CN107550450A - A kind of fluorescence endoscopy system for bronchial disease early diagnosis - Google Patents
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Abstract
本发明公开了一种用于支气管疾病早期诊断的荧光内窥镜系统，包括主控制器、光源单元、内窥镜单元、检测单元、云服务器和显示单元，云服务器通过互联网与主控制器相连，显示单元通过USB接口与主控制器相连，主控制器通过电缆分别与光源单元和检测单元相连接，光源单元和检测单元分别通过光纤与内窥镜单元相连接。本发明通过光谱成像技术，实现了对支气管位置的高分辨率、高精度光谱成像，同时通过互联网将图像信息传输至云服务器，实现了数据的实时共享和辅助诊断。
The invention discloses a fluorescent endoscope system for early diagnosis of bronchial diseases, which comprises a main controller, a light source unit, an endoscope unit, a detection unit, a cloud server and a display unit, and the cloud server is connected to the main controller through the Internet , the display unit is connected to the main controller through the USB interface, the main controller is connected to the light source unit and the detection unit respectively through cables, and the light source unit and the detection unit are respectively connected to the endoscope unit through optical fibers. The present invention realizes high-resolution and high-precision spectral imaging of the bronchial position through spectral imaging technology, and at the same time transmits image information to a cloud server through the Internet, thereby realizing real-time data sharing and auxiliary diagnosis.
Description
技术领域technical field
本发明属于光学成像技术领域，尤其涉及一种用于支气管疾病早期诊断的荧光内窥镜系统。The invention belongs to the technical field of optical imaging, in particular to a fluorescence endoscope system for early diagnosis of bronchial diseases.
背景技术Background technique
内窥镜技术是现代医疗诊断必不可少的仪器之一，通过内窥镜可以直接对人体内器官进行观察，对于支气管等疾病的早期诊断具有重要意义。Endoscope technology is one of the indispensable instruments for modern medical diagnosis. Endoscopes can directly observe the internal organs of the human body, which is of great significance for the early diagnosis of diseases such as bronchi.
临床经验表明，对于支气管等疾病，早期诊断非常重要，于是能够实现高分辨光谱成像的荧光内窥镜技术越来越受到重视。光谱成像技术是一种将光谱技术与光学成像技术完美结合而产生的成像技术，多光谱成像技术是一种在光谱成像基础之上发展起来的一种新型成像技术，它可以以不同物体对不同波长光线的吸收存在差异为原理，通过对目标物体对一组不同波长的光线中光强度的变化来实现对目标物体进行检测、辨别等应用。在目前的临床研究中将多光谱成像技术与临床诊断相结合，通过显微内窥成像技术同时实现二者的获取，不仅极大地提高了检测灵敏度，而且获得了分子水平样品生物化学信息，为癌症、支气管等疾病的临床诊断提供了重要依据。现有诊断技术的弊端一方面由于诊断设备性能的限制，另一方面由于医生的主观判断的误差与医疗水平的参差不齐。Clinical experience shows that for diseases such as bronchi, early diagnosis is very important, so fluorescence endoscopy technology that can achieve high-resolution spectral imaging has attracted more and more attention. Spectral imaging technology is an imaging technology that perfectly combines spectral technology and optical imaging technology. Multispectral imaging technology is a new type of imaging technology developed on the basis of spectral imaging. The principle is that there are differences in the absorption of wavelength light, and the application of detecting and distinguishing the target object is realized by changing the light intensity of the target object to a group of light of different wavelengths. In the current clinical research, the combination of multispectral imaging technology and clinical diagnosis, and the acquisition of both through microendoscopic imaging technology, not only greatly improved the detection sensitivity, but also obtained the biochemical information of the sample at the molecular level. It provides an important basis for the clinical diagnosis of cancer, bronchus and other diseases. The drawbacks of existing diagnostic techniques are due to the limitation of diagnostic equipment performance on the one hand, and the unevenness of doctors' subjective judgment and medical level on the other hand.
CN102697449A公开了一种内窥镜用光源装置，连接于或者安装于向体腔内射出经由光导向设备导出的光的内窥镜，所述内窥镜用光源装置具备：激光器光源部，至少具有第1及第2激光器光源，所述第1激光器光源产生第1激光，所述第2激光器光源产生中心波长与所述第1激光不同的第2激光；波长变换部，配置成入射所述第1及第2激光，并将所述第1激光变换成白色光，向该白色光射出混合了第2激光的照明光，来自所述波长变换部的照明光入射到所述光导向设备。该装置无法对不同波长的光进行选择。CN102697449A discloses a light source device for an endoscope, which is connected or installed to an endoscope that emits light guided through a light guide device into a body cavity. The light source device for an endoscope includes: a laser light source unit having at least a 1 and a second laser light source, the first laser light source generates a first laser light, the second laser light source generates a second laser light with a center wavelength different from that of the first laser light; and the second laser light, convert the first laser light into white light, emit illumination light mixed with the second laser light to the white light, and the illumination light from the wavelength conversion unit enters the light guide device. The device cannot select between different wavelengths of light.
CN103315711B公开了一种医用经内窥镜切伦科夫发光成像系统，所述系统包括：内窥镜探头，用于采集受检对象表面白光信号和/或受检对象内部靶向目标与探针结合发出的切伦科夫荧光信号；光纤传像束，一端与所述内窥镜探头连接，用于传输所述白光信号和/或所述切伦科夫荧光信号；探测装置，与所述光纤传像束另一端连接，用于将所述经光纤传像束传送的白光信号和/或切伦科夫荧光信号转化为电信号；计算与成像装置，与所述探测装置连接，用于对所述转化后的电信号进行后续处理，获得受检对象表面的白光结构图像和/或受检对象内部靶向目标与探针结合发出的切伦科夫荧光图像。该医用经内窥镜切伦科夫发光成像系统存在成像核素少、成像速度慢、光信号强度低、信号穿透性不足的缺点。CN103315711B discloses a medical endoscopic Cerenkov luminescence imaging system, the system includes: an endoscopic probe for collecting white light signals on the surface of the subject to be examined and/or internal targeting targets and probes of the subject to be examined Combining the emitted Cerenkov fluorescence signal; an optical fiber image transmission bundle, one end of which is connected to the endoscope probe, for transmitting the white light signal and/or the Cerenkov fluorescence signal; a detection device, connected to the endoscopic probe The other end of the optical fiber image transmission bundle is connected to convert the white light signal and/or Cerenkov fluorescence signal transmitted by the optical fiber image transmission bundle into an electrical signal; the calculation and imaging device is connected to the detection device for Subsequent processing is performed on the converted electrical signal to obtain a white light structure image on the surface of the object under inspection and/or a Cerenkov fluorescence image emitted by the combination of the targeted target and the probe inside the object under inspection. The medical transendoscopic Cerenkov luminescence imaging system has the disadvantages of few imaging nuclides, slow imaging speed, low optical signal intensity, and insufficient signal penetration.
而且从现有的公开的技术内容来看，不存在光谱激发与光谱信号采集同步进行的装置。此外，现有的光谱内窥成像技术还存在其它诸多方面的不足，例如：内窥成像系统复杂、体积庞大、造价昂贵、依靠医护人员经验，其准确度、稳定性、成像精度都不能满足目前临床的需求。Moreover, judging from the existing disclosed technical content, there is no device for synchronously performing spectral excitation and spectral signal acquisition. In addition, the existing spectral endoscopic imaging technology still has many other deficiencies, such as: the endoscopic imaging system is complex, bulky, expensive, relying on the experience of medical staff, its accuracy, stability, and imaging precision cannot meet the current requirements. clinical needs.
发明内容Contents of the invention
本发明为避免上述现有技术存在的不足之处，提供了一种用于支气管疾病早期诊断的荧光内窥镜系统，通过光谱成像技术，实现了对支气管位置的高分辨率，高精度光谱成像，同时通过互联网将图像信息传输至云服务器，实现了数据的实时共享与仪器辅助诊断。In order to avoid the shortcomings of the above-mentioned prior art, the present invention provides a fluorescent endoscope system for early diagnosis of bronchial diseases, and realizes high-resolution and high-precision spectral imaging of the position of the bronchus through spectral imaging technology At the same time, the image information is transmitted to the cloud server through the Internet, realizing real-time data sharing and instrument-assisted diagnosis.
本发明所采用的技术方案为：The technical scheme adopted in the present invention is:
一种用于支气管疾病早期诊断的荧光内窥镜系统，包括主控制器、光源单元、内窥镜单元、检测单元、云服务器和显示单元，云服务器通过互联网与主控制器相连，显示单元通过USB接口与主控制器相连，主控制器通过电缆分别与光源单元和检测单元相连接，光源单元和检测单元分别通过光纤与内窥镜单元相连接，主控制器用于控制光源单元、内窥镜单元和检测单元，光源单元用于发出激发光束并将激发光束传导至内窥镜单元，内窥镜单元用于将激发光束导至支气管表面并将支气管表面发出的荧光信号传输至检测单元，检测单元用于对荧光信号进行分光和采集，并将采集到的数据实时传输至主控制器，主控制器将从检测单元传输来的数据传输至云服务器以进行云存储、数据维护以及云计算。A fluorescent endoscope system for early diagnosis of bronchial diseases, including a main controller, a light source unit, an endoscope unit, a detection unit, a cloud server and a display unit, the cloud server is connected to the main controller through the Internet, and the display unit is connected through The USB interface is connected with the main controller, and the main controller is respectively connected with the light source unit and the detection unit through the cable, and the light source unit and the detection unit are respectively connected with the endoscope unit through the optical fiber, and the main controller is used to control the light source unit, the endoscope The unit and the detection unit, the light source unit is used to emit the excitation beam and transmit the excitation beam to the endoscope unit, and the endoscope unit is used to guide the excitation beam to the surface of the bronchus and transmit the fluorescent signal emitted by the surface of the bronchus to the detection unit. The unit is used to split and collect fluorescent signals, and transmit the collected data to the main controller in real time, and the main controller transmits the data transmitted from the detection unit to the cloud server for cloud storage, data maintenance and cloud computing.
所述主控制器包括时序控制模块、波段选择模块、同步触发模块、图像采集模块、光谱处理模块和图像处理模块，波段选择模块用于根据需要进行激发光束的波段选择，时序控制模块和同步触发模块用于控制光源单元和检测单元同时工作，图像采集模块用于接收来自检测部分的数据并将数据传输至光谱处理模块、图像处理模块进行数据处理，同时将数据传输至显示单元进行图像显示。The main controller includes a timing control module, a band selection module, a synchronous trigger module, an image acquisition module, a spectrum processing module and an image processing module, the band selection module is used to select the band of the excitation beam as required, the timing control module and the synchronous trigger The module is used to control the light source unit and the detection unit to work at the same time, the image acquisition module is used to receive the data from the detection part and transmit the data to the spectrum processing module, the image processing module for data processing, and at the same time transmit the data to the display unit for image display.
所述光源单元包括依次排布的发光器件、滤光器件、入射透镜组和入射光纤耦合器，发光器件作为光源发出激发光束，滤光器件用于实现不同波长激发光束的选通，入射透镜组与入射光纤耦合器用以将经滤光器件选通得到的激发光束耦合到用以连接光源单元和内窥镜单元的光纤中并传输至内窥镜单元。The light source unit includes a light-emitting device, a filter device, an incident lens group and an incident fiber coupler arranged in sequence, the light-emitting device emits an excitation beam as a light source, the filter device is used to realize the gating of excitation beams of different wavelengths, and the incident lens group The incident optical fiber coupler is used to couple the excitation light beam gated by the optical filter device into the optical fiber used to connect the light source unit and the endoscope unit and transmit it to the endoscope unit.
所述发光器件包括氙灯、卤素灯、激光器或发光二极管；所述滤光器件包括第一滤光片组、第一声光可调谐滤波器或第一液晶可调谐滤波器。The light-emitting device includes a xenon lamp, a halogen lamp, a laser or a light-emitting diode; the filter device includes a first filter group, a first acousto-optic tunable filter or a first liquid crystal tunable filter.
所述内窥镜单元包括用以进入待检测对象体内采集图像的内窥镜和用以操作内窥镜伸入的操作手柄。The endoscope unit includes an endoscope used to enter the body of the object to be inspected to collect images and an operating handle used to operate the endoscope to insert.
所述检测单元包括依次排布的接收光纤耦合器、接收透镜组、分光器件和成像器件，接收光纤耦合器和接收透镜组用于接收和输出来自内窥镜单元的荧光信号，分光器件用于将传输来的荧光信号进行分光处理，成像器件用于收集经分光处理后的荧光信号并进行图像采集。The detection unit includes a receiving fiber coupler, a receiving lens group, a spectroscopic device and an imaging device arranged in sequence, the receiving fiber coupler and the receiving lens group are used to receive and output the fluorescent signal from the endoscope unit, and the spectroscopic device is used to The transmitted fluorescent signal is subjected to spectroscopic processing, and the imaging device is used to collect the spectroscopically processed fluorescent signal and perform image acquisition.
所述分光器件包括第二滤光片组、第二声光可调谐滤波器或第二液晶可调谐滤波器；所述成像器件包括电荷耦合元件传感器或互补金属氧化物半导体传感器。The spectroscopic device includes a second optical filter group, a second acousto-optic tunable filter or a second liquid crystal tunable filter; the imaging device includes a charge coupled element sensor or a complementary metal oxide semiconductor sensor.
所述云服务器包括云存储模块、数据维护模块和云计算模块，云存储模块用于患者诊断数据的可靠存储与高速读取，数据维护模块用以实现云存储模块中数据的定时清理、更新以及用以实现不同云服务器之间的数据共享，云计算模块用以实现光谱拆分、背景消除和辅助诊断。The cloud server includes a cloud storage module, a data maintenance module and a cloud computing module, the cloud storage module is used for reliable storage and high-speed reading of patient diagnostic data, and the data maintenance module is used to realize the regular cleaning, updating and It is used to realize data sharing between different cloud servers, and the cloud computing module is used to realize spectrum splitting, background elimination and auxiliary diagnosis.
所述显示单元包括显示硬件和操作软件，用以实现图像的显示和内窥镜单元的操作控制。The display unit includes display hardware and operating software to realize image display and operation control of the endoscope unit.
所述显示硬件包括台式电脑、笔记本电脑、掌上电脑、平板电脑或智能手机。The display hardware includes a desktop computer, a notebook computer, a palmtop computer, a tablet computer or a smart phone.
由于采用了上述技术方案，本发明所取得的有益效果为：Owing to adopting above-mentioned technical scheme, the beneficial effect that the present invention obtains is:
1、利用本发明可以实现激发与发射光谱实时成像，操作简单，成像分辨率高，且主控制器外接云服务器，通过网络将图像与荧光信号传输至云服务器，实现了数据的实时共享和辅助诊断，提高了判断的准确性。1. Real-time imaging of excitation and emission spectra can be realized by using the present invention, with simple operation and high imaging resolution, and the main controller is externally connected to a cloud server, and images and fluorescence signals are transmitted to the cloud server through the network, realizing real-time data sharing and assistance Diagnosis improves the accuracy of judgment.
2、本发明结构简单，成本较低，系统性能稳定，医生可以方便地选择多种波长的内窥镜成像，这为一些疾病的早期诊断，特别是早期支气管疾病的诊断提供了有力的诊断依据。2. The present invention has simple structure, low cost and stable system performance. Doctors can conveniently select endoscopic imaging with multiple wavelengths, which provides a powerful diagnostic basis for the early diagnosis of some diseases, especially the diagnosis of early bronchial diseases. .
附图说明Description of drawings
图1为本发明的工作原理示意图。Fig. 1 is a schematic diagram of the working principle of the present invention.
其中，in,
1、主控制器 2、光源单元 21、发光器件 22、滤光器件 23、入射透镜组 24、入射光纤耦合器 3、内窥镜单元 4、检测单元 41、接收光纤耦合器 42、接收透镜组 43、分光器件44、成像器件 5、显示单元 6、云服务器1. Main controller 2, light source unit 21, light emitting device 22, filter device 23, incident lens group 24, incident fiber coupler 3, endoscope unit 4, detection unit 41, receiving fiber coupler 42, receiving lens group 43. Optical splitting device 44, imaging device 5, display unit 6, cloud server
具体实施方式Detailed ways
下面结合附图和具体的实施例对本发明作进一步的详细说明，但本发明并不限于这些实施例。The present invention will be further described in detail below in conjunction with the accompanying drawings and specific embodiments, but the present invention is not limited to these embodiments.
如图1所示，一种用于支气管疾病早期诊断的荧光内窥镜系统，包括主控制器1、光源单元2、内窥镜单元3、检测单元4、云服务器6和显示单元5。所述云服务器6通过互联网与主控制器1相连。所述显示单元5通过USB接口与主控制器1相连。主控制器1通过电缆分别与光源单元2和检测单元4相连接。光源单元2通过入射光纤7与内窥镜单元3相连接。检测单元4通过接收光纤8与内窥镜单元3相连接。As shown in FIG. 1 , a fluorescence endoscope system for early diagnosis of bronchial diseases includes a main controller 1 , a light source unit 2 , an endoscope unit 3 , a detection unit 4 , a cloud server 6 and a display unit 5 . The cloud server 6 is connected with the main controller 1 through the Internet. The display unit 5 is connected to the main controller 1 through a USB interface. The main controller 1 is respectively connected with the light source unit 2 and the detection unit 4 through cables. The light source unit 2 is connected to the endoscope unit 3 through an incident optical fiber 7 . The detection unit 4 is connected to the endoscope unit 3 via a receiving optical fiber 8 .
所述主控制器1用于控制光源单元2、内窥镜单元3和检测单元4。具体的来说，所述主控制器1包括时序控制模块、波段选择模块、同步触发模块、图像采集模块、光谱处理模块和图像处理模块。波段选择模块用于根据需要进行激发光束的波段选择，选择好相应的波段后，主控制器1通过时序控制模块和同步触发模块控制光源单元2和检测单元4同时工作，从而保证了光谱激发与光谱信号采集的同步性。所述图像采集模块用于接收来自检测部分的数据并将数据传输至光谱处理模块、图像处理模块进行数据处理，同时将数据传输至显示单元5进行图像显示。The main controller 1 is used to control the light source unit 2 , the endoscope unit 3 and the detection unit 4 . Specifically, the main controller 1 includes a timing control module, a band selection module, a synchronization trigger module, an image acquisition module, a spectrum processing module and an image processing module. The band selection module is used to select the band of the excitation beam according to the needs. After the corresponding band is selected, the main controller 1 controls the light source unit 2 and the detection unit 4 to work simultaneously through the timing control module and the synchronous trigger module, thus ensuring the spectral excitation and Synchronization of spectral signal acquisition. The image acquisition module is used to receive data from the detection part and transmit the data to the spectrum processing module, the image processing module for data processing, and at the same time transmit the data to the display unit 5 for image display.
所述光源单元2用于发出激发光束并将激发光束传导至内窥镜单元3。具体地来说，所述光源单元2包括依次排布的发光器件21、滤光器件22、入射透镜组23和入射光纤耦合器24。所述发光器件21作为光源发出激发光束。所述发光器件21包括氙灯、卤素灯、激光器或发光二极管。所述滤光器件22用于实现不同波长激发光束的选通，所述滤光器件22包括第一滤光片组、第一声光可调谐滤波器或第一液晶可调谐滤波器。入射透镜组23与入射光纤耦合器24用以将经滤光器件选通得到的激发光束耦合到入射光纤7中并传输至内窥镜单元3。The light source unit 2 is used to emit excitation beams and transmit the excitation beams to the endoscope unit 3 . Specifically, the light source unit 2 includes a light emitting device 21 , a filter device 22 , an incident lens group 23 and an incident fiber coupler 24 arranged in sequence. The light emitting device 21 is used as a light source to emit excitation light beams. The light emitting device 21 includes a xenon lamp, a halogen lamp, a laser or a light emitting diode. The filter device 22 is used for gating the excitation light beams with different wavelengths, and the filter device 22 includes a first filter group, a first acousto-optic tunable filter or a first liquid crystal tunable filter. The incident lens group 23 and the incident fiber coupler 24 are used to couple the excitation beam gated by the filter device into the incident optical fiber 7 and transmit it to the endoscope unit 3 .
所述光源单元2一端连接主控制器1、一端连接内窥镜单元3，发光器件21获取主控制器1的命令进行激发光束的发射与关断，滤光器件22根据主控制器1选择的波段进行相应波段的选通，通过滤光器件22的光束再经入射透镜组23和入射光纤耦合器24将激发光束耦合进入射光纤7，通过入射光纤7将激发光束传输至下述内窥镜。One end of the light source unit 2 is connected to the main controller 1, and the other end is connected to the endoscope unit 3. The light-emitting device 21 obtains the command of the main controller 1 to emit and turn off the excitation beam. The corresponding wavelength band is selected, and the light beam passing through the optical filter device 22 is coupled into the incident optical fiber 7 by the incident lens group 23 and the incident fiber coupler 24, and the excitation beam is transmitted to the following endoscope through the incident optical fiber 7 .
所述内窥镜单元3用于将激发光束导至支气管表面并将支气管表面发出的荧光信号传输至检测单元4。具体地来说，所述内窥镜单元3包括用以进入待检测对象体内采集图像的内窥镜和用以操作内窥镜伸入的操作手柄。通过操纵操作手柄可以调节内窥镜成像的位置与角度，以便找到合适的观察位置。The endoscope unit 3 is used to guide the excitation beam to the surface of the bronchus and transmit the fluorescent signal emitted from the surface of the bronchus to the detection unit 4 . Specifically, the endoscope unit 3 includes an endoscope for entering into the body of the subject to be inspected to collect images and an operating handle for operating the insertion of the endoscope. The position and angle of endoscope imaging can be adjusted by manipulating the operating handle to find a suitable observation position.
所述检测单元4用于对荧光信号进行分光和采集，并将采集到的数据实时传输至主控制器1。具体地来说，所述检测单元4包括依次排布的接收光纤耦合器41、接收透镜组42、分光器件43和成像器件44。所述接收光纤耦合器41和接收透镜组42用于接收和输出来自内窥镜单元3的荧光信号。所述分光器件43用于将传输来的荧光信号进行分光处理。分光器件43包括第二滤光片组、第二声光可调谐滤波器或第二液晶可调谐滤波器。所述成像器件44用于收集经分光处理后的荧光信号并进行图像采集。成像器件44包括电荷耦合元件传感器或互补金属氧化物半导体传感器。The detection unit 4 is used to split and collect the fluorescence signal, and transmit the collected data to the main controller 1 in real time. Specifically, the detection unit 4 includes a receiving fiber coupler 41 , a receiving lens group 42 , a spectroscopic device 43 and an imaging device 44 arranged in sequence. The receiving fiber coupler 41 and the receiving lens group 42 are used to receive and output the fluorescence signal from the endoscope unit 3 . The spectroscopic device 43 is used for spectroscopically processing the transmitted fluorescent signal. The spectroscopic device 43 includes a second filter group, a second acousto-optic tunable filter or a second liquid crystal tunable filter. The imaging device 44 is used to collect the fluorescent signal after spectroscopic processing and perform image acquisition. Imaging device 44 includes a charge-coupled element sensor or a complementary metal-oxide-semiconductor sensor.
从内窥镜输出的荧光信号通过接收光纤耦合器41及接收透镜组42传输至分光器件43，分光器件43根据主控制器1的指令对荧光信号进行拆分，然后通过成像器件44对荧光信号进行采集。The fluorescence signal output from the endoscope is transmitted to the spectroscopic device 43 through the receiving optical fiber coupler 41 and the receiving lens group 42. The spectroscopic device 43 splits the fluorescent signal according to the instructions of the main controller 1, and then the fluorescent signal is analyzed by the imaging device 44. to collect.
通过检测单元4采集来的光谱数据经过主控制器1的处理后传输至云服务器6以进行云存储、数据维护以及云计算。具体地来说，所述云服务器6包括云存储模块、数据维护模块和云计算模块。所述云存储模块由高性能、大容量磁盘阵列构成，云存储模块用于患者诊断数据的可靠存储与高速读取。所述数据维护模块用以实现云存储模块中数据的定时清理、更新以及用以实现不同云服务器6之间的数据共享。所述云计算模块提供强大的荧光光谱成像数据分析功能，用以实现光谱拆分、背景消除和辅助诊断。Spectral data collected by the detection unit 4 is processed by the main controller 1 and then transmitted to the cloud server 6 for cloud storage, data maintenance and cloud computing. Specifically, the cloud server 6 includes a cloud storage module, a data maintenance module and a cloud computing module. The cloud storage module is composed of a high-performance and large-capacity disk array, and the cloud storage module is used for reliable storage and high-speed reading of patient diagnostic data. The data maintenance module is used to realize regular cleaning and updating of data in the cloud storage module and to realize data sharing between different cloud servers 6 . The cloud computing module provides a powerful fluorescence spectrum imaging data analysis function to realize spectrum splitting, background elimination and auxiliary diagnosis.
所述显示单元5包括显示硬件和操作软件，用以实现图像的显示和内窥镜单元的操作控制。所述显示硬件包括台式电脑、笔记本电脑、掌上电脑、平板电脑或智能手机等。The display unit 5 includes display hardware and operating software to realize image display and operation control of the endoscope unit. The display hardware includes a desktop computer, a notebook computer, a palmtop computer, a tablet computer or a smart phone and the like.
使用本发明中的荧光内窥镜进行早期支气管疾病的诊断时，发光器件21发出的光经过滤光器件22对合适波段的光束进行选通，然后通过入射透镜组23与入射光纤耦合器24将选择的波段耦合进入射光纤7，通过入射光纤7将光束传输至内窥镜，并通过内窥镜进入支气管内表面。激发光束对支气管表面进行照射后，组织发射荧光信号，返回的荧光信号通过接收光纤8传输至检测单元4，检测单元4实现了对传回的荧光信号的分光和采集，主控制器1进行数据的分析与上传，与主控制器1相连的显示单元5的操作软件可以控制整个系统的正常运行，主控制器1将检测单元采集到的光谱数据进行分析，并通过互联网传输至云服务器6，通过云服务器6对光谱信号进行云存储、数据维护以及云计算。When using the fluorescent endoscope in the present invention to diagnose early bronchial diseases, the light emitted by the light-emitting device 21 is selected by the light beam of the appropriate wavelength band through the filter device 22, and then passed through the incident lens group 23 and the incident fiber coupler 24. The selected wavelength band is coupled into the incident fiber 7, and the light beam is transmitted to the endoscope through the incident fiber 7, and enters the inner surface of the bronchus through the endoscope. After the excitation beam irradiates the surface of the bronchi, the tissue emits a fluorescent signal, and the returned fluorescent signal is transmitted to the detection unit 4 through the receiving optical fiber 8. analysis and uploading, the operating software of the display unit 5 connected to the main controller 1 can control the normal operation of the entire system, the main controller 1 analyzes the spectral data collected by the detection unit, and transmits it to the cloud server 6 through the Internet, Cloud storage, data maintenance and cloud computing are performed on the spectral signals through the cloud server 6.
本发明中未述及的部分采用或借鉴已有技术即可实现。The parts not mentioned in the present invention can be realized by adopting or referring to the prior art.
此外，术语“第一”、“第二”仅用于描述目的，而不能理解为指示或暗示相对重要性。In addition, the terms "first" and "second" are used for descriptive purposes only, and should not be understood as indicating or implying relative importance.
本文中所描述的具体实施例仅仅是对本发明的精神所作的举例说明。本发明所属技术领域的技术人员可以对所描述的具体实施例做各种各样的修改或补充或采用类似的方式替代，但并不会偏离本发明的精神或者超越所附权利要求书所定义的范围。The specific embodiments described herein are merely illustrative of the spirit of the invention. Those skilled in the art to which the present invention belongs can make various modifications or supplements to the described specific embodiments or adopt similar methods to replace them, but they will not deviate from the spirit of the present invention or go beyond the definition of the appended claims range.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110859585A (en) * | 2019-11-11 | 2020-03-06 | 深圳市中达瑞和科技有限公司 | Hyperspectral endoscopic imaging system |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101125075A (en) * | 2007-09-26 | 2008-02-20 | 叶衍铭 | Fluoroscopic image early cancer diagnosis equipment |
| WO2013002350A1 (en) * | 2011-06-29 | 2013-01-03 | 京都府公立大学法人 | Tumor site identification device and method |
| CN103169446A (en) * | 2013-04-15 | 2013-06-26 | 叶衍铭 | Suspicious early-stage cancer lesion examination device suitable for endoscopy |
| CN103315711A (en) * | 2013-06-26 | 2013-09-25 | 西安电子科技大学 | Medical endoscopic Cherenkov fluorescence imaging system |
| CN104116497A (en) * | 2014-07-22 | 2014-10-29 | 中国科学院自动化研究所 | Endoscopic optical molecular imaging guidance system and multi-spectral imaging method |
| US20150030542A1 (en) * | 2013-07-26 | 2015-01-29 | Sunil Singhal | Methods for medical imaging |
| CN105054890A (en) * | 2015-09-07 | 2015-11-18 | 中国医学科学院生物医学工程研究所 | Tumor tissue detection device based on endoscope |
| CN105852790A (en) * | 2016-04-26 | 2016-08-17 | 郑洪� | Endoscopic device and endoscope |
-
2017
- 2017-09-14 CN CN201710824809.XA patent/CN107550450A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101125075A (en) * | 2007-09-26 | 2008-02-20 | 叶衍铭 | Fluoroscopic image early cancer diagnosis equipment |
| WO2013002350A1 (en) * | 2011-06-29 | 2013-01-03 | 京都府公立大学法人 | Tumor site identification device and method |
| CN103169446A (en) * | 2013-04-15 | 2013-06-26 | 叶衍铭 | Suspicious early-stage cancer lesion examination device suitable for endoscopy |
| CN103315711A (en) * | 2013-06-26 | 2013-09-25 | 西安电子科技大学 | Medical endoscopic Cherenkov fluorescence imaging system |
| US20150030542A1 (en) * | 2013-07-26 | 2015-01-29 | Sunil Singhal | Methods for medical imaging |
| CN104116497A (en) * | 2014-07-22 | 2014-10-29 | 中国科学院自动化研究所 | Endoscopic optical molecular imaging guidance system and multi-spectral imaging method |
| CN105054890A (en) * | 2015-09-07 | 2015-11-18 | 中国医学科学院生物医学工程研究所 | Tumor tissue detection device based on endoscope |
| CN105852790A (en) * | 2016-04-26 | 2016-08-17 | 郑洪� | Endoscopic device and endoscope |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110859585A (en) * | 2019-11-11 | 2020-03-06 | 深圳市中达瑞和科技有限公司 | Hyperspectral endoscopic imaging system |
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