CN105054890A - Tumor tissue detection device based on endoscope - Google Patents
Tumor tissue detection device based on endoscope Download PDFInfo
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- CN105054890A CN105054890A CN201510560409.3A CN201510560409A CN105054890A CN 105054890 A CN105054890 A CN 105054890A CN 201510560409 A CN201510560409 A CN 201510560409A CN 105054890 A CN105054890 A CN 105054890A
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Abstract
The invention provides a tumor tissue detection device based on an endoscope. The device comprises a light source, the endoscope, a light splitting device, an imaging device, a spectrograph and a computer. Through the detection device, a multi-band LED light source is organically combined with the endoscope so that white light information of tissue and autofluorescence information and exogenous fluorescence information under different wavebands can be collected by switching wavelengths through the light source, and lesion portions are comprehensively detected. The fluorescence information can be used for analyzing and processing image information and spectrum information which are provided by the computer at the same time through the light splitting device. Sensitivity and specificity of diagnosis are improved, tissue can be quickly, accurately and objectively diagnosed in time before precancerous lesions, diagnosis accuracy is high, and the tumor cure rate is increased. An effective means is provided for quick, non-invasive, objective and accurate diagnosis of in-vivo tissue, and application prospects are good.
Description
Technical field
The present invention relates to a kind of lesion detection device, especially a kind of tumor tissues checkout gear based on endoscope.
Background technology
Cancer is one of disease of current serious threat human health, has become the main cause of human diseases associated death.Defending according to the world organizes recent statistics data to show, and before the year two thousand twenty, global cancer morbidity will increase by 50%, namely will increase 1,500 ten thousand cancer patients newly every year.Moreover, the death toll of cancer also rapidly rises in the whole world, and the whole world in 2007 has 7,600,000 people and dies from cancer, and the year two thousand thirty, this numeral may increase to 13,200,000.And the new cancer patient in the whole world 20% is in China, and the cancer mortality patient of 24% is in China.Current China is dead 5 people often, namely have 1 people to die from cancer; And in 0 ~ 64 years old population, often dead 4 people, namely have 1 people to die from cancer.According to " Chinese tumor statistics annual report " display, the cancer cure rate of current developed country has reached 65% and China only has about 25%.
The cure rate of cancer has inseparable relation with the stage of its discovery, and it is the Main Means improving cancer cure rate that early stage discovery is treated timely.Show according to statistics, the cure rate of early stage thyroid carcinoma reaches 95%, and the cure rate of breast carcinoma of early stage reaches more than 90%, and early gastric cancer, Operation on Esophageal Cancer excision latter 5 years survival rates reach more than 90%.As long as find that early diagnosis, can extend the life span of patient, improve the quality of living in time.
At present, the application of endoscope can carry out visual inspection to the canceration of tissue inside, improve the level of the diagnosis to in-vivo tumour tissue, but due to the restriction of the technical merits such as resolution, the microtissue pathological changes making conventional endoscope cannot screen naked eyes in body can not to identify.But examination accurately can go out the canceration of microtissue but due to the wavelength of entrained light source and the restriction of photosensitizer, the very right disease of institute is more single with the endoscope of fluorescence diagnosis, cannot diagnose the precancerous lesion organized.Such as, the generation of hepatocarcinoma generally will experience hepatitis, liver cirrhosis and hepatocarcinoma these three, can be diagnosed in time, accurately when traditional fluorescence diagnosis endoscope only develops into hepatocarcinoma.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of tumor tissues checkout gear based on endoscope.
For solving the problems of the technologies described above, technical scheme of the present invention is:
Based on a tumor tissues checkout gear for endoscope, comprise light source, endoscope, light-dividing device, imaging device, spectrogrph and computer, wherein,
Light source is LED alternative light source;
Endoscope, primarily of object lens, post mirror, eyepiece and optical interface composition, the optical interface of described endoscope is connected with described light source by optical cable; Described post mirror is endoscope main body, the front end of described post mirror is provided with object lens, described object lens are primarily of mirror chamber and the optical fiber composition for conducting LED light, described optical fiber is uniformly distributed in around mirror chamber, this optical fiber one end is connected with optical interface, the end of described post mirror is provided with eyepiece, and optical interface is arranged at the front end of described eyepiece;
Light-dividing device, its front end, mirror chamber is provided with handle, and this handle front end is connected for gathering optical information by C type bayonet socket with the eyepiece end of described endoscope; Its mirror chamber end is connected with imaging device with spectrogrph respectively, for gathering spectral information and image information; Its mirror intracavity portion is disposed with wheel disc, collimating mirror, spectroscope and the bonder for being carried out being coupled by the fluorescence of broad band by front end to rear end, described bonder is positioned at spectroscope for gathering the reflection end of spectral information, described wheel disc stud with full impregnated mirror and organize filter plate more, optical filter is used for the interference of filtering exciting light;
Imaging device, is connected with transmissive portion spectroscopical in light-dividing device, for gathering image information;
Spectrogrph, is connected with reflecting part spectroscopical in light-dividing device, for gathering spectral information;
Computer, respectively with light source, light-dividing device, spectrogrph and imaging device connection, for the selection of the switch and wavelength that control light source, the choosing controlling light-dividing device wheel disc turns; For analyzing and processing spectral information and image information, final result is shown over the display.
Preferably, the above-mentioned tumor tissues checkout gear based on endoscope, also comprise filtering apparatus, described filtering apparatus is arranged between light source and optical interface, described filtering apparatus comprises high-pass filter wheel disc group and low pass filter wheel disc group, described high-pass filter wheel disc group is made up of high-pass filter and the first full impregnated mirror, and described low pass filter wheel disc group is made up of low pass filter and the second full impregnated mirror.
Preferably, the above-mentioned tumor tissues checkout gear based on endoscope, described LED alternative light source comprises a white light.
Preferably, the above-mentioned tumor tissues checkout gear based on endoscope, described endoscope is rigid endoscope.
Preferably, the above-mentioned tumor tissues checkout gear based on endoscope, in described light-dividing device, wheel disc studs with a full impregnated mirror and six groups of filter plates.
Preferably, the above-mentioned tumor tissues checkout gear based on endoscope, described imaging device is CCD photographic head.
Preferably, the above-mentioned tumor tissues checkout gear based on endoscope, described bonder is the device that the fluorescence of broad band can be carried out being coupled, condenser lens primarily of 2 groups of collimating lens and 2 groups of different curvature forms, wherein, described 2 groups of collimating lens are arranged at before the condenser lens of 2 groups of different curvature, can be coupled then carry out spectrum analysis to the fluorescence of broad band.
The invention has the beneficial effects as follows:
The above-mentioned tumor tissues checkout gear based on endoscope, adopt multiband LED as excitation source, by can gather the autofluorescence information being organized in different-waveband to the selection of LED wave band, the external fluorescence information of tissue can be gathered in conjunction with photosensitizer, conventional endoscope is made to have the function of fluorescence diagnosis, install light-dividing device additional at the eyepiece position of endoscope simultaneously, image information and the spectral information of lesions position can be gathered like this by the mirror chamber of endoscope simultaneously, then data are sent in computer and carry out processing and final result is shown in the display.
Visible, multiband LED light source and endoscope combine by this checkout gear, can by the white light information of light source to the switching collection tissue of wavelength, autofluorescence information under different-waveband and external fluorescence information, comprehensive detection is carried out to lesions position, fluorescence information is through light-dividing device, can simultaneously for computer provides image information and spectral information to carry out treatment and analysis, improve the Sensitivity and Specificity of diagnosis, can carry out fast to the precancerous lesion of tissue, accurately, diagnose in time and objectively, the accuracy rate of diagnosis is high, add tumor cure rate, quick for biological tissue, noinvasive, objective and diagnosis accurately provides effective way, have a good application prospect.
Accompanying drawing explanation
Fig. 1 is the syndeton schematic diagram of a kind of tumor tissues checkout gear based on endoscope provided by the invention;
Fig. 2 is the light-dividing device internal structure schematic diagram of a kind of tumor tissues checkout gear based on endoscope provided by the invention.
In figure: 1-object lens 2-post mirror 3-optical interface 4-eyepiece
5-(light-dividing device) handle 6-spectroscope 7-bonder 8-spectrogrph
9-CCD photographic head (imaging device) 10-computer
11-light source 12-collimating mirror 13-filtering apparatus
Detailed description of the invention
In order to make those skilled in the art better understand technical scheme of the present invention, below in conjunction with the drawings and the specific embodiments, technical scheme of the present invention is described in further detail.
As shown in Figure 1, the described tumor tissues checkout gear based on endoscope,
Based on a tumor tissues checkout gear for endoscope, comprise light source 11, filtering apparatus 13, endoscope, light-dividing device, imaging device, spectrogrph and computer 10, wherein,
Light source, be LED alternative light source, this LED alternative light source comprises a white light;
Rigid endoscope, forms primarily of object lens 1, post mirror 2, eyepiece 4 and optical interface 3, and the optical interface of described endoscope is connected with described light source by optical cable; Described post mirror is endoscope main body, the front end of described post mirror is provided with object lens, described object lens are primarily of mirror chamber and the optical fiber composition for conducting LED light, described optical fiber is uniformly distributed in around mirror chamber, this optical fiber one end is connected with optical interface, the end of described post mirror is provided with eyepiece, and optical interface is arranged at the front end of described eyepiece;
Filtering apparatus, be arranged between light source and optical interface, described filtering apparatus comprises high-pass filter wheel disc group and low pass filter wheel disc group, described high-pass filter wheel disc group is made up of high-pass filter and the first full impregnated mirror, described low pass filter wheel disc group is made up of low pass filter and the second full impregnated mirror, when light source sends non-white light first after high-pass filter wheel disc again through low pass filter wheel disc, realize narrow band light and excite;
Light-dividing device, its front end, mirror chamber is provided with handle 5, and this handle front end is connected for gathering optical information by C type bayonet socket with the eyepiece end of described endoscope, its mirror chamber end is connected with imaging device 9 with spectrogrph 8 respectively, for gathering spectral information and image information, its mirror intracavity portion is disposed with wheel disc by front end to rear end, collimating mirror 12, spectroscope 6 and the bonder 7 for the fluorescence of broad band is carried out being coupled, described bonder is the device that the fluorescence of broad band can be carried out being coupled, condenser lens primarily of 2 groups of collimating lens and 2 groups of different curvature forms, wherein, described 2 groups of collimating lens are arranged at before the condenser lens of 2 groups of different curvature, can be coupled to the fluorescence of broad band and then carry out spectrum analysis, described bonder is positioned at spectroscope for gathering the reflection end of spectral information, described wheel disc studs with full impregnated mirror and six groups of filter plates (optical filter is used for the interference of filtering exciting light), as shown in Figure 2, incident illumination is irradiated on spectroscope after collimating mirror, wherein the light of reflecting part is changed into spectral information through bonder by spectrometer collection, in described bonder application process, fluorescence enters through entrance port after bonder and first collimates through 2 groups of collimating lens, then through condenser lens that 2 suite rates are different, reach the object that broad band fluorescence is coupled, finally send fluorescence to spectrogrph from exit portal, the light of transmissive portion is changed into image information through collimating mirror by CCD camera collection, specifically, when gathering white light information, wheel disc is pushed full impregnated mirror end, when gathering fluorescence information, wheel disc is pushed corresponding filter plate end with the interference of filtering exciting light noise, and the optical information collected by mirror chamber is divided into spectral information and image information two parts, in operating process, spectroscope is that semi-transparent semi-reflecting lens directional light is irradiated on spectroscope, the mirror reflection that is split demonstrates spectral information after bonder and spectrogrph on host computer, another part is imaged device CCD photographic head through spectroscope and is received on host computer and demonstrates image information after collimating lens,
CCD photographic head (imaging device), (spectroscope is semi-transparent semi-reflecting lens with transmissive portion spectroscopical in light-dividing device, transmissive portion refers to the part of direct transmissive in illumination to spectroscope, the reflecting part hereafter mentioned be split mirror reflection light) be connected, for gathering image information;
Spectrogrph, is connected, for gathering spectral information with reflecting part spectroscopical in light-dividing device (spectroscope is semi-transparent semi-reflecting lens, and reflecting part refers to the part that illumination to spectroscope is reflected back);
Computer, respectively with light source, light-dividing device, spectrogrph and imaging device connection, for the selection of the switch and wavelength that control light source, the choosing controlling light-dividing device wheel disc turns; For analyzing and processing spectral information and image information, final result is shown over the display.
Above-mentioned reference detailed description of the invention is to this kind of detailed description of carrying out based on the tumor tissues checkout gear of endoscope; illustrative instead of determinate; several embodiments can be listed according to institute's limited range; therefore in the change do not departed under general plotting of the present invention and amendment, should belong within protection scope of the present invention.
Claims (7)
1. based on a tumor tissues checkout gear for endoscope, it is characterized in that: comprise light source, endoscope, light-dividing device, imaging device, spectrogrph and computer, wherein,
Light source is LED alternative light source;
Endoscope, primarily of object lens, post mirror, eyepiece and optical interface composition, the optical interface of described endoscope is connected with described light source by optical cable; Described post mirror is endoscope main body, the front end of described post mirror is provided with object lens, described object lens are primarily of mirror chamber and the optical fiber composition for conducting LED light, described optical fiber is uniformly distributed in around mirror chamber, this optical fiber one end is connected with optical interface, the end of described post mirror is provided with eyepiece, and optical interface is arranged at the front end of described eyepiece;
Light-dividing device, its front end, mirror chamber is provided with handle, and this handle front end is connected for gathering optical information by C type bayonet socket with the eyepiece end of described endoscope; Its mirror chamber end is connected with imaging device with spectrogrph respectively, for gathering spectral information and image information; Its mirror intracavity portion is disposed with wheel disc, collimating mirror, spectroscope and the bonder for being carried out being coupled by the fluorescence of broad band by front end to rear end, described bonder is positioned at spectroscope for gathering the reflection end of spectral information, described wheel disc studs with full impregnated mirror and organizes filter plate more;
Imaging device, is connected with transmissive portion spectroscopical in light-dividing device, for gathering image information;
Spectrogrph, is connected with reflecting part spectroscopical in light-dividing device, for gathering spectral information;
Computer, respectively with light source, light-dividing device, spectrogrph and imaging device connection, for the selection of the switch and wavelength that control light source, the choosing controlling light-dividing device wheel disc turns; For analyzing and processing spectral information and image information, final result is shown over the display.
2. the tumor tissues checkout gear based on endoscope according to claim 1, it is characterized in that: also comprise filtering apparatus, described filtering apparatus is arranged between light source and optical interface, described filtering apparatus comprises high-pass filter wheel disc group and low pass filter wheel disc group, described high-pass filter wheel disc group is made up of high-pass filter and the first full impregnated mirror, and described low pass filter wheel disc group is made up of low pass filter and the second full impregnated mirror.
3. the tumor tissues checkout gear based on endoscope according to claim 1, is characterized in that: described LED alternative light source comprises a white light.
4. the tumor tissues checkout gear based on endoscope according to claim 1, is characterized in that: described endoscope is rigid endoscope.
5. the tumor tissues checkout gear based on endoscope according to claim 1, is characterized in that: in described light-dividing device, wheel disc studs with a full impregnated mirror and six groups of filter plates.
6. the tumor tissues checkout gear based on endoscope according to claim 1, is characterized in that: described imaging device is CCD photographic head.
7. the tumor tissues checkout gear based on endoscope according to claim 1, it is characterized in that: described bonder is the device that the fluorescence of broad band can be carried out being coupled, condenser lens primarily of 2 groups of collimating lens and 2 groups of different curvature forms, wherein, described 2 groups of collimating lens are arranged at before the condenser lens of 2 groups of different curvature, be coupled then carry out spectrum analysis to the fluorescence of broad band.
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Cited By (5)
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| CN106913304A (en) * | 2015-12-28 | 2017-07-04 | 北京威斯顿亚太光电仪器有限公司 | A kind of spectrum rigid pipe endoscope system |
| CN107550450A (en) * | 2017-09-14 | 2018-01-09 | 中国科学院高能物理研究所 | A kind of fluorescence endoscopy system for bronchial disease early diagnosis |
| CN110582225A (en) * | 2017-05-02 | 2019-12-17 | 爱尔康公司 | Reconfigurable Optical Coherence Tomography (OCT) system |
| CN113080830A (en) * | 2021-04-07 | 2021-07-09 | 哈尔滨医科大学 | Multi-scale detection device for tumors in gastrointestinal endoscope images |
| CN113261911A (en) * | 2021-05-14 | 2021-08-17 | 天津工业大学 | Fluorescent electronic endoscope imaging system and detection method thereof |
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Application publication date: 20151118 |