CN105211856A - A kind of fatigue resistant health food and preparation method thereof - Google Patents

A kind of fatigue resistant health food and preparation method thereof Download PDF

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Publication number
CN105211856A
CN105211856A CN201510641879.2A CN201510641879A CN105211856A CN 105211856 A CN105211856 A CN 105211856A CN 201510641879 A CN201510641879 A CN 201510641879A CN 105211856 A CN105211856 A CN 105211856A
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health food
parts
raw material
fatigue resistant
lubricant
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曹珍艳
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Beijing Competitor Sports Technology Co Ltd
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Beijing Competitor Sports Technology Co Ltd
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs

Abstract

The invention discloses a kind of fatigue resistant health food; this health food comprises the raw material of following weight portion: gadol extract 15-90 part; taurine 1-40 part; pueraria root powder 10-40 part, glutamine 0-7 part, arginine 0-6 part; zinc gluconate 0-4 part; microcrystalline cellulose 0-5 part, auxiliary material 0-20 part, lubricant 0-2 part.The preparation method of this fatigue resistant health food comprises step: take raw material according to weight portion, bulk or coarse raw material are pulverized, all raw materials are crossed 80-100 mesh sieve, mix with equal increments hybrid technology according to formula, add the ethanol of the volumetric concentration 70-95% accounting for gross weight 5-15%, be uniformly mixed granulation 15-30 minute, cross 10-30 mesh sieve, 60-100 DEG C of oven dry, batch mixing is obtained after the whole grain of 10-30 mesh sieve, add the lubricant of formula ratio, mixing and stirring, be pressed into sheet.The each component Synergistic of health food of the present invention, has significant antifatigue effect.

Description

A kind of fatigue resistant health food and preparation method thereof
Technical field
The present invention relates to technical field of health care food, more specifically relate to a kind of fatigue resistant health food and preparation method thereof.
Background technology
Modern society's rhythm is fast, dog-eat-dog, people's operating pressure strengthens, tired crowd significantly rises, psychological pressure causes greatly mental fatigue serious, brain dominates the function of each organ of whole body, long-term mental fatigue will cause viscera function not enough, function declines, body is because producing anaerobic metabolism for hypoxgia, there is too much refuse, as lactic acid, oxygen radical etc., cause nervous system disorder, endocrine disturbance, immunologic function declines, bring out various disease or make original disease aggravation, even cause gloomy, the psychological changes such as agitation, Here it is " falling sick from overwork ", also can cause time serious " overworking broken dead ", human body anoxia metabolism simultaneously produces too much oxygen radical etc. and more can cause damage to cardio-cerebrovascular, cause heart change, atherosclerotic, cerebral embolism etc., and the locomitivity of people can be affected, fatigue is the killer affecting health.Therefore the functional food needing good anti-fatigue effect is intervened.The anti-fatigue effect health food studying effect distinguished has certain value to tired crowd.
Summary of the invention
(1) technical problem that will solve
The technical problem to be solved in the present invention is exactly how to improve the anti-fatigue effect of anti-fatigue effect health food, and provides a kind of fatigue resistant health food and preparation method thereof.
(2) technical scheme
In order to solve the problems of the technologies described above; the invention provides a kind of fatigue resistant health food; this health food comprises the raw material (raw materials used be all commercially available) of following weight portion: gadol extract (buying from Jiahe, Shaanxi) 15-90 part, taurine 1-40 part, pueraria root powder (buying from Dalian Mai Po) 10-40 part; glutamine 0-7 part; arginine 0-6 part, zinc gluconate 0-4 part, microcrystalline cellulose 0-5 part; auxiliary material 0-20 part, lubricant 0-2 part.
Preferably, described health food comprises the raw material of following weight portion: gadol extract 25-80 part, taurine 3-30 part, pueraria root powder 15-35 part; glutamine 1-5 part, arginine 1-5 part, zinc gluconate 1-3 part; microcrystalline cellulose 1-4 part, auxiliary material 4-19 part, lubricant 1-2 part.
Preferably, described health food comprises the raw material of following weight portion: gadol extract 30-70 part, taurine 7-26 part, pueraria root powder 20-30 part; glutamine 1-4 part, arginine 1-4 part, zinc gluconate 1-2.5 part; microcrystalline cellulose 1-3 part, auxiliary material 6-15 part, lubricant 1-1.8 part.
Preferably, described health food comprises the raw material of following weight portion: gadol extract 40-55 part, taurine 16-23 part, pueraria root powder 22-28 part; glutamine 1-3 part, arginine 1-3 part, zinc gluconate 1-2.2 part; microcrystalline cellulose 1-2 part, auxiliary material 7-11 part, lubricant 1-1.5 part.
Preferably, described health food comprises the raw material of following weight portion: gadol extract 45-48 part, taurine 18-20 part, pueraria root powder 22-25 part; glutamine 1-2 part, arginase 12-2.5 parts, zinc gluconate 1-2 part; microcrystalline cellulose 1-1.5 part, auxiliary material 7-8 part, lubricant 1-1.2 part.
Preferably, described health food comprises the raw material of following weight portion: gadol extract 48 parts, taurine 18 parts, pueraria root powder 22 parts, glutamine 2 parts, arginase 12 part, zinc gluconate 2 parts, microcrystalline cellulose 1 part, auxiliary material 8 parts, lubricant 1 part.
Preferably, described auxiliary material is cornstarch.
Preferably, described lubricant is dolomol.
Preferably, Determination of Salidroside >=3% of described gadol extract.
Present invention also offers the preparation method of fatigue resistant health food, the method comprising the steps of: take raw material according to weight portion, bulk or coarse raw material are pulverized, all raw materials are crossed 80-100 mesh sieve, mix with equal increments hybrid technology according to formula, cross 20-60 mesh sieve, put into mixer to stir, mixing time 15-30 minute, cross 20-60 mesh sieve, put into mixer Homogeneous phase mixing again, mixing time 15-30 minute, after 20-40 mesh sieve, (cycle-index is more, effect is better, arrive the fineness limit of mesh sieve adjustment), add the ethanol of the volumetric concentration 70-95% accounting for gross weight 5-15%, be uniformly mixed granulation 15-30 minute, cross 10-40 mesh sieve, 60-100 DEG C of oven dry, after 10-40 mesh sieve, whole grain obtains batch mixing, add the lubricant of formula ratio, mixing and stirring, be pressed into sheet.
In production medicine or food, because each component ratio differs greatly in formula, not easily mix, therefore adopt " equal increments method " effect better.Its concrete operation method is: get the component that the amount of component in a small amount and equivalent is large, be placed in mixing machinery simultaneously and mix, the larger component of the amount adding same mixture equivalent mixes, and times amount like this increases till adding the large component of whole amount.
Rhodiola root has ginseng and the similar effect of wilsonii, but without ginseng strong excitation, easily to get angry the disadvantage of easy constipating effect of phenomenon and wilsonii.Animal experiment proves that rhodiola root has following effect:
(1) protection cardiac muscle, strengthens myocardial contractive power, function of resisting myocardial ischemia;
(2) nervous system excitability can be improved, anti-central nerve fatigue, reduce serotonin in brain caused by hyperkinesia too high, relatively raise the concentration of dopamine;
(3) internal system is regulated, the incretory such as excitement and adjustment adrenal gland, thymus gland and ovary, the hypoglycemia that the hyperglycaemia stoping adrenaline to cause and insulin cause;
(4) enhancing substance metabolism, promotes that the decomposition of Mouse Liver glycogen and muscle glycogen utilizes, improves ATP, DNA and protein level in skeletal muscle;
(5) hemoglobin and red blood cell number in blood can be made to increase, reduce blood urea nitrogen, reduce the content of lactic acid in blood, reduce oxygen consumption rate, extend run duration, resisting kinetic fatigue.Clinical data shows: the fault rate that rhodiola rosea formulated product works under improving muscle power, intelligence, the ability to work of experimenter, particularly tired situation.
Agate coffee, also known as Peru's ginseng, for being similar to the block root class plant of radish, belonging to Cruciferae, originating in the mountain area, Andean of more than height above sea level 4000m in the middle part of Peru.Modern medicine study proves, agate coffee has and strengthens fecundity, improvement function, antifatigue, the pharmacological action such as anti-oxidant.Supplement agate coffee has-Ding effect to the body injury that long-time exhausted movemeat causes, body weight can be suppressed to a certain extent relatively to increase downward trend, improve rat anti-fatigue ability, and then prolong rats run duration, and in dose dependent, but do not have not present with the increase of dosage to increase progressively state significantly to the effect of body injury.Its mechanism may be:
(1) abundant energy supply can be provided for rat containing abundant nutriment [rich in protein (8.87%) and total reducing sugar (19.85%)] in agate coffee.
(2) a large amount of branched-chain amino acids (20.14% total amino acid) and a certain amount of taurine is contained in agate coffee.Tired and the nervous centralis fatigue of branched-chain amino acid and taurine resisted motion all has certain help.
(3) although in agate coffee fat content not high, the ratio of unrighted acid is high especially, and the ratio that the polyunsaturated fatty acid (linoleic acid and alpha-linolenic acid) with various health-care accounts for aliphatic acid reaches 60.3%.There are some researches show, oral unrighted acid can change the distribution of the rear endogenous androgens of motion, androgenic activity after improving tiring exercises, to improving locomitivity and promoting that tired elimination has physiological significance.
(4) in agate coffee, the multiple chemical composition mineral matter with antifatigue effect such as calcium, magnesium, zinc enriches.
(5) reduction of glycogen content is the key factor that body resisting fatigue ability declines.Agate coffee can significantly improve the rear rat muscle glycogen of motion and hepatic glycogen content, for body provides good energy reserve at the volley, thus plays certain antifatigue effect.
Taurine can significantly improve the concentration of branched-chain amino acid in blood (BCAA); aromatic amino acid (AAA) is declined with the ratio of BCAA; AAA is inhibit to operate into brain; serotonin in brain is suppressed to increase; keep central excitation; improve transmitter in central nervous system unbalance, delayed motion fatigue produces.Animal experiment proves that taurine can increase substantially the locomitivity of rat; reduce WBV; reduce packed cell volume and MDA; raise GSH-Px; increase the oxidation resistance of body; increase the clearance rate of free radical; improve anaemia: taurine can also reduce blood sugar; promote that myocyte is to glucose and amino acid whose picked-up and utilization; accelerate glycolysis, increase gluconeogenesis, separately can increase the amino acid whose concentration of energy supply in skeletal muscle; regulate lipid metaboli, these all can alleviate the exhaustion of energy substance in motion process.Taurine also can maintain cardiac muscle cell's intracellular free calcium level, improves cardiac muscle cell's hypoxia-bearing capability, increases myocardial contractive power.Human trial show sportsman daily 400mg taurine carry out 70%V0 2max cycle ergometer moves, and can significantly improve locomitivity compared with control group, promotes the recovery of postexercise heart rate, reduces the rising of the rear red blood cell of motion and blood plasma MDA, improves the vigor of GSH-Px.
Glutamine is the amino acid that in blood plasma and skeletal muscle, content is the abundantest, account for more than 60% of muscular free amino acid, the skeletal muscle of people is the main portions of glutamine synthesis and storage, research display keeps muscle GLN concentration to be conducive to muscle DNA and protein synthesis, promote glucose/glycogen metabolism, increase muscular contraction force; Prevent the minimizing of glutathione caused by overexercise, improve oxidation resistance; Glutamine participates in urea and HC0 directly as the carrier of ammonia 3 -generation, maintain acid-base balance in body; Energy substance consumption can be slowed down, activated lymphocyte and macrophage, increase immunity of organisms.
Arginine is the precursor of NO, plays many important function at the volley, and modern medicine study shows that NO has obvious facilitation to nerve signal transmission, contraction of muscle, also can promote the diastole of blood vessel; Arginine can promote that in human body, endogenous hormone is as the secretion of growth hormone, insulin, hyperglycemic factor in addition, reverse catabolic, promotes anabolism, promotes motion process deutocerebrum RNA and protein synthesis; Arginine take part in ornithine circulation, and ammonia is converted into urea, removes the toxicity of ammonia, has immunity moderation function in addition, reduces infection rate, promotes wound healing, regulates the effects such as body function.
Zinc is one of micro elements needed by human, it to the metabolism of human body, growing etc. plays an important role.Zinc is the key factor determining more than 20 kind of enzyme, coenzyme, and zinc supplementation is conducive to increasing Cu, Zn-SOD, improves the oxidation resistance of body, and maintain the integrality of membrane structure, alleviate body injury during sports fatigue, zinc supplementation can significantly improve locomitivity; Suitable zinc supplementation can also make the increase of NK activity, IL 2secretion level significantly improve, thus improve the immunity of human body.
(3) beneficial effect
The present invention uses theory and the achievement in research of Traditional Chinese Medicine, free radical medical science, Hemorheology, sports biochemistry, and have developed the significant fatigue resistant health food of above-mentioned effect, the component contained by product is medicine and food raw materials.Research process of the present invention, through numerous screening bioactive compounds process, is determined that gadol extract, pueraria root powder, taurine, L-arginine, Glu, zinc gluconate mix by a certain percentage composite, can be given full play to the effect of antifatigue, Synergistic.
Detailed description of the invention
Below in conjunction with embodiment, embodiments of the present invention are described in further detail.Following examples for illustration of the present invention, but can not be used for limiting the scope of the invention.
Embodiment 1:
This health food comprises the raw material of following weight portion: gadol extract 48 parts, taurine 18 parts, pueraria root powder 22 parts, glutamine 2 parts, arginase 12 part, zinc gluconate 2 parts, microcrystalline cellulose 1 part, cornstarch 8 parts, dolomol 1 part.
The preparation method of above-mentioned fatigue resistant health food, comprise the following steps: take each component by formula ratio, first pulverize amino acid, zinc gluconates etc. have the raw material of coarse granule and large crystallization, all raw materials are crossed 90 mesh sieves, mix with equal increments hybrid technology according to formula, cross 40 mesh sieves, put into mixer, stir 25 minutes, cross 30 mesh sieves once, put into mixer again, stir 25 minutes, cross 30 mesh sieves once, mixing powder, add again in mixer, add the ethanol of the volumetric concentration 90% accounting for total amount 10%, be uniformly mixed granulation 25 minutes, cross 20 mesh sieves, 90 DEG C of oven dry, cross 20 mesh sieves, whole grain obtains batch mixing, add magnesium, mixing and stirring, be pressed into tablet.
Embodiment 2:
This health food comprises the raw material of following weight portion: gadol extract 45 parts, taurine 18 parts, pueraria root powder 22 parts, glutamine 1 part, arginase 12 part, zinc gluconate 1 part, microcrystalline cellulose 1 part, cornstarch 7 parts, dolomol 1 part.
The preparation method of above-mentioned fatigue resistant health food, comprise the following steps: take each component by formula ratio, first pulverize amino acid, zinc gluconates etc. have the raw material of coarse granule and large crystallization, all raw materials are crossed 80 mesh sieves, mix with equal increments hybrid technology according to formula, cross 20 mesh sieves, put into mixer, stir 15 minutes, cross 20 mesh sieves once, put into mixer again, stir 15 minutes, cross 20 mesh sieves once, mixing powder, add again in mixer, add the ethanol of the volumetric concentration 70% accounting for total amount 5%, be uniformly mixed granulation 15 minutes, cross 10 mesh sieves, 60 DEG C of oven dry, cross 10 mesh sieves, whole grain obtains batch mixing, add magnesium, mixing and stirring, be pressed into tablet.
Embodiment 3:
This health food comprises the raw material of following weight portion: gadol extract 48 parts, taurine 20 parts, pueraria root powder 25 parts, glutamine 2 parts, arginase 12 .5 part, zinc gluconate 2 parts, microcrystalline cellulose 1.5 parts, cornstarch 8 parts, dolomol 1.2 parts.
The preparation method of above-mentioned fatigue resistant health food, comprise the following steps: take each component by formula ratio, first pulverize amino acid, zinc gluconates etc. have the raw material of coarse granule and large crystallization, all raw materials are crossed 100 mesh sieves, mix with equal increments hybrid technology according to formula, cross 60 mesh sieves, put into mixer, stir 30 minutes, cross 40 mesh sieves once, put into mixer again, stir 30 minutes, cross 40 mesh sieves once, mixing powder, add again in mixer, add the ethanol of the volumetric concentration 95% accounting for total amount 15%, be uniformly mixed granulation 30 minutes, cross 30 mesh sieves, 100 DEG C of oven dry, cross 30 mesh sieves, whole grain obtains batch mixing, add magnesium, mixing and stirring, be pressed into tablet.
Embodiment 4:
Compared with embodiment 1, distinctive points is only, in the present embodiment, concrete formula is as follows:
This health food comprises the raw material of following weight portion: gadol extract 40 parts, taurine 16 parts, pueraria root powder 22 parts, glutamine 1 part, arginine 1 part, zinc gluconate 1 part, microcrystalline cellulose 1 part, cornstarch 7 parts, dolomol 1 part.
Embodiment 5:
Compared with embodiment 1, distinctive points is only, in the present embodiment, concrete formula is as follows:
This health food comprises the raw material of following weight portion: gadol extract 55 parts, taurine 23 parts, pueraria root powder 28 parts, glutamine 3 parts, arginine 3 parts, zinc gluconate 2.2 parts, microcrystalline cellulose 2 parts, cornstarch 11 parts, dolomol 1.5 parts.
Embodiment 6:
Compared with embodiment 1, distinctive points is only, in the present embodiment, concrete formula is as follows:
This health food comprises the raw material of following weight portion: gadol extract 30 parts, taurine 7 parts, pueraria root powder 20 parts, glutamine 1 part, arginine 1 part, zinc gluconate 1 part, microcrystalline cellulose 1 part, cornstarch 6 parts, dolomol 1 part.
Embodiment 7:
Compared with embodiment 1, distinctive points is only, in the present embodiment, concrete formula is as follows:
This health food comprises the raw material of following weight portion: gadol extract 70 parts, taurine 26 parts, pueraria root powder 30 parts, glutamine 4 parts, arginine 4 parts, zinc gluconate 2.5 parts, microcrystalline cellulose 3 parts, cornstarch 15 parts, dolomol 1.8 parts.
Test example 1:
Health food obtained for embodiment 3,6 is carried out edible safety and Ergonomy test, test according to " health food inspection and assessment technical specification (2003 editions) " content.Result is as follows:
One, safety toxicology test
(1), acute toxicity test
1. sample: the sample prepared by formula and technique described in embodiment 3,6.
2. animal used as test: SPF level Kunming mouse.
3. its mouse oral acute toxicity test (MTD): embodiment 3,6 is tested, be divided into two groups, often group selects 18 ~ 22gSPF level Kunming mouse 20, male and female half and half, with the dosage per os secondary gavage of 20g/kgBW, Continuous Observation 14 days after administration.Record poisoning manifestations and death condition.
4. result: with the mouse of dosage gavage two kinds of sexes of 20g/kgBW, observe 14 days, result is shown in table 1.Experimental session has no obvious poisoning manifestations, without dead in the observation period.The acute oral toxicity (MTD) of tested material to the mouse of two kinds of sexes is all greater than 20g/kgBW, according to " toxicological evaluation of food safety procedure and method " (version in 2003) acute toxicity classification, belongs to nontoxic level.
Table 1: the acute toxicity tests of sample mouse
(2), 30 days feeding trials
1. sample: the sample prepared by formula and technique described in embodiment 3,6.People's plan dosage is 4.0g/50kgBW day.
2. animal used as test: be divided into two groups, often group selects body weight 50 ~ 60g, SD rat 60, male and female half and half.
3. test method: be divided into two echelons, rat is divided into three tested material groups and a control group by every echelon at random, often organizes 20, male and female half and half.
Control group is fed and is raised arm's length basis block material, and tested material group is then fed and raised and mix various dose sample, and dose design is: basic, normal, high dosage component is not 1,2,4g/kgBW (being equivalent to 25 times of people's plan dosage, 50 times, 100 times respectively).Continuous Observation 30 days.
4. observation index and result
4.1 ordinary circumstances are observed:
Observe the performance of animal, behavior, toxic manifestations and death condition every day.Weigh weekly 1 time and food intake dose twice, calculate weekly food utilization and total food utilization.The each treated animal of result grows, activity is all normal, without poisoning manifestations and death, each treated animal is body weight, weekly body weight evolution, weekly food-intake and food utilization weekly weekly, and TBW recruitment, total food-intake and the equal no difference of science of statistics of total foodstuff utilization rate (P>0.05).
4.2 hematological examinations:
Measuring hemoglobin content (Hgb), red blood cell (RBC) and leucocyte (WBC) count, leukocyte differential count (lymph, monokaryon, neutral grain, addicted to acid, basophilic).Experiment latter stage, hematological indices was all in range of normal value, and each treated animal hemoglobin, red blood cell and white blood cell count(WBC), leukocyte differential count be equal no difference of science of statistics (P>0.05) compared with control group.
4.3 Biochemical Indexes:
Measure serum alanine aminotransferase (ALT), aspartate amino transferase (AST), urea nitrogen (BUN), cholesterol (CHO), triglycerides (TG), blood sugar (GLU), total protein (TP), albumin (ALB), creatinine (CRE).The every biochemical indicator of experiment experimental animal in latter stage is all in range of normal value, and each treated animal blood biochemistry index is equal no difference of science of statistics (P>0.05) compared with control group.
4.4 gross examination of skeletal muscle and pathologic diagnosis:
Test cervical dislocation in latter stage puts to death animal, observes each main organs and chest, abdominal cavity general pathology changes.Take out liver, kidney, spleen, the testis of all animals, weigh and calculate organ coefficient.Take out the liver of control group and high dose group animal, kidney, spleen, testis (or ovary), stomach and duodenum, fix with 12% formalin, FFPE, section, HE dyeing, carry out histological examination under light microscopic.Each main organs (heart, liver, spleen, lung, kidney, stomach, intestines etc.) is showed no significant pathological change.
Above-mentioned acute toxicity test and 30 days feeding trial results show that this product belongs to nontoxic level, can long-term taking.
Two, Ergonomy test
1. sample: the sample prepared by formula and technique described in embodiment 3,6.Negative controls is rhodiola root Maca composite sheet, and its formula is gadol extract 48 parts, pueraria root powder 42 parts, microcrystalline cellulose 1 part, cornstarch 8 parts, dolomol 1 part.
2. animal used as test: SPF level healthy NIH kind male mice 240, body weight is 18 ~ 22 grams.
3. experimental technique
Embodiment 3,6 is tested, is divided into two groups.Often group is according to the oral recommendation consumption of people, if the basic, normal, high dosage component of sample is other 100,200,400mg/kgBW (be equivalent to respectively 5,10,20 times that human body recommends consumption), separately establish a negative control group, often organize 10 animals.Take 1,2,4 grams, embodiment 3,6 sample respectively and respectively add pure water to 200ml, mixing, be made into 5,10,20mg/mL strength solution, corresponding dosage treated animal gavage is given by the volume of 0.2mL/10gBW, negative control group (full moringa powder sheet) gives isopyknic pure water, every day gavage once, continuous gavage measures every alleviating physical fatigue functional parameter after 30 days.
4, observation index
4.1 impacts on Mouse Weight
After per os gives the sample 30d of mouse various dose, experiment initial stage, experiment mid-term, the Mouse Weight of experiment embodiment 3,6 sample in latter stage each dosage group and the body weight of experimental session mouse increase and comparing between negative control group, there are no significant for difference (P > 0.05), shows that embodiment 3,6 sample increases the body weight of mouse and have no significant effect.
4.2 impacts on the mice burden swimming time
Table 2: the walking weight load of each group mouse
Note a:P<0.01, b:P > 0.05; C:P<0.05
As seen from Table 2, heavy burden (6%) swimming time of embodiment 3,6 sample each dosage group mouse is all than the prolongation of negative control group, and the difference of high dose group and negative control group has very significant (P<0.01), show that embodiment 3,6 has the effect of the walking weight load extending mouse.
4.3 impacts on the serum urea level after mouse movement
Table 3: the serum urea measurement result after each group mouse movement
Note a:P<0.01, b:P > 0.05; C:P<0.05
As seen from Table 3, the serum urea content of embodiment 3,6 sample each dosage group mouse is all lower than control group, and the difference of high dose group and negative control group has conspicuousness (P<0.05), show that embodiment 3,6 can reduce the generation of tired mice serum urea.
4.4 impacts on the blood lactase acid value after mouse movement
Table 4: blood lactase acid (mg/L) TG-AUC after each group mouse movement
Note a:P<0.01, b:P > 0.05; C:P<0.05
As seen from Table 4,3 time point blood lactase acid TG-AUCs of each dosage of sample are all less than negative control group, and the difference of high dose group and negative control group has very significant P<0.01), show this sample can reduce mouse movement after blood lactase acid TG-AUC.
4.5 functional evaluation results
Experimental result shows, respectively with 100,200, embodiment 3,6 sample of 400mg/kgBW (being equivalent to human body recommended amounts 5,10,20 times respectively) dosage is to the continuous gavage of mouse 30 days, the walking weight load of mouse can be extended, the generation of tired mice serum urea can be reduced, reduce the blood lactase acid TG-AUC after mouse movement, the body weight of mouse is increased and has no significant effect, show that embodiment 3,6 sample has the function of alleviating physical fatigue, than negative controls (rhodiola root Maca composite sheet) good health care effect.
Above embodiment is only for illustration of the present invention, but not limitation of the present invention.Although with reference to embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that, various combination, amendment or equivalent replacement are carried out to technical scheme of the present invention, do not depart from the spirit and scope of technical solution of the present invention, all should be encompassed in the middle of right of the present invention.

Claims (10)

1. a fatigue resistant health food; it is characterized in that; this health food comprises the raw material of following weight portion: gadol extract 15-90 part, taurine 1-40 part, pueraria root powder 10-40 part; glutamine 0-7 part; arginine 0-6 part, zinc gluconate 0-4 part, microcrystalline cellulose 0-5 part; auxiliary material 0-20 part, lubricant 0-2 part.
2. fatigue resistant health food according to claim 1; it is characterized in that; described health food comprises the raw material of following weight portion: gadol extract 25-80 part, taurine 3-30 part, pueraria root powder 15-35 part; glutamine 1-5 part; arginine 1-5 part, zinc gluconate 1-3 part, microcrystalline cellulose 1-4 part; auxiliary material 4-19 part, lubricant 1-2 part.
3. fatigue resistant health food according to claim 1; it is characterized in that; described health food comprises the raw material of following weight portion: gadol extract 30-70 part, taurine 7-26 part, pueraria root powder 20-30 part; glutamine 1-4 part; arginine 1-4 part, zinc gluconate 1-2.5 part, microcrystalline cellulose 1-3 part; auxiliary material 6-15 part, lubricant 1-1.8 part.
4. fatigue resistant health food according to claim 1; it is characterized in that; described health food comprises the raw material of following weight portion: gadol extract 40-55 part, taurine 16-23 part, pueraria root powder 22-28 part; glutamine 1-3 part; arginine 1-3 part, zinc gluconate 1-2.2 part, microcrystalline cellulose 1-2 part; auxiliary material 7-11 part, lubricant 1-1.5 part.
5. fatigue resistant health food according to claim 1; it is characterized in that; described health food comprises the raw material of following weight portion: gadol extract 45-48 part, taurine 18-20 part, pueraria root powder 22-25 part; glutamine 1-2 part; arginase 12-2.5 parts, zinc gluconate 1-2 part, microcrystalline cellulose 1-1.5 part; auxiliary material 7-8 part, lubricant 1-1.2 part.
6. fatigue resistant health food according to claim 1; it is characterized in that; described health food comprises the raw material of following weight portion: gadol extract 48 parts; taurine 18 parts; pueraria root powder 22 parts; glutamine 2 parts, arginase 12 part, zinc gluconate 2 parts, microcrystalline cellulose 1 part, auxiliary material 8 parts, lubricant 1 part.
7. according to the fatigue resistant health food of any one of claim 1-6, it is characterized in that, described auxiliary material is cornstarch.
8. according to the fatigue resistant health food of any one of claim 1-6, it is characterized in that, described lubricant is dolomol.
9. according to the fatigue resistant health food of any one of claim 1-6, it is characterized in that, Determination of Salidroside >=3% of described gadol extract.
10. the preparation method of the fatigue resistant health food of any one of claim 1-9, it is characterized in that, the method comprising the steps of: take raw material according to weight portion, bulk or coarse raw material are pulverized, all raw materials are crossed 80-100 mesh sieve, mix with equal increments hybrid technology according to formula, cross 20-60 mesh sieve, put into mixer to stir, mixing time 15-30 minute, cross 20-40 mesh sieve, put into mixer Homogeneous phase mixing again, mixing time 15-30 minute, after 20-40 mesh sieve, add the ethanol of the volumetric concentration 70-95% accounting for gross weight 5-15%, be uniformly mixed granulation 15-30 minute, cross 10-30 mesh sieve, 60-100 DEG C of oven dry, batch mixing is obtained after the whole grain of 10-30 mesh sieve, add the lubricant of formula ratio, mixing and stirring, be pressed into sheet.
CN201510641879.2A 2015-09-30 2015-09-30 A kind of fatigue resistant health food and preparation method thereof Pending CN105211856A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106108016A (en) * 2016-06-28 2016-11-16 广州市赛健生物科技有限公司 A kind of health food for relieving physical fatigue and preparation method thereof
CN106307515A (en) * 2016-08-29 2017-01-11 张子亮 Fatigue resistant food and preparing method thereof

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CN1546087A (en) * 2003-12-01 2004-11-17 上海交大昂立股份有限公司 Heart and brain nourishing products consisted of gadol mainly and its preparation
CN1759761A (en) * 2005-09-30 2006-04-19 北京康比特威创体育新技术发展有限公司 Beverage for promoting sportive recovery from fatigue
CN103005435A (en) * 2012-12-13 2013-04-03 北京康比特体育科技股份有限公司 Anti-fatigue composition capable of improving speed endurance and preparation containing anti-fatigue composition
CN103948039A (en) * 2014-05-14 2014-07-30 郭友用 Health-care food with function of relieving physical fatigue and preparation method of health-care food
CN104257717A (en) * 2014-10-13 2015-01-07 昆明固康保健品有限公司 Preparation of high-activity Maca extract as well as compound preparation formula and application of Maca extract

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1546087A (en) * 2003-12-01 2004-11-17 上海交大昂立股份有限公司 Heart and brain nourishing products consisted of gadol mainly and its preparation
CN1759761A (en) * 2005-09-30 2006-04-19 北京康比特威创体育新技术发展有限公司 Beverage for promoting sportive recovery from fatigue
CN103005435A (en) * 2012-12-13 2013-04-03 北京康比特体育科技股份有限公司 Anti-fatigue composition capable of improving speed endurance and preparation containing anti-fatigue composition
CN103948039A (en) * 2014-05-14 2014-07-30 郭友用 Health-care food with function of relieving physical fatigue and preparation method of health-care food
CN104257717A (en) * 2014-10-13 2015-01-07 昆明固康保健品有限公司 Preparation of high-activity Maca extract as well as compound preparation formula and application of Maca extract

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106108016A (en) * 2016-06-28 2016-11-16 广州市赛健生物科技有限公司 A kind of health food for relieving physical fatigue and preparation method thereof
CN106307515A (en) * 2016-08-29 2017-01-11 张子亮 Fatigue resistant food and preparing method thereof

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