CN107638521A - A kind of liver protection is dispelled the Chinese medicine composition and preparation method thereof of wine - Google Patents
A kind of liver protection is dispelled the Chinese medicine composition and preparation method thereof of wine Download PDFInfo
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Abstract
The invention provides a kind of raw material dispelled the Chinese medicine composition of wine for liver protection, include following parts by weight：Seabuckthorn fruit powder：85 120 parts, kudzu-vine root powder：32 65 parts, lophatherum gracile powder：18 55 parts, taurine powder：8 25 parts, vitamin c powder：13 37 parts.
Description
Technical field
Dispelled the present invention relates to food, field of health care products, more particularly to liver protection Chinese medicine composition of wine and preparation method thereof.
Background technology
China is a country with deep spirits culture, and wine turns into national and carries out the indispensable work of social activities already
Tool.Alcohol absorbs from intestines and stomach quickly enters blood, 100% can be absorbed in two hours.Liver is the main of metabolism alcohol
Organ, the alcohol dehydrogenase (ADH) that alcohol passes through in liver are catalyzed and generate acetaldehyde, and acetaldehyde takes off through the acetaldehyde in liver mitochondrion
Hydrogen enzyme (ALDH) is further oxidized to nontoxic acetic acid, ultimately generates carbon dioxide and energy.
However, the speed of liver oxidative metabolism alcohol is very slow, heavy drinking can cause the concentration of alcohol in blood drastically to rise
Height, cause acute alcoholism i.e. drunk.After acute alcoholism, the discomfort of long period can be caused, the long period occur
Have a headache, be dizzy, have a sleepless night, be weak, trembling, having a stomach upset and be nauseous, or even showing as hyponea.Long-term excessive consumption of alcohol, liver
Accumulation of poisoning easily occurs, causes stem cell alcohol to be denatured, and then develops into fatty liver, hepatic sclerosis even liver cancer.Alcoholic liver
Infringement has become one of main reason of chemical damage.
The incidence of China's adult's alcoholism is at a relatively high, and long-term alcohol can cause the damage, especially right of whole body multisystem
Intestines and stomach, hepar damnification become apparent, and alcohol can directly or indirectly cause chronic gastritis, peptic ulcer and alcoholic-toxic liver
Hardening.Therefore, the medicine for studying Antialcoholic liver-protecting has important social effect in today that spirituosity drink increasingly spreads unchecked.
The content of the invention
It is an object of the invention to provide a kind of original dispelled the Chinese medicine composition of wine for liver protection, include following parts by weight
Material：Seabuckthorn fruit powder：85-120 parts, kudzu-vine root powder：32-65 parts, lophatherum gracile powder：18-55 parts, taurine powder：8-25 parts, vitamin c powder：
13-37 parts.
Preferably, the seabuckthorn fruit powder is 95-108 parts, the kudzu-vine root powder is 43-55 parts, the lophatherum gracile powder is 30-40
Part, the taurine powder are 12-21 parts, the vitamin c powder is 19-30 parts.
Preferably, the seabuckthorn fruit powder is 100 parts, the kudzu-vine root powder is 50 parts, the lophatherum gracile powder is 35 parts, the ox sulphur
Sour powder is 15 parts, the vitamin c powder is 25 parts.
The present invention also provide it is a kind of for liver protection dispel wine Chinese medicine composition preparation method, comprise the following steps：
(1) preparation of seabuckthorn fruit powder：Fructus hippophae is gone into the removal of impurity, cleaned up, removes its carpopodium flower pedicle, adds water, is crushed
Mashing, the extruding of gained sea-buckthorn pulp is taken into juice and filters off residue, is dried after the filtered concentration of gained juice, seabuckthorn fruit powder is made；
Preferably, water described in step (1) is purified water, and the weight of the purified water is 2-5 times of fructus hippophae；It is described net
The temperature for changing water is 50-70 DEG C.
Preferably, water described in step (1) is purified water, and the weight of the purified water is 3 times of fructus hippophae；The purification
The temperature of water is 60 DEG C.
Preferably, crushing and beating described in step (1) uses the beater that screen-aperture is 0.6-1.0 millimeters.
Preferably, crushing and beating described in step (1) uses the beater that screen-aperture is 0.8 millimeter.
(2) preparation of kudzu-vine root powder：500 kilograms of root of kudzu vine raw material is taken, goes the removal of impurity, water is drained twice for rinsing, is dried, and is crushed,
Root of kudzu vine raw material throws tank, and gas heating extraction, extract solution filtering storage are opened in ethanol extraction, and outer circulation is concentrated under reduced pressure, is spray-dried, powder
Broken, sieving.
Preferably, gas heating extraction is opened described in step (2) as circulation extraction 3 times, 1.5 hours every time, i.e., is followed within 30 minutes
Ring is once.
Preferably, the outer circulation temperature that is concentrated under reduced pressure is spent for 60 degree -70 in step (2), and medicinal extract proportion 1.25, alcohol precipitation 24 is small
When, supernatant concentration is taken, proportion 1.15, sediment is standby.
(3) preparation of lophatherum gracile powder：100 kilograms of lophatherum gracile is weighed, the lophatherum gracile weighed up is gone into the removal of impurity, cleaned up,
Raw material throws tank, ethanol extraction, opens gas heating extraction, extract solution filtering storage, and circulation is concentrated under reduced pressure, separation sedimentation, spray drying,
Crush, sieving.
(4) taurine powder is taken；
(5) vitamin C is taken；Preferably, the vitamin C is powdered.
(6) above-mentioned five kinds of raw materials are loaded in mixing machine according to the above ratio, fully mixed, cobalt 1 is irradiated and gone out after pack
Bacterium, kept dry.
Preferably, the step (6) is further comprising the steps of：
A) lophatherum gracile powders of the parts by weight, seabuckthorn fruit powder, kudzu-vine root powder, taurine powder, vitamin c powder are weighed, it is standby；
B) lophatherum gracile powder weighed up, seabuckthorn fruit powder, kudzu-vine root powder, taurine powder, vitamin c powder are added water to cook together it is secondary,
For the first time plus 10 times of water is measured, and is decocted 2 hours, second plus 8 times of amounts of water, decoction 1 hour, is merged extract solution, filtration, is added ethanol extremely
Alcohol content is 65%, is stirred, and refrigeration is stood, and filtration, decompression filtrate recycling ethanol extremely without alcohol taste and is concentrated into thick paste；
C) above-mentioned thick paste is dried, crushed, obtain the active component of medicine of the present invention.
(7) prepared by finished product：The name of an article of material, lot number, quantity, chemical examination odd numbers etc. are first checked before preparing, after confirmation is errorless again
Carry out in next step.Medicine prepared by step (6) and pharmaceutically acceptable auxiliary material are mixed and made into any preparation.
Preferably, medicine prepared by step (6) and pharmaceutically acceptable auxiliary material are mixed and made into oral formulations, the mouth
Formulation includes but is not limited to pill, powder, tablet, lozenge, capsule, oral liquid.It is directly to make that solid pharmaceutical preparation, which is wherein made,
With plant extracts (i.e. the present invention obtained active constituents of medicine), in order to carry and take；It is by institute that liquid preparation, which is made,
State the active constituents of medicine that the present invention obtains to blend in water, be easy to human body to utilize and absorb, work faster.
Preferably, it is tablet or capsule that the present invention, which is used for the dispel formulation of Chinese medicine composition of wine of liver protection, wherein being made
Capsule selects No. 1 mechanical irrigation preparation shell, and with the filling above-mentioned plant extracts prepared of preparation bottle placer, 0.3 gram/is adopted again
With aluminum-plastic packaged, plastic-aluminum packing plate, with being fitted into polybag, finally adds outer packing, finished product is made with small desiccant bag.
Preferably, the present invention is used for the dispel Chinese medicine composition of wine of liver protection and may be made as liquid preparation, wherein the oral liquid
The loading amount of Agitation Tank is usually no more than the 4/5 of the tank total capacity, specially that the above-mentioned plant extracts prepared is (i.e. of the invention
The active component of medicine) to blend in water, decoction adds purified water to be sufficiently stirred 30 minutes to finite concentration and be allowed to well mixed, so
PH, the content of semi-finished product are detected afterwards, and packing is supplied after qualified.
The invention reside in the Chinese medicine composition for providing a kind of liver protection and dispelling wine, each efficacy of drugs is produced these drug regimens
Raw synergy, have obvious liver protection dispel wine the effect of, there is the effect of dispelling wine nourishing.
It should be appreciated that foregoing description substantially and follow-up description in detail are exemplary illustration and explanation, should not
As the limitation to the claimed content of the present invention.
Brief description of the drawings
With reference to the accompanying drawing enclosed, the present invention more purpose, function and advantages will pass through the as follows of embodiment of the present invention
Description is illustrated, wherein：
Fig. 1 is blank control group mouse liver organization chart；
Fig. 2 is positive controls mouse liver organization chart；
Fig. 3 is that liver protection is dispelled wine low dose group mouse liver organization chart；
Fig. 4 is that liver protection is dispelled wine middle dose group mouse liver organization chart；
Fig. 5 is that liver protection is dispelled wine high dose group mouse liver organization chart.
Embodiment
By reference to one exemplary embodiment, the purpose of the present invention and function and the side for realizing these purposes and function
Method will be illustrated.However, the present invention is not limited to one exemplary embodiment as disclosed below；Can by multi-form come
It is realized.The essence of specification is only to aid in the detail of the various equivalent modifications Integrated Understanding present invention.
Hereinafter, embodiments of the invention will be described with reference to the drawings.In the accompanying drawings, identical reference represents identical
Or similar part, or same or like step.
Dispelled the invention provides a kind of liver protection the Chinese medicine composition of wine, affiliated preparation includes following compositions：Seabuckthorn fruit powder：
85-120 parts, kudzu-vine root powder：32-65 parts, lophatherum gracile powder：18-55 parts, taurine powder：8-25 parts, vitamin c powder：13-37 parts.Will
These drug regimens cause each efficacy of drugs to produce synergy, reach liver protection and dispel the purpose of wine.
Wherein seabuckthorn fruit powder is yellow by sea buckthorn fruit powder, sea buckthorn fruit Quercetin containing flavonoid, Isorhamnetin, tetrahydroxy
Ketone and its glycosides, and containing vitamin C, vitamin E, carrotene, vitamin B1, vitamin B2, vitamin B6, vitamin B12With
Folic acid；Institute's fatty acids have myristic acid, palmitoleic acid, palmitic acid, stearic acid and oleic acid, linoleic acid, elaidic acid, anti-sub- oil
Acid, arachidonic acid, laurate etc.；Additionally contain a variety of organic acids, saponin(e, sterol, carbohydrate and 15 kinds of trace elements.
Sea-buckthorn has following physiological function：
(1) liver and digestive system are protected
20% g kg of sea buckthorn juice 0.84 and 1.68 g kg body weight are to CCL4, paracetamol induced mice damage
Increasing for MDA (MDA) has obvious inhibiting effect in liver, and can significantly reduce CCL4The SGPT vigor of poisoning mice, confrontation are flutterred
The exhaustion of heat breath pain poisoning mice liver glutathione (GSH).The g kg of Seabuckthorm Seed Oil 0.25 and 0.5 g kg weight gavage, can
Significantly reduce CCL4Caused by necrosis region in liver.Electron microscopic observation, CCL4Group rough surfaced endoplasmic reticulum (RER) changes, i.e., small in liver cytoplasm
Sheet basophilla material largely disappears, and Seabuckthorn Oil can be such that the material recovers to normal level.Seabuckthorn Oil can be also resisted by CCL4
The dysbolisms such as the metabolism of caused liver cell, sugar synthesize, glycogen solidification, protein synthesis.Seabuckthorn Oil can prevent that liver is thin
Born of the same parents P450 reduction, prevented also from the reduction of total protein in liver and water-solubility protein, and by ethanol and CCl4The cell risen
Matter and microsome, the reduction of hepatic protein.In addition, Seabuckthorn Oil intraperitoneal injection has lipotropic effect, and it is chloro- to 3,4-
The liver plasma membrane of 1- butylene slow poisoning rats has stabilization.
Neutral lipid composition in Seabuckthorn Oil and seabuckthorn fruit powder has very strong antiulcer action, has to reserpine institute Ulceration
Notable antagonism.The healing of gastric ulcer and damage of intestines can be accelerated, stomach lining MDA is reduced and improve neutral amino
The concentration of acid.In addition, Seabuckthorn Oil and seabuckthorn fruit powder can make animal saliva and stomach and intestine glandular secretion increase, pepsin content rise.
There are stimulation, Rythmic contractions characteristic cycle stretch-out, amplitude increase to gastrointestinal motility function simultaneously.
(2) free radical is removed
Stimulate polymorphonuclear human leukocytes (PMN) raw PMA when containing 1.7 milligrams of total seabuckthorn flavones in every milliliter of sea-buckthorn solution
Into active oxygen radical have obvious scavenging action, when the total seabuckthorn flavone of milligram containing 0.03-3 in every liter of sea-buckthorn solution to yellow fast
The active oxygen radical of purine/Huang Piao Ling oxidase systems has the scavenging action of notable dose dependent, but riboflavin is produced
The scavenging action of liveliness proof oxygen radical is weaker.Fenton is reacted when containing the milligram hour of total seabuckthorn flavone 3 in every liter of sea-buckthorn solution
The HO of generation has obvious scavenging action, and multinuclear people can also be significantly inhibited when containing 1 milligram of total seabuckthorn flavone in every liter of sea-buckthorn solution
Luminescent activity caused by leucocyte.
Mouse is injected intraperitoneally the mg/kg body weight of Seabuckthorn Oil 2.5, Wheat Protein and prevents fatty liver from making
With, and lipid peroxidation speed and Vitamin E levels in tissue can be adjusted.Seabuckthorn Oil is similar to vitamin E, and Hyperlipidemic Serum is damaged
The vascular smooth muscle cells of wound have protective effect, can substantially reduce elevated MDA in high fat damage smooth muscle cell
(LOP) content, and SOD activity can be significantly improved, so as to mitigate damage of the Hyperlipidemic Serum to cell membrane, protect and promote thin
The healthy growth of born of the same parents.
(3) it is antifatigue and other
Seabuckthorn fruit powder is rich in vitamin C and various trace elements, has desirable influence to dispelling fatigue and enhancing locomitivity,
It also can significantly improve cardiac function.The mg/kg body weight of mouse peritoneal injection total seabuckthorn flavone 2, continuous 6 days, body weight had a net increase of
Add apparently higher than control group.
Heavy dose of sea-buckthorn concentrate can be obviously prolonged the time of yellow Jackets induced mice sleep.Seabuckthorm Seed Oil can show
Write the activity for suppressing monoamine oxidase in mouse brain.
Other sea-buckthorn also has enhancing immune, improves cardiovascular system and hemopoietic system function, and anti-tumor radiation
With the function such as anti-inflammatory.The seabuckthorn fruit powder that the present invention uses is prepared using vanguard technology, effectively saves sea-buckthorn
Contained all functional components in fruit, therefore possess various functions described above.
Wherein kudzu-vine root powder has root of kudzu vine powder, and kudzu root extract is the rhizome of the root of kudzu vine, rattan and spends whole extractions, and active ingredient is
Kudzu root flavone.
The physiological function of the root of kudzu vine：
(1) it is medicinal：Conventional use is soaked to be drunk, and goes out impermeable, acute stomach for treatment cold, fever, thirsty, headache Xiang Qiang, rash
Enteritis, baby diarrhea, intestinal obstruction, dysentery, hypertension, angina pectoris, sudden deafness, coronary heart disease, diabetes, liquor-saturated, enhancing of sobering up
Child development and intelligence etc. all have positive role.
(2) sober up：Alcohol fast decoupled and excretion can be promoted by drinking after drinking, so as to sober up rapidly, mitigate liver pressure.Tool
There is the function that removing toxic substances is amusing.Property sweet taste, be apt to relieving alcoholism, be amusing and stomach quench one's thirst, cure mainly insobriety headache and dizziness, polydipsia is vomitted
Tell, the disease such as chest diaphragm is glutted.《Treatise on the spleen and stomach》There is flower of kudzuvine to neutralize the effect of alcoholic drinks (hangover：It is clouded in mind after liquor-saturated) soup,《The southern regions of the Yunnan Province book on Chinese herbal medicine》There is flower of kudzuvine pill for clearing away heat
Deng treating drunk.In addition, (the kind flower of kudzuvine of Pueraria lobota dries flower for legume Pueraria lobota by the root of kudzu vine, Ge Gu.Activating spleen by relieving alcoholism.For drinking
Degree, headache, dizzy, polydipsia, chest diaphragm is glutted, and acid regurgitation etc. injures the disease of stomach Qi.
(3) beauty：Kudzu root flavone has cancer-resisting and estrogen-like action, can promote women beauty treatment, especially to the middle age
Women and the effect of menopausal women face-nourishing health-care are obvious.
Wherein lophatherum gracile powder is by lophatherum gracile powder, and lophatherum gracile is grass family, lophatherum gracile category herbaceos perennial, root shape
Stem.It can be expanded for spindle-like meat root tuber, yellow-white in the middle part of fibrous root.Leaf lanceolar, panicle；Caryopsis ellipse.It is born in mountain
The dark and damp place of slope sylvan life.It is distributed in each provinces and regions on the south the Changjiang river.
The physiological function of lophatherum gracile：
Root is medicinal, there is refrigerant, antipyretic, diuresis and the effect hastened parturition；Cure mainly:In the heart disease heat, cough with dyspnea, haematemesis, heat toxin wind,
Only quench one's thirst, press borax poison, dissolving phlegm, control fanatical unhappy, apoplectic aphasia in silence, pain intermittent headache, stop palpitate with fear, pestilence fan are vexed, kill small worm, remove
The slow spleen of heat.Herbage can be made again.
Functional component contained by lophatherum gracile is mainly：The micro member such as flavones, phenolic acid compound, amino acid, manganese, zinc
Element.Experiment shows：These active ingredients can remove activity in vivo oxygen radical (it can promote people's aging)；Induce inside organism
Antioxidant Enzymes activity；Strengthen the resisting stress and anti-fatigue ability of body；Improve memory capability, the process of anti-aging
Deng.In addition, also containing abundant chlorophyll in lophatherum gracile.Research shows that chlorophyll is the important of many vegetables antimutagenesises
Composition, there is antitumor anti-canceration effect, because chlorophyll has stronger anti-oxidation function, this is sick to prevention of cardiovascular and anti-aging
There is positive role.So lophatherum gracile function factor is alternatively arranged as out in addition to available for old functional food and antioxidant food
Some ingredient origins for treating common difficult medicine are sent out, as cardiovascular and cerebrovascular protects medicament, antineoplastic etc..Meanwhile the leaf of bamboo
It will also fully develop talents in the exploitation of health products, functional beverage etc..
The physiological function of taurine：
(1) infant brain tissue and intelligence development are promoted
Taurine in the rich content, widely distributed of intracerebral, can be obviously promoted nervous system grow and cell increases
Grow, break up, and be in dose dependent, played an important role in cranial nerve cell growth course.Research shows:In premature's brain
Content of taurine is significantly lower than term infant, because the cysteine sulfinic acid dehydrogenase (CSAD) in premature's body is not yet sent out
It is bred as ripe, synthesizing taurine is insufficient for the needs of body, need to be supplemented by breast milk.Content of taurine in breast milk is higher, especially
Content is higher in its colostrum.If supplement deficiency, it will make physical growth of children develop slow, MR.Taurine and children
The development of youngster, the nervous centralis of fetus and retina etc. has close relationship, and long-term simple milk is fed, and easily causes taurine
Shortage.
(2) nerve conduction and visual function are improved
Why cat and night flight or navigation cat owl will prey on mouse, and its main cause is containing abundant ox sulphur in mouse body
Acid, more foods can keep its sharp keen vision.If infant lacks taurine, it may occur that retinal function is disorderly.Long-term is quiet
The patient of arteries and veins nutrition infusion, if there is no taurine in transfusion, patient's retina map of current can be made to change, only supplement big agent
The taurine of amount could correct this change.
(3) cardiovascular disease is prevented
Taurine can suppress platelet aggregation in the circulatory system, reduce blood fat, keep human normal blood pressure and anti-stop
Arteries and veins hardens；There is protective effect to cardiac muscle cell, can anti-arrhythmia；There is special efficacy to reducing blood cholesterol level, can
Treat heart failure.
(4) absorption of lipid is influenceed
The effect of taurine is to combine to form cholyltaurine with bile acid in liver, and taurocholate is to lipid in alimentary canal
Absorption is required.Taurocholate can increase the dissolubility of lipid and cholesterol, release cholestasia, reduce some free bile
The cytotoxicity of acid, suppress the formation of cholesterol stone, increase bile flow etc..
(5) improve endocrinosity, strengthen human immunity
Taurine can promote pituitary hormone secretion, activate pancreas function, right so as to improve the state of organism endocrine system
Organism metabolism is with beneficial regulation；And have the function that promote organism immunity enhancing and it is antifatigue.
(6) glycometabolism is influenceed
Taurine can be combined with insulin receptor, promoted cellular uptake and using glucose, accelerated glycolysis, reduce blood glucose
Concentration.Research shows that taurine has certain hypoglycemic effect, and independent of the release of increase insulin.Taurine pair
The adjustment effect of cell glucose metabolism may be by what mechanism after acceptor was realized, and it relies primarily on the phase with insulin receptor protein
Interaction, rather than want material taurine concentration then substantially to reduce, antioxidation weakens, and the protein in crystal occurs excessive
Oxidation, so as to cause or aggravate the generation of cataract.Supplementation of taurine can suppress the occurrence and development of cataract.
(7) function of memory is improved
In taurine with being found in the animal experiment study of brain growth relation, taurine can promote study and the note of big white mouse
Recall ability.Learning and memory speed can not only be improved by supplementing appropriate taurine, but also can improve the accuracy of learning and memory,
And also there is certain effect to the anti-aging of nervous system.
(8) normal reproductive function is maintained
Normal reproductive function needs to be maintained with taurine.There is a data confirmation, content of taurine is less than in cat feed
When 0.101%, its reproductive function is bad, and stillborn foetus, miscarriage and birth defect rate increase, and pup survival rate declines.Containing 0.105% with
When upper, normal reproductive function could be maintained.
(9) other functions
Taurine preventing and treating hypoferric anemia has positive effect, and it can not only promote absorption of the enteron aisle to iron, can also increase
The stability of erythrocyte membrane；The growth-promoting factors of bifid bacterium in taurine or human body intestinal canal, optimize bacterium group structure in enteron aisle；Also
With anti-oxidant, delaying senility function；Oxyhepatitis can be promoted to recover normal；There is protective effect to carbon tetrachloride poisoning, and
The rise of thus caused serum glutamic pyruvic transminase can be suppressed.There is protective effect to renal toxicity, taurine is to caused by cis-platinum
The primary renal cells of rabbit, which changes, protective effect；Taurine can calm, analgesia and anti-inflammatory, to frostbite, KCN poisonings and partially
Headache also has preventive and therapeutic effect.
Ascorbic physiological function：
(1) redox
In vivo, vitamin C/DHVC redox reaction and sulfydryl (- SH)/cystine linkage (- S-S) system
It is associated.Therefore vitamin C can make in vivo-SH is horizontal to improve.Vitamin C may play the role of to remove free radical in vivo, have
A little infringements of the chemical substance to body, are directed to the effect of free radical, such as oxygen, ozone, nitrogen dioxide, alcohol, carbon tetrachloride
And damage of the Aclacnomycin A Hydrochloride in anticarcinogen to heart.Vitamin C can resist as internal water miscible antioxidant with fat-soluble
Oxidant has synergy, may be played a role on lipid peroxidation is prevented, crystal of human eye in the presence of light,
Also O can be produced2Free radical, may be cataract Producing reason.These free radicals are under normal circumstances to be anti-oxidant in vivo
Agent such as vitamin C, the sweet peptide of wheat Guang are removed, so substantial amounts of vitamin C can prevent the destruction of this peroxidation.
(2) Vitamin C effect some drugses are metabolized
1. influence of the vitamin C to hepatomicrosome enzyme system；Some fat-soluble medicines under hepatomicrosome enzyme systemic effect,
Carry out carboxylated and remove four bases, after turning into polar compound, be easy to discharge removing toxic substances from bile and urine.Organochlorine insecticide energy
Hair microsomal enzyme vigor thoroughly.But this enzyme system reacts sharper to vitamin situation.The degree of hypovitaminosis C is not yet
When reaching Body weight loss, the vigor of hydroxylase system has declined in microsome, wherein with the reduction of cytochrome reductase most
It is more, about subtract 85%, after replenishing vitamins C, vitamin C amount is recovered normal within a short period of time in tissue, but enzyme activity recover compared with
Slowly.
2. vitamin C also has the carcinogenesis for going histamine to act on and prevent benzidine, naphthylamines and nitrosonium salts.
It is used to liver protection by the following examples the present invention is expanded on further dispel the Chinese medicine composition and preparation method thereof of wine：
The present invention of embodiment 1 be used for liver protection dispel wine Chinese medicine composition oral liquid preparation
Preparation process is as follows：
(1) preparation of sea-buckthorn：
Choose fresh, good, full maturity, be wherein mingled with branches and leaves in orange-yellow or salmon pink fructus hippophae, artificial removal
The impurity such as soil rock, are cleaned up with clear water, wash away the silt adhered to thereon, worm's ovum etc., and the sea-buckthorn cleaned up is trimmed
Its carpopodium flower pedicle etc. is removed, adds the purified water that 3 times of weight are 60 DEG C, beater is equably sent into and carries out crushing and beating, fight
The screen-aperture of machine should be in 0.8 millimeter, and gained sea-buckthorn pulp carries out extruding with spiral juice extractor and takes juice and filter off residue,
After the extruding gained filtered concentration of juice, using vacuum and low temperature thousand dry methods of spraying, seabuckthorn fruit powder is made.
(2) preparation method of kudzu-vine root powder：Expanding treatment, the expanding treatment condition are sequentially carried out to root of kudzu vine raw material：It is expanded
80~105 DEG C of temperature, feed water content 2~5%；First ultra-fine grinding；Ultra high pressure treatment obtains the kudzu-vine root powder, described super
HIGH PRESSURE TREATMENT is specially to be placed in after the material after crushing is packed in pressure conduction medium, and the pressure conduction medium is to institute
State the material after crushing and apply pressure；The ultra high pressure treatment condition：300~600MPa of pressure, 15~30 minutes dwell times.
(3) lophatherum gracile of the parts by weight is weighed, the lophatherum gracile weighed up is added water to cook, merges extract solution, is filtered, filter
Liquid is concentrated into finite concentration, alcohol precipitation, stirs, and refrigeration is stood, and filtration, decompression filtrate recycling ethanol extremely without alcohol taste and is concentrated into
Thick paste；Above-mentioned thick paste is dried, crushes, obtains lophatherum gracile powder.
(4) taurine:Commercially available taurine powder
(5) vitamin C pulvis：Commercially available pharmaceutical grade vitamin c powder；
(6) above-mentioned five kinds of raw materials are loaded in mixing machine according to the above ratio, fully mixed, cobalt 1 is irradiated and gone out after pack
Bacterium, kept dry.
Wherein, the weight of material component is in above-mentioned five：
Seabuckthorn fruit powder double centner
50 kilograms of kudzu-vine root powder
35 kilograms of lophatherum gracile powder
15 kilograms of taurine powder
25 kilograms of vitamin c powder
Wherein, the step (6) is further comprising the steps of：
A) lophatherum gracile powders of above-mentioned parts by weight, seabuckthorn fruit powder, kudzu-vine root powder, taurine powder, vitamin c powder are weighed, it is standby；
B) lophatherum gracile powder weighed up, seabuckthorn fruit powder, kudzu-vine root powder, taurine powder, vitamin c powder are added water to cook together it is secondary,
For the first time plus 10 times of water is measured, and is decocted 2 hours, second plus 8 times of amounts of water, decoction 1 hour, is merged extract solution, filtration, is added ethanol extremely
Alcohol content is 65%, is stirred, and refrigeration is stood, and filtration, decompression filtrate recycling ethanol extremely without alcohol taste and is concentrated into thick paste；
C) above-mentioned thick paste is dried, crushed, obtain the active component of medicine of the present invention.
(7) prepared by finished product：After the first confirmation such as the name of an article of verification material, lot number, quantity, chemical examination odd numbers is errorless before preparing again
Carry out in next step.The loading amount of oral liquid Agitation Tank is usually no more than the 4/5 of the tank total capacity.This hair that step (6) is prepared
The active component of bright medicine is blent in water, and decoction adds purified water to be sufficiently stirred 30 minutes to finite concentration and be allowed to well mixed, so
PH, the content of semi-finished product are detected afterwards, and packing is supplied after qualified.
The present invention provides a kind of Chinese medicine composition oral liquid for wine of being dispelled for liver protection, and instructions of taking is each one before and after drinking
Branch.Chinese medicine composition of the present invention can substantially increase the activity of internal alcohol dehydrogenase, have preferable antialcoholism function.
The present invention of embodiment 2 be used for liver protection dispel wine Chinese medicinal composition capsules agent preparation
(1) preparation of seabuckthorn fruit powder：
Choose fresh, good, full maturity, be wherein mingled with branches and leaves in orange-yellow or salmon pink fructus hippophae, artificial removal
The impurity such as soil rock, are cleaned up with clear water, wash away the silt adhered to thereon, worm's ovum etc., and the sea-buckthorn cleaned up is trimmed
Its carpopodium flower pedicle etc. is removed, adds the purified water that 3 times of weight are 60 DEG C, beater is equably sent into and carries out crushing and beating, fight
The screen-aperture of machine should be in 0.8 millimeter, and gained sea-buckthorn pulp carries out extruding with spiral juice extractor and takes juice and filter off residue,
After the extruding gained filtered concentration of juice, using vacuum and low temperature thousand dry methods of spraying, seabuckthorn fruit powder is made.
(2) preparation of kudzu-vine root powder：Expanding treatment, the expanding treatment condition are sequentially carried out to root of kudzu vine raw material：Swelling temperature
80~105 DEG C, feed water content 2~5%；First ultra-fine grinding；Ultra high pressure treatment obtains the kudzu-vine root powder, the super-pressure
Processing is specially to be placed in after the material after crushing is packed in pressure conduction medium, and the pressure conduction medium is to the powder
Material after broken applies pressure；The ultra high pressure treatment condition：300~600MPa of pressure, 15~30 minutes dwell times.
(3) lophatherum gracile of the parts by weight is weighed, the lophatherum gracile weighed up is added water to cook, merges extract solution, is filtered, filter
Liquid is concentrated into finite concentration, alcohol precipitation, stirs, and refrigeration is stood, and filtration, decompression filtrate recycling ethanol extremely without alcohol taste and is concentrated into
Thick paste；Above-mentioned thick paste is dried, crushes, obtains lophatherum gracile powder.
(4) taurine powder:Commercially available taurine powder
(5) vitamin C pulvis：Commercially available pharmaceutical grade vitamin c powder；
(6) above-mentioned five kinds of raw materials are loaded in mixing machine according to the above ratio, fully mixed, cobalt 1 is irradiated and gone out after pack
Bacterium, kept dry.
Wherein, the weight of above-mentioned five kinds of material components is：
95-108 kilograms of seabuckthorn fruit powder
43-55 kilograms of kudzu-vine root powder
30-40 kilograms of lophatherum gracile powder
12-21 kilograms of taurine powder
19-30 kilograms of vitamin c powder
Wherein, step (6) is further comprising the steps of：
A) lophatherum gracile powders of above-mentioned parts by weight, seabuckthorn fruit powder, kudzu-vine root powder, taurine powder, vitamin c powder are weighed, it is standby；
B) lophatherum gracile powder weighed up, seabuckthorn fruit powder, kudzu-vine root powder, taurine powder, vitamin c powder are added water to cook together it is secondary,
For the first time plus 10 times of water is measured, and is decocted 2 hours, second plus 8 times of amounts of water, decoction 1 hour, is merged extract solution, filtration, is added ethanol extremely
Alcohol content is 65%, is stirred, and refrigeration is stood, and filtration, decompression filtrate recycling ethanol extremely without alcohol taste and is concentrated into thick paste；
C) above-mentioned thick paste is dried, crushed, obtain the active component of medicine of the present invention.
(7) prepared by finished product：The first confirmation such as the name of an article of verification material, lot number, quantity, chemical examination odd numbers is errorless before preparing.Selection 1
Number mechanical irrigation preparation shell, with the activity of the medicine of the present invention prepared in the filling above-mentioned steps (6) prepared of preparation bottle placer
Composition, for 0.3 gram/again using aluminum-plastic packaged, plastic-aluminum packing plate, with being fitted into polybag, finally adds outsourcing with small desiccant bag
Dress, is made finished product.
The present invention be used for liver protection dispel wine health-care food composition instructions of taking for day usual amounts one time a day, every time 3
Grain.The effect of present invention, which is used for the dispel Chinese medicine composition of wine of liver protection, has the effect of obvious relieving alcoholism and protecting liver, and wine of dispelling nourishes.
It should be noted that：According to the needs of preparation, can contain in medicament word field often in Chinese medicine composition of the present invention
Pharmaceutical excipient punishment, such as：
Solvent, filler, flavor enhancement, disintegrant, adhesive, lubricant, wetting agent, pigment, bulking agent, diluent, increasing
Thick dose etc., any conventional peroral dosage form is prepared into the method for Chinese medicinal of routine, as pill, lozenge, powder, tablet,
Capsule, oral liquid etc..It is oral liquid, capsule or piece that the present invention, which is used for the dispel preferred dosage form of Chinese medicine composition of wine of liver protection,
Agent.
Pharmacological evaluation shows, takes the mouse of Chinese medicine composition of the present invention after continuously to wine 15 days, liver cell
More normal mouse liver cell does not take the mouse of Chinese medicine composition of the present invention continuously to wine 15 days without significant change
Afterwards, then there is obvious alcohol sample lesion in liver cell, illustrates that Chinese medicine composition liver protection effect of the present invention is obvious.
The Chinese medicine composition of a kind of wine of being dispelled for liver protection provided by the invention, in Beijing Disease Prevention and Control Centre's nutrition
It is real that detection has carried out toxicological assessment, healthcare function evaluation, effective component identification, stability and hygiene inspection etc.
Test, all indexs reach examination requirements.Human experimentation also shows that the drug regimen can increase the active right of alcohol dehydrogenase
Alcoholic liver injury has significant protective effect.
The beneficial effect of Chinese fir Chinese medicine composition of the present invention is further verified below by way of test example, these examinations
Test pharmacodynamics test and clinical effect trial that example includes Chinese medicine composition of the present invention.
The method of inspection of functional component, content and functional component is described below
1. functional component
This prescription main composition is general flavone, therefore detects the general flavone in product, taurine, ascorbic contains
Amount, you can reach the purpose of control product quality.
2. content：
Flavones (milligram/100 gram) 740
Taurine (gram/100 grams) 20
Vitamin C (gram/100 grams) 20
3. the method for inspection：
3.1 Vitamin C contents determine：
Meet the general provision of " Pharmacopoeia of People's Republic of China " version in 2015.
3.2 content of taurine determine：
Meet the general provision of " Pharmacopoeia of People's Republic of China " version in 2015.
The assay method of 3.3 general flavones
3.3.1 the preparation of rutin standard liquid
0.0210g rutins standard items are accurately weighed in 100mL volumetric flasks plus methanol dissolves and is settled to scale and shakes up again
Accurate point takes the 5mL solution to be shaken up in 50mL volumetric flasks with methanol dilution to scale.
3.3.2 the foundation of standard curve
It is accurate draw rutin standard liquid 0.00mL, 1.00mL, 2.00mL, 3.00mL, 4.00mL, 5.00mL, 6.00mL,
7.00mL is in magnetic evaporating dish plus 1g Silons are adsorbed in 85 DEG C of water-baths and fling to methanol, is then transferred to chromatographic column and is washed with methanol
After de- flavones is into 25mL colorimetric cylinders plus methanol constant volume to scale shakes up and light absorption value is determined at 360nm wavelength with the micro- of rutin
Gram quantity is abscissa, and light absorption value is that ordinate does standard curve.
Regression equation Y=5.841667E-04+7.889331E-04*X, coefficient R=0.999246.
3.3.3 assay method
5mL health care Chinese medicines preparation is accurately pipetted in magnetic evaporating dish plus 1g Silons are adsorbed in 85 DEG C of water-baths and fling to water
Point then be transferred on chromatographic column with methanol elute flavones into 25mL colorimetric cylinders after with methanol constant volume to scale shake up this liquid in
Light absorption value is determined at 360nm the content of general flavone in sample is calculated (with reed according to the rutin Microgram checked in from standard curve
Fourth meter).
Embodiment 3 activates the experiment in vitro of alcohol dehydrogenase：
Alcohol dehydrogenase activity assay method：A Huo He (vaell＆Hoch) method is strangled using watt, and is detected after slightly improveing
Alcohol dehydrogenase activity.Sodium pyrophosphate buffer solution 1.5ml is added in pipe is determined, after mixing at 25 DEG C, capping incubates 5mn.
Measure pipe after incubation adds alcohol dehydrogenase 0.lml immediately, uses spectrophotometric determination absorbance (A340) after shaking up immediately
Value, later reading every 10s once, METHOD FOR CONTINUOUS DETERMINATION 5mn.Zero point is set up with control tube, the reaction group for being not added with Chinese medicine composition is
Determine the blank control group of alcohol dehydrogenase activity.
Alcohol dehydrogenase activity computational methods：It is plotted against time with A, negates and answer initial linear segment, calculates A340nm/
10s value added, it is 6.2 according to molar extinction coefficients of the NADH at 340nm, calculates the unit of activity of enzyme.ADH activity with
The nanomole number of NADH generations per minute represents.
(activation) rate of suppression calculates：
(activation) rate of suppression (%)={ enzymatic activity is without the enzymatic activity dosing measure group of medicine control group one }/enzymatic activity compares without medicine
Group x100%
Above-mentioned every kind of Chinese medicine experiment is repeated 3 times, and is surveyed experimental data and is represented with x scholar s, is examined using t and carry out statistics
Analysis.
Low dose group as described below is that 0.15g/kg (is 0.15 per kg body weight dosagegTraditional Chinese medicinal components of the present invention
Extract), middle dose group 0.30g/kg, high dose group is 0.45g/kg, daily dosage 5 of being respectively grown up, 10,15 times.
As a result it is as shown in table 1：
The result of table 1 shows：Low dosage liver protection dispel wine oral liquid, high dose liver protection of wine oral liquid, middle dosage liver protection of dispelling is dispelled wine
Oral liquid improves alcohol dehydrogenase activity, and activity ratio is respectively 13.39%, 15.54%, 16.14%, illustrates that liver protection is dispelled wine
Oral liquid has the function that to activate alcohol dehydrogenase activity, and dosage more high ethano dehydrogenase activity ratio is higher.
The liver protection of embodiment 4 is dispelled wine zoopery (1)
Rotating stick test
Mouse is placed on above rotary bar, mouse is in the direction that instinct follows transfer rod to rotate and ceaselessly climbed, and trains 3d, will
Uncoordinated and disabled mouse is moved to eliminate.Calculate residence time of the mouse on rod, experimental method：Mouse is placed on and transported
On the horizontal transfer rod turned, start timing；Mouse the 1st time dropped and the number to be dropped in 2min on transfer rod are recorded, with
This represents its sports coordination ability.Every mouse assay 3 times, prevents mouse from fatigue conditions occur, per minor tick 30min, makes even
Average.
Result of the test is shown in Table 2.
3-4 weeks changes of weight result of each experimental mice of table 2
Note：* represents P compared with blank control group<0.05
As shown in Table 2：Rotating rods method is the detection method compared with the drunk mice behavior obstacle of objective evaluation.In turn-club test
In, to drop for the 1st time the time and number is dropped as observation index.Blank control group mouse does not almost drop in 2min, dives
The volt phase is designated as 120s.The sports coordination ability of model group mouse is decreased obviously, and has conspicuousness compared with Normal group mouse
Difference, the number that drops dramatically increase (P ＜ 0.05).With the drunk time, the dyskinesia of mouse aggravates in progressive.
Grasping clubglass test
Grasping clubglass test XZC -4B type pole-climbing formula fatigue instrument.Bar is made into the lower end of bar from the ground perpendicular to ground during experiment
5cm, upper end are fixed.A wood chip groove is placed in the lower end of bar, is fallen into wherein after being easy to mouse pole-climbing.Animal first carries out pole-climbing instruction
Practice, will not pole-climbing person, give it up.Guided first during experiment in animal 15s by being climbed at the top of bar to the bottom of bar, every training
4 times, and determine the pole-climbing time.
Specific assay method is as follows:Mouse tail is held, its head is placed in downwards at the top of bar, allows it to climb down naturally, uses stopwatch
Record mouse is used as own control from bar top to the time required to falling into wood chip case, to fill the pole-climbing time before wine, filling after drinking 30,
The pole-climbing time is tested during 60min as corresponding poisonous substance experimental group.
The Kunming mouse 50 of health is taken, body weight is (20 ± 2) g, is randomly divided into 5 groups, respectively blank control
Group, positive controls, low dosage liver protection are dispelled wine oral liquid group, and middle dosage liver protection is dispelled wine oral liquid group, and high dose liver protection is dispelled wine mouth
Take liquid group, every group 10, wherein female 5, male 5.Female animals divide cage to feed, and free water is with ingesting.
Test and use itself front and rear matched-pair design, the pole-climbing time before every group of record filling wine as this group of negative control, fills
The pole-climbing time after drinking is as experimental group.Record does not fill the wine pole-climbing time, then observe respectively fill for the 1st time after drinking the 30th, 60min
When the animal pole-climbing time, experiment is repeated 3 times, then animal pole-climbing time when observing the 30th, 60min after the 2nd administration.
Statistic analysis result is shown in Table 3
Table 3
As shown in Table 3, as drunk time, the dyskinesia of mouse aggravate in progressive.But middle dosage is protected after 60min
Liver wine oral liquid effect of dispelling is best, substantially recovered normal.Rotating rods method is compared with the drunk mice behavior obstacle of objective evaluation
Detection method.
The liver protection of embodiment 5 is dispelled wine zoopery (2)
Animal packet：Mouse is randomly divided into six groups, every group 8, male and female half and half, and weigh respectively, body weight control is in 10g
Left and right, numbering, wherein 5 groups are made Models of Acute Alcoholic Liver Injury：That is positive controls, liver protection are dispelled wine oral liquid group, and administration is low
Dosage group, middle dose group, high dose group；Separately blank control group is set as 0 group.Modeling and dosage, 5 in addition to blank control group
Fasting 6h before group animal gavage, the physiological saline to 0.3ml/10g.Mouse presses 56 degree two pots of 0.14m/10g gavages Beijing Red Star
Head；After 20min, (0.15g/kg, 0.3g/kg, 0.45g/kg, respectively adult are daily by basic, normal, high dosage for administration group mouse
Dosage 5,10,15 times) gavage liver protection and dispel wine oral liquid；Positive controls gavage same volume physiological saline；Blank control group is normal
Raising；Successive administration 30d.
Experimental implementation：Experiment fills in first time daily starts timing after drinking, records drunk and number of animals of sobering up (with for the moment
In), calculate rate of sobering up and awake liquor-saturated ratio；Occur the righting reflex positive be considered as it is drunk (animal foot is lain on the back in platform upwards,
30s voluntarily can not climb over body, and person is the positive, otherwise is feminine gender), righting reflex feminine gender, which is considered as, sobers up.Drunk time and when sobering up
Between be designated as tolerance time and recovery time respectively, record the situation of change of an each group mouse weight weekly, mouse surveyed after 30d
The SOD values of LPO values and whole blood；Before experiment, fasting 12 hours, eyeball blood sampling is extractd, detects the LPO values of serum and the SOD of whole blood
Value, puts to death mouse after blood sampling, takes mouse liver to do pathological section.
The LPO of mice serum, the SOD values of whole blood assay method：Lipid peroxidase (LPO), superoxide dismutase
Enzyme (SOD) method as defined in its kit operates.
Hepatic tissue pathology sections observation：Hepatic tissue is taken pictures by doing microscope inspection observation after section.
As a result expression and data analysis：Data analysis is carried out using SPSS11.0 softwares.
As a result following form is seen：
The influence of wine Oral Liquid On Mice body weight 1. liver protection is dispelled
1-2 weeks changes of weight result of each experimental mice of table 4
Note：* * represent P compared with blank control group<0.01* represents P<0.05
3-4 weeks changes of weight result of each experimental mice of table 5
Note：* * represent P compared with blank control group<0.01* represents P<0.05
Table 4, the result of each experimental mice changes of weight of table 5 show, the changes of weight phase with blank control group mouse
Than during raising 30 days, the change of other groups of mouse is less than normal, compared with positive controls mouse, takes liver protection and dispels wine oral liquid
Mouse weight tend to be normal.
The influence of wine Oral Liquid On Mice alcohol tolerance time and recovery time 2. liver protection is dispelled
Each model group mouse alcohol tolerance time of table 6 and recovery time result
Note：* * represent P compared with positive controls<0.01
As seen from Table 6, compared with positive controls, take liver protection dispel wine oral liquid group mouse alcohol tolerance time it is obvious
Lengthen, recovery time substantially shortens, and there were significant differences, and the effect of wherein middle dose group is best.
The influence of the drunk rate of wine Oral Liquid On Mice 3. liver protection is dispelled
Drunk result of each model group mouse of table 7 in same time
As a result show, within a certain period of time, the drunk rate of positive controls mouse is 100%, and liver protection is dispelled wine oral liquid group
Drunk rate substantially reduces, and the wherein drunk rate of middle dose group mouse is minimum, and prompting a certain amount of liver protection to dispel wine oral liquid can be effective
Reduce the drunk rate of mouse.
The influence of wine Oral Liquid On Mice liver L PO values 4. liver protection is dispelled
Each experimental mice liver homogenate LPO values of table 8
Note：Compared with blank control group, * represents P<0.05
As a result show, compared with blank control group, other each group Mouse Liver LPO values rises, compared with positive controls, give
The LPO values of medicine each group substantially reduce, wherein middle high dose group reduces more notable, illustrate that the liver protection oral liquid energy of wine of dispelling effectively reduces
Mouse Liver LPO values.
The influence of wine Oral Liquid On Mice Blood SOD Activity 5. liver protection is dispelled
Each experimental mice whole blood SOD values of table 9
Note：Compared with blank control group, * represents P<0.05
Test result indicates that compared with blank control group, remaining each experimental mice whole blood SOD value reduces, with the positive
Control group is compared, and the SOD values of administration group are significantly increased, and illustrates that liver protection wine oral liquid of dispelling can effectively improve Mouse whole blood
SOD activity.
Each experimental mice liver organization pathological analysis
Fig. 1 is blank control group mouse liver organization chart；
Fig. 2 is positive controls mouse liver organization chart；
Fig. 3 is that liver protection is dispelled wine low dose group mouse liver organization chart；
Fig. 4 is that liver protection is dispelled wine middle dose group mouse liver organization chart；
Fig. 5 is that liver protection is dispelled wine high dose group mouse liver organization chart；
Referring to Fig. 1-Fig. 5, result above shows, after 30d is raised, blank control group mouse, lobuli hepatis structure is normal, liver
Rope is arranged radially centered on central vein, and cell is in polyhedron, and monokaryon, accidental double-core, core is big and round, in cell
Centre；Positive controls mouse, liver cell obvious tumefaction, necrosis, kytoplasm is loose, and diffusivity balloon sample becomes, and kytoplasm apparent number is not
One, the fat drips that differ in size vacuole：Liver protection is dispelled wine oral liquid group mouse, and lobuli hepatis structure is normal, liver rope using central vein as
Center is arranged radially；High dose olive juice group mouse, lobuli hepatis structure is normal, and liver rope is centered on central vein in radiation
Shape arranges, and cell is in polyhedron, and monokaryon, accidental double-core, core is big and round, positioned at cell center；Middle dose group and low dosage olive
Juice group mouse, liver cell structure is normal, has slight haziness, swelling, fat to become, olive juice indicated above can be effectively protected
Murine liver tissue.
With reference to the explanation of the invention disclosed here and practice, other embodiment of the invention is for those skilled in the art
It all will be readily apparent and understand.Illustrate and embodiment is to be considered only as exemplary, of the invention true scope and purport is equal
It is defined in the claims.
Claims (10)
1. a kind of Chinese medicine composition for wine of being dispelled for liver protection, include the raw material of following parts by weight：Seabuckthorn fruit powder：85-120 parts, the root of kudzu vine
Powder：32-65 parts, lophatherum gracile powder：18-55 parts, taurine powder：8-25 parts, vitamin c powder：13-37 parts.
2. the Chinese medicine composition of wine according to claim 1 of being dispelled for liver protection, it is characterised in that：The seabuckthorn fruit powder is 95-
108 parts, the kudzu-vine root powder be 43-55 parts, the lophatherum gracile powder is 30-40 parts, the taurine powder is 12-21 parts, the dimension
Raw plain C powder is 19-30 parts.
3. the Chinese medicine composition of wine according to claim 1 of being dispelled for liver protection, it is characterised in that：The seabuckthorn fruit powder is 100
Part, the kudzu-vine root powder are 50 parts, the lophatherum gracile powder is 35 parts, the taurine powder is 15 parts, the vitamin c powder is 25
Part.
The preparation method of the Chinese medicine composition of wine 4. a kind of liver protection is dispelled, comprises the following steps：
(1) fructus hippophae is gone into the removal of impurity, cleaned up, remove its carpopodium flower pedicle, add water, crushing and beating, by gained fructus hippophae
Slurry extruding takes juice and filters off residue, is dried after the filtered concentration of gained juice, seabuckthorn fruit powder is made；
(2) root of kudzu vine is taken, goes the removal of impurity, water is drained twice for rinsing, is dried, and is crushed, and flower of Radix Puerariae is thrown into tank, ethanol extraction, gas is opened and adds
Heat extraction, extract solution filtering storage, outer circulation are concentrated under reduced pressure, are spray-dried, crush, sieving, obtain kudzu-vine root powder；
(3) lophatherum gracile is weighed, the lophatherum gracile weighed up is gone into the removal of impurity, cleaned up, raw material is thrown into tank, ethanol extraction, gas is opened and adds
Heat extraction, extract solution filtering storage, outer circulation are concentrated under reduced pressure, separation sedimentation, spray drying, crush, sieving, obtain lophatherum gracile
Powder；
(4) taurine powder is taken；
(5) vitamin c powder is taken；
(6) above-mentioned five kinds of raw materials are loaded in mixing machine according to the above ratio, fully mixed, the irradiation sterilization of cobalt 1 after pack, done
Dry preservation；
(7) prepared by finished product：The medicine of above-mentioned preparation and pharmaceutically acceptable auxiliary material are mixed and made into any preparation.
The preparation method of the Chinese medicine composition of wine 5. liver protection according to claim 4 is dispelled, it is characterised in that：In step (1)
The water is purified water, and the weight of the purified water is 2-5 times of fructus hippophae；The temperature of the purified water is 50-70 DEG C.
The preparation method of the Chinese medicine composition of wine 6. the liver protection according to claim 4 or 5 is dispelled, it is characterised in that：Step (1)
Described in water be purified water, the weight of the purified water is 3 times of fructus hippophae；The temperature of the purified water is 60 DEG C.
The preparation method of the Chinese medicine composition of wine 7. liver protection according to claim 4 is dispelled, it is characterised in that：In step (1)
The crushing and beating uses the beater that screen-aperture is 0.6-1.0 millimeters；The rinsing twice of the root of kudzu vine described in step (2) uses
Pure water.
The preparation method of the Chinese medicine composition of wine 8. liver protection according to claim 4 is dispelled, wherein step (2) and (3) China and foreign countries
Circulation is concentrated under reduced pressure temperature as 60-70 DEG C, medicinal extract proportion 1.25, alcohol precipitation 24 hours, takes supernatant concentration, proportion 1.15, precipitation
Thing is standby；Temperature is 95 DEG C in the spray drying tower；The ethanol extraction uses 90% alcohol；The gas heating extraction of opening is
Circulation extraction 3 times, 1.5 hours every time；The filtrate is extracted as merging No. 3 extract solutions.
The preparation method of the Chinese medicine composition of wine 9. liver protection according to claim 4 is dispelled, the step (6) also include following
Step：
A) lophatherum gracile powders of the parts by weight, seabuckthorn fruit powder, kudzu-vine root powder, taurine powder, vitamin c powder are weighed, it is standby；
B) lophatherum gracile powder weighed up, seabuckthorn fruit powder, kudzu-vine root powder, taurine powder, vitamin c powder are added water to cook together it is secondary, first
Secondary plus 10 times of amounts of water, are decocted 2 hours, second plus 8 times of amounts of water, are decocted 1 hour, are merged extract solution, filtration, add ethanol to containing alcohol
Measure as 65%, stir, refrigeration is stood, filtration, and decompression filtrate recycling ethanol is to without alcohol taste and being concentrated into thick paste；
C) above-mentioned thick paste is dried, crushed, obtain the active component of medicine of the present invention.
The preparation method of the Chinese medicine composition of wine 10. the liver protection according to claim 4 or 9 is dispelled, wherein prepared by step (6)
Active component and pharmaceutically acceptable auxiliary material be mixed and made into oral formulations, the oral formulations include but is not limited to pill,
Powder, tablet, capsule, oral liquid.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109043035A (en) * | 2018-08-08 | 2018-12-21 | 佳木斯大学 | A kind of instant hippophae rhamnoide nectar and preparation method thereof for the eyeshield that has effects that relieve the effect of alcohol |
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