CN202191264U - Endoscope - Google Patents
Endoscope Download PDFInfo
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- CN202191264U CN202191264U CN2011202570660U CN201120257066U CN202191264U CN 202191264 U CN202191264 U CN 202191264U CN 2011202570660 U CN2011202570660 U CN 2011202570660U CN 201120257066 U CN201120257066 U CN 201120257066U CN 202191264 U CN202191264 U CN 202191264U
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- laser
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- endoscope
- confocal scanning
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Abstract
The utility model relates to an endoscope. The structure of the endoscope comprises a light source illumination system, a confocal scanning unit, a coupling lens group, an image transfer fiber, an objective lens, an optical fiber confocal spectrum analyzing system and an image analyzing and re-building system. The laser source provided by the light source illumination system enters the confocal scanning unit, then the laser source is coupled by the coupling lens group which is arranged in the confocal scanning unit to the image transfer fiber and transmitted to the objective lens later, and then the laser source is reflected to a detection sample by the objective lens; the fluorescent light on the detection sample is transmitted to the optical fiber confocal spectrum analyzing system after passing through the objective lens, the image transfer fiber and the confocal scanning unit; and the fluorescent light is re-built by the image analyzing and re-building system which is arranged in a host. The endoscope of the utility model improves the image resolution of bio-images and has the advantages of high image resolution, small physical size of the probe and real-time detection.
Description
Technical field
This utility model belongs to biologic medical apparatus manufacturing technology field, particularly a kind of endoscope of biomedical cell detection technology.
Background technology
In the medical science, the biological tissue section is a kind of important means that is used for diagnosing tumor and surgical effect assessment clinically in modern times.Data show according to statistics, and there are more than one hundred million biological tissue section diagnosis in the whole world every year, and general process is in health, to take out the tissue slice of living with methods such as punctures, does the pathology diagnosis at microscopically then, and each diagnosis needs time a couple of days, and medical treatment cost is higher.
Simultaneously, present X-ray is taken the photograph medical images such as sheet, CT and MRI and is learned a skill and become the conventional means of medical diagnosis on disease, has accelerated Diagnostic Time greatly.Yet in the cancer initial stage, lump is less not obvious, and existing imaging technique is because resolution limit is difficult to realize the early diagnosis of tumor.With the pulmonary cancer diagnosis is example, it is generally acknowledged that conventional CT can't detect the brief summary nodular tumor body less than 1 centimetre.Current research tendency is to realize the detection of millimeter level even submillimeter level tumor body through space of improving existing medical imaging devices and density resolution.The weak point of above-mentioned current techniques is that the equipment physical property is required to improve greatly, and is unfavorable for the universalness of high-performance image documentation equipment.
Co-focusing micro-endoscope is embodying compellent advantage aspect the early diagnosis of cancer, but in clinical practice, still has many problems of needing solution badly.At present, the burnt equipment of the copolymerization of existing 2 companies drops into clinical use, and PENTAX company is integrated into common scope head end with the burnt equipment of copolymerization, makes it become the burnt special-purpose scope of copolymerization.And the burnt probe of the Cellvizio copolymerization of MKT company inserts through the scope duct, can be used in combination with any scope.The accuracy and the sensitivity of the burnt endoscopic diagnosis various diseases of copolymerization have reached certain level, but still can not satisfy actual needs aspect detection resolution and the image reconstruct.
The utility model content
The purpose of this utility model is to overcome the deficiency that above-mentioned prior art exists, and a kind of endoscope of new structure type is provided.The endoscope of this utility model wants to improve the image resolution ratio of biological image, and the image of reconstruct simultaneously more approaches real structure of cell tissue and state.
In order to reach above-mentioned utility model purpose, the technical scheme that this utility model provides is following:
A kind of endoscope; It is characterized in that; The structure of this endoscope includes light-source illuminating system, confocal scanning unit, coupled lens group, image transmission optical fibre, object lens, the burnt spectroscopic analysis system of optical fiber copolymerization and graphical analysis and reconfiguration system; The LASER Light Source that described light-source illuminating system provides enters to the confocal scanning unit, be coupled in the image transmission optical fibre to transfer to object lens through the coupled lens group, again by the object lens outgoing to surveying on the sample; Survey the fluorescence that reflects on the sample and transfer in the burnt spectroscopic analysis system of optical fiber copolymerization through object lens, image transmission optical fibre, confocal scanning unit again, accomplish image reconstruction through graphical analysis in the main frame and reconfiguration system again.
In the endoscope of this utility model; Described light-source illuminating system comprises power supply, laser driver, laser instrument and laser aligner; Described power supply is that the laser driver power supply is sent laser with drive laser, and the laser that sends is through outgoing behind the laser aligner.
In the light-source illuminating system of this utility model endoscope; The laser instrument that said laser driver drives comprises two in first laser instrument and second laser instrument; Be provided with first laser aligner corresponding to first laser instrument, be provided with second laser aligner corresponding to described second laser instrument.
In the endoscope of this utility model, described confocal scanning unit comprises quick galvanometer, galvanometer and battery of lens at a slow speed, and described battery of lens is in quick galvanometer and at a slow speed between the galvanometer.
In the endoscope of this utility model; The burnt spectroscopic analysis system of described optical fiber copolymerization comprises fluorescent optical filter, filter plate switching device and fluorescence signal detection and amplifying device; Sample tissue contains the fluorescent agent that labelling is used; This fluorescent agent produces fluorescence signal under the irradiation of incident laser, this fluorescence signal is surveyed and amplifying device through object lens, image transmission optical fibre, confocal scanning unit, fluorescent optical filter and fluorescence signal, is finally converted into the signal of telecommunication by photo-detector.
In the endoscope of this utility model, described graphical analysis and reconfiguration system are arranged in the main frame, and it is reduced into two dimension or three-dimensional image with the single point signals that the burnt spectroscopic analysis system of optical fiber copolymerization collects, and reappears and is surveyed cells of tissues structure in the sample.
Based on technique scheme, the endoscope of this utility model compared with prior art has following technological merit:
Adopt optical fiber confocal microscopy and image reconstruction technique in this utility model, overcome the shortcoming of prior art confocal scanning micro-endoscope, have image resolution ratio height, probe physical size little, many-sided technical advantage such as can detect in real time.
Description of drawings
Fig. 1 is the system construction drawing of this utility model endoscope.
Fig. 2 is the index path of this utility model endoscope.
The specific embodiment
Below we combine accompanying drawing and concrete embodiment to come further description is done by the endoscope of this utility model, in the hope of understanding its structure and application more cheer and brightly, but can not limit the protection domain of this utility model with this.
The endoscope of this utility model structurally includes light-source illuminating system, confocal scanning unit, coupled lens group, image transmission optical fibre, object lens, the burnt spectroscopic analysis system of optical fiber copolymerization and graphical analysis and reconfiguration system.The light-source illuminating system here is that whole endoscope provides LASER Light Source.Scanning element is coupled into different fiber in image transmission optical fibre with laser beam with different angles according to the Different control signal.And image transmission optical fibre is made up of a lot of optical fiber, and each independent optical fiber is all the same with traditional optical fiber, has the characteristic that passes light, and image transmission optical fibre is used for substituting the light path of parts of traditional, makes whole endoscope have better motility and portability.Object lens then are surface or the organization internals that the imaging beam emitting laser is focused to sample.
In the endoscope of this utility model; The LASER Light Source that described light-source illuminating system provides enters to the confocal scanning unit; Be coupled in the image transmission optical fibre through the coupled lens group; Transfer to object lens through image transmission optical fibre, again by the object lens outgoing to surveying on the sample, survey the fluorescence that reflects on the sample and transfer in the burnt spectroscopic analysis system of optical fiber copolymerization through object lens, image transmission optical fibre, confocal scanning unit again; Accomplish image reconstruction through graphical analysis in the main frame and reconfiguration system again, and then on visual interface, show.
In the endoscope of this utility model; Described light-source illuminating system A comprises power supply, laser driver, laser instrument and laser aligner; Described power supply is that the laser driver power supply is sent laser with drive laser, and the laser that sends is through outgoing behind the laser aligner.
In the endoscope of this utility model, described confocal scanning unit comprises quick galvanometer, galvanometer and the battery of lens between the two at a slow speed.
In the endoscope of this utility model; The burnt spectroscopic analysis system B of described optical fiber copolymerization comprises fluorescent optical filter, switching device of optical fiber and fluorescence signal detection and amplifying device; Survey in the tissue in the sample and be provided with the fluorescent agent that labelling is used, this fluorescent agent produces fluorescence signal under the irradiation of incident laser.This fluorescence signal is surveyed and amplifying device through object lens, image transmission optical fibre, confocal scanning unit, fluorescent optical filter and fluorescence signal, is finally converted into the signal of telecommunication by photo-detector.
In the endoscope of this utility model, described graphical analysis and reconfiguration system are arranged in the main frame, and it is reduced into two dimension or three-dimensional image with the single point signals that the burnt spectroscopic analysis system of optical fiber copolymerization collects, and reappears the cellularity of being surveyed sample inner tissue.
Be directed to the concrete practical structures situation of this utility model, be provided with two laser instrument in the inside of endoscope, this laser instrument sends laser by the laser driver driving and surveys, and laser driver then connects power supply.Can know by Fig. 1 and Fig. 2; The laser instrument that is driven by laser driver in this utility model comprises first laser instrument 1 and second laser instrument 2; Be provided with first laser aligner 3 corresponding to first laser instrument 1, be provided with second laser aligner 4 corresponding to described second laser instrument 2.The laser beam that is sent by first laser instrument 1 is through first laser aligner, 3 collimations; Enter in the confocal scanning unit 7 by 5 reflections of first optical filter then; Simultaneously; Laser beam warp second laser aligner 4 collimations by second laser instrument 2 sends are also entered in the confocal scanning unit 7 by 6 reflections of second optical filter then.
In confocal scanning unit 7, incident laser is earlier through galvanometer 71 reflections fast, then from battery of lens 73 transmissions, is incident at a slow speed on the galvanometer 72, through galvanometer 72 reflections at a slow speed, is incident to then on the coupled lens group 8 again.Incident laser beam is coupled in the simple optical fiber in the imaging beam 9 through coupled lens group 8, through imaging beam 9 transmission, surveys in the sample 11 through being incident to behind the object lens 10 again.
Because be marked with fluorescent agent in advance in the tissue of detection sample, these fluorescent agents produce fluorescence signal under the irradiation of laser.Because of exciting the fluorescence signal that is produced, exploring laser light at first transmits from object lens 10; Pass through the transmission of the optical fiber in the imaging beam 9 then; Again through coupled lens group 8 and confocal scanning unit 7; From second optical filter 6 and 5 transmissions of first optical filter, enter into the burnt spectroscopic analysis system B of optical fiber copolymerization again.
In the burnt analytical system B of optical fiber copolymerization; Incident fluorescence signal is earlier through the 3rd optical filter 12; The fluorescence signal partial reflection here; It is electronic signal that fluorescence signal after the reflection is incident to 16 internal conversions of first photo-detector after through first lens 14, after this electronic signal converts digital signal into through A/D converter 18 again, inputs in synchronous circuit 19 and the main frame 20.Fluorescence signal by 12 transmissions of above-mentioned the 3rd optical filter incides on the 4th optical filter 13; The 4th optical filter 13 is parallel to the 3rd optical filter 12; Be incident to 17 internal conversions of second photo-detector by its reflected fluorescence signal after through second lens 15 and become electronic signal; This electronic signal inputs in synchronous circuit 19 and the main frame 20 after converting digital signal into through A/D converter 18 again.Above-mentioned construction package is all controlled through control circuit 22, and this control circuit 22 connects synchronous circuit 19, A/D converter 18 and power drives 20, and synchronous circuit 19 then connects scanning galvanometer driving 21 and A/D converter 18.
In above-mentioned main frame 20, be provided with described graphical analysis and reconfiguration system 21, this system is reduced into two dimension or three-dimensional image with the single point signals that the burnt spectroscopic analysis system C of optical fiber copolymerization collects, and reappears and is surveyed the cells of tissues structure.It specifically is the pixel 24 of the position signalling of digital signal that feeds back and synchronous circuit being formed a definite position; Can represent with X, Y, Z, I etc.; Pixel 24 set of collecting are kept in the depositor 23 of host computer; Pass through image reconstruction 25 and Flame Image Process 26 then, will handle the back image then and export 27 to being convenient on the user interface 28 that the user sees through image.
The endoscope of this utility model replaces cold light source through LASER Light Source, the fibre bundle images, and the optical texture of autonomous Design under the precondition that improves image resolution, reduces the physical size of object lens termination, to reach the actual requirement of living imaging simultaneously.Flame Image Process can improve the reconstruction quality of image.This utility model adopts the optical fiber confocal microscopy, combines unique image reconstruction technique, has overcome the shortcoming of prior art, has the image resolution ratio height, many-sided advantages such as physical size is little, real-time detection of popping one's head in.
Claims (6)
1. endoscope; It is characterized in that; The structure of this endoscope includes light-source illuminating system, confocal scanning unit, coupled lens group, image transmission optical fibre, object lens, the burnt spectroscopic analysis system of optical fiber copolymerization and graphical analysis and reconfiguration system; The LASER Light Source that described light-source illuminating system provides enters to the confocal scanning unit, be coupled in the image transmission optical fibre to transfer to object lens through the coupled lens group, again by the object lens outgoing to surveying on the sample; Survey the fluorescence that reflects on the sample and transfer in the burnt spectroscopic analysis system of optical fiber copolymerization through object lens, image transmission optical fibre, confocal scanning unit again, accomplish image reconstruction through graphical analysis in the main frame and reconfiguration system again.
2. endoscope according to claim 1; It is characterized in that; Described light-source illuminating system comprises power supply, laser driver, laser instrument and laser aligner, and described power supply is that the laser driver power supply is sent laser with drive laser, and the laser that sends is through outgoing behind the laser aligner.
3. endoscope according to claim 2; It is characterized in that; The laser instrument that said laser driver drives comprises two in first laser instrument and second laser instrument, is provided with first laser aligner corresponding to first laser instrument, is provided with second laser aligner corresponding to described second laser instrument.
4. endoscope according to claim 1 is characterized in that, described confocal scanning unit comprises quick galvanometer, galvanometer and battery of lens at a slow speed, and described battery of lens is in quick galvanometer and at a slow speed between the galvanometer.
5. endoscope according to claim 1; It is characterized in that; The burnt spectroscopic analysis system of described optical fiber copolymerization comprises fluorescent optical filter, filter plate switching device and fluorescence signal detection and amplifying device, and the fluorescent agent of underlined usefulness in the tissue of detection sample produces fluorescence signal under the irradiation of incident laser; This fluorescence signal is surveyed and amplifying device through object lens, image transmission optical fibre, confocal scanning unit, fluorescent optical filter and fluorescence signal, is finally converted into the signal of telecommunication by photo-detector.
6. endoscope according to claim 1; It is characterized in that; Described graphical analysis and reconfiguration system are arranged in the main frame, and it is reduced into two dimension or three-dimensional image with the single point signals that the burnt spectroscopic analysis system of optical fiber copolymerization collects, and reappears and is surveyed cells of tissues structure in the sample.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011202570660U CN202191264U (en) | 2011-07-20 | 2011-07-20 | Endoscope |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011202570660U CN202191264U (en) | 2011-07-20 | 2011-07-20 | Endoscope |
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| Publication Number | Publication Date |
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| CN202191264U true CN202191264U (en) | 2012-04-18 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2011202570660U Expired - Fee Related CN202191264U (en) | 2011-07-20 | 2011-07-20 | Endoscope |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102389288A (en) * | 2011-07-20 | 2012-03-28 | 上海波汇通信科技有限公司 | Confocal laser micro-endoscope |
| CN103134784A (en) * | 2013-02-05 | 2013-06-05 | 华中科技大学 | Optical fiber living body fluorescence excitation spectral imaging device |
| CN103690136A (en) * | 2013-12-11 | 2014-04-02 | 宋伯根 | Intrinsic fluorescence diagnostic endoscope system |
| CN108523819A (en) * | 2018-03-20 | 2018-09-14 | 广东欧谱曼迪科技有限公司 | Survey the fluorescence navigation endoscopic system and laser power automatic adjusting method of light feedback |
-
2011
- 2011-07-20 CN CN2011202570660U patent/CN202191264U/en not_active Expired - Fee Related
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102389288A (en) * | 2011-07-20 | 2012-03-28 | 上海波汇通信科技有限公司 | Confocal laser micro-endoscope |
| CN102389288B (en) * | 2011-07-20 | 2013-05-15 | 上海波汇通信科技有限公司 | Confocal laser micro-endoscope |
| CN103134784A (en) * | 2013-02-05 | 2013-06-05 | 华中科技大学 | Optical fiber living body fluorescence excitation spectral imaging device |
| CN103134784B (en) * | 2013-02-05 | 2015-04-29 | 华中科技大学 | Optical fiber living body fluorescence excitation spectral imaging device |
| CN103690136A (en) * | 2013-12-11 | 2014-04-02 | 宋伯根 | Intrinsic fluorescence diagnostic endoscope system |
| CN103690136B (en) * | 2013-12-11 | 2015-07-29 | 宋伯根 | Intrinsic fluorescence diagnostic endoscope system |
| CN108523819A (en) * | 2018-03-20 | 2018-09-14 | 广东欧谱曼迪科技有限公司 | Survey the fluorescence navigation endoscopic system and laser power automatic adjusting method of light feedback |
| CN108523819B (en) * | 2018-03-20 | 2024-03-22 | 广东欧谱曼迪科技有限公司 | Fluorescent navigation endoscope system with photometric feedback and automatic laser power adjustment method |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee | ||
| CP03 | Change of name, title or address |
Address after: 201204 room 177, No. 203 blue wave road, Zhangjiang hi tech park, Shanghai Patentee after: SHANGHAI BANDWEAVER TECHNOLOGIES CO., LTD. Address before: Shanghai city 201204 Bibo Road, Zhangjiang High Tech Park of Pudong New Area No. 177 Huahong science and Technology Park B District 203 Patentee before: Shanghai Bohui Communication Technology Co., Ltd. |
|
| CP03 | Change of name, title or address | ||
| CP03 | Change of name, title or address |
Address after: Room 103, Building 299, Zhongchen Road, Songjiang District, Shanghai, 20113 Patentee after: Shanghai Bohui Technology Co., Ltd. Address before: Room 203, 177 Bibo Road, Zhangjiang High-tech Park, Shanghai, 20104 Patentee before: Shanghai Bandweaver Technology Co., Ltd. |
|
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120418 Termination date: 20200720 |