CN107596435A - A kind of gel of wound repair containing bioactivity glass - Google Patents

A kind of gel of wound repair containing bioactivity glass Download PDF

Info

Publication number
CN107596435A
CN107596435A CN201710784993.XA CN201710784993A CN107596435A CN 107596435 A CN107596435 A CN 107596435A CN 201710784993 A CN201710784993 A CN 201710784993A CN 107596435 A CN107596435 A CN 107596435A
Authority
CN
China
Prior art keywords
gel
base fluid
bioactivity glass
accounts
wound repair
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201710784993.XA
Other languages
Chinese (zh)
Inventor
张宏宇
顾志明
钱伟
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Suzhou Pavilion Medical Technology Development Co Ltd
Original Assignee
Suzhou Pavilion Medical Technology Development Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suzhou Pavilion Medical Technology Development Co Ltd filed Critical Suzhou Pavilion Medical Technology Development Co Ltd
Priority to CN201710784993.XA priority Critical patent/CN107596435A/en
Publication of CN107596435A publication Critical patent/CN107596435A/en
Pending legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Present invention is disclosed a kind of gel of wound repair containing bioactivity glass, it is made up of base fluid, bioactivity glass powder, Silica hydrogel, hyaluronic acid sodium gel, Peppermint essential oil, wherein, base fluid is mixed into by yellow petroleum jelly, atoleine, lanolin, wherein according to mass component ratio, yellow petroleum jelly accounts for the 60 80% of the base fluid, atoleine accounts for the 10 30% of the base fluid, lanolin accounts for the 10% of the base fluid, base fluid accounts for the 75 82% of wound repair gel, and bioactivity glass powder accounts for the 16 23% of wound repair gel:Silica hydrogel accounts for the 0.4 0.6% of wound repair gel, and hyaluronic acid sodium gel accounts for the 0.8 1.3% of wound repair gel:Peppermint essential oil accounts for the 0.3 0.6% of wound repair gel.Beneficial effect of the present invention is:With good wound repairing ability, moreover it is possible to anti-inflammation, the speed of wound healing.

Description

A kind of gel of wound repair containing bioactivity glass
【Technical field】
The invention belongs to medical material tech field, more particularly to a kind of gel of wound repair containing bioactivity glass.
【Background technology】
Bioactivity glass (bioactiveglass, BAG) be one kind body tissue can be repaired, substitute with again Life, there is the material that can make that bonding action is formed between tissue and material.BAG had found in 1969 by Hench, by SiO2, The silicate glass of the bases such as Na2O, CaO and P2O5 composition.The catabolite of bioactivity glass can promote growth because The generation of son, the procreation for promoting cell, the gene expression for strengthening Gegenbaur's cell and the growth of bone tissue.Be so far it is unique both It can be combined with bone tissue bonding, while the bioartificial materials that and can is connected with soft tissue.
Chinese Patent Application No. CN201610170827.6 patents disclosed in 29 days disclose one kind within 06 month 2016 Wound repair gel, wound repair gel is counted in parts by weight to be made up of following component:10~40 parts of bioactive glass powder, 2~10 parts of polyethylene glycol 400,10~25 parts of Silica hydrogel, 5~15 parts of hyaluronic acid sodium gel, 0.1~2 part of acid particles, ice 0.5~5 part of piece, 0.1~0.5 part of absolute ethyl alcohol.Described bioactive glass powder consists of the following composition:SiO2: 45.0% (± 1%), CaO:24.5% (± 1%), Na2O:24.5% (± 1%), P2O5:6.0% (± 1%).The biology is living Property glass wound repair gel is to chronic large area surface of a wound such as burn, bedsore, diabetes, contusion and all kinds of skin surface ulcer Treatment there is the effect of notable, while the gel have prevent adhesion, antibacterial, moisturizing, the special efficacy such as growth for suppressing scar.
On above-mentioned technical proposal is generally based on, the research of correlation is made, wound repair speed is improved so as to reach Effect.
A kind of it is therefore proposed that gel of wound repair containing bioactivity glass that can improve wound repair speed.
【The content of the invention】
It is a primary object of the present invention to provide a kind of surface of a wound containing bioactivity glass that can improve wound repair speed Repair gel.
The present invention is achieved through the following technical solutions above-mentioned purpose:A kind of gel of wound repair containing bioactivity glass, its It is characterised by:It is made up of base fluid, bioactivity glass powder, Silica hydrogel, hyaluronic acid sodium gel, Peppermint essential oil, wherein, base fluid It is mixed into by yellow petroleum jelly, atoleine, lanolin, wherein according to mass component ratio, yellow petroleum jelly accounts for the 60- of the base fluid 80%, atoleine accounts for the 10-30% of the base fluid, and lanolin accounts for the 10% of the base fluid, and base fluid accounts for the 75- of wound repair gel 82%, bioactivity glass powder accounts for the 16-23% of wound repair gel:Silica hydrogel accounts for the 0.4-0.6% of wound repair gel, Hyaluronic acid sodium gel accounts for the 0.8-1.3% of wound repair gel:Peppermint essential oil accounts for the 0.3-0.6% of wound repair gel.
The base fluid is according to yellow petroleum jelly:Atoleine:Lanolin=7:2:1 prepares, wherein, base fluid:Bioactivity glass Glass powder:Silica hydrogel:Hyaluronic acid sodium gel:Peppermint essential oil is 80:18:0.5:1:0.5.
The base fluid is according to yellow petroleum jelly:Atoleine:Lanolin=6:3:1 prepares, wherein, base fluid:Bioactivity glass Glass powder:Silica hydrogel:Hyaluronic acid sodium gel:Peppermint essential oil is 75:23:0.4:1.3:0.3.
The base fluid is according to yellow petroleum jelly:Atoleine:Lanolin=8:1:1 prepares, wherein, base fluid:Bioactivity glass Glass powder:Silica hydrogel:Hyaluronic acid sodium gel:Peppermint essential oil is 82:16:0.6:0.8:0.6.
The molecular weight of hyaluronic acid sodium gel is 10000.
Compared with prior art, a kind of beneficial effect of the gel of wound repair containing bioactivity glass of the present invention is:Tool There is good wound repairing ability, moreover it is possible to anti-inflammation, the speed of wound healing.
【Embodiment】
The present invention is a kind of gel of wound repair containing bioactivity glass, is coagulated by base fluid, bioactivity glass powder, silicon Glue, hyaluronic acid sodium gel, Peppermint essential oil composition, wherein, base fluid is mixed into by yellow petroleum jelly, atoleine, lanolin, wherein According to mass component ratio, yellow petroleum jelly accounts for the 60-80% of the base fluid, and atoleine accounts for the 10-30% of the base fluid, and lanolin accounts for this The 10% of base fluid, and repair in gel, base fluid accounts for 75-82%, and bioactivity glass powder accounts for 16-23%:Silica hydrogel accounts for 0.4- 0.6%, hyaluronic acid sodium gel accounts for 0.8-1.3%:Peppermint essential oil accounts for 0.3-0.6%.
Technical scheme is described further with reference to embodiment.
Embodiment 1
First, yellow petroleum jelly is heated, makes its thawing, example in mass ratio is mixed in atoleine, is added lanolin, is pressed Base fluid is formed according to mass ratio, base fluid is according to yellow petroleum jelly:Atoleine:Lanolin=7:2:1 is prepared.It is and fully mixed Close, the base fluid of Extraction and determination.
Secondly, the bioactivity glass powder into base fluid, according to mass component ratio, base fluid:Bioactivity glass powder=50: 9, under the conditions of 20~35 DEG C, stir to bioactivity glass powder and be completely dissolved;
Silica hydrogel is added into mixed liquor again, according to mass component ratio, base fluid:Silica hydrogel=160:1, in 20~35 DEG C of bars Under part, it is sufficiently stirred to form glue,
The hyaluronic acid sodium gel of 10000 molecular weight is added, according to mass component ratio, base fluid:Hyaluronic acid sodium gel =80:1, under the conditions of 20~35 DEG C, it is sufficiently stirred to form glue;
Then Peppermint essential oil is added according to mass component ratio, base fluid:Peppermint essential oil=160:1, mixing is stirred, is formed Repair gel.
Therefore, according to mass component ratio, base fluid:Bioactivity glass powder:Silica hydrogel:Hyaluronic acid sodium gel:Peppermint Essential oil is 80:18:0.5:1:0.5.
Silica hydrogel is at least one of methyl vinyl silicon oil, methyl-silicone oil, ethyl silicon oil.Described Sodium Hyaluronate Gel is prepared by following methods:Hyal powder first is infiltrated with appropriate glycerine, after being uniformly dispersed, is added a small amount of Water dissolves;Wherein the mass percent of Sodium Hyaluronate is 0.5%~1%, and the mass percent of glycerine and distilled water is 7-8:2-3。
Embodiment 2
First, yellow petroleum jelly is heated, makes its thawing, example in mass ratio is mixed in atoleine, is added lanolin, is pressed Base fluid is formed according to mass ratio, base fluid is according to yellow petroleum jelly:Atoleine:Lanolin=6:3:1 is prepared.It is and fully mixed Close, the base fluid of Extraction and determination.
In the way of embodiment 1, according to mass component ratio, base fluid:Bioactivity glass powder:Silica hydrogel:Hyalomitome Sour sodium gel:Peppermint essential oil is 75:23:0.4:1.3:0.3.
Secondly, the bioactivity glass powder into base fluid, under the conditions of 20~35 DEG C, stir complete to bioactivity glass powder Fully dissolved;
Silica hydrogel is added into mixed liquor again, under the conditions of 20~35 DEG C, is sufficiently stirred to form glue,
The hyaluronic acid sodium gel of 10000 molecular weight is added, under the conditions of 20~35 DEG C, is sufficiently stirred to form glue;
Then Peppermint essential oil is added, is stirred mixing, is formed and repairs gel.
Silica hydrogel is at least one of methyl vinyl silicon oil, methyl-silicone oil, ethyl silicon oil.Described Sodium Hyaluronate Gel is prepared by following methods:Hyal powder first is infiltrated with appropriate glycerine, after being uniformly dispersed, is added a small amount of Water dissolves;Wherein the mass percent of Sodium Hyaluronate is 0.5%~1%, and the mass percent of glycerine and distilled water is 7-8:2-3。
Embodiment 3:
First, yellow petroleum jelly is heated, makes its thawing, example in mass ratio is mixed in atoleine, is added lanolin, is pressed Base fluid is formed according to mass ratio, base fluid is according to yellow petroleum jelly:Atoleine:Lanolin=8:1:1 is prepared.It is and fully mixed Close, the base fluid of Extraction and determination.
In the way of embodiment 1, according to mass component ratio, base fluid:Bioactivity glass powder:Silica hydrogel:Hyalomitome Sour sodium gel:Peppermint essential oil is 82:16:0.6:0.8:0.6.
Secondly, the bioactivity glass powder into base fluid, under the conditions of 20~35 DEG C, stir complete to bioactivity glass powder Fully dissolved;
Silica hydrogel is added into mixed liquor again, under the conditions of 20~35 DEG C, is sufficiently stirred to form glue,
The hyaluronic acid sodium gel of 10000 molecular weight is added, under the conditions of 20~35 DEG C, is sufficiently stirred to form glue;
Then Peppermint essential oil is added, is stirred mixing, is formed and repairs gel.
Silica hydrogel is at least one of methyl vinyl silicon oil, methyl-silicone oil, ethyl silicon oil.Described Sodium Hyaluronate Gel is prepared by following methods:Hyal powder first is infiltrated with appropriate glycerine, after being uniformly dispersed, is added a small amount of Water dissolves;Wherein the mass percent of Sodium Hyaluronate is 0.5%~1%, and the mass percent of glycerine and distilled water is 7-8:2-3。
Embodiment 4
First, yellow petroleum jelly is heated, makes its thawing, example in mass ratio is mixed in atoleine, is added lanolin, is pressed Base fluid is formed according to mass ratio, base fluid is according to yellow petroleum jelly:Atoleine:Lanolin=7:2:1 is prepared.It is and fully mixed Close, the base fluid of Extraction and determination.
In the way of embodiment 1, according to mass component ratio, base fluid:Bioactivity glass powder:Silica hydrogel:Hyalomitome Sour sodium gel:Peppermint essential oil is 75:23:0.4:1.3:0.3.
Secondly, the bioactivity glass powder into base fluid, under the conditions of 20~35 DEG C, stir complete to bioactivity glass powder Fully dissolved;
Silica hydrogel is added into mixed liquor again, under the conditions of 20~35 DEG C, is sufficiently stirred to form glue,
The hyaluronic acid sodium gel of 10000 molecular weight is added, under the conditions of 20~35 DEG C, is sufficiently stirred to form glue;
Then Peppermint essential oil is added, is stirred mixing, is formed and repairs gel.
Embodiment 5
First, yellow petroleum jelly is heated, makes its thawing, example in mass ratio is mixed in atoleine, is added lanolin, is pressed Base fluid is formed according to mass ratio, base fluid is according to yellow petroleum jelly:Atoleine:Lanolin=7:2:1 is prepared.It is and fully mixed Close, the base fluid of Extraction and determination.
In the way of embodiment 1, according to mass component ratio, base fluid:Bioactivity glass powder:Silica hydrogel:Hyalomitome Sour sodium gel:Peppermint essential oil is 82:16:0.6:0.8:0.6.
Secondly, the bioactivity glass powder into base fluid, under the conditions of 20~35 DEG C, stir complete to bioactivity glass powder Fully dissolved;
Silica hydrogel is added into mixed liquor again, under the conditions of 20~35 DEG C, is sufficiently stirred to form glue,
The hyaluronic acid sodium gel of 10000 molecular weight is added, under the conditions of 20~35 DEG C, is sufficiently stirred to form glue;
Then Peppermint essential oil is added, is stirred mixing, is formed and repairs gel.
Embodiment 6
First, yellow petroleum jelly is heated, makes its thawing, example in mass ratio is mixed in atoleine, is added lanolin, is pressed Base fluid is formed according to mass ratio, base fluid is according to yellow petroleum jelly:Atoleine:Lanolin=6:3:1 is prepared.It is and fully mixed Close, the base fluid of Extraction and determination.
In the way of embodiment 1, according to mass component ratio, base fluid:Bioactivity glass powder:Silica hydrogel:Hyalomitome Sour sodium gel:Peppermint essential oil is 80:18:0.5:1:0.5.
Secondly, the bioactivity glass powder into base fluid, under the conditions of 20~35 DEG C, stir complete to bioactivity glass powder Fully dissolved;
Silica hydrogel is added into mixed liquor again, under the conditions of 20~35 DEG C, is sufficiently stirred to form glue,
The hyaluronic acid sodium gel of 10000 molecular weight is added, under the conditions of 20~35 DEG C, is sufficiently stirred to form glue;
Then Peppermint essential oil is added, is stirred mixing, is formed and repairs gel.
Embodiment 7
First, yellow petroleum jelly is heated, makes its thawing, example in mass ratio is mixed in atoleine, is added lanolin, is pressed Base fluid is formed according to mass ratio, base fluid is according to yellow petroleum jelly:Atoleine:Lanolin=6:3:1 is prepared.It is and fully mixed Close, the base fluid of Extraction and determination.
In the way of embodiment 1, according to mass component ratio, base fluid:Bioactivity glass powder:Silica hydrogel:Hyalomitome Sour sodium gel:Peppermint essential oil is 82:16:0.6:0.8:0.6.
Secondly, the bioactivity glass powder into base fluid, under the conditions of 20~35 DEG C, stir complete to bioactivity glass powder Fully dissolved;
Silica hydrogel is added into mixed liquor again, under the conditions of 20~35 DEG C, is sufficiently stirred to form glue,
The hyaluronic acid sodium gel of 10000 molecular weight is added, under the conditions of 20~35 DEG C, is sufficiently stirred to form glue;
Then Peppermint essential oil is added, is stirred mixing, is formed and repairs gel.
Embodiment 8
First, yellow petroleum jelly is heated, makes its thawing, example in mass ratio is mixed in atoleine, is added lanolin, is pressed Base fluid is formed according to mass ratio, base fluid is according to yellow petroleum jelly:Atoleine:Lanolin=8:1:1 is prepared.It is and fully mixed Close, the base fluid of Extraction and determination.
In the way of embodiment 1, according to mass component ratio, base fluid:Bioactivity glass powder:Silica hydrogel:Hyalomitome Sour sodium gel:Peppermint essential oil is 80:18:0.5:1:0.5..
Secondly, the bioactivity glass powder into base fluid, under the conditions of 20~35 DEG C, stir complete to bioactivity glass powder Fully dissolved;
Silica hydrogel is added into mixed liquor again, under the conditions of 20~35 DEG C, is sufficiently stirred to form glue,
The hyaluronic acid sodium gel of 10000 molecular weight is added, under the conditions of 20~35 DEG C, is sufficiently stirred to form glue;
Then Peppermint essential oil is added, is stirred mixing, is formed and repairs gel.
Embodiment 9
First, yellow petroleum jelly is heated, makes its thawing, example in mass ratio is mixed in atoleine, is added lanolin, is pressed Base fluid is formed according to mass ratio, base fluid is according to yellow petroleum jelly:Atoleine:Lanolin=8:1:1 is prepared.It is and fully mixed Close, the base fluid of Extraction and determination.
In the way of embodiment 1, according to mass component ratio, base fluid:Bioactivity glass powder:Silica hydrogel:Hyalomitome Sour sodium gel:Peppermint essential oil is 75:23:0.4:1.3:0.3.
Secondly, the bioactivity glass powder into base fluid, under the conditions of 20~35 DEG C, stir complete to bioactivity glass powder Fully dissolved;
Silica hydrogel is added into mixed liquor again, under the conditions of 20~35 DEG C, is sufficiently stirred to form glue,
The hyaluronic acid sodium gel of 10000 molecular weight is added, under the conditions of 20~35 DEG C, is sufficiently stirred to form glue;
Then Peppermint essential oil is added, is stirred mixing, is formed and repairs gel.
The hyaluronic acid of each embodiment is 10000 low molecule amount in the present invention,
Bioactivity glass aperture is in 50 microns.
Verified by zoopery, the product not only has good wound repairing ability, moreover it is possible to anti-inflammation, improve wound The speed of face healing.
According to existing experimental method, the concrete operations of zoopery are as follows:It is left in 200g from 60 SD rats, body weight The right side, 8 week old, each 30 of male and female, divide 3 groups, separate cage.24h carries out back depilation processing, depilation to experimental animal before experiment Routine feeding afterwards;Start to test, all experiment mouses are carried out with intraperitoneal injection 300mg/kg 10% chloraldurate solution Anesthesia, normal sterile processing;In carrying out mark with a diameter of 1.5cm circular hole at 1cm by SD rat back backbones both sides, then Epidermis, corium and subcutaneous connective tissue are removed with scalpel, per side 2,5 wounds of every mouse, 5 wounds are applied respectively The gel of embodiment 1-3 synthesis provided by the invention compares the most with existing gel, is finally wrapped up respectively with sterile gauze, often Day dosing once, observes the healing state of the surface of a wound.
In addition, being smeared respectively a variety of gels by human body, subject is provided to gel use feeling, by as above The result:
Project Healing time (my god) Subject assessment
Embodiment 1 5 There is refrigerant sense, without any excitement
Embodiment 2 5.5 There is refrigerant sense, without any excitement
Embodiment 3 5.5 There is refrigerant sense, without any excitement
Embodiment 4 5 There is refrigerant sense, without any excitement
Embodiment 5 5 There is refrigerant sense, without any excitement
Embodiment 6 5.5 There is refrigerant sense, without any excitement
Embodiment 7 5.5 There is refrigerant sense, without any excitement
Embodiment 8 5.5 There is refrigerant sense, without any excitement
Embodiment 9 5.5 There is refrigerant sense, without any excitement
Control group 1 6 Without refrigerant sense, without any excitement
Control group 2 6 Without refrigerant sense, a little excitement
Above-described is only some embodiments of the present invention.For the person of ordinary skill of the art, not On the premise of departing from the invention design, various modifications and improvements can be made, these belong to the protection model of the present invention Enclose.

Claims (5)

  1. A kind of 1. gel of wound repair containing bioactivity glass, it is characterised in that:Coagulated by base fluid, bioactivity glass powder, silicon Glue, hyaluronic acid sodium gel, Peppermint essential oil composition, wherein, base fluid is mixed into by yellow petroleum jelly, atoleine, lanolin, wherein According to mass component ratio, yellow petroleum jelly accounts for the 60-80% of the base fluid, and atoleine accounts for the 10-30% of the base fluid, and lanolin accounts for this The 10% of base fluid, base fluid account for the 75-82% of wound repair gel, and bioactivity glass powder accounts for the 16- of wound repair gel 23%:Silica hydrogel accounts for the 0.4-0.6% of wound repair gel, and hyaluronic acid sodium gel accounts for the 0.8-1.3% of wound repair gel: Peppermint essential oil accounts for the 0.3-0.6% of wound repair gel.
  2. 2. the gel of wound repair containing bioactivity glass as claimed in claim 1, it is characterised in that:The base fluid is according to yellow all Intellectual circle:Atoleine:Lanolin=7:2:1 prepares, wherein, base fluid:Bioactivity glass powder:Silica hydrogel:Sodium Hyaluronate Gel:Peppermint essential oil is 80:18:0.5:1:0.5.
  3. 3. the gel of wound repair containing bioactivity glass as claimed in claim 1, it is characterised in that:The base fluid is according to yellow all Intellectual circle:Atoleine:Lanolin=6:3:1 prepares, wherein, base fluid:Bioactivity glass powder:Silica hydrogel:Sodium Hyaluronate Gel:Peppermint essential oil is 75:23:0.4:1.3:0.3.
  4. 4. the gel of wound repair containing bioactivity glass as claimed in claim 1, it is characterised in that:The base fluid is according to yellow all Intellectual circle:Atoleine:Lanolin=8:1:1 prepares, wherein, base fluid:Bioactivity glass powder:Silica hydrogel:Sodium Hyaluronate Gel:Peppermint essential oil is 82:16:0.6:0.8:0.6.
  5. 5. the gel of wound repair containing bioactivity glass as claimed in claim 1, it is characterised in that:Hyaluronic acid sodium gel Molecular weight is 10000.
CN201710784993.XA 2017-09-04 2017-09-04 A kind of gel of wound repair containing bioactivity glass Pending CN107596435A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201710784993.XA CN107596435A (en) 2017-09-04 2017-09-04 A kind of gel of wound repair containing bioactivity glass

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201710784993.XA CN107596435A (en) 2017-09-04 2017-09-04 A kind of gel of wound repair containing bioactivity glass

Publications (1)

Publication Number Publication Date
CN107596435A true CN107596435A (en) 2018-01-19

Family

ID=61057343

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201710784993.XA Pending CN107596435A (en) 2017-09-04 2017-09-04 A kind of gel of wound repair containing bioactivity glass

Country Status (1)

Country Link
CN (1) CN107596435A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110368517A (en) * 2019-07-26 2019-10-25 深圳阳光环球玻璃有限公司 A kind of wound hemostasis reparation bioactivity glass medical material
CN112057681A (en) * 2020-10-23 2020-12-11 温州医科大学慈溪生物医药研究院 Composition containing bioglass ceramics and application thereof in scar repair
CN114558168A (en) * 2022-03-25 2022-05-31 白绍静 Active induced wound repair gel and preparation method and manufacturing equipment thereof
CN116328017A (en) * 2023-04-13 2023-06-27 江苏汇锦然医疗器械有限公司 Highly antibacterial vertical absorption alginate dressing and preparation method thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1252995A (en) * 1998-11-06 2000-05-17 陈军 Burn cream
WO2007072065A3 (en) * 2005-12-23 2007-10-04 Advanced Bio Technologies Inc Silicone composition
CN104983754A (en) * 2015-06-16 2015-10-21 吉林万通药业集团郑州万通复升药业股份有限公司 Callus ointment and preparing method thereof
CN104984384A (en) * 2015-07-27 2015-10-21 南阳市汇博生物技术有限公司 Medical antibacterial dressing and preparation method thereof
CN105709271A (en) * 2016-03-24 2016-06-29 广东泰宝医疗科技股份有限公司 Glass wound repair gel with biological activity and preparation method thereof
CN105963771A (en) * 2016-06-29 2016-09-28 广东泰宝医疗科技股份有限公司 Medical dressing with bioactive components and method for preparing medical dressing

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1252995A (en) * 1998-11-06 2000-05-17 陈军 Burn cream
WO2007072065A3 (en) * 2005-12-23 2007-10-04 Advanced Bio Technologies Inc Silicone composition
CN104983754A (en) * 2015-06-16 2015-10-21 吉林万通药业集团郑州万通复升药业股份有限公司 Callus ointment and preparing method thereof
CN104984384A (en) * 2015-07-27 2015-10-21 南阳市汇博生物技术有限公司 Medical antibacterial dressing and preparation method thereof
CN105709271A (en) * 2016-03-24 2016-06-29 广东泰宝医疗科技股份有限公司 Glass wound repair gel with biological activity and preparation method thereof
CN105963771A (en) * 2016-06-29 2016-09-28 广东泰宝医疗科技股份有限公司 Medical dressing with bioactive components and method for preparing medical dressing

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110368517A (en) * 2019-07-26 2019-10-25 深圳阳光环球玻璃有限公司 A kind of wound hemostasis reparation bioactivity glass medical material
CN112057681A (en) * 2020-10-23 2020-12-11 温州医科大学慈溪生物医药研究院 Composition containing bioglass ceramics and application thereof in scar repair
CN114558168A (en) * 2022-03-25 2022-05-31 白绍静 Active induced wound repair gel and preparation method and manufacturing equipment thereof
CN116328017A (en) * 2023-04-13 2023-06-27 江苏汇锦然医疗器械有限公司 Highly antibacterial vertical absorption alginate dressing and preparation method thereof

Similar Documents

Publication Publication Date Title
CN107596435A (en) A kind of gel of wound repair containing bioactivity glass
CN104587518A (en) Hyaluronic acid dressing and preparation method thereof
CN105194719B (en) A kind of facial wound repairs dressing, application and preparation method thereof
CN108210887A (en) A kind of Medical cold application and preparation method thereof
CN106606798A (en) Medical hyaluronic acid bioremediation plaster and preparation method thereof
CN114191597B (en) Liquid dressing for repairing skin wound surface and preparation method and application thereof
CN101780031B (en) Induced gel used for repairing skin wound surfaces or cervical mucosa
CN103751833B (en) Medical antibacterial wound dressing and preparation method thereof
CN105963771B (en) A kind of medical dressing and preparation method thereof containing bioactive ingredients
CN110169948A (en) A kind of canker sore of the material containing bioactive minerals repairs gel and preparation method thereof
CN107007874A (en) A kind of silicon substrate wound repair aqueous gel and preparation method thereof
CN103083712A (en) Stem cells or other bioactive substances doped surgical dressing
CN105013001A (en) Medical biological hydrogel function dressing for gynecology and preparation method of dressing
CN104382843B (en) A kind of skin repair gel
CN106794195A (en) Method and composition for strengthening and extending the cosmetic outcome of No operation skin intervention
CN109010124A (en) A kind of ocean essence gynaecology bacteriostatic gel and preparation method thereof
WO2007033591A1 (en) Active prosthetic material for wounds
CN101596310A (en) A kind of artificial substrate membrane emulsifying paste that is used for wound repair
CN114533654B (en) Low-molecular chondroitin sulfate composite hydrogel and preparation method and application thereof
CN107551090A (en) One kind, which is nourished, repairs gel
Zhu et al. Effectiveness of nano bioactive glass fiber loaded with platelet-rich plasma on thermal wound healing process in rats
CN104225577A (en) Double-treatment-course composite cell growth factor hydrogels as well as preparation methods and applications
CN108079013A (en) A kind of preparation method and application for relieving pain bioactivity glass powder
CN107510704A (en) A kind of antiallergy burn and scald paste containing bio-vitric
CN103191163B (en) Skin wound repairing pharmaceutical composition

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20180119

RJ01 Rejection of invention patent application after publication