CN207636480U - Hyperspectral microimager for interventional tumor diagnosis - Google Patents
Hyperspectral microimager for interventional tumor diagnosis Download PDFInfo
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- CN207636480U CN207636480U CN201721789291.2U CN201721789291U CN207636480U CN 207636480 U CN207636480 U CN 207636480U CN 201721789291 U CN201721789291 U CN 201721789291U CN 207636480 U CN207636480 U CN 207636480U
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Abstract
The utility model relates to a field such as vital medicine, spectral imaging, micro-imaging, intervention diagnosis and treatment technique and image processing technique, concretely relates to can be used to intervention formula tumor diagnosis's hyperspectral microimager. The utility model relates to a hyperspectral microimager which can be used for interventional tumor diagnosis, comprising an active illumination light source system, an optical fiber bundle image transmission system and a hyperspectral microimaging acquisition system; the active illumination light source system comprises a light source, a collimating mirror, a spectroscope and a light transmitting optical fiber; the optical fiber bundle image transmission system comprises an optical fiber image transmission bundle and a micro objective lens; the hyperspectral microimaging acquisition system comprises a microobjective, an entrance slit, a collimation system, a light splitting system, a converging mirror and a detector. The utility model discloses can the normal position, distinguish tumour tissue and normal tissue in the somatic region fast, avoid using the fluorescence contrast agent to the injury of human body, and the diagnosis rate of accuracy is higher.
Description
Technical field
The utility model is related to life medicine, light spectrum image-forming, micro-imaging, intervention Diagnosis Techniques and image processing techniques etc.
A kind of field, and in particular to EO-1 hyperion microscopic imaging apparatus can be used for insertion type diagnosing tumor.
Background technology
Currently, in terms of tumour especially malignant tumour diagnosing cancer of liver, Tissue pathological diagnosis is still goldstandard,
Micro-endoscope, fujinon electronic video endoscope, ultrasonic endoscopic of appearance etc. are more clear image, reduce although can be provided to doctor
The pain of patient, but be difficult to find early lesion only by image, this, which allows for early stage biopsy, has randomness.
Spectral imaging technology be by imaging technique and spectral technique in conjunction with from, can be on very wide continuous spectral coverage to same
One measured object is imaged simultaneously, and each space pixel dispersion is formed tens to hundreds of again while detecting object space characteristics
A wave band is imaged, and to provide spatial-domain information and spectrum domain information, i.e., " collection of illustrative plates ", this cutting edge technology is detectd in military affairs
Examine, resource exploration, natural disaster monitoring, environmental pollution assessment etc. numerous areas have good use, if light spectrum image-forming skill
Art can be applied in medical diagnosis therapy field, it will make diagnostic techniques lead to a leap formula development.
Invention content
The purpose of this utility model is that propose a kind of EO-1 hyperion microscopic imaging apparatus can be used for insertion type diagnosing tumor, it should
EO-1 hyperion microscopic imaging apparatus can distinguish tumor tissues and normal structure in body in situ, rapidly, avoid using fluoroscopic visualization
Injury of the agent to human body, and accuracy rate of diagnosis is higher.
The technical solution that the utility model solves the above problems is：A kind of EO-1 hyperion can be used for insertion type diagnosing tumor is aobvious
Micro- imager, is characterized in that,
It is passed as system and EO-1 hyperion micro-imaging acquisition system including active illumination light-source system, fiber optic bundle；
Active illumination light-source system includes light source, collimating mirror, spectroscope and Optic transmission fiber；
Fiber optic bundle is passed as system includes optical fiber image transmission beam and speck mirror；
EO-1 hyperion micro-imaging acquisition system includes microcobjective, entrance slit, colimated light system, beam splitting system, convergent mirror
And detector；
Collimated light beam is formed after the collimated mirror of light that light source is sent out, collimated light beam reflects through spectroscope and again via micro- object
Mirror is coupled into Optic transmission fiber channel, internal to import illumination light, imports internal illuminating bundle again via speck mirror meeting
Gather on human body deep tissue；Optical fiber image transmission beam is collected by speck mirror and be coupled into the light reflected through tissue first, then
It is imaged at entrance slit through microcobjective and spectroscope, beam splitting system is incident on after colimated light system and is divided, finally
Via on convergent mirror to detector.
It is the basic structure of the utility model above, is based on the basic structure, the utility model is also made following optimization and changed
Into：
Further, above-mentioned beam splitting system includes prism and grating, and the quantity of prism is two, and grating is located at two prisms
Between.
Further, above-mentioned Optic transmission fiber is distributed in the periphery of optical fiber image transmission beam, and arranged in a ring.
Further, the optical fiber inside above-mentioned optical fiber image transmission beam is with hexagonal array.
Further, the outer diameter of above-mentioned optical fiber image transmission beam is 0.85mm.
The advantages of the utility model：
1, the utility model can be used for the EO-1 hyperion microscopic imaging apparatus of insertion type diagnosing tumor, and active illumination light-source system can
Illumination light is imported in inside of human body, is imaged using speck mirror and is arrived the image transmitting of human body deep tissue by optical fiber image transmission beam
In vitro, and further it is coupled by fiber optic bundle and micro-imaging and Hyperspectral imager, it is different to tissue deep to realize
Spend in situ, quick, the online acquisition of profile information.
2, the utility model can be used for the EO-1 hyperion microscopic imaging apparatus of insertion type diagnosing tumor, by microcobjective and EO-1 hyperion
Imaging acquisition system uses Common-path method, makes the entrance slit of beam splitting system and the confocal face of microcobjective, realizes clinical diagnosis
The synchronous acquisition of image and each picture point curve of spectrum in image in the process, meets the needs of real-time diagnosis and analysis.
3, the utility model can be used for the EO-1 hyperion microscopic imaging apparatus of insertion type diagnosing tumor, using prism-grating-prism
Light-dividing principle, prism is comprehensively utilized and the advantages of grating dispersion light splitting technology, to improve spectral resolution and linear
It spends, grating uses body phase holographic transmission formula grating in system, improves diffraction efficiency.
4, the utility model can be used for the EO-1 hyperion microscopic imaging apparatus of insertion type diagnosing tumor, and optical fiber image transmission beam outer diameter is insufficient
1mm, and fiber optic bundle has certain flexibility, therefore can be internal by dedicated conduit importing in conventional intervention diagnosis and treatment,
While not constituting damage to human body, the real-time illumination and imaging of inside of human body deep tissues are realized.
5, the utility model can be used for the EO-1 hyperion microscopic imaging apparatus of insertion type diagnosing tumor, the acquisition of EO-1 hyperion micro-imaging
The service band of system is related to visible light wave range and near infrared band, can acquire the collection of illustrative plates letter of human liver's different depth tissue
Breath is suitable for insertion type diagnosis human body deep tissues especially liver disease tissue, can accurately differentiate lesion by profile information
The developing stage of tissue and normal structure and accurate judgement pathological tissues.
Description of the drawings
Fig. 1 is the fundamental diagram of the utility model；
Fig. 2 is the arrangement schematic diagram of Optic transmission fiber, optical fiber image transmission beam.
Wherein, 1- specks mirror；2- Optic transmission fibers；3- optical fiber image transmission beams；4- microcobjectives；5- light sources；6- collimating mirrors；7- points
Light microscopic；8- entrance slits；9- colimated light systems；10- beam splitting systems；11- convergent mirrors；12- detectors；13- human body deep tissues.
Specific implementation mode
The preferred embodiment of the utility model is illustrated below in conjunction with attached drawing, it should be understood that described herein excellent
It selects embodiment to be only used for describing and explaining the present invention, is not used to limit the utility model.
Referring to Fig. 1, a kind of EO-1 hyperion microscopic imaging apparatus can be used for insertion type diagnosing tumor includes mainly three systems：
Active illumination light-source system, fiber optic bundle are passed as system, EO-1 hyperion micro-imaging acquisition system.Active illumination light-source system includes light
Source 5, collimating mirror 6, spectroscope 7 and Optic transmission fiber 2；Fiber optic bundle is passed as system includes optical fiber image transmission beam 3 and speck mirror 1；EO-1 hyperion
Micro-imaging acquisition system includes microcobjective 4, entrance slit 8, colimated light system 9, beam splitting system 10, convergent mirror 11 and detector
12。
First, collimated light beam is formed after the collimated mirror of light source 5 is sent out light 6, collimated light beam is reflected and passed through through spectroscope 7 again
Optic transmission fiber 2 is coupled by microcobjective head 4, it is internal to import illumination light, import internal illuminating bundle again via
Speck mirror 1 converges on human body deep tissue 13；Light through tissue reflection is collected by speck mirror 1 and is coupled into light first
Fine coherent fiber bundle 3, then it is transmitted into high light spectrum image-forming acquisition system through microcobjective 4 and spectroscope 7.Biological tissue in this process
Picture via speck camera lens 1, optical fiber image transmission beam 3, microcobjective head 4, high light spectrum image-forming acquisition system is finally entered, to realize
Transmission, amplification and spectra collection to vivo biodistribution tissue picture.
The acquisition of biological tissue images and spectrum realized by EO-1 hyperion micro-imaging acquisition system, the system mainly by
Microcobjective 4, entrance slit 8, colimated light system 9, beam splitting system 10, convergent mirror 11 and detector 12 form.Beam splitting system 10 is
Prism-grating-prism system.Microcobjective 4 and 8 confocal face of entrance slit, it is accurate that the light beam through entrance slit 8 is collimated system 9
It after straight, then is divided by beam splitting system 10, convergent mirror 11 focuses to the light beam after light splitting on the target surface of detector 12, and leads to
The mode for crossing built-in scan carries out spacescan to image planes of the object to be measured after object lens, to obtain the spectrum of whole object
Image shows the data cube handling result of subject image-spectrum finally again after map reconstruction and data analysis
Come.The utility model uses the light-dividing principle of prism-grating-prism, comprehensively utilizes the excellent of prism and grating dispersion light splitting technology
Point, to improve spectral resolution and linear degree, grating uses body phase holographic transmission formula grating in system, improves diffraction
Efficiency.The service band of EO-1 hyperion micro-imaging acquisition system is 400nm~1000nm, and spectral resolution is better than 5nm, imaging point
Resolution is better than 13 μm.
Referring to Fig. 2,3 entire outer diameter 0.85mm of optical fiber image transmission beam, 3 internal optical fiber of optical fiber image transmission beam is with hexagonal array, always
30000 are shared, and Optic transmission fiber 2 is distributed in the periphery of optical fiber image transmission beam 3, and it is arranged in a ring.Outside due to optical fiber image transmission beam 3
Diameter is less than 1mm, and fiber optic bundle has certain flexibility, therefore can intervene dedicated conduit importing body in diagnosis and treatment by conventional
It is interior, while not constituting damage to human body, realize the real-time illumination and imaging of inside of human body deep tissues.Speck mirror 1 is to be situated between
Enter one of most important component in formula EO-1 hyperion microscopic imaging apparatus, illumination light for being converged to tissue and being collected by speck mirror 1
Carry out the reflected light of self-organizing, the resolution ratio and visual field of system by speck mirror 1 numerical aperture and amplification factor and fibre optic image transmission
The optical fiber radical and simple optical fiber diameter of beam 3 are determined.
The collection of illustrative plates that various human body deep layer pathological tissues are acquired using the utility model, can establish biological big-sample data
The Hyperspectral imaging feature of inside of human body internal organs tumour, especially liver cancer, cirrhotic nodule etc. is analyzed in library, carries out canceration group
Comparative study of the high spectrum image with pathological diagnosis is knitted, the prediction algorithm of related canceration situation is combined using these data, it can be real
The automatic quick diagnosis of existing live body canceration situation.
Claims (5)
1. a kind of EO-1 hyperion microscopic imaging apparatus can be used for insertion type diagnosing tumor, it is characterised in that：Including active illumination light source
System, fiber optic bundle are passed as system and EO-1 hyperion micro-imaging acquisition system；
Active illumination light-source system includes light source (5), collimating mirror (6), spectroscope (7) and Optic transmission fiber (2)；
Fiber optic bundle is passed as system includes optical fiber image transmission beam (3) and speck mirror (1)；
EO-1 hyperion micro-imaging acquisition system includes microcobjective (4), entrance slit (8), colimated light system (9), beam splitting system
(10), convergent mirror (11) and detector (12)；
The collimated mirror of light (6) that light source (5) is sent out forms collimated light beam afterwards, collimated light beam reflected again through spectroscope (7) and via
Microcobjective (4) is coupled into Optic transmission fiber (2) channel, internal to import illumination light, imports internal illuminating bundle again
It is converged on human body deep tissue (13) via speck mirror (1)；Light through tissue reflection is collected simultaneously by speck mirror (1) first
It is coupled into optical fiber image transmission beam (3), then is imaged at entrance slit (8) through microcobjective (4) and spectroscope (7), by collimation
It is incident on beam splitting system (10) after system (9) to be divided, finally via on convergent mirror (11) to detector (12).
2. a kind of EO-1 hyperion microscopic imaging apparatus can be used for insertion type diagnosing tumor according to claim 1, feature exist
In：The beam splitting system (10) includes prism and grating, and the quantity of prism is two, and grating is located between two prisms.
3. a kind of EO-1 hyperion microscopic imaging apparatus can be used for insertion type diagnosing tumor according to claim 2, feature exist
In：The Optic transmission fiber (2) is distributed in the periphery of optical fiber image transmission beam (3), and arranged in a ring.
4. a kind of EO-1 hyperion microscopic imaging apparatus can be used for insertion type diagnosing tumor according to claim 3, feature exist
In：The internal optical fiber of the optical fiber image transmission beam (3) is with hexagonal array.
5. a kind of EO-1 hyperion microscopic imaging apparatus can be used for insertion type diagnosing tumor according to claim 4, feature exist
In：The outer diameter of the optical fiber image transmission beam (3) is 0.85mm.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201721789291.2U CN207636480U (en) | 2017-12-18 | 2017-12-18 | Hyperspectral microimager for interventional tumor diagnosis |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107957401A (en) * | 2017-12-18 | 2018-04-24 | 中国科学院西安光学精密机械研究所 | Hyperspectral microimager for interventional tumor diagnosis |
| CN116026464A (en) * | 2023-03-29 | 2023-04-28 | 合肥中科红外精密仪器有限公司 | Snapshot type infrared hyperspectral imaging system and method based on splitting mirror |
| CN116509339A (en) * | 2023-07-04 | 2023-08-01 | 台州安奇灵智能科技有限公司 | Low-power Raman spectrum assisted unmarked diffuse reflection hyperspectral imaging system |
-
2017
- 2017-12-18 CN CN201721789291.2U patent/CN207636480U/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107957401A (en) * | 2017-12-18 | 2018-04-24 | 中国科学院西安光学精密机械研究所 | Hyperspectral microimager for interventional tumor diagnosis |
| CN116026464A (en) * | 2023-03-29 | 2023-04-28 | 合肥中科红外精密仪器有限公司 | Snapshot type infrared hyperspectral imaging system and method based on splitting mirror |
| CN116509339A (en) * | 2023-07-04 | 2023-08-01 | 台州安奇灵智能科技有限公司 | Low-power Raman spectrum assisted unmarked diffuse reflection hyperspectral imaging system |
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