CN107668445A - A kind of useful for sleeping, the beverage for adjusting immunity and preparation method thereof - Google Patents
A kind of useful for sleeping, the beverage for adjusting immunity and preparation method thereof Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/38—Other non-alcoholic beverages
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/70—Clarifying or fining of non-alcoholic beverages; Removing unwanted matter
- A23L2/72—Clarifying or fining of non-alcoholic beverages; Removing unwanted matter by filtration
- A23L2/74—Clarifying or fining of non-alcoholic beverages; Removing unwanted matter by filtration using membranes, e.g. osmosis, ultrafiltration
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/254—Acanthopanax or Eleutherococcus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/725—Ziziphus, e.g. jujube
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Botany (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Non-Alcoholic Beverages (AREA)
- Water Supply & Treatment (AREA)
Abstract
A kind of useful for sleeping, the beverage for adjusting immunity and preparation method thereof, belong to health drink manufacture field.The present invention for improving the coarse extract that sleep product is mostly plurality of Chinese mixing in the prior art, without steps such as grading purifications, product composition is complicated, the problem of quality standard is whard to control in production process, with ginseng, spina date seed, wilsonii, the fruit of Chinese wolfberry is raw material, according to the parts by weight of ginseng 1, the parts by weight of spina date seed 0.2~0.5, the ratio of the parts by weight of wilsonii 0.2~0.4 and the parts by weight of the fruit of Chinese wolfberry 0.05~0.2, by raw material through over cleaning, extraction, grading purification, add supplementary material, filtering, adjust sugariness, sterilizing, a kind of health drink is made in packaging and other steps.The present invention can be used for improving sleep, the healthcare field of regulation immunity.
Description
Technical field
The invention belongs to health drink manufacture field, and in particular to a kind of useful for sleeping, adjust immunity beverage and its
Preparation method.
Background technology
With the high speed development of society, people's work, rhythm of life are more and more faster, and life stress is increasing, increasingly
More people occurs using the neuropsychiatric such as tired, absent minded, sleep-disorder, myalgia, headache, depression symptom as spy
The chronic fatigue syndrome of sign.Wherein, sleep state is bad, hypoimmunity is influence people's normal work and study important
Reason, it is mainly shown as during difficulty falling asleep, sleep and easily wakes up, be easily tired, be easily sick etc..
At present, there are many regulation sleeps, improve the medicine or health products of sleep quality, but mostly plurality of Chinese mixes
Coarse extract, without steps such as grading purifications, product composition is complicated, and quality standard is difficult to control in production process.
The content of the invention
The problem of existing for prior art, the invention provides a kind of useful for sleeping, the beverage of regulation immunity.
The beverage is made of following raw material extracts through water：The parts by weight of ginseng 1, the parts by weight of spina date seed 0.2~0.5, thorn
The parts by weight of slender acanthopanax 0.2~0.4 and the parts by weight of the fruit of Chinese wolfberry 0.05~0.2.
Preferably, the beverage is made of following raw material extracts through water：The parts by weight of ginseng 1, the weight of spina date seed 0.2~0.4
Measure part, the parts by weight of wilsonii 0.2~0.3 and the parts by weight of the fruit of Chinese wolfberry 0.05~0.1.
It is highly preferred that the beverage is made of following raw material extracts through water：The parts by weight of ginseng 1, the weight of spina date seed 0.2
Part, the parts by weight of wilsonii 0.2 and the parts by weight of the fruit of Chinese wolfberry 0.1.
Present invention also offers the preparation method of a kind of useful for sleeping, the beverage for adjusting immunity, comprise the following steps：
(1) extract：Raw material ginseng, spina date seed, wilsonii, the fruit of Chinese wolfberry are added water to cook, crude extract is obtained, is obtained after filtering
Obtain extract solution；
(2) grading purification：Precipitation and impurity are removed after step (1) extract solution is centrifuged, is then classified through membrane filtration, is intercepted
Molecular weight is 1000~50000Da extract；
(3) 5~10L beverage meters are obtained according to 100g raw material gross weights, the extract that step (2) obtains are diluted with water,
Sugariness is then adjusted, beverage is obtained after sterilization.
Preferably：
Before raw material described in step (1) decocts, 3-5 hours are soaked in water.
Step (1) temperature that decocts is 50 DEG C -80 DEG C, and the time is 1 hour.
Step (2) described centrifugal rotational speed is 2000~4000rpm/min.
Step (3) the regulation sugariness refers to that it is 5~12 to add fructose syrup regulation pol.
Step (3) sterilizing is degerming for ultraviolet sterilization or membrane filtration.
Beneficial effect
Confirmed fatigue is more due to the dysfunction of the spleen in transport, and the biochemical weary source of qi and blood, lucid yang failing to raise, failure in sending down turbid yin, limb muscle loses foster etc.
Cause, be related to the vital organs of the human body, mainly based on spleen, liver, kidney.It can be recuperated under medical treatment by dialectical prescription, to reach prevention, treatment, control
Effect.Qi-restoratives righting, tired calm the nerves of dispelling are one of medical treatment methods of confirmed fatigue.The solid member of one side qi-restoratives, empty to mend, canonical
Prosperous, fatigue is removed certainly；On the other hand, will is adjusted, refreshing to pacify, the heart is then peaceful, and fatigue can disappear.The health drink of the present invention have been directed to
Confirmed fatigue crowd be mostly the dysfunction of the spleen in transport, disorder of qi and blood card and design, using ginseng as monarch drug in a prescription, reinforce the spleen to benefit the lung, blood-nourishing of promoting the production of body fluid；Acid
Jujube kernel is ministerial drug, nourishing heart tonifying liver, antitoxic heart-soothing and sedative；Wilsonii is adjutant, and strengthening spleen, tonifying kidney, calming the nerves, it is tired to dispel；The fruit of Chinese wolfberry nourishes to make medicine
Liver kidney.Four taste Chinese herbal medicines share, can beneficial spleen, filling liver kidney, regulating the qi flowing in the channels blood, reach the purpose of " Guyuan is calmed the nerves ".
The beverage of the present invention also has the following advantages that：
1. the beverage provided by the invention to conduce to sleep is by four taste traditional Chinese medicine extractions, purifying gained, compared to existing skill
Art, raw material type is few, and production process is simple and convenient easy to operate, and target level of product quality is easily controlled.
2. the present invention utilizes membrane filtration classification technique, the composition in extract solution is retained, leaves and takes molecular weight ranges
For 1000~50000Da composition.It effectively removes in small molecule and big molecular impurity and beverage placement process and be also easy to produce precipitation
Composition, improve product quality.
3. the present invention prepares beverage using above-mentioned four tastes Chinese medicine, functional component contained by each raw material complements each other, and compensate for list
One raw material improves the deficiency and defect of sleeper effect, and daily 1~2 bottle, 300~500mL/ bottles, drink to improve for a long time
Sleep, also there is the effect for improving immunity.
Embodiment
It is a kind of useful for sleeping described in the present embodiment of embodiment 1., adjusts the beverage of immunity, by following raw material through water extraction
Made of taking：The parts by weight of ginseng 1, the parts by weight of spina date seed 0.2~0.5, the parts by weight of wilsonii 0.2~0.4 and the fruit of Chinese wolfberry 0.05~
0.2 parts by weight.
The beverage is prepared by the following procedure method and is made：
(1) extract：Raw material ginseng, spina date seed, wilsonii, the fruit of Chinese wolfberry are added water to cook, crude extract is obtained, is obtained after filtering
Obtain extract solution；
(2) grading purification：Precipitation and impurity are removed after step (1) extract solution is centrifuged, is then classified through membrane filtration, is intercepted
Molecular weight is 1000~50000Da extract；
(3) 5~10L beverage meters are obtained according to 100g raw material gross weights, the extract that step (2) obtains are diluted with water,
Sugariness is then adjusted, beverage is obtained after sterilization.
The present embodiment of embodiment 2. is the further restriction to embodiment 1, a kind of useful for sleeping, tune described in the present embodiment
The beverage of immunity is saved, made of following raw material extracts through water：The parts by weight of ginseng 1, the parts by weight of spina date seed 0.2~0.4, thorn five
Add 0.2~0.3 parts by weight and the parts by weight of the fruit of Chinese wolfberry 0.05~0.1.
The beverage is prepared by the following procedure method and is made：
(1) extract：Raw material ginseng, spina date seed, wilsonii, the fruit of Chinese wolfberry are added water to cook, crude extract is obtained, is obtained after filtering
Obtain extract solution；
(2) grading purification：Precipitation and impurity are removed after step (1) extract solution is centrifuged, is then classified through membrane filtration, is intercepted
Molecular weight is 1000~50000Da extract；
(3) 5~10L beverage meters are obtained according to 100g raw material gross weights, the extract that step (2) obtains are diluted with water,
Sugariness is then adjusted, beverage is obtained after sterilization.
The present embodiment of embodiment 3. is the further restriction to embodiment 1,2, a kind of useful for sleeping described in the present embodiment,
The beverage of immunity is adjusted, made of following raw material extracts through water：The parts by weight of ginseng 1, the parts by weight of spina date seed 0.2, wilsonii
0.2 parts by weight and the parts by weight of the fruit of Chinese wolfberry 0.1.
The beverage is prepared by the following procedure method and is made：
(1) extract：Raw material ginseng, spina date seed, wilsonii, the fruit of Chinese wolfberry are added water to cook, crude extract is obtained, is obtained after filtering
Obtain extract solution；
(2) grading purification：Precipitation and impurity are removed after step (1) extract solution is centrifuged, is then classified through membrane filtration, is intercepted
Molecular weight is 1000~50000Da extract；
(3) 5~10L beverage meters are obtained according to 100g raw material gross weights, the extract that step (2) obtains are diluted with water,
Sugariness is then adjusted, beverage is obtained after sterilization.
It is a kind of useful for sleeping described in the present embodiment of embodiment 4., adjusts the preparation method of the beverage of immunity, including such as
Lower step：
(1) extract：Raw material ginseng, spina date seed, wilsonii, the fruit of Chinese wolfberry are added water to cook, crude extract is obtained, is obtained after filtering
Obtain extract solution；
(2) grading purification：Precipitation and impurity are removed after step (1) extract solution is centrifuged, is then classified through membrane filtration, is intercepted
Molecular weight is 1000~50000Da extract；
(3) 5~10L beverage meters are obtained according to 100g raw material gross weights, the extract that step (2) obtains are diluted with water,
Sugariness is then adjusted, beverage is obtained after sterilization.
The present embodiment of embodiment 5. is the further restriction to embodiment 4, a kind of useful for sleeping, tune described in the present embodiment
The preparation method of the beverage of immunity is saved, before the raw material described in step (1) decocts, 3-5 hours are soaked in water.
The present embodiment is by raw material soaking 3-5 hours so that the active ingredient of raw material is more preferably released in follow-up decoction process
Release.
The present embodiment of embodiment 6. is the further restriction to embodiment 4, a kind of useful for sleeping, tune described in the present embodiment
The preparation method of the beverage of immunity is saved, step (1) temperature that decocts is 50 DEG C -80 DEG C, and the time is 1 hour.
The present embodiment uses 50 DEG C -80 DEG C of temperature, decocts 1 hour, it is possible to prevente effectively from high temperature is to material effective component
Destruction, preferably keep active ingredient vigor.
The present embodiment of embodiment 7. is the further restriction to embodiment 4, a kind of useful for sleeping, tune described in the present embodiment
The preparation method of the beverage of immunity is saved, step (2) described centrifugal rotational speed is 2000~4000rpm/min.
Above-mentioned rotating speed can realize precipitation and the effect of impurity, and those skilled in the art can determine have according to rotating speed
Body centrifugation time.
The present embodiment of embodiment 8. is the further restriction to embodiment 4, a kind of useful for sleeping, tune described in the present embodiment
The preparation method of the beverage of immunity is saved, step (3) the regulation sugariness refers to that it is 5~12 to add fructose syrup regulation pol.
Experiment shows that mouthfeel is optimal when pol is 8.
The present embodiment of embodiment 9. is the further restriction to embodiment 4, a kind of useful for sleeping, tune described in the present embodiment
The preparation method of the beverage of immunity is saved, step (3) sterilizing is degerming for ultraviolet sterilization or membrane filtration.
The present embodiment of embodiment 10. specifically describe a kind of useful for sleeping, adjust immunity beverage preparation method.
(1) extract：Select raw material, the parts by weight of ginseng 1, the parts by weight of spina date seed 0.2, the parts by weight of wilsonii 0.2, the fruit of Chinese wolfberry
0.1 parts by weight, raw material gross weight 100g, after cleaning up, 1L drinking water immersion 3-5 hours are added, 50 DEG C of -80 DEG C of heating are decocted
Boil, extract 1h.Crude extract is obtained, is filtered using Simple filter net, obtains extract solution；
(2) grading purification：Step (1) extract solution is removed to precipitation and impurity after 3000rpm/min is centrifuged, then through film
Filtering hierarchical, the extract that interception molecular weight is 1000~50000Da, the main composition as beverage.
(3) extract that step (2) obtains is diluted with water to 10L, it is 8 then to adjust sugariness, through ultraviolet sterilization or film
Beverage is obtained after filtration sterilization.
Above-mentioned beverage can by beverage it is canned be 300~500mL/ bottles, also can be canned as needed.Label is posted, is stored at
Temperature be 15-18 DEG C, relative humidity be 65%-75% environment in, it is standby.
The basis of experimental example 1.《Health food is examined and assessment technique specification》Detection method specified in (2003 editions), to this
The beverage that invention provides improve the Function detection of sleep.
1. experimental method：Healthy adult mouse, single sex, 18-22 grams, every group of 10-15 is only.If 1 blank control group
With 3 given the test agent dosage groups, by beverage in embodiment 10 according to 10:1 ratio concentrates, and carries out function assessment experiment.According to human body
Daily per kilogram of body weight recommended intake, expands 5,10,20 times of basic, normal, high dosage groups as mouse experiment.In this test example
Basic, normal, high dosage group gavage amount is respectively 0.1ml, 0.2ml, 0.4ml, and given the test agent gives the time, is orally continuously given in principle
Give 30 days, the sets itself time limit also can be needed according to experiment.
(1) direct sleep experiments
Observation animal gives the given the test agent of 3 dosage, and blank control group gives same volume solvent (present invention selection distilled water
For solvent) after, if there is sleep phenomenon, sleep using righting reflex loss as index., can be immediately when mouse is placed in dorsal position
Right body position；Such as more than the 30-60 seconds can not the person of righting, that is, righting reflex loss is thought, into sleep.Righting reflex recovers
Animal is awakened, and righting reflex loss is the animal sleep time to this period is recovered, and records blank control group and test sample group
Sleep number of animals and the length of one's sleep.
Compare blank control group and experimental group sleep number of animals and the difference between the length of one's sleep, if sleep number of animals and sleeping
Time increase of sleeping has conspicuousness, then experimental result is positive.
(2) experiment of the yellow Jackets length of one's sleep is extended
After animal last gives blank control and various concentrations given the test agent, there are 10-15 minutes before peak effect, to each group
Yellow Jackets are injected intraperitoneally in animal, injection volume 0.2mL/20g, using righting reflex loss as index, observe given the test agent energy
The no extension yellow Jackets length of one's sleep.
Compare the difference between blank control group and the extension of the experimental group length of one's sleep, length of one's sleep extension has conspicuousness, then
Experimental result is positive.
(3) hypnosis of yellow Jackets (or barbital sodium) sub-threshold dose is tested
Preliminary experiment is first carried out before formal experiment, determines pentobarbital sodium sub-threshold lull dosage (16-30mg/kg.bw or bar ratio
Appropriate sodium 100-150mg/kgBW), the yellow Jackets maximum sub-threshold dose that VCB 80-90% mouse righting reflex does not disappear.It is dynamic
After thing last gives blank control and various concentrations given the test agent, there is 10-15 minutes before peak effect, the intraperitoneal injection of each group animal
Yellow Jackets maximum subthreshold hypnotic dosage, sleep number of animals (righting reflex loss up to more than 1 minute person) in record 30 minutes.
Experiment is preferably carried out under 24-25 DEG C of quiet environment.
Compare the difference between blank control group and experimental group sleep number of animals, incidence of sleep animals increase has significantly
Property, then experimental result is positive.
(4) barbital sodium Sleep latency is tested
On the basis of barbital sodium hypnosis, whether observation tested material can shorten dropping asleep latency, if Sleep latency contracts
It is short, then illustrate that tested material and calmine have synergy.
Animal last gave blank control and after various concentrations given the test agent 10-20 minute, was injected intraperitoneally to each group animal
Barbital sodium, injection volume 0.2mL/20g, using righting reflex loss as index, observation given the test agent is slept latent to barbital sodium
The influence of volt phase.
Difference between comparative experiments group and blank control group Sleep latency, Sleep latency, which shortens, conspicuousness, then
Experimental result is positive.
(5) data analysis
Data carry out statistical analysis using SPSS 17.0.The length of one's sleep is measurement data, and data are carried out using variance analysis
Statistics, appropriate variable is carried out to the data of abnormal or heterogeneity of variance and changed, after normal state is met or variance requires together, with turning
Data after changing are counted；If being still not up to normal state or the neat purpose of variance after variable conversion, use rank test instead and united
Meter.Sleep number of animals is enumeration data, using chi-square criterion.
(6) result judgement
Extend the yellow Jackets length of one's sleep experiment, the hypnosis of yellow Jackets (or barbital sodium) sub-threshold dose experiment, bar
The binomial positive in three experiments is tested than appropriate sodium Sleep latency, and is acted on without obvious directly sleep, can determine that the given the test agent
Acted on sleep is improved.
2. experimental result
(1) direct sleep experiments
Each test group gives given the test agent, after negative control group gives same volume solvent, it is observed that 30min, righting reflex
In the presence of not occurring sleep phenomenon.
(2) to the influence of the mouse yellow Jackets length of one's sleep
Analysis of variance, its group difference are not reaching to significance, are shown in Table 1, and illustrate that the given the test agent does not have
Significantly extend the effect of the yellow Jackets length of one's sleep.
Influence of the beverage of table 1 to the mouse yellow Jackets length of one's sleep
(3) hypnosis of yellow Jackets sub-threshold dose is tested
For basic, normal, high dosage group animal sleep rate compared with blank control group, difference has statistical significance, is shown in Table 2 institutes
Show, illustrate that the sample can increase yellow Jackets sub-threshold dose animal sleep rate.
Influence of the beverage of table 2 to mouse yellow Jackets sub-threshold dose syngignoscism
(4) barbital sodium Sleep latency is tested
For basic, normal, high dosage group animal barbital sodium Sleep latency compared with negative control group, difference has conspicuousness,
It is shown in Table 3, illustrates that the given the test agent can shorten Sleep latency, given the test agent has synergy with barbital sodium.
Influence of the beverage of table 3 to mouse barbital sodium Sleep latency
(5) result is with discussing
Beverage provided by the invention can cooperate with yellow Jackets sub-threshold dose syngignoscism and shorten barbital sodium sleep and dive
Fu Qi, acted on without direct sleep.The sleep beverage for prompting this of the invention has obvious cooperate with yellow Jackets and barbital sodium
Effect, according to the Ministry of Public Health《Health food is examined and assessment technique specification》Criterion in (version in 2003), the beverage have
Improve the function of sleep.
Experimental example 2. adjusts immunocompetence experiment
1. experimental method：
Healthy adult mouse, single sex, 18-22 grams.If 1 blank control group (distilled water) and 3 given the test agent agent
Amount group, by beverage according to 10:1 ratio is concentrated, and carries out function assessment experiment, recommends intake according to the daily per kilogram of body weight of human body
Amount, expand 5,10,20 times of basic, normal, high concentration dose groups as mouse experiment.Basic, normal, high dosage group gavage in this test example
Amount is respectively 0.1ml, 0.2ml, 0.4ml, and one time a day, continuous feeding is put to death after 7 days.
(1) influence of the product to macrophages phagocytic capacity and NO generative capacities
The preparation of peritoneal macrophage：Mouse cervical dislocation is put to death, sterilization.Abdominal cavity is opened, D-Hank ' s solution rinses, and receives
Collect peritoneal fluid, 4 DEG C of low-temperature centrifugations.Repetition D-Hank ' s solution is rinsed twice, and supernatant, RPMI-1640 trainings are abandoned after low-temperature centrifugation
Support base and cell is resuspended.Calculate and adjust cell concentration to 5 × 106Individual/mL, 1mL/ hole are added in 6 orifice plates.Culture plate is placed in
5%CO2Cultivated under the conditions of 37 DEG C of constant incubator, culture plate is cleaned 2-3 times with 37 DEG C of D-Hank ' s liquid of pre-temperature, removing is not pasted
Wall or the bad macrophage of adherence quality, remaining is the adherent macrophage of purifying.
Influence to macrophage phagocytosis dimethyl diaminophenazine chloride ability：Using PBS compound concentrations be 0.075% neutral red solution,
Filtering, it is degerming.Neutral red solution (100 μ L/ holes) is added into macrophage, cultivates 1-2h.Culture plate is cleaned, adds 100 μ L
Cell pyrolysis liquid (ethanol：Acetic acid=1:1, v/v), after 2h, the light absorption value of reaction solution when ELIASA Detection wavelength is 550nm.
Influence to macrophage generation NO：By macrophage with 1 × 106The concentration in individual/hole is added in 24 orifice plates.Will
Tissue Culture Plate is placed in 5%CO2, cultivate 48h in 37 DEG C of constant incubators, cells and supernatant (100 μ L) is transferred to 96 holes
In culture plate, isometric Griess reagents, lucifuge reaction 10min are added.ELIASA detects light absorption value during 540nm wavelength.
With NaNO3Do standard curve for reference material, sample stimulus hole is calculated according to light absorption value and standard curve corresponding to NO contents.
(2) statistical analysis
Analytic statistics is carried out to the data obtained, calculates average and SD values, application software SPSS 12.0 carries out data processing,
Ensure that 3 experiments repeat.Generally use one-way analysis of variance method compares the relation between multi-group data.Work as P<When 0.01, table
Show that experimental group is extremely notable with control group difference；P<When 0.05, experimental group has significant difference with control group.
2. experimental result
(1) influence of the product to mouse macrophage phagocytosis
Test result indicates that basic, normal, high concentration can promote mouse macrophage phagocytosis, difference tool in various degree
There is conspicuousness, prompt the product that there is the effect of certain regulation immunity.
Influence of the product of table 4 to mouse macrophage phagocytosis
| Sample concentration and-gavage amount | A540 | P values |
| Compare (distilled water) | 0.22 | |
| Low concentration (0.1mL) | 0.34 | 0.042 |
| Middle concentration (0.2mL) | 0.41 | 0.037 |
| High concentration (0.4mL) | 0.45 | 0.026 |
(2) influence of the product to mouse macrophage NO nucleus formations
Test result indicates that basic, normal, high concentration can increase the NO generative capacities of mouse macrophage in various degree, it is dense
Degree more high activity is more obvious, and difference has conspicuousness, prompts the product to have the effect of certain regulation immunity.
Influence of the product of table 5 to mouse macrophage NO nucleus formations
To sum up, instant invention overcomes the shortcomings of existing formula is complicated, functional component is uncertain, optimal prescription ratio is utilized
Example, simplest extraction process, obtain the beverage products with improvement sleep, regulation efficacy of immunity.Production power consumption is low, takes
It is few, meet the requirement of national green environmental protection.
For comparative example using a kind of following data verifications useful for sleeping of the present invention, the beverage of regulation immunity, its is each
Composition complements each other caused effect.
Comparative example 1. is using 1 parts by weight ginseng as raw material, after cleaning up, adds 1L drinking water and soaks 3-5 hours, 50 DEG C-
80 DEG C of heating decoct, and extract 1h.Crude extract is obtained, is filtered using Simple filter net, obtains extract solution；With reference to embodiment
Step (2), (3) methods described obtain beverage, and filling storage in 10.
Comparative example 2. is using 0.2 parts by weight spina date seed as raw material, after cleaning up, adds 1L drinking water and soaks 3-5 hours, and 50
DEG C of -80 DEG C heating decoct, and extract 1h.Crude extract is obtained, is filtered using Simple filter net, obtains extract solution；With reference to real
Apply step (2) in example 10, (3) methods described acquisition beverage, and filling storage.
Comparative example 3. is using 0.2 parts by weight wilsonii as raw material, after cleaning up, adds 1L drinking water and soaks 3-5 hours, and 50
DEG C of -80 DEG C heating decoct, and extract 1h.Crude extract is obtained, is filtered using Simple filter net, obtains extract solution；With reference to real
Apply step (2) in example 10, (3) methods described acquisition beverage, and filling storage.
Comparative example 4. is using the 0.1 parts by weight fruit of Chinese wolfberry as raw material, after cleaning up, adds 1L drinking water and soaks 3-5 hours, and 50
DEG C of -80 DEG C heating decoct, and extract 1h.Crude extract is obtained, is filtered using Simple filter net, obtains extract solution；With reference to real
Apply step (2) in example 10, (3) methods described acquisition beverage, and filling storage.
Comparative example 5. cleans up using 1 parts by weight ginseng, 0.2 parts by weight spina date seed and 0.2 parts by weight wilsonii as raw material
Afterwards, 1L drinking water immersion 3-5 hours are added, 50 DEG C of -80 DEG C of heating decoct, and extract 1h.Crude extract is obtained, utilizes Simple filter
Net is filtered, and obtains extract solution；Beverage, and filling storage are obtained with reference to step (2), (3) methods described in embodiment 10.
Comparative example 6. is using 0.2 parts by weight spina date seed, 0.2 parts by weight wilsonii and the 0.1 parts by weight fruit of Chinese wolfberry as raw material, cleaning
After clean, 1L drinking water immersion 3-5 hours are added, 50 DEG C of -80 DEG C of heating decoct, and extract 1h.Crude extract is obtained, using simple
Screen pack is filtered, and obtains extract solution；Beverage, and filling storage are obtained with reference to step (2), (3) methods described in embodiment 10
Deposit.
Comparative example 7. cleans up using 1 parts by weight ginseng, 0.2 parts by weight spina date seed, the 0.1 parts by weight fruit of Chinese wolfberry as raw material
Afterwards, 1L drinking water immersion 3-5 hours are added, 50 DEG C of -80 DEG C of heating decoct, and extract 1h.Crude extract is obtained, utilizes Simple filter
Net is filtered, and obtains extract solution；Beverage, and filling storage are obtained with reference to step (2), (3) methods described in embodiment 10.
Comparative example 8. cleans up using 1 parts by weight ginseng, 0.2 parts by weight wilsonii and the 0.1 parts by weight fruit of Chinese wolfberry as raw material
Afterwards, 1L drinking water immersion 3-5 hours are added, 50 DEG C of -80 DEG C of heating decoct, and extract 1h.Crude extract is obtained, utilizes Simple filter
Net is filtered, and obtains extract solution；Beverage, and filling storage are obtained with reference to step (2), (3) methods described in embodiment 10.
Healthy adult mouse is selected, single sex, 18-22 grams, every group of 10-15 is only.Beverage described in embodiment 10 is pressed
According to 10:1 ratio concentrates, and carries out function assessment experiment.According to the daily per kilogram of body weight recommended intake of human body, it is small to expand 10 times of conducts
The dosage of mouse experiment, this test example gavage amount is 0.2ml, meanwhile, other group of mouse is given single or wherein any 3 kinds respectively
Beverage prepared by material combination, orally continuously gives 30 days, the sets itself time limit also can be needed according to experiment in principle.Experiment knot
Mice sleep situation is counted after beam.
The different material of table 6 is to improving sleeper effect statistics
In summary, the present invention is raw material using ginseng, spina date seed, wilsonii and the fruit of Chinese wolfberry, and the drink prepared is extracted through water
Material, is prepared compared to single raw material or the combination of part material, its improvement are slept better.
Claims (9)
1. a kind of useful for sleeping, the beverage for adjusting immunity, it is characterised in that the beverage is made up of following raw material through water extraction
's：The parts by weight of ginseng 1, the parts by weight of spina date seed 0.2~0.5, the parts by weight of wilsonii 0.2~0.4 and the weight of the fruit of Chinese wolfberry 0.05~0.2
Part.
2. a kind of useful for sleeping according to claim 1, adjust immunity beverage, it is characterised in that the beverage be by
Made of following raw material is extracted through water：The parts by weight of ginseng 1, the parts by weight of spina date seed 0.2~0.4, the parts by weight of wilsonii 0.2~0.3
With the parts by weight of the fruit of Chinese wolfberry 0.05~0.1.
3. a kind of useful for sleeping according to claim 1, adjust immunity beverage, it is characterised in that the beverage be by
Made of following raw material is extracted through water：The parts by weight of ginseng 1, the parts by weight of spina date seed 0.2, the parts by weight of wilsonii 0.2 and the fruit of Chinese wolfberry 0.1
Parts by weight.
A kind of 4. preparation side of the beverage of useful for sleeping, regulation immunity described in claim 1-3 any one claims
Method, comprise the following steps：
(1) extract：Raw material ginseng, spina date seed, wilsonii and the fruit of Chinese wolfberry are added water to cook, crude extract is obtained, is obtained after filtering
Extract solution；
(2) grading purification：Precipitation and impurity are removed after step (1) extract solution is centrifuged, is then classified through membrane filtration, intercepts molecule
Measure the extract for 1000~50000Da；
(3) 5~10L beverage meters are obtained according to 100g raw material gross weights, the extract that step (2) obtains is diluted with water, then
Sugariness is adjusted, beverage is obtained after sterilization.
5. the preparation method of the beverage of a kind of useful for sleeping according to claim 4, regulation immunity, it is characterised in that
Before raw material described in step (1) decocts, soaked 3~5 hours in water.
6. the preparation method of the beverage of a kind of useful for sleeping according to claim 4, regulation immunity, it is characterised in that
Step (1) temperature that decocts is 50 DEG C~80 DEG C, and the time is 1 hour.
7. the preparation method of the beverage of a kind of useful for sleeping according to claim 4, regulation immunity, it is characterised in that
Step (2) described centrifugal rotational speed is 2000~4000rpm/min.
8. the preparation method of the beverage of a kind of useful for sleeping according to claim 4, regulation immunity, it is characterised in that
Step (3) the regulation sugariness refers to that it is 5~12 to add fructose syrup regulation pol.
9. the preparation method of the beverage of a kind of useful for sleeping according to claim 4, regulation immunity, it is characterised in that
Step (3) sterilizing is degerming for ultraviolet sterilization or membrane filtration.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102697047A (en) * | 2012-06-11 | 2012-10-03 | 宁夏红中宁枸杞制品有限公司 | Method for preparing oral liquid of Chinese wolfberry |
| CN106138289A (en) * | 2016-08-10 | 2016-11-23 | 福建润兴生物科技有限公司 | Health care oral liquid of sleep and preparation method thereof is improved for enhancing immunity |
-
2017
- 2017-10-18 CN CN201710971950.2A patent/CN107668445A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102697047A (en) * | 2012-06-11 | 2012-10-03 | 宁夏红中宁枸杞制品有限公司 | Method for preparing oral liquid of Chinese wolfberry |
| CN106138289A (en) * | 2016-08-10 | 2016-11-23 | 福建润兴生物科技有限公司 | Health care oral liquid of sleep and preparation method thereof is improved for enhancing immunity |
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| Title |
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| 李端等: "《天然药物化学》", 30 September 2013, 中国医药科技出版社 * |
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