CN107669849A - A kind of coconut husk extract and its application in terms of rutin antiallergy ability is strengthened - Google Patents
A kind of coconut husk extract and its application in terms of rutin antiallergy ability is strengthened Download PDFInfo
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- CN107669849A CN107669849A CN201710999298.5A CN201710999298A CN107669849A CN 107669849 A CN107669849 A CN 107669849A CN 201710999298 A CN201710999298 A CN 201710999298A CN 107669849 A CN107669849 A CN 107669849A
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- Prior art keywords
- coconut husk
- extract
- rutin
- husk extract
- volume fraction
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 244000060011 Cocos nucifera Species 0.000 title claims abstract description 54
- 235000013162 Cocos nucifera Nutrition 0.000 title claims abstract description 53
- 239000010903 husk Substances 0.000 title claims abstract description 45
- 235000005493 rutin Nutrition 0.000 title claims abstract description 23
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 title claims abstract description 21
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 title claims abstract description 21
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 title claims abstract description 21
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 title claims abstract description 21
- 229960004555 rutoside Drugs 0.000 title claims abstract description 21
- 230000003266 anti-allergic effect Effects 0.000 title claims abstract description 9
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 title claims abstract 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 28
- 239000011347 resin Substances 0.000 claims abstract description 11
- 229920005989 resin Polymers 0.000 claims abstract description 11
- 239000000043 antiallergic agent Substances 0.000 claims abstract description 10
- 238000000605 extraction Methods 0.000 claims abstract description 8
- 230000006837 decompression Effects 0.000 claims abstract description 7
- 239000003480 eluent Substances 0.000 claims abstract description 7
- 238000010828 elution Methods 0.000 claims abstract description 7
- 239000000706 filtrate Substances 0.000 claims abstract description 7
- 238000010992 reflux Methods 0.000 claims abstract description 7
- 238000002360 preparation method Methods 0.000 claims abstract description 6
- 108010003272 Hyaluronate lyase Proteins 0.000 abstract description 6
- 102000001974 Hyaluronidases Human genes 0.000 abstract description 6
- 229960002773 hyaluronidase Drugs 0.000 abstract description 6
- 239000002537 cosmetic Substances 0.000 abstract description 5
- 239000003814 drug Substances 0.000 abstract description 5
- 230000002401 inhibitory effect Effects 0.000 abstract description 5
- 230000002708 enhancing effect Effects 0.000 abstract description 4
- IKGXIBQEEMLURG-NVPNHPEKSA-N rutin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-NVPNHPEKSA-N 0.000 description 15
- 239000000047 product Substances 0.000 description 9
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 239000006227 byproduct Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 241000209510 Liliopsida Species 0.000 description 1
- 235000014676 Phragmites communis Nutrition 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 235000020415 coconut juice Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000037072 sun protection Effects 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Birds (AREA)
- Botany (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
A kind of application the present invention relates to coconut husk extract and its in terms of rutin antiallergy ability is strengthened, the preparation method of coconut husk extract of the present invention comprise the following steps：(1) dry coconut husk is taken, after being crushed to 20 100 mesh, the volume fraction for adding 8 to 15 times of amounts of its quality is 80% ethanol, and refluxing extraction filters while hot after 6 to 10 hours, removes filter residue, medicinal extract is obtained after filtrate decompression concentration；(2) medicinal extract that step (1) obtains adsorbs through macroporous resin column, with the ethanol elution that volume fraction is 60 70%, collects the eluent of 46 times of amount column volumes, is concentrated under reduced pressure, is dried in vacuo to obtain the coconut husk extract.Coconut husk extract of the present invention has inhibiting rate of the enhancing rutin to hyaluronidase, that is, strengthens the antiallergy ability of rutin, can be exploited for preparing anti-allergic agent, for fields such as medicine, cosmetics.
Description
Technical field
The invention belongs to whitening sun protection field, and in particular to a kind of coconut husk extract and its enhancing rutin antiallergy ability
The application of aspect.
Background technology
Coconut (Cocos nucifera L.) is the monocotyledon of Palmae cocoanut, is that one kind has Development volue very much
Tropical industrial crops.Coconut meat is edible, can also extract oil, and coconut water (endosperm) can be beverage etc..Coconut husk (i.e. coconut endocarp), coconut palm
Chaff is the byproduct of coconut deep processing, and coconut husk is in dark brown, and quality is very solid, and at present, mainly application is made through charing to coconut husk
Into coconut husk charcoal, activated carbon is further made, otherwise application there is no report.The present invention is carried out using organic solvent to coconut husk
Extraction, the ability that there is its extract enhancing rutin to understand free radical is found, therefore, coconut husk extract can be exploited for preparing
Antioxidant is used for the fields such as medicine, food, cosmetics.
The content of the invention
The present invention provides a kind of coconut husk extract, it is characterised in that the preparation method of the coconut husk extract includes following step
Suddenly：
(1) dry coconut husk is taken, after being crushed to 20-100 mesh, the volume fraction for adding 8 to 15 times of amounts of its quality is
80% ethanol, refluxing extraction filter while hot after 6 to 10 hours, remove filter residue, medicinal extract is obtained after filtrate decompression concentration；
(2) medicinal extract that step (1) obtains adsorbs through macroporous resin column, the ethanol elution for being 60-70% with volume fraction, receives
Collect the 4-6 times of eluent for measuring column volume, be concentrated under reduced pressure, be dried in vacuo to obtain the coconut husk extract.
Macroreticular resin described in step (2) is selected from D101 types or AB8 types.
Another embodiment of the present invention provides the preparation method of above-mentioned coconut husk extract, it is characterised in that including following step
Suddenly：
(1) dry coconut husk is taken, after being crushed to 20-100 mesh, the volume fraction for adding 8 to 15 times of amounts of its quality is
80% ethanol, refluxing extraction filter while hot after 6 to 10 hours, remove filter residue, medicinal extract is obtained after filtrate decompression concentration；
(2) medicinal extract that step (1) obtains adsorbs through macroporous resin column, the ethanol elution for being 60-70% with volume fraction, receives
Collect the 4-6 times of eluent for measuring column volume, be concentrated under reduced pressure, be dried in vacuo to obtain the coconut husk extract.
Macroreticular resin described in step (2) is selected from D101 types or AB8 types.
Another embodiment of the present invention provides application of the above-mentioned coconut husk extract in anti-allergic agent is prepared.The antiallergy
Agent can be applied to the fields such as medicine, cosmetics.
Another embodiment of the present invention provides application of the above-mentioned coconut husk extract in rutin antiallergy is strengthened.
A kind of anti-allergic agent, it is characterised in that including coconut husk extract of the present invention.
A kind of anti-allergic agent, it is characterised in that including coconut husk extract of the present invention and rutin.
A kind of anti-allergic agent, it is characterised in that including coconut husk extract of the present invention and rutin, the coconut husk carries
The dosage for taking thing is the 6-8% of rutin quality.
Compared with prior art, the advantage of the invention is that：The present invention develops the byproduct of coconut deep processing --- coconut palm
Another new application of shell, i.e. coconut husk extract can strengthen inhibiting rate of the rutin to hyaluronidase, that is, strengthen the antiallergy of rutin
It ability, can be exploited for preparing anti-allergic agent, for fields such as medicine, cosmetics, be greatly enriched coconut husk discarded object
Purposes.
Embodiment
For the ease of a further understanding of the present invention, examples provided below has done more detailed description to it.But
It is that these embodiments only are not used for limiting the scope of the present invention or implementation principle, reality of the invention for being better understood from inventing
The mode of applying is not limited to herein below.
Embodiment 1
(1) take dry coconut husk (1.0kg) to be crushed to 100 mesh, add the ethanol solution that 8.0kg volume fractions are 80%,
After refluxing extraction 6 hours, filter while hot, remove filter residue, medicinal extract is obtained after filtrate decompression concentration；
(2) medicinal extract that step (1) obtains adsorbs through macroporous resin column, the ethanol elution for being 60-70% with volume fraction, receives
Collect the 4-6 times of eluent for measuring column volume, be concentrated under reduced pressure, be dried in vacuo to obtain coconut husk extract (16.8g, hereinafter referred to as product A).
Embodiment 2
(1) take dry coconut husk (1.0kg) to be crushed to 20 mesh, add the ethanol solution that 15.0kg volume fractions are 80%,
After refluxing extraction 10 hours, filter while hot, remove filter residue, medicinal extract is obtained after filtrate decompression concentration；
(2) medicinal extract that step (1) obtains adsorbs through macroporous resin column, the ethanol elution for being 60-70% with volume fraction, receives
Collect the 4-6 times of eluent for measuring column volume, be concentrated under reduced pressure, be dried in vacuo to obtain coconut husk extract (19.5g, hereinafter referred to as product B).
The antianaphylaxis of embodiment 3 is tested
According to the method for prior art, when test concentrations are 30 μ g/mL and 60 μ g/mL respectively, sample：Rutin, product A,
Product B, product A+ rutins (product A mass is the 6% of rutin quality), (product B mass is rutin quality to product B+ rutins
8%) to the inhibiting rate of hyaluronidase, the following test result of the present invention is according to Chinese Patent Application No.：201310531168.0
Described in method tested, be shown in Table 1.
Table 1
"-" represents that sample is less than 10% to the inhibiting rate of hyaluronidase.
Above-mentioned experimental result shows that product A, B almost do not have inhibitory action to hyaluronidase in itself, but work as itself and reed
Fourth mixes, and when especially its dosage is rutin quality 6%-8%, can significantly increase suppression of the rutin to hyaluronidase；This
Test result indicates that coconut husk extract can be used for the antiallergic effect of enhancing rutin, and then as additive for preparing anti-mistake
Quick dose, for fields such as medicine, cosmetics.
Claims (8)
1. a kind of coconut husk extract, it is characterised in that the preparation method of the coconut husk extract comprises the following steps：
(1) dry coconut husk is taken, after being crushed to 20-100 mesh, the volume fraction for adding 8 to 15 times of amounts of its quality is 80%
Ethanol, refluxing extraction filters while hot after 6 to 10 hours, removes filter residue, after filtrate decompression concentration medicinal extract；
(2) medicinal extract that step (1) obtains adsorbs through macroporous resin column, the ethanol elution for being 60-70% with volume fraction, collects 4-
The eluent of 6 times of amount column volumes, is concentrated under reduced pressure, is dried in vacuo to obtain the coconut husk extract.
2. the coconut husk extract described in claim 1, it is characterised in that macroreticular resin described in step (2) be selected from D101 types or
AB8 types.
3. the preparation method of the coconut husk extract described in claim any one of 1-2, it is characterised in that comprise the following steps：
(1) dry coconut husk is taken, after being crushed to 20-100 mesh, the volume fraction for adding 8 to 15 times of amounts of its quality is 80%
Ethanol, refluxing extraction filters while hot after 6 to 10 hours, removes filter residue, after filtrate decompression concentration medicinal extract；
(2) medicinal extract that step (1) obtains adsorbs through macroporous resin column, the ethanol elution for being 60-70% with volume fraction, collects 4-
The eluent of 6 times of amount column volumes, is concentrated under reduced pressure, is dried in vacuo to obtain the coconut husk extract.
4. the preparation method described in claim 3, it is characterised in that the macroreticular resin described in step (2) is selected from D101 types or AB8
Type.
5. application of the coconut husk extract described in claim any one of 1-2 in anti-allergic agent is prepared.
6. application of the coconut husk extract in rutin antiallergy is strengthened described in claim any one of 1-2.
7. a kind of anti-allergic agent, it is characterised in that including the coconut husk extract described in claim any one of 1-2.
8. the anti-allergic agent described in claim 7, it is characterised in that also including rutin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710999298.5A CN107669849B (en) | 2017-10-23 | 2017-10-23 | An antiallergic agent prepared from coconut shell extract and rutin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710999298.5A CN107669849B (en) | 2017-10-23 | 2017-10-23 | An antiallergic agent prepared from coconut shell extract and rutin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107669849A true CN107669849A (en) | 2018-02-09 |
| CN107669849B CN107669849B (en) | 2021-02-05 |
Family
ID=61141028
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710999298.5A Expired - Fee Related CN107669849B (en) | 2017-10-23 | 2017-10-23 | An antiallergic agent prepared from coconut shell extract and rutin |
Country Status (1)
| Country | Link |
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| CN (1) | CN107669849B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107596047A (en) * | 2017-10-23 | 2018-01-19 | 深圳百奥捷生物科技有限公司 | A kind of coconut husk extract and its application in terms of rutin oxidation resistance is strengthened |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101773589A (en) * | 2010-01-12 | 2010-07-14 | 海南大学 | Production method of coconut polyphenol extracts |
| CN107596047A (en) * | 2017-10-23 | 2018-01-19 | 深圳百奥捷生物科技有限公司 | A kind of coconut husk extract and its application in terms of rutin oxidation resistance is strengthened |
-
2017
- 2017-10-23 CN CN201710999298.5A patent/CN107669849B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101773589A (en) * | 2010-01-12 | 2010-07-14 | 海南大学 | Production method of coconut polyphenol extracts |
| CN107596047A (en) * | 2017-10-23 | 2018-01-19 | 深圳百奥捷生物科技有限公司 | A kind of coconut husk extract and its application in terms of rutin oxidation resistance is strengthened |
Non-Patent Citations (1)
| Title |
|---|
| NATCHAPHOL BUAMARD AND SOOTTAWAT BENJAKUL: ""Ethanolic coconut husk extract: In vitro antioxidative activity and effect on oxidative stability of shrimp oil emulsion", 《EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107596047A (en) * | 2017-10-23 | 2018-01-19 | 深圳百奥捷生物科技有限公司 | A kind of coconut husk extract and its application in terms of rutin oxidation resistance is strengthened |
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