CN107441191A - It is a kind of to be used to treat ointment medicine of psoriasis and preparation method thereof - Google Patents

It is a kind of to be used to treat ointment medicine of psoriasis and preparation method thereof Download PDF

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Publication number
CN107441191A
CN107441191A CN201710663292.0A CN201710663292A CN107441191A CN 107441191 A CN107441191 A CN 107441191A CN 201710663292 A CN201710663292 A CN 201710663292A CN 107441191 A CN107441191 A CN 107441191A
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China
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medicine
psoriasis
treat
chinese
ointment
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罗娟
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Chengdu Feilong Water Treatment Technology Institute
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Chengdu Feilong Water Treatment Technology Institute
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/06Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/28Mercury; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/36Arsenic; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • A61K35/646Arachnids, e.g. spiders, scorpions, ticks or mites
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/30Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489Sophora, e.g. necklacepod or mamani
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/714Aconitum (monkshood)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Insects & Arthropods (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention belongs to field of traditional Chinese, it is therefore an objective to which a kind of ointment medicine for being used to treat psoriasis provided according to the understanding mechanism of Chinese traditional treatment psoriasis, each component and its mass parts ratio of the medicine are as follows:0.5~1.8g of realgar, 10~25g of Aconitum Szechenyianum Gay, 10~60g of alum, 30~120g of kuh-seng, 1~5g of cinnabar, 20~50g of scorpio, 1.6~3g of borneol, 50~100g of Asian puccoon;Medicine provided by the invention is a good Chinese prescription.

Description

It is a kind of to be used to treat ointment medicine of psoriasis and preparation method thereof
Technical field
The invention belongs to field of traditional Chinese, and in particular to a kind of ointment medicine for being used to treat psoriasis, particularly The field of the ointment medicine used for psoriatic and preparation method thereof.
Background technology
Shown according to document:Psoriasis, psoriasis are commonly called as psoriasis, are a kind of chronic inflammatory skins, and the course of disease is longer, has Easy tendency of recurrence, some cases almost cannot be cured all one's life.The disease is fallen ill based on person between twenty and fifty, health and spiritual shape to patient Condition has a great influence.Clinical manifestation is with erythema, and based on the scales of skin that peel off, whole body can fall ill, and with scalp, it is relatively conventional that four limbs stretch side, exists more Winter aggravates.
Clinical manifestation:
A. psoriasis vulgaris
For a most common type, more acute onsets.Typical performance is the erythema that boundary understands, shape size differs, and around has inflammation Property blush.Slightly infiltration thickens.Surface covers the multilayer silvery white scales of skin that peel off.The scales of skin that peel off be easy to scrape it is de-, it is light red shinny semi-transparent after scraping Bright film, scratch the visible small blutpunkte of film(Auspitz's sign).Skin lesion is apt to occur in head, sacrum portion and four limbs and stretches side.Suffer from part Person feels different degrees of itch.
B. psoriasis pustulosa
It is more rare, point general hair style and palm plantar type.Generalized pustular psoriasis are occur gregariousness superficial in erythema sterile Property warts, can partly be fused into purulence lake.Whole body can fall ill.Side is bent with four limbs and gauffer position is common, and mucous membrane of mouth can be simultaneously Involvement.Acute onset or be often accompanied by shivering with cold, generate heat when aggravating suddenly, arthralgia, general malaise and white blood cell count(WBC) increase Constitutional symptom.Is in periodical attack more, psoriasis vulgaris often occurs in the paracmasis.Palmoplantar pustulosis skin lesion is confined to Brothers, symmetrical to occur, general status is good, and the state of an illness is obstinate, recurrent exerbation
C. erythrodermic psoriasis
Also known as psoriatic exfoliative dermatitis, it is a kind of serious psoriasis.It is long-term a large amount of often because of the stronger medicine of external application excitant Using glucocorticoid, it is reduced caused by too fast or unexpected drug withdrawal.Show as whole skin and diffuse sexflush, swelling and furfur, companion There are the constitutional symptoms such as heating, chilly, discomfort, superficial lymph knot enlargement, white blood cell count(WBC) increases.
4. arthropathic psoriasis
Also known as psoriasis arthropathica.The joint damage of rheumatoid arthritis sample occurs simultaneously for psoriatic, can involve complete The big Minor articulus of body, but referred to end(Toe)Interphalangeal joints lesion most characteristic.Affected joints congestion and swelling pain, periarticular skin Also it is often red and swollen.Joint symptoms are often aggravated or mitigated simultaneously with skin symptom.Blood rheumatoid factor negative.
So, a kind of Chinese medicine composition for imitating treatment psoriasis how is just found, is that those skilled in the art urgently will Solve the problems, such as.
The content of the invention
With the continuous development of China's traditional Chinese medicine, in treatment psoriasis, people gradually appreciate Chinese traditional treatment The advantages of psoriasis, and good effect, the advantage such as quick, toxic side effect is small over the course for the treatment of, for existing western medical treatment silver Consider the present situation of disease to be worth doing, the purpose of the present invention is to be to provide a kind of ointment medicine for being used to treat psoriasis, to solve psoriasis The problem of patient gets well early.The medicine is using common Chinese medicine as raw material, by selecting rational medicine
Thing and mass parts ratio, can effectively treat above-mentioned psoriasis.
To reach the purpose of foregoing invention, the technical solution adopted in the present invention is:There is provided a kind of for treating psoriasis Ointment medicine and preparation method thereof, it is characterised in that each component and its mass parts of the medicine are than as follows:
0.5~1.8g of realgar, 10~25g of Aconitum Szechenyianum Gay, 10~60g of alum, 30~120g of kuh-seng, 1~5g of cinnabar, scorpio 20~ 50g, 1.6~3g of borneol, 50~100g of Asian puccoon.
It is a kind of be used for treat ointment medicine of psoriasis and preparation method thereof, it is characterised in that the medicine it is each Component and its mass parts are than as follows:
0.8~1.5g of realgar, 12~21g of Aconitum Szechenyianum Gay, 12~52g of alum, 38~105g of kuh-seng, 2~4g of cinnabar, scorpio 26~ 43g, 1.8~2.8g of borneol, 58~90g of Asian puccoon.
It is a kind of to be used to treat ointment medicine of psoriasis and preparation method thereof, it is characterised in that " preferred plan " Medicine each component and its mass parts than as follows:
Realgar 1.3g, Aconitum Szechenyianum Gay 18g, alum 48g, kuh-seng 95g, cinnabar 3g, scorpio 38g, borneol 2.5g, Asian puccoon 80g.
It is a kind of to be used to treat ointment medicine of psoriasis and preparation method thereof, it is characterised in that methods described is included such as Lower step is prepared:
A, after above-mentioned raw materials Chinese medicine being picked impurity, dust and dried, it is stand-by to be ground into superfine end according to mass parts ratio;
B, ground superfine myrrh thing is put into special-purpose stirring machine container and be stirred, it is to be mixed uniformly rear stand-by;
C, the superfine myrrh thing to stir is put into finished product mixer container, adds appropriate chlorhexidine acetate or egg yolk After oil, mix, produce ointment medicine, sealing.
It is a kind of to be used to treat ointment medicine of psoriasis and preparation method thereof, it is characterised in that the application method is: The ointment medicine prepared is put on the skin in the site of disease cleaned up, while massages absorption, 30 days are a course for the treatment of, treatment 2~5 The individual course for the treatment of, symptom gradually slow down or obtained temporary transient healing.
Each raw material Chinese medicine in prescription of the present invention has detailed note in Chinese Pharmacopoeia, Chinese dictionary and China's book on Chinese herbal medicine Carry.The present invention is raw material from most common of which Chinese medicine, gives full play to the pharmacological effect of each component:
Realgar, nature and flavor:It is pungent, warm, it is poisonous, there is the effect of removing toxic substances desinsection, removing dampness and eliminating phlegm, preventing malaria, for treating carbuncle swells furunculosis, snake The diseases such as insect bite, abdominal pain due to enterositosis, frightened epilepsy, malaria;
Aconitum Szechenyianum Gay, nature and flavor:It is bitter, pungent, warm, it is very toxic, there is the effect of wind-expelling pain-stopping, dissipate stasis of blood hemostasis, detumescence and drawing out poison, for treating Scrofula is controlled in rheumatic arthritis, pain in waist and lower extremities, traumatic injury, external application(Do not break), ulcerative carbuncle pyogenic infections;
Alum, nature and flavor:It is sour and astringent, cold, it is poisonous, have eliminating the phlegm eliminating dampness, removing toxic substances desinsection, antidiarrheal hemostasis the effect of, for treat apoplexy, Polyp, sore hemorrhoid in epilepsy, larynx numbness, mange wet sore, swollen ulcer drug, scald, aphthae, belepharitis ciliaris eye, Ting discharging ear, nose Pain, uterine bleeding, bleeding from five sense organs or subcutaneous tissue, bleeding due to trauma, the dysentery of chronic diarrhea nine, with lower pruritus vulvae, prolapse of the anus, metroptosis;
Kuh-seng, nature and flavor:It is bitter, cold in nature, there is the effect of heat-clearing and damp-drying drug, wind dispelling insecticide, for treating damp-heat dysentery, intestines wind just Blood, jaundice, difficult urination, oedema, band under, pruritus vulvae, mange, leprosy, pruitus, wet poison sore;
Cinnabar, nature and flavor:Nature and flavor are sweet, are slightly cold, poisonous, have clear away heart-fire it is relieving convulsion, calm the nerves removing toxic substances the effect of, for treat palpitation and being susceptible to fright, Insomnia and dreamful sleep, epilepsy are gone mad, child convulsion, blurring of vision, aphtha, larynx numbness, sore swollen toxin;
Scorpio, nature and flavor:It is acrid flavour, mild-natured, it is poisonous, have expelling wind and relieving convulsion, remove obstruction in channels to relieve pain, rose poison dissipating bind the effect of, it is small for treating Youngster's infantile convulsion, twitch spasm, middle air port crooked, hemiplegia, lockjaw, rheumatoid arthritis stubborn, migraine and general headache, toothache, deafness, carbuncle swells sore The diseases such as poison, scrofula subcutaneous nodule, snake sting, burnt, rubella, stubborn dermatitis;
Borneol, nature and flavor:It is pungent, bitter, be slightly cold, have inducing resuscitation of having one's ideas straightened out, clearing away heat to and alleviating pain the effect of, for treating pyreticosis coma, convulsion is fainted, in Wind phlegm is fainted, bstruction of the circulation of vital energy is fainted cruelly, middle evil is gone into a coma, hot eyes, aphtha, and abscess of throat, duct are suppurated;
Asian puccoon, nature and flavor:It is sweet, salty, cold, there is the effect of cool blood, promoting blood circulation, removing toxic substances promoting eruption, it is purple for treating blood-heat and toxin exuberance, macula The diseases such as black, measles without adequate eruption, sore, eczema, scald.
Medicine of the present invention is the principle based on Chinese traditional treatment psoriasis, from the pathomechanism according to psoriasis and pharmacological action Think:With regard to psoriasis, each raw material herbal medicine efficacy in medicine provided by the present invention is played altogether, has good treatment to above-mentioned disease Effect.
Embodiment
A kind of Chinese medicine preparation that the present invention proposes aiming at the treatment of above-mentioned psoriasis, the medicine prepared using the formula Thing good drug efficacy, it is quick, it is a Chinese prescription treated both principal and secondary aspect of disease, is particularly suitable for Clinical practice.With reference to the tool of the present invention Body embodiment is described in further detail:
Embodiment 1:
A kind of ointment medicine for being used to treat psoriasis, it is characterised in that each component and its mass parts ratio of the medicine It is as follows:
Realgar 1.3g, Aconitum Szechenyianum Gay 18g, alum 48g, kuh-seng 95g, cinnabar 3g, scorpio 38g, borneol 2.5g, Asian puccoon 80g.
Embodiment 2:
A kind of ointment medicine for being used to treat psoriasis, it is characterised in that each component and its mass parts ratio of the medicine It is as follows:
Realgar 1.5g, Aconitum Szechenyianum Gay 21g, alum 52g, kuh-seng 105g, cinnabar 4g, scorpio 43g, borneol 2.8g, Asian puccoon 90g.
Embodiment 3:
A kind of ointment medicine for being used to treat psoriasis, it is characterised in that each component and its mass parts ratio of the medicine It is as follows:
Realgar 1.8g, Aconitum Szechenyianum Gay 25g, alum 60g, kuh-seng 120g, cinnabar 5g, scorpio 50g, borneol 3g, Asian puccoon 100g.
Model case
Through clinical conditions psoriatic totally 1960, the age is 1060 of more than 39 years old, only 900 for 39 years old with Under.Symptom gradually slows down or obtained temporarily cure 1271, effective 415, invalid 274 in 1960 patients.Always have Efficiency is up to 86%.

Claims (3)

1. a kind of ointment medicine for being used to treat psoriasis, it is characterised in that each component and its mass parts of the medicine Than as follows:
0.5~1.8g of realgar, 10~25g of Aconitum Szechenyianum Gay, 10~60g of alum, 30~120g of kuh-seng, 1~5g of cinnabar, scorpio 20~ 50g, 1.6~3g of borneol, 50~100g of Asian puccoon.
2. according to claim 1 be used to treat the ointment medicine of psoriasis, it is characterised in that the medicine it is each Component and its mass parts are than as follows:
0.8~1.5g of realgar, 12~21g of Aconitum Szechenyianum Gay, 12~52g of alum, 38~105g of kuh-seng, 2~4g of cinnabar, scorpio 26~ 43g, 1.8~2.8g of borneol, 58~90g of Asian puccoon.
3. the ointment medicine for being used to treat psoriasis according to claim 1 to 2, it is characterised in that the medicine Each component and its mass parts are than as follows:
Realgar 1.3g, Aconitum Szechenyianum Gay 18g, alum 48g, kuh-seng 95g, cinnabar 3g, scorpio 38g, borneol 2.5g, Asian puccoon 80g.
CN201710663292.0A 2017-08-05 2017-08-05 It is a kind of to be used to treat ointment medicine of psoriasis and preparation method thereof Withdrawn CN107441191A (en)

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CN201710663292.0A CN107441191A (en) 2017-08-05 2017-08-05 It is a kind of to be used to treat ointment medicine of psoriasis and preparation method thereof

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Application publication date: 20171208