JP6805166B2 - マイクロ流体デバイス用の培養ステーション - Google Patents

マイクロ流体デバイス用の培養ステーション Download PDF

Info

Publication number
JP6805166B2
JP6805166B2 JP2017553138A JP2017553138A JP6805166B2 JP 6805166 B2 JP6805166 B2 JP 6805166B2 JP 2017553138 A JP2017553138 A JP 2017553138A JP 2017553138 A JP2017553138 A JP 2017553138A JP 6805166 B2 JP6805166 B2 JP 6805166B2
Authority
JP
Japan
Prior art keywords
microfluidic device
culture
microfluidic
mounting interface
minutes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2017553138A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018512853A (ja
JP2018512853A5 (enExample
Inventor
ブレインリンガー,キース,ジェイ.
ニューストローム,ラッセル,エー.
ネビル,ジェイ.,タナー
マッキュアン,ジェイソン,エム.
ワイスバッハ,デイビット,エー.
Original Assignee
バークレー ライツ,インコーポレイテッド
バークレー ライツ,インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by バークレー ライツ,インコーポレイテッド, バークレー ライツ,インコーポレイテッド filed Critical バークレー ライツ,インコーポレイテッド
Publication of JP2018512853A publication Critical patent/JP2018512853A/ja
Publication of JP2018512853A5 publication Critical patent/JP2018512853A5/ja
Application granted granted Critical
Publication of JP6805166B2 publication Critical patent/JP6805166B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/58Reaction vessels connected in series or in parallel
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/02Form or structure of the vessel
    • C12M23/08Flask, bottle or test tube
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/02Form or structure of the vessel
    • C12M23/16Microfluidic devices; Capillary tubes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/20Material Coatings
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/22Transparent or translucent parts
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/24Gas permeable parts
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/26Constructional details, e.g. recesses, hinges flexible
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/34Internal compartments or partitions
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/38Caps; Covers; Plugs; Pouring means
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/44Multiple separable units; Modules
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/50Means for positioning or orientating the apparatus
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10Perfusion
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M37/00Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/06Means for regulation, monitoring, measurement or control, e.g. flow regulation of illumination
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
    • C12M41/18Heat exchange systems, e.g. heat jackets or outer envelopes
    • C12M41/22Heat exchange systems, e.g. heat jackets or outer envelopes in contact with the bioreactor walls
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/44Means for regulation, monitoring, measurement or control, e.g. flow regulation of volume or liquid level
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48Automatic or computerized control
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00Heating or cooling apparatus; Heat insulating devices
    • B01L7/52Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Sustainable Development (AREA)
  • Clinical Laboratory Science (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Thermal Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Computer Hardware Design (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2017553138A 2015-04-22 2016-04-21 マイクロ流体デバイス用の培養ステーション Active JP6805166B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562178960P 2015-04-22 2015-04-22
US62/178,960 2015-04-22
PCT/US2016/028661 WO2016172350A1 (en) 2015-04-22 2016-04-21 Culturing station for microfluidic device

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020201015A Division JP7185678B2 (ja) 2015-04-22 2020-12-03 マイクロ流体デバイス用の培養ステーション

Publications (3)

Publication Number Publication Date
JP2018512853A JP2018512853A (ja) 2018-05-24
JP2018512853A5 JP2018512853A5 (enExample) 2019-05-30
JP6805166B2 true JP6805166B2 (ja) 2020-12-23

Family

ID=55911084

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2017553138A Active JP6805166B2 (ja) 2015-04-22 2016-04-21 マイクロ流体デバイス用の培養ステーション
JP2020201015A Active JP7185678B2 (ja) 2015-04-22 2020-12-03 マイクロ流体デバイス用の培養ステーション
JP2022188128A Pending JP2023014165A (ja) 2015-04-22 2022-11-25 マイクロ流体デバイス用の培養ステーション

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2020201015A Active JP7185678B2 (ja) 2015-04-22 2020-12-03 マイクロ流体デバイス用の培養ステーション
JP2022188128A Pending JP2023014165A (ja) 2015-04-22 2022-11-25 マイクロ流体デバイス用の培養ステーション

Country Status (12)

Country Link
US (1) US20160340632A1 (enExample)
EP (1) EP3286298A1 (enExample)
JP (3) JP6805166B2 (enExample)
KR (2) KR102415433B1 (enExample)
CN (1) CN107532119A (enExample)
AU (2) AU2016250580B2 (enExample)
CA (1) CA2982412C (enExample)
HK (1) HK1248750A1 (enExample)
IL (2) IL290119B2 (enExample)
SG (2) SG11201708482SA (enExample)
TW (1) TWI712686B (enExample)
WO (1) WO2016172350A1 (enExample)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018064775A1 (en) * 2016-10-07 2018-04-12 Xinyu Liu A microfluidic analytical platform for autonomous immunoassays
JP7356351B2 (ja) 2016-12-12 2023-10-04 エクセラ・バイオサイエンシーズ・インコーポレイテッド マイクロキャピラリーアレイを使用したスクリーニングのための方法およびシステム
WO2018125832A1 (en) 2016-12-30 2018-07-05 xCella Biosciences, Inc. Multi-stage sample recovery system
JP7227162B2 (ja) 2017-06-06 2023-02-21 ザイマージェン インコーポレイテッド 真菌株を改良するためのhtpゲノム操作プラットフォーム
US11926814B2 (en) * 2017-08-23 2024-03-12 Northwestern University Multi-chamber fluidic platform
KR20240149973A (ko) * 2017-10-16 2024-10-15 리제너론 파마슈티칼스 인코포레이티드 세포 배양에서 공정 변수를 제어하기 위한 원위치 라만 분광법 시스템 및 방법
TWI699494B (zh) * 2018-01-24 2020-07-21 美商伊路米納有限公司 流體緩衝
US10307783B1 (en) * 2018-05-15 2019-06-04 The Procter & Gamble Company Microfluidic cartridge and microfluidic delivery device comprising the same
JP2021526799A (ja) 2018-06-06 2021-10-11 ザイマージェン インコーポレイテッド 発酵および産生中の真菌の形態を制御するためのシグナル伝達に関与する遺伝子の操作
EP3820613A4 (en) * 2018-07-12 2022-04-20 Berkeley Lights, Inc. Screening plant protoplasts for disease resistant traits
GB201812192D0 (en) 2018-07-26 2018-09-12 Ttp Plc Variable temperature reactor, heater and control circuit for the same
IL280880B2 (en) 2018-08-27 2025-04-01 Regeneron Pharma Using Raman Spectroscopy in Downstream Purification
AR116719A1 (es) * 2018-10-10 2021-06-09 Stamm Vegh Corp Microbiorreactor de flujo continuo
CN109465040B (zh) * 2018-10-16 2021-05-04 浙江优众新材料科技有限公司 一种微流控芯片的密封装置
ES3039910T3 (en) 2018-12-06 2025-10-27 Xcella Biosciences Inc Lateral loading of microcapillary arrays
WO2020168258A1 (en) 2019-02-15 2020-08-20 Berkeley Lights, Inc. Laser-assisted repositioning of a micro-object and culturing of an attachment-dependent cell in a microfluidic environment
JP7314253B2 (ja) 2019-03-19 2023-07-25 富士フイルム株式会社 情報処理装置、細胞培養システム、情報処理方法、及び情報処理プログラム
EP3943586A4 (en) * 2019-03-19 2022-05-04 FUJIFILM Corporation CELL CULTURE SYSTEM AND CELL CULTURE METHODS
CN114126762B (zh) 2019-04-30 2023-01-03 伯克利之光生命科技公司 用于包封和测定细胞的方法
US11566217B2 (en) * 2019-08-13 2023-01-31 Flaskworks, Llc Duty cycle for cell culture systems
ES2930540T3 (es) * 2019-12-20 2022-12-16 Astraveus Dispositivo de bioprocesamiento
EP4450281A3 (en) 2020-02-03 2025-01-22 Stamm Vegh Corporation Platform, systems, and devices for 3d printing
DE102020107599B3 (de) * 2020-03-19 2021-07-22 Ibidi Gmbh Verfahren zur Kultivierung von Zellen
US20230220323A1 (en) * 2020-07-07 2023-07-13 Shimadzu Corporation Cell culture system
US11479779B2 (en) 2020-07-31 2022-10-25 Zymergen Inc. Systems and methods for high-throughput automated strain generation for non-sporulating fungi
EP4206311A4 (en) * 2020-08-26 2025-08-20 Shimadzu Corp CELL CULTURE VESSEL AND CELL CULTURE SYSTEM
KR102605221B1 (ko) * 2021-07-02 2023-11-24 고려대학교 산학협력단 세포 광자극 장치
US12252678B2 (en) 2021-12-01 2025-03-18 Microfluidx Ltd Systems and methods for bioprocessing
TWI833614B (zh) * 2023-03-23 2024-02-21 揚朋科技股份有限公司 細胞製備系統

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7914994B2 (en) * 1998-12-24 2011-03-29 Cepheid Method for separating an analyte from a sample
US6942776B2 (en) 1999-05-18 2005-09-13 Silicon Biosystems S.R.L. Method and apparatus for the manipulation of particles by means of dielectrophoresis
US7507579B2 (en) * 2002-05-01 2009-03-24 Massachusetts Institute Of Technology Apparatus and methods for simultaneous operation of miniaturized reactors
US7745203B2 (en) * 2002-07-31 2010-06-29 Kabushiki Kaisha Toshiba Base sequence detection apparatus and base sequence automatic analyzing apparatus
CN1177033C (zh) * 2002-11-05 2004-11-24 中国科学院上海技术物理研究所 动态空间细胞培养系统
WO2005100541A2 (en) 2004-04-12 2005-10-27 The Regents Of The University Of California Optoelectronic tweezers for microparticle and cell manipulation
GB0505379D0 (en) * 2005-03-16 2005-04-20 Robio Systems Ltd Cellular entity maturation and transportation systems
JP2006308332A (ja) * 2005-04-26 2006-11-09 Moritex Corp 固定反応物質と液体反応物質との反応用フローセル及び反応装置並びに反応装置の運転方法
WO2007014190A2 (en) * 2005-07-25 2007-02-01 Bioprocessors Corp. Computerized factorial experimental design and control of reaction sites and arrays thereof
US9248421B2 (en) * 2005-10-07 2016-02-02 Massachusetts Institute Of Technology Parallel integrated bioreactor device and method
US8124033B2 (en) * 2006-02-17 2012-02-28 Agency, Science, Technology and Research Apparatus for regulating the temperature of a biological and/or chemical sample and method of using the same
WO2008119066A1 (en) 2007-03-28 2008-10-02 The Regents Of The University Of California Single-sided lateral-field and phototransistor-based optoelectronic tweezers
EP2564206A4 (en) * 2010-04-29 2016-09-07 Leica Biosystems Richmond Inc ANALYSIS SYSTEM FOR CARRYING OUT LABORATORY PROTOCOLS AND RELATED METHODS
CH703278B1 (fr) * 2010-06-15 2016-11-15 Csem Centre Suisse D'electronique Et De Microtechnique Sa - Rech Et Développement Appareil et plateforme pour analyse multiplex.
TW201209406A (en) * 2010-06-17 2012-03-01 Geneasys Pty Ltd Test module with microfluidic device having LOC and dialysis device for separating pathogens from other constituents in a biological sample
WO2013086505A1 (en) * 2011-12-09 2013-06-13 Vanderbilt University Integrated organ-on-chip system and applications of the same
WO2014081840A1 (en) * 2012-11-21 2014-05-30 Vanderbilt University Organ on chip integration and applications of the same
US20140308688A1 (en) * 2011-12-08 2014-10-16 Research Triangle Institute Human emulated response with microfluidic enhanced systems
JP6318094B2 (ja) * 2012-02-27 2018-05-09 エコール ポリテクニーク フェデラーレ ドゥ ローザンヌ(エペエフエル)Ecole Polytechnique Federale de Lausanne(EPFL) スライドが着脱可能な試料処理デバイス
US9403172B2 (en) 2012-11-08 2016-08-02 Berkeley Lights, Inc. Circuit based optoelectronic tweezers
CN103667054B (zh) * 2013-09-18 2015-09-30 中国航天员科研训练中心 一种集成化微流控细胞培养芯片及其制备方法
CA2927701C (en) * 2013-10-22 2020-10-13 Berkeley Lights, Inc. Microfluidic devices having sequestration pens and methods of testing biological micro-objects with same
CN104073426B (zh) * 2014-06-27 2016-03-30 江苏卓微生物科技有限公司 细胞检测芯片适配器安装座

Also Published As

Publication number Publication date
KR20170137203A (ko) 2017-12-12
SG10202011358PA (en) 2020-12-30
IL255158A0 (en) 2017-12-31
IL290119B1 (en) 2023-11-01
KR102546378B1 (ko) 2023-06-21
WO2016172350A1 (en) 2016-10-27
AU2016250580A1 (en) 2017-11-02
IL290119A (en) 2022-03-01
AU2021203363B2 (en) 2023-02-02
CN107532119A (zh) 2018-01-02
TW201643240A (zh) 2016-12-16
IL290119B2 (en) 2024-03-01
JP2021035398A (ja) 2021-03-04
HK1248750A1 (zh) 2018-10-19
KR102415433B1 (ko) 2022-06-30
CA2982412A1 (en) 2016-10-27
JP7185678B2 (ja) 2022-12-07
SG11201708482SA (en) 2017-11-29
JP2023014165A (ja) 2023-01-26
EP3286298A1 (en) 2018-02-28
US20160340632A1 (en) 2016-11-24
TWI712686B (zh) 2020-12-11
AU2016250580B2 (en) 2021-02-25
JP2018512853A (ja) 2018-05-24
KR20220097548A (ko) 2022-07-07
AU2021203363A1 (en) 2021-06-24
CA2982412C (en) 2023-01-03
IL255158B (en) 2022-02-01

Similar Documents

Publication Publication Date Title
JP6805166B2 (ja) マイクロ流体デバイス用の培養ステーション
US10578630B2 (en) Automated identification of assay areas in a microfluidic device and detection of assay positive areas based on rate of change of image light intensity
KR102221894B1 (ko) 격리 펜을 갖는 미세유체 소자 및 이를 사용한 생물학적 미세 물체를 시험하는 방법
US20210069698A1 (en) Microfluidic reporter cell assay methods and kits thereof
TW202233824A (zh) 微流體器件及在該微流體器件中培養生物細胞之方法
CN105849561B (zh) 用于测定生物活性的微流体装置
WO2015061462A9 (en) Exporting a selected group of micro-objects from a micro-fluidic device
CN105658781B (zh) 具有隔离围栏的微流体装置及用它测试生物微目标的方法
JP2023500623A (ja) マイクロ流体デバイスを作動させるためのシステム
HK40005414A (en) Exporting a selected group of micro-objects from a micro-fluidic device
HK1244465B (zh) 微流体装置中测定阳性的区域的自动检测
HK1225407B (zh) 具有隔离围栏的微流体装置及用它测试生物微目标的方法
HK1245184B (zh) 微流体装置中定向流动的致动微流体结构及使用它的方法

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20190419

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20190419

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20200122

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20200207

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20200507

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200707

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20201006

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20201030

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20201203

R150 Certificate of patent or registration of utility model

Ref document number: 6805166

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250