CN107586716A - A kind of biology, the electromagnetic shaker of chemical substance separation and concentration - Google Patents
A kind of biology, the electromagnetic shaker of chemical substance separation and concentration Download PDFInfo
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- CN107586716A CN107586716A CN201710961516.6A CN201710961516A CN107586716A CN 107586716 A CN107586716 A CN 107586716A CN 201710961516 A CN201710961516 A CN 201710961516A CN 107586716 A CN107586716 A CN 107586716A
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- concussion
- disk body
- sample pans
- disk
- lifting
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Abstract
A kind of biology, the electromagnetic shaker of chemical substance separation and concentration, including pedestal, set of sample pans, disk elevating mechanism are provided with the pedestal, heating arrangements, mechanism is shaken and is mounted with the control module of associated control software；Disk elevating mechanism includes being used for the disk body for producing magnetic field and the lifting assembly for driving disk body elevating movement, when disk body rises to certain position, set of sample pans enters in magnetic field range, and when disk body drops to certain position, set of sample pans leaves magnetic field range；Heating arrangements include being arranged at the heater for having heating function on set of sample pans；Shaking mechanism includes concussion component, the set of sample pans concussion of concussion Component driver；Disk elevating mechanism and/or concussion mechanism are arranged at below set of sample pans.The present invention can guarantee that the combination of nucleic acid and magnetic bead by the way that heating function, concussion function and magnetically attractive function are integrated in into one；Reduce the chance of equipment error, the effective accuracy for ensureing experimental result.
Description
Technical field
The present invention relates to one kind to shake separator, more particularly to a kind of biology, the electromagnetic shaker of chemical substance separation and concentration.
Background technology
Seperated nuclear acid, albumen or cell are frequently necessary among the research and production of molecular biology, and Beads enrichment is
One of the most frequently used separation method, the experimentation of Beads enrichment are related to heating concussion and magnetically attractive, existing automatic fluid work
In standing, this process mainly is completed by way of simulating and moving disk manually, such as：Reaction system is carried with gripper crawl
Microwell plate, microwell plate is moved in and out into magnetic field, but this mode has the disadvantage that：(1) experimentation is extended, easily led
Nucleic acid is caused to be come off from magnetic bead；(2) increasing the chance of equipment error, (such as microwell plate falls from gripper in transfer process
Fall), influence experimental result；(3) need to occupy more disk positions in the card of liquor removing workstation.
Therefore, it is necessary to traditional structure is further improved.
The content of the invention
It is an object of the invention to provide a kind of biology for integrating heating, concussion with magnetically attractive function, chemical substance point
From the electromagnetic shaker of enrichment；Each function is integrated in an equipment, the transfer back and forth of sample is avoided, improves conventional efficient, be effective
Prevent nucleic acid from being come off from magnetic bead, eliminate sample gripping work, reduce error probability, ensure that experiment is smoothed out, by beginning
A disk position, reduction space-consuming are only needed to whole.
In order to achieve the above object, the technical solution adopted by the present invention is as follows：
A kind of biology, the electromagnetic shaker of chemical substance separation and concentration, including pedestal；It is characterized in that：Set on the pedestal
There are set of sample pans, disk elevating mechanism, heating arrangements, shake mechanism and be mounted with the control module of associated control software；It is described
Disk elevating mechanism includes being used for the disk body for producing magnetic field and the lifting assembly for driving disk body elevating movement, disk body
When rising to certain position, set of sample pans enters in magnetic field range, and when disk body drops to certain position, set of sample pans leaves magnetic
Field scope；The heating arrangements include being arranged at the heater for having heating function on set of sample pans；The concussion mechanism includes shake
Swing component, the set of sample pans concussion of concussion Component driver；The disk elevating mechanism and/or concussion mechanism are arranged under set of sample pans
Side；The control module control disk elevating mechanism and/or heating arrangements and/or concussion mechanism cooperating.This equipment is realized
Heating, concussion and the integration of magnetically attractive function, make that the experiment of seperated nuclear acid, albumen or cell is more convenient, and conventional efficient is higher,
Effect is more preferable, and the overall volume of this equipment is smaller.
Preferably, the disk body includes more than one bar magnet and firm banking, and each bar magnet is vertical to be fixed on firm banking
On, bar magnet at least one end band is magnetic, and magnetic field is produced by bar magnet, so as to reach magnetically attractive function.
Preferably, the lifting assembly includes lifting motor, and the lifting screw and lifting nut being mutually spirally connected, and lifts spiral shell
Bar (or lifting nut) is fixedly connected with the firm banking in disk body, lifting motor driving lifting nut (or lifting screw) positioning
Rotate；Or the lifting assembly includes lift cylinder, the cylinder body of the cylinder is vertical to be fixed on pedestal, body of rod connection disk
Firm banking in body；Or the lifting assembly includes hoist cylinder, the cylinder body of the oil cylinder is vertical to be fixed on pedestal, bar
Firm banking in body connection disk body.Elevating movement for disk body can be driven according to being actually needed using any of the above-described kind
Structure is realized.
Preferably, the ascending motion of lifting assembly driving disk body is to ensure that magnetic fields are in sample caused by disk body
Product disk seat, heating arrangements and concussion mechanism are advisable；The descending motion of lifting assembly driving disk body is to ensure that disk body produces
Raw magnetic field can not act on set of sample pans, heating arrangements and concussion mechanism and ensure shake mechanism kinematic when not with disk
Body, which produces collision, to be advisable.
Preferably, the concussion component includes concussion transmission belt, concussion motor, concussion drive link and concussion plate, concussion electricity
Machine is fixedly installed on pedestal, and concussion drive link locating rotation shakes the output shaft of motor by shaking transmission belt on pedestal
Driving concussion drive rod rotation, shake and be provided with eccentric wheel between drive link and concussion plate, eccentric wheel is fixedly and coaxially connected concussion
Drive link, and eccentric rotary connection concussion plate, concussion plate are fixedly connected with set of sample pans；Concussion for set of sample pans can be by upper
State structure realization.
Escape groove is provided with the middle part of the concussion plate, disk body is lifted in the escape groove, and escape groove and disk body are mutual
Gap type coordinates, and effectively avoids concussion plate from being influenced each other with disk body.
Preferably, the heater is heating wire, heating film and/or heat-generating pipe being arranged on set of sample pans etc..
Compared with prior art, the advantage of the invention is that：
1. a structure avoids sample back and forth by the way that heating function, concussion function and magnetically attractive function are integrated in into one
Transfer, ensure that the experimental procedures such as heating, concussion and magnetically attractive can link up and smoothly complete, effectively shorten experimentation, make experiment
Efficiency improves, and can guarantee that the combination of nucleic acid and magnetic bead.
2. a structure does not need gripper to grip transfer sample back and forth, effective to reduce the chance of equipment error, and can shut out
The phenomenon that microwell plate drops from gripper in exhausted transfer process, the effective accuracy for ensureing experimental result.
3. a structure, when carrying out separating experiment, each sample only can need to be completed to test on fixed disk position, therefore not
Need to take more disk positions in the card of liquor removing workstation, not only effectively reduce manufacturing cost, and overall volume contracts
Small, the space-consuming of equipment is less.
Brief description of the drawings
In order to illustrate more clearly about the embodiment of the present invention or technical scheme of the prior art, below will be to embodiment or existing
There is the required accompanying drawing used in technology description to be briefly described, it should be apparent that, drawings in the following description are only this
Some embodiments of invention, for those of ordinary skill in the art, on the premise of not paying creative work, can be with
Other accompanying drawings are obtained according to these accompanying drawings.
Fig. 1 is the structural representation of biological, chemical substance separation and concentration electromagnetic shaker of the present invention；
Fig. 2 is another structural representation of biological, chemical substance separation and concentration electromagnetic shaker of the present invention；
Fig. 3 is the front view of biological, chemical substance separation and concentration electromagnetic shaker of the present invention.
Description of reference numerals：Set of sample pans 1, disk body 2, bar magnet 21, firm banking 22, concussion transmission belt 3, concussion motor
4th, lifting motor 5, pedestal 6, concussion drive link 7, concussion plate 8.
Embodiment
In order that the objects, technical solutions and advantages of the present invention more clearly, are entered to the present invention with reference to embodiments
Row is further described, but the scope of protection of present invention is not limited to following specific embodiments.
Refering to shown in Fig. 1 and Fig. 3, this biology, the electromagnetic shaker of chemical substance separation and concentration, including pedestal 6, on the pedestal 6
Set of sample pans 1, disk elevating mechanism are provided with, heating arrangements, mechanism is shaken and is mounted with the control module of associated control software；
Set of sample pans 1 is used to carry microwell plate；Disk elevating mechanism includes being used to produce the disk body 2 in magnetic field and for driving disk body
The lifting assembly of 2 elevating movements, when disk body 2 rises to certain position, the microwell plate on set of sample pans 1 enters magnetic field range
Interior, to reach magnetically attractive function, when disk body 2 drops to certain position, the microwell plate on set of sample pans 1 leaves magnetic field range, with
Exempt to influence other mask works；Heating arrangements include being arranged at the heater for having heating function on set of sample pans 1；Shake mechanism bag
Concussion component is included, concussion Component driver set of sample pans 1 shakes；Disk elevating mechanism and concussion mechanism are respectively arranged at set of sample pans
1 lower section；Control module controls disk elevating mechanism and/or heating arrangements and/or concussion mechanism cooperating.This structure will add
Heat, concussion are integrated in an equipment with magnetically attractive function, make the experiment of seperated nuclear acid, albumen or cell more convenient, conventional efficient
Higher, effect is more preferable, and the overall volume of this equipment is smaller.
Disk body 2 includes more than one bar magnet 21 and firm banking 22, and each side-by-side of bar magnet 21 is stood on firm banking 22,
The top band of bar magnet 21 is magnetic, and carrying magnetic, the band magnetic end of bar magnet 21 do not produce magnetic field, effectively reactant carried out at bottom end
Magnetically attractive.
Lifting assembly includes lifting motor 5, and the lifting screw and lifting nut being mutually spirally connected, lifting screw are fixedly connected
Firm banking 22 in disk body 2, lifting motor 5 drive lifting nut locating rotation, using the effect of screw-driven, pass through liter
Drop screw rod and lifting nut can drive the elevating movement of disk body 2, to control the microwell plate on set of sample pans 1 to enter magnetic field or leave
Magnetic field, simple in construction, simple operation.
The ascending motion of lifting assembly driving disk body 2 is to ensure that magnetic fields are on set of sample pans 1 caused by disk body 2
Microwell plate, heating arrangements and concussion mechanism be advisable；The descending motion of lifting assembly driving disk body 2 is to ensure disk body
Microwell plate that magnetic field caused by 2 can not be acted on set of sample pans 1, heating arrangements and concussion mechanism and ensure to shake mechanism
Not producing collision with disk body 2 during motion is advisable.
Shaking component includes concussion transmission belt 3, concussion motor 4, concussion drive link 7 and concussion plate 8, and concussion motor 4 is fixed
It is arranged on pedestal 6, on pedestal 6, the output shaft of concussion motor 4 is driven the concussion locating rotation of drive link 7 by shaking transmission belt 3
Dynamic concussion drive link 7 rotates, and shakes and is provided with eccentric wheel between drive link 7 and concussion plate 8, eccentric wheel is fixedly and coaxially connected concussion
The top of drive link 7, and eccentric rotary connection concussion plate 8 bottom, concussion plate 8 are fixedly connected with set of sample pans 1, utilize the inclined of eccentric wheel
Heart motion makes concussion plate 8 drive set of sample pans 1 to produce concussion effect, and then shakes microwell plate.
The middle part of concussion plate 8 is provided with escape groove, and disk body 2 is lifted in the escape groove, escape groove and 2 mutual gap of disk body
Formula coordinates, and effectively avoids concussion work of the lifting work of magnetic 2 with shaking plate 8 from influencing each other.
Heater is the heating wire, heating film and/or heat-generating pipe being arranged on set of sample pans 1, to add to microwell plate
Heat.
Concrete operating principle：
When needing that the reaction system in microwell plate is heated and/or shaken, it can be controlled and heated by control software
The heating-up temperature, concussion speed and concussion time of mechanism are shaken, appropriate heating and/or shake are carried out to the reactant in microwell plate
Swing, it is ensured that obtain accurate experimental result.
When needing to carry out magnetically attractive to the reaction system in microwell plate, control software controls disk elevating mechanism by disk body
2 are raised to suitable height, make magnetic fields caused by disk body 2 in whole heating concussion mechanism and microwell plate.
When magnetically attractive is finished, it is necessary to when cancelling the magnetic field acted on reactant, control software control disk elevating mechanism will
Disk body 2 drops to suitable height, prevents magnetic field caused by disk body 2 from acting on heating concussion mechanism and microwell plate, and
And ensure not produce collision with disk body 2 during heating concussion mechanism kinematic.
Although being described in conjunction with the accompanying embodiments of the present invention, patent owner can be in appended claims
Within the scope of make various deformations or amendments, as long as no more than the present invention claim described by protection domain, all should
Within protection scope of the present invention.
Claims (7)
1. a kind of biology, the electromagnetic shaker of chemical substance separation and concentration, including pedestal (6)；It is characterized in that：On the pedestal (6)
Set of sample pans (1), disk elevating mechanism are provided with, heating arrangements, mechanism is shaken and is mounted with the control mould of associated control software
Block；The disk elevating mechanism includes being used for the disk body (2) for producing magnetic field and the liter for driving disk body (2) elevating movement
Come down to a lower group part, when disk body (2) rises to certain position, set of sample pans (1) enters in magnetic field range, and disk body (2) drops to one
When positioning is put, set of sample pans (1) leaves magnetic field range；The heating arrangements include being arranged at tool heating work(on set of sample pans (1)
The heater of energy；The concussion mechanism includes concussion component, concussion Component driver set of sample pans (1) concussion；The disk lifting
Mechanism and/or concussion mechanism are arranged at below set of sample pans (1)；The control module control disk elevating mechanism and/or heating
Mechanism and/or concussion mechanism cooperating.
2. biology according to claim 1, the electromagnetic shaker of chemical substance separation and concentration, it is characterised in that：The disk body
(2) more than one bar magnet (21) and firm banking (22) are included, each bar magnet (21) is vertical to be fixed on firm banking (22), bar magnet
(21) at least one end band is magnetic.
3. biology according to claim 1, the electromagnetic shaker of chemical substance separation and concentration, it is characterised in that：The lifting group
Part includes lifting motor (5), and the lifting screw and lifting nut being mutually spirally connected, lifting screw (or lifting nut) are fixedly connected
Disk body (2), lifting motor (5) driving lifting nut (or lifting screw) locating rotation；
Or the lifting assembly includes lift cylinder, the cylinder body of the cylinder is vertical to be fixed on pedestal (6), body of rod connection magnetic
Disk body (2)；
Or the lifting assembly includes hoist cylinder, the cylinder body of the oil cylinder is vertical to be fixed on pedestal (6), body of rod connection magnetic
Disk body (2).
4. biology according to claim 1, the electromagnetic shaker of chemical substance separation and concentration, it is characterised in that：The lifting group
The ascending motion of part driving disk body (2) is to ensure that magnetic fields are in set of sample pans (1), heating arrangements caused by disk body (2)
And concussion mechanism is advisable；The descending motion of lifting assembly driving disk body (2) is to ensure that magnetic field is not caused by disk body (2)
Set of sample pans (1), heating arrangements and concussion mechanism can be acted on and do not produced when ensureing to shake mechanism kinematic with disk body (2)
Raw collision is advisable.
5. biology according to claim 1, the electromagnetic shaker of chemical substance separation and concentration, it is characterised in that：The concussion group
Part includes concussion transmission belt (3), concussion motor (4), concussion drive link (7) and concussion plate (8), concussion motor (4) fixed setting
In on pedestal (6), on pedestal (6), the output shaft of concussion motor (4) is driven concussion drive link (7) locating rotation by shaking
Band (3) driving concussion drive link (7) rotates, and is provided with eccentric wheel between concussion drive link (7) and concussion plate (8), eccentric wheel is same
Axle is fixedly connected with concussion drive link (7), and eccentric rotary connection concussion plate (8), and concussion plate (8) is fixedly connected with set of sample pans (1).
6. biology according to claim 5, the electromagnetic shaker of chemical substance separation and concentration, it is characterised in that：The concussion plate
(8) middle part is provided with escape groove, and disk body (2) is lifted in the escape groove, and escape groove coordinates with disk body (2) mutually clearance-type.
7. biology according to claim 1, the electromagnetic shaker of chemical substance separation and concentration, it is characterised in that：The heater
For heating wire, heating film and/or the heat-generating pipe being arranged on set of sample pans (1).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710961516.6A CN107586716A (en) | 2017-10-16 | 2017-10-16 | A kind of biology, the electromagnetic shaker of chemical substance separation and concentration |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710961516.6A CN107586716A (en) | 2017-10-16 | 2017-10-16 | A kind of biology, the electromagnetic shaker of chemical substance separation and concentration |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107586716A true CN107586716A (en) | 2018-01-16 |
Family
ID=61052338
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710961516.6A Withdrawn CN107586716A (en) | 2017-10-16 | 2017-10-16 | A kind of biology, the electromagnetic shaker of chemical substance separation and concentration |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107586716A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109776668A (en) * | 2018-04-02 | 2019-05-21 | 充烜金 | The concussion purifier of Recombinant Chinese cobra NGF |
| CN109974788A (en) * | 2019-04-24 | 2019-07-05 | 西南交通大学 | One kind being based on micro-processor controlled chemistry experiment box |
| CN113198360A (en) * | 2021-04-30 | 2021-08-03 | 重庆微浪自动化设备有限公司 | Vibrating magnetic equipment and vibrating magnetic attraction method for biological sample |
-
2017
- 2017-10-16 CN CN201710961516.6A patent/CN107586716A/en not_active Withdrawn
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109776668A (en) * | 2018-04-02 | 2019-05-21 | 充烜金 | The concussion purifier of Recombinant Chinese cobra NGF |
| CN109776668B (en) * | 2018-04-02 | 2022-03-11 | 河南中医药大学第一附属医院 | Concussion purifier for recombinant nerve growth factor |
| CN109974788A (en) * | 2019-04-24 | 2019-07-05 | 西南交通大学 | One kind being based on micro-processor controlled chemistry experiment box |
| CN113198360A (en) * | 2021-04-30 | 2021-08-03 | 重庆微浪自动化设备有限公司 | Vibrating magnetic equipment and vibrating magnetic attraction method for biological sample |
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| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20180116 |