CN107595790B - 口腔崩解片 - Google Patents

口腔崩解片 Download PDF

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Publication number
CN107595790B
CN107595790B CN201710899077.0A CN201710899077A CN107595790B CN 107595790 B CN107595790 B CN 107595790B CN 201710899077 A CN201710899077 A CN 201710899077A CN 107595790 B CN107595790 B CN 107595790B
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China
Prior art keywords
tablet
tablets
ticagrelor
blister
weight
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Application number
CN201710899077.0A
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English (en)
Chinese (zh)
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CN107595790A (zh
Inventor
F.A.K.M.阿尔赫斯本
L.H.C.格拉德
J.M.C.哈尔斯坦
A.J.莫伊尔
M.P.汤普森
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AstraZeneca AB
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AstraZeneca AB
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Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of CN107595790A publication Critical patent/CN107595790A/zh
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/03Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
    • A61J1/035Blister-type containers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/10Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2009Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • A61K9/2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2027Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2095Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/325Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil
    • B65D75/327Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil and forming several compartments

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Physiology (AREA)
  • Mechanical Engineering (AREA)
  • Composite Materials (AREA)
  • Nutrition Science (AREA)
  • Zoology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201710899077.0A 2016-04-21 2017-04-20 口腔崩解片 Active CN107595790B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662325584P 2016-04-21 2016-04-21
US62/325584 2016-04-21
CN201780000516.8A CN107530288B (zh) 2016-04-21 2017-04-20 口腔崩解片

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201780000516.8A Division CN107530288B (zh) 2016-04-21 2017-04-20 口腔崩解片

Publications (2)

Publication Number Publication Date
CN107595790A CN107595790A (zh) 2018-01-19
CN107595790B true CN107595790B (zh) 2021-01-12

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ID=58640851

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CN201710899077.0A Active CN107595790B (zh) 2016-04-21 2017-04-20 口腔崩解片
CN201780000516.8A Active CN107530288B (zh) 2016-04-21 2017-04-20 口腔崩解片
CN201710898954.2A Active CN107595789B (zh) 2016-04-21 2017-04-20 口腔崩解片

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CN201710898954.2A Active CN107595789B (zh) 2016-04-21 2017-04-20 口腔崩解片

Country Status (26)

Country Link
US (1) US10729655B2 (enExample)
EP (2) EP3445338B1 (enExample)
JP (2) JP6960941B2 (enExample)
KR (2) KR102488486B1 (enExample)
CN (3) CN107595790B (enExample)
AU (2) AU2017253367B2 (enExample)
BR (1) BR112018071440A2 (enExample)
CO (1) CO2018012431A2 (enExample)
DK (1) DK3445338T3 (enExample)
EA (1) EA201892150A1 (enExample)
ES (1) ES3014055T3 (enExample)
FI (1) FI3445338T3 (enExample)
HR (1) HRP20250204T1 (enExample)
HU (1) HUE070095T2 (enExample)
IL (1) IL262312B (enExample)
LT (1) LT3445338T (enExample)
MA (1) MA44720B1 (enExample)
PE (1) PE20190372A1 (enExample)
PH (1) PH12018502226A1 (enExample)
PL (1) PL3445338T3 (enExample)
PT (1) PT3445338T (enExample)
RS (1) RS66536B1 (enExample)
SG (2) SG10202107682QA (enExample)
SI (1) SI3445338T1 (enExample)
SM (1) SMT202500081T1 (enExample)
WO (1) WO2017182589A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111450067A (zh) * 2019-01-18 2020-07-28 北京万全德众医药生物技术有限公司 一种替格瑞洛分散片及其制备方法
CN109700773B (zh) * 2019-03-01 2021-03-16 石药集团中奇制药技术(石家庄)有限公司 一种替格瑞洛制剂组合物及其制备方法
CA3098818A1 (en) 2020-08-19 2022-02-19 Astrazeneca Ab Combination treatment
CN114712317A (zh) * 2021-01-04 2022-07-08 弘和制药有限公司 一种替格瑞洛药物组合物及其制备方法和其应用
US20220387328A1 (en) 2021-06-04 2022-12-08 Glaxosmithkline Consumer Healthcare Holdings (Us) Llc Dosage form for nicotine replacement therapy
CN118265521A (zh) * 2021-10-04 2024-06-28 纽瑞姆制药(1991)有限公司 用于治疗患有孤独症谱系障碍的受试者的方法和产品
WO2024089196A1 (en) 2022-10-28 2024-05-02 Astrazeneca Ab Recombinant apyrase protein for use in the treatment of an ischemic event at a dose of 40-240 mg
CN116370423B (zh) * 2023-02-28 2024-11-12 天津力生制药股份有限公司 一种替格瑞洛口腔崩解片及其制备方法

Citations (3)

* Cited by examiner, † Cited by third party
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CN2717851Y (zh) * 2004-05-14 2005-08-17 重庆康刻尔制药有限公司 一种药品包装板
CN101505754A (zh) * 2006-08-21 2009-08-12 阿斯利康(瑞典)有限公司 包括三唑并[4,5-d]嘧啶衍生物的适于口服给药的组合物
CN102058889A (zh) * 2010-11-05 2011-05-18 王定豪 包含抗凝血类药物的分散片及其应用

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GB516834A (en) * 1937-12-23 1940-01-12 Charles Alexandre Nicolle Improvements in or relating to packaging
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TWI229674B (en) 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
GB0013407D0 (en) * 2000-06-02 2000-07-26 Astrazeneca Ab Forms of a chemical compound
KR20060079257A (ko) * 2001-05-10 2006-07-05 아스텔라스세이야쿠 가부시키가이샤 구강내 신속 붕괴성 정제 및 이의 제조방법
US7390503B1 (en) 2003-08-22 2008-06-24 Barr Laboratories, Inc. Ondansetron orally disintegrating tablets
FR2968992B1 (fr) 2010-12-16 2013-02-08 Sanofi Aventis Comprime pharmaceutique orodispersible a base de zolpidem
US20130160408A1 (en) * 2011-12-22 2013-06-27 Gregor N. Neff Blister Pack and Method
JP5956475B2 (ja) 2012-02-03 2016-07-27 旭化成株式会社 苦味マスク顆粒含有口腔内崩壊錠
CZ2012705A3 (cs) * 2012-10-16 2014-04-23 Zentiva, K.S. Pevná orální farmaceutická formulace obsahující ticagrelor
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CN104650091B (zh) * 2014-01-24 2016-10-05 福州乾正药业有限公司 替格瑞洛的微粉化及其晶型,以及制备方法和药物应用
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Publication number Priority date Publication date Assignee Title
CN2717851Y (zh) * 2004-05-14 2005-08-17 重庆康刻尔制药有限公司 一种药品包装板
CN101505754A (zh) * 2006-08-21 2009-08-12 阿斯利康(瑞典)有限公司 包括三唑并[4,5-d]嘧啶衍生物的适于口服给药的组合物
CN102058889A (zh) * 2010-11-05 2011-05-18 王定豪 包含抗凝血类药物的分散片及其应用

Also Published As

Publication number Publication date
SG10202107682QA (en) 2021-08-30
HRP20250204T1 (hr) 2025-04-11
CO2018012431A2 (es) 2018-11-30
WO2017182589A9 (en) 2018-04-19
BR112018071440A2 (pt) 2019-02-05
CN107530288A (zh) 2018-01-02
JP2019516674A (ja) 2019-06-20
HK1249732A1 (zh) 2018-11-09
DK3445338T3 (da) 2025-02-10
RS66536B1 (sr) 2025-03-31
JP2022009050A (ja) 2022-01-14
EP3445338A1 (en) 2019-02-27
IL262312A (en) 2018-11-29
CN107530288B (zh) 2022-01-25
JP7254871B2 (ja) 2023-04-10
JP6960941B2 (ja) 2021-11-05
AU2020201930B2 (en) 2020-10-29
LT3445338T (lt) 2025-02-25
WO2017182589A1 (en) 2017-10-26
EP4417537A2 (en) 2024-08-21
AU2017253367B2 (en) 2020-04-16
CN107595790A (zh) 2018-01-19
US20190117577A1 (en) 2019-04-25
PL3445338T3 (pl) 2025-03-31
EP3445338B1 (en) 2024-11-27
KR102488486B1 (ko) 2023-01-12
KR102392347B1 (ko) 2022-05-02
MA44720B1 (fr) 2025-02-28
AU2017253367A1 (en) 2018-11-08
MA44720A (fr) 2019-02-27
SI3445338T1 (sl) 2025-03-31
EA201892150A1 (ru) 2019-05-31
CN107595789A (zh) 2018-01-19
PE20190372A1 (es) 2019-03-08
US10729655B2 (en) 2020-08-04
AU2020201930A1 (en) 2020-04-09
FI3445338T3 (fi) 2025-01-29
EP4417537A3 (en) 2024-12-04
HK1248562A1 (zh) 2018-10-19
SMT202500081T1 (it) 2025-03-12
CN107595789B (zh) 2021-01-15
PH12018502226A1 (en) 2019-07-29
SG11201808996SA (en) 2018-11-29
IL262312B (en) 2022-08-01
KR20180132147A (ko) 2018-12-11
KR20220054907A (ko) 2022-05-03
HUE070095T2 (hu) 2025-05-28
PT3445338T (pt) 2025-03-03
ES3014055T3 (en) 2025-04-16

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