CN107456210A - Biaxial texture molecular imaging device - Google Patents
Biaxial texture molecular imaging device Download PDFInfo
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- CN107456210A CN107456210A CN201710597225.3A CN201710597225A CN107456210A CN 107456210 A CN107456210 A CN 107456210A CN 201710597225 A CN201710597225 A CN 201710597225A CN 107456210 A CN107456210 A CN 107456210A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
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Abstract
The invention provides a kind of biaxial texture molecular imaging device, including Optical Transmit Unit, the first reflector element, scanning element, relay unit, it is interior peep unit, the second reflector element and probe unit, wherein Optical Transmit Unit is used to launch light beam；First reflector element is used for the reflected beams；Scanning element is used to the light beam scanning of reflection arriving relay unit；Relay unit in the light beam after scanning is focused on for peeping unit；Unit is inside peeped to be used to conduct the light beam of focusing and focus on sample and receive the fluorescence that sample sends, relay unit and it is interior peep in unit, fluorescence is along the light path return different from light beam；Scanning element is additionally operable to fluorescent scanning to the second reflector element；Second reflector element is used for fluorescent reflection to probe unit；And probe unit is used to gather fluorescence.By two reflector elements, fluorescence can be made to be collected along with the light beam that Optical Transmit Unit is sent in the direction of smaller angle, so as to reduce the volume of whole device.
Description
Technical field
The present invention relates to medical instruments field, relates more specifically to a kind of biaxial texture molecular imaging device.
Background technology
Tumour is the major disease of serious threat human health.Nearly 30 years, global cancer (malignant tumour) morbidity number with
Average annual 3%~5% speed increase, cancer turn into one of most important cause of the death of the mankind.Clinical research at present finds that tumour is early
Phase not with transfer, easily excision, therefore, the early detection of tumour, early diagnosis be improve oncotherapy is horizontal, reduce treatment into
Originally the key of quality of life after, improving more.Numerous studies show more than 90% tumour derive from epithelial cell lesion, and
The variation of molecule and cellular level can occur during cancer occurrence and development.Relative to other medical imaging technologies (such as CT, MRI,
PET etc.), confocal scanning can reach micrometer resolution, and excellent with technologies such as lossless, real-time micrometer little tumour venereal disease changes
Gesture, it can preferably improve the early diagnostic rate of tumour.
The content of the invention
The present invention is proposed in view of above mentioned problem.The invention provides a kind of biaxial texture molecular imaging device, bag
Include Optical Transmit Unit, the first reflector element, scanning element, relay unit, it is interior peep unit, the second reflector element and probe unit,
Wherein described Optical Transmit Unit is used to launch light beam；First reflector element is used to reflect the light beam；The scanning element
For the light beam scanning of reflection to be arrived into the relay unit；The relay unit is used to focus on the light beam after scanning in described
Peep unit；Unit is peeped in described to be used to conduct the light beam of focusing and focus on sample and receive the fluorescence that sample is sent,
The relay unit and it is described it is interior peep in unit, the fluorescence returns along the light path different from light beam；The scanning element is also used
In by the fluorescent scanning to second reflector element；Second reflector element is used for the fluorescent reflection to the spy
Survey unit；And the probe unit is used to gather the fluorescence.
Exemplarily, the Optical Transmit Unit is used to launch Line beam, and the scanning element enters line scan, the detection
Unit is linear array probe unit.
Exemplarily, the Optical Transmit Unit includes：Light source, for launching collimated light beam；And line focus device is expanded, if
Put in the exit of the light source, be Line beam for the collimated light beam to be expanded into simultaneously one-dimensional focusing.
Exemplarily, the light incident direction of first reflector element and the light exit direction phase of second reflector element
Instead.
Exemplarily, the scanning element is galvanometer galvanometer or MEMS galvanometers.
Exemplarily, described device also includes the fluorescence being arranged between the probe unit and second reflector element
Focalizer, wherein the fluorescent foci device is used for the fluorescent foci of second reflector element reflection to the detector.
Exemplarily, the fluorescent foci device includes condenser lens, for focusing on the glimmering of the second reflector element reflection
Light.
Exemplarily, described device also includes the slit being arranged between the fluorescent foci device and the probe unit,
For only allowing the fluorescence of focussing plane to pass through.
Exemplarily, described device also includes the optical filtering being arranged between the fluorescent foci device and the probe unit
Device, for filtering out veiling glare.
Exemplarily, described device also includes bar-shaped housing, the Optical Transmit Unit, first reflector element, institute
It is equal to state scanning element, second reflector element, the relay unit, the interior part for peeping unit and the probe unit
It is arranged in the housing.
Exemplarily, the relay unit includes beam splitting lens and plus lens, wherein：The beam splitting lens is used to separate
Into the light beam and fluorescence of the relay unit；And the plus lens be used for focus on enter the relay unit light beam and
Fluorescence.
Exemplarily, the interior unit of peeping includes coupling object lens and imaging optical fiber bundle, wherein：The coupling object lens are arranged on
One end of the imaging light shafts, for the light beam coupling of the focusing to be entered to the near-end of the fibre bundle；And it is described into
As fibre bundle is used to conduct the light beam entered.
Exemplarily, peeping unit in described also includes miniature object lens, and the miniature object lens are arranged on the imaging light shafts
The other end, the light beam for the fibre bundle to be conducted focuses on the sample.
The biaxial texture molecular imaging device is excited using light beam to sample, and using probe unit to sample excitation
Optical detection is copolymerized Jiao to realize, aerial image is carried out to tissue element.Due to depositing for the first reflector element and the second reflector element
, fluorescent design can be detected unit collection into along with the light beam that Optical Transmit Unit is sent in the direction of smaller angle, from
And the volume of whole device can be reduced.
Brief description of the drawings
The embodiment of the present invention is described in more detail in conjunction with the accompanying drawings, above-mentioned and other purpose of the invention,
Feature and advantage will be apparent.Accompanying drawing is used for providing further understanding the embodiment of the present invention, and forms explanation
A part for book, it is used to explain the present invention together with the embodiment of the present invention, is not construed as limiting the invention.In the accompanying drawings,
Identical reference number typically represents same or similar part or step.
Fig. 1 shows the schematic block diagram of biaxial texture molecular imaging device according to an embodiment of the invention；And
Fig. 2 shows the light path schematic diagram of the biaxial texture molecular imaging device according to a specific embodiment of the invention.
Embodiment
Become apparent in order that obtaining the object, technical solutions and advantages of the present invention, root is described in detail below with reference to accompanying drawings
According to the example embodiment of the present invention.Obviously, described embodiment is only the part of the embodiment of the present invention, rather than this hair
Bright whole embodiments, it should be appreciated that the present invention is not limited by example embodiment described herein.Described in the present invention
The embodiment of the present invention, those skilled in the art's all other embodiment resulting in the case where not paying creative work
It should all fall under the scope of the present invention.
Fig. 1 and Fig. 2 schematically show biaxial texture molecular imaging device according to an embodiment of the invention
100 block diagram and index path.The biaxial texture molecular imaging device 100 include Optical Transmit Unit 110, the first reflector element 120,
Scanning element 130, relay unit 140, interior peep unit 150, the second reflector element 160 and probe unit 170.The biaxial texture point
Sub- imaging device 100 can be widely applied to alimentary canal,
The tissue element imaging at each position such as respiratory tract, realize the early diagnosis and lesion monitoring of tumour.
Optical Transmit Unit 110 can launch the light beam of such as collimation.Preferably, Optical Transmit Unit 110 can be used for launching
Line beam.In a specific embodiment, Optical Transmit Unit 110 can include light source 112 and expand line focus device 114.Light source
112 are used to launch collimated light beam.Light source 112 can be the laser of the collimation laser of transmitting specific wavelength.The specific wavelength
It may range from 20nm-2000nm.Laser in the wave-length coverage can excite large-scale fluorophor.Light source 112 can be
Quantum-well laser, solid-state laser, gas laser (such as argon ion laser) or laser diode.Expand line focus
Device 114 is arranged on the outlet of light source 112, and the collimated light beam for light source 112 to be sent expands and one-dimensional focusing is Line beam.Expand
Bunch focalizer 114 can include extender lens and post lens.Extender lens can include two L1, L2, two extender lenses
L1, L2, which coordinate, is expanded the collimated light beam that light source 112 is sent, to change the diameter of collimated light beam.Post lens can include
L3, its light beam one-dimensional focusing after expanding are Line beam and conducted to the first reflector element 120.
First reflector element 120 is located at the downstream of Optical Transmit Unit 110, for reflecting the line of the transmitting of Optical Transmit Unit 110
Light beam.In Fig. 1-2, solid line is used to represent the Line beam that Optical Transmit Unit 110 is sent, and dotted line is used to represent that sample is excited to send
Fluorescence.First reflector element 120 can be speculum.
Scanning element 130 receives the light beam of the first reflector element 120 reflection, and light beam scanning is arrived into relay unit 140.
When the light beam that Optical Transmit Unit 110 is launched is Line beam, scanning element 130 can enter line scan.Specifically, Line beam can
Think the Line beam for example extended in X direction, the Line beam is redirect to relay unit 140 by scanning element 130, while carries out Y
Scanning direction.Scanning element 130 carries out the one-dimensional sweeping of Y-direction to Line beam, and then coordinates progress one with the Line beam of X-direction
Scanning can in secondary Y-direction forms entire image.Y-direction is angled with X-direction, such as into 90 degree of right angle.This
When, probe unit 170 can be linear array probe unit.Thus, using Line beam combination linear array probe unit 170 can line by line into
Picture, therefore be greatly improved compared to existing point-by-point imaging, image taking speed.In addition, scanning element 130 can realize it is double
Instead, i.e., Line beam and fluorescence are all reflected, will also introduces reflection of the scanning element 130 to fluorescence hereinafter.Scanning element 130 can be with
The speculum either swung for galvanometer galvanometer or MEMS (MEMS) galvanometers based on other sports equipments.Scanning is single
The frequency of member 130 can be in 10-2000KHz frequency range.The situation of one-dimensional square scanning is only carried out in scanning element 130
Under, scanning element 130 can only include a galvanometer galvanometer or MEMS galvanometers.The use of single galvanometer can be greatly reduced
Noise, and the composition of compact device and the complexity of control, improve complete machine stability, while reduce manufacturing cost and dimension
Protect cost.In addition, scanning element 130 can also be spatial light modulator.Spatial light modulator compared to scanning galvanometer for, into
This is of a relatively high.
Relay unit 140 in the light beam after scanning is focused on for peeping unit 150.Unit 150 is inside peeped to be used for relaying
The Line beam that unit 140 focuses on conducts and focused on sample, and receives the fluorescence that sample is sent.The repeated unit of the fluorescence
140th, gathered after the reflector element 160 of scanning element 130 and second by probe unit 170.In relay unit 140 and interior peep unit
In 150, fluorescence returns along the light path different from light beam.
Relay unit 140 is usually lens group.In a specific embodiment, it is saturating can to include light splitting for relay unit 140
Mirror 142 and plus lens 144.Beam splitting lens 142 is used for the light beam and fluorescence for being segregated into relay unit 140, so that fluorescence edge
Unit 150 is peeped in the light path entrance different from light beam and returns to scanning element 130 along different light paths, to be detected unit
170 are received.Plus lens 144 is used for the light beam and fluorescence for focusing on this part.Plus lens 144 can be to include multiple lens
Lens group.Plus lens 144 has numerous embodiments, as long as its function can be realized.First, plus lens 144 will
Light beam is converged at the detection faces of sample 170.Detection faces can be located at the required depth below sample surfaces.Sample 170
Fluorogen at the detection faces is excited to send fluorescence.Fluorescence signal is collected by relay unit 140, and the edge road different from light beam
Footpath returns to scanning element 130.Relay unit 140 can have various implementations, as long as its function can be realized.Such as
Described in upper, scanning element 130 has double counter-functions to light beam and fluorescence.The scanned unit 130 of fluorescence scans anti-to second
Penetrate unit 160.Second reflector element 160 can be speculum.Second reflector element 160 is by fluorescent reflection to probe unit 170.
Probe unit 170 includes collection fluorescence, and forms the spatial image of tissue.
Inside peep unit 150 to be used to conduct the Line beam that relay unit 140 focuses on and focus on sample, and receive sample
The fluorescence that product are sent.By probe unit 170 after the repeated unit 140 of the fluorescence, the reflector element 160 of scanning element 130 and second
Collection.Coupling object lens 152, miniature object lens 156 can be included and be coupling in coupling object lens 152 and miniature thing by inside peeping unit 150
Imaging optical fiber bundle 154 between mirror 156.Relay unit 140 can include a beam splitting lens and multiple plus lens, their phases
Mutually coordinate the rear pupil that the Line beam after scanning is relayed to the interior coupling object lens 152 peeped in unit 150.Coupling object lens 152 are used for
Line beam is coupled into (such as focusing) into the near-end of imaging optical fiber bundle 154 (close to one end of operating personnel).Imaging optical fiber bundle
154 are used to conduct Line beam to the distal end of imaging optical fiber bundle 154 (one end away from operating personnel).Miniature object lens 156 are used for
By in the detection faces of the Laser Focusing that imaging optical fiber bundle 154 conducts to sample.Fluorogen at the detection faces of sample is stimulated
Go out fluorescence.Fluorescence signal is collected by miniature object lens 156, and imaged fibre bundle 154, coupling object lens 152 and relay unit 140 pass
Lead, scanning element 130 scans, and the second reflector element 160 is reflected into probe unit 170.Light included by imaging optical fiber bundle 154
The quantity of wire harness can be more than ten.Miniature object lens 156 are not essential.It is optional in the case of less demanding to definition
Ground, it is convenient to omit miniature object lens 156.Miniature object lens 156 can be designed to extend into alimentary canal, respiratory tract etc., with digestion
The surface of road, respiratory tract etc. is in contact.
The biaxial texture molecular imaging device 100 also includes fluorescent foci device 180, and it is arranged on probe unit 170 and
Between two reflector elements 160.Fluorescent foci device 180 can be by the photosurface of the fluorescent foci of collection to probe unit 170.
In one specific embodiment, fluorescent foci device 180 can include condenser lens, as shown in Figure 2.Condenser lens is used to send out in sample
The fluorescent foci gone out.Probe unit 170 is used to gather the fluorescence signal after focusing on.Fluorescence after focusing is in probe unit 170
It is photosensitive on photosurface.The image taking speed of probe unit 170 is in the range of tens frames to several ten million frames.Pass through scanning element 130
Scanning, all detected unit 170 of the fluorescence that all rows of sample are sent receives, and according to scanning trajectory alignment into X-Y scheme
Picture, and then can quickly realize observable tissue element image.When Optical Transmit Unit 110 is the reflector element of Line beam, visit
It can be linear array detector to survey unit 170, including various types of line-scan digital cameras, such as CCD (charge coupled cell) linear array phase
Machine or CMOS (complementary metal oxide semiconductor) line-scan digital camera etc..
Alternatively, the biaxial texture molecular imaging device 100 also includes being arranged on fluorescent foci device 180 and probe unit
Slit 190 between 170, slit 190 are used to only allow the fluorescence of focussing plane to pass through.The size of slit 190 can be tens
Nanometer is in the range of tens millimeters.The presence of slit 190 causes the veiling glare outside focussing plane to be blocked, and only focuses on flat
The fluorescence that sample sends is illuminated on face by light beam to be received.Alternatively, the biaxial texture molecular imaging device 100 also includes filtering
Device.Filter (not shown) is arranged between fluorescent foci device 180 and probe unit 170, for filtering out veiling glare.There is slit
In 190 embodiment, filter can be arranged between fluorescent foci device 180 and slit 190.
Put it briefly, the light beam that Optical Transmit Unit 110 is sent, reflected through the first reflector element 120, scanning element 130 is swept
Retouch, relay unit 140 is relayed, interior unit 150 of peeping is transmitted and focused on, and excites fluorescence in sample, fluorescence is along different from light beam
Peep that unit 150 transmits, relay unit 140 relays, scanning element 130 scans and changes through the second reflector element 160 in optical routing
Probe unit 170 is transferred to after light path and forms spatial image.Due to depositing for the first reflector element 120 and the second reflector element 160
, fluorescent design can be detected unit collection into along with the light beam that Optical Transmit Unit 110 is sent in the direction of smaller angle,
So as to reduce the volume of whole device.
Exemplarily, the data that probe unit collects can be sent to computer, are received by computer and are handled.This
Outside, the computer can also be launched scanning element (such as frequency of galvanometer etc.), the exposure of probe unit and gain and light
Transmission power of unit etc. is controlled.
Preferably, the light incident direction of the first reflector element 120 and the second reflector element 160 light exit direction on the contrary,
With this, the volume of the biaxial texture molecular imaging device 100 can be reduced.The biaxial texture molecular imaging device 100 can be made
It is made hand-held slender rod shaped, compact volume and convenience.
Then, the biaxial texture molecular imaging device 100 also includes bar-shaped housing.Above-mentioned all parts, including light
Transmitter unit 110, the first reflector element 120, scanning element 130, relay unit 140, it is interior peep unit 150 a part (such as
Coupling object lens 152), the second reflector element 160 and probe unit 170 be arranged in housing.Operating personnel can hold the rod
The biaxial texture molecular imaging device 100 of shape, it is very easy to use.
For the biaxial texture molecular imaging device 100 using line source in the case of sample is excited for, can be with
Line beam is scanned using one-dimensional scanning unit 130 (such as single galvanometer), and using probe unit 170 to sample excitation
Optical detection, realize that copolymerization is burnt in one-dimensional square.Due to being combined using Line beam with probe unit 170 to obtain tissue element
Spatial image, the image taking speed of tissue element can be greatly improved, real time imagery can be achieved.Because scanning element 130 is only carried out
One-dimensional scanning, therefore the stability of system can be effectively improved.
Although describe example embodiment by reference to accompanying drawing here, it should be understood that above-mentioned example embodiment is merely exemplary
, and be not intended to limit the scope of the invention to this.Those of ordinary skill in the art can carry out various changes wherein
And modification, it is made without departing from the scope of the present invention and spiritual.All such changes and modifications are intended to be included in appended claims
Within required the scope of the present invention.
In several embodiments provided herein, it should be understood that disclosed apparatus and method, it can be passed through
Its mode is realized.For example, apparatus embodiments described above are only schematical, for example, the division of the unit, only
Only a kind of division of logic function, there can be other dividing mode when actually realizing, such as multiple units or component can be tied
Another equipment is closed or is desirably integrated into, or some features can be ignored, or do not perform.
In the specification that this place provides, numerous specific details are set forth.It is to be appreciated, however, that the implementation of the present invention
Example can be put into practice in the case of these no details.In some instances, known method, structure is not been shown in detail
And technology, so as not to obscure the understanding of this description.
Similarly, it will be appreciated that in order to simplify the present invention and help to understand one or more of each inventive aspect,
To the present invention exemplary embodiment description in, each feature of the invention be grouped together into sometimes single embodiment, figure,
Or in descriptions thereof.However, the method for the invention should be construed to reflect following intention：It is i.e. claimed
Application claims features more more than the feature being expressly recited in each claim.More precisely, such as corresponding power
As sharp claim reflects, its inventive point is the spy that can use all features less than some disclosed single embodiment
Levy to solve corresponding technical problem.Therefore, it then follows thus claims of embodiment are expressly incorporated in this specific
Embodiment, wherein each claim is in itself as separate embodiments of the invention.
It will be understood to those skilled in the art that in addition to mutually exclusive between feature, any combinations pair can be used
All features and so disclosed any method disclosed in this specification (including adjoint claim, summary and accompanying drawing)
Or all processes or unit of equipment are combined.Unless expressly stated otherwise, this specification (including adjoint right will
Ask, make a summary and accompanying drawing) disclosed in each feature can be replaced by the alternative features for providing identical, equivalent or similar purpose.
In addition, it will be appreciated by those of skill in the art that although some embodiments described herein include other embodiments
In included some features rather than further feature, but the combination of the feature of different embodiments means in of the invention
Within the scope of and form different embodiments.For example, in detail in the claims, embodiment claimed it is one of any
Mode it can use in any combination.
It should be noted that the present invention will be described rather than limits the invention for above-described embodiment, and ability
Field technique personnel can design alternative embodiment without departing from the scope of the appended claims.In the claims,
Any reference symbol between bracket should not be configured to limitations on claims.Word "comprising" does not exclude the presence of not
Element or step listed in the claims.Word "a" or "an" before element does not exclude the presence of multiple such
Element.The present invention can be by means of including the hardware of some different elements and being come by means of properly programmed computer real
It is existing.In if the unit claim of equipment for drying is listed, several in these devices can be by same hardware branch
To embody.The use of word first, second, and third does not indicate that any order.These words can be explained and run after fame
Claim.
The foregoing is only a specific embodiment of the invention or the explanation to embodiment, protection of the invention
Scope is not limited thereto, any one skilled in the art the invention discloses technical scope in, can be easily
Expect change or replacement, should all be included within the scope of the present invention.Protection scope of the present invention should be with claim
Protection domain is defined.
Claims (13)
1. a kind of biaxial texture molecular imaging device, including Optical Transmit Unit, the first reflector element, scanning element, relay unit,
Unit, the second reflector element and probe unit are inside peeped, wherein
The Optical Transmit Unit is used to launch light beam；
First reflector element is used to reflect the light beam；
The scanning element is used to the light beam scanning of reflection arriving the relay unit；
The relay unit, which is used to focus on the light beam after scanning in described, peeps unit；
Peep unit in described to be used to conduct the light beam of focusing and focus on sample and receive the fluorescence that sample is sent, in institute
State relay unit and it is described it is interior peep in unit, the fluorescence returns along the light path different from light beam；
The scanning element is additionally operable to the fluorescent scanning to second reflector element；
Second reflector element is used for the fluorescent reflection to the probe unit；And
The probe unit is used to gather the fluorescence.
2. device as claimed in claim 1, wherein, the Optical Transmit Unit is used to launch Line beam, and the scanning element is entered
Line scan, the probe unit are linear array probe unit.
3. device as claimed in claim 2, wherein, the Optical Transmit Unit includes：
Light source, for launching collimated light beam；And
Line focus device is expanded, is arranged on the exit of the light source, is line for the collimated light beam to be expanded into simultaneously one-dimensional focusing
Light beam.
4. device as claimed in claim 1, wherein, the light incident direction of first reflector element and the described second reflection are single
The light exit direction of member is opposite.
5. device as claimed in claim 1, wherein, the scanning element is galvanometer galvanometer or MEMS galvanometers.
6. device as claimed in claim 1, wherein, described device also includes being arranged at the probe unit and described second anti-
The fluorescent foci device penetrated between unit, wherein
The fluorescent foci device is used for the fluorescent foci of second reflector element reflection to the detector.
7. device as claimed in claim 6, wherein, the fluorescent foci device includes condenser lens, for focusing on described second
The fluorescence of reflector element reflection.
8. device as claimed in claim 6, wherein, described device also includes being arranged at the fluorescent foci device and the detection
Slit between unit, for only allowing the fluorescence of focussing plane to pass through.
9. device as claimed in claim 6, wherein, described device also includes being arranged at the fluorescent foci device and the detection
Filter between unit, for filtering out veiling glare.
10. device as claimed in claim 1, wherein, described device also includes bar-shaped housing, the Optical Transmit Unit, institute
State the first reflector element, the scanning element, second reflector element, the relay unit, interior peep unit one
Divide and the probe unit is arranged in the housing.
11. device as claimed in claim 1, wherein, the relay unit includes beam splitting lens and plus lens, wherein：
The beam splitting lens is used for the light beam and fluorescence for being segregated into the relay unit；And
The plus lens is used to focus on the light beam and fluorescence for entering the relay unit.
12. device as claimed in claim 1, wherein, the interior unit of peeping includes coupling object lens and imaging optical fiber bundle, wherein：
The coupling object lens are arranged on one end of the imaging light shafts, for the light beam coupling of the focusing to be entered into the light
The near-end of fine beam；And
The imaging optical fiber bundle is used to conduct the light beam entered.
13. device as claimed in claim 12, wherein, it is described in peep unit and also include miniature object lens, the miniature object lens are set
The other end in the imaging light shafts is put, the light beam for the fibre bundle to be conducted focuses on the sample.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710597225.3A CN107456210B (en) | 2017-07-20 | 2017-07-20 | Biaxial tissue molecular imaging device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710597225.3A CN107456210B (en) | 2017-07-20 | 2017-07-20 | Biaxial tissue molecular imaging device |
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| JP2008275791A (en) * | 2007-04-26 | 2008-11-13 | Olympus Corp | Scanning confocal microscope |
| CN101449963A (en) * | 2008-12-29 | 2009-06-10 | 浙江大学 | Laser co-focusing micro-endoscope |
| CN105424601A (en) * | 2015-12-22 | 2016-03-23 | 佛山市南海区欧谱曼迪科技有限责任公司 | Handheld confocal skin microscopic method and handheld confocal skin microscopic device |
| CN208837913U (en) * | 2017-07-20 | 2019-05-10 | 苏州微景医学科技有限公司 | Biaxial texture molecular imaging device |
-
2017
- 2017-07-20 CN CN201710597225.3A patent/CN107456210B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008275791A (en) * | 2007-04-26 | 2008-11-13 | Olympus Corp | Scanning confocal microscope |
| CN101449963A (en) * | 2008-12-29 | 2009-06-10 | 浙江大学 | Laser co-focusing micro-endoscope |
| CN105424601A (en) * | 2015-12-22 | 2016-03-23 | 佛山市南海区欧谱曼迪科技有限责任公司 | Handheld confocal skin microscopic method and handheld confocal skin microscopic device |
| CN208837913U (en) * | 2017-07-20 | 2019-05-10 | 苏州微景医学科技有限公司 | Biaxial texture molecular imaging device |
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| CN107456210B (en) | 2023-05-12 |
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