CN204120977U - A kind of live body microscopy endoscopic spectrum imaging device - Google Patents
A kind of live body microscopy endoscopic spectrum imaging device Download PDFInfo
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- CN204120977U CN204120977U CN201420402855.2U CN201420402855U CN204120977U CN 204120977 U CN204120977 U CN 204120977U CN 201420402855 U CN201420402855 U CN 201420402855U CN 204120977 U CN204120977 U CN 204120977U
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- dispersive devices
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- sniffer
- live body
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- 238000003384 imaging method Methods 0.000 title claims abstract description 39
- 238000001228 spectrum Methods 0.000 title claims abstract description 19
- 238000000386 microscopy Methods 0.000 title claims abstract description 14
- 239000006185 dispersion Substances 0.000 claims abstract description 17
- 238000012545 processing Methods 0.000 claims abstract description 14
- 230000003287 optical effect Effects 0.000 claims abstract description 12
- 239000013307 optical fiber Substances 0.000 claims abstract description 12
- 239000004973 liquid crystal related substance Substances 0.000 claims abstract description 4
- 239000010409 thin film Substances 0.000 claims abstract description 4
- 239000000203 mixture Substances 0.000 claims description 6
- 210000000056 organ Anatomy 0.000 abstract description 6
- 238000013461 design Methods 0.000 abstract description 2
- 230000007613 environmental effect Effects 0.000 abstract description 2
- 238000009434 installation Methods 0.000 abstract 1
- 238000001514 detection method Methods 0.000 description 8
- 238000003745 diagnosis Methods 0.000 description 8
- 201000010099 disease Diseases 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 206010028980 Neoplasm Diseases 0.000 description 4
- 201000011510 cancer Diseases 0.000 description 4
- 230000003595 spectral effect Effects 0.000 description 3
- 230000002485 urinary effect Effects 0.000 description 3
- 238000001574 biopsy Methods 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- 238000002189 fluorescence spectrum Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000000985 reflectance spectrum Methods 0.000 description 2
- 239000004606 Fillers/Extenders Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000005056 cell body Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 244000144985 peep Species 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
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Abstract
This utility model belongs to optical image technology field, particularly relates to a kind of live body microscopy endoscopic spectrum imaging device.Live body microscopy endoscopic spectrum imaging device described in the utility model, comprises light supply apparatus, light-dividing device, endoscope and image processing device, dispersion means, sniffer and computer installation; Described dispersion means comprises Dispersive Devices and Dispersive Devices controller, and described Dispersive Devices controller controls the gating that Dispersive Devices realizes different wave length signal; Described Dispersive Devices is acousto-optic tunable filter, liquid crystal tunable optical filter or thin film adjustable optical filter.This utility model live body microscopy endoscopic spectrum imaging device, structure is relatively simple, and small volume, uses convenient; The introducing of imaging optical fiber bundle can carry out the imaging of subcellular definition to intracoelomic cavity road organ inner surface, the more important thing is because Dispersive Devices adopts hermetically sealed design, without moving-member, substantially increase the environmental suitability of instrument, make equipment work more stable.
Description
Technical field
This utility model belongs to optical image technology field, particularly relates to a kind of live body microscopy endoscopic spectrum imaging device.
Background technology
Tumor is the major disease of serious threat human health.Nearly 30 years, global cancer (malignant tumor) fall ill number with average annual 3% ~ 5% speed increase, cancer has become one of most important cause of the death of the mankind.It is higher that clinical experience shows more early to cure survival rate to the diagnosis of cancer, so the micro-endoscope technology that can realize close to the high-resolution imaging of biopsy more and more comes into one's own.Traditional formation method, all only has image-forming diagnose can only provide spatial shape information usually.And spectroscopic diagnostics relies on acquisition at the optical radiation signal of certain wavelength to distinguish the information of sample biochemical composition, obtain the curve of spectrum of each each pixel of image, spectroscopic diagnostics can also provide basis for estimation accurately to medical diagnosis on disease.Microscopy endoscopic optical image technology and high light spectrum image-forming technology are combined and the problem being used for studying biology and the medical science focus that to be also of development in recent years new, clinical middle use spectrum change is carried out medical diagnosis on disease and be have also been obtained and use widely simultaneously.Image-forming diagnose is combined with spectroscopic diagnostics, acquisition both same interior endoscope device realizes simultaneously, greatly improve the sensitivity of detection, both the sample morphology information of subcellsular level had been obtained, the sample biochemical composition information of molecular level can be provided again, become accurately one of foundation judging disease.
But spectrum imaging device of the prior art is quite complicated, bulky, involve great expense, and due to stability, resolution, precision and be subject to the requirement that the problems such as surrounding environment influence are often difficult to reach Precise Diagnosis, existing microscopy endoscopic image-forming diagnose and Spectroscopic diagnosis are combined and is difficult to reach ideal effect.
Utility model content
For defect of the prior art, this utility model provides a kind of live body microscopy endoscopic spectrum imaging device, can the image information of convenient accurate acquisition intracoelomic cavity road organ inner surface subcellular definition and the spectral information of nanometer resolution.
Live body microscopy endoscopic spectrum imaging device described in the utility model, comprises light supply apparatus, light-dividing device, endoscope and image processing device, dispersion means, sniffer and computer;
Described light supply apparatus connects light-dividing device, and described light-dividing device is connected with endoscope and image processing device and dispersion means respectively, and described dispersion means is also connected with computer respectively with sniffer, and described sniffer is also connected to computer;
Described dispersion means comprises Dispersive Devices and Dispersive Devices controller, and described Dispersive Devices controller controls the gating that Dispersive Devices realizes different wave length signal; Described Dispersive Devices is acousto-optic turnable filter (Acousto-Optic Tunable Filter is called for short AOTF), liquid crystal tunable optical filter or thin film adjustable optical filter.
Further, described endoscope and image processing device comprises imaging lens, microcobjective and imaging optical fiber bundle; Described imaging lens and microcobjective composition contracting beam device.
Further, described light source is white light source or LASER Light Source; Described light-dividing device is beam splitter or dichroic mirror.
Further, described sniffer is charge coupled cell (Charge-coupled Device is called for short CCD) detector.
This utility model live body microscopy endoscopic spectrum imaging device, structure is relatively simple, and small volume, uses convenient; The introducing of imaging optical fiber bundle can carry out the imaging of subcellular definition to intracoelomic cavity road organ inner surface, the more important thing is because Dispersive Devices adopts hermetically sealed design, without moving-member, substantially increase the environmental suitability of instrument, make equipment work more stable, and along with the significantly raising of precision and resolution, the endoscopic picture information of subcellular definition and the spectral information of nanometer resolution can be obtained, the diagnosis of the every diseases of equipment such as assist digestion that can be strong and urinary system.
Accompanying drawing explanation
Can understanding feature and advantage of the present utility model clearly by reference to accompanying drawing, accompanying drawing is schematic and should not be construed as and carry out any restriction to this utility model, in the accompanying drawings:
Fig. 1 is the structural representation of a kind of microscopy endoscopic spectrum imaging device of this utility model embodiment;
Detailed description of the invention
Now in conjunction with the accompanying drawings and embodiments technical solutions of the utility model are further elaborated.
As shown in Figure 1, the present embodiment endoscopic spectrum imaging device comprises light supply apparatus, light-dividing device, endoscope and image processing device, dispersion means, sniffer and computer.
Described light supply apparatus connects light-dividing device, and described light-dividing device is connected with endoscope and image processing device and dispersion means respectively, and described dispersion means is also connected with computer respectively with sniffer, and described sniffer is also connected to computer;
Described dispersion means comprises Dispersive Devices and Dispersive Devices controller, and described Dispersive Devices controller controls the gating that Dispersive Devices realizes different wave length signal; Described Dispersive Devices is acousto-optic turnable filter, liquid crystal tunable optical filter or thin film adjustable optical filter.
Light supply apparatus is used for providing detecting light beam.Wherein, when realizing reflectance spectrum detection, light supply apparatus can be wide spectrum light source; When realizing fluorescence spectrum detection, light supply apparatus can be LASER Light Source.
Light-dividing device provides two paths; The detecting light beam that one route light supply apparatus exports enters in endoscope and image processing device through light-dividing device; The folded light beam that another road returns from endoscope and image processing device enters dispersion means after light-dividing device.
Wherein, if detect reflectance spectrum, light-dividing device is beam splitter, if detect fluorescence spectrum, light-dividing device is then dichroic mirror.
Endoscope and image processing device comprises imaging lens, microcobjective and imaging optical fiber bundle; Imaging lens and microcobjective composition contracting beam device, for carrying out contracting bundle to the detecting light beam received from light-dividing device, imaging optical fiber bundle is used for the light beam after by contracting bundle and conducts to detection sample, and collects the fluorescence signal or reflected light signal that are returned by detection sample.
Such as, when using the present embodiment live body microscopy endoscopic spectrum imaging device to carry out medical diagnosis on disease, send wide range light beam or laser beam by light supply apparatus, and enter light-dividing device, wide range light beam or laser beam are reflexed to endoscope and image processing device by light-dividing device.Wide range light beam or laser beam contracting bundle are arrived the degree suitable with imaging optical fiber bundle physical size by the contracting beam device of the imaging lens in endoscope and image processing device and microcobjective composition; Microcobjective by wide range light beam or the laser beam focusing front end face to imaging optical fiber bundle, by the conduction of imaging optical fiber bundle by wide range light beam or Laser beam propagation to detection sample place.In actual use, imaging optical fiber bundle enters into the tract organ inner surfacies such as the digested equipment of body or urinary system equipment by the biopsy channel of conventional endoscope.Wide range light beam or laser beam return diffuse signal or fluorescence signal after arriving detection sample, and Returning beam through the collection of imaging optical fiber bundle, then via the collimator and extender of microcobjective and imaging lens, arrives dispersion means through light-dividing device; Dispersive Devices controller in dispersion means controls the wavelength gated nature of Dispersive Devices, wherein Dispersive Devices is acousto-optic turnable filter, the selected different wave length light beam of order passes through, allow that the signal of a wavelength passes through at every turn, the light beam of the logical narrow wave band of band is by focusing on sniffer after Dispersive Devices, sniffer record is by the image of wavelength light beam.
In vivo peep spectrum imaging device by the present embodiment, structure is relatively simple, and easy to use, little by surrounding environment influence, to convenient in the detection of soma's tract organ inner surface at body, testing result is more accurate; Cost is also cheaper.The introducing of imaging optical fiber bundle can carry out the imaging of subcellular definition to intracoelomic cavity road organ inner surface, and the endoscopic picture information of subcellular definition and the spectral information of nanometer resolution can be obtained, the diagnosis of the every diseases of equipment such as assist digestion that can be strong and urinary system.
Although describe embodiment of the present utility model by reference to the accompanying drawings, but those skilled in the art can make various modifications and variations when not departing from spirit and scope of the present utility model, such amendment and modification all fall into by within claims limited range.
Claims (5)
1. a live body microscopy endoscopic spectrum imaging device, is characterized in that, described equipment comprises light supply apparatus, light-dividing device, endoscope and image processing device, dispersion means, sniffer and computer;
Described light supply apparatus connects light-dividing device, and described light-dividing device is connected with endoscope and image processing device and dispersion means respectively, and described dispersion means is also connected with computer respectively with sniffer, and described sniffer is also connected to computer;
Described dispersion means comprises Dispersive Devices and Dispersive Devices controller, and described Dispersive Devices controller controls the gating that Dispersive Devices realizes different wave length signal; Described Dispersive Devices is acousto-optic turnable filter AOTF, liquid crystal tunable optical filter or thin film adjustable optical filter.
2. equipment according to claim 1, it is characterized in that, described endoscope and image processing device comprises imaging lens, microcobjective and imaging optical fiber bundle; Described imaging lens and microcobjective composition contracting beam device.
3. equipment according to claim 2, it is characterized in that, described light source is white light source or LASER Light Source.
4. equipment according to claim 2, it is characterized in that, described light-dividing device is beam splitter or dichroic mirror.
5. equipment according to claim 2, it is characterized in that, described sniffer is charge coupled cell ccd detector.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420402855.2U CN204120977U (en) | 2014-07-21 | 2014-07-21 | A kind of live body microscopy endoscopic spectrum imaging device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420402855.2U CN204120977U (en) | 2014-07-21 | 2014-07-21 | A kind of live body microscopy endoscopic spectrum imaging device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN204120977U true CN204120977U (en) | 2015-01-28 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201420402855.2U Expired - Lifetime CN204120977U (en) | 2014-07-21 | 2014-07-21 | A kind of live body microscopy endoscopic spectrum imaging device |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104068823A (en) * | 2014-07-21 | 2014-10-01 | 中国科学院遥感与数字地球研究所 | In-vivo microendoscopic spectral imaging system |
| CN109044244A (en) * | 2018-07-02 | 2018-12-21 | 上海树突精密仪器有限公司 | Microscope is peeped in one kind is matched with endoscope |
-
2014
- 2014-07-21 CN CN201420402855.2U patent/CN204120977U/en not_active Expired - Lifetime
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104068823A (en) * | 2014-07-21 | 2014-10-01 | 中国科学院遥感与数字地球研究所 | In-vivo microendoscopic spectral imaging system |
| CN104068823B (en) * | 2014-07-21 | 2017-01-11 | 中国科学院遥感与数字地球研究所 | In-vivo microendoscopic spectral imaging system |
| CN109044244A (en) * | 2018-07-02 | 2018-12-21 | 上海树突精密仪器有限公司 | Microscope is peeped in one kind is matched with endoscope |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20231107 Address after: Room 1816, Room 101, 9th Floor, Building 19, Zone 16, No. 188 South Fourth Ring West Road, Fengtai District, Beijing, 100070 Patentee after: Beijing Ruiyi Zhihang Technology Co.,Ltd. Address before: No. 20, Tun Tun Road, Chaoyang District, Beijing, Beijing Patentee before: Aerospace Information Research Institute,Chinese Academy of Sciences Effective date of registration: 20231107 Address after: No. 20, Tun Tun Road, Chaoyang District, Beijing, Beijing Patentee after: Aerospace Information Research Institute,Chinese Academy of Sciences Address before: No. 20, Tun Tun Road, Chaoyang District, Beijing, Beijing Patentee before: Institute of Remote Sensing and Digital Earth, Chinese Academy of Sciences |
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| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20231129 Address after: 100083 No.1 Kehuiqian Street, Chaoyang District, Beijing Patentee after: Feng Yanlong Address before: Room 1816, Room 101, 9th Floor, Building 19, Zone 16, No. 188 South Fourth Ring West Road, Fengtai District, Beijing, 100070 Patentee before: Beijing Ruiyi Zhihang Technology Co.,Ltd. |
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| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20150128 |