CN107468609B - A skin repairing composition for mosquito bite and water-based system containing the same - Google Patents
A skin repairing composition for mosquito bite and water-based system containing the same Download PDFInfo
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Abstract
The invention relates to the technical field of daily chemical products, in particular to a composition for relieving itching and repairing skin after being bitten by mosquitoes and a water-based system containing the composition. The menthol in the composition and the water-based system can provide cool feeling and can quickly relieve or dilute itching feeling, although the content of the menthol in the water-based system is lower than 2 percent, the menthol and other components are compounded in proper amount, and the coordination effect among the components can still ensure that the product has good itching relieving and swelling reducing effects. Although the invention is a water-based system without ethanol, the problem of menthol crystallization at low temperature (0-10 ℃) can not occur, so that the water-based system has wider selection of packing materials, for example, transparent packing materials can be selected, and consumers do not worry about the change of the product appearance.
Description
Technical Field
The invention relates to the technical field of daily chemical products, in particular to a composition for relieving itching and repairing skin after being bitten by mosquitoes and a water-based system containing the composition.
Background
Mosquitoes stab human skin through the mouth organ, saliva and secretion of the mosquitoes enter skin tissues, the skin can generate allergic reaction to exogenous components (antigens or sensitizing components) to cause inflammation, the appearance expression is pruritus and redness, and the skin expression of infants and children is more obvious. Some commercial antipruritic drugs can rapidly relieve itching and eliminate swelling, and the main ingredients are paralytic agents and anti-inflammatory agents, and known examples include antihistamines such as diphenhydramine hydrochloride and steroids (such as dexamethasone acetate, etc.), anesthetics such as procaine, tetracaine, dibucaine, lidocaine. Although these antipruritic drugs have a quick action, they are liable to cause dependence and also have side effects. Although some daily chemicals in commerce are declared to have the effects of relieving itching and reducing swelling, most of the daily chemicals have slow effect, poor itching relieving effect and undesirable red and swelling removing effect. Most of products with good effects use higher content of menthol, camphor or borneol, and the ethanol is matched as a solvent, the higher content of the substances inevitably causes stronger skin irritation, can temporarily solve the problems of pruritus and redness, but brings other problems of skin sensitivity or stabbing pain and the like. In addition, some products are prepared into an alcohol-free system by compounding menthol and the extract, and the common problems of the alcohol-free system products are that when the content of the menthol is higher, the system can separate out crystals at lower temperature (0-10 ℃), the appearance is influenced, and the use of packing materials is limited; if the content of menthol is reduced, the itching relieving and swelling diminishing effects are also reduced, and the formula selection is greatly limited.
The related technical field people hope to solve the skin problem after mosquito bite by compounding some compositions, and some medical technical people treat skin pruritus by compounding traditional Chinese medicines, such as patent publications CN201210258152.2, CN201510905942.9 and CN201610367963.4, wherein the traditional Chinese medicine components used in the patent publications are more than ten to more than ten, although the traditional Chinese medicines have good effect, the risks brought by unknown components of the traditional Chinese medicines are not ignored due to the use of too many traditional Chinese medicines, and the use of too many components shows that the compositions are only simple mixing, and the substances which particularly play a role in the compositions and the unknown how to fundamentally solve the source problem are unknown. The patent publication 201510643722.3 discloses a composition for relieving itching due to mosquito bite, which is prepared by compounding menthol with plant components, wherein the menthol content in the composition is 1-5%, and the menthol content is in a higher content range, and when the menthol content is higher than 2%, the damaged skin has stronger irritation, and due to the penetration-promoting property of the menthol, the camphor and ethanol compounded in the composition can increase the irritation of the whole composition, and the composition is not suitable for daily use of consumers. Patent publication 201210460995.0 discloses a preparation method of an artemisia argyi and honeysuckle flower extract, which is prepared by compounding artemisia argyi, honeysuckle flower, chrysanthemum flower and mint to achieve the efficacy of removing miliaria and relieving itching, but the extraction mode of the plant extracts still adopts the traditional decoction or steam distillation, and the active ingredients in the plant extracts belong to heat and oxygen sensitive ingredients, so that the active ingredients in the plant extracts are damaged to a great extent by using the extraction modes, and the menthol content obtained by using the steam distillation mode is low in the mixture, so that the itching relieving efficacy of the composition is worthy of being commensurable in process. Patent CN201210568326.5 discloses an antipruritic agent consisting of triclosan, sodium bicarbonate, ammonia, tea tree oil, menthol, but it has been shown that long term exposure to triclosan-containing products can affect the resistance or hormone levels of the human body, bringing health risks, and the FDA has issued a requirement that triclosan is banned from use in some daily chemical products.
Disclosure of Invention
The invention aims to solve the problems that the existing product used after being bitten by mosquitoes has large skin irritation or poor itching relieving and swelling diminishing effects or menthol crystals can be separated out from a product without an alcohol system in a low-temperature environment, and provides a composition which is used after being bitten by mosquitoes and has low menthol content and good itching relieving and swelling diminishing effects, and an alcohol-free water-based system which contains the composition and does not separate out the menthol crystals in the low-temperature environment.
In order to achieve the purpose, the invention adopts the following technical scheme.
A skin repairing composition for mosquito bites comprises the following components in parts by weight:
0.1-2 parts of menthol;
0.05-10 parts of honeysuckle extract;
0.05-18 parts of artemisia rupestris L extract;
0.1-10 parts of reed extract;
0.1-10 parts of poria cocos extract;
0.05-20 parts of licorice substance, wherein the licorice substance is at least one selected from glycyrrhizic acid, glycyrrhetate, glycyrrhetinic acid and glycyrrhetinate;
the honeysuckle extract, the artemisia rupestris L extract, the reed extract and the tuckahoe extract are all water-soluble extracts.
The skin repairing composition used after being bitten by mosquitoes preferably comprises the following components in parts by weight:
0.1-2 parts of menthol;
0.05-5 parts of honeysuckle extract;
0.05-10 parts of artemisia rupestris L extract;
1.5-4 parts of reed extract;
3-10 parts of poria cocos extract;
0.05-10 parts of liquorice substances.
Preferably, the menthol is natural menthol and/or levomenthol. The menthol can be used for quickly diluting or changing the itching feeling of the skin, the consistency of the cooling feeling can be ensured by controlling the mass percentage of the menthol in the water-based system to be lower than 2 percent, and if the addition amount of the menthol is too high, the cooling feeling can be converted into burning feeling or tingling feeling and cause skin irritation. Meanwhile, menthol can change the lipid conformation in the horny layer, so that the fluidity of the horny layer lipid bilayer is increased, the ordered compact structure is changed, the barrier effect of the skin is reduced, and the menthol can promote the skin to absorb active ingredients in the honeysuckle extract, the artemisia anomala extract, the reed extract and the poria cocos extract, and promote the exertion of the efficacy. Excessive use (above 2%) can exacerbate the degree of damage to the skin barrier and is detrimental to skin repair following mosquito bites.
Preferably, the honeysuckle extract is water-soluble powder obtained by carrying out low-temperature water extraction and spray drying on honeysuckle; more preferably, the extraction rate of the honeysuckle extract is 20-10: 1. The honeysuckle extract powder obtained by the process contains high-content chlorogenic acid, luteolin, galuteolin, rutin, inositol, macromolecular polysaccharide substances and the like, can effectively inhibit itch mediums released by keratinocytes, and can effectively promote skin barrier repair. The histamine released by the body after the human skin is bitten by mosquitoes can increase the permeability of the blood vessel wall, tissue fluid seeps out, the skin surface can show itching and red swelling, the skin barrier function is weakened, the ecological environment of the skin surface can also change, the honeysuckle extract can effectively inhibit staphylococcus aureus, escherichia coli, pseudomonas aeruginosa and streptococcus pyogenes, and the inflammation expansion caused by pathogenic bacteria can be effectively prevented.
Preferably, the artemisia rupestris L extract is water-soluble filtrate obtained by microwave extraction of artemisia rupestris L with glycerol, water and butanediol as mixed solvents. The artemisia anomala obtained by the process contains high-content flavonoid substances such as rutin and the like, can reduce the permeability and brittleness of a blood vessel wall, recovers the elasticity of the blood vessel, effectively prevents tissue fluid from seeping after being bitten by mosquitoes, lightens the enlargement of a packet after being bitten by the mosquitoes, has a synergistic effect by being compounded with the honeysuckle extract, can effectively inhibit the growth of pathogenic bacteria on the skin at the position of the bites by the mosquitoes and effectively inhibits the enlargement of the packet and the red swelling area by being compounded with the two.
Preferably, the reed extract is a water-soluble filtrate obtained by extracting reed with a buffered aqueous solvent at room temperature. The Poria extract is water soluble filtrate obtained by extracting Poria with buffered water solvent at room temperature. The extraction process can effectively preserve effective components such as coixol, D-glucose, D-galactose and the like in the reed extract, has a sedative effect on skin after being bitten by mosquitoes, reduces itching feeling, and can promote skin barrier repair. The extraction process can effectively preserve active ingredients such as pachyman, etc. in Poria extract, has effects of resisting oxidation, resisting inflammation, supporting barrier function, helping skin to overcome the defect of hypertonic stress, and promoting repair of affected part due to mosquito bite. The compound use of the reed extract and the tuckahoe extract can effectively inhibit pruritus, allergy and inflammation of histamine released by mast cells.
The liquorice substances contained in the composition have effective antioxidant, antiallergic and anti-inflammatory effects, can relieve excessive skin allergy after mosquito bites, has synergistic effect with the tuckahoe extract to inhibit the activity of tyrosinase, and effectively relieves pigmentation after mosquito bites.
The water-based system containing the skin repairing composition used after mosquito bites comprises the following components in percentage by mass:
1-50% of a skin-repairing composition for mosquito bites;
5-40% of 1, 3-butanediol;
0.2-10% of solubilizer;
0.1 to 7 percent of cosolvent;
the balance being water.
The water-based system containing the skin repairing composition used after being bitten by mosquitoes preferably comprises the following components in percentage by mass:
1-30.5% of a skin-repairing composition for mosquito bites;
10-20% of 1, 3-butanediol;
0.6-5% of solubilizer;
3-7% of cosolvent;
the balance being water.
Preferably, the water is deionized water.
Preferably, the solubilizer is selected from at least one of PEG-40 hydrogenated castor oil, PEG-60 hydrogenated castor oil, polysorbate-20, polysorbate-40, polysorbate-80, laureth-23, PPG-5 ceteth-20, oleyl ether-20, PEG-6 caprylic/capric glycerides, PEG-7 glyceryl cocoate, PEG-60 passion flower glycerides, PEG-45 palm oil glycerides, and PEG-60 amygdalin. The solubilizer has mild property, can directly contact with skin, has no stimulation to the skin, and does not influence the repair of the skin after biting.
Preferably, the cosolvent is a polar oleyl ester and/or a C12-18 alkanol polyether.
More preferably, the polar oil is at least one selected from isododecane, isohexadecane, octyldodecanol, C12-15 alcohol benzoate, diethylhexyl adipate, ethyl oleate, isopropyl isostearate, ethylhexyl nonanoate, diethylhexyl carbonate, polypropylene glycol-3-myristyl alcohol ether, decyl oleate and phenoxyethyloctanoic acid. The polar oil is a fluid liquid at the temperature of more than 0 ℃, has good dissolving capacity for menthol, can ensure the solubility of the menthol at the temperature of more than 0 ℃ under a proper proportion, and has mild property and no stimulation to skin.
More preferably, the C12-18 alkanol polyether is used as a non-ionic surfactant, the H L B value is 5-9.5, and the surfactant is at least one selected from the group consisting of laureth-2, laureth-3, laureth-4, C12-13 alkanol polyether-2, C12-13 alkanol polyether-3, C12-13 alkanol polyether-4, oleyl polyether-2, oleyl polyether-3, oleyl polyether-4 and oleyl polyether-5.
More preferably, the C12-18 alkanol polyether is a liquid that flows at ambient temperature.
The C12-18 alkanol polyether has better oleophylic property, surfactant property and excellent dissolving capacity, can be used for coordinating solubilization of a solubilizer by changing micelle forms and the dissolving state of menthol under different temperature conditions, ensures the transparency of a composition in a water-based system under proper proportion, and can ensure that a formula is clear and transparent at 0 ℃ under the alcohol-free condition.
The 1, 3-butanediol contained in the water-based system can not only keep the product state under the low-temperature condition, but also increase the micelle volume and improve the solubilization performance of the solubilizer by inserting the fence structure of the surfactant. 1, 3-butanediol has certain dissolving capacity to menthol and can help to improve the stability under low temperature conditions. The 1, 3-butanediol can be used as humectant to increase skin moisture and promote healing of affected parts.
The water-based system containing the skin repairing composition for mosquito bites can be added with other additives such as pH buffering agent, essence, preservative, xanthan gum, carbomer and the like according to the performance requirements of the product.
Compared with the prior art, the invention has the beneficial effects that:
the menthol in the composition and the water-based system can provide cool feeling and can quickly relieve or dilute itching feeling, although the content of the menthol in the water-based system is lower than 2 percent, the menthol and other components are compounded in proper amount, and the coordination effect among the components can still ensure that the product has good itching relieving and swelling reducing effects.
Because a series of skin reactions, namely pruritus, followed by wrapping and then redness and swelling, can be generated after the mosquito bites, the problem cannot be fundamentally solved by the combination of single functional components or functional similar components. The composition starts from the root of pruritus and redness, is in simplified design, and effectively solves the problems of pruritus, blocking, redness and swelling and the like in multi-dimensional anti-mosquito bite skin problems of cooling, calming, antibiosis, anti-inflammation, pruritus medium formation inhibition, allergy resistance, pigmentation inhibition, reduction of exudation of interstitial fluid, skin barrier repair and the like. In the invention, menthol extract provides cool feeling and promotes active ingredient penetration, honeysuckle extract and tuckahoe extract respectively inhibit itch against itch mediators released by keratinocytes and mast cells, the effect of artemisia sieversiana extract is mainly on eliminating bags, liquorice substances are mainly on inhibiting allergy, the reed extract is mainly on repairing skin barriers, the combination of the six components exerts a synergistic effect, and the absence of any one component can reduce the effect.
The extraction method adopted by the extract can furthest retain the stability of the active ingredients, and is favorable for ensuring the efficacy of the product.
The skin rejuvenation composition of the invention can be prepared into a transparent aqueous agent, namely the water-based system, by a conventional method, and can still maintain the transparent aqueous agent property under the condition of low temperature (higher than 0 ℃). The water-based system of the invention makes menthol get rid of the dependence on ethanol in the water-based system and solves the problem of low-temperature crystallization and precipitation of the menthol in the ethanol-free system. Although the invention is a water-based system without ethanol, the problem of menthol crystallization at low temperature (0-10 ℃) can not occur, so that the water-based system has wider selection of packing materials, for example, transparent packing materials can be selected, and consumers do not worry about the change of the product appearance.
Detailed Description
In order to more fully understand the technical contents of the present invention, the technical solutions of the present invention will be further described and illustrated with reference to the following specific embodiments.
The features, benefits and advantages of the present invention will become apparent to those skilled in the art from a reading of the present disclosure.
All percentages, parts and ratios are based on the total weight of the composition of the present invention, unless otherwise specified. All weights as they pertain to listed ingredients are assigned to levels of active material and, therefore, do not include solvents or by-products that may be included in commercially available materials, unless otherwise specified. The term "weight content" herein may be represented by the symbol "%".
The use of "including," "comprising," "containing," "having," or other variations thereof herein, is meant to encompass the non-exclusive inclusion, as such terms are not to be construed. The term "comprising" means that other steps and ingredients can be added that do not affect the end result. The term "comprising" also includes the terms "consisting of …" and "consisting essentially of …". The compositions and methods/processes of the present invention can comprise, consist of, and consist essentially of the essential elements and limitations described herein, as well as any of the additional or optional ingredients, components, steps, or limitations described herein.
The menthol used in the examples described below is natural menthol and/or levomenthol.
The honeysuckle extract, the artemisia rupestris extract, the reed extract and the poria cocos extract used in the following examples should meet the following requirements:
the flos Lonicerae extract is water soluble powder obtained by extracting flos Lonicerae with low temperature water (such as extraction temperature not higher than 25 deg.C) and spray drying; the extraction rate of the honeysuckle extract is 20-10:1 (the mass ratio of the honeysuckle raw material to the water-soluble powder obtained by extraction).
The Artemisia rupestris L extract is water-soluble filtrate obtained by microwave extraction of Artemisia rupestris L with glycerol, water and butanediol as mixed solvent.
The reed extract is a water-soluble filtrate obtained by extracting reed with a buffered aqueous solvent at room temperature.
The Poria extract is water soluble filtrate obtained by extracting Poria with buffered water solvent at room temperature.
Example 1
This example provides a skin rejuvenation composition for use after a mosquito bite, and an aqueous-based system containing the composition.
The skin repairing composition used after mosquito bites comprises the following components in parts by weight: 0.1 part of menthol, 0.15 part of honeysuckle extract, 0.3 part of artemisia anomala extract, 0.1 part of reed extract, 0.1 part of tuckahoe extract and 0.25 part of glycyrrhizic acid.
The water-based system containing the composition for repairing skin after being bitten by mosquitoes in the embodiment comprises the following components in parts by weight: 1 part of a skin repairing composition used after mosquito bites, 5 parts of 1, 3-butanediol, 3 parts of PEG-60 hydrogenated castor oil, 33 parts of C12-13 alkanol polyether, 0.1 part of pH buffering agent, 0.01 part of essence, 0.5 part of preservative and the balance of deionized water; the total amount of the water-based system formed was 100 parts.
Methods of preparing skin rejuvenation compositions for use after mosquito bites and water-based systems containing the skin rejuvenation compositions for use after mosquito bites described in this example: the raw materials are uniformly mixed according to a conventional method to obtain a clear and transparent solution.
Example 2
This example provides a skin rejuvenation composition for use after a mosquito bite, and an aqueous-based system containing the composition.
The skin repairing composition used after mosquito bites comprises the following components in parts by weight: 1 part of menthol, 2 parts of honeysuckle extract, 0.05 part of artemisia anomala extract, 1.5 parts of reed extract, 3 parts of tuckahoe extract and 0.05 part of glycyrrhetinic acid.
The water-based system containing the composition for repairing skin after being bitten by mosquitoes in the embodiment comprises the following components in parts by weight: 7.6 parts of a skin repairing composition used after being bitten by mosquitoes, 20 parts of 1, 3-butanediol, 1 part of diethylhexyl carbonate, 203 parts of PPG-5 cetyl polyether, 3 parts of PEG-60 hydrogenated castor oil, 43 parts of laureth, 0.05 part of pH buffering agent, 0.45 part of xanthan gum, 0.1 part of essence, 0.05 part of preservative and the balance of deionized water; the total amount of the water-based system formed was 100 parts.
Methods of preparing skin rejuvenation compositions for use after mosquito bites and water-based systems containing the skin rejuvenation compositions for use after mosquito bites described in this example: the raw materials are uniformly mixed according to a conventional method to obtain a clear and transparent solution.
Example 3
This example provides a skin rejuvenation composition for use after a mosquito bite, and an aqueous-based system containing the composition.
The skin repairing composition used after mosquito bites comprises the following components in parts by weight: 0.1 part of menthol, 3 parts of honeysuckle extract, 10 parts of artemisia anomala extract, 3 parts of reed extract, 3 parts of tuckahoe extract and 0.5 part of glycyrrhetinic acid.
The water-based system containing the composition for repairing skin after being bitten by mosquitoes in the embodiment comprises the following components in parts by weight: 19.6 parts of a skin repairing composition used after being bitten by mosquitoes, 10 parts of 1, 3-butanediol, 0.2 part of PEG-60 almond glycerides, 0.1 part of PEG-6 caprylic/capric glycerides, 20.2 parts of laureth, 0.08 part of pH buffering agent, 0.2 part of essence and the balance of deionized water; the total amount of the water-based system formed was 100 parts.
Methods of preparing skin rejuvenation compositions for use after mosquito bites and water-based systems containing the skin rejuvenation compositions for use after mosquito bites described in this example: the raw materials are uniformly mixed according to a conventional method to obtain a clear and transparent solution.
Example 4
This example provides a skin rejuvenation composition for use after a mosquito bite, and an aqueous-based system containing the composition.
The skin repairing composition used after mosquito bites comprises the following components in parts by weight: 2 parts of menthol, 5 parts of honeysuckle extract, 10 parts of artemisia anomala extract, 3 parts of reed extract, 10 parts of tuckahoe extract and 0.5 part of dipotassium glycyrrhizinate.
The water-based system containing the composition for repairing skin after being bitten by mosquitoes in the embodiment comprises the following components in parts by weight: 30.5 parts of a skin repairing composition used after mosquito bites, 20 parts of 1, 3-butanediol, 1 part of C12-15 alcohol benzoate, 1 part of PPG-5 cetyl polyether-201 parts, 3 parts of PEG-40 hydrogenated castor oil, 201 parts of polysorbate-201 parts, 36 parts of laureth-36 parts, 0.5 part of carbomer, 0.5 part of a neutralizing agent, 0.1 part of essence and the balance of deionized water; the total amount of the water-based system formed was 100 parts.
Methods of preparing skin rejuvenation compositions for use after mosquito bites and water-based systems containing the skin rejuvenation compositions for use after mosquito bites described in this example: the raw materials are uniformly mixed according to a conventional method to obtain a clear and transparent solution.
Example 5
This example provides a skin rejuvenation composition for use after a mosquito bite, and an aqueous-based system containing the composition.
The skin repairing composition used after mosquito bites comprises the following components in parts by weight: 0.1 part of menthol, 10 parts of honeysuckle extract, 0.05 part of artemisia anomala extract, 4 parts of reed extract, 6 parts of tuckahoe extract and 20 parts of dipotassium glycyrrhizinate.
The water-based system containing the composition for repairing skin after being bitten by mosquitoes in the embodiment comprises the following components in parts by weight: 40.15 parts of a skin repairing composition used after mosquito bites, 10 parts of 1, 3-butanediol, 1 part of C12-15 alcohol benzoate, 1 part of PPG-5 cetyl polyether-201 parts, 0.05 part of PEG-6 caprylic/capric glyceride, 0.15 part of PEG-60 almond glyceride, 40.1 parts of laureth-40, 0.2 part of pH buffering agent and the balance of deionized water; the total amount of the water-based system formed was 100 parts.
Methods of preparing skin rejuvenation compositions for use after mosquito bites and water-based systems containing the skin rejuvenation compositions for use after mosquito bites described in this example: the raw materials are uniformly mixed according to a conventional method to obtain a clear and transparent solution.
Example 6
This example provides a skin rejuvenation composition for use after a mosquito bite, and an aqueous-based system containing the composition.
The skin repairing composition used after mosquito bites comprises the following components in parts by weight: 2 parts of menthol, 0.05 part of honeysuckle extract, 0.1 part of artemisia anomala extract, 10 parts of reed extract, 0.2 part of tuckahoe extract and 1.0 part of glycyrrhetinic acid.
The water-based system containing the composition for repairing skin after being bitten by mosquitoes in the embodiment comprises the following components in parts by weight: 13.35 parts of a skin repairing composition used after mosquito bites, 40 parts of 1, 3-butanediol, 1 part of C12-15 alcohol benzoate, 32 parts of oleyl polyether, 202 parts of polysorbate, 8 parts of PEG-40 hydrogenated castor oil, 0.3 part of pH buffering agent and the balance of deionized water; the total amount of the water-based system formed was 100 parts.
Methods of preparing skin rejuvenation compositions for use after mosquito bites and water-based systems containing the skin rejuvenation compositions for use after mosquito bites described in this example: the raw materials are uniformly mixed according to a conventional method to obtain a clear and transparent solution.
Example 7
This example provides a skin rejuvenation composition for use after a mosquito bite, and an aqueous-based system containing the composition.
The skin repairing composition used after mosquito bites comprises the following components in parts by weight: 0.2 part of menthol, 1.8 parts of honeysuckle extract, 18 parts of artemisia anomala extract, 10 parts of reed extract, 10 parts of tuckahoe extract and 10 parts of dipotassium glycyrrhizinate.
The water-based system containing the composition for repairing skin after being bitten by mosquitoes in the embodiment comprises the following components in parts by weight: 50 parts of a skin repairing composition used after mosquito bites, 10 parts of 1, 3-butanediol, 200.2 parts of polysorbate, 0.4 part of PEG-40 hydrogenated castor oil, 30.3 parts of laureth, 0.4 part of pH buffering agent and the balance of deionized water; the total amount of the water-based system formed was 100 parts.
Methods of preparing skin rejuvenation compositions for use after mosquito bites and water-based systems containing the skin rejuvenation compositions for use after mosquito bites described in this example: the raw materials are uniformly mixed according to a conventional method to obtain a clear and transparent solution.
Comparative example 1
The itching relieving liquid sold in the market is alleged to relieve mosquito bites, and contains menthol without adding alcohol.
Comparative example 2
The antipruritic toilet water sold in the market is declared to rapidly relieve itching and contains menthol and alcohol.
Comparative example 3
This example provides a skin rejuvenation composition for use after a mosquito bite, and an aqueous-based system containing the composition.
The skin repairing composition used after mosquito bites comprises the following components in parts by weight: 0.5 part of menthol, 0.5 part of honeysuckle extract, 0.3 part of artemisia anomala extract, 1.5 parts of reed extract, 2 parts of tuckahoe extract and 0.5 part of dipotassium glycyrrhizinate.
The water-based system containing the composition for repairing skin after being bitten by mosquitoes in the embodiment comprises the following components in parts by weight: 5.3 parts of a skin repairing composition used after mosquito bites, 20 parts of 1, 3-butanediol, 1.2 parts of PEG-40 hydrogenated castor oil, 200.3 parts of polysorbate, 0.1 part of pH buffering agent, 0.01 part of essence, 0.5 part of preservative and the balance of deionized water; the total amount of the water-based system formed was 100 parts.
Methods of preparing skin rejuvenation compositions for use after mosquito bites and water-based systems containing the skin rejuvenation compositions for use after mosquito bites described in this example: the raw materials are uniformly mixed according to a conventional method to obtain a clear and transparent solution.
Comparative example 4
This example provides a skin rejuvenation composition for use after a mosquito bite, and an aqueous-based system containing the composition.
The skin repairing composition used after mosquito bites comprises the following components in parts by weight: 0.1 part of menthol, 0.15 part of honeysuckle extract, 0.1 part of reed extract, 0.1 part of tuckahoe extract and 0.25 part of glycyrrhizic acid.
The water-based system containing the composition for repairing skin after being bitten by mosquitoes in the embodiment comprises the following components in parts by weight: 0.7 part of skin repairing composition used after mosquito bites, 5 parts of 1, 3-butanediol, 3 parts of PEG-60 hydrogenated castor oil, 33 parts of C12-13 alkanol polyether, 0.1 part of pH buffering agent, 0.01 part of essence, 0.5 part of preservative and the balance of deionized water; the total amount of the water-based system formed was 100 parts.
Methods of preparing skin rejuvenation compositions for use after mosquito bites and water-based systems containing the skin rejuvenation compositions for use after mosquito bites described in this example: the raw materials are uniformly mixed according to a conventional method to obtain a clear and transparent solution.
Test for Low temperature resistance
The test samples 100m L of examples 1-7 and comparative examples 1-4 were respectively poured into a clear and clean plastic bottle, and placed in a 5 ℃ constant temperature refrigerator for 7 days, and the appearance change of the test samples was observed, and the test results are shown in Table 1, which proves that the present invention completely solves the problem of precipitation of menthol in an ethanol-free water-based system, from Table 1, it can be seen that a commercial formulation containing menthol of comparative example 1 precipitates crystals at a low temperature in the absence of ethanol, from comparative example 3 lacks a cosolvent component compared with examples 1-7, and from the result of Table 1, it can be seen that comparative example 3 precipitates crystals at a low temperature, comparative example 3 is only a simple example, and the cosolvent component disclosed in the present invention is indispensable for the application of the skin care composition for mosquito bites in a water-based ethanol-free system, and if the cosolvent disclosed in the present invention is not added, the prepared water-based system precipitates at a low temperature.
TABLE 1 test results of low temperature resistance
| Normal temperature sample appearance (25 ℃ C.) | Appearance of 5 ℃ sample | |
| Example 1 | Clear and transparent solution | Clear and transparent solution |
| Example 2 | Clear, transparent, viscous, flowable solutions | Clear, transparent, viscous, flowable solutions |
| Example 3 | Clear and transparent solution | Clear and transparent solution |
| Example 4 | Clear and transparent gel | Clear and transparent gel |
| Example 5 | Clear and transparent solution | Clear and transparent solution |
| Example 6 | Clear and transparent solution | Clear and transparent solution |
| Example 7 | Clear and transparent solution | Clear and transparent solution |
| Comparative example 1 | Clear and transparent solution | Crystal precipitation in the solution |
| Comparative example 2 | Clear and transparent solution | Clear and transparent solution |
| Comparative example 3 | Clear and transparent solution | Crystal precipitation in the solution |
| Comparative example 4 | Clear and transparent solution | Clear and transparent solution |
Test of antipruritic and bag-eliminating performance after mosquito bites
The test is carried out by taking the water-based system prepared in the example 1 as an example, and comparing the effect of the water-based system prepared in the comparative example 1, the comparative example 2 and the comparative example 4 after mosquito bites with a blank control (no measures are used after the bites).
Mosquito and tester screening process: firstly, qualified testers and test insects are screened according to an attack force test method in GB/T13917.9-2009, and the itching relieving test can be carried out only when the testers with qualified attack force are bitten by mosquitoes and have itching feeling, skin is wrapped and becomes red.
The itching relieving test process comprises the steps that 50 testers (half of men and women, the age of 20-45 years) are divided into 5 groups, 10 testers in each group are respectively a group of example 1, a group of comparative example 2, a group of comparative example 4 and a blank control group, the back of the hand of the tester is exposed out of a test area with the area of 4cm x 4cm, the rest parts are tightly shielded, the testers put the hand into a mosquito cage to bite 10s before mosquitoes, then the test samples 40 mu L are evenly smeared on the test area, the time of the skin itching process (itching relieving time) t1 and the time of the disappearance of the package blocks (package disappearing time) t2 are recorded.
And (3) test results: the experimental data of each group are subjected to statistical processing and tabulation description, the original data are expressed by mean plus minus standard deviation, and the significance of the difference between the blank control group and other groups is tested. The specific experimental results are shown in table 2. According to the results of the table itch stopping time t1, compared with a blank control group, the skin repairing composition for mosquito bites and the water-based system have significant differences (P < 0.01) in example 1, comparative example 2 and (P < 0.01) in example 1, comparative example 2, which shows that the skin repairing composition for mosquito bites and the water-based system for mosquito bites can relieve itch well on skin after mosquito bites and have better effect than the commercial products, and the extract of artemisia rupestris in example 1 and comparative example 4 have significant differences (P < 0.05) in example 1 and comparative example 4, which shows that the removal of the artemisia rupestris extract in the components can reduce the itch relieving effect. According to the results of the bale breaking time t2 in the table, compared with a blank control group, the skin repairing composition for the mosquito bites and the water-based system have significant differences (P < 0.05) in example 1, comparative example 1 and comparative example 2, and the results show that the skin repairing composition for the mosquito bites and the water-based system have good detumescence effect on the skin after the mosquito bites and are better than the products sold in the market, and the results show that the bale breaking effect is obviously reduced by removing the artemisia intermediate bittersweet extract in the components (P < 0.01) in example 1 and comparative example 4.
TABLE 2 test results of antipruritic and anti-mosquito bite bag performance
Toxicology test and human body safety test
In this test, the aqueous base systems of example 4 and example 7 are used as examples, and the formulations of the examples are tested for acute oral toxicity, acute transdermal toxicity, skin irritation, skin allergy, skin phototoxicity and human skin patch test according to the 2015 edition of cosmetic safety specifications, and the specific results are shown in table 3.
TABLE 3 toxicological test and human safety test results
| Type of test | Example 4 | Example 7 |
| Acute oral toxicity | Is practically non-toxic | Is practically non-toxic |
| Skin irritation | Has no irritation | Has no irritation |
| Cutaneous allergic reactions | No skin allergy | No skin allergy |
| Phototoxicity of skin | No phototoxicity | No phototoxicity |
| Patch test on human skin | Qualified | Qualified |
The technical contents of the present invention are further illustrated by the examples, so as to facilitate the understanding of the reader, but the embodiments of the present invention are not limited thereto, and any technical extension or re-creation based on the present invention is protected by the present invention.
Claims (7)
1. The skin repairing composition for mosquito bites is characterized by comprising the following components in parts by weight:
0.1-2 parts of menthol;
0.05-10 parts of honeysuckle extract;
0.05-18 parts of artemisia rupestris L extract;
0.1-10 parts of reed extract;
0.1-10 parts of poria cocos extract;
0.05-20 parts of licorice substance, wherein the licorice substance is at least one selected from glycyrrhizic acid, glycyrrhetate, glycyrrhetinic acid and glycyrrhetinate;
the honeysuckle extract, the artemisia rupestris L extract, the reed extract and the tuckahoe extract are all water-soluble extracts;
the menthol is natural menthol and/or levo menthol; the honeysuckle extract is water-soluble powder obtained by carrying out low-temperature water extraction and spray drying on honeysuckle; the artemisia rupestris L extract is water-soluble filtrate obtained by microwave extraction of artemisia rupestris L with glycerin, water and butanediol as mixed solvents; the reed extract is water-soluble filtrate obtained by extracting reed at normal temperature by using a buffered aqueous solvent; the Poria extract is water soluble filtrate obtained by extracting Poria with buffered water solvent at room temperature.
2. The composition for repairing skin after mosquito bite according to claim 1, which is characterized by comprising the following components in parts by weight:
0.1-2 parts of menthol;
0.05-5 parts of honeysuckle extract;
0.05-10 parts of artemisia rupestris L extract;
1.5-4 parts of reed extract;
3-10 parts of poria cocos extract;
0.05-10 parts of liquorice substances.
3. A water-based system of a skin repairing composition used after being bitten by mosquitoes is characterized by comprising the following components in percentage by mass:
1-50% of the skin rejuvenation composition for use after a mosquito bite of claim 1;
5-40% of 1, 3-butanediol;
0.2-10% of solubilizer;
0.1 to 7 percent of cosolvent;
the balance of water;
the solubilizer is at least one selected from PEG-40 hydrogenated castor oil, PEG-60 hydrogenated castor oil, polysorbate-20, polysorbate-40, polysorbate-80, laureth-23, PPG-5 ceteth-20, oleyl polyether-20, PEG-6 caprylic/capric glyceride, PEG-7 glyceryl cocoate, PEG-60 passionflower glyceride, PEG-45 palm oil glyceride and PEG-60 amygdalin;
the cosolvent is selected from polar grease and/or C12-18 alkanol polyether.
4. The water-based system according to claim 3, characterized by consisting of the following components in mass percent:
1-30.5% of the composition for skin repair after mosquito bites according to claim 1;
10-20% of 1, 3-butanediol;
0.6-5% of solubilizer;
3-7% of cosolvent;
the balance being water.
5. The water-based system according to claim 3, wherein the polar oil is at least one selected from isododecane, isohexadecane, octyldodecanol, C12-15 alcohol benzoate, diethylhexyl adipate, ethyl oleate, isopropyl isostearate, ethylhexyl nonanoate, diethylhexyl carbonate, polypropylene glycol-3 myristyl ether, decyl oleate, and phenoxyethyl octanoic acid.
6. The aqueous-based system of claim 3, wherein the C12-18 alkanol polyether has an H L B value of 5 to 9.5.
7. The aqueous system of claim 3, wherein the C12-18 alkanol polyether is selected from at least one of laureth-2, laureth-3, laureth-4, C12-13 alkanol polyether-2, C12-13 alkanol polyether-3, C12-13 alkanol polyether-4, oleyl polyether-2, oleyl polyether-3, oleyl polyether-4, oleyl polyether-5.
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| CN102727405A (en) * | 2011-04-15 | 2012-10-17 | 薛惠英 | Mosquito-expelling and antipruritic liquid |
| CN104940075A (en) * | 2015-06-29 | 2015-09-30 | 周建志 | Floral water for preventing mosquito bites |
| CN105534871A (en) * | 2016-02-17 | 2016-05-04 | 广西大学 | Mosquito-repelling and itching-relieving floral water and preparation method thereof |
| CN105663018A (en) * | 2014-12-03 | 2016-06-15 | 玫琳凯有限公司 | Cosmetic composition |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102727405A (en) * | 2011-04-15 | 2012-10-17 | 薛惠英 | Mosquito-expelling and antipruritic liquid |
| CN105663018A (en) * | 2014-12-03 | 2016-06-15 | 玫琳凯有限公司 | Cosmetic composition |
| CN104940075A (en) * | 2015-06-29 | 2015-09-30 | 周建志 | Floral water for preventing mosquito bites |
| CN105534871A (en) * | 2016-02-17 | 2016-05-04 | 广西大学 | Mosquito-repelling and itching-relieving floral water and preparation method thereof |
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