CN107429297A - 用于检测细菌核酸和诊断细菌性阴道病的方法和组合物 - Google Patents

用于检测细菌核酸和诊断细菌性阴道病的方法和组合物 Download PDF

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CN107429297A
CN107429297A CN201680018451.5A CN201680018451A CN107429297A CN 107429297 A CN107429297 A CN 107429297A CN 201680018451 A CN201680018451 A CN 201680018451A CN 107429297 A CN107429297 A CN 107429297A
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lactobacillus
seq
specific
nucleotide sequence
target
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Chinese (zh)
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B·L·伊顿
D·K·格特曼
T·帕夫洛夫斯基
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Gen Probe Inc
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Gen Probe Inc
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6865Promoter-based amplification, e.g. nucleic acid sequence amplification [NASBA], self-sustained sequence replication [3SR] or transcription-based amplification system [TAS]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/112Disease subtyping, staging or classification
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    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers
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    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/16Primer sets for multiplex assays
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    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/166Oligonucleotides used as internal standards, controls or normalisation probes

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201680018451.5A 2015-03-16 2016-03-16 用于检测细菌核酸和诊断细菌性阴道病的方法和组合物 Withdrawn CN107429297A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201562133881P 2015-03-16 2015-03-16
US62/133,881 2015-03-16
US201562168405P 2015-05-29 2015-05-29
US201562168688P 2015-05-29 2015-05-29
US62/168,688 2015-05-29
US62/168,405 2015-05-29
PCT/US2016/022628 WO2016149357A1 (en) 2015-03-16 2016-03-16 Methods and compositions for detecting bacterial nucleic acid and diagnosing bacterial vaginosis

Publications (1)

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CN107429297A true CN107429297A (zh) 2017-12-01

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CN201680018451.5A Withdrawn CN107429297A (zh) 2015-03-16 2016-03-16 用于检测细菌核酸和诊断细菌性阴道病的方法和组合物

Country Status (7)

Country Link
US (3) US10550438B2 (https=)
EP (2) EP3271484B1 (https=)
JP (3) JP6796593B2 (https=)
CN (1) CN107429297A (https=)
AU (2) AU2016233298B2 (https=)
CA (1) CA2977821A1 (https=)
WO (1) WO2016149357A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110283921A (zh) * 2019-07-12 2019-09-27 中生方政生物技术股份有限公司 加德纳杆菌、白色念珠菌双重检测的引物、探针组、试剂盒及检测方法
WO2023202027A1 (zh) * 2022-04-18 2023-10-26 北京起源聚禾生物科技有限公司 阴道微生态检测引物探针组合及试剂盒

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10550438B2 (en) * 2015-03-16 2020-02-04 Gen-Probe Incorporated Methods and compositions for detecting bacterial nucleic acid
WO2019026884A1 (ja) * 2017-07-31 2019-02-07 凸版印刷株式会社 核酸検出方法および検出用試薬
CA3101173A1 (en) * 2018-05-23 2019-11-28 Ko Biolabs, Inc. Lactobacillus crispatus kbl693 strain and use thereof
US20220047653A1 (en) * 2018-08-10 2022-02-17 The Regents Of The University Of California Methods and compositions for treating and preventing inflammatory diseases
JP7389111B2 (ja) * 2018-08-24 2023-11-29 ジェン-プローブ・インコーポレーテッド 細菌の核酸を検出し、細菌性膣炎を診断するための組成物および方法
WO2020166708A1 (ja) * 2019-02-15 2020-08-20 コンビ株式会社 新規乳酸菌およびそれを含有する組成物
US20220205020A1 (en) * 2020-12-30 2022-06-30 Roche Molecular Systems, Inc. Compositions and methods for detection of bacteria and fungi associated with bacterial and candida vaginosis
EP4317511A4 (en) * 2021-04-02 2024-10-02 Baoshan Iron & Steel Co., Ltd. Low-carbon low-alloy q&p steel or hot-dip galvanized q&p steel with tensile strength greater than or equal to 1180 mpa, and manufacturing method therefor
EP4289964A4 (en) 2022-04-18 2024-10-09 Beijing OriginPoly Bio-Tec Co., Ltd. PRIMER-PROBE COMBINATION AND KIT FOR VAGINAL MICROECOSYSTEM DETECTION
WO2024006762A1 (en) * 2022-06-27 2024-01-04 The Uab Research Foundation Nucleic acid probes and their uses for the detection of prevotella bivia

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2422956A1 (fr) 1978-04-13 1979-11-09 Pasteur Institut Procede de detection et de caracterisation d'un acide nucleique ou d'une sequence de celui-ci, et reactif enzymatique pour la mise en oeuvre de ce procede
US4786600A (en) 1984-05-25 1988-11-22 The Trustees Of Columbia University In The City Of New York Autocatalytic replication of recombinant RNA
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4868105A (en) 1985-12-11 1989-09-19 Chiron Corporation Solution phase nucleic acid sandwich assay
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
WO1988001302A1 (en) 1986-08-11 1988-02-25 Siska Diagnostics, Inc. Nucleic acid probe assay methods and compositions
US5541308A (en) 1986-11-24 1996-07-30 Gen-Probe Incorporated Nucleic acid probes for detection and/or quantitation of non-viral organisms
IL86724A (en) 1987-06-19 1995-01-24 Siska Diagnostics Inc Methods and kits for amplification and testing of nucleic acid sequences
WO1989001050A1 (en) 1987-07-31 1989-02-09 The Board Of Trustees Of The Leland Stanford Junior University Selective amplification of target polynucleotide sequences
US5639604A (en) 1987-09-21 1997-06-17 Gen-Probe Incorporated Homogeneous protection assay
US5585481A (en) 1987-09-21 1996-12-17 Gen-Probe Incorporated Linking reagents for nucleotide probes
DE3854029T2 (de) 1987-09-21 1995-10-26 Gen Probe Inc Homogener Abschirmungstest.
US5283174A (en) 1987-09-21 1994-02-01 Gen-Probe, Incorporated Homogenous protection assay
US5124246A (en) 1987-10-15 1992-06-23 Chiron Corporation Nucleic acid multimers and amplified nucleic acid hybridization assays using same
US5130238A (en) 1988-06-24 1992-07-14 Cangene Corporation Enhanced nucleic acid amplification process
US5118801A (en) 1988-09-30 1992-06-02 The Public Health Research Institute Nucleic acid process containing improved molecular switch
US5656207A (en) 1989-06-24 1997-08-12 Gen Probe Incorporated Detecting or quantifying multiple analytes using labelling techniques
CA2020958C (en) 1989-07-11 2005-01-11 Daniel L. Kacian Nucleic acid sequence amplification methods
US5516663A (en) 1990-01-26 1996-05-14 Abbott Laboratories Ligase chain reaction with endonuclease IV correction and contamination control
US5427930A (en) 1990-01-26 1995-06-27 Abbott Laboratories Amplification of target nucleic acids using gap filling ligase chain reaction
US5849481A (en) 1990-07-27 1998-12-15 Chiron Corporation Nucleic acid hybridization assays employing large comb-type branched polynucleotides
US5378825A (en) 1990-07-27 1995-01-03 Isis Pharmaceuticals, Inc. Backbone modified oligonucleotide analogs
US5846717A (en) 1996-01-24 1998-12-08 Third Wave Technologies, Inc. Detection of nucleic acid sequences by invader-directed cleavage
JP3131222B2 (ja) 1991-12-24 2001-01-31 アイシス・ファーマシューティカルス・インコーポレーテッド ギャップを有する2′修飾オリゴヌクレオチド
US5424413A (en) 1992-01-22 1995-06-13 Gen-Probe Incorporated Branched nucleic acid probes
KR100249110B1 (ko) 1992-05-06 2000-04-01 다니엘 엘. 캐시앙 핵산 서열 증폭 방법, 이에 이용되는 조성물 및 키트
US5614402A (en) 1992-12-07 1997-03-25 Third Wave Technologies, Inc. 5' nucleases derived from thermostable DNA polymerase
US5422252A (en) 1993-06-04 1995-06-06 Becton, Dickinson And Company Simultaneous amplification of multiple targets
WO1995003430A1 (en) 1993-07-23 1995-02-02 Gen-Probe Incorporated Methods for enhancing nucleic acid amplification
US5925517A (en) 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
US5547861A (en) 1994-04-18 1996-08-20 Becton, Dickinson And Company Detection of nucleic acid amplification
US5648211A (en) 1994-04-18 1997-07-15 Becton, Dickinson And Company Strand displacement amplification using thermophilic enzymes
JPH10500310A (ja) 1994-05-19 1998-01-13 ダコ アクティーゼルスカブ 淋菌及びトラコーマ クラミジアの検出のためのpna プローブ
DE69535240T2 (de) 1994-10-28 2007-06-06 Gen-Probe Inc., San Diego Zusammensetzungen und Verfahren für die gleichzeitige Detektion und Quantifizierung von einer Mehrheit spezifischer Nuklein Säure Sequenzen
US6218529B1 (en) * 1995-07-31 2001-04-17 Urocor, Inc. Biomarkers and targets for diagnosis, prognosis and management of prostate, breast and bladder cancer
US6706471B1 (en) 1996-01-24 2004-03-16 Third Wave Technologies, Inc. Detection of nucleic acid sequences by invader-directed cleavage
AU713667B2 (en) 1996-04-12 1999-12-09 Phri Properties, Inc. Detection probes, kits and assays
EP0975807B1 (en) 1997-05-02 2006-09-27 Gen-Probe Incorporated Two-step hybridization and capture of a polynucleotide
US6534273B2 (en) 1997-05-02 2003-03-18 Gen-Probe Incorporated Two-step hybridization and capture of a polynucleotide
US6180340B1 (en) 1997-10-31 2001-01-30 Gen-Probe Incorporated Extended dynamic range assays
US6949367B1 (en) 1998-04-03 2005-09-27 Epoch Pharmaceuticals, Inc. Modified oligonucleotides for mismatch discrimination
AU762728B2 (en) 1998-07-02 2003-07-03 Gen-Probe Incorporated Molecular torches
US7829079B2 (en) 2002-03-28 2010-11-09 Christian Hansen A/S Lactobacillus iners for the enhancement of urogenital health
US20040022764A1 (en) * 2002-07-31 2004-02-05 Hanan Polansky Inhibition of microcompetition with a foreign polynucleotide as treatment of chronic disease
CA2572472C (en) 2004-07-01 2013-08-13 Gen-Probe Incorporated Methods and compositions to detect nucleic acids in a biological sample
CA2957197C (en) 2004-08-27 2017-12-12 Gen-Probe Incorporated Single-primer nucleic acid amplification methods
US7627437B2 (en) 2005-01-14 2009-12-01 Idaho Research Foundation Categorization of microbial communities
US20060194240A1 (en) 2005-02-28 2006-08-31 Gen-Probe Incorporated Compositions and methods of detecting an analyte by using a nucleic acid hybridization switch probe
US7625704B2 (en) 2005-08-31 2009-12-01 Fred Hutchinson Cancer Research Center Methods and compositions for identifying bacteria associated with bacteria vaginosis
US9051601B2 (en) 2006-08-01 2015-06-09 Gen-Probe Incorporated Methods of nonspecific target capture of nucleic acids
FR2909099B1 (fr) 2006-11-24 2012-10-19 Univ Aix Marseille Ii Methode de diagnostic et de suivi d'une vaginose bacterienne par quantification moleculaire.
EP2188632A4 (en) 2007-09-10 2010-11-10 Becton Dickinson Co APPARATUS AND METHODS FOR DIAGNOSING BACTERIAL VAGINOSIS
EP3321380B1 (en) * 2009-12-03 2023-09-06 Quest Diagnostics Investments Incorporated Methods for the diagnosis of bacterial vaginosis
EP3040425B1 (en) * 2010-02-17 2019-08-28 Gen-Probe Incorporated Compostions and methods to detect atopobium vaginae nucleic acid
WO2012149034A1 (en) * 2011-04-25 2012-11-01 Gen-Probe Incorporated Compositions and methods for detecting bv-associated bacterial nucleic acid
EP3009522B1 (en) * 2011-07-15 2019-09-04 Gen-Probe Incorporated Method for detecting hepatitis a virus nucleic acids in single-plex or multiplex assays
WO2013036928A1 (en) * 2011-09-08 2013-03-14 Gen-Probe Incorporated Compositions and methods for detecting bv-associated bacterial nucleic acid
US9970060B2 (en) 2011-11-23 2018-05-15 Medical Diagnostic Laboratories, Llc Quantitation and profiling of vaginal microflora
CA2806382C (en) 2012-02-20 2021-11-23 Laboratory Corporation Of America Holdings Diagnostic methods and markers for bacterial vaginosis
US10550438B2 (en) * 2015-03-16 2020-02-04 Gen-Probe Incorporated Methods and compositions for detecting bacterial nucleic acid
JP7389111B2 (ja) * 2018-08-24 2023-11-29 ジェン-プローブ・インコーポレーテッド 細菌の核酸を検出し、細菌性膣炎を診断するための組成物および方法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ELENA SHIPITSYNA等: "Composition of the Vaginal Microbiota in Women of Reproductive Age – Sensitive and Specific Molecular Diagnosis of Bacterial Vaginosis Is Possible?", 《PLOS ONE.》 *
FREDRICKS等: "Targeted PCR for detection of vaginal bacteria associated with bacterial vaginosis", 《J CLIN MICROBIOL》 *
M. REZA ZARI¡ARD等: ""Detection of bacterial vaginosis-related organisms by real-time PCR for Lactobacilli, Gardnerella vaginalis and Mycoplasma hominis"", 《FEMS IMMUNOL MED MICROBIOL.》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110283921A (zh) * 2019-07-12 2019-09-27 中生方政生物技术股份有限公司 加德纳杆菌、白色念珠菌双重检测的引物、探针组、试剂盒及检测方法
WO2023202027A1 (zh) * 2022-04-18 2023-10-26 北京起源聚禾生物科技有限公司 阴道微生态检测引物探针组合及试剂盒

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AU2016233298A1 (en) 2017-09-14
JP6970268B2 (ja) 2021-11-24
AU2021277704A1 (en) 2021-12-23
JP2018508225A (ja) 2018-03-29
US12031187B2 (en) 2024-07-09
JP2022025106A (ja) 2022-02-09
US20180291430A1 (en) 2018-10-11
US20200109444A1 (en) 2020-04-09
EP3271484A1 (en) 2018-01-24
WO2016149357A1 (en) 2016-09-22
AU2016233298B2 (en) 2021-09-02
CA2977821A1 (en) 2016-09-22
JP6796593B2 (ja) 2020-12-09
US11268156B2 (en) 2022-03-08
EP3910075C0 (en) 2024-12-11
AU2021277704B2 (en) 2022-04-28
US10550438B2 (en) 2020-02-04
EP3910075A1 (en) 2021-11-17
EP3271484B1 (en) 2021-06-02
JP2021035391A (ja) 2021-03-04
EP3271484A4 (en) 2018-11-14
US20210277451A1 (en) 2021-09-09
EP3910075B1 (en) 2024-12-11

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