CN107438614B - 杂环化合物及它们在预防或治疗细菌感染中的应用 - Google Patents

杂环化合物及它们在预防或治疗细菌感染中的应用 Download PDF

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Publication number
CN107438614B
CN107438614B CN201680020682.XA CN201680020682A CN107438614B CN 107438614 B CN107438614 B CN 107438614B CN 201680020682 A CN201680020682 A CN 201680020682A CN 107438614 B CN107438614 B CN 107438614B
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formula
nhq
compounds
pharmaceutical composition
compound
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Chinese (zh)
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CN107438614A (zh
Inventor
朱莉·布利亚
索菲·查赛特
弗朗西斯·切弗勒依
尼古拉·莱科因特
伯诺瓦·勒杜萨尔
弗雷德里克·勒斯塔特
苏菲·沃米思德
塞巴斯蒂安·理查德
法比安·费弗尔
朱利安·巴比欧
奥德丽·卡拉瓦诺
杰拉尔丁·勒弗拉里克
克利斯朵夫·西蒙
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Baioudimu Co
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Baioudimu Co
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Priority claimed from EP15305508.2A external-priority patent/EP3075381A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/18—Bridged systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN201680020682.XA 2015-04-03 2016-04-01 杂环化合物及它们在预防或治疗细菌感染中的应用 Active CN107438614B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP15305508.2A EP3075381A1 (en) 2015-04-03 2015-04-03 Heterocyclic compounds and their use in preventing or treating bacterial infections
EP15305508.2 2015-04-03
EP16305069.3 2016-01-26
EP16305069 2016-01-26
PCT/EP2016/057274 WO2016156597A1 (en) 2015-04-03 2016-04-01 Heterocyclic compounds and their use in preventing or treating bacterial infections

Publications (2)

Publication Number Publication Date
CN107438614A CN107438614A (zh) 2017-12-05
CN107438614B true CN107438614B (zh) 2020-01-31

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CN201680020682.XA Active CN107438614B (zh) 2015-04-03 2016-04-01 杂环化合物及它们在预防或治疗细菌感染中的应用

Country Status (14)

Country Link
US (1) US10501481B2 (enExample)
EP (1) EP3277277B1 (enExample)
JP (1) JP2018510198A (enExample)
KR (1) KR20170132316A (enExample)
CN (1) CN107438614B (enExample)
AU (1) AU2016239861A1 (enExample)
BR (1) BR112017020935A2 (enExample)
CA (1) CA2980395A1 (enExample)
CL (1) CL2017002482A1 (enExample)
MX (1) MX2017012545A (enExample)
RU (1) RU2714197C2 (enExample)
TW (1) TW201639854A (enExample)
WO (1) WO2016156597A1 (enExample)
ZA (1) ZA201706348B (enExample)

Families Citing this family (15)

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Publication number Priority date Publication date Assignee Title
TWI720451B (zh) 2014-02-13 2021-03-01 美商英塞特控股公司 作為lsd1抑制劑之環丙胺
US9527835B2 (en) 2014-02-13 2016-12-27 Incyte Corporation Cyclopropylamines as LSD1 inhibitors
KR102421235B1 (ko) 2014-02-13 2022-07-15 인사이트 코포레이션 Lsd1 저해제로서 사이클로프로필아민
TWI687419B (zh) 2014-07-10 2020-03-11 美商英塞特公司 作為ｌｓｄ１抑制劑之咪唑并吡啶及咪唑并吡嗪
WO2016007722A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Triazolopyridines and triazolopyrazines as lsd1 inhibitors
TW201613925A (en) 2014-07-10 2016-04-16 Incyte Corp Imidazopyrazines as LSD1 inhibitors
SG11201708047UA (en) 2015-04-03 2017-10-30 Incyte Corp Heterocyclic compounds as lsd1 inhibitors
CN110402244B (zh) 2015-08-12 2023-02-03 因赛特公司 Lsd1抑制剂的盐
JOP20190061A1 (ar) * 2016-09-28 2019-03-26 Novartis Ag مثبطات بيتا-لاكتاماز
EP3300736B1 (en) * 2016-09-30 2021-05-05 Mutabilis Composition comprising antibiotic compound and an heterocyclic compound and their use in preventing or treating bacterial infections
EP3357924A1 (en) 2017-02-06 2018-08-08 Mutabilis Novel heterocyclic compounds and their use in preventing or treating bacterial infections
EP3604315A1 (en) 2018-07-30 2020-02-05 Mutabilis Heterocyclic compounds and their use in preventing or treating bacterial infections
ES2960952T3 (es) 2018-08-09 2024-03-07 Antabio Sas Diazabiciclooctanonas como inhibidores de serina beta-lactamasas
US11905286B2 (en) 2018-08-09 2024-02-20 Antabio Sas Diazabicyclooctanones as inhibitors of serine beta-lactamases
WO2020047198A1 (en) 2018-08-31 2020-03-05 Incyte Corporation Salts of an lsd1 inhibitor and processes for preparing the same

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040009234A1 (en) * 2002-07-10 2004-01-15 Meisel Gerard M. Gastrointestinal compositions
CN101248073A (zh) * 2005-08-22 2008-08-20 塔加西普特公司 杂芳基-取代的二氮杂三环烷类、其制备方法及其应用
CN101932579A (zh) * 2007-03-23 2010-12-29 拜欧蒂姆实验室公司 具有抗菌性质的新的咪唑并-杂芳基衍生物
CN102203094A (zh) * 2008-10-03 2011-09-28 诺韦克塞尔公司 新颖的含氮杂环化合物，其制备及其作为抗菌药物的用途
CN104364254A (zh) * 2012-04-02 2015-02-18 阿斯利康(瑞典)有限公司 作为β-内酰胺酶抑制剂的杂二环化合物

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SU1107541A1 (ru) * 1982-12-03 1995-10-20 Институт Тонкой Органической Химии Им.А.Л.Мнджояна 10-нитро-1,6,8-триазатрицикло [6,3,1,1] тридекан-2,5-дион
ES2127946T3 (es) 1993-12-29 1999-05-01 Pfizer Antagonistas de neurocinina diazabiciclica.
FR2825705B1 (fr) 2001-06-08 2005-05-20 Aventis Pharma Sa Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens
FR2937034B1 (fr) * 2008-10-10 2012-11-23 Novexel Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens
WO2014141132A1 (en) 2013-03-14 2014-09-18 Naeja Pharmaceutical Inc. NEW HETEROCYCLIC COMPOUNDS AND THEIR USE AS ANTIBACTERIAL AGENTS AND β-LACTAMASE INHIBITORS

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040009234A1 (en) * 2002-07-10 2004-01-15 Meisel Gerard M. Gastrointestinal compositions
CN101248073A (zh) * 2005-08-22 2008-08-20 塔加西普特公司 杂芳基-取代的二氮杂三环烷类、其制备方法及其应用
CN101932579A (zh) * 2007-03-23 2010-12-29 拜欧蒂姆实验室公司 具有抗菌性质的新的咪唑并-杂芳基衍生物
CN102203094A (zh) * 2008-10-03 2011-09-28 诺韦克塞尔公司 新颖的含氮杂环化合物，其制备及其作为抗菌药物的用途
CN104364254A (zh) * 2012-04-02 2015-02-18 阿斯利康(瑞典)有限公司 作为β-内酰胺酶抑制剂的杂二环化合物

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Publication number Publication date
MX2017012545A (es) 2018-09-28
CN107438614A (zh) 2017-12-05
EP3277277B1 (en) 2021-01-06
CL2017002482A1 (es) 2018-04-20
AU2016239861A1 (en) 2017-10-12
US20180118765A1 (en) 2018-05-03
JP2018510198A (ja) 2018-04-12
CA2980395A1 (en) 2016-10-06
EP3277277A1 (en) 2018-02-07
RU2714197C2 (ru) 2020-02-13
KR20170132316A (ko) 2017-12-01
ZA201706348B (en) 2019-11-27
WO2016156597A1 (en) 2016-10-06
TW201639854A (zh) 2016-11-16
RU2017134055A3 (enExample) 2019-08-30
RU2017134055A (ru) 2019-04-03
US10501481B2 (en) 2019-12-10
BR112017020935A2 (pt) 2018-07-10

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