CN107647139A - A kind of functional drug with genital tract mucosal effect and preparation method thereof - Google Patents
A kind of functional drug with genital tract mucosal effect and preparation method thereof Download PDFInfo
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- CN107647139A CN107647139A CN201710958384.1A CN201710958384A CN107647139A CN 107647139 A CN107647139 A CN 107647139A CN 201710958384 A CN201710958384 A CN 201710958384A CN 107647139 A CN107647139 A CN 107647139A
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/116—Heterocyclic compounds
- A23K20/132—Heterocyclic compounds containing only one nitrogen as hetero atom
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Abstract
The invention belongs to veterinary drug technical field, specifically discloses a kind of functional drug with genital tract mucosal effect, it is characterised in that every 100 parts of functional drugs are made up of the raw material of following weight：4 ~ 6 parts of dihydropyridine, 1 ~ 2 part of pungent essential oil compound, 0.4 ~ 0.6 part of Chinese medical extract, surplus is auxiliary material.Functional drug provided by the invention with genital tract mucosal effect, apply in additive for farm animal feed, avoid the drawbacks of being brought in the past using the method for injection sex hormone, can effectively solve animal reproduction dysfunction, the development of the reproductive function of animal body, hormonal readiness and genital organ is adjusted simultaneously, livestock and poultry breeding and childbirth performance are improved, effectively improves culture benefit.
Description
Technical field
The invention belongs to field of medicine preparing technology, and in particular to it is a kind of with genital tract mucosal effect functional drug and
Its preparation method.
Background technology
In recent years, the horizontal rapid growth of China's livestock, livestock culture play important support in China's economic industry
Act on and the accounting in national economy increasingly increases.The Reproductive Performance of animal be restrict poultry industry development scale it is crucial because
Element.The reason for causing animals' reproduction function to decline is varied, mainly there is incompatible, summer high temperature season between organism character
The many factors such as the influence of section and feeding environment.The general measure of regulation livestock and poultry Reproductive Performance is to be adjusted using sex hormone drug
Section, but injectivity hormonal medicaments have inconvenience in production, can cause livestock and poultry stress reaction, upset livestock and poultry normal endocrine；And
Sex hormone can only temporary influence livestock and poultry sexual behaviour, it is impossible to fundamentally solves the Reproductive Performance of livestock and poultry, can accelerate livestock and poultry numerous on the contrary
Degenerative is grown, shortens breeding stock utilization periods.It would therefore be highly desirable to studying green, environmentally friendly class that new suitable livestock and poultry use has life
Grow the functional drug of adjustment effect.
The content of the invention
Present invention aims to overcome that prior art defect, there is provided a kind of green, environmentally friendly class has what genital tract mucosal acted on
Functional drug and preparation method thereof, the drawbacks of being brought in the past using injectivity Hormonal methods is which obviated, can effectively solve to move
Thing breeding function obstacle, fundamentally improves the reproductive function of livestock and poultry, and has no toxic side effect.
To achieve the above object, the present invention is achieved through the following technical solutions：
A kind of functional drug with genital tract mucosal effect, it is mainly by dihydropyridine, pungent essential oil compound, traditional Chinese medicine extraction
Thing and auxiliary material composition, specifically, every 100 parts of functional drugs are made up of the raw material of following weight：Dihydropyridine 4 ~ 6
Part, 1 ~ 2 part of pungent essential oil compound, 0.4 ~ 0.6 part of Chinese medical extract, surplus is auxiliary material.
Specifically, the Chinese medical extract is one in Shorthorned Epimedium P.E, Semen Cuscutae extract and Radix Morindae Officinalis extract
Kind or two or more mixtures.
Specifically, the auxiliary material can be DEXTROSE ANHYDROUS and/or anhydrous sucrose.
The preparation method of the above-mentioned functional drug with genital tract mucosal effect, specifically includes following steps：Take in proportion
Each raw material, first dihydropyridine and Chinese medical extract are crushed, mixed after sieving, then mixed with pungent essential oil compound, finally added
Enter auxiliary material, it is well mixed to produce.
Functional drug of the present invention with genital tract mucosal effect, application method are specific as follows：
During for the sow gestation phase, its addition in feed per ton is 3kg；
During for 1 month before insemination of sows and 1 month after farrowing, its addition in feed per ton is 4kg.
In functional drug formula of the present invention, dihydropyridine, essence compound and Chinese medical extract can influence livestock and poultry
Reproductive Performance, but it is ineffective during exclusive use, three is organically combined, is used cooperatively, collaboration plays a role, and prepares tool
There is the pre-mixing agent that genital tract mucosal acts on, to have the function that to improve livestock and poultry Reproductive Performance.The concrete function effect of each raw material is introduced
It is as follows：
Dihydropyridine：Chemical name is 2,6- dimethyl -3,5- diethyl-ester group-l, 4- dihydropyridines, is that a kind of novel green is more
The feed addictive of function, there is extensive biological function；Such as, conception rate can be effectively improved, improve sow utilization rate, improved
Boar semen quality；And piglet birth weight, weaning weight can be improved；Proteinosis can be increased, improved food conversion ratio simultaneously, had
Effect improves culture benefit；Some hormonal readinesses in serum can be changed, promote animal growth and development, improve reproductive performance and dam
Milking capacity, and strengthen immunologic function, and its metabolism completely, almost noresidue.Other dihydropyridine can significantly increase
The myoelectrical activity of strong small intestine, moves after slowing down digesta into duodenum, is advantageous to small intestine and digests and assimilates, so as to improve efficiency of feed utilization.
Pungent essential oil compound：Plants essential oil is having of being extracted from plant different tissues such as fruit, blade, flower and root
Strong smell and the volatile liquid of fragrance, typically pass through steam distillation, solvent extraction and supercritical CO2The methods of extraction, carries
Take.It is a kind of efficient, safe and stable, controllable plant-derived medicine, and having improves testosterone concentration and sperm work
Power, improve sperm concentration；It is antibacterial, antiviral；Strengthen animal body immunity function, improve anti-stress ability and improve animal productiong
The advantages that performance.
Chinese medical extract：a）Barrenwort：Barrenwort effective component is based on flavonoids, polysaccharide, additionally containing biology
Alkali, lignanoid, leukotrienes, vitamin, grease and trace element manganese, zinc etc..So far find barrenwort have delay kidney failure process,
Strengthen thefunction of male reproduction, regulation body's immunity and other effects.Hypothalamic pituitary gonadal axis is the advanced of genital regulating
Maincenter, barrenwort may act on this advanced regulation and control maincenter, play its effect for promoting reproduction；Barrenwort can promote sex hormone point
Secrete or show gonadotropic Effect, make the increase of cock ovary relative weight, curved fine extract tube diameter increase, it is thin to occur sperm ahead of time
Born of the same parents；Certain protective effect is also shown to sexual organ.b）Semen Cuscutae：Belong to flavone compound, be traditional tonic medicine, there is nourishing
Liver kidney, astringent sperm contracting urine, antiabortive improving eyesight and other effects, menstruation regulating is mainly used in terms of reproduction is adjusted, antiabortive, treatment is infertile etc.
Disease.Wherein contain a variety of the essential trace elements of the human bodys, such as zinc, manganese, iron, also have to thefunction of male reproduction extremely close
Relation.c）Morinda officinalis：Morinda officinalis How is one of China's famous " four great Nan medicines ", containing carbohydrate, iridoid,
A variety of chemical compositions such as anthraquinone analog compound and amino acids.Morinda officinalis can be used for treatment irregular menstruation, cooling infertile；
As traditional kidney-nourishing yang-strengthening medicine, the synthesis of testosterone is can speed up, improves level of serum testosterone；Have to the spermatogenesis of testis
It is obviously promoted effect；Increase sperm sum, improve sperm motility rate, reduce rate of teratosperm, production of sperm is thin to caused by a variety of causes
Born of the same parents, Sperm lesion, there is reparation, protective effect.
Compared to the prior art, the present invention has advantages below：
It is provided by the invention with genital tract mucosal effect functional drug, apply in additive for farm animal feed, avoid with
The drawbacks of being brought toward the method using injection sex hormone, can effectively solve animal reproduction dysfunction, while adjust animal body
The development of reproductive function, hormonal readiness and genital organ, livestock and poultry breeding and childbirth performance are improved, effectively improves culture benefit.
Embodiment
Embodiments of the invention are elaborated below, the present embodiment is carried out lower premised on technical solution of the present invention
Implement, give detailed embodiment and specific operating process, but protection scope of the present invention is not limited to following implementation
Example.
In following embodiments, raw materials used pungent essential oil compound is bought from the limited public affairs of morning twilight biotechnology group share
Department；Chinese medical extract（Shorthorned Epimedium P.E, Semen Cuscutae extract and Radix Morindae Officinalis extract）Buy Anchang high mountain biotechnology westerly
Co., Ltd, Chinese medical extract use supercritical CO2Abstraction technique is carried out, to ensure that the bioactivity of extract is not destroyed.
Embodiment 1
A kind of functional drug with genital tract mucosal effect, is made up of per 100kg functional drugs the raw material of following proportioning：Two
Pyridinium hydroxide 5kg, pungent essential oil compound 1.5kg, Shorthorned Epimedium P.E 0.5kg, auxiliary material DEXTROSE ANHYDROUS 93kg.
The preparation method of the above-mentioned functional drug with genital tract mucosal effect, specifically includes following steps：Take in proportion
Each raw material, first dihydropyridine and Shorthorned Epimedium P.E are crushed, mixed after 150 sieves excessively, then mixed with pungent essential oil compound, most
Auxiliary material DEXTROSE ANHYDROUS is added afterwards, it is well mixed to produce.
Embodiment 2
A kind of functional drug with genital tract mucosal effect, is made up of per 100kg functional drugs the raw material of following proportioning：Two
Pyridinium hydroxide 5kg, pungent essential oil compound 1.5kg, Semen Cuscutae extract 0.5kg, auxiliary material DEXTROSE ANHYDROUS 93kg.
The preparation method of the above-mentioned functional drug with genital tract mucosal effect, specifically includes following steps：Take in proportion
Each raw material, first dihydropyridine and Semen Cuscutae extract are crushed, mixed after 150 sieves excessively, then mixed with pungent essential oil compound, most
Auxiliary material DEXTROSE ANHYDROUS is added afterwards, it is well mixed to produce.
Embodiment 3
A kind of functional drug with genital tract mucosal effect, is made up of per 100kg functional drugs the raw material of following proportioning：Two
Pyridinium hydroxide 5kg, pungent essential oil compound 1.5kg, Radix Morindae Officinalis extract 0.5kg, the anhydrous sucrose 93kg of auxiliary material.
The preparation method of the above-mentioned functional drug with genital tract mucosal effect, specifically includes following steps：Take in proportion
Each raw material, first dihydropyridine and Radix Morindae Officinalis extract are crushed, mixed after 150 sieves excessively, then mixed with pungent essential oil compound, most
The anhydrous sucrose of auxiliary material is added afterwards, it is well mixed to produce.
Application test
The synergy checking test of dihydropyridine and Radix Morindae Officinalis extract；
Dihydropyridine and the excessive leaves of pulse plants of sheep, the synergy checking test of Radix Morindae Officinalis extract.
Test Ration Compound
Experiment daily ration 1 is prepared：3kg dihydropyridines are added in basal diet per ton, are mixed.
Experiment daily ration 2 is prepared：3kg functional drugs of the present invention are added in basal diet per ton, are mixed.The 3kg present invention
Functional drug compound method：Will dihydropyridine 150g and Radix Morindae Officinalis extract 15g crush, cross 150 mesh sieves after mix, then with it is pungent
Essential oil compound 45g is mixed, and is eventually adding 2.79kg DEXTROSE ANHYDROUSs, is well mixed, is produced.
Experiment daily ration 3 is prepared：3kg functional drugs of the present invention are added in basal diet per ton, are mixed.The 3kg present invention
Functional drug compound method：Then dihydropyridine 150g and sheep excessive leaves of pulse plants 7.5g and Radix Morindae Officinalis extract 7.5g are pulverized and mixed uniformly
Afterwards, 150 mesh sieves are crossed, are mixed with pungent essential oil compound 45g, the mixing of 2.79kg DEXTROSE ANHYDROUSs is eventually adding, produces.
Test method
Test and carried out in Henan Province pig farm, colony house was carried out disinfection before on-test and carry out isolation subregion.During experiment
Ensure freely movable in-pig, free feeding, free water.Choose the experiment gestational period that body weight is close, health status is good
Sow totally 120, is divided into four treatment groups：3 groups of blank control group, 1 group of experiment, 2 groups of experiment and experiment, every group 30, if 6
Repeat, it is each to repeat 5.Blank control group only feeds genuine basal diet, does not add any added ingredient；Test 1 group of feeding
Test daily ration 1（Dihydropyridine 3g/kg feeds are added i.e. in basal diet）, experiment 2,3 groups feed above-mentioned experiment day respectively
Grain 2, experiment daily ration 3.Basal diet is conventional gestational period feed for sow.
Interpretation of result
All data first carry out preliminary treatment analysis with Excel, are then counted with SPSS 21.0 One-way ANOVA
To analyze, test data is represented with mean+SD, withP＜ 0.05 is used as significance of difference criterion.As a result see below
Table.
Difference raising formula to Farrowing rate, nest product subnumber, piglet birth weight, weaning weight, per nest number pigs weaned
Influence
From in table, compared with blank control group, 2,3 groups of Farrowing rates of experiment, nest product subnumber, per nest number pigs weaned,
It is significantly increased with piglet birth weight, weaning weight（P ＜ 0.05）, experiment 3 groups it is better；Test 1 group it is each compared with control group
Index has rise trend, but difference is not notable（P ＞ 0.05）.Illustrate ineffective when dihydropyridine individually adds, and this hair
Synergy is played in bright functional drug between each raw material components, significant effect improves.
Claims (4)
1. a kind of functional drug with genital tract mucosal effect, it is characterised in that every 100 parts of functional drugs are by following weight
The raw material composition of part proportioning：4 ~ 6 parts of dihydropyridine, 1 ~ 2 part of pungent essential oil compound, 0.4 ~ 0.6 part of Chinese medical extract, surplus are
Auxiliary material.
2. the functional drug as claimed in claim 1 with genital tract mucosal effect, it is characterised in that the Chinese medical extract
For mixture more than one or both of Shorthorned Epimedium P.E, Semen Cuscutae extract and Radix Morindae Officinalis extract.
3. the functional drug as claimed in claim 1 with genital tract mucosal effect, it is characterised in that the auxiliary material is anhydrous
Glucose and/or anhydrous sucrose.
4. the preparation method of any functional drug with genital tract mucosal effect of claims 1 to 3, it is characterised in that
Comprise the following steps：Take each raw material in proportion, first dihydropyridine and Chinese medical extract crushed, mixed after sieving, then with pungent perfume (or spice)
Essential oil compound mixes, and is eventually adding auxiliary material, well mixed to produce.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710958384.1A CN107647139A (en) | 2017-10-16 | 2017-10-16 | A kind of functional drug with genital tract mucosal effect and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710958384.1A CN107647139A (en) | 2017-10-16 | 2017-10-16 | A kind of functional drug with genital tract mucosal effect and preparation method thereof |
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| Publication Number | Publication Date |
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| CN107647139A true CN107647139A (en) | 2018-02-02 |
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| CN201710958384.1A Pending CN107647139A (en) | 2017-10-16 | 2017-10-16 | A kind of functional drug with genital tract mucosal effect and preparation method thereof |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101491298A (en) * | 2008-12-17 | 2009-07-29 | 天津瑞普生物技术股份有限公司 | Additive combination capable of prolonging production-peak duration time of layer |
| CN104522424A (en) * | 2014-12-30 | 2015-04-22 | 青岛七好营养科技有限公司 | Compound additive for improving breeding capacity of male mink and preparation method of compound additive |
| CN105248888A (en) * | 2015-11-26 | 2016-01-20 | 山东绿都安特动物药业有限公司 | Feed additives for improving reproductive performance of breeding fur-bearing animals |
| CN105288021A (en) * | 2015-09-16 | 2016-02-03 | 四川伴农动保生物技术有限公司 | Estrus stimulating powder and preparation method thereof |
-
2017
- 2017-10-16 CN CN201710958384.1A patent/CN107647139A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101491298A (en) * | 2008-12-17 | 2009-07-29 | 天津瑞普生物技术股份有限公司 | Additive combination capable of prolonging production-peak duration time of layer |
| CN104522424A (en) * | 2014-12-30 | 2015-04-22 | 青岛七好营养科技有限公司 | Compound additive for improving breeding capacity of male mink and preparation method of compound additive |
| CN105288021A (en) * | 2015-09-16 | 2016-02-03 | 四川伴农动保生物技术有限公司 | Estrus stimulating powder and preparation method thereof |
| CN105248888A (en) * | 2015-11-26 | 2016-01-20 | 山东绿都安特动物药业有限公司 | Feed additives for improving reproductive performance of breeding fur-bearing animals |
Non-Patent Citations (2)
| Title |
|---|
| 傅胜才等: "《新编兽药手册》", 30 June 2011, 湖南科学技术出版社 * |
| 周选武等: "饲粮添加抗生素和植物精油对母猪生长性能、免疫功能和乳成分的影响", 《动物营养学报》 * |
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Application publication date: 20180202 |
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