CN107648174A - A kind of anti-acne of extract of stem cell containing blueberry repairs shin moisturizer and preparation method - Google Patents

A kind of anti-acne of extract of stem cell containing blueberry repairs shin moisturizer and preparation method Download PDF

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Publication number
CN107648174A
CN107648174A CN201711062269.2A CN201711062269A CN107648174A CN 107648174 A CN107648174 A CN 107648174A CN 201711062269 A CN201711062269 A CN 201711062269A CN 107648174 A CN107648174 A CN 107648174A
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composition
parts
extract
shin moisturizer
stem cell
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王飞
王一飞
葛啸虎
陈海佳
王小燕
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Guangzhou Saliai StemCell Science and Technology Co Ltd
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Guangzhou Saliai StemCell Science and Technology Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/99Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dermatology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Cosmetics (AREA)

Abstract

The invention discloses a kind of anti-acne of extract of stem cell containing blueberry to repair shin moisturizer and preparation method, belongs to technical field of skin care, the composition of anti-acne reparation includes the component of following mass fraction:4~9 parts of 10~16 parts of blueberry stem cell extract, 5~10 parts of hamamelis extract and camomile extract;The weight/mass percentage composition of composition is 9% in shin moisturizer.The present invention composition and prepare shin moisturizer not but not damage skin, and anti-acne repair the effect of it is good.

Description

A kind of anti-acne of extract of stem cell containing blueberry repairs shin moisturizer and preparation method
Technical field
The invention belongs to the anti-acne of technical field of skin care, more particularly to a kind of stem cell containing blueberry extract to repair skin care Liquid and preparation method.
Background technology
The whelk of face is formed by following several factors:1) smegma is vigorous, sebum accumulation;2) on follicular orifice Skin hyperplasia keratinization, hair follicle block;3) propionibacterium acnes amount reproduction, hair follicle inflammatory reaction.However, existing anti-acne The synthesis chemical reagent added in remediation composition and skin care item is excessive, easily damages skin;Secondly, the effect of anti-acne is repaired Difference.
Therefore, it is necessary to prepare new composition and skin care item, its not but not damage skin, and anti-acne reparation The effect of it is good.
The content of the invention
Present invention aims to overcome that the shortcomings of the prior art, and a kind of dispelling for extract of stem cell containing blueberry is provided Acne repairs shin moisturizer and preparation method, the shin moisturizer of said composition and its preparation not but not damage skin, and anti-acne reparation The effect of it is good.
To achieve the above object, the technical scheme taken of the present invention is:A kind of composition of anti-acne reparation, it includes following The component of mass fraction:10~16 parts of blueberry stem cell extract, 5~10 parts of hamamelis extract and camomile extract 4~9 Part.
Blueberry stem cell extract contains various active composition, such as anthocyanidin, and anthocyanidin has antioxidation activity, can reduce The degree of injury that face's epidermal stem cells induce under extraneous factor, makes epidermal stem cells maintain vigour.Hamamelis extract energy Regulate and control the secretion of grease, effectively improve skin water content, and there is anti-inflammation.Camomile extract includes celery Element, apiolin have the effect of anti-oxidant, anti-inflammatory and Shu Min.
The preparation method of blueberry stem cell extract comprises the following steps:
1) part for blueberry pulp is chosen, carry out disinfection processing;Chopping is seeded on MS culture mediums, dark training at 25 DEG C Support;The outer paraphyte of propagation is taken out after two weeks, separates and is transferred in subculture medium and cultivate, subculture once, obtains every two weeks To blueberry stem cell;
2) culture medium after culture blueberry stem cell is collected, through ultrafiltration membrance filter, concentration filtrate, retains the work in culture medium Property composition;Culture medium and the lysate of blueberry stem cell are freeze-dried, obtain blueberry stem cell extract.
The composition of the present invention includes blueberry stem cell extract, hamamelis extract and camomile extract, blueberry and done Cell extract, hamamelis extract and camomile extract can keep face's epidermal stem cells in the range of certain proportion Vigor, reduce secretion and the anti-inflammation of grease, can efficiently anti-acne reparation;And said composition is mostly natural materials, to skin Skin not damaged.
As the improvement of above-mentioned technical proposal, composition includes the component of following mass fraction:Blueberry stem cell extract 5~6 parts of 10~13 parts, 6~8 parts of hamamelis extract and camomile extract.
As the improvement of above-mentioned technical proposal, composition also includes tea tree ethereal oil.Tea tree ethereal oil can restrain pore, antibacterial disappears Inflammation, further enhance the effect of composition anti-acne is repaired.
As the further improvement of above-mentioned technical proposal, the mass fraction of the tea tree ethereal oil is 4~9 parts.
As the further improvement of above-mentioned technical proposal, the composition is made up of the component of following mass fraction:It is blue 4~9 parts of 10~13 parts of certain kind of berries stem cell extract, 6~8 parts of hamamelis extract, 5~6 parts of camomile extract and tea tree ethereal oil.
As the further improvement of above-mentioned technical proposal, the mass ratio of the hamamelis extract and the tea tree ethereal oil For 1~2.When the mass ratio of hamamelis extract and tea tree ethereal oil is 1~2, hamamelis extract has association with tea tree ethereal oil The effect of being repaired with anti-acne.
In addition, the present invention also provides application of the described composition in skin care item.
In addition, the present invention also provides a kind of shin moisturizer for including described composition.
As the improvement of above-mentioned technical proposal, the shin moisturizer is made up of the component of following weight/mass percentage composition:Composition 9%th, NMF 20% and emulsifying agent 17%, surplus are deionized water.
In addition, the present invention also provides a kind of preparation method of described shin moisturizer, comprise the following steps successively:
S1) composition is added in deionized water, in 80 DEG C of heating stirring 2h, obtains mixture I;
S2) to step S1) NMF and emulsifying agent are added in the mixture I, in 60 DEG C of heating stirring 1h, after cooling To shin moisturizer.
The beneficial effects of the present invention are:The present invention provides a kind of anti-acne of the extract of stem cell containing blueberry and repairs shin moisturizer And preparation method, blueberry stem cell extract, hamamelis extract, camomile extract in composition and shin moisturizer of the invention Quality with tea tree ethereal oil efficiently can carry out anti-acne reparation in the range of certain proportion to face;And said composition and shield It is mostly natural materials in skin liquid, to skin zero damage;In addition, hamamelis extract and tea tree ethereal oil can cooperate with anti-acne reparation.
Embodiment
For the object, technical solutions and advantages of the present invention are better described, below in conjunction with specific embodiment and subordinate list pair The present invention is described further.
Embodiment 1
A kind of composition of anti-acne reparation, it is made up of the component of following mass fraction:10 parts of blueberry stem cell extract, 6 parts of 10 parts of hamamelis extract and camomile extract.
The present embodiment also provides a kind of shin moisturizer, and it is made up of the component of following weight/mass percentage composition:Composition 9%, protect Humectant (butantriol) 20% and emulsifying agent (sorbierite olive grease) 17%, surplus is deionized water.
The present embodiment also provides the preparation method of the shin moisturizer, comprises the following steps successively:
S1) skin care compositions is added in deionized water, in 80 DEG C of heating stirring 2h, obtains mixture I;
S2) to step S1) NMF and emulsifying agent are added in the mixture I, in 60 DEG C of heating stirring 1h, after cooling To shin moisturizer.
The preparation method of blueberry stem cell extract comprises the following steps in composition:
1) part for blueberry pulp is chosen, carry out disinfection processing;Chopping is seeded on MS culture mediums, dark training at 25 DEG C Support;The outer paraphyte of propagation is taken out after two weeks, separates and is transferred in subculture medium and cultivate, subculture once, obtains every two weeks To blueberry stem cell;
2) culture medium after culture blueberry stem cell is collected, through ultrafiltration membrance filter, concentration filtrate, retains the work in culture medium Property composition;Culture medium and the lysate of blueberry stem cell are freeze-dried, obtain blueberry stem cell extract.
Embodiment 2
A kind of composition of anti-acne reparation, it is made up of the component of following mass fraction:16 parts of blueberry stem cell extract, 4 parts of 8 parts of hamamelis extract and camomile extract.
The present embodiment also provides a kind of shin moisturizer, and it is made up of the component of following weight/mass percentage composition:Composition 9%, protect Humectant (butantriol) 20% and emulsifying agent (sorbierite olive grease) 17%, surplus is deionized water.
The preparation method of shin moisturizer described in the present embodiment refers to embodiment 1.
Embodiment 3
A kind of composition of anti-acne reparation, it is made up of the component of following mass fraction:13 parts of blueberry stem cell extract, 9 parts of 5 parts of hamamelis extract and camomile extract.
The present embodiment also provides a kind of shin moisturizer, and it is made up of the component of following weight/mass percentage composition:Composition 9%, protect Humectant (butantriol) 20% and emulsifying agent (sorbierite olive grease) 17%, surplus is deionized water.
The preparation method of shin moisturizer described in the present embodiment refers to embodiment 1.
Embodiment 4
A kind of composition of anti-acne reparation, it is made up of the component of following mass fraction:10 parts of blueberry stem cell extract, 4 parts of 6 parts of hamamelis extract, 5 parts of camomile extract and tea tree ethereal oil.
The present embodiment also provides a kind of shin moisturizer, and it is made up of the component of following weight/mass percentage composition:Composition 9%, protect Humectant (butantriol) 20% and emulsifying agent (sorbierite olive grease) 17%, surplus is deionized water.
The preparation method of shin moisturizer described in the present embodiment refers to embodiment 1.
Embodiment 5
A kind of composition of anti-acne reparation, it is made up of the component of following mass fraction:Blueberry stem cell extract 11.3 Part, 8 parts of hamamelis extract, 5.6 parts of camomile extract and 4 parts of tea tree ethereal oil.
The present embodiment also provides a kind of shin moisturizer, and it is made up of the component of following weight/mass percentage composition:Composition 9%, protect Humectant (butantriol) 20% and emulsifying agent (sorbierite olive grease) 17%, surplus is deionized water.
The preparation method of shin moisturizer described in the present embodiment refers to embodiment 1.
Embodiment 6
A kind of composition of anti-acne reparation, it is made up of the component of following mass fraction:13 parts of blueberry stem cell extract, 7 parts of 7 parts of hamamelis extract, 6 parts of camomile extract and tea tree ethereal oil.
The present embodiment also provides a kind of shin moisturizer, and it is made up of the component of following weight/mass percentage composition:Composition 9%, protect Humectant (butantriol) 20% and emulsifying agent (sorbierite olive grease) 17%, surplus is deionized water.
The preparation method of shin moisturizer described in the present embodiment refers to embodiment 1.
Embodiment 7
A kind of composition of anti-acne reparation, it is made up of the component of following mass fraction:Blueberry stem cell extract 11.3 Part, 8 parts of hamamelis extract, 5.6 parts of camomile extract and 9 parts of tea tree ethereal oil.
The present embodiment also provides a kind of shin moisturizer, and it is made up of the component of following weight/mass percentage composition:Composition 9%, protect Humectant (butantriol) 20% and emulsifying agent (sorbierite olive grease) 17%, surplus is deionized water.
The preparation method of shin moisturizer described in the present embodiment refers to embodiment 1.
Comparative example 1
A kind of composition of anti-acne reparation, it is made up of the component of following mass fraction:Blueberry stem cell extract 11.3 10 parts of part, 5 parts of hamamelis extract and camomile extract.
The present embodiment also provides a kind of shin moisturizer, and it is made up of the component of following weight/mass percentage composition:Composition 9%, protect Humectant (butantriol) 20% and emulsifying agent (sorbierite olive grease) 17%, surplus is deionized water.
The preparation method of shin moisturizer described in the present embodiment refers to embodiment 1.
Comparative example 2
A kind of composition of anti-acne reparation, it is made up of the component of following mass fraction:8 parts of blueberry stem cell extract, 5.6 parts of 10 parts of hamamelis extract and camomile extract.
The present embodiment also provides a kind of shin moisturizer, and it is made up of the component of following weight/mass percentage composition:Composition 9%, protect Humectant (butantriol) 20% and emulsifying agent (sorbierite olive grease) 17%, surplus is deionized water.
The preparation method of shin moisturizer described in the present embodiment refers to embodiment 1.
Effect example 1
1) propionibacterium acnes Anaerobic culturel 24h in dextrose broth is taken, afterwards with 0.03mol/L PBSs, Bacteria concentration is made as 106Cfu/mL bacteria suspension;Take shin moisturizer 1g to add in above-mentioned 0.1mL bacteria suspensions uniformly to mix, after 20min 9mL 0.03mol/L PBS are added, are fully mixed;After appropriate dilution, wherein 3 dilution factors are taken, takes 1mL to be placed in two respectively and puts down In row culture dish, nutrient solution, Hybrid NC machine tool are added.Bacterium colony is recorded after 48h, is averaged, while sets blank control.Inhibiting rate Calculation formula be:The clump count of (clump count of clump count-shin moisturizer of blank control)/blank control.
It is randomly divided into 5 groups:A11 groups use the shin moisturizer of embodiment 1, and B11 groups use the shin moisturizer of embodiment 2, and C11 groups make With the shin moisturizer of embodiment 3, D11 groups use the shin moisturizer of comparative example 1, and E11 groups use the shin moisturizer of comparative example 2, inhibiting rate Measurement result is as shown in table 1.
Table 1
Group A11 groups B11 groups C11 groups D11 groups E11 groups
Inhibiting rate/% 52.6 51.3 53.0 30.3 34.8
As shown in table 1, the propionibacterium acnes inhibiting rate of A11, B11 and C11 group is more than the acne propionic acid of D11 and E11 groups Bacillus inhibiting rate;As can be seen here, when the mass fraction of blueberry stem cell extract in composition is 10~16 parts, witch hazel is extracted The mass fraction of thing is 5~10 parts, when the mass fraction of camomile extract is 4~9 parts, the acne third of composition and shin moisturizer It is preferable that acidfast bacilli suppresses effect.
2) choosing face has the volunteer of whelk, and week for 7 weeks smears shin moisturizer to face;Surveyed with skin oil and fat tester Surely smear shin moisturizer before and after face skin oil and fat content, calculate facial skin grease reduced rate.
250 volunteers are taken, are randomly divided into 5 groups:A12 groups smear the shin moisturizer of embodiment 1, and B12 groups smear embodiment 2 Shin moisturizer, C12 groups smear the shin moisturizer of embodiment 3, and D12 groups smear the shin moisturizer of embodiment 4, and E12 groups smear the shield of embodiment 5 Skin liquid, the measurement result of skin oil and fat reduced rate are as shown in table 2.
Table 2
Group A12 groups B12 groups C12 groups D12 groups E12 groups
Skin oil and fat reduced rate/% 17.6 18.3 18.0 11.5 10.6
As shown in table 2, the skin oil and fat reduced rate of A12, B12 and C12 group is more than the skin oil and fat reduction of D12 and E12 groups Rate;As can be seen here, when the mass fraction of blueberry stem cell extract in composition is
10~16 parts, the mass fraction of hamamelis extract is 5~10 parts, and the mass fraction of camomile extract is 4~9 Part when, composition and skin care liquid energy preferably reduce the secretory volume of skin oil and fat.
Comprehensive Tables 1 and 2, it is seen that when the mass fraction of blueberry stem cell extract in composition is 10~16 parts, gold is in detail The mass fraction of prunus mume extract is 5~10 parts, when the mass fraction of camomile extract is 4~9 parts, composition and skin care liquid energy Preferably anti-acne reparation.
Effect example 2
1) effect example 1 is referred to, is randomly divided into 7 groups:A21 groups use the shin moisturizer of embodiment 1, and B21 groups use embodiment 2 Shin moisturizer, C21 groups use the shin moisturizer of embodiment 3, and D21 groups use the shin moisturizer of embodiment 4, and E21 groups use the shield of embodiment 5 Skin liquid, F21 groups use the shin moisturizer of embodiment 6, and G21 groups use the shin moisturizer of embodiment 7, the measurement result such as table 3 of inhibiting rate It is shown.
Table 3
Group A21 groups B21 groups C21 groups D21 groups E21 groups F21 groups G21 groups
Inhibiting rate/% 52.6 51.3 53.0 65.3 66.1 66.3 60.8
As shown in table 3, the propionibacterium acnes inhibiting rate of A21, B21 and C21 group is less than the propionibacterium acnes suppression of G21 groups Rate processed, the propionibacterium acnes inhibiting rate of G21 groups are less than the propionibacterium acnes inhibiting rate of D21, E21 and F21 group;Thus may be used See, when the mass fraction of blueberry stem cell extract in composition is
10~13 parts, the mass fraction of hamamelis extract is 6~8 parts, and the mass fraction of camomile extract is 5~6 Part, 4~9 parts of the mass fraction of tea tree ethereal oil, and the mass ratio of hamamelis extract and tea tree ethereal oil be 1~2 when, composition and It is more preferable that the propionibacterium acnes of shin moisturizer suppresses effect.
2) effect example 1 is referred to, 350 volunteers is taken, is randomly divided into 7 groups:A22 groups smear the shin moisturizer of embodiment 1, B22 Group smears the shin moisturizer of embodiment 2, and C22 groups smear the shin moisturizer of embodiment 3, and D22 groups smear the shin moisturizer of embodiment 4, E22 groups The shin moisturizer of embodiment 5 is smeared, F22 groups smear the shin moisturizer of embodiment 6, and G22 groups smear the shin moisturizer of embodiment 7, skin oil The measurement result of fat reduced rate is as shown in table 4.
Table 4
As shown in table 4, the skin oil and fat reduced rate of A22, B22 and C22 group is less than the skin oil and fat reduced rate of G22 groups, G22 The skin oil and fat reduced rate of group is less than the skin oil and fat reduced rate of D22, E22 and F22 group;As can be seen here, when blueberry in composition The mass fraction of stem cell extract is 10~13 parts, and the mass fraction of hamamelis extract is 6~8 parts, camomile extract Mass fraction be 5~6 parts, 4~9 parts of the mass fraction of tea tree ethereal oil, and the mass ratio of hamamelis extract and tea tree ethereal oil For 1~2 when, composition and skin care liquid energy more preferably reduce well the secretory volume of skin oil and fat.
Consolidated statement 3 and table 4, it is seen that when the mass fraction of blueberry stem cell extract in composition is 10~13 parts, gold is in detail The mass fraction of prunus mume extract is 6~8 parts, and the mass fraction of camomile extract is 5~6 parts, the mass fraction 4 of tea tree ethereal oil ~9 parts, and the mass ratio of hamamelis extract and tea tree ethereal oil be 1~2 when, composition and skin care liquid energy preferably anti-acne are repaiied It is multiple.
Effect example 3
Choosing 200 faces has the volunteer of whelk, is randomly divided into 4 groups:A3 groups smear the shin moisturizer of comparative example 1, B3 Group smears the shin moisturizer of embodiment 1, and C3 groups smear the shin moisturizer of embodiment 4, the shin moisturizer of D3 groups embodiment 7;The face of volunteer Portion is early daily, evening respectively smears 1 shin moisturizer, continuous to smear 5 weeks, during which without using other skin care item;After 5 weeks, survey will Hope person's using effect, efficacy result are shown in Table 5;Efficacy assessment standard is as follows:It is effective:Face's whelk is largely reduced, and skin becomes Smoother;Effectively:Face's whelk has been reduced, and skin becomes somewhat smooth;It is invalid:Face's whelk and skin change are not Substantially.
Table 5
Group Effective/people Effectively/people Invalid/people
A3 groups 1 19 30
B3 groups 10 35 5
C3 groups 25 24 1
D3 groups 17 32 1
As shown in table 4, after volunteer is smeared using the shin moisturizer group of the application, whelk is largely reduced, and skin becomes to compare It is more smooth;Especially when blueberry stem cell extract in composition mass fraction be 10~13 parts, the quality of hamamelis extract Number is 6~8 parts, and the mass fraction of camomile extract is 5~6 parts, 4~9 parts of the mass fraction of tea tree ethereal oil, and witch hazel When the mass ratio of extract and tea tree ethereal oil is 1~2, composition and the preferably anti-acne reparation of skin care liquid energy.
Finally, it should be noted that above example to illustrate technical scheme rather than to the present invention protect The limitation of scope, although being explained in detail with reference to preferred embodiment to the present invention, one of ordinary skill in the art should manage Solution, technical scheme can be modified or replaced on an equal basis, without departing from technical solution of the present invention essence and Scope.

Claims (10)

1. a kind of composition of anti-acne reparation, it is characterised in that include the component of following mass fraction:Blueberry stem cell extract 4~9 parts of 10~16 parts, 5~10 parts of hamamelis extract and camomile extract.
2. composition as claimed in claim 1, it is characterised in that include the component of following mass fraction:Blueberry stem cell carries Take 5~6 parts of 10~13 parts of thing, 6~8 parts of hamamelis extract and camomile extract.
3. composition as claimed in claim 1, it is characterised in that also comprising tea tree ethereal oil.
4. composition as claimed in claim 3, it is characterised in that the mass fraction of the tea tree ethereal oil is 4~9 parts.
5. composition as claimed in claim 4, it is characterised in that be made up of the component of following mass fraction:Blueberry stem cell 4~9 parts of 10~13 parts of extract, 6~8 parts of hamamelis extract, 5~6 parts of camomile extract and tea tree ethereal oil.
6. the composition as described in any one of claim 3~5, it is characterised in that the hamamelis extract and the tea tree The mass ratio of essential oil is 1~2.
7. application of the composition as described in any one of claim 1~6 in skin care item.
A kind of 8. shin moisturizer for including the composition as described in power requires 1~6 any one.
9. shin moisturizer as claimed in claim 8, it is characterised in that be made up of the component of following weight/mass percentage composition:Composition 9%th, NMF 20% and emulsifying agent 17%, surplus are deionized water.
10. a kind of preparation method of shin moisturizer as claimed in claim 9, it is characterised in that comprise the following steps successively:
S1) composition is added in deionized water, in 80 DEG C of heating stirring 2h, obtains mixture I;
S2) to step S1) NMF and emulsifying agent are added in the mixture I, in 60 DEG C of heating stirring 1h, protected after cooling Skin liquid.
CN201711062269.2A 2017-10-31 2017-10-31 A kind of anti-acne of extract of stem cell containing blueberry repairs shin moisturizer and preparation method Withdrawn CN107648174A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105748343A (en) * 2016-02-25 2016-07-13 广州市科玮生物技术有限公司 Natural plant extract composition and application thereof in cosmetics

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105748343A (en) * 2016-02-25 2016-07-13 广州市科玮生物技术有限公司 Natural plant extract composition and application thereof in cosmetics

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
王建新 等: "《化妆品植物原料大全》", 30 June 2012, 中国纺织出版社 *

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Application publication date: 20180202