CN107982476A - It is a kind of to be used to treat pill medicine of cervical carcinoma and preparation method thereof - Google Patents

It is a kind of to be used to treat pill medicine of cervical carcinoma and preparation method thereof Download PDF

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Publication number
CN107982476A
CN107982476A CN201711102343.9A CN201711102343A CN107982476A CN 107982476 A CN107982476 A CN 107982476A CN 201711102343 A CN201711102343 A CN 201711102343A CN 107982476 A CN107982476 A CN 107982476A
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medicine
cervical carcinoma
dandelion
treat
mass parts
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罗倩茹
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Sichuan Juhao Biotechnology Co Ltd
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Sichuan Juhao Biotechnology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/19—Acanthaceae (Acanthus family)
    • A61K36/195—Strobilanthes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233—Bupleurum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288—Taraxacum (dandelion)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A61K36/315—Isatis, e.g. Dyer's woad
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A61K36/748—Oldenlandia or Hedyotis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/884—Alismataceae (Water-plantain family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
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Abstract

The invention belongs to field of traditional Chinese, it is therefore an objective to a kind of pill medicine for being used to treat cervical carcinoma be provided according to the understanding mechanism of Chinese traditional treatment cervical carcinoma, each component and its mass parts ratio of the medicine are as follows：120~250g of Sculellaria barbata, 30~60g of subprostrate sophora, 150~550g of dandelion, 90~160g of Radix Isatidis, 80~160g of Angelica sinensis, 250~1000g of oldenlandia diffusa, 30~120g of radix bupleuri, 30~120g of curcuma zedoary, 60~120g of rhizoma alismatis；Medicine provided by the invention is a good Chinese prescription.

Description

It is a kind of to be used to treat pill medicine of cervical carcinoma and preparation method thereof
Technical field
The invention belongs to field of traditional Chinese, and in particular to a kind of pill medicine for being used to treat cervical carcinoma, particularly supplies The field of the pill medicine that cervical cancer patient uses and preparation method thereof.
Background technology
Doctor thinks：Cervical carcinoma, cervical carcinoma refer to occur in ectocervical or the squamous cell and neck of transitional zone The malignant tumour of the columnar epithelial cell intersection of pipe inner membrance, cervical carcinoma are uterus most commonly seen in feminine proses Neck malignant tumor, its clinical manifestation are：Menstruation or leukorrhea, the irregular bleeding of vagina, waist and belly pain, anaemia, disappear It is thin to wait cachexia symptom.
In recent years, the incidence of cervical carcinoma is in rising trend, and morbidity crowd is also gradually developed to rejuvenation.Long-term clinic Viewpoint thinks：The susceptibility of Chemotherapy of Cervical Cancer is poor, effective percentage below 15% or so, and the chemotherapeutics of cervical carcinoma can be adopted at present With 5- fluorine urine crash steep, adriamycin etc. into row vein or local injection, but toxicity of adriamycin reaction is heavier, and is sent out in zoopery Existing carcinogenesis, there are potential carcinogenic substance in human body, has a significant impact reproductive function.And current operation plan is Cancerous issue and chemicotherapy are cut off, and the actual bodily harm to women is very big.And Chinese medicine treatment has Small side effects, anti-recurrence rate effect The advantages of fruit is good, can preferably stablize the state of an illness, be not easy to spread.
So, just how to find a kind of Chinese medicine composition that can effectively treat cervical carcinoma, be those skilled in the art urgently Solve the problems, such as.
The content of the invention
With the continuous development of China's traditional Chinese medicine, in treatment cervical carcinoma, people gradually appreciate Chinese traditional treatment The advantages of cervical carcinoma, and good effect, the advantage such as quick, toxic side effect is small over the course for the treatment of, for existing western medical treatment palace The present situation of neck cancer, the purpose of the invention is to provide a kind of pill medicine for being used to treat cervical carcinoma, to solve cervical carcinoma trouble The problem of person gets well and improves the quality of living early.The medicine is using common Chinese medicine as raw material, by selecting reasonably Medicine and mass parts ratio, can effectively treat above-mentioned cervical carcinoma.
To achieve the purpose that foregoing invention, the technical solution adopted in the present invention is：There is provided a kind of for treating cervical carcinoma Pill medicine and preparation method thereof, it is characterised in that each component and mass parts of the medicine are than as follows：
120~250g of Sculellaria barbata, 30~60g of subprostrate sophora, 150~550g of dandelion, 90~160g of Radix Isatidis, Angelica sinensis 80~ 160g, 250~1000g of oldenlandia diffusa, 30~120g of radix bupleuri, 30~120g of curcuma zedoary, 60~120g of rhizoma alismatis, auxiliary material：Starch is fitted Amount.
It is a kind of to be used to treat pill medicine of cervical carcinoma and preparation method thereof, it is characterised in that each group of the medicine Divide and mass parts are than as follows：
135~220g of Sculellaria barbata, 38~52g of subprostrate sophora, 180~480g of dandelion, 100~140g of Radix Isatidis, Angelica sinensis 90~ 140g, 280~850g of oldenlandia diffusa, 38~105g of radix bupleuri, 38~105g of curcuma zedoary, 70~105g of rhizoma alismatis, auxiliary material：Starch is fitted Amount.
It is a kind of to be used to treat pill medicine of cervical carcinoma and preparation method thereof, it is characterised in that each group of the medicine Divide and mass parts are than as follows：
Sculellaria barbata 200g, subprostrate sophora 45g, dandelion 420g, Radix Isatidis 120g, Angelica sinensis 120g, oldenlandia diffusa 750g, radix bupleuri 95g, curcuma zedoary 95g, rhizoma alismatis 95g, auxiliary material：Appropriate starch.
It is a kind of to be used to treat pill medicine of cervical carcinoma and preparation method thereof, it is characterised in that the described method includes as follows Step is prepared：
A, in addition to starch, after above-mentioned raw materials Chinese medicine is picked impurity, dust and drying, it is ground into superfine end according to mass parts ratio and treats With；
B, the method for preparing Chinese kmedicine bolus agent according to tradition, after ground superfine myrrh thing and starch are sieved, is put into medicine device Middle mixing is mixed, is then prepared into water-bindered pill agent（The granularity of its water-bindered pill is：3.9mm~4.0mm）, and then dry, sealed packaging is .
It is a kind of to be used to treat pill medicine of cervical carcinoma and preparation method thereof, it is characterised in that the instructions of taking is：Will The water pill medicine prepared is twice a day to take, morning and evening service once, and dosage 6g/time, warm water delivery service.It is within 30 days One course for the treatment of, take medicine 2 courses for the treatment of after, symptom substantially mitigates, colporrhagia amount reduce.Advise to renew and take 3~4 courses for the treatment of, symptom is bright It is aobvious to mitigate.
Each raw material Chinese medicine in prescription of the present invention has detailed note in Chinese Pharmacopoeia, Chinese dictionary and China's book on Chinese herbal medicine Carry.It is raw material that the present invention, which selects one of the most common Chinese medicine, gives full play to the pharmacological effect of each component：
Sculellaria barbata, nature and flavor：It is acrid flavour, hardship, cold in nature, there is the effect of heat-clearing, removing toxic substances, scattered stasis of blood, hemostasis, inducing diuresis to remove edema, analgesic therapy, be used for Treatment haematemesis, bleeding from five sense organs or subcutaneous tissue, blood strangury, dysentery characterized by blood in the stool, jaundice, have sore throat, lung carbuncle, furunculosis, scrofula, sore, cancerous swelling, bruise knife wound, snake sting Wound；
Subprostrate sophora, nature and flavor：It is bitter, cold, it is poisonous, there is the effect of clearing heat and detoxicating, detumescence relieving sore-throat, pented up for treating fiery poison, throat Swelling and pain, gingivitis；
Dandelion, nature and flavor：Sweet, slight bitter, tremble with fear, and has the effect of clearing heat and detoxicating, carbuncle that disappears dissipating bind, swollen for treatmentization heat toxin, the evil that disappears Tuberculosis, Detoxicating food-poisoning, dissipate stagnant gas；
Radix Isatidis, nature and flavor：It is bitter, cold, there is the effect of clearing heat and detoxicating, cool blood, relieving sore-throat, poison during for treating warm epidemic disease, fever pharyngalgia, The diseases such as febrile virulent maculae, mumps, scarlet fever, major part pestilence, erysipelas, carbuncle swells；
Angelica sinensis, nature and flavor：It is sweet in flavor, pungent, slight bitter, warm-natured, there is the effect of benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturize laxation, for treating Irregular menstruation, Amenorrhea abdominal pain, Disorder lump in the abdomen knots gather, uterine bleeding, headache due to deficiency of blood, dizziness, Impotence numbness, intestines are dry and shit is difficult, after dysentery characterized by blood in the stool weight, ulcer sore Surreptitiously, the illness such as injury from falling down；
Oldenlandia diffusa, nature and flavor：It is sweet, light, cool, there is the effect of clearing heat and detoxicating, inducing diuresis to remove edema, promoting blood circulation and stopping pain, for treating intestines Carbuncle（Appendicitis）, sore furuncle poison, jaundice with damp-heat pathogen, disease, the external application such as difficult urination control boil carbuncle swells, venomous snake bite；
Radix bupleuri, nature and flavor：Bitter, pungent, cold nature, there is inducing diaphoresis to bring down a fever, soothing liver-qi stagnation, rise the effect of lifting yang-energy, outer for treating Feel fever, fevers and chills alternate, malaria, liver-depressed hypochondrium pain mammary swelling, have a headache a dizzy, irregular menstruation, the rectal prolapse of collapse from qi deficiency, the prolapse of uterus, The diseases such as gastroptosis；
Curcuma zedoary, nature and flavor：Toil, temperature, have the effect of blood-breaking, Xiao Ji Zhi Tong, for treat pained vim and vigour, eating accumulation, Abdominal distention, amenorrhea due to stagnation of blood, dysmenorrhoea, abdominal mass knurl lump in the abdomen, traumatic injury, be additionally operable to abdominal pain due to blood stasis, hepatosplenomegaly, trusted subordinate's distending pain, Accumulation, abdominal mass lump, women's blood stasis, traumatic injury are had a pain eating accumulation, and it is antitumor that modern pharmacology shows that oriental wormwood has Effect：Its aromatic turmeric oil preparation is in vitro to the L615 leukaemia and ascitic type of Mouse Ehrlich Carcinoma Cells, 615 mouse inbred lines The growth of a variety of knurl strains such as liver cancer cells has obvious suppression and destruction.Clinic makees intratumoral injection uterine neck with oil of zedoary turmeric Cancer, after treatment visible tumor tissue necrosis come off, local lymphocytes infiltration, some cases lump disappear, uterine neck is smooth, prompt cowherb Art plays the role of directly killing oncocyte；
Rhizoma alismatis, nature and flavor：It is sweet in flavor, light, cold in nature, have clearing damp and promoting diuresis, expel the heat-evil, change the effect of turbid lipid-loweringing, for treat difficult urination, The diseases such as oedema turgor, oliguria of having loose bowels, phlegmatic vertigo, puckery pain of heat gonorrhea, hyperlipidemia.
Medicine of the present invention is the principle based on Chinese traditional treatment cervical carcinoma, from the pathomechanism according to cervical carcinoma and pharmacological action Think：With regard to cervical carcinoma, each raw material herbal medicine efficacy in medicine provided by the present invention is played altogether, has good treatment to above-mentioned disease Effect.
Embodiment
A kind of Chinese medicine preparation that the present invention is proposed aiming at the treatment of above-mentioned cervical carcinoma, the medicine prepared using the formula Thing good drug efficacy, it is quick, it is a good Chinese prescription, is particularly suitable for Clinical practice.With reference to the specific reality of the present invention The mode of applying is described in further detail：
Embodiment 1：
A kind of pill medicine for being used to treat cervical carcinoma, it is characterised in that each component and mass parts ratio of the medicine are as follows It is shown：
Sculellaria barbata 200g, subprostrate sophora 45g, dandelion 420g, Radix Isatidis 120g, Angelica sinensis 120g, oldenlandia diffusa 750g, radix bupleuri 95g, curcuma zedoary 95g, rhizoma alismatis 95g, auxiliary material：Appropriate starch.
Embodiment 2：
A kind of pill medicine for being used to treat cervical carcinoma, it is characterised in that each component and mass parts ratio of the medicine are as follows It is shown：
Sculellaria barbata 220g, subprostrate sophora 52g, dandelion 480g, Radix Isatidis 140g, Angelica sinensis 140g, oldenlandia diffusa 850g, radix bupleuri 105g, curcuma zedoary 105g, rhizoma alismatis 105g, auxiliary material：Appropriate starch.
Embodiment 3：
A kind of pill medicine for being used to treat cervical carcinoma, it is characterised in that each component and mass parts ratio of the medicine are as follows It is shown：
Sculellaria barbata 1250g, subprostrate sophora 60g, dandelion 550g, Radix Isatidis 160g, Angelica sinensis 160g, oldenlandia diffusa 1000g, radix bupleuri 120g, curcuma zedoary 120g, rhizoma alismatis 120g, auxiliary material：Appropriate starch.
Model case
Through clinical conditions cervical cancer patient totally 1380, the age is 735 of more than 49 years old, only 645 be 49 years old with Under.Symptom disappears substantially in 1380 patients 721, effective 355, invalid 304.Total effective rate is up to 78%.

Claims (3)

  1. A kind of 1. pill medicine for being used to treat cervical carcinoma, it is characterised in that each component and its mass parts ratio of the medicine It is as follows：
    120~250g of Sculellaria barbata, 30~60g of subprostrate sophora, 150~550g of dandelion, 90~160g of Radix Isatidis, Angelica sinensis 80~ 160g, 250~1000g of oldenlandia diffusa, 30~120g of radix bupleuri, 30~120g of curcuma zedoary, 60~120g of rhizoma alismatis, auxiliary material：Starch is fitted Amount.
  2. 2. the pill medicine according to claim 1 for being used to treat cervical carcinoma, it is characterised in that each group of the medicine Divide and its mass parts are than as follows：
    135~220g of Sculellaria barbata, 38~52g of subprostrate sophora, 180~480g of dandelion, 100~140g of Radix Isatidis, Angelica sinensis 90~ 140g, 280~850g of oldenlandia diffusa, 38~105g of radix bupleuri, 38~105g of curcuma zedoary, 70~105g of rhizoma alismatis, auxiliary material：Starch is fitted Amount.
  3. 3. being used for according to claim 1 to 2 treats the pill medicine of cervical carcinoma, it is characterised in that the medicine it is each A component and its mass parts are than as follows：
    Sculellaria barbata 200g, subprostrate sophora 45g, dandelion 420g, Radix Isatidis 120g, Angelica sinensis 120g, oldenlandia diffusa 750g, radix bupleuri 95g, curcuma zedoary 95g, rhizoma alismatis 95g, auxiliary material：Appropriate starch.
CN201711102343.9A 2017-11-10 2017-11-10 It is a kind of to be used to treat pill medicine of cervical carcinoma and preparation method thereof Withdrawn CN107982476A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111759985A (en) * 2019-04-18 2020-10-13 四川靓健大健康科技有限公司 Traditional Chinese medicine for treating cervical cancer and preparation method thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111759985A (en) * 2019-04-18 2020-10-13 四川靓健大健康科技有限公司 Traditional Chinese medicine for treating cervical cancer and preparation method thereof

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