CN107550936A - A kind of gestational period allergic rhinitis irrigation - Google Patents
A kind of gestational period allergic rhinitis irrigation Download PDFInfo
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- CN107550936A CN107550936A CN201710870013.8A CN201710870013A CN107550936A CN 107550936 A CN107550936 A CN 107550936A CN 201710870013 A CN201710870013 A CN 201710870013A CN 107550936 A CN107550936 A CN 107550936A
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- yolk
- gestational period
- allergic rhinitis
- irrigation
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Abstract
The present invention relates to biological medicine and medical instruments field, and in particular to a kind of gestational period allergic rhinitis irrigation, it is characterised in that raw material is prepared by following mass percents：Security Oleum Ovum Gallus domesticus Flavus 1~10%, emulsifying agent 1~3%, sodium chloride 0.9%, purified water polishing to 100%.The beneficial effects of the present invention are safe to use without organic solvent without carcinogenic substance BaP；Easy to use, composition is natural, and formula is soft, and nasal cavity can be moistened after flushing, mitigates schneiderian membrance hyperemia, effectively alleviates the allergic symptoms such as gestational period nasal obstruction, foetus health will not be damaged again.
Description
Technical field
The present invention relates to biological medicine and medical instruments field, more particularly to a kind of gestational period allergic rhinitis irrigation.
Background technology
Because gestational period pregnant woman's hormone in vivo level increase, schneiderian membrance H1 acceptors are acted on, cause the hypersensitivity of schneiderian membrance,
Cause thin vessels extension, tissue edema, glandular secretion is vigorous, allergic reaction occurs.There are the pregnant woman of gestational period allergic rhinitis, meeting
There is nasal obstruction, rhiocnesmus, rhinorrhea, the symptom of sneezing, can not only influence sleep of pregnant woman, frequent mouth breathing influences the filtration of nasal cavity
And humidification function, cause patient uncomfortable, more serious possibility has that snore disease is relevant, and snore disease be pregnancy period hypertension, pre-eclampsia and
The high risk factor of fetal intrauterine growth retardation, it is seen that rhinitis not only produces physiology, psychological impact to pregnant woman, in some instances it may even be possible to has influence on
Fetus.The incidence of disease of gestational period rhinitis is higher, and clinical treatment has particularity, it is necessary to which careful medication, avoids fetal intelligence from developing
Bad or lopsided situation occurs, and the method for Reduce allergy rhinitis safer at present is to use normal saline flushing nose
Chamber, but mycteroxerosis can be caused uncomfortable, and therapeutic effect is limited.
Oleum Ovum Gallus domesticus Flavus are extracted by egg yolk, existing higher edibility, there is certain medical value, Oleum Ovum Gallus domesticus Flavus again
With it is clearing heat and detoxicating the effect of, modern clinical research it has proven convenient that Oleum Ovum Gallus domesticus Flavus have preferable therapeutic effect to rhinitis, meanwhile,
Oleum Ovum Gallus domesticus Flavus contain a variety of lipids, vitamin, have the function that good nourishes rough skin, reduce inflammation.Produce egg yolk at present
The method of oil is mainly traditional cracking process, drying method, chloroform extraction, ethanol extraction method, supercritical CO2Extraction, subcritical third
Alkane extraction, Enzymatic Extraction, chromatogram extraction method.Traditional cracking process and drying method generate carcinogenic substance BaP due to high temperature, and raw
A large amount of smoke pollution of environment are produced in production；Chloroform extraction and ethanol extraction method are industrial used method, using a large amount of
Organic solvent, the problem of organic solvent residual be present；Supercritical CO2Extraction and Propane extraction big energy-consuming, need height
Pressure ring border, and production cost is high, although the good product quality of its separation, composition can reach single, this method yields poorly unrealized
Industrialization；Enzymatic Extraction has the advantages of technique is simple, but Lecithin Content is substantially free of in product；The processing of chromatogram extraction method
Measure limited, product composition is single, problem of solvent residual be present.It can be seen that carcinogenic substance and organic solvent are to produce Oleum Ovum Gallus domesticus Flavus at present
In inevitable composition, these harmful components can cause potential threat to the health of human body, are particularly not suitable for the gestational period and use.
The invention for preventing and treating egg oil rhinitis at present has also been reported, such as Application No. 201510337361.X China
Patent of invention " egg oil of egg oil and removal BaP is preparing the application in treating allergic rhinitis medicine ", it uses baking
Egg oil is baked to obtain, charcoal absorption removing is carried out to caused BaP using activated carbon afterwards, but the method is more extensive, it is difficult
To ensure that BaP is removed totally, still there is potential hazard in the treatment of rhinitis.Therefore, develop a without BaP
The Oleum Ovum Gallus domesticus Flavus rhinitis product that the gestational period uses is very necessary.
The content of the invention
It is an object of the invention to provide a kind of gestational period allergic rhinitis irrigation, without harmful substance BaP, rinses
After can moisten nasal cavity, it is congested to mitigate schneiderian membrance, alleviates the allergic symptoms such as nasal obstruction, to reach above-mentioned purpose, the present invention is using following
Technical scheme：
A kind of gestational period allergic rhinitis irrigation, it is characterised in that raw material is prepared by following mass percents：
Security Oleum Ovum Gallus domesticus Flavus 1~10%, emulsifying agent 1~3%, sodium chloride 0.9%, purified water polishing to 100%.
Described emulsifying agent is including but not limited to D-mannital, glycerine, single, double fatty acid glyceride, phosphatide, lactose
Alcohol, D-sorbite, pungent, glycerol decanoate, the one or more in the single, double fatty acid glyceride of acetylation.
A kind of security Oleum Ovum Gallus domesticus Flavus are produced according to the following steps：
（1）Freshly-slaughtered poultry yolk is stocked up：The egg for selecting freshness >=72Ha is separated using equipment progress yolk with egg white, collects yolk
Film does not rupture, the complete yolk of form；
（2）Ultrasound pretreatment：Yolk is subjected to ultrasonication, 25~50kHz of processing frequency, 5~15min of processing time, with
Increase the permeability of egg membrane and destroy the emulsion stability of albumen and lipid in yolk；
（3）Hot-cold processing：The egg yolk complete to ultrasonication carries out hot-cold processing, using Hot-blast Heating, temperature 45~55
DEG C, 10~20min is kept, chilling treatment is carried out afterwards, 5~8 DEG C for the treatment of temperature, 20~30min is kept, further to destroy yolk
The emulsion stability of middle albumen and lipid；
（4）Configure pickling liquid：By food-grade osmotic pressure regulator of the mass fraction for 1~40%, 0.1~10% food-grade acidity tune
Agent, 0.1~5% food grade antioxidants, purified water polishing to 100% are saved, after stirring and dissolving, boiling sterilization is carried out, cools to room
Temperature；
（5）Pickle：Processed egg yolk is placed in pickling liquid, the two weight ratio is 1:3~1：1, add into pickling liquid
Enter the edible salt of final concentration of mass fraction 4%~10%, add by several times to form salt gradient, keep clean environment, temperature 30~
40 DEG C are pickled 36~48h, 70 DEG C of 2~5h of curing；
（6）Centrifugation：Clean after pickling the egg yolk obtained and crushed, use industrial centrifugal machine collected after centrifugation fluid；
（7）Desalination：The purified water of 2~5 times of weight is added into the fluid of collection, repeats 2~5 times, is stood after being gently mixed
Layering, retain upper strata fluid；
（8）Deodorize：Due in egg yolk curing process, there is volatile flavor substance, vacuum is used to deodorize to reduce flavor substances
Matter content；
（9）Decolourize：A certain amount of activated carbon is added, the pigment in Oleum Ovum Gallus domesticus Flavus and the flavor substance not purified is adsorbed, makes egg
Butter color and luster and taste are purer, and this finished product is Oleum Ovum Gallus domesticus Flavus finished product.
Above-mentioned steps（4）Described osmotic pressure regulator include but is not limited to sucrose, D-mannital, glycerine, carragheen,
One or more in xanthans.
Above-mentioned steps（4）Described acidity regulator include but is not limited to acetic acid, phosphoric acid, hydrochloric acid, malic acid, citric acid,
One or more in lactic acid.
Above-mentioned steps（4）Described antioxidant includes but is not limited to vitamin C.
A kind of gestational period allergic rhinitis irrigation, is prepared in accordance with the following steps：
（10）It is homogeneous：Security Oleum Ovum Gallus domesticus Flavus, emulsifying agent, sodium chloride, purified water are transferred in vacuum homogeneous mulser, rotating speed is
2500~2800r/min, normal temperature, homogeneous 30~60min, obtain emulsion；
（11）Sterilizing：Irradiation sterilization；
（12）Packaging：It is aseptic subpackaged to produce a kind of gestational period allergic rhinitis irrigation.
The beneficial effects of the invention are as follows：Due to Oleum Ovum Gallus domesticus Flavus extraction without high-temperature process, without using organic solvent, therefore
Carcinogenic substance BaP is free of in the Oleum Ovum Gallus domesticus Flavus of extraction, organic solvent-free remains, and safety in utilization is higher；It is easy to use, composition
Naturally, it is formulated soft, can moistens nasal cavity after flushing, it is congested to mitigate schneiderian membrance, and the effectively alleviation gestational period such as has a stuffy nose at the allergic symptom, again
Foetus health will not be damaged.
Embodiment
Following examples are used to illustrate the present invention, but are not limited to the scope of the present invention.
Embodiment 1
In market purchasing freshness >=72Ha 1000 pieces of egg, separated using yolk-egg white seperator, collect vitellinae membrana
Complete uncracked yolk, weight in wet base 17.59kg.The egg yolk of collection is ultrasonically treated using supersonic wave cleaning machine, set
Power 25kHz, handle 5min.Egg yolk after ultrasound is transferred to hot-air oven, design temperature is 45 DEG C, dries 15min, transfer
To refrigerator, 5 DEG C of temperature, taken out after refrigerating 30min.Pickling liquid 30kg is prepared, 9kg glycerine, 1kg second are added into rustless steel container
Acid, 0.2kg vitamin Cs, purified water 19.8kg, stir, and 20min is boiled in heating, cool to room temperature, are taken out after adding refrigeration
Egg yolk, be placed in clean environment, set 35 DEG C of temperature, into pickling liquid add salt 0.06kg, be gently mixed to dissolving,
Often cross 1h and add salt 0.06kg, pickle 48h, be allowed to dry pickling liquid, 70 DEG C of curing 5h, clean egg yolk and crush, use industry
Centrifuge is centrifuged, rotating speed 4000r/min, retains centrifugation fluid 5.4kg.Purified water 26.5kg is added into centrifugation fluid,
Rear stratification is gently mixed, retains upper strata fluid, vacuum is deodorized, 40 DEG C of temperature, vacuum -0.04Mpa, time 30min, added
Enter activated carbon granule 1kg, precipitation filters to obtain Oleum Ovum Gallus domesticus Flavus 5.3kg after standing 2h, by 5.3kg egg oils, 0.79kg D-sorbites,
0.84kg acetyl diglycerine fatty acid ester, 0.64kg sodium chloride, 63.14kg purified waters are transferred in vacuum homogeneous mulser, rotating speed
For 2600r/min, the homogeneous 45min of normal temperature, dispense after irradiation sterilization, as a kind of gestational period allergic rhinitis irrigation.
Embodiment 2
In market purchasing freshness >=72Ha 2000 pieces of egg, separated using yolk-egg white seperator, collect vitellinae membrana
Complete uncracked yolk, weight in wet base 36.22kg.The egg yolk of collection is ultrasonically treated using supersonic wave cleaning machine, set
Power 30kHz, handle 5min.Egg yolk after ultrasound is transferred to hot-air oven, design temperature is 50 DEG C, dries 10min, transfer
To refrigerator, 6 DEG C of temperature, taken out after refrigerating 30min.Pickling liquid 60kg is prepared, 9kg glycerine, 5kg sugarcanes are added into rustless steel container
Sugar, 0.7kg carragheens, 1kg acetic acid, 0.5kg phosphoric acid, 0.5kg vitamin Cs, purified water 43.3kg, stir, heating is boiled
20min, cool to room temperature, add after refrigeration the egg yolk taken out, be placed in clean environment, 40 DEG C of temperature is set, to pickling liquid
Middle addition salt 0.1kg, it is gently mixed to dissolving, often crosses 1h and add salt 0.12kg, pickle 48h, be allowed to dry pickling liquid, 70 DEG C ripe
Change 5h, clean egg yolk and crush, centrifuged using industrial centrifugal machine, rotating speed 4000r/min, retain centrifugation fluid
11.6kg.Purified water 45.6kg is added into centrifugation fluid, is gently mixed rear stratification, retains upper strata fluid, repeats washing 2
Retain final upper strata fluid after secondary, vacuum is deodorized, and 40 DEG C, vacuum -0.04Mpa, time 30min of temperature, adds activated carbon
Particle 3kg, precipitation stand 2h after filter to obtain Oleum Ovum Gallus domesticus Flavus 11.4kg, by 11.4kg egg oils, 0.73kg diglycerine fatty acid esters,
1.92kg glycerine, 1.02kg glycerol decanoates, 1.84kg sodium chloride, 187.07kg purified waters are transferred in vacuum homogeneous mulser,
Rotating speed is 2600r/min, the homogeneous 55min of normal temperature, is dispensed after irradiation sterilization, as a kind of gestational period allergic rhinitis irrigation.
Claims (5)
1. a kind of gestational period allergic rhinitis irrigation, it is characterised in that raw material is prepared by following mass percents：
Security Oleum Ovum Gallus domesticus Flavus 1~10%, emulsifying agent 1~3%, sodium chloride 0.9%, purified water polishing to 100%；
A kind of security Oleum Ovum Gallus domesticus Flavus are produced according to the following steps：
（1）Freshly-slaughtered poultry yolk is stocked up：The egg for selecting freshness >=72Ha is separated using equipment progress yolk with egg white, collects yolk
Film does not rupture, the complete yolk of form；
（2）Ultrasound pretreatment：Yolk is subjected to ultrasonication, 25~50kHz of processing frequency, 5~15min of processing time, with
Increase the permeability of egg membrane and destroy the emulsion stability of albumen and lipid in yolk；
（3）Hot-cold processing：The egg yolk complete to ultrasonication carries out hot-cold processing, using Hot-blast Heating, temperature 45~55
DEG C, 10~20min is kept, chilling treatment is carried out afterwards, 5~8 DEG C for the treatment of temperature, 20~30min is kept, further to destroy yolk
The emulsion stability of middle albumen and lipid；
（4）Configure pickling liquid：By food-grade osmotic pressure regulator of the mass fraction for 1~40%, 0.1~10% food-grade acidity tune
Agent, 0.1~5% food grade antioxidants, purified water polishing to 100% are saved, after stirring and dissolving, boiling sterilization is carried out, cools to room
Temperature；
（5）Pickle：Processed egg yolk is placed in pickling liquid, the two weight ratio is 1:3~1：1, add into pickling liquid
Enter the edible salt of final concentration of mass fraction 4%~10%, add by several times to form salt gradient, keep clean environment, temperature 30~
40 DEG C are pickled 36~48h, 70 DEG C of 2~5h of curing；
（6）Centrifugation：Clean after pickling the egg yolk obtained and crushed, use industrial centrifugal machine collected after centrifugation fluid；
（7）Desalination：The purified water of 2~5 times of weight is added into the fluid of collection, repeats 2~5 times, is stood after being gently mixed
Layering, retain upper strata fluid；
（8）Deodorize：Due in egg yolk curing process, there is volatile flavor substance, vacuum is used to deodorize to reduce flavor substances
Matter content；
（9）Decolourize：A certain amount of activated carbon is added, the pigment in Oleum Ovum Gallus domesticus Flavus and the flavor substance not purified is adsorbed, makes egg
Butter color and luster and taste are purer, and this finished product is Oleum Ovum Gallus domesticus Flavus finished product；
A kind of gestational period allergic rhinitis irrigation, is prepared in accordance with the following steps：
（10）It is homogeneous：Security Oleum Ovum Gallus domesticus Flavus, emulsifying agent, sodium chloride, purified water are transferred in vacuum homogeneous mulser, rotating speed is
2500~2800r/min, normal temperature, homogeneous 30~60min, obtain emulsion；
（11）Sterilizing：Irradiation sterilization；
（12）Packaging：It is aseptic subpackaged to produce a kind of gestational period allergic rhinitis irrigation.
A kind of 2. gestational period allergic rhinitis irrigation according to claim 1, it is characterised in that described emulsifying agent bag
Contain but be not limited to D-mannital, glycerine, single, double fatty acid glyceride, phosphatide, lactitol, D-sorbite, pungent, capric acid glycerine
Ester, the one or more in the single, double fatty acid glyceride of acetylation.
A kind of 3. gestational period allergic rhinitis irrigation according to claim 1, it is characterised in that step（4）Described oozes
The one or more that pressure conditioning agent includes but is not limited in sucrose, D-mannital, glycerine, carragheen, xanthans thoroughly.
A kind of 4. gestational period allergic rhinitis irrigation according to claim 1, it is characterised in that step（4）Described acid
The one or more that degree conditioning agent includes but is not limited in acetic acid, phosphoric acid, hydrochloric acid, malic acid, citric acid, lactic acid.
A kind of 5. gestational period allergic rhinitis irrigation according to claim 1, it is characterised in that step（4）Described is anti-
Oxidant includes but is not limited to vitamin C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710870013.8A CN107550936A (en) | 2017-09-23 | 2017-09-23 | A kind of gestational period allergic rhinitis irrigation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710870013.8A CN107550936A (en) | 2017-09-23 | 2017-09-23 | A kind of gestational period allergic rhinitis irrigation |
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| Publication Number | Publication Date |
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| CN107550936A true CN107550936A (en) | 2018-01-09 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710870013.8A Withdrawn CN107550936A (en) | 2017-09-23 | 2017-09-23 | A kind of gestational period allergic rhinitis irrigation |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104958321A (en) * | 2015-06-17 | 2015-10-07 | 哈尔滨医科大学 | Egg yolk oil and application of egg yolk oil with benzopyrene removed in preparation of drugs for allergic rhinitis |
| CN107083269A (en) * | 2017-04-01 | 2017-08-22 | 新疆喀什昆仑翠翎鸽业有限责任公司 | One kind is without BaP pigeon eggs butter and preparation method thereof |
-
2017
- 2017-09-23 CN CN201710870013.8A patent/CN107550936A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104958321A (en) * | 2015-06-17 | 2015-10-07 | 哈尔滨医科大学 | Egg yolk oil and application of egg yolk oil with benzopyrene removed in preparation of drugs for allergic rhinitis |
| CN107083269A (en) * | 2017-04-01 | 2017-08-22 | 新疆喀什昆仑翠翎鸽业有限责任公司 | One kind is without BaP pigeon eggs butter and preparation method thereof |
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Application publication date: 20180109 |
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