CN205758513U - A kind of dermatosis multi-modality imaging detecting system - Google Patents
A kind of dermatosis multi-modality imaging detecting system Download PDFInfo
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- CN205758513U CN205758513U CN201620358287.XU CN201620358287U CN205758513U CN 205758513 U CN205758513 U CN 205758513U CN 201620358287 U CN201620358287 U CN 201620358287U CN 205758513 U CN205758513 U CN 205758513U
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- galvanometer
- dermatosis
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Abstract
nullThe dermatosis multi-modality imaging detecting system that this utility model provides，Use super continuous spectrums laser instrument，Different wave length is chosen for particular skin tissue，Obtain EO-1 hyperion high-resolution confocal imaging，In combination with the feature that photoacoustic technique imaging depth is big，By high light spectrum image-forming technology、Reflective conjugate focus imaging technique and photoacoustic imaging technology three carry out the system integration，Form multi-modal optical imaging system，Compensate for single modality deficiency in terms of skin diagnosis，Compared with single modal technique，Multi-modal technology provides more complete information，Improve the sensitivity of dermatosis diagnosis、Accuracy and specificity etc.，Realize EO-1 hyperion、High-resolution、At a high speed、The multi-modal optical molecular image of deep skin medical diagnosis on disease，Diagnosis and clinical research for dermatosis provide new technological means，Be conducive to the raising of dermatosis diagnostic level，Dermatosis can be instructed to perform the operation simultaneously，Objective evaluation is provided to dermatosis treating medicine treatment.
Description
Technical field
This utility model relates to optical image technology field, especially relates to a kind of dermatosis multi-modality imaging detection and is
System.
Background technology
The important tool that skin Computed tomography, also referred to as skin copolymerization are burnt, skin CT is dermatosis detection.
Currently mainly use focusing principle altogether, replace wide field light source lighting sample with laser point light source, use pin before the detectors simultaneously
Hole forms some detection, and lighting point is conjugated relative to focal plane of lens with sensing point.Point beyond focal plane will not be at sensing point
Imaging, so can effectively suppress the impact of veiling glare.By the sweep mechanism such as galvanometer or displacement platform, form spatially 3-D scanning
Imaging, by obtaining sample 3-D view to the three-dimensional reconstruction of image.
But, employing co-focusing imaging method has writes weak point: the optical maser wavelength 1) used is relatively fewer, due to skin
The multiformity of component, there is larger difference to the absorption reflection characteristic of different wave length light wave in various compositions, can cause using difference
Imaging effect during wavelength is different, and wavelength cannot realize optimal imaging effect to specific skin constituents at least；2) imaging is deep
Degree deficiency.Skin co-focusing imaging has certain imaging depth, but maximum still can only be applicable only to about 500 μm
Body observes epidermis and high dermis, and along with the increase of imaging depth, its spatial resolution significantly reduces, and which has limited and is focused into altogether
As the application in dermatosis diagnosis.
Photoacoustic imaging is a kind of Novel lossless medical imaging procedure developed rapidly in recent years, based on biological tissue's interior lights
Learn absorption difference, using the ultrasonic lossless bio-photon formation method as medium.It combines the high-contrast of pure optical imagery
The high-penetration depth characteristic of characteristic and pure ultra sonic imaging, replaces the photon inspection in optical imagery with ultrasonic detector detection photoacoustic waves
Survey, from principle, avoid the impact of optical scattering, it is provided that high-contrast and high-resolution tissue image, breach height
Resolution Optical imaging depth " soft limiting " (1mm), can realize the deep layer in vivo tissue imaging of 50mm.But, its imaging speed
Spending burnt slower than copolymerization, copolymerization Jiao is poor for resolution ratio.
Although, in terms of the inspection diagnosis of dermatosis, although occur in that various skin image technology means, but all exist
Respective shortcoming.Additionally, due to the multiformity of the complexity of skin texture, composition, single modality can provide
Information is relatively fewer, it is impossible to meet actual demand.
Therefore, high light spectrum image-forming technology, reflective conjugate focus imaging technique and photoacoustic imaging technology three are carried out system
Integrated innovation, forms multi-modal optical imaging system, makes up single modality deficiency in terms of skin diagnosis, has compeled
The eyebrows and eyelashes.
Utility model content
The purpose of this utility model is: provide a kind of dermatosis multi-modality imaging detecting system, this dermatosis multimode
High light spectrum image-forming technology, reflective conjugate focus imaging technique and photoacoustic imaging technology three are carried out system by state image-forming detecting system
Integrated, form multi-modal optical imaging system, make up single modality deficiency in terms of skin diagnosis.
The technical solution of the utility model is: a kind of dermatosis multi-modality imaging detecting system, including high light spectrum image-forming
Unit, reflective co-focusing imaging unit, optical image unit and control unit；
Described high light spectrum image-forming unit includes: super continuous spectrums laser instrument and acousto-optic tunable filter, described super continuous spectrums
Laser instrument sends broadband light wave and enters described acousto-optic tunable filter, the optional one of described acousto-optic tunable filter
Or several wavelength passes through；
Described reflective co-focusing imaging unit includes: the one 1/2 wave plate, PBS prism, XY galvanometer scanning galvanometer, in
Continue camera lens, resonance galvanometer, middle scanning lens, cylinder mirror, large-numerical aperture object lens, imaging and focusing camera lens, pin hole, photomultiplier tube and
First amplifier；
Described optical image unit includes: laser instrument, the 2nd 1/2 wave plate, changeable reflecting mirror, PBS prism, XY galvanometer
Scanning galvanometer, relaying camera lens, resonance galvanometer, middle scanning lens, cylinder mirror, small value aperture object lens, annular ultrasonic transducer and the
Two amplifiers；
The working method of described reflective co-focusing imaging unit is: the light beam warp of described acousto-optic tunable filter outgoing
Being changed into S after described one 1/2 wave plate to polarized light, described S examines through described XY after described PBS prismatic reflection to polarized light again
Flowmeter scanning galvanometer, relaying camera lens laggard enter described resonance galvanometer, through described resonance galvanometer row scan after light beam, successively through institute
Focus on skin tissue sample after stating scanning lens, cylinder mirror and large-numerical aperture object lens；Described skin tissue sample reflects
Or scattered signal enters described resonance galvanometer, described signal successively after described large-numerical aperture thing, cylinder mirror and middle scanning lens
After described resonance galvanometer row scans the most successively after described relaying camera lens, XY galvanometer scanning galvanometer, enter described PBS rib
Mirror, PBS prism described in the P light transmission in described signal and through described imaging and focusing lens focus at described pin hole, through upper
The light beam stating pin hole is received and converted to first signal of telecommunication by described photomultiplier tube, and described first signal of telecommunication is put through described first
Big device amplifies, described control unit collection image reconstruction obtain the Confocal Images of tissue；
The working method of described optical image unit is: the ps pulsed laser and ns pulsed laser light beam of described laser emitting is through described
Being changed into P after 2 1/2 wave plates to polarized light, described P switches into described PBS rib to polarized beam through described changeable reflecting mirror
Mirror, through described PBS prism transmission P to polarized beam by described XY galvanometer scanning galvanometer scan after the most successively in described
Focus on skin tissue sample after camera lens, resonance galvanometer, middle scanning lens, cylinder mirror, small value aperture object lens；Described skin
Tissue sample produces photoacoustic signal after absorbing light wave, and described photoacoustic signal is converted to the second telecommunications by described annular ultrasonic transducer
Number, described second signal of telecommunication generates the light of tissue after described second amplifier amplifies and gathered data by described control unit
Acoustic image.
Below technique scheme is explained further:
Described XY galvanometer scanning galvanometer includes X galvanometer and described Y galvanometer, in described reflective co-focusing imaging unit work
When making, described X galvanometer keeps static and described Y galvanometer to be scanned.
When described optical image unit works, described resonance galvanometer keeps static.
The pore diameter range of described large-numerical aperture object lens between 1.0-1.4, the aperture model of described small value aperture object lens
It is trapped among between 0.3-1.0.
Described control unit signal is connected to described super continuous spectrums laser instrument, acousto-optic tunable filter, XY galvanometer are swept
Retouch galvanometer, resonance galvanometer and laser instrument.
Also include that signal is connected to the display unit of described control unit.
The utility model has the advantages that:
The dermatosis multi-modality imaging detecting system that this utility model provides, uses super continuous spectrums laser instrument, for spy
Determine skin histology and choose different wave length, it is thus achieved that EO-1 hyperion high-resolution confocal imaging, in combination with photoacoustic technique imaging depth
Big feature, carries out the system integration by high light spectrum image-forming technology, reflective conjugate focus imaging technique and photoacoustic imaging technology three,
Form multi-modal optical imaging system, compensate for single modality deficiency in terms of skin diagnosis, with single modal technique
Comparing, multi-modal technology provides more complete information, improves sensitivity, accuracy and the specificity etc. of dermatosis diagnosis, real
Existing EO-1 hyperion, high-resolution, at a high speed, the multi-modal optical molecular image of deep skin medical diagnosis on disease, for dermatosis diagnosis and
Clinical research provides new technological means, the beneficially raising of dermatosis diagnostic level, dermatosis can be instructed to perform the operation simultaneously,
Objective evaluation is provided to dermatosis treating medicine treatment.
Accompanying drawing explanation
The dermatosis multi-modality imaging detecting system structural representation that Fig. 1 provides for this utility model embodiment.
Wherein: super continuous spectrums laser instrument 1 and acousto-optic tunable filter the 2, the 1st wave plate 3, PBS prism 4, XY examine stream
Meter scanning galvanometer 5, relaying camera lens 6, resonance galvanometer 7, middle scanning lens 8, cylinder mirror 9, large-numerical aperture object lens 10, skin histology sample
Product 11, imaging and focusing camera lens 12, pin hole 13, photomultiplier tube the 14, first amplifier 15, control unit 16, laser instrument 17, second
1/2 wave plate 18, changeable reflecting mirror 19, small value aperture object lens 20, annular ultrasonic transducer 21 and the second amplifier 22.
Detailed description of the invention
Refer to Fig. 1, for this utility model embodiment provide dermatosis multi-modality imaging detection system include EO-1 hyperion
Image-generating unit, reflective co-focusing imaging unit, optical image unit, control unit and display unit.
Wherein, described high light spectrum image-forming unit includes: super continuous spectrums laser instrument 1 and acousto-optic tunable filter 2, described super
Continuous spectrum laser instrument 1 sends broadband light wave and enters described acousto-optic tunable filter 2, described acousto-optic tunable filter 2
One or more wavelength optional pass through；
It is appreciated that super continuous spectrums laser instrument 1 and acousto-optic tunable filter 2 (Acousto-optic Turnable
Filter, AOTF) form a Rapid wavelength selection and switching subsystem, super continuous spectrums laser instrument 1 sends broadband light wave,
One or more wavelength are quickly selected to pass through in AOTF wave-length coverage wherein, so can be according to the skin position of concrete detection
Put or pathological changes becomes some special wavelength of component selections to carry out imaging, to realize the image enhaucament to particular skin composition.
Described reflective co-focusing imaging unit includes: the one 1/2 wave plate 3, PBS prism 4, XY galvanometer scanning galvanometer 5,
Relaying camera lens 6, resonance galvanometer 7, middle scanning lens 8, cylinder mirror 9, large-numerical aperture object lens 10, imaging and focusing camera lens 12, pin hole 13,
Photomultiplier tube 14 and the first amplifier 15；
The working method of described reflective co-focusing imaging unit is: the light beam of described acousto-optic tunable filter 2 outgoing
After described one 1/2 wave plate 3, be changed into S to polarized light, described S to polarized light after described PBS prism 4 reflects again through described
Described resonance galvanometer 7 is entered after XY galvanometer scanning galvanometer 5, relaying camera lens 6, the light beam after described resonance galvanometer 7 row scans,
Focus on skin tissue sample 11 after described middle scanning lens 8, cylinder mirror 9 and large-numerical aperture object lens 10 successively；Described skin
Skin tissue sample 11 reflects or scattered signal enters successively after described large-numerical aperture object lens 10, cylinder mirror 9 and middle scanning lens 8
Described resonance galvanometer 7, described signal is swept through described relaying camera lens 6, XY galvanometer after described resonance galvanometer 7 row scans the most successively
After retouching galvanometer 5, enter described PBS prism 4, PBS prism 4 described in the P light transmission in described signal through described imaging and focusing mirror
12 focus at described pin hole 13, and the light beam through described pin hole 13 is received and converted to first by described photomultiplier tube 14
The signal of telecommunication, described first signal of telecommunication amplifies through described first amplifier 15, described control unit 16 gathers and image reconstruction obtains
The Confocal Images that must organize；
It is appreciated that described large-numerical aperture object lens 10 can move in right amount along optical axis, often moves a position and can get one
Confocal Images in individual aspect, can obtain the 3-D view of skin histology through image reconstruction.
Preferably, XY galvanometer scanning galvanometer unit 5 includes X galvanometer and described Y galvanometer, and wherein, X scan rate of vibrating mirror is relatively
Hurry up, can play row scan action, Y scan rate of vibrating mirror is relatively slow, can play column scan effect, burnt in above-mentioned reflective copolymerization
Under imaging pattern, X galvanometer keeps static, Y vibration mirror scanning.
Described optical image unit includes: laser instrument the 17, the 2nd 1/2 wave plate 18, changeable reflecting mirror 19, PBS prism 4,
XY galvanometer scanning galvanometer 5, relaying camera lens 6, resonance galvanometer 7, middle scanning lens 8, cylinder mirror 9, small value aperture object lens 20, annular
Ultrasonic transducer 21 and the second amplifier 22；
The working method of described optical image unit is: the ps pulsed laser and ns pulsed laser light beam of described laser instrument 17 outgoing is through described
Being changed into P after 2nd 1/2 wave plate 18 to polarized light, described P switches into institute to polarized beam through described changeable reflecting mirror 19
State PBS prism 4, depend on again after polarized beam is scanned by described XY galvanometer scanning galvanometer 5 through the P of described PBS prism 4 transmission
Secondary through described relaying camera lens 6, resonance galvanometer 7, middle scanning lens 8, cylinder mirror 9, small value aperture object lens 20 after focus on skin group
On tissue samples；Described skin tissue sample produces photoacoustic signal after absorbing light wave, and described annular ultrasonic transducer 21 is by described light
Acoustical signal is converted to second signal of telecommunication, and described second signal of telecommunication amplifies and by described control unit through described second amplifier 22
The photoacoustic image of tissue is generated after 16 collection data.
Preferably, the galvanometer 7 that resonates during above-mentioned photoacoustic imaging keeps static, and only XY galvanometer scanning galvanometer 5 is swept
Retouch.
Preferably, the pore diameter range of described large-numerical aperture object lens between 1.0-1.4, described small value aperture object lens
Pore diameter range is between 0.3-1.0.
Described control unit 16 is gone back signal and is connected to described super continuous spectrums laser instrument 1, acousto-optic tunable filter 2, XY inspection
Flowmeter scanning galvanometer 5, resonance galvanometer 7 and laser instrument 17.Described control unit 16 is preferably electronic control box.
It is appreciated that control unit 16 can control super continuous spectrums laser instrument 1 and the switch of laser instrument 17, power, record
Synchronizing signal etc.；Acousto-optic tunable filter 2 can also be controlled and carry out wavelength selection, and the laser selected is carried out power tune
Joint；At the same time it can also be control XY galvanometer scanning galvanometer 5, resonance galvanometer 7, scan mode, scope, sample frequency etc. are set；And
By controlling collection the first amplifier 15 and the signal of telecommunication of the second amplifier 22 output, carry out image reconstruction and generate Confocal Images
And photoacoustic image, and output image on display unit 23.Preferably, described display unit 23 is display.
The dermatosis multi-modality imaging detecting system that this utility model provides, uses super continuous spectrums laser instrument, for spy
Determine skin histology and choose different wave length, it is thus achieved that EO-1 hyperion high-resolution confocal imaging, in combination with photoacoustic technique imaging depth
Big feature, carries out the system integration by high light spectrum image-forming technology, reflective conjugate focus imaging technique and photoacoustic imaging technology three,
Form multi-modal optical imaging system, compensate for single modality deficiency in terms of skin diagnosis, with single modal technique
Comparing, multi-modal technology provides more complete information, improves sensitivity, accuracy and the specificity etc. of dermatosis diagnosis, real
Existing EO-1 hyperion, high-resolution, at a high speed, the multi-modal optical molecular image of deep skin medical diagnosis on disease, for dermatosis diagnosis and
Clinical research provides new technological means, the beneficially raising of dermatosis diagnostic level, dermatosis can be instructed to perform the operation simultaneously,
Objective evaluation is provided to dermatosis treating medicine treatment.
Certain dermatosis multi-modality imaging detecting system of the present utility model also can have multiple conversion and remodeling, not
It is confined to the concrete structure of above-mentioned embodiment.In a word, protection domain of the present utility model should include that those are general for this area
Obviously convert for logical technical staff or substitute and remodeling.
Claims (6)
1. a dermatosis multi-modality imaging detecting system, it is characterised in that include high light spectrum image-forming unit, reflective copolymerization
Burnt image-generating unit, optical image unit and control unit；
Described high light spectrum image-forming unit includes: super continuous spectrums laser instrument and acousto-optic tunable filter, described super continuous spectrums laser
Device sends broadband light wave and enters described acousto-optic tunable filter, and described acousto-optic tunable filter may select a kind of or several
Plant wavelength to pass through；
Described reflective co-focusing imaging unit includes: the one 1/2 wave plate, PBS prism, XY galvanometer scanning galvanometer, relay lens
Head, resonance galvanometer, middle scanning lens, cylinder mirror, large-numerical aperture object lens, imaging and focusing camera lens, pin hole, photomultiplier tube and first
Amplifier；
Described optical image unit includes: laser instrument, the 2nd 1/2 wave plate, changeable reflecting mirror, PBS prism, XY galvanometer scan
Galvanometer, relaying camera lens, resonance galvanometer, middle scanning lens, cylinder mirror, small value aperture object lens, annular ultrasonic transducer and second are put
Big device；
The working method of described reflective co-focusing imaging unit is: the light beam of described acousto-optic tunable filter outgoing is through described
Be changed into S after one 1/2 wave plate to polarized light, described S to polarized light after described PBS prismatic reflection again through described XY galvanometer
Scanning galvanometer, relaying camera lens laggard enter described resonance galvanometer, through described resonance galvanometer row scan after light beam, successively in described
Focus on skin tissue sample after scanning lens, cylinder mirror and large-numerical aperture object lens；Described skin tissue sample reflection or scattered
Penetrate signal after described large-numerical aperture object lens, cylinder mirror and middle scanning lens, enter described resonance galvanometer, described signal warp successively
After the scanning of described resonance galvanometer row the most successively after described relaying camera lens, XY galvanometer scanning galvanometer, enter described PBS prism,
PBS prism described in P light transmission in described signal and through described imaging and focusing lens focus at described pin hole, through described pin
The light beam in hole is received and converted to first signal of telecommunication by described photomultiplier tube, and described first signal of telecommunication is through described first amplifier
Amplify, described control unit collection image reconstruction obtain the Confocal Images of tissue；
The working method of described optical image unit is: the ps pulsed laser and ns pulsed laser light beam of described laser emitting is through the described 2nd 1/
Being changed into P after 2 wave plates to polarized light, described P switches into described PBS prism to polarized beam through described changeable reflecting mirror,
Pass through after described XY galvanometer scanning galvanometer scans the most successively through described relaying to polarized beam through the P of described PBS prism transmission
Focus on skin tissue sample after camera lens, resonance galvanometer, middle scanning lens, cylinder mirror, small value aperture object lens；Described skin group
Tissue samples produces photoacoustic signal after absorbing light wave, and described photoacoustic signal is converted to the second telecommunications by described annular ultrasonic transducer
Number, described second signal of telecommunication generates the light of tissue after described second amplifier amplifies and gathered data by described control unit
Acoustic image.
Dermatosis multi-modality imaging detecting system the most according to claim 1, it is characterised in that described XY galvanometer is swept
Retouching galvanometer and include X galvanometer and Y galvanometer, when described reflective co-focusing imaging cell operation, described X galvanometer keeps static and institute
State Y galvanometer to be scanned.
Dermatosis multi-modality imaging detecting system the most according to claim 1, it is characterised in that at described optical imagery
During cell operation, described resonance galvanometer remains static.
Dermatosis multi-modality imaging detecting system the most according to claim 1, it is characterised in that described large-numerical aperture
The pore diameter range of object lens is between 1.0-1.4, and the pore diameter range of described small value aperture object lens is between 0.3-1.0.
Dermatosis multi-modality imaging detecting system the most according to claim 1, it is characterised in that described control unit is believed
Number it is connected to described super continuous spectrums laser instrument, acousto-optic tunable filter, XY galvanometer scanning galvanometer, resonance galvanometer and laser
Device.
Dermatosis multi-modality imaging detecting system the most according to claim 5, it is characterised in that also include that signal connects
Display unit in described control unit.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105877711A (en) * | 2016-04-26 | 2016-08-24 | 中国科学院苏州生物医学工程技术研究所 | Multimode imaging detection system for skin disease |
| CN107144551A (en) * | 2017-04-12 | 2017-09-08 | 上海戴泽光电科技有限公司 | The burnt super-resolution imaging system and method for copolymerization based on sCMOS |
| CN108375560A (en) * | 2017-10-25 | 2018-08-07 | 南京大学 | A kind of laser co-focusing-two-photon-goes up changing multi state fluoroscopic imaging systems and its application |
| CN110101367A (en) * | 2019-05-10 | 2019-08-09 | 南方医科大学南方医院 | Probe, laser aid and laser scanning imaging system |
| CN110179446A (en) * | 2019-04-17 | 2019-08-30 | 南京航空航天大学 | A kind of multi-modality imaging equipment for combining optoacoustic and laser speckle |
| CN112869768A (en) * | 2021-01-12 | 2021-06-01 | 哈尔滨工业大学（威海） | Multi-modality imaging-based body function multi-parameter quantification method and device |
-
2016
- 2016-04-26 CN CN201620358287.XU patent/CN205758513U/en not_active Expired - Fee Related
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105877711A (en) * | 2016-04-26 | 2016-08-24 | 中国科学院苏州生物医学工程技术研究所 | Multimode imaging detection system for skin disease |
| CN105877711B (en) * | 2016-04-26 | 2019-01-18 | 吉林亚泰中科医疗器械工程技术研究院股份有限公司 | A kind of skin disease multi-modality imaging detection system |
| CN107144551A (en) * | 2017-04-12 | 2017-09-08 | 上海戴泽光电科技有限公司 | The burnt super-resolution imaging system and method for copolymerization based on sCMOS |
| CN107144551B (en) * | 2017-04-12 | 2020-01-24 | 上海戴泽光电科技有限公司 | Confocal super-resolution imaging system and method based on sCMOS |
| CN108375560A (en) * | 2017-10-25 | 2018-08-07 | 南京大学 | A kind of laser co-focusing-two-photon-goes up changing multi state fluoroscopic imaging systems and its application |
| CN110179446A (en) * | 2019-04-17 | 2019-08-30 | 南京航空航天大学 | A kind of multi-modality imaging equipment for combining optoacoustic and laser speckle |
| CN110101367A (en) * | 2019-05-10 | 2019-08-09 | 南方医科大学南方医院 | Probe, laser aid and laser scanning imaging system |
| CN112869768A (en) * | 2021-01-12 | 2021-06-01 | 哈尔滨工业大学（威海） | Multi-modality imaging-based body function multi-parameter quantification method and device |
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