CN107183716A - A kind of liver protection is dispelled wine health-care food composition and preparation method thereof - Google Patents

A kind of liver protection is dispelled wine health-care food composition and preparation method thereof Download PDF

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CN107183716A
CN107183716A CN201710447203.9A CN201710447203A CN107183716A CN 107183716 A CN107183716 A CN 107183716A CN 201710447203 A CN201710447203 A CN 201710447203A CN 107183716 A CN107183716 A CN 107183716A
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wine
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梁佳
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Beijing Heled Kang Technology Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4415—Pyridoxine, i.e. Vitamin B6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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Abstract

The invention provides a kind of health-care food composition for wine of being dispelled for liver protection, include the raw material of following parts by weight：Oyster：25 40 parts, sea-buckthorn：40 60 parts, vitamin C：20 30 parts, vitamin B6：0.01 1.5 parts.

Description

A kind of liver protection is dispelled wine health-care food composition and preparation method thereof
Technical field
The present invention relates to food, field of health care products, more particularly to liver protection dispel wine health-care food composition and its preparation side Method.
Background technology
China, which is one, has the country of deep spirits culture, and wine turns into national and carries out the indispensable work of social activities already Tool.Alcohol absorbs from intestines and stomach quickly enters blood, 100% can be absorbed in two hours.Liver is the main of metabolism alcohol Organ, the alcohol dehydrogenase (ADH) that alcohol passes through in liver is catalyzed and generates acetaldehyde, and acetaldehyde takes off through the acetaldehyde in liver mitochondrion Hydrogen enzyme (ALDH) is further oxidized to nontoxic acetic acid, ultimately generates carbon dioxide and energy.
However, the speed of liver oxidative metabolism alcohol is very slow, heavy drinking can cause the concentration of alcohol in blood drastically to rise Height, causes acute alcoholism i.e. drunk.After acute alcoholism, the discomfort of long period can be caused, the long period occur Headache, dizzy, insomnia, it is weak, tremble, have a stomach upset and nausea, or even show as hyponea.Long-term excessive consumption of alcohol, liver Easily accumulate poisoning, cause stem cell alcohol to be denatured, and then develop into fatty liver, hepatic sclerosis even liver cancer.Alcoholic liver Infringement has become one of main reason of chemical damage.
At present, product of sobering up on the market is with natural honey main material mostly.However, honey sober up effect itself has Limit, effect is not good enough, and supply falls short of demand for natural honey in addition, expensive, is not suitable for the demand of industrialization.Other some other solution Wine liver-protecting medicine, main component is based on flower of Radix Puerariae, radix glycyrrhizae, lophatherum gracile, kuh-seng, and curative effect is simultaneously imprecise.
The content of the invention
Dispelled the health-care food composition of wine for liver protection it is an object of the invention to provide a kind of, including following parts by weight Raw material：Oyster：25-40 parts, sea-buckthorn：40-60 parts, vitamin C：20-30 parts, vitamin B6：0.01-1.5 parts.
Preferably, the oyster is 30-35 parts；The sea-buckthorn is 42-58 parts；The vitamin C is 22-28 parts, dimension life Plain B6 is 0.01-1.5 parts.
Preferably, the oyster is 32 parts；The sea-buckthorn is 45 parts；The vitamin C is 22.8 parts；Vitamin B6 is 0.2 part.
It is an object of the invention to provide it is a kind of for liver protection dispel wine health-care food composition preparation method, including under Row step：
(1) fructus hippophae is gone into the removal of impurity, cleaned up, remove its carpopodium flower base of a fruit, add water, crushing and beating is husky by gained The extruding of spine pulp takes juice and filters off residue, and gained juice is dried after filtering and concentrating, and seabuckthorn fruit powder is made；
(2) fresh and alive oyster is taken, broken shell takes full oyster meat, directly or is put into pressure cooker and boils after washing, filter, obtain milky white Color extract solution, then, equivalent pure water is added into residue, about 30min is boiled again, and after being filtered, this filtrate is carried with original Take liquid to mix, then extract solution is evaporated in vacuo, the sticky russet flow fluid that moisture is 67.34% is obtained, by the concentrate Wink-dry is carried out, uniformly light yellow micro mist is obtained；
(3) vitamin C is taken；
(4) vitamin B6 is taken；
(5) above-mentioned four kinds of raw materials are loaded in mixing machine according to the above ratio, fully mixed, the irradiation of cobalt 1 is gone out after pack Bacterium, kept dry.
(6) prepared by finished product：
No. 1 mechanical irrigation preparation shell is selected, filling with preparation bottle placer, 0.3 gram/is aluminum-plastic packaged again using aluminum-plastic packaged Plate, with being fitted into polybag, finally adds outer packing, finished product is made with small desiccant bag.
Preferably, water described in the step (1) is purified water, and the weight of the purified water is 2-5 times of fructus hippophae；Institute The temperature for stating purified water is 50-70 DEG C.
Preferably, water described in the step (1) is purified water, and the weight of the purified water is 3 times of fructus hippophae；It is described The temperature of purified water is 60 DEG C.
Preferably, crushing and beating described in the step (1) uses the beater that screen-aperture is 0.6-1.0 millimeters；Institute It is powdered to state the vitamin C in step (3).
Preferably, filter membrane used is 0.1-0.5 μm of filter membrane in the step (2)；Milipore filter used is that cutoff amount is 3500-6500 milipore filter.
Preferably, filter membrane used is 0.2 μm of filter membrane in the step (2)；Milipore filter used is that cutoff amount is 5000 Milipore filter.
Preferably, crushing and beating described in the step (1) uses the beater that screen-aperture is 0.8 millimeter；The step Suddenly sieving sieve used is 200 mesh in (2).
It should be appreciated that foregoing description substantially and follow-up description in detail are exemplary illustration and explanation, should not As the limitation to claimed content of the invention.
Brief description of the drawings
With reference to the accompanying drawing enclosed, the present invention more purpose, function and advantages will pass through the as follows of embodiment of the present invention Description is illustrated, wherein：
Fig. 1 shows blank control group mouse liver organization chart；
Fig. 2 shows positive controls mouse liver organization chart；
Fig. 3 shows that liver protection is dispelled wine low dose group mouse liver organization chart；
Fig. 4 shows that liver protection is dispelled wine middle dose group mouse liver organization chart；
Fig. 5 shows that liver protection is dispelled wine high dose group mouse liver organization chart.
Embodiment
By reference to one exemplary embodiment, the purpose of the present invention and function and the side for realizing these purposes and function Method will be illustrated.However, the present invention is not limited to one exemplary embodiment as disclosed below；Can by multi-form come It is realized.The essence of specification is only to aid in the detail of the various equivalent modifications Integrated Understanding present invention.
Hereinafter, embodiments of the invention will be described with reference to the drawings.In the accompanying drawings, identical reference represents identical Or similar part, or same or like step.
Dispelled the invention provides a kind of liver protection the health-care food composition of wine, affiliated preparation includes following compositions：Oyster 25-40 parts, 40-60 parts of sea-buckthorn, 0-30 parts of Catergen, vitamin B60.01-1.5 parts (usage amount is micro, and every 100 grams total Vitamin B in medicinal powder6Content be 200 milligrams).Each efficacy of drugs that these drug regimens are is produced into synergy, reached The purpose of relieving alcoholism and protecting liver.
Wherein sea-buckthorn is by sea buckthorn fruit powder, sea buckthorn fruit Quercetin containing flavonoid, Isorhamnetin, kaempferol And its glycosides, and containing vitamin C, vitamin E, carrotene, vitamin B1, vitamin B2, vitamin B6, vitamin B12And leaf Acid；Institute's fatty acids have myristic acid, palmitoleic acid, palmitic acid, stearic acid and oleic acid, linoleic acid, elaidic acid, linolelaidic acid, Arachidonic acid, laurate etc.；Additionally contain a variety of organic acids, saponin(e, sterol, carbohydrate and 15 kinds of trace elements.
Sea-buckthorn has following physiological function：
(1) protection liver and digestive system
20% g kg of sea buckthorn juice 0.84 and 1.68 g kg body weight are to CCL4, paracetamol induced mice damage Increasing for MDA (MDA) has obvious inhibiting effect in liver, and can significantly reduce CCL4The SGPT vigor of poisoning mice, confrontation is flutterred The exhaustion of heat breath pain poisoning mice liver glutathione (GSH).The g kg of Seabuckthorm Seed Oil 0.25 and 0.5 g kg weight gavage, can Significantly reduce CCL4Necrosis region in the liver caused.Electron microscopic observation, CCL4Group rough surfaced endoplasmic reticulum (RER) changes, i.e., small in liver cytoplasm Sheet basophilla material largely disappears, and Seabuckthorn Oil can be such that the material recovers to normal level.Seabuckthorn Oil can be also resisted by CCL4 The dysbolisms such as metabolism, sugar synthesis, glycogen solidification, the protein synthesis of caused liver cell.Seabuckthorn Oil can prevent liver thin Born of the same parents P450 reduction, prevented also from the reduction of total protein in liver and water-solubility protein, and by ethanol and CCl4The cell risen Matter and microsome, the reduction of hepatic protein.In addition, Seabuckthorn Oil intraperitoneal injection has lipotropic effect, and it is chloro- to 3,4- The liver plasma membrane of 1- butylene slow poisoning rats has stabilization.
Neutral lipid composition in Seabuckthorn Oil and seabuckthorn fruit powder has very strong antiulcer action, has to reserpine institute Ulceration Notable antagonism.The healing of gastric ulcer and damage of intestines can be accelerated, stomach lining MDA is reduced and improve neutral amino The concentration of acid.In addition, Seabuckthorn Oil and seabuckthorn fruit powder can make animal saliva and stomach and intestine glandular secretion increase, pepsin content rise. There are stimulation, Rythmic contractions characteristic cycle stretch-out, amplitude increase to gastrointestinal motility function simultaneously.
(2) free radical is removed
Stimulate polymorphonuclear human leukocytes (PMN) raw PMA when containing 1.7 milligrams of total seabuckthorn flavones in every milliliter of sea-buckthorn solution Into active oxygen radical have obvious scavenging action, when containing 0.03-3 milligram total seabuckthorn flavones in every liter of sea-buckthorn solution to yellow fast The active oxygen radical of purine/Huang Piao Ling oxidase systems has the scavenging action of notable dose dependent, but riboflavin is produced The scavenging action of liveliness proof oxygen radical is weaker.Fenton is reacted when containing the milligram hour of total seabuckthorn flavone 3 in every liter of sea-buckthorn solution The HO of generation has obvious scavenging action, and multinuclear people can also be significantly inhibited when containing 1 milligram of total seabuckthorn flavone in every liter of sea-buckthorn solution The luminescent activity that leucocyte is produced.
Mouse is injected intraperitoneally the mg/kg body weight of Seabuckthorn Oil 2.5, Wheat Protein and prevents fatty liver from making With, and lipid peroxidation speed and Vitamin E levels in tissue can be adjusted.Seabuckthorn Oil is similar to vitamin E, and Hyperlipidemic Serum is damaged The vascular smooth muscle cells of wound have protective effect, can substantially reduce elevated MDA in high fat damage smooth muscle cell (LOP) content, and SOD activity can be significantly improved, so as to mitigate damage of the Hyperlipidemic Serum to cell membrane, protect and promote thin The healthy growth of born of the same parents.
(3) it is antifatigue and other
Seabuckthorn fruit powder is rich in vitamin C and various trace elements, has desirable influence to dispelling fatigue and enhancing locomitivity, It also can significantly improve cardiac function.The mg/kg body weight of mouse peritoneal injection total seabuckthorn flavone 2, continuous 6 days, body weight had a net increase of Plus apparently higher than control group.
Heavy dose of sea-buckthorn concentrate can be obviously prolonged the time of yellow Jackets induced mice sleep.Seabuckthorm Seed Oil can show Write the activity for suppressing monoamine oxidase in mouse brain.
Other sea-buckthorn also has enhancing immune, improves cardiovascular system and hemopoietic system function, and anti-tumor radiation With the function such as anti-inflammatory.The seabuckthorn fruit powder that the present invention is used is prepared using vanguard technology, effectively saves sea-buckthorn Contained all functional components in fruit, therefore possess various functions described above.
The physiological function of oyster：
Oyster is rare Hai Zhen, its not only delicious flavour, and nourishing health function also to be spoken approvingly of at all times.Oyster is rich in The mineral matter such as vitamin B complex, inositol, choline and zinc, iron.
Oyster is many to the benefit of human body：
(1) trace element such as mineral matter selenium, zinc that oyster is rich in can promote the immunologic function of body, preventing cold, in addition Zinc can promote the synthesis of protein, thus with enhancing muscle power, recreative effect.
(2) oyster contains more than 20% good protein, and its amino acid composition is perfect, more than cow's milk and human milk.
(3) it is generally composite phospholipid, phosphoinositide, eicosapentenoic acid with physiologically active though oyster is few containing lipid (EPA), docosahexenoic acid (DHA) etc..These compositions prevent artery sclerosis, antithrombotic and anti-aging effects.
(4) oyster is rich in natural taurine.Taurine has eliminating inflammation and expelling toxin, hepatic cholagogic, reducing blood lipid, promotion child brain hair Educate and the effect such as mind-tranquilizing brain-strengthening, its effect is embodied in：
1) hepatic cholagogic, promotes liver function, improves the function of detoxification of liver；
2) lactic acidosis, relaxing smooth muscle, dispelling fatigue are promoted；
3) choleresis, the emulsification of fat, reducing blood lipid are promoted；
4) anti-inflammatory, antipyretic analgesic；
5) alcohol virulence is suppressed.
6) sugared part contained by oyster is that glycogen accounts for 20-40% in glycogen, its extract.Glycogen is the deposit of tissue energy substance Form, is the material guarantee of physical mental activity efficiency and endurance.
Ascorbic physiological function：
(1) redox
In vivo, vitamin C/DHVC redox reaction and sulfydryl (- SH)/cystine linkage (- S-S) system It is associated.Therefore vitamin C can improve in vivo-SH levels.Vitamin C may play the role of to remove free radical in vivo, have A little infringements of the chemical substance to body, are directed to the effect of free radical, such as oxygen, ozone, nitrogen dioxide, alcohol, carbon tetrachloride And damage of the Aclacnomycin A Hydrochloride in anticarcinogen to heart.Vitamin C can resist as internal water miscible antioxidant with fat-soluble Oxidant has synergy, may be played a role on lipid peroxidation is prevented, crystal of human eye in the presence of light, Also O can be produced2Free radical, may be cataract Producing reason.These free radicals are under normal circumstances to be anti-oxidant in vivo Agent such as vitamin C, the sweet peptide of wheat Guang are removed, so substantial amounts of vitamin C can prevent the destruction of this peroxidation.
(2) Vitamin C effect some drugses are metabolized
1. influence of the vitamin C to hepatomicrosome enzyme system；Some fat-soluble medicines under hepatomicrosome enzyme systemic effect, Carry out carboxylated and remove four bases, after polar compound, it is easy to removing toxic substances is discharged from bile and urine.Organochlorine insecticide energy Microsomal enzyme vigor is sent out thoroughly.But this enzyme system reacts sharper to vitamin situation.The degree of hypovitaminosis C is not yet When reaching Body weight loss, the vigor of hydroxylase system has declined in microsome, wherein with the reduction of cytochrome reductase most It is many, about subtract 85%, after replenishing vitamins C, vitamin C amount recovers normal within a short period of time in tissue, but enzyme activity recover compared with Slowly.
2. vitamin C, which also has, goes histamine to act on and prevent the carcinogenesis of benzidine, naphthylamines and nitrosonium salts.
The physiological function of vitamin B6：
It is main to participate in nearly hundred kinds of enzyme reactions in phosphoric acid Vitamin B6 (PLP) form.It is most relevant with amino acid metabolism：Including turning Amino, decarboxylation, side chain cleavage, it is dehydrated and turns sulfurization.These biochemical functions are related to many-side.
1st, protein synthesis and catabolism are participated in, all amino acid metabolisms are participated in, it is relevant such as with the metabolism of ferroheme, with Tryptophan synthesis nicotinic acid is relevant.
2nd, gluconeogenesis, UFA metabolism are participated in.Metabolism with glycogen, sphingomyelin and steroids is relevant.
3rd, some neurotransmitters (serotonin, taurine, dopamine, norepinephrine and γ-aminobutyric acid) are participated in Synthesis.
4th, the metabolism of vitamin B6 and one carbon unit, vitamin B12 and folate, if their dysbolisms can cause huge Normoblast anaemia.
5th, nucleic acid and DNA synthesis are participated in, shortage can damage DNA synthesis, and this process is to maintaining suitable immunologic function It is very important.
6th, the relation of vitamin B6 and vitamin B2 is very close, and Vitamin B6 deficiency is often accompanied by vitamin B2 symptom.
7th, conversion of the homocysteine to methionine is participated in, the effect with reduction chronic disease, the slight high Guang of homotype half Propylhomoserin mass formed by blood stasis is considered as a kind of potentially dangerous factor of vascular diseases, and the intervention of vitamin B6 can reduce the Guang ammonia of blood plasma homotype half Acid content.
The preparation process of the relieving alcoholism and protecting liver preparation of the present invention is as follows：
(1) preparation of seabuckthorn fruit powder：
Choose fresh, good, full maturity, in orange-yellow or salmon pink fructus hippophae, the branch that artificial removal is wherein mingled with The impurity such as leaf soil rock, are cleaned up with clear water, wash away the silt adhered to thereon, worm's ovum etc., and the sea-buckthorn cleaned up is through repairing Whole its carpopodium of removal flower base of a fruit etc., adds the purified water that 2-5 times of weight is 50-70X, equably sends into beater and carries out broken beat Slurry, the screen-aperture of beater should carry out extruding with the juice extractor of spiral 20 and take juice in 0.6-1.0 millimeters, gained sea-buckthorn pulp And filter off residue, after filtering and concentrating, using vacuum and low temperature spray drying process, seabuckthorn fruit powder is made in extruding gained juice.
(2) preparation of oyster：
Fresh and alive oyster is taken, broken shell takes full oyster meat, directly or after washing be put into pressure cooker (pressure is 98kPa), plus etc. Ratio pure water (weight ratio), boils about 30min under 98kPa pressure, recovers after normal pressure, is filtered under diminished pressure with filter paper, obtains milky white Color extract solution.
Then, add equivalent pure water again into residue, about 30min is boiled, after being filtered, by this filtrate and original extraction Liquid is mixed, then extract solution is carried out into vacuum (0.133-0.66kPa, 70-80 DEG C of temperature) distilled, obtain moisture for 67.34% it is viscous Thick russet flow fluid, liquid color compared with before vacuum distillation is light.The concentrate is utilized into common spray dried form (wink Between hot blast temperature be 180 DEG C, outlet temperature be 80 DEG C, speed of dripping be 30mL per minute) carry out wink-dry, obtain uniformly shallow Yellow micro mist is stand-by.
(3) vitamin C.
(4) vitamin B6.
(5) prepared by semi-finished product：
Above-mentioned four kinds of bulk drugs are loaded in mixing machine according to the above ratio, fully mixed, the irradiation sterilization of cobalt 1 after pack (5KGY), kept dry.
(6) prepared by finished product：
No. 1 mechanical irrigation preparation shell is selected, filling with preparation bottle placer, 0.3 gram/is aluminum-plastic packaged again using aluminum-plastic packaged Plate, with being fitted into polybag, finally adds outer packing, finished product is made with small desiccant bag.
The need for according to preparation, it can be assigned in health-care food composition of the present invention containing the medicine commonly used in medicament word field Shape punishment, for example,
Solvent, filler, flavor enhancement, disintegrant, adhesive, lubricant, wetting agent, pigment, bulking agent, diluent, increasing Thick dose etc., any conventional peroral dosage form, such as pill, powder, tablet, capsule are prepared into conventional method of Chinese medicinal Agent, oral liquid etc..The present invention is that capsule (is hereinafter referred to as the dispel preferred dosage form of health-care food composition of wine of liver protection Liver-protecting capsule).
The present invention has effects that obvious relieving alcoholism and protecting liver for the dispel health-care food composition of wine of liver protection, wine of dispelling nourishing Effect.
The present invention dispels for liver protection, and one time a day for day usual amounts for the instructions of taking of health-care food composition of wine, and every time 3 Grain.
The present invention can substantially increase the activity of internal alcohol dehydrogenase for the dispel health-care food composition of wine of liver protection, have There is preferable antialcoholism function.Pharmacological evaluation shows, take for liver protection dispel wine health-care food composition mouse continuously to After wine 15 days, the more normal mouse liver cell of liver cell is without significant change, and the health-care food composition of unused wine of being dispelled for liver protection Mouse continuously to wine after 15 days, then there is obvious alcohol sample lesion in liver cell, illustrates that this is used for liver protection and dispelled the health care food of wine Product composition liver protection effect is obvious.This is used for the dispel health-care food composition of wine of liver protection and entered in Beijing Disease Prevention and Control Centre The experiments such as toxicological assessment, healthcare function evaluation, effective component identification, stability and hygiene inspection are gone, have owned Index reaches examination requirements.Human experimentation also shows that the drug regimen can increase the activity of alcohol dehydrogenase to Alcoholic Hepatic injury has significant protective effect.
Be expanded on further below by way of test example it is of the present invention for liver protection dispel wine health-care food composition it is (following Abbreviation liver-protecting capsule) beneficial effect, these test examples include the present invention and are dispelled for liver protection the health-care food composition of wine Pharmacodynamics test and clinical effect trial.
The method of inspection of functional component, content and functional component is described below
1. functional component
Seabuckthorn fruit powder main composition is general flavone, and oyster main composition is trace element, therefore is detected in product General flavone, ascorbic content, you can reach the purpose of control product quality.
2. content：
Flavones (milligram/100 gram) 310
Vitamin C (gram/100 grams) 20
Vitamin B6 (milligram/100 gram) 10
3. the method for inspection：
3.1 Vitamin C contents are determined：
Meet " Pharmacopoeia of People's Republic of China ", the general provision of version in 2015.
The assay method of 3.2 general flavones
3.2.1 the preparation of rutin standard liquid
0.0210g rutins standard items are accurately weighed in 100mL volumetric flasks plus methanol dissolves and is settled to scale and shakes up again Accurate point takes the 5mL solution to be shaken up in 50mL volumetric flasks with methanol dilution to scale.
3.2.2 the foundation of standard curve
It is accurate draw rutin standard liquid 0.00mL, 1.00mL, 2.00mL, 3.00mL, 4.00mL, 5.00mL, 6.00mL, 7.00mL is in magnetic evaporating dish plus 1g Silons are adsorbed in 85 DEG C of water-baths and fling to methanol, is then transferred to chromatographic column and is washed with methanol Add methanol constant volume to scale to shake up after taking off flavones into 25mL colorimetric cylinders and light absorption value is determined at 360nm wavelength with the micro- of rutin Gram quantity is that abscissa light absorption value is that ordinate does standard curve.
Regression equation Y=5.841667E-04+7.889331E-04*X, coefficient R=0.999246.
3.2.3 assay method
5mL health-care tea beverages are accurately pipetted in magnetic evaporating dish plus 1g Silons are adsorbed in 85 DEG C of water-baths and fling to moisture Then be transferred on chromatographic column with methanol elute flavones into 25mL colorimetric cylinders after shaken up with methanol constant volume to scale this liquid in Light absorption value is determined at 360nm according to the content of the general flavone from the rutin Microgram calculating sample checked on standard curve (with reed Fourth meter).
The measure of 3.3 vitamin B6s：
Vitamin B6 standard：Defer to " Pharmacopoeia of People's Republic of China ", version in 2015, it is adaptable to medicine, food and feed Detection regulation.
Embodiment 1 activates the experiment in vitro of alcohol dehydrogenase：
Alcohol dehydrogenase activity assay method：A Huo He (vaell＆Hoch) method is strangled using watt, and is slightly detected after improvement Alcohol dehydrogenase activity.Sodium pyrophosphate buffer solution 1.5ml is added in pipe is determined, after mixing at 25 DEG C, capping incubates 5mn. Measure pipe after incubation adds alcohol dehydrogenase 0.lml immediately, uses spectrophotometric determination absorbance (A340) after shaking up immediately Value, later reading every 10s once, METHOD FOR CONTINUOUS DETERMINATION 5mn.Zero point is set up with control tube, the reaction of health-care food composition is not added with Group is the blank control group for determining alcohol dehydrogenase activity.
Alcohol dehydrogenase activity computational methods：It is plotted against time with A, negates and answer initial linear segment, calculates A340nm/ 10s value added, is 6.2 according to molar extinction coefficients of the NADH at 340nm, calculates the unit of activity of enzyme.ADH activity with The nanomole number of NADH generations per minute is represented.
(activation) rate of suppression is calculated：
(activation) rate of suppression (%)={ enzymatic activity is without the enzymatic activity dosing measure group of medicine control group one }/enzymatic activity is compareed without medicine Group x100%
Above-mentioned every kind of Chinese medicine experiment is repeated 3 times, and is surveyed experimental data and is represented with x scholar s, is examined using t and carry out statistics Analysis
As a result：
The result of table 1 shows that low dosage liver protection wine capsule, middle dosage liver protection wine capsule, high dose liver protection wine capsule of dispelling of dispelling of dispelling is equal Alcohol dehydrogenase activity is improved, activity ratio is respectively 12.75%, 15.12%, 16.33%, illustrate that liver protection wine capsule of dispelling has The effect of alcohol dehydrogenase activity is activated, and dosage more high ethano dehydrogenase activity ratio is higher.
The liver protection of embodiment 2 is dispelled wine zoopery
Animal packet：Mouse is randomly divided into six groups, every group 8, male and female half and half, wherein 5 groups are made acute alcoholic liver damage Wound model：I.e. positive controls, sobering-up liver-protecting capsule group, are administered low dose group, middle dose group, high dose group；Separately set blank pair According to group.Water 6h is can't help in fasting before modeling and dosage, 5 groups of animal gavages in addition to blank control group, and mouse presses 0.14m/10g Gavage strong, colourless liquor distilled from sorghum；After 20min, by basic, normal, high dosage, (0.15g/kg, 0.3g/kg, 0.45g/kg are respectively administration group mouse Be grown up daily consumption 5,10,15 times) gavage sobering-up liver-protecting capsule；Positive controls gavage same volume physiological saline；Blank control Group is normal to raise；Successive administration 30d.
Experimental implementation：Experiment is filled in first time daily starts timing after drinking, records drunk and number of animals of sobering up (with for the moment In), calculate rate of sobering up and liquor-saturated ratio of waking up；Occur the righting reflex positive be considered as it is drunk (animal foot is lain on the back in platform upwards, 30s voluntarily can not climb over body, and person is the positive, otherwise is feminine gender), righting reflex feminine gender, which is considered as, sobers up.Drunk time and when sobering up Between be designated as tolerance time and recovery time respectively, the situation of change of an each group mouse weight is recorded weekly, mouse is surveyed after 30d The SOD values of LPO values and whole blood；Before experiment, fasting 12 hours extracts eyeball blood sampling, detects the LPO values of serum and the SOD of whole blood Value, puts to death mouse after blood sampling, takes mouse liver to do pathological section.
The LPO of mice serum, the SOD values of whole blood assay method：Lipid peroxidase (LPO), superoxide dismutase Enzyme (SOD) method as defined in its kit is operated.
Hepatic tissue pathology sections observation：Hepatic tissue is taken pictures by doing microscope inspection observation after section.
As a result represent and data analysis：Data analysis is carried out using SPSS11.0 softwares.
As a result it is as follows：
Influence of the wine capsule to mouse weight 1. liver protection is dispelled
1-2 weeks changes of weight result of each experimental mice of table 2
Note：Compared * * with blank control group and represent P<0.01* represents P<0.05
3-4 weeks changes of weight result of each experimental mice of table 3
Note：Compared * * with blank control group and represent P<0.01* represents P<0.05
Table 2, the result of each experimental mice changes of weight of table 3 show, the changes of weight phase with blank control group mouse Than during raising 30 days, the change of other groups of mouse is less than normal, compared with positive controls mouse, takes liver protection and dispels wine capsule Mouse weight tends to be normal.
Influence of the wine capsule to mouse alcohol tolerance time and recovery time 2. liver protection is dispelled
Each model group mouse alcohol tolerance time of table 4 and recovery time result
Note：Compared * * with positive controls and represent P<0.01
From upper table 4, compared with positive controls, take liver protection dispel wine Capsules group mouse alcohol tolerance time it is obvious Lengthen, recovery time substantially shortens, there were significant differences, wherein the effect of middle high dose group is more preferable.
Influence of the wine capsule to mice drunk rate 3. liver protection is dispelled
Drunk result of each model group mouse of table 5 in same time
As a result show, within a certain period of time, the drunk rate of positive controls mouse is 100%, and liver protection is dispelled the liquor-saturated of wine Capsules group Rate is substantially reduced, wherein the middle drunk rate of high dose group mouse is lower, points out a certain amount of liver protection wine capsule of dispelling effectively to drop The drunk rate of low mouse.
Influence of the wine capsule to mouse liver LPO values 4. liver protection is dispelled
Each experimental mice liver homogenate LPO values of table 5
Note：Compared with blank control group, * represents P<0.05
As a result show, compared with blank control group, other each group Mouse Liver LPO values rises compared with positive controls, are given The LPO values of medicine each group are substantially reduced, wherein the reduction of middle high dose group is more notable, illustrate that liver protection wine capsule of dispelling can effectively reduce small Mouse liver LPO values.
Influence of the wine capsule to Mouse whole blood SOD activity 5. liver protection is dispelled
Each experimental mice whole blood SOD values of table 6
Note：Compared with blank control group, * represents P<0.05
Test result indicates that, compared with blank control group, remaining each experimental mice whole blood SOD value is reduced, with the positive Control group is compared, and the SOD values of administration group are significantly increased, and illustrates that liver protection wine capsule of dispelling can effectively improve the SOD of Mouse whole blood Activity.
Each experimental mice liver organization pathological analysis
Fig. 1 is blank control group mouse liver organization chart；
Fig. 2 is positive controls mouse liver organization chart；
Fig. 3 is that liver protection is dispelled wine low dose group mouse liver organization chart；
Fig. 4 is that liver protection is dispelled wine middle dose group mouse liver organization chart；
Fig. 5 is that liver protection is dispelled wine high dose group mouse liver organization chart.
Referring to Fig. 1-Fig. 5, result above shows, after 30d is raised, and blank control group mouse, lobuli hepatis structure is normal, liver Rope is arranged radially centered on central vein, and cell is in polyhedron, and monokaryon, accidental double-core, core is big and round, in cell Centre；Positive controls mouse, liver cell obvious tumefaction, necrosis, kytoplasm is loose, and diffusivity balloon sample becomes, and kytoplasm apparent number is not One, the fat drips that differ in size vacuole：Sobering-up liver-protecting capsule group mouse, lobuli hepatis structure is normal, and liver rope is using central vein in The heart is arranged radially；High dose group mouse, lobuli hepatis structure is normal, and liver rope is arranged radially centered on central vein, Cell is in polyhedron, and monokaryon, accidental double-core, core is big and round, positioned at cell center；Middle dose group and low dose group mouse, liver are thin Born of the same parents' structure is normal, has slight haziness, swelling, fat to become, liver protection indicated above wine capsule of dispelling can be effectively protected Mouse Liver Tissue.
2. dispelled the health-care food composition and its system of wine for liver protection the present invention is expanded on further by the following examples Preparation Method：
Embodiment 1
The weight of liver-protecting capsule material component of the present invention is：
45 kilograms of sea-buckthorn
32 kilograms of oyster
22.8 kilograms of vitamin C pulvis
0.2 kilogram of vitamin B6
The preparation process of liver-protecting capsule of the present invention is as follows：
(1) preparation of sea-buckthorn：
Choose fresh, good, full maturity, in orange-yellow or salmon pink fructus hippophae, the branch that artificial removal is wherein mingled with The impurity such as leaf soil rock, are cleaned up with clear water, wash away the silt adhered to thereon, worm's ovum etc., and the sea-buckthorn cleaned up is through repairing Whole its carpopodium of removal flower base of a fruit etc., adds the purified water that 3 times of weight are 60 DEG C, equably sends into beater and carry out crushing and beating, beat The screen-aperture of frame machine should be in 0.8 millimeter, and gained sea-buckthorn pulp carries out extruding with spiral juice extractor and takes juice and filter residue Go, after filtering and concentrating, using vacuum and low temperature thousand dry methods of spraying, seabuckthorn fruit powder is made in extruding gained juice.
(2) preparation of oyster：
Fresh and alive oyster is taken, broken shell takes full oyster meat, directly or after washing be put into pressure cooker (pressure is 98kPa), plus etc. Ratio pure water (weight ratio), boils about 30min under 98kPa pressure, recovers after normal pressure, is filtered under diminished pressure with filter paper, obtains milky white Color extract solution.
Then, add equivalent pure water again into residue, about 30min is boiled, after being filtered, by this filtrate and original extraction Liquid is mixed, then extract solution is carried out into vacuum (0.133-0.66kPa, 70-80 DEG C of temperature) distilled, obtain moisture for 67.34% it is viscous Thick russet flow fluid, liquid color compared with before vacuum distillation is light.The concentrate is utilized into common spray dried form (wink Between hot blast temperature be 180 DEG C, outlet temperature be 80 DEG C, speed of dripping be 30mL per minute) carry out wink-dry, obtain uniformly shallow Yellow micro mist is stand-by.
(3) vitamin C pulvis：Commercially available pharmaceutical grade vitamin c powder；
(4) vitamin B6 pulvis：Commercially available pharmaceutical grade vitamin B6 powder
(5) prepared by semi-finished product：
Take 45 kilograms of seabuckthorn fruit powder, 32 kilograms of oyster, 22.8 kilograms of vitamin C, 0.2 kilogram of loading mixing machine of vitamin B6 It is interior, fully mix, the irradiation sterilization of cobalt 1 (5KGY) after pack, thousand dry preservations.
(6) prepared by finished product：
No. 1 mechanical irrigation capsule shell of selection, 0.3 gram/filling with capsule filling machine, then using aluminum-plastic packaged, it is aluminum-plastic packaged Plate, with being fitted into polybag, finally adds outer packing, finished product is made with small desiccant bag.
With reference to the explanation of the invention disclosed here and practice, other embodiment of the invention is for those skilled in the art It all will be readily apparent and understand.Illustrate and embodiment is to be considered only as exemplary, of the invention true scope and purport is equal It is defined in the claims.

Claims (10)

1. a kind of health-care food composition for wine of being dispelled for liver protection, includes the raw material of following parts by weight：Oyster：25-40 parts, sand Spine：40-60 parts, vitamin C：20-30 parts, vitamin B6：0.01-1.5 parts.
2. the health-care food composition of wine according to claim 1 of being dispelled for liver protection, it is characterised in that：The oyster is 30-35 parts；The sea-buckthorn is 42-58 parts；The vitamin C is 22-28 parts, vitamin B6 is 0.01-1.5 parts.
3. the health-care food composition of wine according to claim 1 of being dispelled for liver protection, it is characterised in that：The oyster is 32 Part；The sea-buckthorn is 45 parts；The vitamin C is 22.8 parts；Vitamin B6 is 0.2 part.
The preparation method of the health-care food composition of wine 4. a kind of liver protection is dispelled, comprises the following steps：
(1) fructus hippophae is gone into the removal of impurity, cleaned up, removed its carpopodium flower base of a fruit, add water, crushing and beating, by gained fructus hippophae Slurry extruding takes juice and filters off residue, and gained juice is dried after filtering and concentrating, and seabuckthorn fruit powder is made；
(2) fresh and alive oyster is taken, broken shell takes full oyster meat, directly or is put into pressure cooker and boils after washing, filter, obtain milky and carry Liquid is taken, then, adds equivalent pure water again into residue, about 30min is boiled, after being filtered, by this filtrate and original extract solution Mixing, then extract solution is evaporated in vacuo, the sticky russet flow fluid that moisture is 67.34% is obtained, the concentrate is carried out Spray drying, obtains uniformly light yellow micro mist；
(3) vitamin C is taken；
(4) vitamin B6 is taken；
(5) above-mentioned four kinds of raw materials are loaded in mixing machine according to the above ratio, fully mixed, the irradiation sterilization of cobalt 1 after pack, done It is dry to preserve.
(6) prepared by finished product：
Select No. 1 mechanical irrigation preparation shell, it is filling with preparation bottle placer, 0.3 gram/again using aluminum-plastic packaged, plastic-aluminum packing plate with Small desiccant bag finally adds outer packing, finished product is made with being fitted into polybag.
The preparation method of the health-care food composition of wine 5. liver protection according to claim 4 is dispelled, it is characterised in that：The step Suddenly water described in (1) is purified water, and the weight of the purified water is 2-5 times of fructus hippophae；The temperature of the purified water is 50-70 ℃。
The preparation method of the health-care food composition of wine 6. liver protection according to claim 4 is dispelled, it is characterised in that：The step Suddenly water described in (1) is purified water, and the weight of the purified water is 3 times of fructus hippophae；The temperature of the purified water is 60 DEG C.
The preparation method of the health-care food composition of wine 7. the liver protection according to any one of claim 4-6 is dispelled, its feature It is：Crushing and beating described in the step (1) uses the beater that screen-aperture is 0.6-1.0 millimeters；In the step (3) Vitamin C to be powdered.
The preparation method of the health-care food composition of wine 8. the liver protection according to any one of claim 4-6 is dispelled, its feature It is：Filter membrane used is 0.1-0.5 μm of filter membrane in the step (2)；Milipore filter used is that cutoff amount is the super of 3500-6500 Filter membrane.
The preparation method of the health-care food composition of wine 9. liver protection according to claim 8 is dispelled, it is characterised in that：The step Suddenly filter membrane used is 0.2 μm of filter membrane in (2)；Milipore filter used is the milipore filter that cutoff amount is 5000.
The preparation method of the health-care food composition of wine 10. liver protection according to claim 7 is dispelled, it is characterised in that：It is described Crushing and beating described in step (1) uses the beater that screen-aperture is 0.8 millimeter；Sieving sieve used in the step (2) Son is 200 mesh.
CN201710447203.9A 2017-06-14 2017-06-14 A kind of liver protection is dispelled wine health-care food composition and preparation method thereof Withdrawn CN107183716A (en)

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CN109043035A (en) * 2018-08-08 2018-12-21 佳木斯大学 A kind of instant hippophae rhamnoide nectar and preparation method thereof for the eyeshield that has effects that relieve the effect of alcohol
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