CN107532119A - 用于微流体装置的培养站 - Google Patents

用于微流体装置的培养站 Download PDF

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Publication number
CN107532119A
CN107532119A CN201680023432.1A CN201680023432A CN107532119A CN 107532119 A CN107532119 A CN 107532119A CN 201680023432 A CN201680023432 A CN 201680023432A CN 107532119 A CN107532119 A CN 107532119A
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China
Prior art keywords
microfluidic device
microfluidic
station
flow
culture
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CN201680023432.1A
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English (en)
Chinese (zh)
Inventor
凯斯·J·布林格
罗素·A·纽斯壮
J·坦纳·内维尔
J·M·麦克尤恩
大卫·A·威斯贝克
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Bruker Cellular Analysis Inc
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Berkeley Lights Inc
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Publication of CN107532119A publication Critical patent/CN107532119A/zh
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    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/58—Reaction vessels connected in series or in parallel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/08—Flask, bottle or test tube
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    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
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    • C12M23/20—Material Coatings
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    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/22—Transparent or translucent parts
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    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/24—Gas permeable parts
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    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/26—Constructional details, e.g. recesses, hinges flexible
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    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/34—Internal compartments or partitions
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    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/38—Caps; Covers; Plugs; Pouring means
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    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/44—Multiple separable units; Modules
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    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/50—Means for positioning or orientating the apparatus
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    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/06—Means for regulation, monitoring, measurement or control, e.g. flow regulation of illumination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
    • C12M41/18—Heat exchange systems, e.g. heat jackets or outer envelopes
    • C12M41/22—Heat exchange systems, e.g. heat jackets or outer envelopes in contact with the bioreactor walls
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/44—Means for regulation, monitoring, measurement or control, e.g. flow regulation of volume or liquid level
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
    • C—CHEMISTRY; METALLURGY
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    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples

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  • Molecular Biology (AREA)
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  • Computer Hardware Design (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201680023432.1A 2015-04-22 2016-04-21 用于微流体装置的培养站 Pending CN107532119A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562178960P 2015-04-22 2015-04-22
US62/178,960 2015-04-22
PCT/US2016/028661 WO2016172350A1 (en) 2015-04-22 2016-04-21 Culturing station for microfluidic device

Publications (1)

Publication Number Publication Date
CN107532119A true CN107532119A (zh) 2018-01-02

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US (1) US20160340632A1 (enExample)
EP (1) EP3286298A1 (enExample)
JP (3) JP6805166B2 (enExample)
KR (2) KR102415433B1 (enExample)
CN (1) CN107532119A (enExample)
AU (2) AU2016250580B2 (enExample)
CA (1) CA2982412C (enExample)
HK (1) HK1248750A1 (enExample)
IL (2) IL290119B2 (enExample)
SG (2) SG11201708482SA (enExample)
TW (1) TWI712686B (enExample)
WO (1) WO2016172350A1 (enExample)

Cited By (4)

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CN109465040A (zh) * 2018-10-16 2019-03-15 佛山翼卿科技有限公司 一种微流控芯片的密封装置
CN110064445A (zh) * 2018-01-24 2019-07-30 伊鲁米那股份有限公司 流体缓冲
CN112041071A (zh) * 2018-05-15 2020-12-04 宝洁公司 微流体料盒和包括该微流体料盒的微流体递送装置
CN114630890A (zh) * 2019-08-13 2022-06-14 弗拉斯沃克斯有限责任公司 用于细胞培养系统的工作周期

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JP7356351B2 (ja) 2016-12-12 2023-10-04 エクセラ・バイオサイエンシーズ・インコーポレイテッド マイクロキャピラリーアレイを使用したスクリーニングのための方法およびシステム
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JP7227162B2 (ja) 2017-06-06 2023-02-21 ザイマージェン インコーポレイテッド 真菌株を改良するためのｈｔｐゲノム操作プラットフォーム
US11926814B2 (en) * 2017-08-23 2024-03-12 Northwestern University Multi-chamber fluidic platform
KR20240149973A (ko) * 2017-10-16 2024-10-15 리제너론 파마슈티칼스 인코포레이티드 세포 배양에서 공정 변수를 제어하기 위한 원위치 라만 분광법 시스템 및 방법
JP2021526799A (ja) 2018-06-06 2021-10-11 ザイマージェン インコーポレイテッド 発酵および産生中の真菌の形態を制御するためのシグナル伝達に関与する遺伝子の操作
EP3820613A4 (en) * 2018-07-12 2022-04-20 Berkeley Lights, Inc. Screening plant protoplasts for disease resistant traits
GB201812192D0 (en) 2018-07-26 2018-09-12 Ttp Plc Variable temperature reactor, heater and control circuit for the same
IL280880B2 (en) 2018-08-27 2025-04-01 Regeneron Pharma Using Raman Spectroscopy in Downstream Purification
AR116719A1 (es) * 2018-10-10 2021-06-09 Stamm Vegh Corp Microbiorreactor de flujo continuo
ES3039910T3 (en) 2018-12-06 2025-10-27 Xcella Biosciences Inc Lateral loading of microcapillary arrays
WO2020168258A1 (en) 2019-02-15 2020-08-20 Berkeley Lights, Inc. Laser-assisted repositioning of a micro-object and culturing of an attachment-dependent cell in a microfluidic environment
JP7314253B2 (ja) 2019-03-19 2023-07-25 富士フイルム株式会社 情報処理装置、細胞培養システム、情報処理方法、及び情報処理プログラム
EP3943586A4 (en) * 2019-03-19 2022-05-04 FUJIFILM Corporation CELL CULTURE SYSTEM AND CELL CULTURE METHODS
CN114126762B (zh) 2019-04-30 2023-01-03 伯克利之光生命科技公司 用于包封和测定细胞的方法
ES2930540T3 (es) * 2019-12-20 2022-12-16 Astraveus Dispositivo de bioprocesamiento
EP4450281A3 (en) 2020-02-03 2025-01-22 Stamm Vegh Corporation Platform, systems, and devices for 3d printing
DE102020107599B3 (de) * 2020-03-19 2021-07-22 Ibidi Gmbh Verfahren zur Kultivierung von Zellen
US20230220323A1 (en) * 2020-07-07 2023-07-13 Shimadzu Corporation Cell culture system
US11479779B2 (en) 2020-07-31 2022-10-25 Zymergen Inc. Systems and methods for high-throughput automated strain generation for non-sporulating fungi
EP4206311A4 (en) * 2020-08-26 2025-08-20 Shimadzu Corp CELL CULTURE VESSEL AND CELL CULTURE SYSTEM
KR102605221B1 (ko) * 2021-07-02 2023-11-24 고려대학교 산학협력단 세포 광자극 장치
US12252678B2 (en) 2021-12-01 2025-03-18 Microfluidx Ltd Systems and methods for bioprocessing
TWI833614B (zh) * 2023-03-23 2024-02-21 揚朋科技股份有限公司 細胞製備系統

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