳比例65-100:10-30:0.3-2：0.3-2加入所述中药原液、水、黑木耳母种原液、羊肚菌母种原液，室温下发酵到有效固体物含量达80g/L以上时放罐；
所述浓缩的工艺：共发酵后放罐后的产物，进入醇沉提取罐，加入水浸提渗滤，再煮沸，滤汁去渣；其汁加4倍体枳的75度酒精浸润，在≦30℃低温下浸制5小时，利用多糖不溶于乙醇的性质，使多糖从提取液中沉淀出来，升温至50摄氏度回收酒精后，对沉淀再进行≦55℃烘干或喷雾干燥，制得多糖粉；
所述中药原液的提取工艺如下：在提取容器中，加入水和原料药；水与所述原料药重量比例为3-6:1，在25-35℃、800mpa环境下提取30-50分钟得到所述原料药的水提取液，优选，水与所述原料药组合物的重量比例为4-5:1，在28-32℃、800mpa环境下提取30-40分钟得到。
9.根据权利要求7或8所述的制备方法，所述制剂指制成贴膏剂，制备步骤如下：
取植物油，猛火烧沸后，文火熬制一个半小时，油温达220-230℃，切断火源，在常温下冷却8-12小时，使油温降至40-45℃之间，加入干燥过的黄丹搅拌，然后文火边升温边搅拌，直至膏体达90℃再切断火源，不停搅拌，冷却至≦40℃时，加入多糖粉，搅拌20分钟，后倒出摊开冷却成膏状固体，然后在流动的冷水中浸泡200-240小时，其中植物油、黄丹和多糖粉的质量比例为14-26:4-16:14-26。
10.根据权利要求7-9任一所述的方法，其特征在于，采用的水为富氢水。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711176595.6A CN107670016A (zh) | 2017-11-22 | 2017-11-22 | 一种用于乳腺病的经皮肤给药制品及其制备方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711176595.6A CN107670016A (zh) | 2017-11-22 | 2017-11-22 | 一种用于乳腺病的经皮肤给药制品及其制备方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107670016A true CN107670016A (zh) | 2018-02-09 |
Family
ID=61149800
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711176595.6A Pending CN107670016A (zh) | 2017-11-22 | 2017-11-22 | 一种用于乳腺病的经皮肤给药制品及其制备方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107670016A (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT201900005940A1 (it) * | 2019-04-17 | 2020-10-17 | Shanghai Boling Man Cosmetic Co Ltd | Preparato per pediluvio e suo procedimento di preparazione |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105456923A (zh) * | 2015-12-16 | 2016-04-06 | 王升强 | 一种祛瘀止痛的中药组合物及其制备方法 |
| CN107198762A (zh) * | 2017-05-31 | 2017-09-26 | 华子昂 | 一种具有治疗乳腺疾病的薄贴及其制备方法 |
-
2017
- 2017-11-22 CN CN201711176595.6A patent/CN107670016A/zh active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105456923A (zh) * | 2015-12-16 | 2016-04-06 | 王升强 | 一种祛瘀止痛的中药组合物及其制备方法 |
| CN107198762A (zh) * | 2017-05-31 | 2017-09-26 | 华子昂 | 一种具有治疗乳腺疾病的薄贴及其制备方法 |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT201900005940A1 (it) * | 2019-04-17 | 2020-10-17 | Shanghai Boling Man Cosmetic Co Ltd | Preparato per pediluvio e suo procedimento di preparazione |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102078486B (zh) | 一种祛黄褐斑的药物组合物及其制备方法 | |
| CN105920194A (zh) | 一种抗肿瘤的中药药剂 | |
| CN106310120A (zh) | 一种广普型中药组合物水剂及其制备方法 | |
| CN102631538B (zh) | 一种治疗心脏病的中药 | |
| CN103783508A (zh) | 一种苦荞美容祛斑口服液及其制备方法 | |
| CN107670016A (zh) | 一种用于乳腺病的经皮肤给药制品及其制备方法 | |
| CN105412697A (zh) | 一种清热除湿、保肝利胆的佩兰口服液及其制备方法 | |
| CN104906366A (zh) | 一种治疗月经后期的药物制剂 | |
| CN104998197A (zh) | 一种用于治疗肝癌的中药组合物 | |
| CN104056242A (zh) | 一种治疗急性胆囊炎的中药组合物及其制备方法 | |
| CN107261032A (zh) | 治疗心肌缺血的中药组合物及其制备方法 | |
| CN103099885A (zh) | 具有祛痤疮功能软胶囊及其制备方法 | |
| CN105920130A (zh) | 治疗足跟痛的中药制备方法及其外用膏剂 | |
| CN109646665A (zh) | 杜仲清肺抗癌固体茶及其制备方法 | |
| CN115998828B (zh) | 一种治疗乳腺增生的中药组合物及其制备方法 | |
| CN104491717B (zh) | 一种治疗乳腺增生的药物 | |
| CN107693752A (zh) | 一种用于银屑病的口服制品与制备方法 | |
| CN106806842A (zh) | 一种治疗乳腺增生结节的中药组合物及其制备方法 | |
| CN106266971A (zh) | 一种用于治疗乳腺增生的药物制剂 | |
| CN105213888A (zh) | 一种除湿排毒减肥的夏枯草口服液及其制备方法 | |
| CN105288316A (zh) | 一种清热除湿、保肝利胆的牛筋草口服液及其制备方法 | |
| CN107669872A (zh) | 一种用于子宫肿瘤的经皮肤给药制品及其制备方法 | |
| CN104274697A (zh) | 玉竹养生中药酒及制备方法 | |
| CN107890504A (zh) | 一种用于肝癌的经皮给药制品与制备方法 | |
| CN113082142A (zh) | 一种疏肝行气中药乳贴 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180209 |
|
| RJ01 | Rejection of invention patent application after publication |