CN107428690B - 可用于治疗癌症的突变idh1抑制剂 - Google Patents

可用于治疗癌症的突变idh1抑制剂 Download PDF

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CN107428690B
CN107428690B CN201580076328.4A CN201580076328A CN107428690B CN 107428690 B CN107428690 B CN 107428690B CN 201580076328 A CN201580076328 A CN 201580076328A CN 107428690 B CN107428690 B CN 107428690B
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alkyl
phenyl
mixture
compound
radical
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CN107428690A (zh
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马修·布莱恩·博克瑟
杰森·马修·罗德
拉詹·普拉加尼
刘莉
曼迪·伊雷妮·艾米丽·戴维斯
凯勒·瑞恩·布里马科姆
沈敏
安东·西梅奥诺夫
苏伦德拉·卡拉瓦迪
丹尼尔·詹森·乌尔班
阿吉特·贾达夫
王晓东
安德鲁·路易斯·麦基弗
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University of North Carolina at Chapel Hill
United States Department of Health and Human Services
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United States Department of Health and Human Services
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

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