CN105211856A - A kind of fatigue resistant health food and preparation method thereof - Google Patents
A kind of fatigue resistant health food and preparation method thereof Download PDFInfo
- Publication number
- CN105211856A CN105211856A CN201510641879.2A CN201510641879A CN105211856A CN 105211856 A CN105211856 A CN 105211856A CN 201510641879 A CN201510641879 A CN 201510641879A CN 105211856 A CN105211856 A CN 105211856A
- Authority
- CN
- China
- Prior art keywords
- health food
- parts
- raw material
- fatigue resistant
- lubricant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 235000013402 health food Nutrition 0.000 title claims abstract description 47
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- XOAAWQZATWQOTB-UHFFFAOYSA-N Taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims abstract description 56
- 239000002994 raw material Substances 0.000 claims abstract description 37
- 229960003080 Taurine Drugs 0.000 claims abstract description 28
- 239000000843 powder Substances 0.000 claims abstract description 26
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims abstract description 24
- 235000011478 zinc gluconate Nutrition 0.000 claims abstract description 24
- 238000002156 mixing Methods 0.000 claims abstract description 23
- 241000219780 Pueraria Species 0.000 claims abstract description 22
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims abstract description 21
- 229960000306 Zinc Gluconate Drugs 0.000 claims abstract description 21
- WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 claims abstract description 21
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims abstract description 21
- 239000008108 microcrystalline cellulose Substances 0.000 claims abstract description 21
- 229940016286 microcrystalline cellulose Drugs 0.000 claims abstract description 21
- 239000011670 zinc gluconate Substances 0.000 claims abstract description 21
- 239000000463 material Substances 0.000 claims abstract description 19
- 239000000314 lubricant Substances 0.000 claims abstract description 18
- 239000004475 Arginine Substances 0.000 claims abstract description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 16
- 238000003756 stirring Methods 0.000 claims abstract description 14
- 239000000203 mixture Substances 0.000 claims abstract description 13
- 238000005516 engineering process Methods 0.000 claims abstract description 7
- 238000005469 granulation Methods 0.000 claims abstract description 6
- 230000003179 granulation Effects 0.000 claims abstract description 6
- 235000020985 whole grains Nutrition 0.000 claims abstract description 6
- 229920002261 Corn starch Polymers 0.000 claims description 10
- 239000008120 corn starch Substances 0.000 claims description 10
- 229940099112 cornstarch Drugs 0.000 claims description 10
- RZVAJINKPMORJF-UHFFFAOYSA-N p-acetaminophenol Chemical group CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims description 10
- 102000004452 Arginases Human genes 0.000 claims description 7
- 108020001204 Arginases Proteins 0.000 claims description 7
- ILRCGYURZSFMEG-RKQHYHRCSA-N Rhodioloside Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OCCC1=CC=C(O)C=C1 ILRCGYURZSFMEG-RKQHYHRCSA-N 0.000 claims description 4
- 230000000694 effects Effects 0.000 abstract description 25
- 230000002929 anti-fatigue Effects 0.000 abstract description 10
- 230000002195 synergetic Effects 0.000 abstract description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 14
- 210000004369 Blood Anatomy 0.000 description 12
- 239000008280 blood Substances 0.000 description 12
- 235000001014 amino acid Nutrition 0.000 description 11
- 235000009697 arginine Nutrition 0.000 description 11
- 150000001413 amino acids Chemical class 0.000 description 10
- 239000002253 acid Substances 0.000 description 9
- 238000000034 method Methods 0.000 description 9
- 230000037396 body weight Effects 0.000 description 8
- 241000700159 Rattus Species 0.000 description 7
- 239000004202 carbamide Substances 0.000 description 7
- 235000013305 food Nutrition 0.000 description 7
- 229940096919 Glycogen Drugs 0.000 description 6
- 229920002527 Glycogen Polymers 0.000 description 6
- BYSGBSNPRWKUQH-UJDJLXLFSA-N Glycogen Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@@H](O)[C@@H](O[C@@H]2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)O1 BYSGBSNPRWKUQH-UJDJLXLFSA-N 0.000 description 6
- 210000003205 Muscles Anatomy 0.000 description 6
- 210000002966 Serum Anatomy 0.000 description 6
- 229940091251 Zinc Supplements Drugs 0.000 description 6
- 238000003304 gavage Methods 0.000 description 6
- 230000003442 weekly Effects 0.000 description 6
- HCHKCACWOHOZIP-UHFFFAOYSA-N zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 6
- 239000011701 zinc Substances 0.000 description 6
- 229910052725 zinc Inorganic materials 0.000 description 6
- 210000003743 Erythrocytes Anatomy 0.000 description 5
- 102100011343 GLB1 Human genes 0.000 description 5
- 229940116108 Lactase Drugs 0.000 description 5
- 108010059881 Lactase Proteins 0.000 description 5
- 230000036740 Metabolism Effects 0.000 description 5
- 210000002027 Muscle, Skeletal Anatomy 0.000 description 5
- 210000003324 RBC Anatomy 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 230000004060 metabolic process Effects 0.000 description 5
- 230000035786 metabolism Effects 0.000 description 5
- HVYWMOMLDIMFJA-DPAQBDIFSA-N (3β)-Cholest-5-en-3-ol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- 210000004556 Brain Anatomy 0.000 description 4
- 210000004185 Liver Anatomy 0.000 description 4
- 241001165494 Rhodiola Species 0.000 description 4
- 230000034994 death Effects 0.000 description 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 4
- FYYHWMGAXLPEAU-UHFFFAOYSA-N magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 4
- 239000011777 magnesium Substances 0.000 description 4
- 229910052749 magnesium Inorganic materials 0.000 description 4
- 210000000056 organs Anatomy 0.000 description 4
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 241000208340 Araliaceae Species 0.000 description 3
- 210000002216 Heart Anatomy 0.000 description 3
- 102000001554 Hemoglobins Human genes 0.000 description 3
- 108010054147 Hemoglobins Proteins 0.000 description 3
- 206010022114 Injury Diseases 0.000 description 3
- 210000003734 Kidney Anatomy 0.000 description 3
- 210000000265 Leukocytes Anatomy 0.000 description 3
- 235000003140 Panax quinquefolius Nutrition 0.000 description 3
- 210000000952 Spleen Anatomy 0.000 description 3
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 3
- 238000011047 acute toxicity test Methods 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 3
- 239000002131 composite material Substances 0.000 description 3
- 238000002425 crystallisation Methods 0.000 description 3
- 230000005712 crystallization Effects 0.000 description 3
- 235000012631 food intake Nutrition 0.000 description 3
- 230000037406 food intake Effects 0.000 description 3
- 235000005035 ginseng Nutrition 0.000 description 3
- 235000008434 ginseng Nutrition 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 230000036039 immunity Effects 0.000 description 3
- 238000011068 load Methods 0.000 description 3
- 230000003647 oxidation Effects 0.000 description 3
- 238000007254 oxidation reaction Methods 0.000 description 3
- 231100000572 poisoning Toxicity 0.000 description 3
- 230000000607 poisoning Effects 0.000 description 3
- 235000018102 proteins Nutrition 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 230000001502 supplementation Effects 0.000 description 3
- 102100001249 ALB Human genes 0.000 description 2
- 101710027066 ALB Proteins 0.000 description 2
- 206010001497 Agitation Diseases 0.000 description 2
- 108010082126 Alanine Transaminase Proteins 0.000 description 2
- 108010003415 Aspartate Aminotransferases Proteins 0.000 description 2
- 102000004625 Aspartate Aminotransferases Human genes 0.000 description 2
- 229940107161 Cholesterol Drugs 0.000 description 2
- 229940109239 Creatinine Drugs 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N D-Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 102100010966 GPT Human genes 0.000 description 2
- 102000006587 Glutathione Peroxidase Human genes 0.000 description 2
- 108020004973 Glutathione Peroxidase Proteins 0.000 description 2
- 102000004877 Insulin Human genes 0.000 description 2
- 108090001061 Insulin Proteins 0.000 description 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 2
- 240000000759 Lepidium meyenii Species 0.000 description 2
- 235000000421 Lepidium meyenii Nutrition 0.000 description 2
- OYHQOLUKZRVURQ-IXWMQOLASA-N Linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 2
- 230000036882 MTD Effects 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 210000004413 Myocytes, Cardiac Anatomy 0.000 description 2
- 210000001672 Ovary Anatomy 0.000 description 2
- 210000002381 Plasma Anatomy 0.000 description 2
- 229940076279 Serotonin Drugs 0.000 description 2
- 210000002784 Stomach Anatomy 0.000 description 2
- 210000001550 Testis Anatomy 0.000 description 2
- PNNCWTXUWKENPE-UHFFFAOYSA-N [N].NC(N)=O Chemical compound [N].NC(N)=O PNNCWTXUWKENPE-UHFFFAOYSA-N 0.000 description 2
- 231100000460 acute oral toxicity Toxicity 0.000 description 2
- 229940050528 albumin Drugs 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 2
- 229920003013 deoxyribonucleic acid Polymers 0.000 description 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 2
- 230000003203 everyday Effects 0.000 description 2
- 230000005284 excitation Effects 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000002489 hematologic Effects 0.000 description 2
- 210000002865 immune cell Anatomy 0.000 description 2
- 230000001965 increased Effects 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 239000004310 lactic acid Substances 0.000 description 2
- 235000014655 lactic acid Nutrition 0.000 description 2
- 235000012902 lepidium meyenii Nutrition 0.000 description 2
- 230000003340 mental Effects 0.000 description 2
- 230000002107 myocardial Effects 0.000 description 2
- 230000003000 nontoxic Effects 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000001243 protein synthesis Methods 0.000 description 2
- 230000001603 reducing Effects 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- 230000014616 translation Effects 0.000 description 2
- 150000003626 triacylglycerols Chemical class 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- DTOSIQBPPRVQHS-PDBXOOCHSA-N α-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 description 2
- OCUSNPIJIZCRSZ-ZTZWCFDHSA-N (2S)-2-amino-3-methylbutanoic acid;(2S)-2-amino-4-methylpentanoic acid;(2S,3S)-2-amino-3-methylpentanoic acid Chemical class CC(C)[C@H](N)C(O)=O.CC[C@H](C)[C@H](N)C(O)=O.CC(C)C[C@H](N)C(O)=O OCUSNPIJIZCRSZ-ZTZWCFDHSA-N 0.000 description 1
- 229920000160 (ribonucleotides)n+m Polymers 0.000 description 1
- 229940030486 ANDROGENS Drugs 0.000 description 1
- 210000000683 Abdominal Cavity Anatomy 0.000 description 1
- ZKHQWZAMYRWXGA-KQYNXXCUSA-N Adenosine triphosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-N 0.000 description 1
- 210000004100 Adrenal Glands Anatomy 0.000 description 1
- 208000007502 Anemia Diseases 0.000 description 1
- 206010002660 Anoxia Diseases 0.000 description 1
- 241000976983 Anoxia Species 0.000 description 1
- 210000004204 Blood Vessels Anatomy 0.000 description 1
- 241000219193 Brassicaceae Species 0.000 description 1
- 210000003169 Central Nervous System Anatomy 0.000 description 1
- 206010008088 Cerebral artery embolism Diseases 0.000 description 1
- 230000035700 Clearance Rate Effects 0.000 description 1
- 206010010264 Condition aggravated Diseases 0.000 description 1
- 210000001198 Duodenum Anatomy 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 229940088598 Enzyme Drugs 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- RWSXRVCMGQZWBV-WDSKDSINSA-N Glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 1
- 229960003180 Glutathione Drugs 0.000 description 1
- 108010024636 Glutathione Proteins 0.000 description 1
- 102000018997 Growth Hormone Human genes 0.000 description 1
- 108010051696 Growth Hormone Proteins 0.000 description 1
- 229940088597 Hormone Drugs 0.000 description 1
- 206010020651 Hyperkinesia Diseases 0.000 description 1
- 208000000269 Hyperkinesis Diseases 0.000 description 1
- 206010020993 Hypoglycaemia Diseases 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 210000000936 Intestines Anatomy 0.000 description 1
- 235000014852 L-arginine Nutrition 0.000 description 1
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 description 1
- 229960004488 Linolenic Acid Drugs 0.000 description 1
- 210000004072 Lung Anatomy 0.000 description 1
- 210000002751 Lymph Anatomy 0.000 description 1
- 210000004698 Lymphocytes Anatomy 0.000 description 1
- 210000002540 Macrophages Anatomy 0.000 description 1
- 240000007934 Moringa oleifera Species 0.000 description 1
- 235000011347 Moringa oleifera Nutrition 0.000 description 1
- 208000003067 Myocardial Ischemia Diseases 0.000 description 1
- 210000004165 Myocardium Anatomy 0.000 description 1
- 208000009025 Nervous System Disease Diseases 0.000 description 1
- 229960003104 Ornithine Drugs 0.000 description 1
- 240000007742 Raphanus sativus Species 0.000 description 1
- 235000006140 Raphanus sativus var sativus Nutrition 0.000 description 1
- 240000005648 Rhodiola rosea Species 0.000 description 1
- 235000003713 Rhodiola rosea Nutrition 0.000 description 1
- 210000001541 Thymus Gland Anatomy 0.000 description 1
- 210000001835 Viscera Anatomy 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- UCTWMZQNUQWSLP-UHFFFAOYSA-N adrenaline Chemical compound CNCC(O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-UHFFFAOYSA-N 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 235000020661 alpha-linolenic acid Nutrition 0.000 description 1
- 239000003098 androgen Substances 0.000 description 1
- 230000001548 androgenic Effects 0.000 description 1
- 230000003078 antioxidant Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- -1 aromatic amino acid Chemical class 0.000 description 1
- 230000003143 atherosclerotic Effects 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 230000000975 bioactive Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000001925 catabolic Effects 0.000 description 1
- 210000004027 cells Anatomy 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 239000005515 coenzyme Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000000875 corresponding Effects 0.000 description 1
- 230000002354 daily Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000003111 delayed Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 201000009910 diseases by infectious agent Diseases 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 229960003638 dopamine Drugs 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 229940079593 drugs Drugs 0.000 description 1
- 238000004043 dyeing Methods 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 230000002708 enhancing Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000036545 exercise Effects 0.000 description 1
- 230000035558 fertility Effects 0.000 description 1
- WSFSSNUMVMOOMR-UHFFFAOYSA-N formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 1
- 235000013376 functional food Nutrition 0.000 description 1
- 230000004110 gluconeogenesis Effects 0.000 description 1
- 230000034659 glycolysis Effects 0.000 description 1
- 230000036449 good health Effects 0.000 description 1
- 239000000122 growth hormone Substances 0.000 description 1
- 230000002440 hepatic Effects 0.000 description 1
- 238000010562 histological examination Methods 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 201000001421 hyperglycemia Diseases 0.000 description 1
- 239000000864 hyperglycemic agent Substances 0.000 description 1
- 230000002218 hypoglycaemic Effects 0.000 description 1
- 230000001146 hypoxic Effects 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000003834 intracellular Effects 0.000 description 1
- 201000010849 intracranial embolism Diseases 0.000 description 1
- 230000002147 killing Effects 0.000 description 1
- 230000000670 limiting Effects 0.000 description 1
- 235000020778 linoleic acid Nutrition 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 210000000663 muscle cells Anatomy 0.000 description 1
- 230000004118 muscle contraction Effects 0.000 description 1
- 230000003387 muscular Effects 0.000 description 1
- 210000000107 myocyte Anatomy 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 230000001264 neutralization Effects 0.000 description 1
- 230000036284 oxygen consumption Effects 0.000 description 1
- 230000001575 pathological Effects 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 description 1
- OZAIFHULBGXAKX-UHFFFAOYSA-N precursor Substances N#CC(C)(C)N=NC(C)(C)C#N OZAIFHULBGXAKX-UHFFFAOYSA-N 0.000 description 1
- 230000001737 promoting Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000002829 reduced Effects 0.000 description 1
- 230000001105 regulatory Effects 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 230000000630 rising Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000002194 synthesizing Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000002588 toxic Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 238000009602 toxicology test Methods 0.000 description 1
- 231100000041 toxicology testing Toxicity 0.000 description 1
- 230000001702 transmitter Effects 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N β-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention discloses a kind of fatigue resistant health food; this health food comprises the raw material of following weight portion: gadol extract 15-90 part; taurine 1-40 part; pueraria root powder 10-40 part, glutamine 0-7 part, arginine 0-6 part; zinc gluconate 0-4 part; microcrystalline cellulose 0-5 part, auxiliary material 0-20 part, lubricant 0-2 part.The preparation method of this fatigue resistant health food comprises step: take raw material according to weight portion, bulk or coarse raw material are pulverized, all raw materials are crossed 80-100 mesh sieve, mix with equal increments hybrid technology according to formula, add the ethanol of the volumetric concentration 70-95% accounting for gross weight 5-15%, be uniformly mixed granulation 15-30 minute, cross 10-30 mesh sieve, 60-100 DEG C of oven dry, batch mixing is obtained after the whole grain of 10-30 mesh sieve, add the lubricant of formula ratio, mixing and stirring, be pressed into sheet.The each component Synergistic of health food of the present invention, has significant antifatigue effect.
Description
Technical field
The present invention relates to technical field of health care food, more specifically relate to a kind of fatigue resistant health food and preparation method thereof.
Background technology
Modern society's rhythm is fast, dog-eat-dog, people's operating pressure strengthens, tired crowd significantly rises, psychological pressure causes greatly mental fatigue serious, brain dominates the function of each organ of whole body, long-term mental fatigue will cause viscera function not enough, function declines, body is because producing anaerobic metabolism for hypoxgia, there is too much refuse, as lactic acid, oxygen radical etc., cause nervous system disorder, endocrine disturbance, immunologic function declines, bring out various disease or make original disease aggravation, even cause gloomy, the psychological changes such as agitation, Here it is " falling sick from overwork ", also can cause time serious " overworking broken dead ", human body anoxia metabolism simultaneously produces too much oxygen radical etc. and more can cause damage to cardio-cerebrovascular, cause heart change, atherosclerotic, cerebral embolism etc., and the locomitivity of people can be affected, fatigue is the killer affecting health.Therefore the functional food needing good anti-fatigue effect is intervened.The anti-fatigue effect health food studying effect distinguished has certain value to tired crowd.
Summary of the invention
(1) technical problem that will solve
The technical problem to be solved in the present invention is exactly how to improve the anti-fatigue effect of anti-fatigue effect health food, and provides a kind of fatigue resistant health food and preparation method thereof.
(2) technical scheme
In order to solve the problems of the technologies described above; the invention provides a kind of fatigue resistant health food; this health food comprises the raw material (raw materials used be all commercially available) of following weight portion: gadol extract (buying from Jiahe, Shaanxi) 15-90 part, taurine 1-40 part, pueraria root powder (buying from Dalian Mai Po) 10-40 part; glutamine 0-7 part; arginine 0-6 part, zinc gluconate 0-4 part, microcrystalline cellulose 0-5 part; auxiliary material 0-20 part, lubricant 0-2 part.
Preferably, described health food comprises the raw material of following weight portion: gadol extract 25-80 part, taurine 3-30 part, pueraria root powder 15-35 part; glutamine 1-5 part, arginine 1-5 part, zinc gluconate 1-3 part; microcrystalline cellulose 1-4 part, auxiliary material 4-19 part, lubricant 1-2 part.
Preferably, described health food comprises the raw material of following weight portion: gadol extract 30-70 part, taurine 7-26 part, pueraria root powder 20-30 part; glutamine 1-4 part, arginine 1-4 part, zinc gluconate 1-2.5 part; microcrystalline cellulose 1-3 part, auxiliary material 6-15 part, lubricant 1-1.8 part.
Preferably, described health food comprises the raw material of following weight portion: gadol extract 40-55 part, taurine 16-23 part, pueraria root powder 22-28 part; glutamine 1-3 part, arginine 1-3 part, zinc gluconate 1-2.2 part; microcrystalline cellulose 1-2 part, auxiliary material 7-11 part, lubricant 1-1.5 part.
Preferably, described health food comprises the raw material of following weight portion: gadol extract 45-48 part, taurine 18-20 part, pueraria root powder 22-25 part; glutamine 1-2 part, arginase 12-2.5 parts, zinc gluconate 1-2 part; microcrystalline cellulose 1-1.5 part, auxiliary material 7-8 part, lubricant 1-1.2 part.
Preferably, described health food comprises the raw material of following weight portion: gadol extract 48 parts, taurine 18 parts, pueraria root powder 22 parts, glutamine 2 parts, arginase 12 part, zinc gluconate 2 parts, microcrystalline cellulose 1 part, auxiliary material 8 parts, lubricant 1 part.
Preferably, described auxiliary material is cornstarch.
Preferably, described lubricant is dolomol.
Preferably, Determination of Salidroside >=3% of described gadol extract.
Present invention also offers the preparation method of fatigue resistant health food, the method comprising the steps of: take raw material according to weight portion, bulk or coarse raw material are pulverized, all raw materials are crossed 80-100 mesh sieve, mix with equal increments hybrid technology according to formula, cross 20-60 mesh sieve, put into mixer to stir, mixing time 15-30 minute, cross 20-60 mesh sieve, put into mixer Homogeneous phase mixing again, mixing time 15-30 minute, after 20-40 mesh sieve, (cycle-index is more, effect is better, arrive the fineness limit of mesh sieve adjustment), add the ethanol of the volumetric concentration 70-95% accounting for gross weight 5-15%, be uniformly mixed granulation 15-30 minute, cross 10-40 mesh sieve, 60-100 DEG C of oven dry, after 10-40 mesh sieve, whole grain obtains batch mixing, add the lubricant of formula ratio, mixing and stirring, be pressed into sheet.
In production medicine or food, because each component ratio differs greatly in formula, not easily mix, therefore adopt " equal increments method " effect better.Its concrete operation method is: get the component that the amount of component in a small amount and equivalent is large, be placed in mixing machinery simultaneously and mix, the larger component of the amount adding same mixture equivalent mixes, and times amount like this increases till adding the large component of whole amount.
Rhodiola root has ginseng and the similar effect of wilsonii, but without ginseng strong excitation, easily to get angry the disadvantage of easy constipating effect of phenomenon and wilsonii.Animal experiment proves that rhodiola root has following effect:
(1) protection cardiac muscle, strengthens myocardial contractive power, function of resisting myocardial ischemia;
(2) nervous system excitability can be improved, anti-central nerve fatigue, reduce serotonin in brain caused by hyperkinesia too high, relatively raise the concentration of dopamine;
(3) internal system is regulated, the incretory such as excitement and adjustment adrenal gland, thymus gland and ovary, the hypoglycemia that the hyperglycaemia stoping adrenaline to cause and insulin cause;
(4) enhancing substance metabolism, promotes that the decomposition of Mouse Liver glycogen and muscle glycogen utilizes, improves ATP, DNA and protein level in skeletal muscle;
(5) hemoglobin and red blood cell number in blood can be made to increase, reduce blood urea nitrogen, reduce the content of lactic acid in blood, reduce oxygen consumption rate, extend run duration, resisting kinetic fatigue.Clinical data shows: the fault rate that rhodiola rosea formulated product works under improving muscle power, intelligence, the ability to work of experimenter, particularly tired situation.
Agate coffee, also known as Peru's ginseng, for being similar to the block root class plant of radish, belonging to Cruciferae, originating in the mountain area, Andean of more than height above sea level 4000m in the middle part of Peru.Modern medicine study proves, agate coffee has and strengthens fecundity, improvement function, antifatigue, the pharmacological action such as anti-oxidant.Supplement agate coffee has-Ding effect to the body injury that long-time exhausted movemeat causes, body weight can be suppressed to a certain extent relatively to increase downward trend, improve rat anti-fatigue ability, and then prolong rats run duration, and in dose dependent, but do not have not present with the increase of dosage to increase progressively state significantly to the effect of body injury.Its mechanism may be:
(1) abundant energy supply can be provided for rat containing abundant nutriment [rich in protein (8.87%) and total reducing sugar (19.85%)] in agate coffee.
(2) a large amount of branched-chain amino acids (20.14% total amino acid) and a certain amount of taurine is contained in agate coffee.Tired and the nervous centralis fatigue of branched-chain amino acid and taurine resisted motion all has certain help.
(3) although in agate coffee fat content not high, the ratio of unrighted acid is high especially, and the ratio that the polyunsaturated fatty acid (linoleic acid and alpha-linolenic acid) with various health-care accounts for aliphatic acid reaches 60.3%.There are some researches show, oral unrighted acid can change the distribution of the rear endogenous androgens of motion, androgenic activity after improving tiring exercises, to improving locomitivity and promoting that tired elimination has physiological significance.
(4) in agate coffee, the multiple chemical composition mineral matter with antifatigue effect such as calcium, magnesium, zinc enriches.
(5) reduction of glycogen content is the key factor that body resisting fatigue ability declines.Agate coffee can significantly improve the rear rat muscle glycogen of motion and hepatic glycogen content, for body provides good energy reserve at the volley, thus plays certain antifatigue effect.
Taurine can significantly improve the concentration of branched-chain amino acid in blood (BCAA); aromatic amino acid (AAA) is declined with the ratio of BCAA; AAA is inhibit to operate into brain; serotonin in brain is suppressed to increase; keep central excitation; improve transmitter in central nervous system unbalance, delayed motion fatigue produces.Animal experiment proves that taurine can increase substantially the locomitivity of rat; reduce WBV; reduce packed cell volume and MDA; raise GSH-Px; increase the oxidation resistance of body; increase the clearance rate of free radical; improve anaemia: taurine can also reduce blood sugar; promote that myocyte is to glucose and amino acid whose picked-up and utilization; accelerate glycolysis, increase gluconeogenesis, separately can increase the amino acid whose concentration of energy supply in skeletal muscle; regulate lipid metaboli, these all can alleviate the exhaustion of energy substance in motion process.Taurine also can maintain cardiac muscle cell's intracellular free calcium level, improves cardiac muscle cell's hypoxia-bearing capability, increases myocardial contractive power.Human trial show sportsman daily 400mg taurine carry out 70%V0
2max cycle ergometer moves, and can significantly improve locomitivity compared with control group, promotes the recovery of postexercise heart rate, reduces the rising of the rear red blood cell of motion and blood plasma MDA, improves the vigor of GSH-Px.
Glutamine is the amino acid that in blood plasma and skeletal muscle, content is the abundantest, account for more than 60% of muscular free amino acid, the skeletal muscle of people is the main portions of glutamine synthesis and storage, research display keeps muscle GLN concentration to be conducive to muscle DNA and protein synthesis, promote glucose/glycogen metabolism, increase muscular contraction force; Prevent the minimizing of glutathione caused by overexercise, improve oxidation resistance; Glutamine participates in urea and HC0 directly as the carrier of ammonia
3 -generation, maintain acid-base balance in body; Energy substance consumption can be slowed down, activated lymphocyte and macrophage, increase immunity of organisms.
Arginine is the precursor of NO, plays many important function at the volley, and modern medicine study shows that NO has obvious facilitation to nerve signal transmission, contraction of muscle, also can promote the diastole of blood vessel; Arginine can promote that in human body, endogenous hormone is as the secretion of growth hormone, insulin, hyperglycemic factor in addition, reverse catabolic, promotes anabolism, promotes motion process deutocerebrum RNA and protein synthesis; Arginine take part in ornithine circulation, and ammonia is converted into urea, removes the toxicity of ammonia, has immunity moderation function in addition, reduces infection rate, promotes wound healing, regulates the effects such as body function.
Zinc is one of micro elements needed by human, it to the metabolism of human body, growing etc. plays an important role.Zinc is the key factor determining more than 20 kind of enzyme, coenzyme, and zinc supplementation is conducive to increasing Cu, Zn-SOD, improves the oxidation resistance of body, and maintain the integrality of membrane structure, alleviate body injury during sports fatigue, zinc supplementation can significantly improve locomitivity; Suitable zinc supplementation can also make the increase of NK activity, IL
2secretion level significantly improve, thus improve the immunity of human body.
(3) beneficial effect
The present invention uses theory and the achievement in research of Traditional Chinese Medicine, free radical medical science, Hemorheology, sports biochemistry, and have developed the significant fatigue resistant health food of above-mentioned effect, the component contained by product is medicine and food raw materials.Research process of the present invention, through numerous screening bioactive compounds process, is determined that gadol extract, pueraria root powder, taurine, L-arginine, Glu, zinc gluconate mix by a certain percentage composite, can be given full play to the effect of antifatigue, Synergistic.
Detailed description of the invention
Below in conjunction with embodiment, embodiments of the present invention are described in further detail.Following examples for illustration of the present invention, but can not be used for limiting the scope of the invention.
Embodiment 1:
This health food comprises the raw material of following weight portion: gadol extract 48 parts, taurine 18 parts, pueraria root powder 22 parts, glutamine 2 parts, arginase 12 part, zinc gluconate 2 parts, microcrystalline cellulose 1 part, cornstarch 8 parts, dolomol 1 part.
The preparation method of above-mentioned fatigue resistant health food, comprise the following steps: take each component by formula ratio, first pulverize amino acid, zinc gluconates etc. have the raw material of coarse granule and large crystallization, all raw materials are crossed 90 mesh sieves, mix with equal increments hybrid technology according to formula, cross 40 mesh sieves, put into mixer, stir 25 minutes, cross 30 mesh sieves once, put into mixer again, stir 25 minutes, cross 30 mesh sieves once, mixing powder, add again in mixer, add the ethanol of the volumetric concentration 90% accounting for total amount 10%, be uniformly mixed granulation 25 minutes, cross 20 mesh sieves, 90 DEG C of oven dry, cross 20 mesh sieves, whole grain obtains batch mixing, add magnesium, mixing and stirring, be pressed into tablet.
Embodiment 2:
This health food comprises the raw material of following weight portion: gadol extract 45 parts, taurine 18 parts, pueraria root powder 22 parts, glutamine 1 part, arginase 12 part, zinc gluconate 1 part, microcrystalline cellulose 1 part, cornstarch 7 parts, dolomol 1 part.
The preparation method of above-mentioned fatigue resistant health food, comprise the following steps: take each component by formula ratio, first pulverize amino acid, zinc gluconates etc. have the raw material of coarse granule and large crystallization, all raw materials are crossed 80 mesh sieves, mix with equal increments hybrid technology according to formula, cross 20 mesh sieves, put into mixer, stir 15 minutes, cross 20 mesh sieves once, put into mixer again, stir 15 minutes, cross 20 mesh sieves once, mixing powder, add again in mixer, add the ethanol of the volumetric concentration 70% accounting for total amount 5%, be uniformly mixed granulation 15 minutes, cross 10 mesh sieves, 60 DEG C of oven dry, cross 10 mesh sieves, whole grain obtains batch mixing, add magnesium, mixing and stirring, be pressed into tablet.
Embodiment 3:
This health food comprises the raw material of following weight portion: gadol extract 48 parts, taurine 20 parts, pueraria root powder 25 parts, glutamine 2 parts, arginase 12 .5 part, zinc gluconate 2 parts, microcrystalline cellulose 1.5 parts, cornstarch 8 parts, dolomol 1.2 parts.
The preparation method of above-mentioned fatigue resistant health food, comprise the following steps: take each component by formula ratio, first pulverize amino acid, zinc gluconates etc. have the raw material of coarse granule and large crystallization, all raw materials are crossed 100 mesh sieves, mix with equal increments hybrid technology according to formula, cross 60 mesh sieves, put into mixer, stir 30 minutes, cross 40 mesh sieves once, put into mixer again, stir 30 minutes, cross 40 mesh sieves once, mixing powder, add again in mixer, add the ethanol of the volumetric concentration 95% accounting for total amount 15%, be uniformly mixed granulation 30 minutes, cross 30 mesh sieves, 100 DEG C of oven dry, cross 30 mesh sieves, whole grain obtains batch mixing, add magnesium, mixing and stirring, be pressed into tablet.
Embodiment 4:
Compared with embodiment 1, distinctive points is only, in the present embodiment, concrete formula is as follows:
This health food comprises the raw material of following weight portion: gadol extract 40 parts, taurine 16 parts, pueraria root powder 22 parts, glutamine 1 part, arginine 1 part, zinc gluconate 1 part, microcrystalline cellulose 1 part, cornstarch 7 parts, dolomol 1 part.
Embodiment 5:
Compared with embodiment 1, distinctive points is only, in the present embodiment, concrete formula is as follows:
This health food comprises the raw material of following weight portion: gadol extract 55 parts, taurine 23 parts, pueraria root powder 28 parts, glutamine 3 parts, arginine 3 parts, zinc gluconate 2.2 parts, microcrystalline cellulose 2 parts, cornstarch 11 parts, dolomol 1.5 parts.
Embodiment 6:
Compared with embodiment 1, distinctive points is only, in the present embodiment, concrete formula is as follows:
This health food comprises the raw material of following weight portion: gadol extract 30 parts, taurine 7 parts, pueraria root powder 20 parts, glutamine 1 part, arginine 1 part, zinc gluconate 1 part, microcrystalline cellulose 1 part, cornstarch 6 parts, dolomol 1 part.
Embodiment 7:
Compared with embodiment 1, distinctive points is only, in the present embodiment, concrete formula is as follows:
This health food comprises the raw material of following weight portion: gadol extract 70 parts, taurine 26 parts, pueraria root powder 30 parts, glutamine 4 parts, arginine 4 parts, zinc gluconate 2.5 parts, microcrystalline cellulose 3 parts, cornstarch 15 parts, dolomol 1.8 parts.
Test example 1:
Health food obtained for embodiment 3,6 is carried out edible safety and Ergonomy test, test according to " health food inspection and assessment technical specification (2003 editions) " content.Result is as follows:
One, safety toxicology test
(1), acute toxicity test
1. sample: the sample prepared by formula and technique described in embodiment 3,6.
2. animal used as test: SPF level Kunming mouse.
3. its mouse oral acute toxicity test (MTD): embodiment 3,6 is tested, be divided into two groups, often group selects 18 ~ 22gSPF level Kunming mouse 20, male and female half and half, with the dosage per os secondary gavage of 20g/kgBW, Continuous Observation 14 days after administration.Record poisoning manifestations and death condition.
4. result: with the mouse of dosage gavage two kinds of sexes of 20g/kgBW, observe 14 days, result is shown in table 1.Experimental session has no obvious poisoning manifestations, without dead in the observation period.The acute oral toxicity (MTD) of tested material to the mouse of two kinds of sexes is all greater than 20g/kgBW, according to " toxicological evaluation of food safety procedure and method " (version in 2003) acute toxicity classification, belongs to nontoxic level.
Table 1: the acute toxicity tests of sample mouse
(2), 30 days feeding trials
1. sample: the sample prepared by formula and technique described in embodiment 3,6.People's plan dosage is 4.0g/50kgBW day.
2. animal used as test: be divided into two groups, often group selects body weight 50 ~ 60g, SD rat 60, male and female half and half.
3. test method: be divided into two echelons, rat is divided into three tested material groups and a control group by every echelon at random, often organizes 20, male and female half and half.
Control group is fed and is raised arm's length basis block material, and tested material group is then fed and raised and mix various dose sample, and dose design is: basic, normal, high dosage component is not 1,2,4g/kgBW (being equivalent to 25 times of people's plan dosage, 50 times, 100 times respectively).Continuous Observation 30 days.
4. observation index and result
4.1 ordinary circumstances are observed:
Observe the performance of animal, behavior, toxic manifestations and death condition every day.Weigh weekly 1 time and food intake dose twice, calculate weekly food utilization and total food utilization.The each treated animal of result grows, activity is all normal, without poisoning manifestations and death, each treated animal is body weight, weekly body weight evolution, weekly food-intake and food utilization weekly weekly, and TBW recruitment, total food-intake and the equal no difference of science of statistics of total foodstuff utilization rate (P>0.05).
4.2 hematological examinations:
Measuring hemoglobin content (Hgb), red blood cell (RBC) and leucocyte (WBC) count, leukocyte differential count (lymph, monokaryon, neutral grain, addicted to acid, basophilic).Experiment latter stage, hematological indices was all in range of normal value, and each treated animal hemoglobin, red blood cell and white blood cell count(WBC), leukocyte differential count be equal no difference of science of statistics (P>0.05) compared with control group.
4.3 Biochemical Indexes:
Measure serum alanine aminotransferase (ALT), aspartate amino transferase (AST), urea nitrogen (BUN), cholesterol (CHO), triglycerides (TG), blood sugar (GLU), total protein (TP), albumin (ALB), creatinine (CRE).The every biochemical indicator of experiment experimental animal in latter stage is all in range of normal value, and each treated animal blood biochemistry index is equal no difference of science of statistics (P>0.05) compared with control group.
4.4 gross examination of skeletal muscle and pathologic diagnosis:
Test cervical dislocation in latter stage puts to death animal, observes each main organs and chest, abdominal cavity general pathology changes.Take out liver, kidney, spleen, the testis of all animals, weigh and calculate organ coefficient.Take out the liver of control group and high dose group animal, kidney, spleen, testis (or ovary), stomach and duodenum, fix with 12% formalin, FFPE, section, HE dyeing, carry out histological examination under light microscopic.Each main organs (heart, liver, spleen, lung, kidney, stomach, intestines etc.) is showed no significant pathological change.
Above-mentioned acute toxicity test and 30 days feeding trial results show that this product belongs to nontoxic level, can long-term taking.
Two, Ergonomy test
1. sample: the sample prepared by formula and technique described in embodiment 3,6.Negative controls is rhodiola root Maca composite sheet, and its formula is gadol extract 48 parts, pueraria root powder 42 parts, microcrystalline cellulose 1 part, cornstarch 8 parts, dolomol 1 part.
2. animal used as test: SPF level healthy NIH kind male mice 240, body weight is 18 ~ 22 grams.
3. experimental technique
Embodiment 3,6 is tested, is divided into two groups.Often group is according to the oral recommendation consumption of people, if the basic, normal, high dosage component of sample is other 100,200,400mg/kgBW (be equivalent to respectively 5,10,20 times that human body recommends consumption), separately establish a negative control group, often organize 10 animals.Take 1,2,4 grams, embodiment 3,6 sample respectively and respectively add pure water to 200ml, mixing, be made into 5,10,20mg/mL strength solution, corresponding dosage treated animal gavage is given by the volume of 0.2mL/10gBW, negative control group (full moringa powder sheet) gives isopyknic pure water, every day gavage once, continuous gavage measures every alleviating physical fatigue functional parameter after 30 days.
4, observation index
4.1 impacts on Mouse Weight
After per os gives the sample 30d of mouse various dose, experiment initial stage, experiment mid-term, the Mouse Weight of experiment embodiment 3,6 sample in latter stage each dosage group and the body weight of experimental session mouse increase and comparing between negative control group, there are no significant for difference (P > 0.05), shows that embodiment 3,6 sample increases the body weight of mouse and have no significant effect.
4.2 impacts on the mice burden swimming time
Table 2: the walking weight load of each group mouse
Note a:P<0.01, b:P > 0.05; C:P<0.05
As seen from Table 2, heavy burden (6%) swimming time of embodiment 3,6 sample each dosage group mouse is all than the prolongation of negative control group, and the difference of high dose group and negative control group has very significant (P<0.01), show that embodiment 3,6 has the effect of the walking weight load extending mouse.
4.3 impacts on the serum urea level after mouse movement
Table 3: the serum urea measurement result after each group mouse movement
Note a:P<0.01, b:P > 0.05; C:P<0.05
As seen from Table 3, the serum urea content of embodiment 3,6 sample each dosage group mouse is all lower than control group, and the difference of high dose group and negative control group has conspicuousness (P<0.05), show that embodiment 3,6 can reduce the generation of tired mice serum urea.
4.4 impacts on the blood lactase acid value after mouse movement
Table 4: blood lactase acid (mg/L) TG-AUC after each group mouse movement
Note a:P<0.01, b:P > 0.05; C:P<0.05
As seen from Table 4,3 time point blood lactase acid TG-AUCs of each dosage of sample are all less than negative control group, and the difference of high dose group and negative control group has very significant P<0.01), show this sample can reduce mouse movement after blood lactase acid TG-AUC.
4.5 functional evaluation results
Experimental result shows, respectively with 100,200, embodiment 3,6 sample of 400mg/kgBW (being equivalent to human body recommended amounts 5,10,20 times respectively) dosage is to the continuous gavage of mouse 30 days, the walking weight load of mouse can be extended, the generation of tired mice serum urea can be reduced, reduce the blood lactase acid TG-AUC after mouse movement, the body weight of mouse is increased and has no significant effect, show that embodiment 3,6 sample has the function of alleviating physical fatigue, than negative controls (rhodiola root Maca composite sheet) good health care effect.
Above embodiment is only for illustration of the present invention, but not limitation of the present invention.Although with reference to embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that, various combination, amendment or equivalent replacement are carried out to technical scheme of the present invention, do not depart from the spirit and scope of technical solution of the present invention, all should be encompassed in the middle of right of the present invention.
Claims (10)
1. a fatigue resistant health food; it is characterized in that; this health food comprises the raw material of following weight portion: gadol extract 15-90 part, taurine 1-40 part, pueraria root powder 10-40 part; glutamine 0-7 part; arginine 0-6 part, zinc gluconate 0-4 part, microcrystalline cellulose 0-5 part; auxiliary material 0-20 part, lubricant 0-2 part.
2. fatigue resistant health food according to claim 1; it is characterized in that; described health food comprises the raw material of following weight portion: gadol extract 25-80 part, taurine 3-30 part, pueraria root powder 15-35 part; glutamine 1-5 part; arginine 1-5 part, zinc gluconate 1-3 part, microcrystalline cellulose 1-4 part; auxiliary material 4-19 part, lubricant 1-2 part.
3. fatigue resistant health food according to claim 1; it is characterized in that; described health food comprises the raw material of following weight portion: gadol extract 30-70 part, taurine 7-26 part, pueraria root powder 20-30 part; glutamine 1-4 part; arginine 1-4 part, zinc gluconate 1-2.5 part, microcrystalline cellulose 1-3 part; auxiliary material 6-15 part, lubricant 1-1.8 part.
4. fatigue resistant health food according to claim 1; it is characterized in that; described health food comprises the raw material of following weight portion: gadol extract 40-55 part, taurine 16-23 part, pueraria root powder 22-28 part; glutamine 1-3 part; arginine 1-3 part, zinc gluconate 1-2.2 part, microcrystalline cellulose 1-2 part; auxiliary material 7-11 part, lubricant 1-1.5 part.
5. fatigue resistant health food according to claim 1; it is characterized in that; described health food comprises the raw material of following weight portion: gadol extract 45-48 part, taurine 18-20 part, pueraria root powder 22-25 part; glutamine 1-2 part; arginase 12-2.5 parts, zinc gluconate 1-2 part, microcrystalline cellulose 1-1.5 part; auxiliary material 7-8 part, lubricant 1-1.2 part.
6. fatigue resistant health food according to claim 1; it is characterized in that; described health food comprises the raw material of following weight portion: gadol extract 48 parts; taurine 18 parts; pueraria root powder 22 parts; glutamine 2 parts, arginase 12 part, zinc gluconate 2 parts, microcrystalline cellulose 1 part, auxiliary material 8 parts, lubricant 1 part.
7. according to the fatigue resistant health food of any one of claim 1-6, it is characterized in that, described auxiliary material is cornstarch.
8. according to the fatigue resistant health food of any one of claim 1-6, it is characterized in that, described lubricant is dolomol.
9. according to the fatigue resistant health food of any one of claim 1-6, it is characterized in that, Determination of Salidroside >=3% of described gadol extract.
10. the preparation method of the fatigue resistant health food of any one of claim 1-9, it is characterized in that, the method comprising the steps of: take raw material according to weight portion, bulk or coarse raw material are pulverized, all raw materials are crossed 80-100 mesh sieve, mix with equal increments hybrid technology according to formula, cross 20-60 mesh sieve, put into mixer to stir, mixing time 15-30 minute, cross 20-40 mesh sieve, put into mixer Homogeneous phase mixing again, mixing time 15-30 minute, after 20-40 mesh sieve, add the ethanol of the volumetric concentration 70-95% accounting for gross weight 5-15%, be uniformly mixed granulation 15-30 minute, cross 10-30 mesh sieve, 60-100 DEG C of oven dry, batch mixing is obtained after the whole grain of 10-30 mesh sieve, add the lubricant of formula ratio, mixing and stirring, be pressed into sheet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510641879.2A CN105211856A (en) | 2015-09-30 | 2015-09-30 | A kind of fatigue resistant health food and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510641879.2A CN105211856A (en) | 2015-09-30 | 2015-09-30 | A kind of fatigue resistant health food and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105211856A true CN105211856A (en) | 2016-01-06 |
Family
ID=54981469
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510641879.2A Pending CN105211856A (en) | 2015-09-30 | 2015-09-30 | A kind of fatigue resistant health food and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105211856A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106108016A (en) * | 2016-06-28 | 2016-11-16 | 广州市赛健生物科技有限公司 | A kind of health food for relieving physical fatigue and preparation method thereof |
| CN106307515A (en) * | 2016-08-29 | 2017-01-11 | 张子亮 | Fatigue resistant food and preparing method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1546087A (en) * | 2003-12-01 | 2004-11-17 | 上海交大昂立股份有限公司 | Heart and brain nourishing products consisted of gadol mainly and its preparation |
| CN1759761A (en) * | 2005-09-30 | 2006-04-19 | 北京康比特威创体育新技术发展有限公司 | Beverage for promoting sportive recovery from fatigue |
| CN103005435A (en) * | 2012-12-13 | 2013-04-03 | 北京康比特体育科技股份有限公司 | Anti-fatigue composition capable of improving speed endurance and preparation containing anti-fatigue composition |
| CN103948039A (en) * | 2014-05-14 | 2014-07-30 | 郭友用 | Health-care food with function of relieving physical fatigue and preparation method of health-care food |
| CN104257717A (en) * | 2014-10-13 | 2015-01-07 | 昆明固康保健品有限公司 | Preparation of high-activity Maca extract as well as compound preparation formula and application of Maca extract |
-
2015
- 2015-09-30 CN CN201510641879.2A patent/CN105211856A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1546087A (en) * | 2003-12-01 | 2004-11-17 | 上海交大昂立股份有限公司 | Heart and brain nourishing products consisted of gadol mainly and its preparation |
| CN1759761A (en) * | 2005-09-30 | 2006-04-19 | 北京康比特威创体育新技术发展有限公司 | Beverage for promoting sportive recovery from fatigue |
| CN103005435A (en) * | 2012-12-13 | 2013-04-03 | 北京康比特体育科技股份有限公司 | Anti-fatigue composition capable of improving speed endurance and preparation containing anti-fatigue composition |
| CN103948039A (en) * | 2014-05-14 | 2014-07-30 | 郭友用 | Health-care food with function of relieving physical fatigue and preparation method of health-care food |
| CN104257717A (en) * | 2014-10-13 | 2015-01-07 | 昆明固康保健品有限公司 | Preparation of high-activity Maca extract as well as compound preparation formula and application of Maca extract |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106108016A (en) * | 2016-06-28 | 2016-11-16 | 广州市赛健生物科技有限公司 | A kind of health food for relieving physical fatigue and preparation method thereof |
| CN106307515A (en) * | 2016-08-29 | 2017-01-11 | 张子亮 | Fatigue resistant food and preparing method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102429066B (en) | Physical strength-enhancing anti-fatigue compound Maca coffee product | |
| CN101810223B (en) | Functional milky tea powder and preparation method thereof | |
| CN102742737B (en) | Selenium-rich total mixed ration for fattening sheep, and production method thereof | |
| CN101991019A (en) | Traditional Chinese medicine chicken feed and production method of silky fowl egg capable of tonifying kidney, strengthening yang and resisting fatigue | |
| CN102845339A (en) | Farming method of selenium-enriched Yellow River carp | |
| CN107114798A (en) | In a kind of generation for loss of weight, eats nutrition bar and preparation method thereof | |
| CN105124154A (en) | River crab feed capable of strengthening immunity | |
| CN106174479A (en) | A kind of geriatric nutrition powder and preparation method thereof | |
| CN102919851B (en) | Health-care food composition for assisting to improve memory and preparation method thereof | |
| CN108703364A (en) | Treating fatty acid metabolism tailored version clinical nutrition formula and preparation method thereof | |
| CN102907663A (en) | Healthcare food composition for relieving physical fatigue and preparation method of healthcare food composition | |
| CN105211856A (en) | A kind of fatigue resistant health food and preparation method thereof | |
| CN105639619A (en) | Energy gel and preparation method thereof | |
| KR100595459B1 (en) | Composition for inhibiting obesity | |
| CN104026568B (en) | A kind of Halth-care composition | |
| CN102885311A (en) | Composite health food composition for alleviating physical fatigue and preparation method thereof | |
| RU2634956C1 (en) | Method for feeding broiler chickens with fodder additive based on betulin-containing birch bark extract | |
| CN100531783C (en) | Health-care food for reducing blood sugar on the assistant role and its preparing process | |
| CN101336723B (en) | Health food for relieving physical fatigue | |
| CN106213034B (en) | It is a kind of improve tool metabolic syndrome Tilapia mossambica health vitamin premix and application | |
| CN102526333A (en) | Composition for regulating blood fat and protecting heart and blood vessels | |
| CN109717330A (en) | Carp feed and preparation method thereof | |
| CN103689607A (en) | Application of wood frog high protein calcium powder in preparation of calcium-supplementing health-care products or drugs | |
| CN1679593A (en) | Composite preparation containing alpha-linolenic acid free acid, soybean phospholipid and vitamin E | |
| CN109157548A (en) | It is a kind of with antifatigue and Yang strengthening function composition and preparation method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160106 |
|
| RJ01 | Rejection of invention patent application after publication |