CN107469039A - A kind of Chinese medicine composition for being used to treat gasteremphraxis - Google Patents
A kind of Chinese medicine composition for being used to treat gasteremphraxis Download PDFInfo
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- CN107469039A CN107469039A CN201710755848.9A CN201710755848A CN107469039A CN 107469039 A CN107469039 A CN 107469039A CN 201710755848 A CN201710755848 A CN 201710755848A CN 107469039 A CN107469039 A CN 107469039A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/24—Mucus; Mucous glands; Bursa; Synovial fluid; Arthral fluid; Excreta; Spinal fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/235—Foeniculum (fennel)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/89—Cyperaceae (Sedge family)
- A61K36/8905—Cyperus (flatsedge)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
Abstract
The present invention discloses a kind of Chinese medicine composition for being used to treat gasteremphraxis, and the Chinese medicine composition according to the traditional Chinese medicine of lower parts by weight by forming：15 20 parts of Radix Codonopsis, 15 20 parts of the bighead atractylodes rhizome, 10 20 parts of rhizoma zingiberis, 10 20 parts of rhizoma cyperi, 35 parts of root tuber of aromatic turmeric, 5 15 parts of fennel seeds, 8 15 parts of excrementum pteropi, 3 10 parts of kamuning, 15 20 parts of ergcibe obtusifolia.The present invention is based on the understanding and principle of reatment to gasteremphraxis symptom mechanism, using the treatment gasteremphraxis Chinese medicine composition of above-mentioned formula, using directly oral method, altogether the effect of long memorial liver and qi, strengthening the spleen and stomach, warming spleen and stomach for dispelling cold, promoting the circulation of qi dissipate-swelling, the treatment to gasteremphraxis, which reaches, treats both principal and secondary aspect of disease；Prescription of the present invention prepares simplicity, medicine source is wide, cost is low.
Description
Technical field
The invention belongs to tcm field, in particular to a kind of Chinese medicine composition for being used to treat gasteremphraxis.
Background technology
The reason for gasteremphraxis, mainly includes：1st, diet is unhygienic；2nd, amount of drinking water is very little or roughage input is made very little
Into constipation flatulence；3rd, daily life system is abnormal.It is also possible at regular time and quantity, cause enteron aisle excessively hungry or be excessively satiated with food, cause
Enteron aisle remarkable action, can making stomach and intestine for a long time, over-burden；That the 4th, eats is too greasy, causes enteron aisle nondigestible；5th, eat too
It hurry up.Chewing can be made not in place, cause digestive juice and food to be thoroughly mixed, thus sufficiently digestion point can not be carried out
Solution, is damaged to enteron aisle；6th, the excessive physiological function that directly affects of pressure is exactly function of intestinal canal exception.Such as hyperhydrochloria, slow down
Wriggling accelerates wriggling etc..Hyperhydrochloria can damage gastric mucosa, and accelerating wriggling can cause to suffer from diarrhoea again and again, and slowing down wriggling can cause
Abdominal distension；7th, disease causes：Clinically superficial gastritis, duodenal ulcer, acute gastritis etc., all based on gasteremphraxis.
The traditional Chinese medical science thinks stomach receiving food and drink, the diastole of stomach and spasm, completes the digestion of food.Conversely, gastric diastole is lacked of proper care with spasm,
Expansion is more than spasm, and gasteremphraxis is into.Why dilatation of the stomach is without spasm, and internal organs hurt is basis.
The method for the treatment of gasteremphraxis includes at present：Ease off the pressure, keep sufficient sleep, frequent defaecation etc., but these methods exist
It can not be taken effect in short time, it is necessary to which long-term adjustment could eliminate gasteremphraxis, and can not effect a radical cure.Although the Western medicine sold on the market takes effect
It hurry up, but be unable to reach the function of regulation stomach, be equally unable to reach the purpose of radical cure gasteremphraxis.
The content of the invention
The purpose of the present invention is the defects of overcoming conventional medicament, there is provided a kind of evident in efficacy, quality is easily controlled, stability
The good Chinese medicine composition for being used to treat gasteremphraxis.
The present invention is achieved through the following technical solutions：A kind of Chinese medicine composition for being used to treat gasteremphraxis, the Chinese traditional medicine composition
Thing according to the traditional Chinese medicine of lower parts by weight by forming：Radix Codonopsis 15-20 parts, bighead atractylodes rhizome 15-20 parts, rhizoma zingiberis 10-20 parts, rhizoma cyperi 10-20
Part, root tuber of aromatic turmeric 3-5 parts, fennel seeds 5-15 parts, excrementum pteropi 8-15 parts, kamuning 3-10 parts, ergcibe obtusifolia 15-20 parts；
A kind of bulk drug pharmacology for being used to treat the Chinese medicine composition of gasteremphraxis of the present invention：
Radix Codonopsis：It is mild-natured, it is sweet.Tonifying middle-Jiao and Qi, clearing heat and detoxicating, expelling phlegm and arresting coughing.For spleen eating less loose stool, weakness of limbs, palpitaition,
Shortness of breath, dry, spontaneous perspiration, prolapse of the anus, the prolapse of uterus.
The bighead atractylodes rhizome：It is warm-natured, it is sweet, bitter.Returns spleen warp, stomach.It is invigorating the spleen, QI invigorating, eliminate dampness and have diuretic effect, hidroschesis, antiabortive.Belong under qi-restoratives medicine
Belong to the Qi-tonifying drug of classification.
Root tuber of aromatic turmeric：Nature and flavor are pungent, bitter, tremble with fear.Return liver, the heart, lung channel.Promoting blood circulation and stopping pain, promoting qi circulation and removing obstruction in the collateral, clear away heart-fire cool blood, normalizing gallbladder to cure jaundice.
Fennel seeds：It is warm-natured, acrid flavour.Return liver warp, the spleen channel, stomach, kidney channel.Cold-dispelling pain-relieving, regulating qi-flowing for harmonizing stomach.Belong to drugs for dispelling internal cold.
Excrementum pteropi：Warm-natured, taste is salty, sweet.Return liver warp.Promoting blood circulation and stopping pain, removing blood stasis and hemostasis, disperse accumulations removing toxic substances.Belong under drug for invigorating blood circulation and eliminating stasis
Belong to the blood-activating analgesic of classification.
Kamuning：It is warm-natured, acrid flavour, slight bitter.Return liver warp, stomach.Promoting qi circulation and relieving pain, promoting blood circulation to remove blood stasis.Belong to qi-regulating drug.
Ergcibe obtusifolia：It is warm-natured, acrid flavour.Return stomach, the spleen channel, Liver Channel.Dispelling wind and eliminating dampness, swelling and pain relieving.Belong to medicine for rheumatism subordinate point
The wind-damp-dispelling and cold-dissipating medicinal of class.
Rhizoma zingiberis：Property heat, acrid flavour.Returns spleen warp, stomach, the heart channel of Hang-Shaoyin, kidney channel, lung channel.Warming spleen and stomach for dispelling cold, Back to Yang Tongmai, eliminating dampness dissolving phlegm.
Belong to drugs for dispelling internal cold.
Rhizoma cyperi：It is mild-natured, acrid flavour, slight bitter, micro-sweet.Return liver warp, tri-jiao channel.Promoting qi circulation and removing obstruction in the collateral, menstruction regulating and pain relieving.Belong to qi-regulating drug.
For optimize medicine effect of drugs, further determine that, 18 parts of Radix Codonopsis, 15 parts of the bighead atractylodes rhizome, 12 parts of rhizoma zingiberis, 15 parts of rhizoma cyperi,
5 parts of root tuber of aromatic turmeric, 10 parts of fennel seeds, excrementum pteropi 8- parts, 5 parts of kamuning, 15 parts of ergcibe obtusifolia.
To optimize the effect of drugs of medicine, further determine that, weigh 15 parts of Radix Codonopsis, 17 parts of the bighead atractylodes rhizome, 15 parts of rhizoma zingiberis, rhizoma cyperi 10
Part, 3 parts of root tuber of aromatic turmeric, 5 parts of fennel seeds, 10 parts of excrementum pteropi, 6 parts of kamuning, 15 parts of ergcibe obtusifolia.
To optimize the effect of drugs of medicine, further determine that, the Chinese medicine composition can be prepared into pharmaceutically acceptable
Formulation.
For optimize medicine effect of drugs, further determine that, pharmaceutically acceptable formulation be selected from decoction, pill, pulvis,
Capsule, tablet or electuary.
The present invention compared with prior art, has the advantage that and had the beneficial effect that：
The present invention is based on the understanding and principle of reatment to gasteremphraxis symptom mechanism, obtained by being prepared using above-mentioned formula and method
Treatment gasteremphraxis Chinese medicine composition, mutual assistant is being used through dialectical compatibility using directly oral method, its drug component
Help, altogether the effect of long memorial liver and qi, strengthening the spleen and stomach, warming spleen and stomach for dispelling cold, promoting the circulation of qi dissipate-swelling, the treatment to gasteremphraxis, which reaches, treats both principal and secondary aspect of disease；This
Invention prescription prepares simplicity, medicine source is wide, cost is low.
Embodiment
The present invention is described in further detail with reference to embodiment, but the implementation of the present invention is not limited to this,
Without departing from the idea case in the present invention described above, according to ordinary skill knowledge and customary means, various replace is made
Change and change, all should be included within the scope of the invention.
Embodiment 1：
It is used for the Chinese medicine composition for treating gasteremphraxis described in the present embodiment, the Chinese medicine composition according to the Chinese medicine of lower parts by weight by matching somebody with somebody
System forms：Radix Codonopsis 15-20 parts, bighead atractylodes rhizome 15-20 parts, rhizoma zingiberis 10-20 parts, rhizoma cyperi 10-20 parts, root tuber of aromatic turmeric 3-5 parts, fennel seeds 5-15
Part, excrementum pteropi 8-15 parts, kamuning 3-10 parts, ergcibe obtusifolia 15-20 parts.
The preparation method of medicine of the present invention, comprises the following steps：
（1）By above-mentioned whole Chinese medicine material medicines, to be soaked 30 minutes with clear water or pure water in advance, water consumption for immersion is 0.8 ~
1.0L。
（2）Chinese medicine material medicine after immersion and its liquid medicine of immersion are added in decocting container, capping decocts jointly.
（3）Decocting container herb liquid is seethed with excitement with high heat, reuse slow fire and boil 10-15 minutes, 2 need to be stirred when boiling medicine
~ 3 times.
（4）After the completion of decoction, add proper amount of clear water or pure water not to have medicine, carry out second and decoct, decoct duration and degree of heating method
Ibid, decocting time 5-10 minutes.
（5）Decoction is filtered out, it is endo-medicine to obtain decoction.
Above-mentioned decocting container is marmite, enamel ware or stainless steel, avoids and uses ironware.
The application method of medicine of the present invention：It is directly for oral administration.
Embodiment 2：
The medicine of gasteremphraxis is treated described in the present embodiment, is represented with parts by weight, the Chinese medicine composition is by according in lower parts by weight
Medicine is formulated：18 parts of Radix Codonopsis, 15 parts of the bighead atractylodes rhizome, 12 parts of rhizoma zingiberis, 15 parts of rhizoma cyperi, 5 parts of root tuber of aromatic turmeric, 10 parts of fennel seeds, excrementum pteropi 8- parts,
5 parts of kamuning, 15 parts of ergcibe obtusifolia.
Embodiment 3：
The medicine of gasteremphraxis is treated described in the present embodiment, is represented with parts by weight, the Chinese medicine composition is by according in lower parts by weight
Medicine is formulated：15 parts of Radix Codonopsis, 17 parts of the bighead atractylodes rhizome, 15 parts of rhizoma zingiberis, 10 parts of rhizoma cyperi, 3 parts of root tuber of aromatic turmeric, 5 parts of fennel seeds, 10 parts of excrementum pteropi,
6 parts of kamuning, 15 parts of ergcibe obtusifolia.
Embodiment 4：
The medicine of gasteremphraxis is treated described in the present embodiment, the Chinese medicine composition can be prepared into pharmaceutically acceptable formulation.Pharmacy
Acceptable formulation is selected from decoction, pill, pulvis, capsule, tablet or electuary.
Toxicology test：
Acute toxicity test：
Experimental observation, because LD50 can not be measured, therefore the measure of maximum dosage-feeding is carried out.Chinese medicine compound prescription prepared by embodiment 1
Mixture is dissolved in sterile saline, is configured to solution gavage mouse, is as a result shown, is given birth to medicine maximum administration concentration 9.65
Medicine/ml, for maximum administered volume 50ml/kg in being administered twice in 24 hours to mouse stomach, mouse maximum dosage-feeding is 763.25g
Crude drug/kg, animal do not occur adverse reaction and death, each internal organs no abnormality seen of anatomic observation.
Long term toxicity test
SD rats 80 are applied in this experiment, and Chinese medicine compound prescription mixture prepared by embodiment 1 is dissolved in sterile saline, configuration
Into solution gavage, if control group and 24g, 35g, 49g crude drug/kg dosage groups, continuous gavage is administered 12 weeks, observes in the present invention
Influence of the drug composition to animal indices.Result of the test shows that successive administration 12 weeks, Chinese medicine composition of the invention is to big
The body weight of mouse, food ration, peripheral hemogram, clotting time, electrocardiogram, organ index etc. have no significant effect.Blood biochemical 12
Item index determining result, 12 weeks low dose group BiLi values of administration are higher than control group（P<0.05).Low dose group, middle dose group TP values
Higher than control group（P<0.05), but within normal physiologic range, other indexs no significant difference compared with control group.Recover
Phase each administration group indices measured value and the more equal no significant difference of control group.Each internal organs gross examination of skeletal muscle no abnormality seen of each group.
The clinical statisticses data of various gasteremphraxis patients is directed to using medicine of the present invention：
By the Clinical practice of 200 patients, wherein male patient 127, female patient 73, medication age object 20 ~ 70 years old.Wherein
It is minimum 21 years old, it is maximum 67 years old.Slight gasteremphraxis disease 42, moderate gasteremphraxis disease 72, severe gasteremphraxis disease 36.
Model case：
Case 1：Mr. Wang, male, 61 years old.Medical readme：Gasteremphraxis recurrent exerbation for many years, as weather gradually turns cold, just starts gasteremphraxis,
Weather gradually warms up, and gasteremphraxis mitigates.Closely over the past half year, aggravation takes a variety of western medicines, and effect is not notable.Take this
After 3 courses for the treatment of of medicament prepared by the Chinese medicine composition of invention, feel that gasteremphraxis is alleviated, mental attitude is obviously improved.Continue to take 3
The course for the treatment of, symptom disappear, and cure.
Case 2：Zhang, female, 21 years old.Medical readme：Occurred Abdeminal pain sense before one month suddenly, nausea, vomiting, appetite
It is depressed.After oral Omeprazole Enteric-coated Tablets and amoxil capsule, the state of an illness can temporarily get alleviation, after drug withdrawal again repeatedly.Clothes
3 courses for the treatment of of medicament prepared with the Chinese medicine composition of the present invention, gasteremphraxis are clearly better, appetite increase.Continue after taking 5 courses for the treatment of, respectively
Symptom is disappeared, and gastrocopy is shown normally, is cured.
Case 3：Male, 36 years old.Medical history：Patient must have stomach trouble 5 years, and digestion power is poor, every time after edible rich food dish,
Often there are the uncomfortable diseases such as gasteremphraxis, the state of mind is deteriorated, and loss of appetite, stool has some setbacks, sour regurgitation, belch etc..Take a variety of Western medicine
Treatment, effect be not notable.After taking 6 courses for the treatment of of medicament of Chinese medicine composition preparation of the present invention, feel that gasteremphraxis is alleviated, spirit
Looks are obviously improved.Continue to take 3 courses for the treatment of, symptom disappears, and cures.
It is described above, be only presently preferred embodiments of the present invention, any formal limitation not done to the present invention, it is every according to
Any simply modification, the equivalent variations made according to the technical spirit of the present invention to above example, each fall within the protection of the present invention
Within the scope of.
Claims (5)
1. a kind of Chinese medicine composition for being used to treat gasteremphraxis, it is characterised in that the Chinese medicine composition is by according to lower parts by weight
Traditional Chinese medicine forms：Radix Codonopsis 15-20 parts, bighead atractylodes rhizome 15-20 parts, rhizoma zingiberis 10-20 parts, rhizoma cyperi 10-20 parts, root tuber of aromatic turmeric 3-5 parts, fennel seeds
5-15 parts, excrementum pteropi 8-15 parts, kamuning 3-10 parts, ergcibe obtusifolia 15-20 parts.
A kind of 2. Chinese medicine composition for being used to treat gasteremphraxis according to claim 1, it is characterised in that the Chinese traditional medicine composition
Thing according to the traditional Chinese medicine of lower parts by weight by forming：18 parts of Radix Codonopsis, 15 parts of the bighead atractylodes rhizome, 12 parts of rhizoma zingiberis, 15 parts of rhizoma cyperi, 5 parts of root tuber of aromatic turmeric are small
10 parts of fennel, excrementum pteropi 8- parts, 5 parts of kamuning, 15 parts of ergcibe obtusifolia.
A kind of 3. Chinese medicine composition for being used to treat gasteremphraxis according to claim 1, it is characterised in that the Chinese traditional medicine composition
Thing according to the traditional Chinese medicine of lower parts by weight by forming：15 parts of Radix Codonopsis, 17 parts of the bighead atractylodes rhizome, 15 parts of rhizoma zingiberis, 10 parts of rhizoma cyperi, 3 parts of root tuber of aromatic turmeric are small
5 parts of fennel, 10 parts of excrementum pteropi, 6 parts of kamuning, 15 parts of ergcibe obtusifolia.
4. a kind of Chinese medicine composition for being used to treat gasteremphraxis according to claim any one of 1-3, it is characterised in that described
Chinese medicine composition can be prepared into pharmaceutically acceptable formulation.
5. a kind of Chinese medicine composition for being used to treat gasteremphraxis according to claim 4, it is characterised in that pharmaceutically acceptable
Formulation is selected from decoction, pill, pulvis, capsule, tablet or electuary.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104173906A (en) * | 2014-09-18 | 2014-12-03 | 梁成 | Traditional Chinese medicine composition for treating gastrectasia |
| CN105878933A (en) * | 2016-05-26 | 2016-08-24 | 张晓燕 | Traditional Chinese medicine composition for treating gastrectasia |
-
2017
- 2017-08-29 CN CN201710755848.9A patent/CN107469039A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104173906A (en) * | 2014-09-18 | 2014-12-03 | 梁成 | Traditional Chinese medicine composition for treating gastrectasia |
| CN105878933A (en) * | 2016-05-26 | 2016-08-24 | 张晓燕 | Traditional Chinese medicine composition for treating gastrectasia |
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