CN108066443A - A kind of drug and preparation method for promoting acleistocardia border cell growth - Google Patents
A kind of drug and preparation method for promoting acleistocardia border cell growth Download PDFInfo
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Abstract
The present invention provides a kind of drug for promoting acleistocardia border cell growth and preparation method thereof,By 1~4 part of Radix Glycyrrhizae,Twist with the fingers 5~10 parts of grass in ground,5~10 parts of Radix Notoginseng,2~8 parts of cassia seed,6~12 parts of lycopodium calvatum,Windproof 10~15 parts,1~6 part of Radix Astragali,15~20 parts of Asian puccoon,4~10 parts of the root of bidentate achyranthes,2~8 parts of Rhizoma Chuanxiong,12~18 parts of corydalis tuber,6~14 parts of the radix paeoniae rubrathe,2~6 parts of dipsacus root,18~22 parts of Radix Salviae Miltiorrhizae,2~6 parts of safflower,1~4 part of peach kernel,0.01~0.1 part of Western medicine,Through decocting,Extraction,It is mixed to get a kind of drug for promoting oval foramen border cell growth,Drug of the present invention, which has, promotes foramen ovale of heart border cell growth,Realize that oval foramen is voluntarily closed,It is small with treatment wound,It is dangerous small,Expense is low,Recover the characteristics of fast,Drug is simple with preparation method,Processing cost is low,The characteristics of without any side effects.
Description
Technical field
The invention belongs to medical domains, and in particular to a kind of drug and preparation for acleistocardia border cell growth
Method.
Background technology
Oval foramen is the required life channel of development of fetus, and the throat aspirate of parent is transported to a left side by fetus by the passage
Ventricle is distributed to whole body to provide the required oxygen of development of fetus and nutrition for it.After fetal birth, left atrial pressure liter
Height, oval foramen realize functional closure, and anatomy closure is reached after 1 year, if the oval foramen of three years old or more child is still not closed,
Then become acleistocardia (PFO).
Under normal circumstances, PFO is without clinical meaning, on the contrary, valve of foramen ovale can stop the flat left to right shunt of aqueous humor.When right room
Pressure is gradually risen with successional right-left shunt, left point adjoint of dextrad of of short duration right room pressure rise after positivity ventilation pressure release
Between stream and atrium during the adjoint of short duration right-left shunt of periodic pressure difference, it can cause venous system thrombus or right room blood
Bolt causes body circulation arterial embolism, i.e. crossed embolism via the oval foramen of patent.Intracardiac passages of the PFO as crossed embolism, hair
Wave important function.The morbidity that the brains such as PFO and hidden source property cerebral embolism, antimigraine, decompression sickness mend ischemic disease is had been accepted as at present
By substantial connection.Therefore, realize the closure of acleistocardia patient, there is very important meaning to clinical medicine.
PFO is generated in the secondary septum (abbreviation SS) of heart.In heart, the blood pressure in normal heart atrium sinistrum is higher than the heart
Blood pressure in dirty atrium dextrum, this causes the septum primum (abbreviation SP) of oval foramen to be closed.It however, ought be in case of emergency (as coughed
Or across position) when being more than the blood pressure in heart atrium sinistrum, SP is opened the blood pressure in heart atrium dextrum towards the atrium sinistrum one side of heart,
Blood is caused to flow to the atrium sinistrum one side (artery) of heart from the atrium dextrum one side (vein) of heart.If in this case,
Contain fibrin ferment in blood, then fibrin ferment is transported to artery from vein, and flows to atrium dextrum from the atrium sinistrum of heart, then
Into sustainer and into brain, this this may result in antimigraine or apoplexy.
At present, it is directly perceived to include percutaneous catheter insertion art closure, the heart of body outer circulation for the therapy of acleistocardia
Operation and medicinal treatment (aspirin, neodicoumarin anticoagulant etc.).Drug therapy generally includes oral anticoagulant or anti-blood is small
Plate agent, these treatments can cause some side effects, if drug therapy is improper will to implement open heart operation, for example, by suture
To be closed PFO.Similar to other opening operative treatments, this operation is height intrusive mood and dangerous, it is necessary to general anesthesia, and
And very long rehabilitation course can be caused.Percutaneous catheter insertion art, which is closed, to be radical treatment and the risk of recurrence is not present, but general
Closing device based on using to be closed the disc diaphragm of defect or take aim to determine component come clamp SP and SS, and they are stayed in
Patient's body.Membrane and take aim at that determine component be foreign bodies, fibrin ferment is easily deposited on.When fibrin ferment is deposited on positioned at a heart left side
When in the disc diaphragm of atrium one side, fibrin ferment flow further downstream can cause apoplexy or can make to have the SP of thin-walled to rupture.Separately
Outside, either percutaneous catheter insertion art be closed or the heart of body outer circulation intuitively operation is dangerous all there are traumatic big
The characteristics of height, medical expense is expensive, and treatment cycle is long.
The content of the invention
In order to overcome above-mentioned prior art defect, it is an object of the invention to provide a kind of drugs for treating acleistocardia
And preparation method thereof and application method.
In order to solve the above-mentioned technical problem, the present invention takes following technical solution：A kind of promotion acleistocardia edge
The drug of cell growth, weight composition include：1~4 part of Radix Glycyrrhizae, twist with the fingers grass 5~10 parts, 5~10 parts of Radix Notoginseng, cassia seed 2~8
Part, 6~12 parts of lycopodium calvatum, 10~15 parts windproof, 1~6 part of Radix Astragali, 15~20 parts of Asian puccoon, 4~10 parts of the root of bidentate achyranthes, 2~8 parts of Rhizoma Chuanxiong,
12~18 parts of corydalis tuber, 6~14 parts of the radix paeoniae rubrathe, 2~6 parts of dipsacus root, 18~22 parts of Radix Salviae Miltiorrhizae, 2~6 parts of safflower, 1~4 part of peach kernel, Western medicine
0.01~0.1 part.
Further, optimum weight part composition of the drug is：3 parts of Radix Glycyrrhizae, twist with the fingers grass 8 parts, 8 parts of Radix Notoginseng, cassia seed 6
Part, 9 parts of lycopodium calvatum, 13 parts windproof, 3 parts of Radix Astragali, 17 parts of Asian puccoon, 7 parts of the root of bidentate achyranthes, 5 parts of Rhizoma Chuanxiong, 15 parts of corydalis tuber, 10 parts of the radix paeoniae rubrathe, river
4 parts disconnected, 20 parts of Radix Salviae Miltiorrhizae, 4 parts of safflower, 3 parts of peach kernel, 0.05 part of Western medicine.
Further, the parts by weight composition of the drug is：1 part of Radix Glycyrrhizae, twist with the fingers grass 10 parts, 5 parts of Radix Notoginseng, 8 parts of cassia seed,
12 parts of lycopodium calvatum, 10 parts windproof, 2 parts of Radix Astragali, 15 parts of Asian puccoon, 4 parts of the root of bidentate achyranthes, 8 parts of Rhizoma Chuanxiong, 16 parts of corydalis tuber, 6 parts of the radix paeoniae rubrathe, dipsacus root 2
Part, 22 parts of Radix Salviae Miltiorrhizae, 2 parts of safflower, 1 part of peach kernel, 0.1 part of Western medicine.
Further, the parts by weight composition of the drug is：4 parts of Radix Glycyrrhizae, twist with the fingers grass 6 parts, 8 parts of Radix Notoginseng, 4 parts of cassia seed,
6 parts of lycopodium calvatum, 10 parts windproof, 6 parts of Radix Astragali, 18 parts of Asian puccoon, 10 parts of the root of bidentate achyranthes, 6 parts of Rhizoma Chuanxiong, 12 parts of corydalis tuber, 14 parts of the radix paeoniae rubrathe, dipsacus root
6 parts, 18 parts of Radix Salviae Miltiorrhizae, 4 parts of safflower, 4 parts of peach kernel, 0.01 part of Western medicine.
The preparation method step of the present invention is as follows：
Step S01, by Radix Glycyrrhizae, twist with the fingers grass, Radix Notoginseng, cassia seed, lycopodium calvatum raw material and be mixed to form the first raw material；By it is windproof,
Radix Astragali, Asian puccoon, the root of bidentate achyranthes, Rhizoma Chuanxiong, corydalis tuber raw material are mixed to form the second raw material；By the radix paeoniae rubrathe, dipsacus root, Radix Salviae Miltiorrhizae, safflower, peach kernel raw material
It is mixed to form the 3rd raw material；
In above-mentioned first raw material, Radix Glycyrrhizae and Radix Notoginseng have effects that Huoxue San " blood, and adding for grass, cassia seed and lycopodium calvatum is twisted with the fingers on ground
Entering so that Huoxue San " blood effect of Radix Glycyrrhizae and Radix Notoginseng is more notable so that border cell grows faster, in addition, lycopodium calvatum
Windproof cold extermination and dehumidification swelling act on so that the fresh surface of a wound faster heals；
In above-mentioned second raw material, Asian puccoon, the root of bidentate achyranthes, Rhizoma Chuanxiong and corydalis tuber have effects that promoting blood circulation, promote breath and open depression, windproof
Addition with Radix Astragali is beneficial to the more preferable performance of Asian puccoon, the root of bidentate achyranthes, Rhizoma Chuanxiong and corydalis tuber promoting blood circulation, promote breath and open depression effect, into one
Step promotes the growth of oval foramen border cell, and wound is made faster to heal, and has the function that oval foramen is closed.It is in addition, windproof and yellow
Stilbene has effects that QI invigorating wind-dispelling, is conducive to the recovery of the constitution after patient trauma.
In above-mentioned 3rd raw material, dipsacus root, Radix Salviae Miltiorrhizae, safflower and peach kernel have effects that adjust blood vessels, cool blood dissipates the stasis of blood, and the radix paeoniae rubrathe adds
Enter can guarantee that dipsacus root, Radix Salviae Miltiorrhizae, safflower and peach kernel tune blood vessels, stablizing for cool blood dissipates the stasis of blood effect play, promote oval foramen border cell
Faster grow.In addition, the radix paeoniae rubrathe has effects that the row stasis of blood, detumescence and analgesic, the healing of patient wound position can be accelerated, it is real as early as possible
The closure of existing acleistocardia.
First raw material is added in vacuum extraction tank, adds the 5-8 times of ethyl alcohol measured by step S02, when refluxing extraction 1-2 is small,
It repeats 2-5 times, and the extracting solution obtained every time is merged and is filtered, form the first extracting solution；Second raw material is added in into water and impregnates 1-2
Hour, it decocts and filters, form the second extracting solution；3rd raw material is decocted and filtered, alcohol is added to make its precipitation, filters to obtain supernatant
Liquid forms the 3rd extracting solution；
Distinct methods effective component extracting, the first raw material is respectively adopted in above-mentioned first raw material, the second raw material and the 3rd raw material
It is extracted using ethyl alcohol, this method can extract the lipophilic composition for being insoluble in water, and extraction time is short, and water-solubility impurity is few.Second is former
Material mainly obtains hydrophilic composition in Chinese herbal medicine using decocting cooking method.3rd extracting solution uses alcohol extracting after being decocted using first water
Method is obtaining the laggard onestep extraction lipophilicity of aqueous soluble active constituent, the active ingredient in raw material is made to play to the greatest extent
Out.
Step S03 mixes the first extracting solution with the second extracting solution, when heating 1-2 is small, when temperature is 60 DEG C near, then
3rd extracting solution is entered, when continuation heating stirring 1 is small, treats that temperature is cooled to 40 DEG C and is separately added into clopidogrel, vitamin C
Part, aspirin.
Clopidogrel and aspirin can inhibit platelet aggregation, the incidence for reducing ischemic event, in traditional Chinese medicine ingredients
Clopidogrel and aspirin are added in, while oval foramen border cell growth is promoted, ensures the normal operation of heart, avoids
The generation of the angiocardiopathies such as thrombus makes closing course more safe and effective, and ascorbic addition can ensure clopidogrel and Ah
The performance of department woods effect, improves patient's immunity, promotes to recover faster.
Further, the adition process of step S03 Chinese and Western medicines is as follows：First plus clopidogrel, heating stirring is until temperature liter
To 80 DEG C, aspirin is added, treats that temperature is cooled to 40 DEG C, adds vitamin C.
Further, the adition process of step S03 Chinese and Western medicines is as follows：First plus aspirin, heating stirring is until temperature liter
To 80 DEG C, clopidogrel is added, treats that temperature is cooled to 40 DEG C, adds vitamin C.
Further, the adition process of step S03 Chinese and Western medicines is as follows：Clopidogrel, vitamin C, aspirin are added in
In mixed liquor, heating stirring.
The application method of the drug of the present invention, its step are as follows：
Step S01 takes the method through femoral venous puncture, is manufactured on the secondary septum and septum primum of foramen ovale of heart patent
The fresh surface of a wound；
Step S02, it is postoperative 1 it is small when after take the drug, three times a day, a month as a treatment course.
It is an advantage of the invention that：
The drug of the present invention combines medicament for Chinese and Western, and western medicine composition is added on the basis of Chinese medicine, makes curative effect rapider, medicine
Side is cheap and easily-available, preparation process is simple, processing cost is low, evident in efficacy, without any side effects.Acleistocardia is treated with it
Patient, have wound is small, patient suffering is low, danger is small, medical expense is low, oval foramen completely by autologous tissue reparation, in vivo
Foreign remains, no adverse consequences.
Specific embodiment
Specific embodiments of the present invention are given below, for being described in further detail to the present invention.
Experimental method in following embodiments is conventional method unless otherwise specified.Medicine used in following embodiments
Material raw material, reagent material etc. unless otherwise specified, are commercially available products.
Embodiment 1
A kind of drug for promoting acleistocardia border cell growth
Raw material object forms：(unit：g)
Radix Glycyrrhizae 300, twist with the fingers grass 800, Radix Notoginseng 800, cassia seed 600, lycopodium calvatum 900, windproof 1300, Radix Astragali 300, Asian puccoon
1700th, the root of bidentate achyranthes 700, Rhizoma Chuanxiong 500, corydalis tuber 1500, the radix paeoniae rubrathe 1000, dipsacus root 400, Radix Salviae Miltiorrhizae 2000, safflower 400, peach kernel 300.
It is prepared via a method which：
Step S01, by Radix Glycyrrhizae, twist with the fingers grass, Radix Notoginseng, cassia seed, lycopodium calvatum raw material and be mixed to form the first raw material；By it is windproof,
Radix Astragali, Asian puccoon, the root of bidentate achyranthes, Rhizoma Chuanxiong, corydalis tuber raw material are mixed to form the second raw material；By the radix paeoniae rubrathe, dipsacus root, Radix Salviae Miltiorrhizae, safflower, peach kernel raw material
It is mixed to form the 3rd raw material；
In above-mentioned first raw material, Radix Glycyrrhizae and Radix Notoginseng have effects that Huoxue San " blood, and adding for grass, cassia seed and lycopodium calvatum is twisted with the fingers on ground
Entering so that Huoxue San " blood effect of Radix Glycyrrhizae and Radix Notoginseng is more notable so that border cell grows faster, in addition, lycopodium calvatum
Windproof cold extermination and dehumidification swelling act on so that the fresh surface of a wound faster heals；
In above-mentioned second raw material, Asian puccoon, the root of bidentate achyranthes, Rhizoma Chuanxiong and corydalis tuber have effects that promoting blood circulation, promote breath and open depression, windproof
Addition with Radix Astragali is beneficial to the more preferable performance of Asian puccoon, the root of bidentate achyranthes, Rhizoma Chuanxiong and corydalis tuber promoting blood circulation, promote breath and open depression effect, into one
Step promotes the growth of oval foramen border cell, and wound is made faster to heal, and has the function that oval foramen is closed.It is in addition, windproof and yellow
Stilbene has effects that QI invigorating wind-dispelling, is conducive to the recovery of the constitution after patient trauma.
In above-mentioned 3rd raw material, dipsacus root, Radix Salviae Miltiorrhizae, safflower and peach kernel have effects that adjust blood vessels, cool blood dissipates the stasis of blood, and the radix paeoniae rubrathe adds
Enter can guarantee that dipsacus root, Radix Salviae Miltiorrhizae, safflower and peach kernel tune blood vessels, stablizing for cool blood dissipates the stasis of blood effect play, promote oval foramen border cell
Faster grow.In addition, the radix paeoniae rubrathe has effects that the row stasis of blood, detumescence and analgesic, the healing of patient wound position can be accelerated, it is real as early as possible
The closure of existing acleistocardia.
First raw material is added in vacuum extraction tank, adds the 5-8 times of ethyl alcohol measured by step S02, when refluxing extraction 1-2 is small,
It repeats 2-5 times, and the extracting solution obtained every time is merged and is filtered, form the first extracting solution；Second raw material is added in into water and impregnates 1-2
Hour, it decocts and filters, form the second extracting solution；3rd raw material is decocted and filtered, alcohol is added to make its precipitation, filters to obtain supernatant
Liquid forms the 3rd extracting solution；
Distinct methods effective component extracting, the first raw material is respectively adopted in above-mentioned first raw material, the second raw material and the 3rd raw material
It is extracted using ethyl alcohol, this method can extract the lipophilic composition for being insoluble in water, and extraction time is short, and water-solubility impurity is few.Second is former
Material mainly obtains hydrophilic composition in Chinese herbal medicine using decocting cooking method.3rd extracting solution uses alcohol extracting after being decocted using first water
Method is obtaining the laggard onestep extraction lipophilicity of aqueous soluble active constituent, the active ingredient in raw material is made to play to the greatest extent
Out.
Step S03 mixes the first extracting solution with the second extracting solution, when heating 1-2 is small, when temperature is 60 DEG C near, then
3rd extracting solution is entered, postcooling obtains drug when continuation heating stirring 1 is small；
Step S04, the drug that step S03 is obtained are filtered by filter, under room temperature by filtrate with it is sterile, dry 20
Milliliter medicine bottle packing is finished product.
Application method：
Step S01 takes the method through femoral venous puncture, is manufactured on the secondary septum and septum primum of foramen ovale of heart patent
The fresh surface of a wound；
Step S02, it is postoperative 1 it is small when after take the drug, three times a day, a month as a treatment course.
Transesophageal echocardiography is determined as acleistocardia patient 36, takes the drug and passes through after 3 months esophagus
Echocardiography, the results show：29 recoveries from illness, 6 improvements, 1 without positive effect, cure rate is up to 81%.
Embodiment 2
A kind of drug for promoting acleistocardia border cell growth
Raw material object forms：(unit：g)
Radix Glycyrrhizae 10, twist with the fingers grass 100, Radix Notoginseng 50, cassia seed 80, lycopodium calvatum 120, windproof 100, Radix Astragali 20, Asian puccoon 150, ox
Knee 40, Rhizoma Chuanxiong 80, corydalis tuber 160, the radix paeoniae rubrathe 60, dipsacus root 20, Radix Salviae Miltiorrhizae 220, safflower 20, peach kernel 10, Western medicine 0.10.
It is prepared via a method which：
Step S01, by Radix Glycyrrhizae, twist with the fingers grass, Radix Notoginseng, cassia seed, lycopodium calvatum raw material and be mixed to form the first raw material；By it is windproof,
Radix Astragali, Asian puccoon, the root of bidentate achyranthes, Rhizoma Chuanxiong, corydalis tuber raw material are mixed to form the second raw material；By the radix paeoniae rubrathe, dipsacus root, Radix Salviae Miltiorrhizae, safflower, peach kernel raw material
It is mixed to form the 3rd raw material；
In above-mentioned first raw material, Radix Glycyrrhizae and Radix Notoginseng have effects that Huoxue San " blood, and adding for grass, cassia seed and lycopodium calvatum is twisted with the fingers on ground
Entering so that Huoxue San " blood effect of Radix Glycyrrhizae and Radix Notoginseng is more notable so that border cell grows faster, in addition, lycopodium calvatum
Windproof cold extermination and dehumidification swelling act on so that the fresh surface of a wound faster heals；
In above-mentioned second raw material, Asian puccoon, the root of bidentate achyranthes, Rhizoma Chuanxiong and corydalis tuber have effects that promoting blood circulation, promote breath and open depression, windproof
Addition with Radix Astragali is beneficial to the more preferable performance of Asian puccoon, the root of bidentate achyranthes, Rhizoma Chuanxiong and corydalis tuber promoting blood circulation, promote breath and open depression effect, into one
Step promotes the growth of oval foramen border cell, and wound is made faster to heal, and has the function that oval foramen is closed.It is in addition, windproof and yellow
Stilbene has effects that QI invigorating wind-dispelling, is conducive to the recovery of the constitution after patient trauma.
In above-mentioned 3rd raw material, dipsacus root, Radix Salviae Miltiorrhizae, safflower and peach kernel have effects that adjust blood vessels, cool blood dissipates the stasis of blood, and the radix paeoniae rubrathe adds
Enter can guarantee that dipsacus root, Radix Salviae Miltiorrhizae, safflower and peach kernel tune blood vessels, stablizing for cool blood dissipates the stasis of blood effect play, promote oval foramen border cell
Faster grow.In addition, the radix paeoniae rubrathe has effects that the row stasis of blood, detumescence and analgesic, the healing of patient wound position can be accelerated, it is real as early as possible
The closure of existing acleistocardia.
First raw material is added in vacuum extraction tank, adds the 5-8 times of ethyl alcohol measured by step S02, when refluxing extraction 1-2 is small,
It repeats 2-5 times, and the extracting solution obtained every time is merged and is filtered, form the first extracting solution；Second raw material is added in into water and impregnates 1-2
Hour, it decocts and filters, form the second extracting solution；3rd raw material is decocted and filtered, alcohol is added to make its precipitation, filters to obtain supernatant
Liquid forms the 3rd extracting solution；
Distinct methods effective component extracting, the first raw material is respectively adopted in above-mentioned first raw material, the second raw material and the 3rd raw material
It is extracted using ethyl alcohol, this method can extract the lipophilic composition for being insoluble in water, and extraction time is short, and water-solubility impurity is few.Second is former
Material mainly obtains hydrophilic composition in Chinese herbal medicine using decocting cooking method.3rd extracting solution uses alcohol extracting after being decocted using first water
Method is obtaining the laggard onestep extraction lipophilicity of aqueous soluble active constituent, the active ingredient in raw material is made to play to the greatest extent
Out.
Step S03 mixes the first extracting solution with the second extracting solution, when heating 1-2 is small, when temperature is 60 DEG C near, then
3rd extracting solution is entered, when continuation heating stirring 1 is small, treats that temperature is cooled to 40 DEG C；
Step S04, first plus clopidogrel, heating stirring are raised to 80 DEG C up to temperature, add aspirin, treat that temperature is cold
But to 40 DEG C, add vitamin C, continue stirring and be cooled to 15 DEG C.
Clopidogrel and aspirin can inhibit platelet aggregation, the incidence for reducing ischemic event, in traditional Chinese medicine ingredients
Clopidogrel and aspirin are added in, while oval foramen border cell growth is promoted, ensures the normal operation of heart, avoids
The generation of the angiocardiopathies such as thrombus makes closing course more safe and effective, and ascorbic addition can ensure clopidogrel and Ah
The performance of department woods effect, improves patient's immunity, promotes to recover faster.
Step S05, the drug that step S03 is obtained are filtered by filter, under room temperature by filtrate with it is sterile, dry 20
Milliliter medicine bottle packing is finished product.
Application method：
Step S01 takes the method through femoral venous puncture, is manufactured on the secondary septum and septum primum of foramen ovale of heart patent
The fresh surface of a wound；
Step S02, it is postoperative 1 it is small when after take the drug, three times a day, a month as a treatment course.
Transesophageal echocardiography is determined as acleistocardia patient 42, takes the drug and passes through after 3 months esophagus
Echocardiography, the results show：39 recoveries from illness, 3 improvements, cure rate is up to 93%.
Embodiment 3
A kind of drug for promoting acleistocardia border cell growth
Raw material object forms：(unit：g)
Radix Glycyrrhizae 30, twist with the fingers grass 80, Radix Notoginseng 80, cassia seed 60, lycopodium calvatum 90, windproof 130, Radix Astragali 30, Asian puccoon 170, the root of bidentate achyranthes
70th, Rhizoma Chuanxiong 50, corydalis tuber 150, the radix paeoniae rubrathe 100, dipsacus root 40, Radix Salviae Miltiorrhizae 200, safflower 40, peach kernel 30, Western medicine 0.10.
It is prepared via a method which：
Step S01, by Radix Glycyrrhizae, twist with the fingers grass, Radix Notoginseng, cassia seed, lycopodium calvatum raw material and be mixed to form the first raw material；By it is windproof,
Radix Astragali, Asian puccoon, the root of bidentate achyranthes, Rhizoma Chuanxiong, corydalis tuber raw material are mixed to form the second raw material；By the radix paeoniae rubrathe, dipsacus root, Radix Salviae Miltiorrhizae, safflower, peach kernel raw material
It is mixed to form the 3rd raw material；
In above-mentioned first raw material, Radix Glycyrrhizae and Radix Notoginseng have effects that Huoxue San " blood, and adding for grass, cassia seed and lycopodium calvatum is twisted with the fingers on ground
Entering so that Huoxue San " blood effect of Radix Glycyrrhizae and Radix Notoginseng is more notable so that border cell grows faster, in addition, lycopodium calvatum
Windproof cold extermination and dehumidification swelling act on so that the fresh surface of a wound faster heals；
In above-mentioned second raw material, Asian puccoon, the root of bidentate achyranthes, Rhizoma Chuanxiong and corydalis tuber have effects that promoting blood circulation, promote breath and open depression, windproof
Addition with Radix Astragali is beneficial to the more preferable performance of Asian puccoon, the root of bidentate achyranthes, Rhizoma Chuanxiong and corydalis tuber promoting blood circulation, promote breath and open depression effect, into one
Step promotes the growth of oval foramen border cell, and wound is made faster to heal, and has the function that oval foramen is closed.It is in addition, windproof and yellow
Stilbene has effects that QI invigorating wind-dispelling, is conducive to the recovery of the constitution after patient trauma.
In above-mentioned 3rd raw material, dipsacus root, Radix Salviae Miltiorrhizae, safflower and peach kernel have effects that adjust blood vessels, cool blood dissipates the stasis of blood, and the radix paeoniae rubrathe adds
Enter can guarantee that dipsacus root, Radix Salviae Miltiorrhizae, safflower and peach kernel tune blood vessels, stablizing for cool blood dissipates the stasis of blood effect play, promote oval foramen border cell
Faster grow.In addition, the radix paeoniae rubrathe has effects that the row stasis of blood, detumescence and analgesic, the healing of patient wound position can be accelerated, it is real as early as possible
The closure of existing acleistocardia.
First raw material is added in vacuum extraction tank, adds the 5-8 times of ethyl alcohol measured by step S02, when refluxing extraction 1-2 is small,
It repeats 2-5 times, and the extracting solution obtained every time is merged and is filtered, form the first extracting solution；Second raw material is added in into water and impregnates 1-2
Hour, it decocts and filters, form the second extracting solution；3rd raw material is decocted and filtered, alcohol is added to make its precipitation, filters to obtain supernatant
Liquid forms the 3rd extracting solution；
Distinct methods effective component extracting, the first raw material is respectively adopted in above-mentioned first raw material, the second raw material and the 3rd raw material
It is extracted using ethyl alcohol, this method can extract the lipophilic composition for being insoluble in water, and extraction time is short, and water-solubility impurity is few.Second is former
Material mainly obtains hydrophilic composition in Chinese herbal medicine using decocting cooking method.3rd extracting solution uses alcohol extracting after being decocted using first water
Method is obtaining the laggard onestep extraction lipophilicity of aqueous soluble active constituent, the active ingredient in raw material is made to play to the greatest extent
Out.
Step S03 mixes the first extracting solution with the second extracting solution, when heating 1-2 is small, when temperature is 60 DEG C near, then
3rd extracting solution is entered, when continuation heating stirring 1 is small, treats that temperature is cooled to 40 DEG C；
Step S04, first plus clopidogrel, heating stirring are raised to 80 DEG C up to temperature, add aspirin, treat that temperature is cold
But to 40 DEG C, add vitamin C, continue stirring and be cooled to 15 DEG C.
Clopidogrel and aspirin can inhibit platelet aggregation, the incidence for reducing ischemic event, in traditional Chinese medicine ingredients
Clopidogrel and aspirin are added in, while oval foramen border cell growth is promoted, ensures the normal operation of heart, avoids
The generation of the angiocardiopathies such as thrombus makes closing course more safe and effective, and ascorbic addition can ensure clopidogrel and Ah
The performance of department woods effect, improves patient's immunity, promotes to recover faster.
Step S05, the drug that step S03 is obtained are filtered by filter, under room temperature by filtrate with it is sterile, dry 20
Milliliter medicine bottle packing is finished product.
Application method：
Step S01 takes the method through femoral venous puncture, is manufactured on the secondary septum and septum primum of foramen ovale of heart patent
The fresh surface of a wound；
Step S02, it is postoperative 1 it is small when after take the drug, three times a day, a month as a treatment course.
Transesophageal echocardiography is determined as acleistocardia patient 40, takes the drug and passes through after 3 months esophagus
Echocardiography, the results show：36 recoveries from illness, 4 improvements, cure rate is up to 90%.
Embodiment 4
A kind of drug for promoting acleistocardia border cell growth
Raw material object forms：(unit：g)
Radix Glycyrrhizae 150, twist with the fingers grass 400, Radix Notoginseng 400, cassia seed 300, lycopodium calvatum 450, windproof 650, Radix Astragali 150, Asian puccoon
750th, the root of bidentate achyranthes 350, Rhizoma Chuanxiong 250, corydalis tuber 750, the radix paeoniae rubrathe 500, dipsacus root 200, Radix Salviae Miltiorrhizae 1000, safflower 200, peach kernel 150, Western medicine
0.01。
It is prepared via a method which：
Step S01, by Radix Glycyrrhizae, twist with the fingers grass, Radix Notoginseng, cassia seed, lycopodium calvatum raw material and be mixed to form the first raw material；By it is windproof,
Radix Astragali, Asian puccoon, the root of bidentate achyranthes, Rhizoma Chuanxiong, corydalis tuber raw material are mixed to form the second raw material；By the radix paeoniae rubrathe, dipsacus root, Radix Salviae Miltiorrhizae, safflower, peach kernel raw material
It is mixed to form the 3rd raw material；
In above-mentioned first raw material, Radix Glycyrrhizae and Radix Notoginseng have effects that Huoxue San " blood, and adding for grass, cassia seed and lycopodium calvatum is twisted with the fingers on ground
Entering so that Huoxue San " blood effect of Radix Glycyrrhizae and Radix Notoginseng is more notable so that border cell grows faster, in addition, lycopodium calvatum
Windproof cold extermination and dehumidification swelling act on so that the fresh surface of a wound faster heals；
In above-mentioned second raw material, Asian puccoon, the root of bidentate achyranthes, Rhizoma Chuanxiong and corydalis tuber have effects that promoting blood circulation, promote breath and open depression, windproof
Addition with Radix Astragali is beneficial to the more preferable performance of Asian puccoon, the root of bidentate achyranthes, Rhizoma Chuanxiong and corydalis tuber promoting blood circulation, promote breath and open depression effect, into one
Step promotes the growth of oval foramen border cell, and wound is made faster to heal, and has the function that oval foramen is closed.It is in addition, windproof and yellow
Stilbene has effects that QI invigorating wind-dispelling, is conducive to the recovery of the constitution after patient trauma.
In above-mentioned 3rd raw material, dipsacus root, Radix Salviae Miltiorrhizae, safflower and peach kernel have effects that adjust blood vessels, cool blood dissipates the stasis of blood, and the radix paeoniae rubrathe adds
Enter can guarantee that dipsacus root, Radix Salviae Miltiorrhizae, safflower and peach kernel tune blood vessels, stablizing for cool blood dissipates the stasis of blood effect play, promote oval foramen border cell
Faster grow.In addition, the radix paeoniae rubrathe has effects that the row stasis of blood, detumescence and analgesic, the healing of patient wound position can be accelerated, it is real as early as possible
The closure of existing acleistocardia.
First raw material is added in vacuum extraction tank, adds the 5-8 times of ethyl alcohol measured by step S02, when refluxing extraction 1-2 is small,
It repeats 2-5 times, and the extracting solution obtained every time is merged and is filtered, form the first extracting solution；Second raw material is added in into water and impregnates 1-2
Hour, it decocts and filters, form the second extracting solution；3rd raw material is decocted and filtered, alcohol is added to make its precipitation, filters to obtain supernatant
Liquid forms the 3rd extracting solution；
Distinct methods effective component extracting, the first raw material is respectively adopted in above-mentioned first raw material, the second raw material and the 3rd raw material
It is extracted using ethyl alcohol, this method can extract the lipophilic composition for being insoluble in water, and extraction time is short, and water-solubility impurity is few.Second is former
Material mainly obtains hydrophilic composition in Chinese herbal medicine using decocting cooking method.3rd extracting solution uses alcohol extracting after being decocted using first water
Method is obtaining the laggard onestep extraction lipophilicity of aqueous soluble active constituent, the active ingredient in raw material is made to play to the greatest extent
Out.
Step S03 mixes the first extracting solution with the second extracting solution, when heating 1-2 is small, when temperature is 60 DEG C near, then
3rd extracting solution is entered, when continuation heating stirring 1 is small, treats that temperature is cooled to 40 DEG C；
Step S04, first plus aspirin, heating stirring are raised to 80 DEG C up to temperature, add clopidogrel, treat that temperature is cold
But to 40 DEG C, add vitamin C, continue stirring and be cooled to 15 DEG C.
Clopidogrel and aspirin can inhibit platelet aggregation, the incidence for reducing ischemic event, in traditional Chinese medicine ingredients
Clopidogrel and aspirin are added in, while oval foramen border cell growth is promoted, ensures the normal operation of heart, avoids
The generation of the angiocardiopathies such as thrombus makes closing course more safe and effective, and ascorbic addition can ensure clopidogrel and Ah
The performance of department woods effect, improves patient's immunity, promotes to recover faster.
Step S05, the drug that step S03 is obtained are filtered by filter, under room temperature by filtrate with it is sterile, dry 20
Milliliter medicine bottle packing is finished product.
Application method：
Step S01 takes the method through femoral venous puncture, is manufactured on the secondary septum and septum primum of foramen ovale of heart patent
The fresh surface of a wound；
Step S02, it is postoperative 1 it is small when after take the drug, three times a day, a month as a treatment course.
Transesophageal echocardiography is determined as acleistocardia patient 45, takes the drug and passes through after 3 months esophagus
Echocardiography, the results show：43 recoveries from illness, 2 improvements, cure rate is up to 96%.
Embodiment 5
A kind of drug for promoting acleistocardia border cell growth
Raw material object forms：(unit：g)
Radix Glycyrrhizae 40, twist with the fingers grass 60, Radix Notoginseng 80, cassia seed 40, lycopodium calvatum 60, windproof 100, Radix Astragali 60, Asian puccoon 180, the root of bidentate achyranthes
100th, Rhizoma Chuanxiong 60, corydalis tuber 120, the radix paeoniae rubrathe 140, dipsacus root 60, Radix Salviae Miltiorrhizae 180, safflower 40, peach kernel 40, Western medicine 0.10.
It is prepared via a method which：
Step S01, by Radix Glycyrrhizae, twist with the fingers grass, Radix Notoginseng, cassia seed, lycopodium calvatum raw material and be mixed to form the first raw material；By it is windproof,
Radix Astragali, Asian puccoon, the root of bidentate achyranthes, Rhizoma Chuanxiong, corydalis tuber raw material are mixed to form the second raw material；By the radix paeoniae rubrathe, dipsacus root, Radix Salviae Miltiorrhizae, safflower, peach kernel raw material
It is mixed to form the 3rd raw material；
In above-mentioned first raw material, Radix Glycyrrhizae and Radix Notoginseng have effects that Huoxue San " blood, and adding for grass, cassia seed and lycopodium calvatum is twisted with the fingers on ground
Entering so that Huoxue San " blood effect of Radix Glycyrrhizae and Radix Notoginseng is more notable so that border cell grows faster, in addition, lycopodium calvatum
Windproof cold extermination and dehumidification swelling act on so that the fresh surface of a wound faster heals；
In above-mentioned second raw material, Asian puccoon, the root of bidentate achyranthes, Rhizoma Chuanxiong and corydalis tuber have effects that promoting blood circulation, promote breath and open depression, windproof
Addition with Radix Astragali is beneficial to the more preferable performance of Asian puccoon, the root of bidentate achyranthes, Rhizoma Chuanxiong and corydalis tuber promoting blood circulation, promote breath and open depression effect, into one
Step promotes the growth of oval foramen border cell, and wound is made faster to heal, and has the function that oval foramen is closed.It is in addition, windproof and yellow
Stilbene has effects that QI invigorating wind-dispelling, is conducive to the recovery of the constitution after patient trauma.
In above-mentioned 3rd raw material, dipsacus root, Radix Salviae Miltiorrhizae, safflower and peach kernel have effects that adjust blood vessels, cool blood dissipates the stasis of blood, and the radix paeoniae rubrathe adds
Enter can guarantee that dipsacus root, Radix Salviae Miltiorrhizae, safflower and peach kernel tune blood vessels, stablizing for cool blood dissipates the stasis of blood effect play, promote oval foramen border cell
Faster grow.In addition, the radix paeoniae rubrathe has effects that the row stasis of blood, detumescence and analgesic, the healing of patient wound position can be accelerated, it is real as early as possible
The closure of existing acleistocardia.
First raw material is added in vacuum extraction tank, adds the 5-8 times of ethyl alcohol measured by step S02, when refluxing extraction 1-2 is small,
It repeats 2-5 times, and the extracting solution obtained every time is merged and is filtered, form the first extracting solution；Second raw material is added in into water and impregnates 1-2
Hour, it decocts and filters, form the second extracting solution；3rd raw material is decocted and filtered, alcohol is added to make its precipitation, filters to obtain supernatant
Liquid forms the 3rd extracting solution；
Distinct methods effective component extracting, the first raw material is respectively adopted in above-mentioned first raw material, the second raw material and the 3rd raw material
It is extracted using ethyl alcohol, this method can extract the lipophilic composition for being insoluble in water, and extraction time is short, and water-solubility impurity is few.Second is former
Material mainly obtains hydrophilic composition in Chinese herbal medicine using decocting cooking method.3rd extracting solution uses alcohol extracting after being decocted using first water
Method is obtaining the laggard onestep extraction lipophilicity of aqueous soluble active constituent, the active ingredient in raw material is made to play to the greatest extent
Out.
Step S03 mixes the first extracting solution with the second extracting solution, when heating 1-2 is small, when temperature is 60 DEG C near, then
3rd extracting solution is entered, when continuation heating stirring 1 is small, treats that temperature is cooled to 40 DEG C；
Clopidogrel, vitamin C, aspirin are added in mixed liquor, when heating stirring 1 is small, are cooled to by step S04
15℃。
Clopidogrel and aspirin can inhibit platelet aggregation, the incidence for reducing ischemic event, in traditional Chinese medicine ingredients
Clopidogrel and aspirin are added in, while oval foramen border cell growth is promoted, ensures the normal operation of heart, avoids
The generation of the angiocardiopathies such as thrombus makes closing course more safe and effective, and ascorbic addition can ensure clopidogrel and Ah
The performance of department woods effect, improves patient's immunity, promotes to recover faster.
Step S05, the drug that step S03 is obtained are filtered by filter, under room temperature by filtrate with it is sterile, dry 20
Milliliter medicine bottle packing is finished product.
Application method：
Step S01 takes the method through femoral venous puncture, is manufactured on the secondary septum and septum primum of foramen ovale of heart patent
The fresh surface of a wound；
Step S02, it is postoperative 1 it is small when after take the drug, three times a day, a month as a treatment course.
Transesophageal echocardiography is determined as acleistocardia patient 39, takes the drug and passes through after 3 months esophagus
Echocardiography, the results show：35 recoveries from illness, 4 improvements, cure rate is up to 90%.
Experimental example 1
The animal acute toxicity test of drug of the present invention
The present embodiment has investigated the drug of the preparation of embodiment 2 by the measure of Mouse oral administration medicine median lethal dose
To the acute toxic reaction and death condition of mouse.
Take mouse 30, every group 10, points 3 groups, i.e. high, medium and low 3 dosage groups (1.0,0.6,0.3ml/15g) gavage
The scope of Calculating Median Lethal Dose of Drugs is predicted in 3 times/day of administration.The results show that high dose group does not measure median lethal dose, therefore by medicine
The measure of object gastric infusion median lethal dose, which changes, does the measure that the maximum under maximum volume does point-maximal tolerance dose.
Take mouse 30, on an empty stomach 12 it is small when after, to predict selected 1.0ml/15g meterings by only gastric infusion to tested dynamic
3 times/day of object is observed continuously 7 days.
When gavage gives small by test product 24, mouse spontaneous activity declines, and ingests, takes the photograph water reduction；Second day spontaneous living
Moving gradually tends to be normal, stool, urine no abnormality seen, and mouse activity, food ration, body weight increase, excrement etc. are normal, and observation expires
Test mice is all survived afterwards.
Whole test mice gross necropsies are put to death in observation after expiring, each important organ is found, such as the heart, liver, spleen, lung, kidney, ovum
Nest, intestines, stomach etc. change without apparent pathomorphism.
The maximum dosage-feeding result of the test of drug gastric infusion shows：It is anti-without apparent toxicity after 30 mouse administrations
Should, also without death in one week.To maximal tolerance dose is measured after intragastric administration on mice administration medicine as 40.2g/kgd, such as by it is clinical into
Human oral dosage form 10g/60kg is calculated, then the mouse of medicine gavage maximal tolerance dose on the one is clinical oral dose on the one of being grown up
[(40.2g/kg) ÷ (10.0g/60kg) ≈ 240] times.Illustrate that the security of Chinese medicine composition of the present invention is good.
Experimental example 2
A kind of human trial for the drug that acleistocardia border cell is promoted to grow of the present invention
Clinical data
1st, general information
Transesophageal echocardiography is determined as acleistocardia patient.
2nd, therapy
The method through femoral venous puncture is taken, fresh wound is manufactured on the secondary septum and septum primum of heart patent foramen ovale
The drug of experimental example 2 of the present invention is taken in face, 1 bottle every time, 3 times a day.Low oil, bland diet, no smoking and drinking, medication 1 during medication
A month as a treatment course.It is rechecked after continuously taking three months to hospital.
3rd, standard is treated
(1) fully recover：Oval foramen is closed
(2) improve：Oval foramen is closed substantially
(3) it is invalid：Oval foramen still patent
4th, treatment results：(see the table below 1)
1 treatment results of table
It these are only the preferred embodiment of the present invention and experimental example, be not intended to limit the invention, for this field
Technical staff for, the invention may be variously modified and varied.Within the spirit and principles of the invention, that is made appoints
What modification, equivalent substitution, improvement etc., should all be included in the protection scope of the present invention.
Claims (9)
1. a kind of drug for promoting acleistocardia border cell growth, which is characterized in that be made of the raw material of following parts by weight：
1~4 part of Radix Glycyrrhizae, twist with the fingers grass 5~10 parts, 5~10 parts of Radix Notoginseng, 2~8 parts of cassia seed, 6~12 parts of lycopodium calvatum, it is 10~15 parts windproof,
1~6 part of Radix Astragali, 15~20 parts of Asian puccoon, 4~10 parts of the root of bidentate achyranthes, 2~8 parts of Rhizoma Chuanxiong, 12~18 parts of corydalis tuber, 6~14 parts of the radix paeoniae rubrathe, river
0.01~0.1 part of 2~6 parts disconnected, 18~22 parts of Radix Salviae Miltiorrhizae, 2~6 parts of safflower, 1~4 part of peach kernel and Western medicine.
2. drug according to claim 1, which is characterized in that be made of the raw material of following parts by weight：3 parts of Radix Glycyrrhizae, twist with the fingers
Grass 8 parts, 8 parts of Radix Notoginseng, 6 parts of cassia seed, 9 parts of lycopodium calvatum, 13 parts windproof, 3 parts of Radix Astragali, 17 parts of Asian puccoon, 7 parts of the root of bidentate achyranthes, 5 parts of Rhizoma Chuanxiong,
0.05 part of 15 parts of corydalis tuber, 10 parts of the radix paeoniae rubrathe, 4 parts of dipsacus root, 20 parts of Radix Salviae Miltiorrhizae, 4 parts of safflower, 3 parts of peach kernel and Western medicine.
3. drug according to claim 1, which is characterized in that be made of the raw material of following parts by weight：1 part of Radix Glycyrrhizae, twist with the fingers
10 parts of grass, 5 parts of Radix Notoginseng, 8 parts of cassia seed, 12 parts of lycopodium calvatum, 10 parts windproof, 2 parts of Radix Astragali, 15 parts of Asian puccoon, 4 parts of the root of bidentate achyranthes, Rhizoma Chuanxiong 8
Part, 16 parts of corydalis tuber, 6 parts of the radix paeoniae rubrathe, 2 parts of dipsacus root, 22 parts of Radix Salviae Miltiorrhizae, 2 parts of safflower, 1 part of peach kernel and 0.1 part of Western medicine.
4. drug according to claim 1, which is characterized in that be made of the raw material of following parts by weight：4 parts of Radix Glycyrrhizae, twist with the fingers
Grass 6 parts, 8 parts of Radix Notoginseng, 4 parts of cassia seed, 6 parts of lycopodium calvatum, 10 parts windproof, 6 parts of Radix Astragali, 18 parts of Asian puccoon, 10 parts of the root of bidentate achyranthes, 6 parts of Rhizoma Chuanxiong,
0.01 part of 12 parts of corydalis tuber, 14 parts of the radix paeoniae rubrathe, 6 parts of dipsacus root, 18 parts of Radix Salviae Miltiorrhizae, 4 parts of safflower, 4 parts of peach kernel and Western medicine.
5. drug according to claim 1, which is characterized in that the Western medicine is made of the raw material of following parts by weight：Chlorine pyrrole
0.01~0.08 part of 0.01~0.05 part of Gray, 0.01~0.08 part of vitamin C and aspirin.
6. the preparation method of a kind of drug as any one of claim 1 to 5, which is characterized in that the medicine preparation walks
It is rapid as follows：
Step S01, by Radix Glycyrrhizae, twist with the fingers grass, Radix Notoginseng, cassia seed, lycopodium calvatum raw material and be mixed to form the first raw material；By windproof, Radix Astragali,
Asian puccoon, the root of bidentate achyranthes, Rhizoma Chuanxiong, corydalis tuber raw material are mixed to form the second raw material；The radix paeoniae rubrathe, dipsacus root, Radix Salviae Miltiorrhizae, safflower, peach kernel raw material are mixed
Form the 3rd raw material；
First raw material is added in vacuum extraction tank, adds the ethyl alcohol of 5~8 times of amounts by step S02, when refluxing extraction 1~2 is small, weight
It is 2~5 times multiple, and the extracting solution obtained every time is merged and is filtered, form the first extracting solution；Second raw material is added in into water and impregnates 1~2
Hour, it decocts and filters, form the second extracting solution；3rd raw material is decocted and filtered, alcohol is added to make its precipitation, filters to obtain supernatant
Liquid forms the 3rd extracting solution；
Step S03 mixes the first extracting solution with the second extracting solution, when heating 1~2 is small, when temperature is 60 DEG C near, then by the
Three extracting solutions add in, continue heating stirring 1 it is small when, treat temperature be cooled to 40 DEG C be separately added into clopidogrel, vitamin C part and Ah
Take charge of a woods.
7. preparation method according to claim 6, which is characterized in that the addition step of Western medicine is as follows：First plus clopidogrel,
Heating stirring is raised to 80 DEG C up to temperature, adds aspirin, treats that temperature is cooled to 40 DEG C, add vitamin C, continue to stir cold
But to 15 DEG C.
8. preparation method according to claim 6, which is characterized in that the addition step of Western medicine is as follows：First plus aspirin,
Heating stirring is raised to 80 DEG C up to temperature, adds clopidogrel, treats that temperature is cooled to 40 DEG C, add vitamin C, continue to stir cold
But to 15 DEG C.
9. preparation method according to claim 6, which is characterized in that the addition step of Western medicine is as follows：By clopidogrel, dimension
Raw element C, aspirin are added in mixed liquor, when heating stirring 1 is small, are cooled to 15 DEG C.
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Application publication date: 20180525 |