CN107488152B - 一种阿法替尼中间体及其合成方法 - Google Patents
一种阿法替尼中间体及其合成方法 Download PDFInfo
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- CN107488152B CN107488152B CN201610406740.4A CN201610406740A CN107488152B CN 107488152 B CN107488152 B CN 107488152B CN 201610406740 A CN201610406740 A CN 201610406740A CN 107488152 B CN107488152 B CN 107488152B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
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CN107488152A CN107488152A (zh) | 2017-12-19 |
CN107488152B true CN107488152B (zh) | 2020-12-29 |
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GB9314893D0 (en) * | 1993-07-19 | 1993-09-01 | Zeneca Ltd | Quinazoline derivatives |
JP2009529045A (ja) * | 2006-03-03 | 2009-08-13 | アベオ ファーマシューティカルズ, インコーポレイテッド | 7−アルキニル−4−アミノキナゾリンを合成する方法及び関連した中間体 |
CN102250075B (zh) * | 2010-05-21 | 2016-09-21 | 中国医学科学院药物研究所 | 2,4-二取代喹唑啉类化合物、及其制法和药物组合物与用途 |
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Denomination of invention: The invention relates to an afatinib intermediate and a synthetic method thereof Effective date of registration: 20211224 Granted publication date: 20201229 Pledgee: Industrial and Commercial Bank of China Limited Feixian sub branch Pledgor: SHANDONG NEW TIME PHARMACEUTICAL Co.,Ltd. Registration number: Y2021980016193 |
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Date of cancellation: 20221028 Granted publication date: 20201229 Pledgee: Industrial and Commercial Bank of China Limited Feixian sub branch Pledgor: SHANDONG NEW TIME PHARMACEUTICAL Co.,Ltd. Registration number: Y2021980016193 |
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Denomination of invention: An intermediate of alfatinib and its synthesis method Effective date of registration: 20221103 Granted publication date: 20201229 Pledgee: Industrial and Commercial Bank of China Limited Feixian sub branch Pledgor: SHANDONG NEW TIME PHARMACEUTICAL Co.,Ltd. Registration number: Y2022980020531 |