CN107474136B - 增强激动型抗体活性的抗体重链恒定区序列 - Google Patents

增强激动型抗体活性的抗体重链恒定区序列 Download PDF

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CN107474136B
CN107474136B CN201710429281.6A CN201710429281A CN107474136B CN 107474136 B CN107474136 B CN 107474136B CN 201710429281 A CN201710429281 A CN 201710429281A CN 107474136 B CN107474136 B CN 107474136B
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CN107474136A (zh
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李福彬
刘小波
张燕
赵英杰
石欢
张慧慧
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Shanghai Jiao Tong University
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Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2990885A1 (en) * 2015-06-30 2017-01-05 Sanford-Burnham Medical Research Institute Btla fusion protein agonists and uses thereof
WO2017211321A1 (zh) * 2016-06-08 2017-12-14 上海交通大学医学院 增强激动型抗体活性的抗体重链恒定区序列
JP7774283B2 (ja) * 2017-12-19 2025-11-21 ザ ロックフェラー ユニバーシティー エフェクター機能を改良したヒトIgGのFc領域改変体
CN111788227B (zh) * 2017-12-27 2025-02-25 百时美施贵宝公司 抗cd40抗体及其用途
CN109970856B (zh) 2017-12-27 2022-08-23 信达生物制药(苏州)有限公司 抗lag-3抗体及其用途
CN110144009B (zh) * 2018-02-14 2020-01-21 上海洛启生物医药技术有限公司 Cd47单域抗体及其用途
EP3887397A1 (en) * 2018-11-28 2021-10-06 Bristol-Myers Squibb Company Antibodies comprising modified heavy constant regions
TWI756621B (zh) * 2019-01-25 2022-03-01 大陸商信達生物製藥(蘇州)有限公司 新型雙特異性抗體分子以及同時結合pd-l1和lag-3的雙特異性抗體
WO2020207470A1 (zh) * 2019-04-10 2020-10-15 南开大学 抗cd40抗体及其用途
CN110981958B (zh) * 2019-08-23 2020-10-20 四川大学华西医院 一种pd-l1抗体
CN112592404B (zh) * 2019-09-20 2023-07-25 上海交通大学医学院 抗体活性改造及其筛选方法
KR20220109436A (ko) 2019-12-03 2022-08-04 에보텍 인터내셔널 게엠베하 인터페론-결합된 항원 결합 단백질 및 이의 용도
CN110862455B (zh) * 2019-12-03 2021-12-21 源道隆(苏州)医学科技有限公司 可结合cd47的多肽及其应用
JP7836088B2 (ja) * 2019-12-03 2026-03-26 上海交通大学医学院 FcγRIIB親和性が増強された抗体Fc領域
BR112022023989A2 (pt) 2020-05-26 2023-02-07 Boehringer Ingelheim Int Anticorpos anti-pd-1
CN114591428B (zh) * 2020-12-04 2024-05-28 上海交通大学医学院 抗Dsg1抗体及其应用
KR102671409B1 (ko) * 2021-03-02 2024-05-31 진화섭 Cd30을 발현하는 세포에 독성을 나타내는 재조합 단백질 및 이를 유효성분으로 포함하는 암의 치료용 약학적 조성물
CN118339300A (zh) * 2024-01-02 2024-07-12 江苏集萃药康生物科技股份有限公司 产生人源化抗体的动物模型及其构建方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060093600A1 (en) * 2001-11-09 2006-05-04 Abgenix, Inc. Antibodies to CD40
WO2015070972A1 (en) * 2013-11-12 2015-05-21 Atlab Pharma Human igg1 derived antibody with pro-apoptotic activity
CN104955844A (zh) * 2013-02-01 2015-09-30 瑞泽恩制药公司 包含嵌合恒定结构域的抗体
WO2015184099A1 (en) * 2014-05-28 2015-12-03 4-Antibody Ag Anti-gitr antibodies and methods of use thereof
WO2016081746A2 (en) * 2014-11-21 2016-05-26 Bristol-Myers Squibb Company Antibodies comprising modified heavy constant regions

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7388079B2 (en) * 2002-11-27 2008-06-17 The Regents Of The University Of California Delivery of pharmaceutical agents via the human insulin receptor
CN103172731A (zh) * 2004-07-15 2013-06-26 赞科股份有限公司 优化的Fc变体
JP5188804B2 (ja) * 2004-08-03 2013-04-24 トランステック ファーマ,インコーポレイティド Rage融合タンパク質及びその使用方法
KR20070090036A (ko) * 2004-12-22 2007-09-04 센토코 인코포레이티드 Glp-1 작용제, 조성물, 방법 및 용도
WO2007067828A2 (en) * 2005-10-24 2007-06-14 Centocor, Inc. Glp-2 mimetibodies, polypeptides, compositions, methods and uses
CA2759146C (en) * 2009-04-20 2017-06-13 Kyowa Kirin Co., Ltd. Agonist anti-cd40 antibody
CA2822366A1 (en) * 2010-12-23 2012-06-28 Janssen Biotech, Inc. Active protease-resistant antibody fc mutants
CN112812184A (zh) * 2011-02-25 2021-05-18 中外制药株式会社 FcγRIIb特异性Fc抗体
EP2537864B1 (en) * 2011-06-24 2019-08-07 Laboratoire Français du Fractionnement et des Biotechnologies Fc variants with reduced effector functions
JP6322411B2 (ja) * 2011-09-30 2018-05-09 中外製薬株式会社 複数の生理活性を有する抗原の消失を促進する抗原結合分子
SG10201805584YA (en) * 2012-02-24 2018-08-30 Chugai Pharmaceutical Co Ltd ANTIGEN-BINDING MOLECULE FOR PROMOTING DISAPPEARANCE OF ANTIGEN VIA FcγRIIB
US9890378B2 (en) * 2012-05-11 2018-02-13 Merck Sharp & Dohme Corp. Surface anchored light chain bait antibody display system
TW202237660A (zh) * 2012-08-24 2022-10-01 日商中外製藥股份有限公司 FcγRIIb特異性Fc區域變異體
AU2013337903B2 (en) * 2012-10-30 2018-08-16 Apexigen, Inc. Anti-CD40 antibodies and methods of use
SMT201800503T1 (it) * 2013-03-18 2018-11-09 Janssen Pharmaceuticals Inc Anticorpi anti-cd (ox40) umanizzati e loro usi
EP3099717B1 (en) * 2014-01-31 2019-03-27 Novartis AG Antibody molecules to tim-3 and uses thereof
CN106255704A (zh) * 2014-04-16 2016-12-21 Ucb生物制药私人有限公司 多聚体Fc蛋白
AU2015269415A1 (en) * 2014-06-05 2017-01-05 The Board Of Trustees Of The University Of Arkansas Antibody guided vaccines and methods of use for generation of rapid mature immune responses
MY189836A (en) * 2014-11-21 2022-03-11 Bristol Myers Squibb Co Antibodies against cd73 and uses thereof
BR112018010172A2 (pt) * 2015-11-19 2018-11-21 Bristol Myers Squibb Co anticorpos contra receptor de fator de necrose de tumor induzido por glicocorticoide (gitr) e usos dos mesmos
WO2017211321A1 (zh) * 2016-06-08 2017-12-14 上海交通大学医学院 增强激动型抗体活性的抗体重链恒定区序列
CN108623686A (zh) 2017-03-25 2018-10-09 信达生物制药(苏州)有限公司 抗ox40抗体及其用途
JP7836088B2 (ja) * 2019-12-03 2026-03-26 上海交通大学医学院 FcγRIIB親和性が増強された抗体Fc領域
CR20220582A (es) * 2020-05-01 2023-01-09 Bolt Biotherapeutics Inc Anticuerpos anti-dectina-2
CN114106174A (zh) * 2020-08-27 2022-03-01 苏州景涞医疗科技有限公司 低毒性抗ox40抗体、其药物组合物及应用

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060093600A1 (en) * 2001-11-09 2006-05-04 Abgenix, Inc. Antibodies to CD40
CN104955844A (zh) * 2013-02-01 2015-09-30 瑞泽恩制药公司 包含嵌合恒定结构域的抗体
WO2015070972A1 (en) * 2013-11-12 2015-05-21 Atlab Pharma Human igg1 derived antibody with pro-apoptotic activity
WO2015184099A1 (en) * 2014-05-28 2015-12-03 4-Antibody Ag Anti-gitr antibodies and methods of use thereof
WO2016081746A2 (en) * 2014-11-21 2016-05-26 Bristol-Myers Squibb Company Antibodies comprising modified heavy constant regions

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Engineered antibody Fc variant with selectively enhanced FcγRIIb binding over both FcγRIIa(R131) and FcγRIIa(H131);Mimoto,F.等;《Protein Engineering Design & Selection Peds》;20130605;第26卷(第10期);第589-598页 *
Inhibition of B cell receptor-mediated activation of primary human B cells by coengagement of CD19 and FcγRIIb with Fc-engineered antibodies;Chu S.Y.等;《Molecular Immunology》;20080808;第45卷(第15期);第3926-3933页 *
Optimization of Fc-mediated effector functions of monoclonal antibodies;Strohl W R.等;《Current Opinion in Biotechnology》;20091104;第20卷(第6期);第685-691页 *
Therapeutic Activity of Agonistic, Human Anti-CD40 Monoclonal Antibodies Requires Selective FcγR Engagement;Rony Dahan等;《Cancer Cell》;20160613;第29卷(第6期);第820-831页 *

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JP2024112978A (ja) 2024-08-21
JP2019528082A (ja) 2019-10-10
WO2017211321A1 (zh) 2017-12-14
US12145993B2 (en) 2024-11-19
JP2021143186A (ja) 2021-09-24
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