CN107550450A - A kind of fluorescence endoscopy system for bronchial disease early diagnosis - Google Patents
A kind of fluorescence endoscopy system for bronchial disease early diagnosis Download PDFInfo
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Abstract
The invention discloses a kind of fluorescence endoscopy system for bronchial disease early diagnosis, including master controller, light source cell, endoscopic unit, detection unit, Cloud Server and display unit, Cloud Server is connected by internet with master controller, display unit is connected by USB interface with master controller, master controller is connected with light source cell and detection unit respectively by cable, and light source cell and detection unit are connected by optical fiber with endoscopic unit respectively.The present invention realizes the high-resolution to bronchus position, high-precision light spectrum image-forming by spectral imaging technology, while is transmitted image information to Cloud Server by internet, realizes the Real-Time Sharing and auxiliary diagnosis of data.
Description
Technical Field
The invention belongs to the technical field of optical imaging, and particularly relates to a fluorescent endoscope system for early diagnosis of bronchial diseases.
Background
The endoscope technology is one of the indispensable instruments for modern medical diagnosis, can directly observe organs in a human body through the endoscope, and has important significance for early diagnosis of diseases such as bronchus and the like.
Clinical experience shows that early diagnosis of diseases such as bronchi is very important, and fluorescent endoscope technology capable of realizing high-resolution spectral imaging is increasingly gaining attention. The spectral imaging technology is an imaging technology generated by perfectly combining a spectral technology and an optical imaging technology, and is a novel imaging technology developed on the basis of spectral imaging, and the application of detecting, distinguishing and the like of a target object is realized through the change of the light intensity of the target object to a group of light rays with different wavelengths on the basis of the principle that different objects have different absorption differences to the light rays with different wavelengths. In the current clinical research, the multispectral imaging technology is combined with clinical diagnosis, and the multispectral imaging technology and the clinical diagnosis are simultaneously obtained by the microscopic endoscopic imaging technology, so that the detection sensitivity is greatly improved, the biochemical information of a molecular level sample is obtained, and an important basis is provided for the clinical diagnosis of diseases such as cancer, bronchus and the like. The disadvantages of the existing diagnostic techniques are due to the limitations of the performance of the diagnostic equipment on one hand and due to the discrepancy between the subjective judgment error of the doctor and the medical level on the other hand.
CN102697449A discloses a light source device for an endoscope connected to or attached to an endoscope that emits light guided out through a light guide device into a body cavity, the light source device for an endoscope including: a laser light source unit including at least 1 st and 2 nd laser light sources, the 1 st laser light source generating 1 st laser light, the 2 nd laser light source generating 2 nd laser light having a center wavelength different from that of the 1 st laser light; and a wavelength conversion unit configured to receive the 1 st and 2 nd laser beams, convert the 1 st laser beam into a white light, emit illumination light in which the 2 nd laser beam is mixed to the white light, and input the illumination light from the wavelength conversion unit to the light guide device. The device does not allow for the selection of different wavelengths of light.
CN103315711B discloses a medical endoscopic cerenkov luminescence imaging system, said system comprising: the endoscope probe is used for collecting white light signals on the surface of the detected object and/or Cerenkov fluorescence signals emitted by the combination of a target object in the detected object and the probe; one end of the optical fiber image transmission bundle is connected with the endoscope probe and is used for transmitting the white light signal and/or the Cerenkov fluorescence signal; the detection device is connected with the other end of the optical fiber image transmission beam and is used for converting the white light signal and/or the Cerenkov fluorescence signal transmitted by the optical fiber image transmission beam into an electric signal; and the computing and imaging device is connected with the detection device and is used for carrying out subsequent processing on the converted electric signal to obtain a white light structure image on the surface of the detected object and/or a Cerenkov fluorescence image emitted by the combination of the target object in the detected object and the probe. The medical endoscopic Cerenkov luminescence imaging system has the defects of few imaging nuclides, low imaging speed, low light signal intensity and insufficient signal penetrability.
Moreover, in view of the prior art disclosure, there is no device for synchronizing the spectral excitation and the spectral signal acquisition. In addition, the existing spectral endoscopic imaging technology has other defects, such as: the endoscopic imaging system is complex, large in size, high in manufacturing cost and dependent on the experience of medical staff, and the accuracy, stability and imaging precision of the endoscopic imaging system cannot meet the current clinical requirements.
Disclosure of Invention
The invention provides the fluorescence endoscope system for early diagnosis of bronchial diseases, which avoids the defects in the prior art, realizes high-resolution and high-precision spectral imaging of bronchial positions by a spectral imaging technology, and simultaneously transmits image information to a cloud server by the Internet, thereby realizing real-time sharing of data and instrument-assisted diagnosis.
The technical scheme adopted by the invention is as follows:
a fluorescence endoscope system for early diagnosis of bronchial diseases comprises a main controller, a light source unit, an endoscope unit, a detection unit, a cloud server and a display unit, wherein the cloud server is connected with the main controller through the Internet, the display unit is connected with the main controller through a USB interface, the main controller is respectively connected with the light source unit and the detection unit through cables, the light source unit and the detection unit are respectively connected with the endoscope unit through optical fibers, the main controller is used for controlling the light source unit, the endoscope unit and the detection unit, the light source unit is used for emitting an excitation beam and transmitting the excitation beam to the endoscope unit, the endoscope unit is used for guiding the excitation beam to the surface of a bronchus and transmitting a fluorescence signal emitted by the surface of the bronchus to the detection unit, the detection unit is used for splitting and collecting the fluorescence signal and transmitting the collected data to the main controller in real time, the main controller transmits the data transmitted from the detection unit to the cloud server for cloud storage, data maintenance and cloud computing.
The main controller comprises a time sequence control module, a wave band selection module, a synchronous trigger module, an image acquisition module, a spectrum processing module and an image processing module, wherein the wave band selection module is used for selecting wave bands of exciting light beams according to needs, the time sequence control module and the synchronous trigger module are used for controlling the light source unit and the detection unit to work simultaneously, the image acquisition module is used for receiving data from the detection part and transmitting the data to the spectrum processing module and the image processing module for data processing, and meanwhile, the data is transmitted to the display unit for image display.
The light source unit comprises a light emitting device, a filter device, an incident lens group and an incident optical fiber coupler which are sequentially arranged, the light emitting device is used as a light source to emit excitation beams, the filter device is used for gating the excitation beams with different wavelengths, and the incident lens group and the incident optical fiber coupler are used for coupling the excitation beams gated by the filter device to optical fibers used for connecting the light source unit and the endoscope unit and transmitting the excitation beams to the endoscope unit.
The light emitting device comprises a xenon lamp, a halogen lamp, a laser or a light emitting diode; the optical filter device comprises a first optical filter set, a first acousto-optic tunable filter or a first liquid crystal tunable filter.
The endoscope unit comprises an endoscope and an operation handle, wherein the endoscope is used for entering a body of an object to be detected to collect images, and the operation handle is used for operating the endoscope to stretch into the body.
The detection unit comprises a receiving optical fiber coupler, a receiving lens group, a light splitting device and an imaging device which are sequentially arranged, the receiving optical fiber coupler and the receiving lens group are used for receiving and outputting fluorescence signals from the endoscope unit, the light splitting device is used for carrying out light splitting processing on the transmitted fluorescence signals, and the imaging device is used for collecting the fluorescence signals after light splitting processing and carrying out image acquisition.
The light splitting device comprises a second filter set, a second acousto-optic tunable filter or a second liquid crystal tunable filter; the imaging device includes a charge coupled element sensor or a complementary metal oxide semiconductor sensor.
The cloud server comprises a cloud storage module, a data maintenance module and a cloud computing module, the cloud storage module is used for reliably storing and reading the patient diagnosis data at a high speed, the data maintenance module is used for achieving timing cleaning and updating of the data in the cloud storage module and achieving data sharing among different cloud servers, and the cloud computing module is used for achieving spectrum splitting, background elimination and auxiliary diagnosis.
The display unit includes display hardware and operating software to implement the display of images and the operational control of the endoscope unit.
The display hardware comprises a desktop computer, a notebook computer, a palm computer, a tablet computer or a smart phone.
Due to the adoption of the technical scheme, the invention has the beneficial effects that:
1. the invention can realize excitation and emission spectrum real-time imaging, has simple operation and high imaging resolution, and the main controller is externally connected with the cloud server and transmits the image and the fluorescence signal to the cloud server through the network, thereby realizing real-time sharing and auxiliary diagnosis of data and improving the accuracy of judgment.
2. The invention has simple structure, lower cost and stable system performance, and doctors can conveniently select endoscope imaging with various wavelengths, which provides powerful diagnosis basis for early diagnosis of some diseases, especially early diagnosis of bronchial diseases.
Drawings
Fig. 1 is a schematic diagram of the working principle of the present invention.
Wherein,
1. main controller 2, light source unit 21, light emitting device 22, filter device 23, incident lens group 24, incident optical fiber coupler 3, endoscope unit 4, detection unit 41, receiving optical fiber coupler 42, receiving lens group 43, light splitting device 44, imaging device 5, display unit 6, cloud server
Detailed Description
The present invention will be described in further detail with reference to the following drawings and specific examples, but the present invention is not limited to these examples.
As shown in fig. 1, a fluorescence endoscope system for early diagnosis of bronchial diseases includes a main controller 1, a light source unit 2, an endoscope unit 3, a detection unit 4, a cloud server 6, and a display unit 5. The cloud server 6 is connected with the main controller 1 through the internet. The display unit 5 is connected with the main controller 1 through a USB interface. The main controller 1 is connected to the light source unit 2 and the detection unit 4 via cables, respectively. The light source unit 2 is connected to the endoscope unit 3 through an incident optical fiber 7. The detection unit 4 is connected to the endoscope unit 3 via a receiving optical fiber 8.
The main controller 1 is used to control the light source unit 2, the endoscope unit 3, and the detection unit 4. Specifically, the main controller 1 includes a timing control module, a band selection module, a synchronous trigger module, an image acquisition module, a spectrum processing module, and an image processing module. The band selection module is used for selecting the band of the excitation light beam according to the requirement, and after the corresponding band is selected, the main controller 1 controls the light source unit 2 and the detection unit 4 to work simultaneously through the time sequence control module and the synchronous trigger module, so that the synchronism of spectrum excitation and spectrum signal acquisition is ensured. The image acquisition module is used for receiving data from the detection part, transmitting the data to the spectrum processing module and the image processing module for data processing, and transmitting the data to the display unit 5 for image display.
The light source unit 2 is configured to emit an excitation light beam and to conduct the excitation light beam to the endoscope unit 3. Specifically, the light source unit 2 includes a light emitting device 21, a filter device 22, an incident lens group 23, and an incident fiber coupler 24, which are arranged in this order. The light emitting device 21 emits an excitation light beam as a light source. The light emitting device 21 includes a xenon lamp, a halogen lamp, a laser, or a light emitting diode. The optical filter device 22 is used for realizing the gating of the excitation light beams with different wavelengths, and the optical filter device 22 includes a first optical filter set, a first acousto-optic tunable filter or a first liquid crystal tunable filter. The incident lens group 23 and the incident fiber coupler 24 are used to couple the excitation beam gated by the filter device into the incident fiber 7 and transmit the excitation beam to the endoscope unit 3.
One end of the light source unit 2 is connected with the main controller 1, the other end of the light source unit is connected with the endoscope unit 3, the light emitting device 21 obtains a command of the main controller 1 to emit and shut off an excitation beam, the light filtering device 22 conducts gating of a corresponding wave band according to the wave band selected by the main controller 1, the excitation beam is coupled into the incident optical fiber 7 through the light beam of the light filtering device 22 through the incident lens group 23 and the incident optical fiber coupler 24, and the excitation beam is transmitted to the endoscope through the incident optical fiber 7.
The endoscope unit 3 is used for guiding the excitation light beam to the surface of the bronchus and transmitting the fluorescence signal emitted from the surface of the bronchus to the detection unit 4. Specifically, the endoscope unit 3 includes an endoscope for entering a body of an object to be detected to capture an image and an operation handle for operating the endoscope to be inserted. The position and angle of the endoscope image can be adjusted by manipulating the operating handle so as to find a proper observation position.
The detection unit 4 is used for splitting and collecting the fluorescence signal and transmitting the collected data to the main controller 1 in real time. Specifically, the detection unit 4 includes a receiving fiber coupler 41, a receiving lens group 42, a beam splitter 43, and an imaging device 44, which are arranged in this order. The receiving optical fiber coupler 41 and the receiving lens group 42 are used for receiving and outputting the fluorescence signal from the endoscope unit 3. The optical splitter 43 is used for splitting the transmitted fluorescent signal. The spectroscopic device 43 includes a second filter set, a second acousto-optic tunable filter, or a second liquid crystal tunable filter. The imaging device 44 is used for collecting the fluorescence signals after the light splitting process and performing image acquisition. The imaging device 44 comprises a charge coupled element sensor or a complementary metal oxide semiconductor sensor.
The fluorescence signal output from the endoscope is transmitted to the light splitting device 43 through the receiving optical fiber coupler 41 and the receiving lens group 42, the light splitting device 43 splits the fluorescence signal according to the instruction of the main controller 1, and then the fluorescence signal is collected through the imaging device 44.
The spectral data collected by the detection unit 4 is processed by the main controller 1 and then transmitted to the cloud server 6 for cloud storage, data maintenance and cloud computing. Specifically, the cloud server 6 includes a cloud storage module, a data maintenance module, and a cloud computing module. The cloud storage module is composed of a high-performance and high-capacity disk array and is used for reliably storing and reading the patient diagnosis data at a high speed. The data maintenance module is used for realizing the timing cleaning and updating of data in the cloud storage module and the sharing of data among different cloud servers 6. The cloud computing module provides a powerful fluorescence spectrum imaging data analysis function and is used for realizing spectrum splitting, background elimination and auxiliary diagnosis.
The display unit 5 includes display hardware and operation software to realize display of images and operation control of the endoscope unit. The display hardware comprises a desktop computer, a notebook computer, a palm computer, a tablet computer or a smart phone and the like.
When the fluorescence endoscope of the invention is used for diagnosing early bronchial diseases, light emitted by the light emitting device 21 passes through the filter device 22 to gate light beams with proper wave bands, then the selected wave bands are coupled into the incident optical fiber 7 through the incident lens group 23 and the incident optical fiber coupler 24, the light beams are transmitted to the endoscope through the incident optical fiber 7, and the light beams enter the inner surface of the bronchus through the endoscope. After excitation light beam shines the bronchus surface, organize emission fluorescence signal, the fluorescence signal that returns transmits to detecting element 4 through receiving optic fibre 8, detecting element 4 has realized the beam split and the collection to the fluorescence signal who passes back, main control unit 1 carries out the analysis and uploads of data, the normal operating that entire system can be controlled to the display element 5's that links to each other with main control unit 1 operating software, main control unit 1 carries out the analysis with the spectral data that detecting element gathered, and transmit to cloud ware 6 through the internet, carry out cloud storage, data maintenance and cloud through cloud ware 6 to spectral signal.
Parts which are not described in the invention can be realized by adopting or referring to the prior art.
Furthermore, the terms "first" and "second" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
The specific embodiments described herein are merely illustrative of the spirit of the invention. Various modifications or additions may be made to the described embodiments or alternatives may be employed by those skilled in the art without departing from the spirit or ambit of the invention as defined in the appended claims.
Claims (10)
1. A fluorescence endoscope system for early diagnosis of bronchial diseases is characterized by comprising a main controller, a light source unit, an endoscope unit, a detection unit, a cloud server and a display unit, wherein the cloud server is connected with the main controller through the Internet, the display unit is connected with the main controller through a USB interface, the main controller is respectively connected with the light source unit and the detection unit through cables, the light source unit and the detection unit are respectively connected with the endoscope unit through optical fibers, the main controller is used for controlling the light source unit, the endoscope unit and the detection unit, the light source unit is used for emitting an excitation light beam and transmitting the excitation light beam to the endoscope unit, the endoscope unit is used for guiding the excitation light beam to the surface of a bronchus and transmitting a fluorescence signal emitted by the surface of the bronchus to the detection unit, and the detection unit is used for splitting and collecting the fluorescence, and the main controller transmits the data transmitted from the detection unit to a cloud server for cloud storage, data maintenance and cloud computing.
2. The fluorescence endoscope system of claim 1, wherein the main controller comprises a timing control module, a band selection module, a synchronous trigger module, an image acquisition module, a spectrum processing module and an image processing module, the band selection module is used for selecting the band of the excitation beam according to the requirement, the timing control module and the synchronous trigger module are used for controlling the light source unit and the detection unit to work simultaneously, the image acquisition module is used for receiving the data from the detection part, transmitting the data to the spectrum processing module and the image processing module for data processing, and transmitting the data to the display unit for image display.
3. The fluorescence endoscope system of claim 1, wherein the light source unit comprises a light emitting device, a filter device, an incident lens set and an incident fiber coupler, which are sequentially arranged, the light emitting device is used as a light source to emit an excitation beam, the filter device is used to gate the excitation beams with different wavelengths, and the incident lens set and the incident fiber coupler are used to couple the excitation beam gated by the filter device to the fiber connecting the light source unit and the endoscope unit and transmit the excitation beam to the endoscope unit.
4. The fluorescence endoscope system for early diagnosis of bronchial diseases according to claim 3, characterized in that the light emitting device comprises a xenon lamp, a halogen lamp, a laser or a light emitting diode; the optical filter device comprises a first optical filter set, a first acousto-optic tunable filter or a first liquid crystal tunable filter.
5. A fluorescence endoscope system for early diagnosis of bronchial diseases according to claim 1, characterized in that said endoscope unit comprises an endoscope for entering the body of the subject to be examined to collect images and an operation handle for operating the endoscope to be inserted.
6. The fluorescence endoscope system for early diagnosis of bronchial diseases as claimed in claim 1, wherein the detection unit comprises a receiving fiber coupler, a receiving lens set, a light splitting device and an imaging device, which are arranged in sequence, the receiving fiber coupler and the receiving lens set are used for receiving and outputting the fluorescence signal from the endoscope unit, the light splitting device is used for performing light splitting processing on the transmitted fluorescence signal, and the imaging device is used for collecting the fluorescence signal after light splitting processing and performing image acquisition.
7. The fluorescence endoscope system for early diagnosis of bronchial diseases according to claim 6, wherein said spectroscopic device comprises a second filter set, a second acousto-optic tunable filter or a second liquid crystal tunable filter; the imaging device includes a charge coupled element sensor or a complementary metal oxide semiconductor sensor.
8. The fluorescence endoscope system for early diagnosis of bronchial diseases as claimed in claim 1, wherein said cloud server comprises a cloud storage module, a data maintenance module and a cloud computing module, the cloud storage module is used for reliable storage and high-speed reading of patient diagnosis data, the data maintenance module is used for realizing timing cleaning and updating of data in the cloud storage module and for realizing data sharing among different cloud servers, and the cloud computing module is used for realizing spectrum splitting, background elimination and auxiliary diagnosis.
9. The fluorescence endoscope system for early diagnosis of bronchial diseases according to claim 1, wherein said display unit comprises display hardware and operation software for realizing display of images and operation control of the endoscope unit.
10. The fluorescence endoscope system for early diagnosis of bronchial diseases according to claim 9, characterized in that said display hardware comprises a desktop computer, a laptop computer, a palm computer, a tablet computer or a smart phone.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110859585A (en) * | 2019-11-11 | 2020-03-06 | 深圳市中达瑞和科技有限公司 | Hyperspectral endoscopic imaging system |
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Application publication date: 20180109 |