CN108888230A - Cerenkov endoscopic system, medical image system based on conical fiber connection - Google Patents
Cerenkov endoscopic system, medical image system based on conical fiber connection Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00002—Operational features of endoscopes
- A61B1/00011—Operational features of endoscopes characterised by signal transmission
- A61B1/00013—Operational features of endoscopes characterised by signal transmission using optical means
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00163—Optical arrangements
- A61B1/00165—Optical arrangements with light-conductive means, e.g. fibre optics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
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Abstract
The invention belongs to medical imaging technology fields, disclose it is a kind of based on conical fiber connection Cerenkov endoscopic system, medical image system, including endoscopic probe, optical fiber image transmission beam, attachment device, detection device and calculating and imaging device, wherein, attachment device is conical fiber, and endoscope is connected with image camera.By the present invention in that using conical fiber as the attachment device of endoscope and image camera, the loss of optical signal of Cerenkov endoscopic system, and the configuration of the present invention is simple, fitting clinical application requirement are effectively reduced.Cerenkov light signal collection rate of the invention is high; medical endoscope adapter is replaced to carry out the connection between optical fiber image transmission beam and image camera by using conical fiber; and conical fiber is completely wrapped up using metal protection protector; loss of optical signal caused by adapter itself and coupling unit is greatly reduced; the signal acquisition time that Cerenkov endoscope is effectively imaged is reduced, the clinical conversion of Cerenkov endoscope is promoted.
Description
Technical field
The invention belongs to peep in medical imaging technology field more particularly to a kind of Cerenkov based on conical fiber connection
Mirror system, medical image system.
Background technique
Currently, the prior art commonly used in the trade is such：Endoscope has just been invented and has been applied before 100 years
In clinic, the diagnosis accuracy of disease of digestive tract is substantially increased.As science and technology continues to develop, endoscope has rapid progress,
But only morphology is imaged, lower for the identification of anatomically similar disease.Therefore, conventional white light endoscope is in disease
It is not very big for especially acting in the early detections such as tumour.With the proposition of molecular image and the maturation of Medical Imaging Technology,
Morphology imaging and molecular image, which are integrated into endoscopic apparatus, becomes a kind of new endoscope designs thinking.In recent years, contract
Lun Kefu imaging technique is continued to develop as a kind of novel optical molecular imaging technology, and imaging process can directly utilize clinic
Available nucleic probe carries out optical imagery, so that the clinic of optical molecular imaging transforms into possibility, and its imaging knot
Fruit has good consistency compared with PET result.But Cerenkov light energy is small, tissue penetration is poor, this is also very big
Limit the application of Cerenkov imaging technique.For this problem, Kothapalli etc. propose by Cerenkov imaging with it is interior
The theory combined is imaged in sight glass, by traditional optical optical fiber in conjunction with endoscope, directly using the mesh of CCD camera shooting endoscope
Mirror port, imaging results show that tumor region has higher signal strength than neighboring area；Thereafter, Cao etc. uses transfer lens
By electron multiplication CCD camera and flexible-pipe endoscope Seamless integration-, the assembling of Cerenkov endoscope is completed, makes it more suitable for facing
Bed application；Song etc. is completed in Cerenkov using transfer lens connection electron multiplication CCD camera and hard tube medicine laparoscope
The assembling of sight glass.However, contrast and experiment shows to will cause Cerenkov using transfer lens assembling Cerenkov endoscope
More losses of light reduce the collecting efficiency of Cerenkov endoscope.Currently, common medical endoscope passes through with EMCCD camera
The Cerenkov endoscopic system that transfer lens are formed by connecting for the Cerenkov light signal collection time generally need five minutes it
Long, the clinical application of Cerenkov endoscope is strongly limited.Cause the important of Cerenkov endoscope signal acquisition low efficiency
Reason is that loss of the optical signal in endoscopic system is excessive, Cerenkov optical signal decay in the entire system up to 93% with
On, and the loss of signal caused by transfer lens is wherein major part.
In conclusion problem of the existing technology is：Common medical endoscope and EMCCD camera pass through switching mirror at present
The Cerenkov endoscopic system signal acquisition low efficiency that head is formed by connecting, loss of the optical signal in endoscopic system is excessive,
Its imaging needs the time longer, greatly limits the clinical application of Cerenkov endoscope.
Solve the difficulty and meaning of above-mentioned technical problem：
Difficulty：How Cerenkov endoscopic system itself caused by loss of signal rate is reduced；
Meaning：Cerenkov endoscope signal acquisition efficiency is improved, imaging time is reduced, makes Cerenkov endoscope faster
Speed is converted to clinical application.
Summary of the invention
In view of the problems of the existing technology, the present invention provides peep in a kind of Cerenkov based on conical fiber connection
Mirror system, medical image system.
The invention is realized in this way a kind of Cerenkov endoscopic system based on conical fiber connection, described to be based on
Conical fiber connection Cerenkov endoscopic system include：
Endoscopic probe, for acquiring organism targeting target white light signal and Cerenkov fluorescence signal；
Optical fiber image transmission beam is used for transmission the white light signal and the Cerenkov fluorescence signal；
Attachment device is made of conical fiber and its protection sleeve pipe, is connected with the optical fiber image transmission beam other end, is used for
Optical fiber image transmission beam and detection device are connected, the white light signal and Cerenkov fluorescence letter of the optical fiber image transmission beam transmission are transmitted
Number；
Detection device is made of small-signal highly-sensitive detector, is connected with the attachment device other end, is used for
The white light signal and Cerenkov fluorescence signal through attachment device transmitting is collected, White-light image is obtained and Cerenkov is glimmering
Light image；
Control and computing device, are made of microcomputer, connect with the detection device, for controlling the detection dress
The signal collection set, and the White-light image and Cerenkov fluorescent image of the detected object of acquisition are pre-processed, including
The median filtering of Cerenkov fluorescent image denoises and the additive fusion of two kinds of images.
Further, the endoscopic probe includes neglecting rink corner wide-aperture lens.
Further, the objective angular field angle is no more than 45 °.
Further, the optical fiber image transmission beam by 350nm-550nm there is the glass of high transmittance to be made.
Further, the optical fiber image transmission beam making material is quartz glass.Filament diameter is not less than 25 μm.
Further, the attachment device includes conical fiber and metal protection protector；The conical fiber taper end and the light
Fine coherent fiber bundle is connected, and butt end is connected with small-signal highly-sensitive detector sensitive area in the detection device；The gold
Belong to the fully wrapped around conical fiber of protective case, one end is coupled with the optical fiber image transmission beam, faint letter in one end and the detection device
The coupling of number highly-sensitive detector.
Further, the metal protection protector butt end is standard C mouthfuls of screw thread, and the conical fiber butt end carries out trimming, in just
Rectangular port.
Another object of the present invention is to provide the Cerenkov endoscopes based on conical fiber connection described in a kind of application
The medical image system of system.
Cerenkov endoscopic system nucleic based on conical fiber connection of the invention can issue Cerenkov fluorescence, so
Light can be collected by endoscope probe afterwards, transmitted through fiber optic bundle and reached conical fiber interface, and the spy of small-signal high sensitivity is then arrived
Survey device；Small-signal highly-sensitive detector directly exports optical imagery to computer；Computer is using median filtering algorithm to adopting
The image collected carries out denoising.
In conclusion advantages of the present invention and good effect are：Including endoscopic probe, optical fiber image transmission beam, attachment device, spy
Survey device and control and computing device, wherein attachment device is conical fiber, and endoscope is connected with image camera.This hair
The bright attachment device by using conical fiber as endoscope and image camera, effectively reduces Cerenkov endoscopic system
Loss of optical signal, and the configuration of the present invention is simple, fitting clinical application requirement.
Cerenkov light signal collection rate of the invention is high, by using conical fiber replace medical endoscope adapter into
Connection between row optical fiber image transmission beam and image camera, and conical fiber is completely wrapped up using metal protection protector, it is greatly reduced
Loss of optical signal caused by adapter itself and coupling unit, when reducing the signal acquisition that Cerenkov endoscope is effectively imaged
Between, promote the clinical conversion of Cerenkov endoscope.
The present invention is versatile, easy to operate, since Cerenkov endoscopic system of the invention need to only be peeped with commonly interior
Mirror is used in combination, and does not need special endoscope support, and Cerenkov light letter can be completed by replacing medical adapter position
Number high efficiency acquisition.Connecting system according to adapter stated in the background will cause the damage of the signal more than 90% or more
It loses, and according to the characteristic of light cone, the loss of signal caused by adapter can be effectively reduced, signal acquisition rate is promoted to adapter system
8~10 times of signal acquisition rate of uniting.
Detailed description of the invention
Fig. 1 is the Cerenkov endoscopic system structural representation provided in an embodiment of the present invention based on conical fiber connection
Figure；
Fig. 2 is the Cerenkov endoscopic system principle signal provided in an embodiment of the present invention based on conical fiber connection
Figure；
Fig. 3 is conical fiber schematic diagram provided in an embodiment of the present invention.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, with reference to embodiments, to the present invention
It is further elaborated.It should be appreciated that described herein, specific examples are only used to explain the present invention, is not used to limit
The fixed present invention.
The present invention provides the Cerenkov endoscopic systems that transfer lens are replaced using conical fiber, pass through conical fiber
Endoscope and small-signal highly-sensitive detector are connected, Cerenkov optical signal caused by transfer lens position is greatly reduced and damages
It loses, improves Cerenkov endoscope light signal collection efficiency.
As shown in Figure 1, the Cerenkov endoscopic system provided in an embodiment of the present invention based on conical fiber connection includes：
Endoscopic probe 1 using optical wavelength 350nm-550nm there is the lens group of high transmittance to form, be suitable for Qi Lunke
Husband's fluorescence penetrates, for acquiring the white light signal and Cerenkov fluorescence signal of detected object；
Optical fiber image transmission beam 2, one end are connected with the endoscope probe 1, have height using optical wavelength 350nm-550nm
The optical fiber of transmitance forms, and one end is connected with endoscopic probe, is used for transmission the white light signal and the Cerenkov is glimmering
Optical signal；
Attachment device 3 is connected, for connecting optical fiber image transmission beam 2 and detection device with 2 other end of optical fiber image transmission beam
4, transmit the white light signal and Cerenkov fluorescence signal of the optical fiber image transmission beam transmission；
Detection device 4 is connected with 3 other end of attachment device, described through the white of attachment device transmitting for collecting
Optical signal and Cerenkov fluorescence signal obtain White-light image and Cerenkov fluorescent image；
Control and computing device 5, connect with the detection device 4, for controlling the signal collection of the detection device, with
And the White-light image and Cerenkov fluorescent image of the detected object of acquisition are pre-processed, including Cerenkov fluorescent image
Median filtering denoising and two kinds of images additive fusion.
Endoscope probe 1 includes neglecting rink corner wide-aperture lens 11, has higher transmission to Cerenkov fluorescence signal
Rate can more effectively collect Cerenkov fluorescence signal；
The field angle of object lens 11 is no more than 45 °；2 making material of optical fiber image transmission beam is quartz glass；2 monofilament of optical fiber image transmission beam
Diameter is not less than 25 μm；
It includes metal protection protector 31 and conical fiber 32 that connection, which carries down and sets 3, wherein the conical fiber taper end and the light
Fine coherent fiber bundle 2 is connected, and butt end is connected with 41 sensitive area of small-signal highly-sensitive detector in the detection device；Institute
The fully wrapped around conical fiber 32 of metal protection protector 31 is stated, one end is coupled with the optical fiber image transmission beam 2, one end and the detection device
Middle small-signal highly-sensitive detector sensitive area 41 couples.
Detection device 4 includes small-signal highly-sensitive detector sensitive area 41, the small-signal high sensitivity detection
Device 41 is by white light signal and Cerenkov fluorescence signal collection and is transmitted to the control and computing device 5；
Small-signal highly-sensitive detector 4 can be highly sensitive Scientific Grade charge-coupled device；Metal protection protector 31 is thick
End is standard C mouthfuls of screw thread；Trimming, square port, as shown in 33, so as to better are carried out to 32 butt end of conical fiber
It is bonded highly sensitive Scientific Grade charged coupled device chip；
Control is computer 51 with computing device 5, wherein small-signal highly-sensitive detector 4 is connected with computer 51
It connects.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Made any modifications, equivalent replacements, and improvements etc., should all be included in the protection scope of the present invention within mind and principle.
Claims (10)
1. a kind of Cerenkov endoscopic system based on conical fiber connection, which is characterized in that described to be connected based on conical fiber
The Cerenkov endoscopic system connect includes：
Endoscopic probe, for acquiring organism targeting target white light signal and Cerenkov fluorescence signal；
Optical fiber image transmission beam is used for transmission the white light signal and the Cerenkov fluorescence signal；
Attachment device is made of conical fiber and its protection sleeve pipe, is connected with the optical fiber image transmission beam other end, for connecting
Optical fiber image transmission beam and detection device transmit the white light signal and Cerenkov fluorescence signal of the optical fiber image transmission beam transmission；
Detection device is made of small-signal highly-sensitive detector, is connected with the attachment device other end, for collecting
The white light signal and Cerenkov fluorescence signal through attachment device transmitting, obtains White-light image and Cerenkov fluorogram
Picture；
Calculating and imaging device, are made of microcomputer, connect with the detection device, for controlling the detection device
Signal collection, and the White-light image and Cerenkov fluorescent image of the detected object of acquisition are pre-processed, including contract human relations
The median filtering of section's husband's fluorescent image denoises and the additive fusion of two kinds of images.
2. the Cerenkov endoscopic system as described in claim 1 based on conical fiber connection, which is characterized in that in described
Mirror probe includes neglecting rink corner wide-aperture lens.
3. the Cerenkov endoscopic system as claimed in claim 2 based on conical fiber connection, which is characterized in that the object
Mirror field angle is no more than 45 °.
4. the Cerenkov endoscopic system as described in claim 1 based on conical fiber connection, which is characterized in that the light
Fine coherent fiber bundle by 350nm-550nm there is the glass of high transmittance to be made.
5. the Cerenkov endoscopic system as claimed in claim 4 based on conical fiber connection, which is characterized in that the light
Fine coherent fiber bundle making material is quartz glass；Filament diameter is not less than 25 μm.
6. the Cerenkov endoscopic system as described in claim 1 based on conical fiber connection, which is characterized in that the company
Connection device includes conical fiber and metal protection protector；The conical fiber taper end is connected with the optical fiber image transmission beam, butt end with
Small-signal highly-sensitive detector sensitive area is connected in the detection device；The fully wrapped around cone of light of metal protection protector
Fibre, one end are coupled with the optical fiber image transmission beam, and one end is coupled with small-signal highly-sensitive detector in the detection device.
7. the Cerenkov endoscopic system as described in claim 1 based on conical fiber connection, which is characterized in that the spy
Surveying device includes small-signal highly-sensitive detector sensitive area, and the small-signal highly-sensitive detector is described for collecting
White light signal and Cerenkov fluorescence signal through attachment device transmitting, obtain White-light image and Cerenkov fluorescent image.
8. the Cerenkov endoscopic system as claimed in claim 6 based on conical fiber connection, which is characterized in that the gold
Category protective case butt end is standard C mouthfuls of screw thread, and the conical fiber butt end carries out trimming, square port.
9. the Cerenkov endoscopic system as described in claim 1 based on conical fiber connection, which is characterized in that the meter
Calculating with imaging device includes computer, and the signal detection device is connected to a computer.
10. a kind of Cerenkov endoscopic system using based on conical fiber connection described in claim 1~9 any one
Medical image system.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110515114A (en) * | 2019-08-26 | 2019-11-29 | 西安交通大学医学院第一附属医院 | Cherenkov's optical acquisition device and acquisition method in a kind of high-performance Patients During Radiotherapy |
| CN111759282A (en) * | 2020-07-09 | 2020-10-13 | 苏州锐一仪器科技有限公司 | Cherenkov fluorescence imaging device and medical imaging system |
| CN111759281A (en) * | 2020-07-09 | 2020-10-13 | 苏州锐一仪器科技有限公司 | Signal detection device and system |
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