CN107667109B - 可用于分子和生物分子的18f标记的新的杂芳族硅-氟化物-受体及其制备方法 - Google Patents

可用于分子和生物分子的18f标记的新的杂芳族硅-氟化物-受体及其制备方法 Download PDF

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CN107667109B
CN107667109B CN201680030562.8A CN201680030562A CN107667109B CN 107667109 B CN107667109 B CN 107667109B CN 201680030562 A CN201680030562 A CN 201680030562A CN 107667109 B CN107667109 B CN 107667109B
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CN107667109A (zh
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克里斯多佛·马丁·沃尔德曼
安东·A·陶拓夫
詹尼弗·玛丽·墨菲
R·H·格鲁布斯
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California Institute of Technology
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University of California San Diego UCSD
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/12—Organo silicon halides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A61K51/1072—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from the reproductive system, e.g. ovaria, uterus, testes or prostate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/004—Acyclic, carbocyclic or heterocyclic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur, selenium or tellurium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Reproductive Health (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201680030562.8A 2015-05-26 2016-05-24 可用于分子和生物分子的18f标记的新的杂芳族硅-氟化物-受体及其制备方法 Active CN107667109B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562166240P 2015-05-26 2015-05-26
US62/166,240 2015-05-26
PCT/US2016/033923 WO2016191424A2 (en) 2015-05-26 2016-05-24 Novel heteroaromatic silicon-fluoride-acceptors useful for 18f labeling of molecules and biomolecules, and methods of preparing same

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CN107667109A CN107667109A (zh) 2018-02-06
CN107667109B true CN107667109B (zh) 2021-08-03

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US (4) US10800797B2 (enExample)
EP (1) EP3303349B1 (enExample)
JP (2) JP7266365B2 (enExample)
CN (1) CN107667109B (enExample)
CA (1) CA2982269C (enExample)
WO (1) WO2016191424A2 (enExample)

Families Citing this family (8)

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JP7266365B2 (ja) 2015-05-26 2023-04-28 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 分子および生体分子の１８ｆ標識化に有用な新規な複素芳香環フッ化ケイ素アクセプタおよびその調製方法
US11413360B2 (en) * 2017-07-28 2022-08-16 Technische Universität München Dual mode radiotracer and—therapeutics
WO2019055825A1 (en) 2017-09-15 2019-03-21 The Regents Of The University Of California INHIBITION OF AMINOACYLASE 3 (AA3) IN THE TREATMENT OF CANCER
EP3917581A1 (en) * 2019-01-30 2021-12-08 Technische Universität München Silicon-fluoride acceptor substituted radiopharmaceuticals and precursors thereof
WO2020220020A1 (en) * 2019-04-26 2020-10-29 The Regents Of The University Of California Silicon-fluoride heteroaromatic systems for applications in positron emission tomography (pet) molecular imaging
EP3976562A1 (en) * 2019-05-24 2022-04-06 Duke University 18 f-radiolabeled biomolecules
US20230202944A1 (en) * 2020-05-29 2023-06-29 Fuzionaire, Inc. Methods for Rapid Formation of Chemicals Including Positron Emission Tomography Biomarkers
CN119301134A (zh) * 2022-04-20 2025-01-10 富齐奥奈尔治疗诊断股份有限公司 治疗诊断用的氟化硅杂芳族系统及其方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012087908A1 (en) * 2010-12-22 2012-06-28 Ge Healthcare Limited Her2 binding peptides labeled with aluminium-[18] fluoride complexed by nota

Family Cites Families (4)

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US6972336B2 (en) * 2002-07-18 2005-12-06 Novartis Ag N-alkylation of indole derivatives
WO2008040441A2 (en) 2006-10-02 2008-04-10 Bayer Schering Pharma Aktiengesellschaft Silicon derivatives for pet imaging
WO2010075286A1 (en) * 2008-12-24 2010-07-01 University Of Washington MOLECULAR ACTIVATORS OF THE Wnt/β-CATENIN PATHWAY
JP7266365B2 (ja) 2015-05-26 2023-04-28 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 分子および生体分子の１８ｆ標識化に有用な新規な複素芳香環フッ化ケイ素アクセプタおよびその調製方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012087908A1 (en) * 2010-12-22 2012-06-28 Ge Healthcare Limited Her2 binding peptides labeled with aluminium-[18] fluoride complexed by nota

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
C. Baum等.Lithium-silylindolide als Precursor fuÈr 1,2-, 1,3-Bis(silyl)indole und Bis(indol-1,3-yl)silane.《Zeitschrift fur Anorganische und Allgemeine Chemie》.1999,第625卷(第12期),1969-1978. *
Cross-Coupling and Carbonylative Cross-Coupling of Organofluorosilanes with Hypervalent lodonium Tetrafluoroborates;Suk-Ku Kang等;《Tetrahedron》;19971231;第53卷(第9期);3027-3034 *
Indolyl- and pyrrolylsilanes. Syntheses and crystal structures;Frenzel, Andrea等;《 Zeitschrift fuer Naturforschung, B: Chemical Sciences》;19951231;第50卷(第11期);1658-1664 *
Lukas O. Dialer等.Studies toward the Development of New Silicon-Containing Building Blocks for the Direct 18F‑Labeling of Peptides.《Journal of Medicinal Chemistry》.2013,第56卷7552-7563. *
Studies toward the Development of New Silicon-Containing Building Blocks for the Direct 18F‑Labeling of Peptides;Lukas O. Dialer等;《Journal of Medicinal Chemistry》;20130830;第56卷;7552-7563 *

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Publication number Publication date
EP3303349B1 (en) 2022-07-06
JP2021073293A (ja) 2021-05-13
US20180346491A1 (en) 2018-12-06
EP3303349A4 (en) 2019-03-13
CN107667109A (zh) 2018-02-06
JP7266365B2 (ja) 2023-04-28
WO2016191424A2 (en) 2016-12-01
US20230114064A1 (en) 2023-04-13
US12371445B2 (en) 2025-07-29
US10800797B2 (en) 2020-10-13
CA2982269C (en) 2023-12-05
WO2016191424A3 (en) 2016-12-29
US20200377529A1 (en) 2020-12-03
JP2018521956A (ja) 2018-08-09
US20250333425A1 (en) 2025-10-30
CA2982269A1 (en) 2016-12-01
EP3303349A2 (en) 2018-04-11
US11447508B2 (en) 2022-09-20

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