CN107531746B8 - 9β,10α-孕甾-4,6-二烯-3,20-二酮的制备方法 - Google Patents

9β,10α-孕甾-4,6-二烯-3,20-二酮的制备方法 Download PDF

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Publication number
CN107531746B8
CN107531746B8 CN201580003224.0A CN201580003224A CN107531746B8 CN 107531746 B8 CN107531746 B8 CN 107531746B8 CN 201580003224 A CN201580003224 A CN 201580003224A CN 107531746 B8 CN107531746 B8 CN 107531746B8
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diene
dione
preparation
pregnan
pregna
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CN107531746B (zh
CN107531746A (zh
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董军国
吴志平
陈济谷
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Taizhou Hisound Pharmaceutical Co ltd
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Taizhou Hisound Pharmaceutical Co ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J15/00—Stereochemically pure steroids containing carbon, hydrogen, halogen or oxygen having a partially or totally inverted skeleton, e.g. retrosteroids, L-isomers
    • C07J15/005—Retrosteroids (9 beta 10 alfa)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

本发明是有关于一种9β,10α-孕甾-4,6-二烯-3,20-二酮的制备方法。该制备方法以9β,10α-孕甾-5,7-二烯-3,20-二酮二乙二缩醛(化合物A)为原料，在酸性条件下解保护得到9β,10α-孕甾-4,7-二烯-3,20-二酮(化合物B)，然后在碱性条件下重排得到9β,10α-孕甾-4,6-二烯-3,20-二酮(化合物C)。本发明的方法简单、环保且收率极高。
CN201580003224.0A 2015-04-02 2015-04-02 9β,10α-孕甾-4,6-二烯-3,20-二酮的制备方法 Active CN107531746B8 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2015/000231 WO2016154772A1 (zh) 2015-04-02 2015-04-02 9β，10α-孕甾-4，6-二烯-3，20-二酮的制备方法

Publications (3)

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CN107531746A CN107531746A (zh) 2018-01-02
CN107531746B CN107531746B (zh) 2020-03-31
CN107531746B8 true CN107531746B8 (zh) 2023-11-10

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CN (1) CN107531746B8 (zh)
WO (1) WO2016154772A1 (zh)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113880904B (zh) * 2020-07-01 2024-04-12 苏州朗科生物技术股份有限公司 合成地屈孕酮的新方法及化合物
CN112812146A (zh) * 2021-01-20 2021-05-18 江苏诺维尔医药科技有限公司 一种合成地屈孕酮的方法
CN113666981A (zh) * 2021-08-27 2021-11-19 江西百思康瑞药业有限公司 一种地屈孕酮的合成方法
CN114249790B (zh) * 2021-09-03 2022-10-18 扬州奥锐特药业有限公司 一种甾体化合物的制备方法
WO2023035906A1 (zh) * 2021-09-08 2023-03-16 湖南醇康医药科技有限公司 中间体化合物及其制备方法和应用
CN114437164B (zh) * 2022-01-26 2024-01-30 西安国康瑞金制药有限公司 一种地屈孕酮及其制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL301566A (zh) *

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL146503B (nl) * 1963-12-09 1975-07-15 Philips Nv Werkwijze voor de bereiding van een 9beta, 10alfa-pregna-4,6-dieen-3,20-dion.
CN103314004B (zh) * 2011-12-02 2015-07-08 台州市海盛制药有限公司 5,7-孕甾二烯-3,20-二酮-二乙二缩酮新的制备方法
CN104237417B (zh) * 2014-09-30 2017-06-23 华润紫竹药业有限公司 一种地屈孕酮中间体的分析方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL301566A (zh) *

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Steroids. XIII. Steroidal cyclic ketals. 2. The preparation of;Antonucci, Rose等;《Journal of Organic Chemistry》;19521231(第17期);1371-1373，III制备IV *
Sterols. XIX. 6-Dehydro-9β 10α-progesterone from pregnenolone;Rappoldt, M. P.等;《Recueil des Travaux Chimiques des Pays-Bas et de la Belgique 》;19611231(第80期);44,46 *

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WO2016154772A1 (zh) 2016-10-06
CN107531746A (zh) 2018-01-02

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GR01 Patent grant
CI03 Correction of invention patent

Correction item: Patentee

Correct: TAIZHOU HISOUND PHARMACEUTICAL Co.,Ltd.

False: TAIZHOU HISOUND PHARMACEUTICAL CO.,LTD.

Number: 14-01

Page: The title page

Volume: 36

Correction item: Patentee

Correct: TAIZHOU HISOUND PHARMACEUTICAL Co.,Ltd.

False: TAIZHOU HISOUND PHARMACEUTICAL CO.,LTD.

Number: 14-01

Volume: 36

CI03 Correction of invention patent
OR01 Other related matters
OR01 Other related matters