CN107616982A - A kind of nitrite antidote and preparation method thereof, application - Google Patents
A kind of nitrite antidote and preparation method thereof, application Download PDFInfo
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- CN107616982A CN107616982A CN201710855549.2A CN201710855549A CN107616982A CN 107616982 A CN107616982 A CN 107616982A CN 201710855549 A CN201710855549 A CN 201710855549A CN 107616982 A CN107616982 A CN 107616982A
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Abstract
The present invention relates to a kind of nitrite antidote, and in particular to a kind of nitrite antidote and preparation method thereof, application.The preparation method of the nitrite antidote of the present invention, comprises the following steps：1) molybdenum salt, mantoquita, water are mixed, reaction, obtains alkali formula copper molybdate；2) alkali formula copper molybdate is soaked in zinc solution, soaks 1.5~2.5h, produce.The preparation method of the nitrite antidote of the present invention, it is simple and easy, it is adapted to batch production, and the nitrite antidote obtained using preparation method of the present invention has good detoxifying effect to nitrite.
Description
Technical field
The present invention relates to a kind of nitrite antidote, and in particular to a kind of nitrite antidote and preparation method thereof,
Using.
Background technology
Nitrite is in the chemical substance being widely present in natural environment, particularly food, such as grain, vegetables, meat
Class and fish all contain a certain amount of nitrite.
Numerous studies show, because farmland, vegetable garden largely use nitrogenous fertilizer, cause the nitrate nitrogen content in soil generally inclined
Height, in the presence of soil nitrification bacterium, the nitrogen of various forms is converted to NO in soil3-And be that grain, vegetables etc. absorb,
Accumulated in plant, excessive accumulation is not only damaged in itself to plant or quality decline, and is by food chain
Thing and human body are absorbed, and nitrite is changed into animal body or body and then is dived to the health care belt of animal body, human body
Harm.
Nitrite is mainly absorbed into blood by alimentary canal, makes the Fe in hemoglobin in blood2+It is oxidized to Fe3 +, so that hemoglobin loses oxygen carrying capacity, make body tissue anoxic, so that histocyte compensatory response, makes animal body
Basic metabolism improve, reduce the tolerance of animal body.
How alleviating, reducing harm of the nitrite to human body, animal body is a urgent problem to be solved.
The content of the invention
It is an object of the invention to provide a kind of preparation method of nitrite antidote, obtained nitrite antidote
There is good mitigation to nitrite poisoning.
Second object of the present invention is to provide a kind of nitrite antidote, to solve prior art nitrite
Improve animal body basic metabolism caused by poisoning, reduce the technical problem of the tolerance of animal body.
Third object of the present invention is to provide a kind of application of nitrite antidote in terms of feed addictive.
To achieve the above object, the technical scheme is that：
A kind of preparation method of nitrite antidote, comprises the following steps：
1) molybdenum salt, mantoquita, water are mixed, reaction, obtains alkali formula copper molybdate；
2) alkali formula copper molybdate is soaked in zinc solution, soaks 1.5~2.5h, produce.
The molybdenum salt is sodium molybdate.Molybdenum mainly realizes its biological function by influenceing the activity of molybdenum enzyme, and it joins first
Confactor with forming some small molecules, then participates in the synthesis of molybdenum enzyme in the form of confactor.Molybdenum enzyme hypoxanthine aoxidizes
Enzyme can adjust the metabolism of internal iron, promote the release of iron in liver ferritin, promote iron to enter blood plasma, be catalyzed Fe2+It is converted into Fe3 +And be combined into transferrin with B2 globulin and utilized for body, so that red blood cell in blood, hemoglobin content increase, alleviate
Haemoglobin trait caused by nitrite poisoning.Molybdenum participates in the formation of nitrate reductase, is lacked so as to alleviate caused by nitrite
Oxygen symptom, further mitigate histiocytic compensatory, reduce body basic metabolism, improve the tolerance of animal body.
The mantoquita is copper sulphate.
The zinc salt is zinc sulfate.
The mass ratio of the molybdenum salt and mantoquita is 0.03~1.4:0.04~0.36.
Molybdenum salt, mantoquita, water are mixed into step 1) and mix molybdenum saline solution with copper salt solution.
The mass fraction of above-mentioned molybdenum saline solution is 1.5~14%.The mass fraction of the molybdenum saline solution is preferably 2-
9%.
The mass fraction of above-mentioned copper salt solution is 2~18%.The mass fraction of the copper salt solution is preferably 3-
12%.
The mass ratio of the molybdenum saline solution and copper salt solution is 10~2:2.
Molybdenum and copper are the antagonism relationship in animal body, and molybdenum salt and the alkali formula molybdic acid copper compound of mantoquita generation can be alleviated in molybdenum
Due to some side effects caused by supplement molybdenum, (such as copper albuminoid is reduced, and copper lacks for prevention while body natrium nitrosum is poisoned
Disease etc.), almost while target spot is reached in vivo because both form after compound, the hair of side effect can be reduced to greatest extent
It is raw.
Zinc concentration is 300-960 mg/litres in the zinc solution.
Reaction in step 1) is 60 DEG C of 30~45min of reaction.
Alkali formula copper molybdate obtained by step 1) has certain adsorption capacity, and surface is attached after being soaked for a long time in zinc solution
A large amount of zinc salt molecules, on the one hand alleviates and mends the side effect that molybdenum ribbon is come, are on the other hand preventing and alleviating natrium nitrosum poisoning
Zinc needed for body is supplemented simultaneously, promotes growth.
Scrubbed, dry, milled processed before the alkali formula copper molybdate is soaked in zinc solution, obtain alkali formula molybdic acid copper powder.
The drying is 60 DEG C of drying.
The mass ratio of the alkali formula molybdic acid copper powder and zinc solution is 1:1~20.
In step 2) after 1.5~2.5h of immersion, centrifugal dehydration, 60 DEG C of drying nitrite antidotes.
A kind of nitrite antidote, is made using above-mentioned preparation method.
Above-mentioned nitrite antidote, it is pill, tablet or capsule.
Above-mentioned nitrite antidote, the excipient of appropriate amount can be added, pill, tablet or capsule is made.
Above-mentioned excipient is the one or more in starch, sucrose, lactose, pectin, stearic acid.
Application of the above-mentioned nitrite antidote in terms of feed addictive.
The nitrite antidote of the present invention, molybdenum, zinc, the dosage of copper are within safe range, and animal is in edible nitrous
When the exceeded feed of sour sodium content, forage grass or water source, using the antidote, it can not only reach prevention and alleviate in natrium nitrosum
The purpose of poison, effectively antagonism mends the toxic side effect that molybdenum ribbon is come to and can, improves the overall economic efficiency of cultivation.The nitrous of the present invention
The quantity delivered of each element is all controlled without property of medicine acting section in hydrochlorate antidote, all on the demand of animal, and far away from peace
Under full dose, there is good mitigation to nitrite poisoning, reduce body basic metabolism, improve the tolerance of animal body
Property.
The preparation method of the nitrite antidote of the present invention is simple, is adapted to batch production.
The nitrite antidote of the present invention is as feed addictive, the effect with good alleviation nitrite poisoning
Fruit.
Embodiment
Embodiment 1
The preparation method of the present embodiment nitrite antidote, comprises the following steps：
1) copper-bath for being 2% for sodium molybdate solution and mass fraction of mass fraction 1.5% is mixed, stirring is equal
It is even to react 30min after 60 DEG C, obtain alkali formula copper molybdate；Wherein, the mass ratio of sodium molybdate solution and copper-bath is 10:2；
2) after alkali formula copper molybdate obtained by step 1) is fully washed, 60 DEG C of drying, it is then ground to alkali formula molybdic acid copper powder；
3) take alkali formula molybdic acid copper powder obtained by step 2) to be soaked in the solution of zinc sulfate that zinc concentration is 300mg/L, vibrate 2h,
Then low-speed centrifugal is dehydrated, and 60 DEG C of drying, is ground and is produced；The mass ratio of alkali formula molybdic acid copper powder and solution of zinc sulfate is 1:1.
The nitrite antidote of the present embodiment, excipient starch, lactose can be further added, pill is made.
The nitrite antidote of the present embodiment can be used as feed addictive.
Embodiment 2
The preparation method of the present embodiment nitrite antidote, comprises the following steps：
1) copper-bath for being 3% for sodium molybdate solution and mass fraction of mass fraction 2% is mixed, stirring is equal
It is even, 60 DEG C of reaction 45min, obtain alkali formula copper molybdate；Wherein, the mass ratio of sodium molybdate solution and copper-bath is 5:2；
2) after alkali formula copper molybdate obtained by step 1) is fully washed, 60 DEG C of drying, it is then ground to alkali formula molybdic acid copper powder；
3) take alkali formula molybdic acid copper powder obtained by step 2) to be soaked in the solution of zinc sulfate that zinc concentration is 450mg/L, vibrate 2h,
Then low-speed centrifugal is dehydrated, and 60 DEG C of drying, is ground and is produced；The mass ratio of alkali formula molybdic acid copper powder and solution of zinc sulfate is 1:20.
The nitrite antidote of the present embodiment, excipient sucrose, stearic acid can be further added, tablet is made.This reality
The nitrite antidote for applying example can be used as feed addictive.
Embodiment 3
The preparation method of the present embodiment nitrite antidote, comprises the following steps：
1) copper-bath for being 12% for sodium molybdate solution and mass fraction of mass fraction 9% is mixed, stirring is equal
It is even, 60 DEG C of reaction 35min, obtain alkali formula copper molybdate；Wherein, the mass ratio of sodium molybdate solution and copper-bath is 2:2；
2) after alkali formula copper molybdate obtained by step 1) is fully washed, 60 DEG C of drying, it is then ground to alkali formula molybdic acid copper powder；
3) alkali formula molybdic acid copper powder obtained by step 2) is taken to be soaked in the solution of zinc sulfate that zinc concentration is 960mg/L, vibration
2.5h, then low-speed centrifugal dehydration, 60 DEG C of drying, grind and produce；The mass ratio of alkali formula molybdic acid copper powder and solution of zinc sulfate is 1:
15。
The nitrite antidote of the present embodiment, excipient pectin can be further added, capsule is made.
The nitrite antidote of the present embodiment can be used as feed addictive.
Embodiment 4
The preparation method of the nitrite antidote of the present embodiment, comprises the following steps：
1) copper-bath for being 18% for sodium molybdate solution and mass fraction of mass fraction 14% is mixed, stirring is equal
It is even, 60 DEG C of reaction 40min, obtain alkali formula copper molybdate；Wherein, the mass ratio of sodium molybdate solution and copper-bath is 8:2；
2) after alkali formula copper molybdate obtained by step 1) is fully washed, 60 DEG C of drying, it is then ground to alkali formula molybdic acid copper powder；
3) alkali formula molybdic acid copper powder obtained by step 2) is taken to be soaked in the solution of zinc sulfate that zinc concentration is 500mg/L, vibration
1.5h, then low-speed centrifugal dehydration, 60 DEG C of drying, grind and produce；The mass ratio of alkali formula molybdic acid copper powder and solution of zinc sulfate is 1:
10；
The nitrite antidote of the present embodiment can be used as feed addictive.
Experimental example
This experimental example carries out measure of merit to the gained nitrite antidote of embodiment 1.The purebred little Bai of experiment selection health
Mouse 72, body weight 19g or so, after adapting to 5d, 6 groups are randomly divided into, and added respectively in I, II, III, IV, V group of drinking-water
NaNO2(100mg/kg)；NaNO2(100mg/kg), antidote (1000mg/L)；NaNO2(200mg/kg), antidote
(1000mg/L)；NaNO2(200mg/kg), antidote (2000mg/L)；Antidote (1000mg/L)；VIth group is experimental design
Blank control group, do not add any material in drinking-water.
Experimental period is 35 days, observes clinical manifestation, routine weighing, detection hematological indices, periphery blood T lymphocyte sun
Property rate and spleen, the Pathologic changes of Gan Zang ﹑ renal tissues.
Result of the test shows：IIIth, IV group of small white mouse is poisoned to death phenomenon, weight gain difference not significantly (P between each group>
0.05)；II group shows with V group, I group with III group, I group with VI group, III group with VI group of red blood cell RBC ﹑ Hb H b differences
Write (P<0.05)；I group with V group, I group with VI group, II group with V group, II group with VI group of leucocyte WBC number significant differences (P<
0.05)；I group and II group, II group and III group, III group and VI group of T lymphocyte positive rate significant differences (P<0.05), I group and V
Group, III group and V group of significant difference (P<0.05), V group decreases compared with VI group of T lymphocyte positive rate, and under being in group
Drop trend, II and V group, II and VI group, IV group with VI group of T lymphocytes positive rate without significant change (P>0.05)；II group of ratio I
Group, IV group of III group of ratio, II group of than V group mouse tolerance have the trend of enhancing.It can thus be appreciated that：The nitrite of the present invention
Antidote can alleviate methemoglobinemia caused by nitrite, mitigate poisoning symptom.
Claims (10)
1. a kind of preparation method of nitrite antidote, it is characterised in that comprise the following steps：
1) molybdenum salt, mantoquita, water are mixed, reaction, obtains alkali formula copper molybdate；
2) alkali formula copper molybdate is soaked in zinc solution, immersion 1.5~2.5, produced.
2. the preparation method of nitrite antidote according to claim 1, it is characterised in that the molybdenum salt is molybdic acid
Sodium.
3. the preparation method of nitrite antidote according to claim 1, it is characterised in that the molybdenum salt and mantoquita
Mass ratio is 0.03~1.4:0.04~0.36.
4. the preparation method of the nitrite antidote according to claim any one of 1-3, it is characterised in that in step 1)
Molybdenum salt, mantoquita, water are mixed into the mixing of molybdenum saline solution and copper salt solution.
5. the preparation method of nitrite antidote according to claim 1, it is characterised in that the reaction in step 1) is
60 DEG C of 30~45min of reaction.
6. the preparation method of nitrite antidote according to claim 1, it is characterised in that the alkali formula copper molybdate leaching
Scrubbed, the dry, milled processed before zinc solution is steeped, obtains alkali formula molybdic acid copper powder.
7. the preparation method of nitrite antidote according to claim 6, it is characterised in that the alkali formula molybdic acid copper powder
Mass ratio with zinc solution is 1:1~20.
8. a kind of nitrite antidote, it is characterised in that be made using preparation method as claimed in claim 1.
9. nitrite antidote according to claim 8, it is characterised in that be pill, tablet or capsule.
A kind of 10. application of the nitrite antidote in terms of feed addictive as claimed in claim 8.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103466803A (en) * | 2013-09-02 | 2013-12-25 | 鄂州市广丰生态农业开发有限责任公司 | Ameliorant for water quality of aquatic products and preparation method thereof |
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2017
- 2017-09-20 CN CN201710855549.2A patent/CN107616982A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103466803A (en) * | 2013-09-02 | 2013-12-25 | 鄂州市广丰生态农业开发有限责任公司 | Ameliorant for water quality of aquatic products and preparation method thereof |
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| JIANG WEN-JUN ET AL: "Synthesis of Nano-sized Tabular Lindgrenite (Cu3(MOO4)2(OH2) by Aqueous", 《无机材料学报》 * |
| 何银洲: "《最新维生素 矿物质全集》", 31 July 2007 * |
| 刘继业，等: "《饲料安全工作手册》", 30 April 2001 * |
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Application publication date: 20180123 |