CN103315711A - Medical endoscopic Cherenkov fluorescence imaging system - Google Patents
Medical endoscopic Cherenkov fluorescence imaging system Download PDFInfo
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- CN103315711A CN103315711A CN2013102615487A CN201310261548A CN103315711A CN 103315711 A CN103315711 A CN 103315711A CN 2013102615487 A CN2013102615487 A CN 2013102615487A CN 201310261548 A CN201310261548 A CN 201310261548A CN 103315711 A CN103315711 A CN 103315711A
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- 101100117236 Drosophila melanogaster speck gene Proteins 0.000 claims description 15
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Abstract
The invention discloses a medical endoscopic Cherenkov fluorescence imaging system which is characterized by comprising an endoscope probe, an optical fiber image transmission bundle, a detection device and a computing and imaging device; one end of the optical fiber image transmission bundle is connected with the endoscope probe, the other end of the optical fiber image transmission bundle is connected with the detection device; the computing and imaging device is connected with the detection device. The medical endoscopic Cherenkov fluorescence imaging system expands diagnosis range of an endoscope and improves diagnosis precision and early diagnosis capacity of the endoscope, can be used for any endoscopic systems with standard biopsy channels, is easy, flexible and convenient to operate and easy to control, and accordingly has widespread application prospect.
Description
Technical field
The present invention relates to the medical imaging technology field, be specifically related to a kind of medical through Cherenkov's fluorescence imaging system of endoscope of optical molecular imaging technical field, this system can be applicable to clinical early structure and the molecular specificity imaging of the chamber class tissue diseases such as gastroenteric tumor.
Background technology
As a kind of emerging optical molecular image technology, Cherenkov's fluorescence imaging is based on Cherenkov's phenomenon, carries out imaging by survey visible light and the near infrared light that some radionuclide produces in the nuclear decay process.Because existing a large amount of nucleic probes is applied to the clinically Clinics and Practices of various diseases by Food and Drug Administration's approval, therefore will provide new approaches for the molecular probe limitation problem that the clinical Transformation Application of optical molecular image technology faces.Endoscopy refers to by external detecting instrument be sent in the body through human body natural's tract, then the technology that deep layer disease in the body is detected through row, the optical signalling tissue penetration limitation problem that faces for the clinical Transformation Application of optical molecular image technology provides effective solution.
Olympus Co., Ltd is at its practical new patent application documents " endoscope-use insertion unit and endoscopic system ", number of patent application 200620012071.4 provides a kind of and can be have easily inserted endoscope in the body cavity of large intestine etc., do not disclose and cause suffering, can improve endoscope insertion part to endoceliac insertion to the patient among the applying date 2006-4-5.But the structural change of internal organs inner chamber lesion tissue can only detect in the endoscope of this class routine, and function that can not the earlier detection pathological changes and the variation of molecular level are difficult to be applied to internal organs inner chamber tissue disease, such as the early diagnosis of gastroenteropathy.
For the early function that detects internal organs inner chamber tissue disease and the variation of molecular level, research worker has proposed Endoscopy is combined with the molecular image technology, such as the inner peeping type photoacoustic imaging system, referring to Yi Yuan, " Preclinical photoacoustic imaging endoscope based on acousto-optic coaxial system using ring transducer; " Optics Letters, 35,2266-2268 (2010) (Yuan Yi, pre-clinical photoacoustic imaging endoscope based on the optoacoustic coaxial system that adopts loop sensor, optics letter, 35,2266-2268(2010)); Inner peeping type near-infrared optical 3-D imaging system, referring to DaqingPiao, " Endoscopic, rapid near-infrared optical tomography, " Optics Letters, 31,2876-2878 (2006) (Piao Daqing, the quick near-infrared optical fault imaging of inner peeping type, optics letter, 31,2876-2878(2006));In addition, Korea Electrician Tech Research Inst and wheat enlightening Mil company are at its patent application document " fluorescence endoscopic lens device and use this device method to imaging of tissue in health ", number of patent application 02146866.4, a kind of fluorescence endoscopic lens device has been proposed among the applying date 2002-10-16 and use this device in health to the method for imaging of tissue, can improve the degree of accuracy of disease examination.The variation of pathological changes function and molecular level can detect in the endoscope of this class fusion molecule image technology, realizes the early diagnosis of internal organs inner chamber tissue disease, but because the limitation of molecular probe is difficult to carry out clinical Transformation Application.
Clinical Transformation Application for the endoscope that advances the fusion molecule image technology, research worker combines Cherenkov's Imaging-PAM with endoscope, a kind of inner peeping type Cherenkov fluorescence imaging system has been proposed, referring to Sri-RajasekharKothapalli, " Endoscopic imaging of Cerenkov luminescence; " Biomedical Optics Express, 3 (6), 1215-1225 (2012) (Sri-RajasekharKothapalli, inner peeping type Cherenkov fluorescence imaging, the Photobiology wall bulletin, 3(6), 1215-1225(2012)); This system utilizes fibre opic endoscope and highly sensitive CCD camera, gathers Cherenkov's fluorescence signal of organism body surface.Yet this inner peeping type Cherenkov fluorescence imaging system can not provide the White-light image of organism body surface, can't locate the accurate location of pathological changes; In addition, clinically for different diagnosis positions, employed endoscope kind is not identical yet, so this inner peeping type Cherenkov fluorescence imaging system does not have versatility.
Summary of the invention
The objective of the invention is to solve the deficiency that exists in the above-mentioned technology, a kind of can use in flexible-pipe endoscope medical through Cherenkov's fluorescence imaging system of endoscope is provided, white light structural images by gathering the detected object surface and inner targeting target be combined the Cherenkov's fluoroscopic image that sends with probe, two-dimensional position and the distributed intelligence of acquisition detected object inside targeting target.
To achieve these goals, the technical solution used in the present invention is as follows:
A kind of medical through Cherenkov's fluorescence imaging system of endoscope, described system comprises:
Endoscope probe be used for to gather the inner targeting target of detected object surface white light signal and/or detected object and is combined the Cherenkov's fluorescence signal that sends with probe;
Optical fiber image transmission beam, an end is connected with described endoscope probe, is used for transmitting described white light signal and/or described Cherenkov's fluorescence signal;
Sniffer is connected with the described optical fiber image transmission beam other end, is used for described white light signal and/or the Cherenkov's fluorescence signal that transmits through optical fiber image transmission beam is converted into the signal of telecommunication;
Calculate and imaging device, be connected with described sniffer, be used for the signal of telecommunication after the described conversion is carried out subsequent treatment, obtain the white light structural images on detected object surface and/or the inner targeting target of detected object and be combined the Cherenkov's fluoroscopic image that sends with probe.
Need to prove, described endoscope probe comprises the speck mirror, GRIN Lens, and transparent sheath, wherein, described speck mirror is collected detected object surface white light signal and/or Cherenkov's fluorescence signal, and forms the photon light beam of multi-beam collimation, and it is intrafascicular that described photon light beam focuses on described imaging fiber through described GRIN Lens; Described speck mirror and GRIN Lens are arranged in the described transparent sheath.
Need to prove, described sniffer comprises the coupled lens that sets gradually, imaging len, and planar array detector, wherein, described coupled lens is converted into multi-path parallel light with detected object surface white light signal and/or Cherenkov's fluorescence signal, focuses to the sensitive area of described planar array detector through described imaging len, by described planar array detector optical signal is converted into electric signal transmission to described calculating and imaging device again.
Need to prove, described calculating and imaging device comprise image pick-up card, and connected computer, and wherein, described planar array detector is connected with image pick-up card.
As a kind of preferred scheme, described planar array detector is CCD camera or CMOS camera.
Need to prove, described endoscope distal end is provided with four through holes, is respectively illumination channel, and CCD imaging device and activity detect mouth, and wherein, described endoscope probe is arranged at described activity and detects mouth.
A kind of medical method through the Cherenkov of endoscope fluorescence imaging system imaging said method comprising the steps of:
(1a) gather White-light image, the illumination channel by the setting of medical alimentary tract endoscope front end provides background illumination, then utilizes the white light signal on endoscope probe acquisition target surface;
(1b) endoscope probe receives white light signal, forms the photon light beam of multi-beam collimation by the speck mirror, and it is intrafascicular that described photon light beam focuses on described imaging fiber through described GRIN Lens;
(1c) described photon light beam transfers to described sniffer by described imaging fiber bundle;
(1d) coupled lens in the described sniffer is converted into multi-path parallel light with described photon light beam, focus to the sensitive area of described planar array detector through described imaging len, by described planar array detector optical signal is converted into electric signal transmission to described calculating and imaging device again, obtains the White-light image on acquisition target surface;
(2a) gather Cherenkov's fluoroscopic image, close the illumination channel of medical alimentary tract endoscope front end, then utilize the endoscope probe collection because Cherenkov's fluorescence signal that the decay of targeting probe nuclei element emits in the object;
(2b) endoscope probe receives Cherenkov's fluorescence signal, forms the photon light beam of multi-beam collimation by the speck mirror, and it is intrafascicular that described photon light beam focuses on described imaging fiber through described GRIN Lens;
(2c) described photon light beam transfers to described sniffer by described imaging fiber bundle;
(2d) coupled lens in the described sniffer is converted into multi-path parallel light with described photon light beam, focus to the sensitive area of described planar array detector through described imaging len, by described planar array detector optical signal is converted into electric signal transmission to described calculating and imaging device again, obtains Cherenkov's fluoroscopic image on acquisition target surface.
(3) image denoising and fusion, wherein, White-light image and Cherenkov's fluoroscopic image on the surface that step (1a) and step (2a) are collected carry out image denoising and fusion treatment to its image on computers, obtain fusion image;
(4) obtain position and the distributed intelligence of pathological changes, wherein, based on the fusion image that step (3) obtains, can obtain in the acquisition target targeting probe corresponding to its surperficial two-dimensional position information and distributed intelligence.
Beneficial effect of the present invention is:
1, two-fold diagnosis.Both can observe directly by medical endoscope the pathological structure metamorphosis on detected object surface, the variation of the inner pathological changes function of detected object and molecular level be can obtain again, and then two-dimensional position information and the distributed intelligence of the inner targeted probes of detected object obtained.Therefore expand the diagnostic area of endoscope, improved diagnostic accuracy and the early diagnosis ability of endoscope;
2, highly versatile.Since of the present invention medical through the use that can combine with conventional endoscope of Cherenkov's fluorescence imaging system of endoscope, do not need specific endoscope carrier.This system can be used for any Cherenkov's fluorescence imaging that possesses the endoscopic system of standard biopsy passage and have very strong versatility;
3, simple to operate, flexible, convenient.During disease, operator and assistant and other staff can both carry out various operations under the help of monitor in diagnosis and treatment in endoscope, make the operator of each side can both tacit cooperation and safety.Thereby operate flexibly, conveniently, be easy to grasp.
Description of drawings
Fig. 1 is to be the framework schematic diagram of structure of the present invention;
Fig. 2 is further structural principle schematic diagram among Fig. 1;
Fig. 3 is that the present invention cooperates medical alimentary tract endoscope schematic diagram;
Fig. 4 is the flow chart of imaging system using method of the present invention.
The specific embodiment
In order to make purpose of the present invention, technical scheme and advantage clearer, below in conjunction with drawings and Examples, the present invention is further elaborated.Specific embodiment described herein only is used for explaining the present invention, is not for limiting the present invention.
As shown in Figure 1 and Figure 2, the present invention is a kind of medical through Cherenkov's fluorescence imaging system of endoscope, and described system comprises:
Optical fiber image transmission beam 2, one ends are connected with described endoscope probe 1, are used for transmitting described white light signal and/or described Cherenkov's fluorescence signal;
Calculate and imaging device 4, be connected with described sniffer 3, be used for the signal of telecommunication after the described conversion is carried out subsequent treatment, obtain the white light structural images on detected object surface and/or the inner targeting target of detected object and be combined the Cherenkov's fluoroscopic image that sends with probe.
Need to prove, described endoscope probe 1 comprises speck mirror 11, GRIN Lens 12, and transparent sheath 13, wherein, described speck mirror 11 is collected detected object surface white light signal and/or Cherenkov's fluorescence signal, and forms the photon light beam of multi-beam collimation, and described photon light beam focuses in the described imaging fiber bundle 2 through described GRIN Lens 12; Described speck mirror 11 is arranged in the described transparent sheath 13 with GRIN Lens 12.
What need to further specify is, described sniffer 3 comprises the coupled lens 31 that sets gradually, imaging len 32, and planar array detector 33, wherein, described coupled lens 31 is converted into multi-path parallel light with detected object surface white light signal and/or Cherenkov's fluorescence signal, focuses to the sensitive area of described planar array detector 33 through described imaging len 32, by described planar array detector 33 optical signal is converted into electric signal transmission to described calculating and imaging device 4 again.
What need to further specify is, described calculating and imaging device 4 comprise image pick-up card 41, and connected computer 42, and wherein, described planar array detector 33 is connected with image pick-up card 41.
As a kind of preferred scheme, described planar array detector 33 is CCD camera or CMOS camera.
Figure 3 shows that the present invention cooperates medical alimentary tract endoscope to use schematic diagram, this alimentary tract endoscope 6 is provided with four through holes, be respectively illumination channel 8, photographic head 9 and biopsy channel 7, wherein, describedly medically be arranged at described activity through Cherenkov's fluorescence imaging system of endoscope endoscope probe 1 and detect mouthfuls 7.Need to prove, during detection, described endoscope probe 1 detects mouth 7 from described activity and stretches out, and arrives near the detected object.
As shown in Figure 4, a kind of medical method through the Cherenkov of endoscope fluorescence imaging system imaging said method comprising the steps of:
(1a) gather White-light image, the illumination channel by the setting of medical alimentary tract endoscope front end provides background illumination, then utilizes the white light signal on endoscope probe acquisition target surface;
(1b) endoscope probe receives white light signal, forms the photon light beam of multi-beam collimation by the speck mirror, and it is intrafascicular that described photon light beam focuses on described imaging fiber through described GRIN Lens;
(1c) described photon light beam transfers to described sniffer by described imaging fiber bundle;
(1d) coupled lens in the described sniffer is converted into multi-path parallel light with described photon light beam, focus to the sensitive area of described planar array detector through described imaging len, by described planar array detector optical signal is converted into electric signal transmission to described calculating and imaging device again, obtains the White-light image on acquisition target surface;
(2a) gather Cherenkov's fluoroscopic image, close the illumination channel of medical alimentary tract endoscope front end, then utilize the endoscope probe collection because Cherenkov's fluorescence signal that the decay of targeting probe nuclei element emits in the object;
(2b) endoscope probe receives Cherenkov's fluorescence signal, forms the photon light beam of multi-beam collimation by the speck mirror, and it is intrafascicular that described photon light beam focuses on described imaging fiber through described GRIN Lens;
(2c) described photon light beam transfers to described sniffer by described imaging fiber bundle;
(2d) coupled lens in the described sniffer is converted into multi-path parallel light with described photon light beam, focus to the sensitive area of described planar array detector through described imaging len, by described planar array detector optical signal is converted into electric signal transmission to described calculating and imaging device again, obtains Cherenkov's fluoroscopic image on acquisition target surface.
(3) image denoising and fusion, wherein, White-light image and Cherenkov's fluoroscopic image of the object surface that step (1a) and step (2a) are collected carry out image denoising and fusion treatment to its image on computers, obtain fusion image;
(4) obtain position and the distributed intelligence of pathological changes, wherein, based on the fusion image that step (3) obtains, can obtain in the acquisition target targeting probe corresponding to its surperficial two-dimensional position information and distributed intelligence.
As a kind of preferred scheme, the time of exposure of the planar array detector in the described step (1d) is set to 0.01 second.
As a kind of preferred scheme, the time of exposure of the planar array detector in the described step (2d) is set to 5 minutes.
Need to prove, the targeted probes in the acquisition target is Na
131I nucleic probe, Cherenkov's fluorescence are to be produced by the radionuclide decay in the probe, it will be understood by those skilled in the art that targeted probes also can be
18F-FDG nucleic probe etc.
For a person skilled in the art, can make other various corresponding changes and distortion according to technical scheme described above and design, and these all changes and distortion should belong within the protection domain of claim of the present invention all.
Claims (6)
1. one kind medically is characterized in that through Cherenkov's fluorescence imaging system of endoscope, and described system comprises:
Endoscope probe be used for to gather the inner targeting target of detected object surface white light signal and/or detected object and is combined the Cherenkov's fluorescence signal that sends with probe;
Optical fiber image transmission beam, an end is connected with described endoscope probe, is used for transmitting described white light signal and/or described Cherenkov's fluorescence signal;
Sniffer is connected with the described optical fiber image transmission beam other end, is used for described white light signal and/or the Cherenkov's fluorescence signal that transmits through optical fiber image transmission beam is converted into the signal of telecommunication;
Calculate and imaging device, be connected with described sniffer, be used for the signal of telecommunication after the described conversion is carried out subsequent treatment, obtain the white light structural images on detected object surface and/or the inner targeting target of detected object and be combined the Cherenkov's fluoroscopic image that sends with probe.
2. according to claim 1 medical through Cherenkov's fluorescence imaging system of endoscope, it is characterized in that, described endoscope probe comprises the speck mirror, GRIN Lens, and transparent sheath, wherein, described speck mirror is collected detected object surface white light signal and/or Cherenkov's fluorescence signal, and the photon light beam of formation multi-beam collimation, it is intrafascicular that described photon light beam focuses on described imaging fiber through described GRIN Lens; Described speck mirror and GRIN Lens are arranged in the described transparent sheath.
3. according to claim 1 medical through Cherenkov's fluorescence imaging system of endoscope, it is characterized in that, described sniffer comprises the coupled lens that sets gradually, imaging len, and planar array detector, wherein, described coupled lens is converted into multi-path parallel light with detected object surface white light signal and/or Cherenkov's fluorescence signal, focus to the sensitive area of described planar array detector through described imaging len, by described planar array detector optical signal is converted into electric signal transmission to described calculating and imaging device again.
4. according to claim 1 or 3 described medical through Cherenkov's fluorescence imaging system of endoscope, it is characterized in that, described calculating and imaging device comprise image pick-up card, and connected computer, wherein, described planar array detector is connected with image pick-up card.
5. according to claim 4 medically it is characterized in that through Cherenkov's fluorescence imaging system of endoscope, described planar array detector is CCD camera or CMOS camera.
6. a method of utilizing claim 1 imaging is characterized in that, said method comprising the steps of:
(1a) gather White-light image, the illumination channel by the setting of medical alimentary tract endoscope front end provides background illumination, then utilizes the white light signal on endoscope probe acquisition target surface;
(1b) endoscope probe receives white light signal, forms the photon light beam of multi-beam collimation by the speck mirror, and it is intrafascicular that described photon light beam focuses on described imaging fiber through described GRIN Lens;
(1c) described photon light beam transfers to described sniffer by described imaging fiber bundle;
(1d) coupled lens in the described sniffer is converted into multi-path parallel light with described photon light beam, focus to the sensitive area of described planar array detector through described imaging len, by described planar array detector optical signal is converted into electric signal transmission to described calculating and imaging device again, obtains the White-light image on acquisition target surface;
(2a) gather Cherenkov's fluoroscopic image, close the illumination channel of medical alimentary tract endoscope front end, then utilize the endoscope probe collection because Cherenkov's fluorescence signal that the decay of targeting probe nuclei element emits in the object;
(2b) endoscope probe receives Cherenkov's fluorescence signal, forms the photon light beam of multi-beam collimation by the speck mirror, and it is intrafascicular that described photon light beam focuses on described imaging fiber through described GRIN Lens;
(2c) described photon light beam transfers to described sniffer by described imaging fiber bundle;
(2d) coupled lens in the described sniffer is converted into multi-path parallel light with described photon light beam, focus to the sensitive area of described planar array detector through described imaging len, by described planar array detector optical signal is converted into electric signal transmission to described calculating and imaging device again, obtains Cherenkov's fluoroscopic image on acquisition target surface.
(3) image denoising and fusion, wherein, White-light image and Cherenkov's fluoroscopic image of the object surface that step (1a) and step (2a) are collected carry out image denoising and fusion treatment to its image on computers, obtain fusion image;
(4) obtain position and the distributed intelligence of pathological changes, wherein, based on the fusion image that step (3) obtains, can obtain in the acquisition target targeting probe corresponding to its surperficial two-dimensional position information and distributed intelligence.
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| CN105105697A (en) * | 2015-07-03 | 2015-12-02 | 西安电子科技大学 | Medical endoscopic radiation luminescence imaging system and imaging method thereof |
| CN105167736A (en) * | 2015-08-13 | 2015-12-23 | 中国人民解放军第四军医大学 | Novel multi-modal gastroendoscope system |
| CN106388910A (en) * | 2016-08-31 | 2017-02-15 | 北京数字精准医疗科技有限公司 | Endoscopic fluorescent imaging auxiliary puncture system |
| CN106725257A (en) * | 2016-12-12 | 2017-05-31 | 中国人民解放军第四军医大学 | A kind of gasbag-type white light-multi-modal endoscopic imaging system of spoke light |
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Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070270652A1 (en) * | 2006-05-22 | 2007-11-22 | Olympus Corporation | Endoscope system |
| WO2010017218A2 (en) * | 2008-08-06 | 2010-02-11 | Mirion Technologies (Gds), Inc. (Formerly Known As Global Dosimetry Solutions, Inc.) | Method and apparatus to discriminate out interference in radiation dosage measurements |
| JP2010511463A (en) * | 2006-12-06 | 2010-04-15 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | Method for obtaining optical properties of tissue |
| CN102335005A (en) * | 2011-07-26 | 2012-02-01 | 中国科学院自动化研究所 | Cerenkov luminescence tomography (CLT) system and method adopting low-dimensional array detection |
| CN102429668A (en) * | 2011-07-28 | 2012-05-02 | 中国科学院自动化研究所 | Functional-molecular-structural imaging system and method |
| CN102469920A (en) * | 2010-06-25 | 2012-05-23 | 柯尼卡美能达精密光学株式会社 | Probe, diagnosis device, and method for using the diagnosis device |
| WO2012083503A1 (en) * | 2010-12-23 | 2012-06-28 | 中国科学院自动化研究所 | Tomography method and system based on cerenkov effect |
| US20120220870A1 (en) * | 2011-02-28 | 2012-08-30 | The Board Of Trustees Of The Leland Stanford Junior University | Optical imaging probes, optical imaging systems, methods of optical imaging, and methods of using optical imaging probes |
-
2013
- 2013-06-26 CN CN201310261548.7A patent/CN103315711B/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070270652A1 (en) * | 2006-05-22 | 2007-11-22 | Olympus Corporation | Endoscope system |
| JP2010511463A (en) * | 2006-12-06 | 2010-04-15 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | Method for obtaining optical properties of tissue |
| WO2010017218A2 (en) * | 2008-08-06 | 2010-02-11 | Mirion Technologies (Gds), Inc. (Formerly Known As Global Dosimetry Solutions, Inc.) | Method and apparatus to discriminate out interference in radiation dosage measurements |
| CN102469920A (en) * | 2010-06-25 | 2012-05-23 | 柯尼卡美能达精密光学株式会社 | Probe, diagnosis device, and method for using the diagnosis device |
| WO2012083503A1 (en) * | 2010-12-23 | 2012-06-28 | 中国科学院自动化研究所 | Tomography method and system based on cerenkov effect |
| US20120220870A1 (en) * | 2011-02-28 | 2012-08-30 | The Board Of Trustees Of The Leland Stanford Junior University | Optical imaging probes, optical imaging systems, methods of optical imaging, and methods of using optical imaging probes |
| CN102335005A (en) * | 2011-07-26 | 2012-02-01 | 中国科学院自动化研究所 | Cerenkov luminescence tomography (CLT) system and method adopting low-dimensional array detection |
| CN102429668A (en) * | 2011-07-28 | 2012-05-02 | 中国科学院自动化研究所 | Functional-molecular-structural imaging system and method |
Non-Patent Citations (3)
| Title |
|---|
| CHANGQING LI ET AL.: "Cerenkov Luminescence tomography for small-animal imaging", 《OPTICS LETTERS》 * |
| SRI-RAJASEKHAR KOTHAPALLI ET AL.: "Endoscopic imaging of Cerenkov lumiescence", 《BIOMEDICAL OPTICS EXPRESS》 * |
| 任努努等: "光学分子影像仿真平台MOSE的设计与实现", 《计算机科学》 * |
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| CN105105697A (en) * | 2015-07-03 | 2015-12-02 | 西安电子科技大学 | Medical endoscopic radiation luminescence imaging system and imaging method thereof |
| CN105167736A (en) * | 2015-08-13 | 2015-12-23 | 中国人民解放军第四军医大学 | Novel multi-modal gastroendoscope system |
| CN106388910A (en) * | 2016-08-31 | 2017-02-15 | 北京数字精准医疗科技有限公司 | Endoscopic fluorescent imaging auxiliary puncture system |
| CN106725257A (en) * | 2016-12-12 | 2017-05-31 | 中国人民解放军第四军医大学 | A kind of gasbag-type white light-multi-modal endoscopic imaging system of spoke light |
| CN107569210A (en) * | 2017-07-25 | 2018-01-12 | 西北大学 | A kind of spy Cherenkov's fluoroscopic imaging systems based on radiofluorescence guiding |
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| CN108888230A (en) * | 2018-05-21 | 2018-11-27 | 西安电子科技大学 | Cerenkov endoscopic system, medical image system based on conical fiber connection |
| CN109549612A (en) * | 2018-10-27 | 2019-04-02 | 西安电子科技大学 | The Cerenkov endoscopic system being coupled based on spatial light encoder |
| CN111759282A (en) * | 2020-07-09 | 2020-10-13 | 苏州锐一仪器科技有限公司 | Cherenkov fluorescence imaging device and medical imaging system |
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