CN107428718A - 布瑞哌唑类似物的制备方法 - Google Patents

布瑞哌唑类似物的制备方法 Download PDF

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Publication number
CN107428718A
CN107428718A CN201680004617.8A CN201680004617A CN107428718A CN 107428718 A CN107428718 A CN 107428718A CN 201680004617 A CN201680004617 A CN 201680004617A CN 107428718 A CN107428718 A CN 107428718A
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China
Prior art keywords
sodium
formula
potassium
compound
dimethyl
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CN201680004617.8A
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CN107428718B (zh
Inventor
张健
田广辉
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Suzhou Wangshan Wangshui Biopharmaceutical Co ltd
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Suzhou Vigonvita Life Sciences Co ltd
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Publication of CN107428718A publication Critical patent/CN107428718A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

本发明涉及布瑞哌唑类似物及其制备方法。所述制备方法操作简单易行、工艺稳定、易于控制、反应后处理方便、不对人体健康与环境产生危害、生产成本低、收率高、纯度好，适于大规模生产。

Description

PCT国内申请，说明书已公开。

Claims (14)

  1. PCT国内申请，权利要求书已公开。
CN201680004617.8A 2015-02-05 2016-02-04 布瑞哌唑类似物的制备方法 Active CN107428718B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201510061026.1A CN105985314A (zh) 2015-02-05 2015-02-05 布瑞哌唑类似物的制备方法
CN2015100610261 2015-02-05
PCT/CN2016/073428 WO2016124144A1 (zh) 2015-02-05 2016-02-04 布瑞哌唑类似物的制备方法

Publications (2)

Publication Number Publication Date
CN107428718A true CN107428718A (zh) 2017-12-01
CN107428718B CN107428718B (zh) 2021-04-27

Family

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CN201510061026.1A Pending CN105985314A (zh) 2015-02-05 2015-02-05 布瑞哌唑类似物的制备方法
CN201680004617.8A Active CN107428718B (zh) 2015-02-05 2016-02-04 布瑞哌唑类似物的制备方法

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CN201510061026.1A Pending CN105985314A (zh) 2015-02-05 2015-02-05 布瑞哌唑类似物的制备方法

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CN (2) CN105985314A (zh)
WO (1) WO2016124144A1 (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107915770B (zh) * 2016-10-11 2020-08-25 联宁（苏州）生物制药有限公司 一种抗体药物偶联物中间体及其制备方法
CN109307716B (zh) * 2017-07-27 2022-03-25 四川弘远药业有限公司 一种依匹哌唑有关物质的检测方法
CN114591326B (zh) * 2022-02-28 2024-02-27 上海筛杰生物医药有限公司 Cct-251921的中间体及其制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006112464A1 (en) * 2005-04-14 2006-10-26 Otsuka Pharmaceutical Co., Ltd. Piperazine-substituted benzothiophenes for treatment of mental disorders
CN104557896A (zh) * 2013-10-18 2015-04-29 沈敬山 布瑞哌唑、其关键中间体及其盐的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0732332B1 (en) * 1995-03-17 2001-12-19 Aventis Pharmaceuticals Inc. Substituted benzothienylpiperazines, their use as medicaments, and processes for their preparation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006112464A1 (en) * 2005-04-14 2006-10-26 Otsuka Pharmaceutical Co., Ltd. Piperazine-substituted benzothiophenes for treatment of mental disorders
CN104557896A (zh) * 2013-10-18 2015-04-29 沈敬山 布瑞哌唑、其关键中间体及其盐的制备方法

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Publication number Publication date
CN107428718B (zh) 2021-04-27
CN105985314A (zh) 2016-10-05
WO2016124144A1 (zh) 2016-08-11

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Address after: 215123 Floor 8, Building A, No. 108, Yuxin Road, Suzhou Industrial Park, Suzhou, China (Jiangsu) Pilot Free Trade Zone

Patentee after: Suzhou Wangshan Wangshui Biopharmaceutical Co.,Ltd.

Country or region after: China

Address before: 215123 10 building, 398 D, 398 water road, Suzhou Industrial Park, Suzhou, Jiangsu

Patentee before: SUZHOU VIGONVITA LIFE SCIENCES Co.,Ltd.

Country or region before: China