CN107660207B - 丁丙诺啡乙酸盐及用于制备丁丙诺啡的方法 - Google Patents

丁丙诺啡乙酸盐及用于制备丁丙诺啡的方法 Download PDF

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Publication number
CN107660207B
CN107660207B CN201680027202.2A CN201680027202A CN107660207B CN 107660207 B CN107660207 B CN 107660207B CN 201680027202 A CN201680027202 A CN 201680027202A CN 107660207 B CN107660207 B CN 107660207B
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China
Prior art keywords
buprenorphine
less
free base
acetate
blend
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Expired - Fee Related
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CN201680027202.2A
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English (en)
Chinese (zh)
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CN107660207A (zh
Inventor
C·弗雷德里克·M·亨特利
埃里克·韦恩·卡泰斯托
黑尔格·阿尔弗雷德·赖施
阿尔沙纳·夏尔马
亚克·拉里·斯蒂米斯特
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Rhodes Technologies Inc
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Rhodes Technologies Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN201680027202.2A 2015-03-10 2016-03-09 丁丙诺啡乙酸盐及用于制备丁丙诺啡的方法 Expired - Fee Related CN107660207B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562131114P 2015-03-10 2015-03-10
US62/131,114 2015-03-10
PCT/IB2016/051332 WO2016142877A1 (en) 2015-03-10 2016-03-09 Acetate salt of buprenorphine and methods for preparing buprenorphine

Publications (2)

Publication Number Publication Date
CN107660207A CN107660207A (zh) 2018-02-02
CN107660207B true CN107660207B (zh) 2020-09-29

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CN201680027202.2A Expired - Fee Related CN107660207B (zh) 2015-03-10 2016-03-09 丁丙诺啡乙酸盐及用于制备丁丙诺啡的方法

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US (6) US10406152B2 (enrdf_load_stackoverflow)
EP (1) EP3283490A1 (enrdf_load_stackoverflow)
JP (2) JP6660399B2 (enrdf_load_stackoverflow)
KR (2) KR20200045010A (enrdf_load_stackoverflow)
CN (1) CN107660207B (enrdf_load_stackoverflow)
AR (1) AR103902A1 (enrdf_load_stackoverflow)
AU (2) AU2016230750B2 (enrdf_load_stackoverflow)
BR (1) BR112017019357A2 (enrdf_load_stackoverflow)
CA (2) CA2977732C (enrdf_load_stackoverflow)
CO (1) CO2017009130A2 (enrdf_load_stackoverflow)
EA (1) EA201792014A1 (enrdf_load_stackoverflow)
IL (1) IL254384A0 (enrdf_load_stackoverflow)
MA (1) MA45902A (enrdf_load_stackoverflow)
MX (1) MX2017011606A (enrdf_load_stackoverflow)
NZ (1) NZ735736A (enrdf_load_stackoverflow)
PH (1) PH12017501641A1 (enrdf_load_stackoverflow)
SG (1) SG11201707350TA (enrdf_load_stackoverflow)
TW (2) TWI699367B (enrdf_load_stackoverflow)
WO (1) WO2016142877A1 (enrdf_load_stackoverflow)

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GB2527254B (en) 2013-03-15 2020-07-15 Univ Leland Stanford Junior Benzylisoquinoline alkaloids (BIA) Producing microbes, and methods of making and using the same
CN105829541B (zh) 2013-11-04 2022-08-12 小利兰·斯坦福大学托管委员会 产生苄基异喹啉生物碱(bia)前体的微生物以及制备和使用所述前体的方法
AU2016230750B2 (en) * 2015-03-10 2019-05-30 Rhodes Technologies Acetate salt of buprenorphine and methods for preparing buprenorphine
CN107614688B (zh) 2015-05-04 2023-02-28 小利兰·斯坦福大学托管委员会 产生苄基异喹啉生物碱(bia)前体的微生物及其制备和使用方法
IL255136B2 (en) 2015-05-08 2023-09-01 Univ Leland Stanford Junior Methods for generating epimerases and benzylisoquinoline alkaloids
AU2017345328C1 (en) 2016-10-18 2023-03-02 Antheia, Inc. Methods of producing nor-opioid and nal-opioid benzylisoquinoline alkaloids
BR112020002050A2 (pt) 2017-08-03 2020-09-08 Antheia, Inc. epimerases engenheiradas alcaloides benzilisoquinolina e métodos de produção de alcaloides benzilisoquinolina
AR117426A1 (es) * 2018-05-11 2021-08-04 Alar Pharmaceuticals Inc Formulaciones inyectables de acción prolongada y formas cristalinas de derivados de buprenorfina
AU2023287208A1 (en) * 2022-06-24 2024-12-12 Alar Pharmaceuticals Inc. Stable pharmaceutical composition of buprenorphine and preparation method and use thereof

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AU2019203308A1 (en) 2019-05-30
SG11201707350TA (en) 2017-10-30
US10835528B2 (en) 2020-11-17
TWI699367B (zh) 2020-07-21
EA201792014A1 (ru) 2018-01-31
AU2016230750A1 (en) 2017-10-12
BR112017019357A2 (pt) 2018-06-05
US10406152B2 (en) 2019-09-10
PH12017501641A1 (en) 2018-02-12
KR20170137738A (ko) 2017-12-13
EP3283490A1 (en) 2018-02-21
CN107660207A (zh) 2018-02-02
US20170197975A1 (en) 2017-07-13
JP6660399B2 (ja) 2020-03-11
AU2016230750B2 (en) 2019-05-30
JP2020033359A (ja) 2020-03-05
CA3104099A1 (en) 2016-09-15
US20180235955A1 (en) 2018-08-23
US20190298713A1 (en) 2019-10-03
US20180162866A1 (en) 2018-06-14
TW201639856A (zh) 2016-11-16
US10874662B2 (en) 2020-12-29
US10278967B2 (en) 2019-05-07
US9926329B2 (en) 2018-03-27
MA45902A (fr) 2019-06-19
US20210046066A1 (en) 2021-02-18
US20190314364A1 (en) 2019-10-17
MX2017011606A (es) 2017-10-26
IL254384A0 (en) 2017-11-30
KR20200045010A (ko) 2020-04-29
JP2018507882A (ja) 2018-03-22
NZ735736A (en) 2019-02-22
WO2016142877A1 (en) 2016-09-15
TW202037597A (zh) 2020-10-16
CA2977732C (en) 2021-02-23
CA2977732A1 (en) 2016-09-15
CO2017009130A2 (es) 2017-11-21
AR103902A1 (es) 2017-06-14

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