WO2015102022A3 - An improved process for the preparation of abiraterone acetate - Google Patents

An improved process for the preparation of abiraterone acetate Download PDF

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Publication number
WO2015102022A3
WO2015102022A3 PCT/IN2014/000808 IN2014000808W WO2015102022A3 WO 2015102022 A3 WO2015102022 A3 WO 2015102022A3 IN 2014000808 W IN2014000808 W IN 2014000808W WO 2015102022 A3 WO2015102022 A3 WO 2015102022A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
abiraterone acetate
improved process
relates
abiraterone
Prior art date
Application number
PCT/IN2014/000808
Other languages
French (fr)
Other versions
WO2015102022A2 (en
Inventor
Satyanarayana Chava
Seeta Rama Anjaneyulu GORANTLA
Venkata Sunil Kumar Indukuri
Sanjay Kumar Dehury
Sivarami Reddy BATTULA
Original Assignee
Laurus Labs Private Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laurus Labs Private Limited filed Critical Laurus Labs Private Limited
Publication of WO2015102022A2 publication Critical patent/WO2015102022A2/en
Publication of WO2015102022A3 publication Critical patent/WO2015102022A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

The present invention relates to an improved process for the preparation of abiraterone acetate. More specifically the invention relates to a process for the preparation of abiraterone acetate free from dimer and other impurities.
PCT/IN2014/000808 2013-12-31 2014-12-31 An improved process for the preparation of abiraterone acetate WO2015102022A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN6193CH2013 2013-12-31
IN6193/CHE/2013 2013-12-31

Publications (2)

Publication Number Publication Date
WO2015102022A2 WO2015102022A2 (en) 2015-07-09
WO2015102022A3 true WO2015102022A3 (en) 2015-08-27

Family

ID=53494171

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2014/000808 WO2015102022A2 (en) 2013-12-31 2014-12-31 An improved process for the preparation of abiraterone acetate

Country Status (1)

Country Link
WO (1) WO2015102022A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105503992A (en) * 2016-01-22 2016-04-20 江苏联环药业股份有限公司 Preparation method of abiraterone acetate
CN107840866A (en) * 2016-09-20 2018-03-27 正大天晴药业集团股份有限公司 The preparation method of Abiraterone acetate
CN107236015A (en) * 2017-06-15 2017-10-10 甘肃兰药药业有限公司 A kind of Abiraterone acetate reduction impurity and preparation method thereof
CN111303234A (en) * 2020-02-28 2020-06-19 江西青峰药业有限公司 Abiraterone acetate monocrystal and preparation method thereof
CN111505148B (en) * 2020-04-29 2023-04-07 甘肃兰药药业有限公司 High performance liquid chromatography detection method for abiraterone acetate related substances
CN112125942B (en) * 2020-09-28 2021-12-14 湖南新合新生物医药有限公司 Synthetic method of abiraterone acetate and intermediate thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995009178A1 (en) * 1993-09-30 1995-04-06 British Technology Group Limited Synthesis of 17-(3-pyridyl) steroids
CN102816200A (en) * 2012-09-05 2012-12-12 中山大学 Method for preparing abiraterone acetate
CN103059091A (en) * 2012-11-22 2013-04-24 苏州雷纳药物研发有限公司 Method for preparing abiraterone acetate without heavy-metal residue

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995009178A1 (en) * 1993-09-30 1995-04-06 British Technology Group Limited Synthesis of 17-(3-pyridyl) steroids
CN102816200A (en) * 2012-09-05 2012-12-12 中山大学 Method for preparing abiraterone acetate
CN103059091A (en) * 2012-11-22 2013-04-24 苏州雷纳药物研发有限公司 Method for preparing abiraterone acetate without heavy-metal residue

Also Published As

Publication number Publication date
WO2015102022A2 (en) 2015-07-09

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