CN107669872A - It is a kind of for cervix tumor through percutaneous drug delivery product and preparation method thereof - Google Patents

It is a kind of for cervix tumor through percutaneous drug delivery product and preparation method thereof Download PDF

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Publication number
CN107669872A
CN107669872A CN201711175431.1A CN201711175431A CN107669872A CN 107669872 A CN107669872 A CN 107669872A CN 201711175431 A CN201711175431 A CN 201711175431A CN 107669872 A CN107669872 A CN 107669872A
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chinese
preparation
product
polysaccharide
saltcake
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彭鹏
李泽文
郑永琴
彭都
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Zhongshan City Selection Biological Technology Co Ltd
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Zhongshan City Selection Biological Technology Co Ltd
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Abstract

The present invention " a kind of for cervix tumor through percutaneous drug delivery product and preparation method thereof ", belongs to tcm field, is the aqueous extract of following bulk drug and morchella mother culture stoste carries out product obtained by common fermentation；The bulk drug has following weight：Chinese tallow tree root 90 110, rheum officinale 70 90, saltcake 70 90, crotons 20 40, trade route 20 40, WUHUASHE 28, poisonless snake 28, long-nosed pit viper 28, centipede 28, scorpion 28, flea stops 28, oldenlandia diffusa 28, goldenrod 28, Chinese lobelia 28, Sculellaria barbata 28, Nanling Yao spend 28；The aqueous extract of the bulk drug is to use hydrogen rich water as Extraction solvent.The product is used to treat cervix tumor, good effect, has no toxic side effect, easy to use, slows down disease development in time.

Description

It is a kind of for cervix tumor through percutaneous drug delivery product and preparation method thereof
Technical field
The present invention relates to traditional Chinese medical science product and its process technology, more particularly to it is a kind of for cervix tumor through percutaneous drug delivery Product and preparation method thereof.
Technical background
Cervix tumor refer to occur inside uterus and cervical canal benign or malignant tumour, be the most common tumour of women One of, most commonly seen is fibroid, carcinoma of endometrium and cervix cancer.The traditional Chinese medical science thinks that cervix tumor is mostly the cloudy gas of liver kidney It is impaired, the interior gas of liver kidney is produced yang-energy, form the pathogenic QI in the body of cervix tumor, and generate cervix tumor.
The treatment method of cervix tumor is mainly operation, chemicotherapy, traditional Chinese medicine at present.In early stage, cervix tumor can lead to Cross the purpose that operation reaches healing with reference to the method for Chinese medicine；But the late period of cervix tumor is arrived, operation method is very Difficulty reaches the purpose of healing, can only be treated by chemicotherapy or merely with traditional Chinese medicine.Chemicotherapy has certain secondary work to body With, it is impossible to cancer cell is all killed, can only proportionally kill cancer cell, residual cancer cells are low in immunity in poor health In the case of develop quickly, form new focus；Traditional Chinese medicine can strengthen the body resistance to consolidate the constitution, and improve the immunologic function of patient, promote body Self-healing ability, recover various functions, there is the effect of righting, anticancer, toxin expelling, change knurl, reach the therapeutic effect treated both principal and secondary aspect of disease.Have Necessity research and development have the Chinese medicine external product of special curative effect to cervix tumor.
The content of the invention
Based on the demand in above-mentioned field, the present invention provides a kind of for the percutaneous dosing product of cervix tumor and its preparation side Method, for treating cervix tumor, good effect, have no toxic side effect, it is easy to use, slow down disease development in time, improve patient and be immunized Power, significantly improve life in patients.
A kind of raw material drug composition for being used to prepare cervix tumor percutaneous dosing product, it is characterised in that：Including A raw materials Medicine, there is following weight：
Chinese tallow tree root 90-110, rheum officinale 70-90, saltcake 70-90, crotons 20-40, trade route 20-40, WUHUASHE 2-8, poisonless snake 2-8, long-nosed pit viper 2-8, centipede 2-8, scorpion 2-8, flea stop 2-8, oldenlandia diffusa 2-8, goldenrod 2-8, Chinese lobelia 2-8, half Lotus 2-8, Nanling Yao spend 2-8.
Preferably, in described composition, the A bulk drugs have following any group of weight：
Chinese tallow tree root 100, rheum officinale 80, saltcake 80, crotons 30, trade route 30, WUHUASHE 5, poisonless snake 5, long-nosed pit viper 5, centipede 5, scorpion Son 5, flea stop 5, oldenlandia diffusa 5, goldenrod 5, Chinese lobelia 5, Sculellaria barbata 5, and Nanling Yao spends 5；
Chinese tallow tree root 90, rheum officinale 89, saltcake 70, crotons 38, trade route 40, WUHUASHE 3, poisonless snake 8, long-nosed pit viper 3, centipede 2, scorpion 7, flea stops 2, oldenlandia diffusa 7, goldenrod 8, Chinese lobelia 3, Sculellaria barbata 2, and Nanling Yao spends 7；
Chinese tallow tree root 108, rheum officinale 90, saltcake 73, crotons 40, trade route 22, WUHUASHE 8, poisonless snake 3, long-nosed pit viper 2, centipede 7, scorpion Son 8, flea stop 3, oldenlandia diffusa 2, goldenrod 7, Chinese lobelia 8, Sculellaria barbata 3, and Nanling Yao spends 2；
Chinese tallow tree root 110, rheum officinale 73, saltcake 90, crotons 22, trade route 20, WUHUASHE 7, poisonless snake 2, long-nosed pit viper 7, centipede 8, scorpion Son 3, flea stop 8, oldenlandia diffusa 3, goldenrod 2, Chinese lobelia 7, Sculellaria barbata 8, and Nanling Yao spends 3；
Chinese tallow tree root 92, rheum officinale 70, saltcake 89, crotons 20, trade route 38, WUHUASHE 2, poisonless snake 7, long-nosed pit viper 8, centipede 3, scorpion 2, flea stops 7, oldenlandia diffusa 8, goldenrod 3, Chinese lobelia 2, Sculellaria barbata 7, and Nanling Yao spends 8.
Another aspect of the present invention, disclose it is a kind of for cervix tumor through percutaneous drug delivery product, it is characterised in that：
It is that aqueous extract and the morchella mother culture stoste of above-mentioned raw materials drug composition carries out common fermentation, it is concentrated, prepare agent Product obtained by type.
In some of the invention through in percutaneous drug delivery product, it is characterised in that the technique of its concentration used is as follows：
The product after tank is put after common fermentation, into alcohol precipitation extractor, adds cold water extraction diafiltration, then is boiled, filtered juice removes slag； Its juice adds 75 degree of alcohol of 4 times of volumes to infiltrate to be soaked 5 hours under the low temperature of , ≤30 DEG C, using property of the polysaccharide insoluble in ethanol, Polysaccharide is set to be precipitated out from extract solution, after being warming up to 50 degrees Celsius of recovered alcohols, to the drying of precipitation Zai Jin Hang≤55 DEG C or spray Mist is dried, and polysaccharide powder is made.
In some of the invention through in percutaneous drug delivery product, it is characterised in that the formulation refers to, and the polysaccharide powder is made Sublimed preparation, emplastrum, liniment, ointment, emulsion, gel or aerosol.
In some of the invention through in percutaneous drug delivery product, it is characterised in that the preparation formulation, which refers to, is prepared as emplastrum, Using edible oil and yellow lead as auxiliary material, edible oil, yellow lead, the mass ratio of polysaccharide powder are in product：14-26:4-16:14-26；It is excellent Elect as：25:12.5:15,20:4:20,15:10:15,14:16:14 or 26:16:26, the water used is hydrogen rich water.
Another aspect of the present invention, it is to disclose the preparation method through percutaneous drug delivery product for cervix tumor, wraps Include following steps：
(1) Chinese medicine stoste and morchella mother culture stoste of the raw material drug composition are prepared；
(2) common fermentation：The Chinese medicine stoste carries out common fermentation with morchella mother culture stoste after diluting 20 times and obtains fermentation production Thing；
(3) it is concentrated and dried
(4) preparation.
In some preparation methods that the present invention is implemented, the technique of the concentration is as follows：
The common fermentation refers in fermentation tank, by volume example 65-100:10-30:It is former that 0.3-2 adds the Chinese medicine Liquid, water, morchella mother culture stoste, tank is put when fermentation reaches more than 80g/L to effective solid contents at room temperature；
The technique of the concentration：The product after tank is put after common fermentation, into alcohol precipitation extractor, adds flooding diafiltration, then Boil, filtered juice removes slag；Its juice adds 75 degree of alcohol of 4 times of volumes to infiltrate to be soaked 5 hours under the low temperature of , ≤30 DEG C, using polysaccharide not The property of ethanol is dissolved in, polysaccharide is precipitated out from extract solution, after being warming up to 50 degrees Celsius of recovered alcohols, precipitation is carried out again ≤ 55 DEG C of drying or spray drying, are made polysaccharide powder,
The extraction process of the Chinese medicine stoste is as follows：In extraction vessel, water and bulk drug are added；Water and the bulk drug Part by weight is 3-6:1, under 25-35 DEG C, 800mpa environment extract 30-50 minutes obtain the aqueous extract of the bulk drug, It is preferred that the part by weight of water and the raw material drug composition is 4-5:1,30-40 points are extracted under 28-32 DEG C, 800mpa environment Clock obtains.
In some preparation methods that the present invention is implemented, the preparation, which refers to, is made emplastrum, and preparation process is as follows：
After taking vegetable oil, vigorous fire to boil, slow fire boils one and a half hours, and oil temperature reaches 220-230 DEG C, burning things which may cause a fire disaster is cut off, normal Temperature lower cooling 8-12 hours, oil temperature is down between 40-45 DEG C, add dried yellow lead stirring, then slow fire is in heating Stirring, until lotion cuts off burning things which may cause a fire disaster again up to 90 DEG C, do not stop to stir, during Leng Que Zhi≤40 DEG C, add polysaccharide powder, stir 20 minutes, After pour out to spread out and be cooled to cream solid, then soaked in the cold water of flowing 200-240 hours, wherein vegetable oil, yellow lead and The mass ratio of polysaccharide powder is 14-26:4-16:14-26.
In some preferred preparation methods that the present invention is implemented：The water used is hydrogen rich water.
Inventor is by conscientiously studying, according to research of the traditional Chinese medical science to uterus tumor etiology, the compatibility thought of Chinese medicine medication, On the basis of the Chinese medicine material medicine that compatibility goes out, edible mushroom is creatively used in combination using the method for co-fermentation, made by fermentation The polysaccharide in edible mushroom, the ratio of the plant polyose in Chinese medicine greatly improve, while make other active ingredients in Chinese medicine Separate, plant polyose and edible fungi polysaccharide collaboration leniently act on patients immune system, make patients immune system gradual Normal level is returned to, promotes immune system to recover the identification to cancer cell and attacking ability, so as to suppress the development of cancer cell； Plant/edible fungi polysaccharide additionally aids the reparation of injury tissue/cell.
The product of present invention water used in preparation process is hydrogen rich water, and hydrogen rich water is best polyphenoils, and collection is high Hydrogen amount, alkalescent, negative potential, small one's share of expenses for a joint undertaking water are integrated, and easily being shuttled in cell membrane participates in metabolism, so as to promote cell to arrange Poison, add the aquation of cell.The product for making the present invention using hydrogen rich water has very strong restoring function, can neutralize body Active oxygen (free radical) in body blood and cell, body acid-base value is balanced, help to suppress the development of cancer cell, and can be effective Alleviate or prevent multiple complications.
Another main contribution of the present invention is, additionally provides the warp for cervix tumor specifically for the present invention The preparation method of percutaneous drug delivery product, using hydrogen rich water as solvent, in being extracted under normal temperature, super-pressure (30 DEG C, 800mpa) Medicine composition, Chinese medicine plant cell wall content can be extracted to greatest extent, and keep original composition, its molecule knot Structure is basically identical with bulk drug so as to retain drug effect simply from diminishing greatly.
Preparation method of the present invention also includes the preparation method of plaster, and black plaster is the external therapy of motherland's medical science, black plaster Mean that medicinal material, edible vegetable oil and yellow lead refining into creme, spread onto in framed back material, are pasted on the exterior-applied formulation of skin altogether. And the black plaster of the present invention, dry pulvis for Chinese medicine extraction boils with edible vegetable oil, and 40-50 DEG C of low temperature adds yellow lead refining Form, fully extract and remain the effective component in medicinal material, there is the effect of clearing heat and detoxicating, strengthening vital QI to eliminate pathogenic factors, in the basin of women Medication can promote withered cell and small molecule to excrete in vitro in chamber and vagina.
The contribution of the present invention is, enters red heating stirring using cold oil, cold oil enters polysaccharide powder.Change and carried with deep fat The herbal paste formula processed taken.Efficiently avoid high temperature enter pellet cause active principle destroy and toxicant produce, greatly play Inventive article drug effect during cervix tumor is treated.It is secondary so as to avoid the poison of endo-medicine meanwhile plaster belongs to outer and controlled Effect, along with curative for effect, welcome by patient.Medicine in plaster is directly pasted on body surface point, and the property of medicine passes through skin Hair space between skin and muscles is fromed superficies to interior, and infiltration reaches hypodermis, is on the one hand locally producing the relative advantage of drug concentration；On the other hand can lead to The insertion operation of channels and collaterals is crossed, the sick institute that through zang-fu disharmony is lacked of proper care through gas, medicine " channel tropism " and functional effect is played, makes drug effect number Improve again, so as to play the whole province's pharmacodynamics effect of maximum, and be not likely to produce drug resistance, have no adverse reaction.
Multiple components have putrefaction-removing granulation-promoting in the Chinese medicine used in the product of the present invention, the effect of strengthening vital QI to eliminate pathogenic factors, use Bulk drug pharmacology it is as follows：
Yellow lead：For the processed lead orthoplumbate (PB3O4) being fabricated of pure lead；Alias：, it is Zhu Dan, red lead, Zhang Dan, evident Pellet, Zhu Fen, Song Dan, Tao Dan, lead and yellow-collation, red powder；Effect：Removing toxic substances and promoting tissue regeneration, sore.Sore swollen toxin is controlled in external application, traumatic bleeding, is burnt and is scalded Wound.
Radix Sapii Discoloris：CORTEX SAPII RADICIS is the root skin and bark of euphorbia plant Chinese tallow tree, cures mainly bilharziasis, hepatic sclerosis abdomen Water, stool and urine is unfavorable, venomous snake bite；External application cures mainly furunculosis, corn, mastitis, traumatic injury, eczema, dermatitis.
Rheum officinale：For polygonum rheum palmatum RheumpalmatumL., Rheum tanguticum Maxim RheumtanguticumMaxim.exBalf.Or Rheum officinale RheumofficinaleBaill.Drying root and rhizome；Not Name：Fragrant rheum officinale, R.hoofshaped, general, raw army；Effect：Purge heat logical intestines, removing pattogenic heat from the blood and toxic material from the body, dispelling stasis of blood and stimulating the menstrual flow.For real heat constipation, stagnate Stomachache, rush down dysentery is not well, jaundice with damp-heat pathogen, blood-head tells nosebleed, hot eyes, pharynx swelling, abdominalgia with intestinal abscess, carbuncle swells furunculosis, blood stasis closed, bruise damage Wound, controls scald outside；UGB.Prepared RADIX ET RHIZOMA RHEI with wine is apt to clear part of the body cavity above the diaphragm housing the heart and lungs noxious heat in the blood system.For hot eyes pharynx swelling, gingivitis.It is ripe Rheum officinale, which rushes down, exerts oneself to delay, purging intense heat and detonicating.For pathogenic fire,toxin and furuncles.Charred RADIX ET RHIZOMA RHEI cooling blood and removing stasis stops blooding.There is stasis of blood haemorrhage for blood-head.
Saltcake：For Sulfates mineral saltcake race saltcake, the processed refined crystalline solid formed；Alias：Basin disappear (《Book on Chinese herbal medicine Figure warp》), saltcake (《Medicine origin》)；Effect：Purgating heat and bowels, moistening for dryness and softening hard mass, detumescence of relieving inflammation or internal heat.It is dry for real heat constipation, stool Knot, stagnate stomachache, acute appendicitis swelling and pain；Control acute mastitis, hemorrhoid gall outside.
Crotons：For euphorbia plant crotons CrotontigliumL.Dry mature fruit, root and leaf also hyoscine；Learn Name：CrotontigliumL.；Alias：Eyes dragon, great Ye eyes dragon, Jiang Zi, sudden dive tree, 800 power, awns；Effect：Seed： Dispelled under rushing down product, detumescence of relieving oedema or abdominal distension through diuresis or purgation.Stagnated for cold product, fullness and oppression of chest and abdomen；Blister is lost in external application.For malignant sore mange, wart mole, diphtheria, malaria, Intestinal obstruction.Root：Warming spleen and stomach for dispelling cold, dispelling, collateral-activating.For rheumatic arthritis, treating swelling and pain by traumatic injury, venomous snake bite.Leaf：External application treating chilblain, And can infanticide Jue, fly maggot.
Trade route：For the root of herbaceos perennial Phytolacca acinosa；Scientific name：Radix phytolaccae；Effect：Eliminating the phlegm, relieving asthma, Antibechic, antibacterial, anti-inflammatory, diuresis.Harness the river swollen, turgor, tinea pedis, larynx numbness, carbuncle swells, malignant sore.
WUHUASHE：It is commonly called as long-noded pit viper and is also known as Bungarus multicinctus, Bungarus Parvus, there is wind-dispelling, dredging collateral, only the effect of convulsion.
Poisonless snake：For the entirety of Colubridae animal dinodon rufozonatum snake；Scientific name：Dinodonrufozonatum(Cantor)；Alias： Red chain (Tao Hongjing), red chinaberry snake, mulberry root snake (《Detailed outline》), the red refining of fire (freezes justice《Zoology》), fire practices snake (Bi De Yu《System is moved Thing》), fiery dinodon rufozonatum snake (《Vertebrate systematics》), erythema snake (《Biology is circulated a notice of》(2)：8,1958)；Effect：Control chronic Fistula and ulcer.
Long-nosed pit viper：For Viperidae animal long-noded pit viper Agkisrrodon acutus (Guenther) hirudo leech；Scientific name：；Alias： Big White Flower snake, chessboard snake, long-noded pit viper, Hundred-pace pit viper；Effect：Wind-dispelling, dredging collateral, only convulsion.For rheumatoid arthritis stubborn, numbness contracture, apoplexy Facial paralysis, hemiplegia, spasm of twitching, lockjaw, leprosy mange.
Centipede：For Scolopendridae animal Scolopendpa Subspinipes Mutilans L. KOCH ScolopendrasubspinipesmutilansL.Koch drying Body；Scientific name：ScolopendrasubspinipesmutilansL.Koch；Alias：Centipede, thousand-legger, golden head centipede, hundred Pin；Effect：Ceases wind antispastic, work(poison dissipating bind, removes obstruction in channels to relieve pain.For child convulsion, spasm of twitching, middle air port is askew, hemiplegia, breaks Cold, rheumatoid arthritis stubborn, sore, scrofula, venomous snake bite.
Scorpio：It is all for drying for Buthidae buthus martensii Karscs；Alias：Scorpion；Effect：Antispastic, analgesic, removing toxic substances.
Flea stops：For the rhizome of liliaceous plant paris polyphylla, RHIZOMA PARIDIS and its several congeners；Alias：Chi stops (《Do not record》), Paris polyphylla, Chong Tai, the careless root of gansui (《Tang materia medica》), sting not (《Japan hanako materia medica》), dried human placenta, Paris polyphylla gold thread (《Book on Chinese herbal medicine Figure warp》), the white root of gansui (《Key to therapeutic of children's disease》), weight platform grass (《Peaceful holy benevolent prescription》), Typhonium divaricatum(L.) Decne (《The southern regions of the Yunnan Province book on Chinese herbal medicine》), three layers of grass (《Guiding principle Mesh》), careless river car (《The Illustrated Book on Plants》), nine hoops, iron oil lamp, seven leaves, one lamp, mandarin duck worm (《Classify herbal》), it is double Floor (《Fujian traditional herbal medicine》), Paris polyphylla, Qi Zilian, Rhizoma Paridis, branch fresh idea (《Guangxi Chinese veterinarian's medicine is planted》), nine floors (《Guangxi medicine plants figure will》), Calanthe davidii Franhc, conch seven, lamp stand seven (《Shaanxi Chinese medicinal herbal》), seven layers of tower, anistree disk, my child draw umbrella (《Fujian east book on Chinese herbal medicine》), golden pan arrest lichee, golden pan arrest；Effect：Clearing heat and detoxicating, antiasthmatic-antitussive, relieve dizziness, high fever, infantile convulsions, epilepsy, etc. arresting convulsion.Control carbuncle swells, furunculosis, scrofula Scrofula, larynx numbness, chronic bronchitis, child convulsion twitch, snake bite and insect sting.
Oldenlandia diffusa：For the herb of Rubiaceae plants of Hedyotis oldenlandia diffusa；Scientific name： HedyotisdiffusaWilld.；Alias：HERBA HEDYOTIS DIFFUSAE, tang Huang, snake needle grass, Radix Picriae felterrae, two leaf humulus, white flower cross grass, sharp knife Grass, JIAMENGCAO, waterplantain ottelia herb, snake Lei grass, crane tongue grass；Effect：Heat-clearing, dampness removing, removing toxic substances.Control dyspnea and cough due to lung-heat, tonsillitis.Throat Inflammation, appendicitis, dysentery, urinary tract infections, jaundice, hepatitis, pelvic infecton, adnexitis, carbuncle swells furunculosis, venomous snake bite, tumour.Also can use In alimentary tract cancer.
Goldenrod：For feverfew goldenrod platymiscium goldenrod SolidagodecurrensLour. [S.virgaureaLvar.leiocarpa (Benth.) A.Gray] is with root and all herbal medicine；Alias：Sticky dish, Fallopia nervosa [Yunnan], golden radix bupleuri [southwest], the thick conjunction in mountain, tiger urine；Effect：Clearing heat and detoxicating, detumescence is except pain.It is flat for the infection of the upper respiratory tract Peach body is scorching, abscess of throat, bronchitis, pneumonia, pulmonary tuberculosis hemoptysis, acute and chronic ephritis, infantile malnutrition；Traumatic injury is controlled in external application, Venomous snake bite, sore swollen toxin, mastitis.
Chinese lobelia：For Campanulaceae Chinese lobelia LobeliachinensisLour. drying herb；Scientific name： LobeliachinensisLour.[L.radicansThunb.]；Alias：Thin rice grass, anxious solution rope, half of flower, snake Lei grass are [wide East], long cordyceps sinensis [Henan]；Effect：Inducing diuresis to remove edema, it is clearing heat and detoxicating.Stung for extensive abdominal edema, face foot edema, carbuncle swells furunculosis, snakeworm Wound；Advanced schistosomiasis ascites.
Sculellaria barbata：For labiate Sculellaria barbata ScutellariabarbataDon [S.rivularisWall] drying Herb；Scientific name：ScytekaruabarbvataD.Don(S.riu-lariasWall.)；Alias：And head is careless, narrow leaf indian skullcap herb with root, Toothbrush grass, Herba Scutellariae Darbatae；Effect：It is clearing heat and detoxicating, stagnation resolvation diuresis.For furuncle swelling toxin, abscess of throat, venomous snake bite, fall and flutter wound Bitterly, oedema, jaundice.
Nanling Yao spends：Wikstroemia indica (Linn.) C.A.Mey, is also Wikstroemia indica, and Thymelaeceae, canescent wikstroemia category fill Wood, complete stool are used as medicine.Cure mainly promoting blood circulation, dissipate the stasis of blood, detumescence, analgesic；Inappropriate medication toxic side effect is notable.
Hickory chick is Morchellaceae fungi hickory chick Morchella esculenta (L.) Pers., small top hickory chick Morchella angusticeps Peck., Morchellaconica Morchella conica Pers., Morchella crassipes Morchella crassipes (Vent.) Pers., small hickory chick Morchella deliciosa Fr. etc. fructification, examination The mycelium that pipe parent species are come for its sporinite culture.
The present invention be used for cervix tumor through percutaneous drug delivery product, by fermentation, make the polysaccharide in Chinese medicine and hickory chick A variety of polysaccharide Fa Sheng Suffix in bacterium are closed, and are made containing higher amount, a greater variety of Duo Tang Suffix compounds in the medicine of the present invention, can Immunity of organisms is significantly increased, there is the polysaccharide through being enriched caused by everfermentation similar nospecific immunity to act on, and induce body Can cancer cell in initiative recognition body, be advantageous to the reparation of injury tissue/cell, and the collaboration using medicine or resistant function, To adapt to the treatment requirement of the complicated state of an illness, adverse reaction is reduced, it is evident in efficacy, securely and reliably, take simply, have to cervix tumor Preferable therapeutic effect.
Clinical trial statistics shows, oral products of the invention, for cervix tumor patient, on the one hand, has aobvious The effect of work, the development of the state of an illness can be slowed down in time, had no toxic side effect, it is on the other hand, easy to use, patient's immunity can be improved, Recurrence is reduced, significantly improves life in patients
Embodiment
Below by way of the product and its preparation technology of the specific embodiment description present invention.
First, material：
Hickory chick (Morchella esculenta), also known as morel：Purchased from Chinese agriculture Microbiological Culture Collection management Center, the specification of deposit number 51589：Test tube slant kind (test tube specification 18mm × 180mm, about 40 milliliters).It is buying or existing There are other hickory chick bacterial strains described in technology to be also suitable the present invention.Applicant laboratory also has and also has preservation, and is prepared into examination Pipe mycelia parent species, it can be provided to the public for experimental study within 20 years from the applying date.
Chinese medicine：Chinese tallow tree root, rheum officinale, saltcake, crotons, trade route, WUHUASHE, poisonless snake, long-nosed pit viper, centipede, scorpion, flea stop, Oldenlandia diffusa, goldenrod, Chinese lobelia, Sculellaria barbata, Nanling Yao spends to be commercially available in Chinese medicine pharmacy.
Vegetable oil：Sesame oil, it is also possible to which peanut oil, rapeseed oil, salad oil, cottonseed oil, sunflower oil replace.
2nd, hydrogen rich water：Day field day inland waters.
3rd, equipment：
Super-pressure pot：DEPCOA -500, using ultra-high pressure sterilization technology (Ultra-highpressure ), processing abbreviation UHP；High pressure processing of food technology (highpressure processing).
Fermentation tank：For the patent No. 03270560.3, entitled " cover and culture tank of vaccine culturing-pot for edible " Utility model patent described in fermentation tank.
Syringe：Patent No. 200320126960.X, entitled " edible fungus liquid injection rod and the note comprising the injection rod Syringe described in the utility model patent of emitter ".
Four：Prepare parent species liquid：
1) magnesium sulfate 20g, dipotassium hydrogen phosphate 50g, potassium dihydrogen phosphate 50g, sucrose 250g are added in 18L hydrogen rich waters, is formed sediment Powder 250g, adds hydrogen rich water to be settled to 20L.
2) fluid nutrient medium 1 is injected in 500ml vials, every bottle of 400ml, one there are 50 bottles, insert portable pressure cooker Inherent 0.012MP/cm2,30min, 28 DEG C~34 DEG C are cooled to after taking-up, is put into superclean bench, fluid nutrient medium is made.
3) instrument, vessel and fluid nutrient medium are put into superclean bench, are inserted with 30g potassium permanganate and fill 50% In formalin 30ml vessel, hook, rake, pin, the knife of inoculation are put into the vessel 30min that sterilizes.
4) by test tube stock, 3 parts are cut into, every part is respectively connected in the fluid nutrient medium of 400ml/ bottles, stands 120min- 150min。
5) 72-96 hours are vibrated with 20 times/min on shaking table, microscopy produces parent species liquid without miscellaneous bacteria.
Embodiment 1. is used for No. 1 product of cervix tumor
The bulk drug matched：Chinese tallow tree root 100, rheum officinale 80, saltcake 80, crotons 30, trade route 30, WUHUASHE 5, poisonless snake 5, Long-nosed pit viper 5, centipede 5, scorpion 5, flea stop 5, oldenlandia diffusa 5, goldenrod 5, Chinese lobelia 5, Sculellaria barbata 5, and Nanling Yao spends 5；
Step 1. water, inactivated 10 minutes under 30 DEG C, 600mpa environment using super-pressure pot, after the completion of wherein 19 liters pass through Aseptic silica gel pipeline injects standby in sterile fermentation tank.
Step 2. extracts the aqueous extract of Chinese medicine：
The bulk drug matched is mounted in 100 mesh filter screens, and hydrogen rich water and the bulk drug matched, weight are added in super-pressure pot Amount is than being 4:1；
Handled 30 minutes under 30 DEG C, 800mpa environment, extract Chinese medicine stoste.
Step 3:Common fermentation
During the ready fermentation for having been injected into 19 liters of hydrogen rich waters of the Chinese medicine stoste 80L implantation steps 1 for extracting Chinese medicine is filled.Again 1 liter of parent species stoste for being implanted sequentially hickory chick bacterium is fermented.Fermentation time detects effective solids, content to for 144 hours Stop fermentation up to tank is put during more than 80g/L.
Step 4. concentrates
After putting tank, into alcohol precipitation extractor, cold water extraction diafiltration is added, then is boiled, filtered juice removes slag；Its juice adds 4 times of volumes 75 degree of alcohol infiltration , ≤30 DEG C low temperature under be soaked 5 hours, using property of the polysaccharide insoluble in ethanol, make polysaccharide from extraction It is precipitated out in liquid, after being warming up to 50 degrees Celsius of recovered alcohols, to the drying of precipitation Zai Jin Hang≤55 DEG C or spray drying, is made more Icing Sugar.
Step 5:Poultice preparation technology
After taking vegetable oil, vigorous fire to boil, slow fire boils one and a half hours, and oil temperature reaches 220-230 DEG C, burning things which may cause a fire disaster is cut off, normal Temperature lower cooling 8-12 hours, oil temperature is down between 40-45 DEG C, add dried yellow lead stirring, then slow fire is in heating Stirring, until lotion cuts off burning things which may cause a fire disaster again up to 90 DEG C, do not stop to stir, during Leng Que Zhi≤40 DEG C, add polysaccharide powder, stir 20 minutes, After pour out to spread out and be cooled to cream solid, 200-240 hours are then soaked in the cold water of flowing, are taken out standby；Wherein plant The mass ratio of oil, yellow lead and polysaccharide powder is 25:12.5:15.
Application method：45 DEG C are heated up to, is spread out in when into flow-like on cloth, is attached to patient's underbelly afflicted areas, black plaster Face covers whole region.Pasted 10 days per note, midway is taken off when having a bath, and is pasted again after washing heating and softening.
Embodiment 2. is used for No. 2 products of cervix tumor
The bulk drug 2 matched：Chinese tallow tree root 90, rheum officinale 89, saltcake 70, crotons 38, trade route 40, WUHUASHE 3, poisonless snake 8, Long-nosed pit viper 3, centipede 2, scorpion 7, flea stop 2, oldenlandia diffusa 7, goldenrod 8, Chinese lobelia 3, Sculellaria barbata 2, and Nanling Yao spends 7；
Step 1. water, inactivated 5 minutes under 25 DEG C, 600mpa environment using super-pressure pot, after the completion of wherein 10 liters pass through Aseptic silica gel pipeline injects standby in sterile fermentation tank.
Step 2. extracts the aqueous extract of Chinese medicine：
The bulk drug matched is mounted in 100 mesh filter screens, and hydrogen rich water and the bulk drug matched, weight are added in super-pressure pot Amount is than being 3:1；
Handled 50 minutes under 25 DEG C, 800mpa environment, extract Chinese medicine stoste.
Step 3:Common fermentation
During the ready fermentation for having been injected into 10 liters of hydrogen rich waters of the Chinese medicine stoste 65L implantation steps 1 for extracting Chinese medicine is filled.Again 0.3 liter of parent species stoste for being implanted sequentially hickory chick bacterium is fermented.Fermentation time detects effective solids, contained to for 120 hours Amount puts tank and stops fermentation when reaching more than 80g/L.
Step 4. concentrates
After putting tank, into alcohol precipitation extractor, cold water extraction diafiltration is added, then is boiled, filtered juice removes slag；Its juice adds 4 times of volumes 75 degree of alcohol infiltration , ≤30 DEG C low temperature under be soaked 5 hours, using property of the polysaccharide insoluble in ethanol, make polysaccharide from extraction It is precipitated out in liquid, after being warming up to 50 degrees Celsius of recovered alcohols, to the drying of precipitation Zai Jin Hang≤55 DEG C or spray drying, is made more Icing Sugar.
Step 5:Poultice preparation technology
After taking vegetable oil, vigorous fire to boil, slow fire boils one and a half hours, and oil temperature reaches 220-230 DEG C, burning things which may cause a fire disaster is cut off, normal Temperature lower cooling 8-12 hours, oil temperature is down between 40-45 DEG C, add dried yellow lead stirring, then slow fire is in heating Stirring, until lotion cuts off burning things which may cause a fire disaster again up to 90 DEG C, do not stop to stir, during Leng Que Zhi≤40 DEG C, add polysaccharide powder, stir 20 minutes, After pour out to spread out and be cooled to cream solid, 200-240 hours are then soaked in the cold water of flowing, are taken out standby；Wherein plant The mass ratio of oil, yellow lead and polysaccharide powder is 20:4:20.
Application method：45 DEG C are heated up to, is spread out in when into flow-like on cloth, is attached to patient's underbelly afflicted areas, black plaster Face covers whole region.Pasted 10 days per note, midway is taken off when having a bath, and is pasted again after washing heating and softening.
Embodiment 3. is used for No. 3 products of cervix tumor
The bulk drug 3 matched：Chinese tallow tree root 108, rheum officinale 90, saltcake 73, crotons 40, trade route 22, WUHUASHE 8, poisonless snake 3, long-nosed pit viper 2, centipede 7, scorpion 8, flea stops 3, oldenlandia diffusa 2, goldenrod 7, Chinese lobelia 8, Sculellaria barbata 3, and Nanling Yao spends 2；
Step 1. hydrogen rich water (day field day inland waters), inactivated 7 minutes under 28 DEG C, 600mpa environment using super-pressure pot, it is complete After wherein 25 liters injected by aseptic silica gel pipeline it is standby in sterile fermentation tank.
Step 2. extracts the aqueous extract of Chinese medicine：
The bulk drug matched is mounted in 100 mesh filter screens, and hydrogen rich water and the bulk drug matched, weight are added in super-pressure pot Amount is than being 6:1；
Handled 40 minutes under 35 DEG C, 800mpa environment, extract Chinese medicine stoste.
Step 3:Common fermentation
During the ready fermentation for having been injected into 25 liters of hydrogen rich waters of the Chinese medicine stoste 90L implantation steps 1 for extracting Chinese medicine is filled.Again 1.5 liters of parent species stoste for being implanted sequentially hickory chick bacterium is fermented.Fermentation time detects effective solids, contained to for 168 hours Amount puts tank and stops fermentation when reaching more than 80g/L.
Step 4. concentrates
After putting tank, into alcohol precipitation extractor, cold water extraction diafiltration is added, then is boiled, filtered juice removes slag；Its juice adds 4 times of volumes 75 degree of alcohol infiltration , ≤30 DEG C low temperature under be soaked 5 hours, using property of the polysaccharide insoluble in ethanol, make polysaccharide from extraction It is precipitated out in liquid, after being warming up to 50 degrees Celsius of recovered alcohols, to the drying of precipitation Zai Jin Hang≤55 DEG C or spray drying, is made more Icing Sugar.
Step 5:Poultice preparation technology
After taking vegetable oil, vigorous fire to boil, slow fire boils one and a half hours, and oil temperature reaches 220-230 DEG C, burning things which may cause a fire disaster is cut off, normal Temperature lower cooling 8-12 hours, oil temperature is down between 40-45 DEG C, add dried yellow lead stirring, then slow fire is in heating Stirring, until lotion cuts off burning things which may cause a fire disaster again up to 90 DEG C, do not stop to stir, during Leng Que Zhi≤40 DEG C, add polysaccharide powder, stir 20 minutes, After pour out to spread out and be cooled to cream solid, then soak 240 hours, take out standby in the cold water of flowing；Wherein vegetable oil, Huang Red and polysaccharide powder mass ratio is 15:10:15.
Application method：45 DEG C are heated up to, is spread out in when into flow-like on cloth, is attached to patient's underbelly afflicted areas, black plaster Face covers whole region.Pasted 10 days per note, midway is taken off when having a bath, and is pasted again after washing heating and softening.
Embodiment 4. is used for No. 4 products of cervix tumor
The bulk drug 4 matched：Chinese tallow tree root 110, rheum officinale 73, saltcake 90, crotons 22, trade route 20, WUHUASHE 7, poisonless snake 2, long-nosed pit viper 7, centipede 8, scorpion 3, flea stops 8, oldenlandia diffusa 3, goldenrod 2, Chinese lobelia 7, Sculellaria barbata 8, and Nanling Yao spends 3；
Step 1. hydrogen rich water (day field day inland waters), inactivated 30 minutes under 32 DEG C, 600mpa environment using super-pressure pot, it is complete After wherein 30 liters injected by aseptic silica gel pipeline it is standby in sterile fermentation tank.
Step 2. extracts the aqueous extract of Chinese medicine：
The bulk drug matched is mounted in 100 mesh filter screens, and hydrogen rich water and the bulk drug matched, weight are added in super-pressure pot Amount is than being 5:1；
Handled 45 minutes under 28 DEG C, 800mpa environment, extract Chinese medicine stoste.
Step 3:Common fermentation
During the ready fermentation for having been injected into 30 liters of hydrogen rich waters of the Chinese medicine stoste 100L implantation steps 1 for extracting Chinese medicine is filled. 2 liters of parent species stoste for being implanted sequentially hickory chick bacterium again is fermented.Fermentation time detects effective solids, contained to for 132 hours Amount puts tank and stops fermentation when reaching more than 80g/L.
Step 4. concentrates
After putting tank, into alcohol precipitation extractor, cold water extraction diafiltration is added, then is boiled, filtered juice removes slag；Its juice adds 4 times of volumes 75 degree of alcohol infiltration , ≤30 DEG C low temperature under be soaked 5 hours, using property of the polysaccharide insoluble in ethanol, make polysaccharide from extraction It is precipitated out in liquid, after being warming up to 50 degrees Celsius of recovered alcohols, to the drying of precipitation Zai Jin Hang≤55 DEG C or spray drying, is made more Icing Sugar.
Step 5. poultice preparation technology
After taking vegetable oil, vigorous fire to boil, slow fire boils one and a half hours, and oil temperature reaches 220-230 DEG C, burning things which may cause a fire disaster is cut off, normal Temperature lower cooling 8-12 hours, oil temperature is down between 40-45 DEG C, add dried yellow lead stirring, then slow fire is in heating Stirring, until lotion cuts off burning things which may cause a fire disaster again up to 90 DEG C, do not stop to stir, during Leng Que Zhi≤40 DEG C, add polysaccharide powder, stir 20 minutes, After pour out to spread out and be cooled to cream solid, then soak 240 hours, take out standby in the cold water of flowing；Wherein vegetable oil, Huang Red and polysaccharide powder mass ratio is 14:16:14.
Application method：45 DEG C are heated up to, is spread out in when into flow-like on cloth, is attached to patient's underbelly afflicted areas, black plaster Face covers whole region.Pasted 10 days per note, midway is taken off when having a bath, and is pasted again after washing heating and softening.
Embodiment 5. is used for No. 5 products of cervix tumor
The bulk drug 5 matched：Chinese tallow tree root 92, rheum officinale 70, saltcake 89, crotons 20, trade route 38, WUHUASHE 2, poisonless snake 7, Long-nosed pit viper 8, centipede 3, scorpion 2, flea stop 7, oldenlandia diffusa 8, goldenrod 3, Chinese lobelia 2, Sculellaria barbata 7, and Nanling Yao spends 8.
Step 1. hydrogen rich water (day field day inland waters), inactivated 15 minutes under 35 DEG C, 600mpa environment using super-pressure pot, it is complete After wherein 15 liters injected by aseptic silica gel pipeline it is standby in sterile fermentation tank.
Step 2. extracts the aqueous extract of Chinese medicine
The bulk drug matched is mounted in 100 mesh filter screens, and hydrogen rich water and the bulk drug matched, weight are added in super-pressure pot Amount is than being 4.5:1；
Handled 35 minutes under 32 DEG C, 800mpa environment, extract Chinese medicine stoste.
Step 3:Common fermentation
During the ready fermentation for having been injected into 15 liters of hydrogen rich waters of the Chinese medicine stoste 70L implantation steps 1 for extracting Chinese medicine is filled.Again 0.5 liter of parent species stoste for being implanted sequentially hickory chick bacterium is fermented.Fermentation time detects effective solids, contained to for 156 hours Amount puts tank and stops fermentation when reaching more than 80g/L.
Step 4. concentrates
After putting tank, into alcohol precipitation extractor, cold water extraction diafiltration is added, then is boiled, filtered juice removes slag；Its juice adds 4 times of volumes 75 degree of alcohol infiltration , ≤30 DEG C low temperature under be soaked 5 hours, using property of the polysaccharide insoluble in ethanol, make polysaccharide from extraction It is precipitated out in liquid, after being warming up to 50 degrees Celsius of recovered alcohols, to the drying of precipitation Zai Jin Hang≤55 DEG C or spray drying, is made more Icing Sugar.
Step 5. poultice preparation technology
After taking vegetable oil, vigorous fire to boil, slow fire boils one and a half hours, and oil temperature reaches 220-230 DEG C, burning things which may cause a fire disaster is cut off, normal Temperature lower cooling 8-12 hours, oil temperature is down between 40-45 DEG C, add dried yellow lead stirring, then slow fire is in heating Stirring, until lotion cuts off burning things which may cause a fire disaster again up to 90 DEG C, do not stop to stir, during Leng Que Zhi≤40 DEG C, add polysaccharide powder, stir 20 minutes, After pour out to spread out and be cooled to cream solid, then soak 240 hours, take out standby in the cold water of flowing；Wherein vegetable oil, Huang Red and polysaccharide powder mass ratio is 26:16:26
Application method：45 DEG C are heated up to, is spread out in when into flow-like on cloth, is attached to patient's underbelly afflicted areas, black plaster Face covers whole region.Pasted 10 days per note, midway is taken off when having a bath, and is pasted again after washing heating and softening.
Clinical observation on the therapeutic effect test example
Totally 128,30~52 years old age, average age 41 years old；Be single myomata 95 through Ultrasonography on Diagnosis, 2 with 33 of upper myomata.
128 patients through B ultrasound check in 1-12 months, are mainly shown as that myomata internal echo substantially increases after treatment is finished By force, part edge gradually obscures, knurl body fibrosis, and myomata decreased growth stops even reducing.
In 128
Myomata reduces 28, is at most reduced into the 25.5% of original volume；
Myomata stops growing 91, and ultrasonic examination shows as the reinforcing of myomata internal echo, and blood flow significantly reduces, follow-up 12 Have no that knurl body increases the moon；
No effect 9, find that knurl body has growth after most short 3 months.
Effective percentage 92.97%.

Claims (10)

  1. A kind of 1. raw material drug composition for being used to prepare cervix tumor percutaneous dosing product, it is characterised in that：Including A bulk drugs, With following weight：
    Chinese tallow tree root 90-110, rheum officinale 70-90, saltcake 70-90, crotons 20-40, trade route 20-40, WUHUASHE 2-8, poisonless snake 2-8, Long-nosed pit viper 2-8, centipede 2-8, scorpion 2-8, flea stop 2-8, oldenlandia diffusa 2-8, goldenrod 2-8, Chinese lobelia 2-8, Sculellaria barbata 2- 8, Nanling Yao spends 2-8.
  2. 2. composition according to claim 2, is characterised by：The A bulk drugs, there are following any group of parts by weight to match somebody with somebody Than：
    Chinese tallow tree root 100, rheum officinale 80, saltcake 80, crotons 30, trade route 30, WUHUASHE 5, poisonless snake 5, long-nosed pit viper 5, centipede 5, scorpion 5, Flea stops 5, oldenlandia diffusa 5, goldenrod 5, Chinese lobelia 5, Sculellaria barbata 5, and Nanling Yao spends 5；
    Chinese tallow tree root 90, rheum officinale 89, saltcake 70, crotons 38, trade route 40, WUHUASHE 3, poisonless snake 8, long-nosed pit viper 3, centipede 2, scorpion 7, flea Not 2, oldenlandia diffusa 7, goldenrod 8, Chinese lobelia 3, Sculellaria barbata 2, Nanling Yao spends 7；
    Chinese tallow tree root 108, rheum officinale 90, saltcake 73, crotons 40, trade route 22, WUHUASHE 8, poisonless snake 3, long-nosed pit viper 2, centipede 7, scorpion 8, Flea stops 3, oldenlandia diffusa 2, goldenrod 7, Chinese lobelia 8, Sculellaria barbata 3, and Nanling Yao spends 2；
    Chinese tallow tree root 110, rheum officinale 73, saltcake 90, crotons 22, trade route 20, WUHUASHE 7, poisonless snake 2, long-nosed pit viper 7, centipede 8, scorpion 3, Flea stops 8, oldenlandia diffusa 3, goldenrod 2, Chinese lobelia 7, Sculellaria barbata 8, and Nanling Yao spends 3；
    Chinese tallow tree root 92, rheum officinale 70, saltcake 89, crotons 20, trade route 38, WUHUASHE 2, poisonless snake 7, long-nosed pit viper 8, centipede 3, scorpion 2, flea Not 7, oldenlandia diffusa 8, goldenrod 3, Chinese lobelia 2, Sculellaria barbata 7, Nanling Yao spends 8.
  3. 3. it is a kind of for cervix tumor through percutaneous drug delivery product, it is characterised in that：
    It is that common fermentation, warp are carried out with the aqueous extract of the raw material drug composition described in claim 1 or 2 and morchella mother culture stoste Product obtained by concentration, preparation formulation.
  4. It is 4. according to claim 3 through percutaneous drug delivery product, it is characterised in that the technique of the concentration is as follows：
    The product after tank is put after common fermentation, into alcohol precipitation extractor, adds cold water extraction diafiltration, then is boiled, filtered juice removes slag；Its juice Add 75 degree of alcohol of 4 times of volumes to infiltrate to be soaked 5 hours under the low temperature of , ≤30 DEG C, using property of the polysaccharide insoluble in ethanol, make more Sugar is precipitated out from extract solution, dry to the drying of precipitation Zai Jin Hang≤55 DEG C or spraying after being warming up to 50 degrees Celsius of recovered alcohols It is dry, polysaccharide powder is made.
  5. 5. the product according to claim 3 or 4, it is characterised in that the formulation refers to is made sublimed preparation, patch by the polysaccharide powder Paste, liniment, ointment, emulsion, gel or aerosol.
  6. 6. product according to claim 5, it is characterised in that the preparation formulation, which refers to, is prepared as emplastrum, with edible oil It is auxiliary material with yellow lead, edible oil, yellow lead, the mass ratio of polysaccharide powder are in product：14-26:4-16:14-26；Preferably：25: 12.5:15,20:4:20,15:10:15,14:16:14 or 26:16:26, the water used is hydrogen rich water.
  7. 7. any described preparation methods through percutaneous drug delivery product for cervix tumor of claim 3-6, including following step Suddenly：
    (1) Chinese medicine stoste and morchella mother culture stoste of the raw material drug composition are prepared；
    (2) common fermentation：The Chinese medicine stoste carries out common fermentation with morchella mother culture stoste after diluting 20 times and obtains tunning；
    (3) it is concentrated and dried；
    (4) preparation.
  8. 8. preparation method according to claim 7, it is characterised in that：
    The common fermentation refers in fermentation tank, by volume example 65-100:10-30:0.3-2 add the Chinese medicine stoste, water, Morchella mother culture stoste, tank is put when fermentation reaches more than 80g/L to effective solid contents at room temperature；
    The technique of the concentration：The product after tank is put after common fermentation, into alcohol precipitation extractor, adds flooding diafiltration, then is boiled, Filtered juice removes slag；Its juice adds to be soaked 5 hours under 75 degree of alcohol infiltration , ≤30 DEG C low temperature of 4 times of volumes, and second is not dissolved in using polysaccharide The property of alcohol, makes polysaccharide be precipitated out from extract solution, after being warming up to 50 degrees Celsius of recovered alcohols, to precipitation Zai Jin Hang≤55 DEG C Drying or spray drying, are made polysaccharide powder；
    The extraction process of the Chinese medicine stoste is as follows：In extraction vessel, water and bulk drug are added；Water and the bulk drug weight Ratio is 3-6:1, under 25-35 DEG C, 800mpa environment extract 30-50 minutes obtain the aqueous extract of the bulk drug, it is preferable that The part by weight of water and the raw material drug composition is 4-5:1, under 28-32 DEG C, 800mpa environment extract 30-40 minutes obtain Arrive.
  9. 9. the preparation method according to claim 7 or 8, the preparation, which refers to, is made emplastrum, and preparation process is as follows：
    After taking vegetable oil, vigorous fire to boil, slow fire boils one and a half hours, and oil temperature reaches 220-230 DEG C, cuts off burning things which may cause a fire disaster, at normal temperatures 8-12 hours are cooled down, oil temperature is down between 40-45 DEG C, add dried yellow lead stirring, then slow fire stirs in heating, Until lotion cuts off burning things which may cause a fire disaster again up to 90 DEG C, do not stop to stir, during Leng Que Zhi≤40 DEG C, add polysaccharide powder, stir 20 minutes, after pour out Spread out and be cooled to cream solid, 200-240 hours, wherein vegetable oil, yellow lead and polysaccharide powder are then soaked in the cold water of flowing Mass ratio be 14-26:4-16:14-26.
  10. 10. according to any described methods of claim 7-9, it is characterised in that the water used is hydrogen rich water.
CN201711175431.1A 2017-11-22 2017-11-22 It is a kind of for cervix tumor through percutaneous drug delivery product and preparation method thereof Pending CN107669872A (en)

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Application publication date: 20180209