CN107412313A - A kind of composition for increasing diabetic's bone density and preparation method thereof - Google Patents
A kind of composition for increasing diabetic's bone density and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of composition for increasing diabetic's bone density, it is made up of the component of following parts by weight：2~5 parts of oligoisomaltose, 10~20 parts of skimmed milk power, 25~35 parts of enzymolysis bone calcium powder, 15~20 parts of pumpkin powder, 3~7 parts of polydextrose, 0.6~0.8 part of vitamin D, 0.3~0.4 part of ferrous lactate.The invention also discloses a kind of preparation method of above-mentioned composition, including preparation capsule core, enteric coated, unclassified stores coating to be prepared into micropill.It is improved using product one side mouthfeel made from preparation method of the present invention, the absorptivity of another aspect calcium product is greatly improved, and the significant effect for showing as the increase bone density of the micropill product obtained by technical solution of the present invention is better than the product of the equal other formulations for digesting bone calcium powder dosage.
Description
Technical field
The present invention relates to a kind of health food, especially a kind of composition for increasing diabetic's bone density and its preparation
Method.
Background technology
Osteoporosis be it is a kind of by bone amount reduce and bone tissue micro-structural extremely characterized by, cause skeletal fragility increase and
A kind of generalized metabolic osteopathy easily fractured.With socio-economic development and aging population, the trouble of osteoporosis
Sick rate rapidly increases, and harm is also further serious caused by osteoporosis and osteoporotic fracture.Diabetes are a kind of normal
The incretion metabolism disease seen, be it is a kind of involve the multiple systems of whole body and the chronic disease of organ, clinical manifestation except more foods,
More drink, diuresis, weight loss this " three-many-one-little " outside, also often there is " pine ", i.e. osteoporosis.According to statistics, it there are about half sugar friend
With osteoporosis.The cardinal symptom of diabetes is that blood sugar level is increased beyond renal glucose threshold, glucose in urine increase, cardiac muscle then occurs
Inflammation, peripheral neuritis, cataract, diabetic nephropathy and deteriorate into uremia.Because glucose in urine is high, with the hypertonic urine containing sugar
During discharge, substantial amounts of calcium, phosphorus are also drawn off, and reabsorption of the renal tubule to calcium phosphorus declines during hyperglycaemia, controls bad glycosuria
Patient nearly all has the negative balance of calcium phosphorus, and calcium discharge more than absorbing, and calcium level declines.The easy tetany of diabetes patient,
And this reason.In recent years research proposes new viewpoint to the diabetes cause of disease both at home and abroad, it is believed that is due to body calcium deficiency and causes
Metabolic disorder produces diabetes.Therefore, diabetes patient's supplement calcium, can pre- anti-osteoporosis generation；Meanwhile calcium ion
Pancreatic beta cell can be stimulated, promotes the generation of insulin, alleviates diabetic symptom.
According to incompletely statistics, there are more than 200 kinds of calcium-supplementing preparation, mostly traditional calcium, main bag on domestic market
Inorganic calcium, inorganic acid calcium and calcium of organic acid three major types are included, most common of which is calcium carbonate.Traditional calcium is in vivo in the form of an ion
Absorb, on the one hand calcium ion is easily combined with the material such as phytic acid, oxalic acid, aliphatic acid in meals and alkaline intestinal juice, after generating insoluble matter
It is a large amount of to be lost in；On the other hand influenceed by factors such as gastric acid secretion, VD supplements and calbindin deficiencies, considerable part can not be smooth
Absorbed through intestinal mucosa, so that what is be really efficiently absorbed and utilize is only seldom a part of, i.e., traditional calcium-enriching products are general
Store-through is absorbing the problem of difficult.
Amino acid chelated calcium is a kind of organic calcium with bioactivity, is easily absorbed by the human body.Prepare amino acid chela at present
Closing the method for calcium has the aminosal in aqueous phase to prepare amino acid chelated calcium, high-pressure fluid nanometer mill technology, Microwave Solid conjunction
Into amino technic acid, electrolysis prepare amino acid calcium, ion-exchange prepares amino acid calcium, rear three kinds of methods are because more or less
Ground has that operating process is complicated, equipment cost height is unsuitable for that radiation can be produced in popularization and application, operating process staff is made
Into unfavorable factors such as harm, it is impossible to be widely used in industrial production.Aminosal prepares amino acid chelated calcium in aqueous phase
Method, containing the high chicken feather of protein, fish-skin etc. amino acid source is obtained using enzymolysis, with inorganic calcium salt, shell calcium by handling
Solubility calcium is obtained, the mol ratio progress chelant for controlling amino acid source and calcium source is calculated, although this method chelating amino acids
The chelation percent of calcium can reach very high and be easily controlled, but the amino acid source that obtains respectively of the position from different animals and
Calcium source, even if huge legendary turtle synthesizing amino acid chelates calcium, can also there are mismatch and repellency with human body, potential safety hazard be present, make trouble
Person psychologically produces repulsion；And the setting with the animal bone of human body proximity by biochemical enzymolysis processing step is used, directly
Using animal bone as amino acid source and calcium source, operating process is simple, compatible in absorption of human body process as a kind of biological source
Property it is high, safe, people are more willing to receive such a safe, from the animal with human body proximity bone to pass through enzyme
The calcium source that solution obtains, but only drawback is that, it is low that amino acid with calcium complexing rate has height to have, and the stability of complexing is not also fixed, and inhales
Fruit of producing effects is uneven.In the market to digest calcium supplementing product of the bone calcium powder as calcium source, it is basic using being mixed with other raw materials
The mode of synthetic powder or tabletting piece agent, the first calcium absorptivity are not very good and stably, and second using animal bone as calcium
The calcium supplementing product in source, there is light or heavy stink smell, this allows the product for much needing the crowd to replenish the calcium to receive this mouthfeel.
Therefore need badly and develop the increase bone that a kind of suitable diabetes patient safe, in good taste, that calcium absorptivity is high takes
The product of density.
The content of the invention
It is an object of the invention to provide a kind of high-absorbility to digest increase diabetic bone of the bone calcium powder as calcium source
The composition of density.
It is a further object of the present invention to provide a kind of preparation method of described composition.
Technical scheme is as follows：
A kind of preparation method for the composition for increasing diabetic's bone density, comprises the following steps：
(1) weight share weighs：2~5 parts of oligoisomaltose, 10~20 parts of skimmed milk power, enzymolysis bone calcium powder 25~
35 parts, 15~20 parts of pumpkin powder, 3~7 parts of polydextrose, 0.6~0.8 part of vitamin D, 0.3~0.4 part of ferrous lactate；
(2) bone calcium powder, vitamin D, ferrous lactate will be digested to mix 20~40 minutes, and will add the oligomeric different malt of formula ratio
The mass percentage concentration that sugar, polydextrose are configured to is 50% aqueous solution, and fine pellet core is prepared using extrusion spheronization technique；
(3) by fine pellet core fluidized drying obtained by step (2)；
(4) it is enteric coated：Prepare coating solution concentration 22~26%, 40~45 DEG C of piece bed tempertaure, weightening 10~30%, enteric
Clothing is purchased from Fleder or BASF AG's water solubility coating agent, is discharged in simulate the gastric juice in 2h less than 5%, when PH is 6.8,
Discharged completely in 1h；
(5) the normal temperature purified water that pumpkin powder is added to 5~7 times of weight is stirred dissolving, after dissolving completely, adds slowly
Skimmed milk power, stir 30 minutes, continue to be sprayed onto on the micropill of step (4) enteric coated end, 3~5r/ of regulation coating pan rotating speed
Min, 40~45 DEG C of piece bed tempertaure, until having sprayed, coating weight gain 40-70%.
Preferably, the present composition is made up of the raw material components of following parts by weight：
3~4 parts of oligoisomaltose, 14~18 parts of skimmed milk power, 28~32 parts of enzymolysis bone calcium powder, pumpkin powder 16~18
Part, 4~6 parts of polydextrose, 0.65~0.75 part of vitamin D, 0.22~0.28 part of ferrous lactate.
It is furthermore preferred that the present composition is made up of the raw material components of following parts by weight：
3.7 parts of oligoisomaltose, 15 parts of skimmed milk power, 30 parts of enzymolysis bone calcium powder, 17.3 parts of pumpkin powder, polydextrose 5
Part, 0.5 part of vitamin D, 0.25 part of ferrous lactate.
Preferably, a diameter of 0.5~0.7mm of machine equipment extrusion cavities plate is extruded in step (2), rotating speed is 30~40r/
Min, round as a ball machine equipment air blast 10~20Hz of frequency, 1000~1500r/min of rotary speed.
It is further preferred that a diameter of 0.7mm, the rotating speed 40r/min of machine equipment extrusion cavities plate are extruded in step (2),
Round as a ball machine equipment air blast frequency 15Hz, rotary speed 1300r/min.
Preferably, temperature of charge is 50~60 DEG C in step (3), and drying time is 2~4h.
Preferably, temperature of charge is 55~60 DEG C in step (3), and drying time is 2~3h.
Preferably, coating solution concentration is 25% in step (4).
Enzymolysis bone calcium powder in the present invention is prepared using following methods：
(1) boiling：By processes such as the selected, cleanings of animal fresh bone, load in cooker, boiling 3~5 times, every time 1~2
Hour；
(2) grind：By the os purum after boiling, through coarse crushing, attritioning, roughly grind, be ground to below 260 mesh, aggregate and addition
The weight ratio of water is 1: 1~2；
(3) biochemical enzymolysis：Pulp after grinding is squeezed into biochemical cylinder, adds papain and bromelain weight ratio
1:2~5 compound protease, compound protease account for aggregate weight than 0.10~0.25%, and adding citric acid tune pH value to 5.5~
6.5,45~65 DEG C of 1~2h of stirring；Enzymolysis liquid adds alkali to neutralize, and inactivation, is used for next procedure, pulp is in the cylinder that sterilizes before dusting
Stop must not exceed 1 hour；
(4) drying is dusted：When inlet temperature reaches 180~185 DEG C, water storage tank valve is opened, when inlet temperature reaches
225 DEG C ± 10 DEG C, outlet temperature is when reaching 105 DEG C ± 5 DEG C, penstock is closed after stablizing 10 minutes, opens sterilizing cylinder tapping valve
Door, starts to dust.
Beneficial effects of the present invention：
The present invention have studied substantial amounts of documents and materials, include the mechanism of calcium uptake, generally believe traditional calcium (inorganic calcium, nothing
Machine acid calcium, calcium of organic acid) absorptivity it is poor, it is immediately used by the body with pattern of the calcium ion in intestinal absorption；And amino acid
Chelating calcium is easily absorbed by the body, and it is absorbed with amino acid chelated calcium molecular forms；And in technical scheme, use
Amino acid source and calcium source of the animal bone as amino acid chelated calcium, using boiling, grinding, biochemical enzymolysis, the dry work dusted
The obtained enzymolysis bone calcium powder of skill process is calcium source, and the chelation percent of the amino acid chelated calcium of the obtained enzymolysis bone calcium powder of this method is not
It is very high, and the stability of chelant has by force and has weak, how to improve the bioavilability of enzymolysis bone calcium powder used in our, it is existing
Do not recorded in technology, inventor is how to improve enzymolysis bone calcium powder in research as this problem of the mouthfeel of product of calcium source, meaning
Product one side mouthfeel is improved made from outer discovery technical scheme, and the absorptivity of another aspect calcium product obtains
Very big lifting is arrived, the significant effect for showing as the increase bone density of the micropill product obtained by technical solution of the present invention is better than
The product of other formulations of equal enzymolysis bone calcium powder dosage.
For technique effect caused by technical solution of the present invention, inventor speculates analysis, and it promotees calcium uptake mechanism：By enzyme
The center that capsule core is wrapped in micropill, outside parcel intestines are made in solution bone calcium powder, VD, ferrous lactate, oligoisomaltose, polydextrose
Molten clothing, then wrap up pumpkin powder and skimmed milk power and manufactured micropill, the soft sweet tea of entrance, the fishy smell of enzymolysis bone calcium powder is masked, is being suffered from
Person orally enters stomach, and the pumpkin powder and skimmed milk power of outer layer are diluted and digested by gastric juice, and enzymolysis bone calcium of the enteric coating in it
Powder, VD only just start to be disintegrated into duodenum and small intestine site, avoid the unstable amino acid chelated calcium of complexing and exist
Dissociated calcium ion in gastric juice and be largely lost in after generation insoluble matter is combined with the material such as phytic acid, oxalic acid, aliphatic acid in meals,
And the fine pellet core of the present invention is disintegrated after duodenum and small intestine is entered, calcium is with the molecular forms of amino acid chelated calcium, in VD
In the presence of promote calcium uptake, oligoisomaltose sugar also serves as prebiotics and further promotees calcium uptake, so as to show more
The effect of remarkable increase bone density；The pumpkin powder of addition has blood sugar reducing function, is taken more suitable for diabetic.
Test example
(1), efficacy test
1 data and method
1.1 general information：
Choose the diabetes B patient that is found in our unit 2015 annual health examination and with osteoporosis 120, man
Property 68, women 52,42~54 years old age, average age (46.52 ± 3.76) year, the course of disease 3 months~10 years, average course of disease
(4.35 ± 2.01) year, all patients meet the clinical criteria of diabetes B, and all cases are public using U.S. Lunar
The Dual-energy X-rays absorptionmetry measure bone density of department is below normal value, is bone loss or osteoporosis.120 patients are random
It is divided into experiment A groups, experiment B groups, tests C groups and to a group A groups, control B groups, control C groups, every group 20, six groups in age, property
Not, significant difference (P ＞ 0.05) is not present in the general information such as state of an illness, there is comparativity.
1.2 administrated method
To give the calculating of 800mg calcium daily, experiment A groups give the product of the embodiment of the present invention 1, each 6.6g, and daily 2
It is secondary；Experiment B groups give the product of the embodiment of the present invention 2, each 6.8g, 2 times a day；Experiment C groups give the embodiment of the present invention 3
Product, each 6.7g, 2 times a day；Control A groups give following product and (use the composition of embodiment 1：2 parts of oligoisomaltose, take off
10 parts of fat milk powder, 25 parts of enzymolysis bone calcium powder, 15 parts of pumpkin powder, 3 parts of polydextrose, 0.6 part of vitamin D, 0.3 part of ferrous lactate are mixed
Powder product made of conjunction), each 6.4g, 2 times a day；Control B groups give following product and (use the composition of embodiment 2：It is oligomeric different
5 parts of maltose, 20 parts of skimmed milk power, 35 parts of enzymolysis bone calcium powder, 20 parts of pumpkin powder, 7 parts of polydextrose, 0.8 part of vitamin D, breast
Sour ferrous 0.4 part adds water as tablet made from adhesive tabletting), each 6.8g, 2 times a day；Control C groups are given following
Product (uses the composition of embodiment 3：3 parts of oligoisomaltose, 14 parts of skimmed milk power, 28 parts of enzymolysis bone calcium powder, 16 parts of pumpkin powder,
4 parts of polydextrose, 0.65 part of vitamin D, 0.22 part of ferrous lactate directly mix capsule product made from filling), each 6.6g,
2 times a day.All cases are taken 3 months and treated.
1.3 observation items and measuring method
Bone density (BMD)：Respectively at before and after treatment using (the French Midlink companies life of dual energy X-ray absorptiometry measuring instrument
Production) measurement lumbar vertebrae normotopia (L1~L4) and femoral neck BMD value, unit use g/cm2。
It is horizontal to measure six groups of pretherapy and post-treatment empty stomaches of patient, 2h-plasma glucose level and glycated protein.
1.4 statistical procedures
Measurement data mean ± standard deviationRepresent, examined using t and carry out statistical analysis.
2 results
The pretherapy and post-treatment bone density value contrast of 2.1 6 groups of patients
The pretherapy and post-treatment BMD values of 1 six groups of table compare (g/cm2,)
Note：* compared with before treatment, P ＜ 0.05；* is compared with before treating, P ＜ 0.01
△ is compared with control group, P ＜ 0.05；△ △ are compared with control group, P ＜ 0.01
The pretherapy and post-treatment blood sugar level contrast of 2.2 6 groups of patients
The pretherapy and post-treatment blood sugar level contrast of 2 six groups of patients of table
Note：* compared with before treatment, P ＜ 0.05；* is compared with before treating, P ＜ 0.01
△ is compared with control group, P ＜ 0.05；△ △ are compared with control group, P ＜ 0.01
3 conclusions
Experiment A groups, experiment B groups, the experiment C groups of the present invention have the effect of highly significant, P ＜ in terms of bone density is increased
0.01；There is remarkable increasing compared with the enzymolysis bone calcium powder of control A groups, control B groups, control C groups is the non-micropill product of calcium source
Add the effect of bone density；The experiment A groups of the present invention, test B groups, experiment C groups and compare A groups, control B groups, control C groups in blood glucose
There are significant effect, P ＜ 0.05 in terms of regulation, experimental group is not distinguished significantly with control group in terms of blood glucose is adjusted, P ＞
0.05.All embodiments that inventor is write to the present invention are tested according to above-mentioned test method, and are obtained
Similar result of the test, it was demonstrated that the present composition has the effect of significant increase bone density, and can adjust blood well
Sugar, it is adapted to diabetes patient to use.
Embodiment
Embodiment 1
A kind of preparation method for the composition for increasing diabetic's bone density, comprises the following steps：
(1) weight share weighs：2 parts of oligoisomaltose, 10 parts of skimmed milk power, 25 parts of enzymolysis bone calcium powder, pumpkin powder
15 parts, 3 parts of polydextrose, 0.6 part of vitamin D, 0.3 part of ferrous lactate；
(2) enzymolysis bone calcium powder, vitamin D, ferrous lactate are mixed 20 minutes, add formula ratio oligoisomaltose,
The mass percentage concentration that polydextrose is configured to is 50% aqueous solution, and fine pellet core is prepared using extrusion spheronization technique, is extruded
Machine equipment extrudes the diameter 0.7mm, rotating speed 38r/min, round as a ball machine equipment air blast frequency 10Hz, rotary speed 1100r/ of orifice plate
min；
(3) by fine pellet core fluidized drying obtained by step (2), temperature of charge is 55 DEG C, drying time 3h；
(4) it is enteric coated：Coating solution concentration 22% is prepared, 40~45 DEG C of piece bed tempertaure, weightening 10%, enteric coating is purchased from not
Blue moral or BASF AG's water solubility coating agent, it is complete in 1h when PH is 6.8 less than 5% release in 2h in simulate the gastric juice
Release；
(5) the normal temperature purified water that pumpkin powder is added to 5 times of weight is stirred dissolving, after dissolving completely, adds slowly de-
Fat milk powder, stir 30 minutes, continue to be sprayed onto on the micropill of step (4) enteric coated end, adjust coating pan rotating speed 3r/min, piece
40~45 DEG C of bed tempertaure, until having sprayed, coating weight gain 70%.
The preparation method that bone calcium powder is digested in the present embodiment is as follows：
(1) boiling：By processes such as the selected, cleanings of animal fresh bone, load in cooker, boiling 3 times, 2 hours every time；
(2) grind：By the os purum after boiling, through coarse crushing, attritioning, roughly grind, be ground to below 260 mesh, aggregate and addition
The weight ratio of water is 1: 1；
(3) biochemical enzymolysis：Pulp after grinding is squeezed into biochemical cylinder, adds papain and bromelain weight ratio
1 ︰ 2 compound protease, compound protease account for aggregate weight than 0.10%, and adding citric acid adjusts pH value to 5.5,45 DEG C of stirring 1h；
Enzymolysis liquid adds alkali to neutralize, and inactivation, is used for next procedure, pulp is stopped in the cylinder that sterilizes and must not exceed 1 hour before dusting；
(4) drying is dusted：When inlet temperature reaches 180 DEG C, open water storage tank valve, when inlet temperature reach 225 DEG C,
When outlet temperature reaches 105 DEG C, penstock is closed after stablizing 10 minutes, sterilizing cylinder draining valve is opened, starts to dust.
Provide to detect by GB/T 5009.92, the calcium content of the enzymolysis bone calcium powder is 140g/kg.
Embodiment 2
A kind of preparation method for the composition for increasing diabetic's bone density, comprises the following steps：
(1) weight share weighs：5 parts of oligoisomaltose, 20 parts of skimmed milk power, 35 parts of enzymolysis bone calcium powder, pumpkin powder
20 parts, 7 parts of polydextrose, 0.8 part of vitamin D, 0.4 part of ferrous lactate；
(2) enzymolysis bone calcium powder, vitamin D, ferrous lactate are mixed 20 minutes, add formula ratio oligoisomaltose,
The mass percentage concentration that polydextrose is configured to is 50% aqueous solution, and fine pellet core is prepared using extrusion spheronization technique, is extruded
Machine equipment extrudes the diameter 0.6mm, rotating speed 34r/min, round as a ball machine equipment air blast frequency 15Hz, rotary speed 1200r/ of orifice plate
min；
(3) by fine pellet core fluidized drying obtained by step (2), temperature of charge is 60 DEG C, drying time 2h；
(4) it is enteric coated：Coating solution concentration 24% is prepared, 40~45 DEG C of piece bed tempertaure, weightening 20%, enteric coating is purchased from not
Blue moral or BASF AG's water solubility coating agent, it is complete in 1h when PH is 6.8 less than 5% release in 2h in simulate the gastric juice
Release；
(5) the normal temperature purified water that pumpkin powder is added to 7 times of weight is stirred dissolving, after dissolving completely, adds slowly de-
Fat milk powder, stir 30 minutes, continue to be sprayed onto on the micropill of step (4) enteric coated end, adjust coating pan rotating speed 3r/min, piece
40~45 DEG C of bed tempertaure, until having sprayed, coating weight gain 55%.
The preparation method that bone calcium powder is digested in the present embodiment is as follows：
(1) boiling：By processes such as the selected, cleanings of animal fresh bone, load in cooker, boiling 5 times, 1 hour every time；
(2) grind：By the os purum after boiling, through coarse crushing, attritioning, roughly grind, be ground to below 260 mesh, aggregate and addition
The weight ratio of water is 1: 2；
(3) biochemical enzymolysis：Pulp after grinding is squeezed into biochemical cylinder, adds papain and bromelain weight ratio
1 ︰ 5 compound protease, compound protease account for aggregate weight than 0.25%, and adding citric acid adjusts pH value to 6.5,65 DEG C of stirring 2h；
Enzymolysis liquid adds alkali to neutralize, and inactivation, is used for next procedure, pulp is stopped in the cylinder that sterilizes and must not exceed 1 hour before dusting；
(4) drying is dusted：When inlet temperature reaches 185 DEG C, open water storage tank valve, when inlet temperature reach 235 DEG C,
When outlet temperature reaches 110 DEG C, penstock is closed after stablizing 10 minutes, sterilizing cylinder draining valve is opened, starts to dust.
Provide to detect by GB/T 5009.92, the calcium content of the enzymolysis bone calcium powder is 150g/kg.
Embodiment 3
A kind of preparation method for the composition for increasing diabetic's bone density, comprises the following steps：
(1) weight share weighs：3 parts of oligoisomaltose, 14 parts of skimmed milk power, 28 parts of enzymolysis bone calcium powder, pumpkin powder
16 parts, 4 parts of polydextrose, 0.65 part of vitamin D, 0.22 part of ferrous lactate；
(2) enzymolysis bone calcium powder, vitamin D, ferrous lactate are mixed 40 minutes, add formula ratio oligoisomaltose,
The mass percentage concentration that polydextrose is configured to is 50% aqueous solution, and fine pellet core is prepared using extrusion spheronization technique, is extruded
Machine equipment extrudes the diameter 0.5mm, rotating speed 30r/min, round as a ball machine equipment air blast frequency 15Hz, rotary speed 1500r/ of orifice plate
min；
(3) by fine pellet core fluidized drying obtained by step (2), temperature of charge is 58 DEG C, drying time 2.5h；
(4) it is enteric coated：Coating solution concentration 25% is prepared, 40~45 DEG C of piece bed tempertaure, weightening 30%, enteric coating is purchased from not
Blue moral or BASF AG's water solubility coating agent, it is complete in 1h when PH is 6.8 less than 5% release in 2h in simulate the gastric juice
Release；
(5) the normal temperature purified water that pumpkin powder is added to 5 times of weight is stirred dissolving, after dissolving completely, adds slowly de-
Fat milk powder, stir 30 minutes, continue to be sprayed onto on the micropill of step (4) enteric coated end, adjust coating pan rotating speed 5r/min, piece
40~45 DEG C of bed tempertaure, until having sprayed, coating weight gain 45%.
The preparation method that bone calcium powder is digested in the present embodiment is as follows：
(1) boiling：By processes such as the selected, cleanings of animal fresh bone, load in cooker, boiling 4 times, 1.5 hours every time；
(2) grind：By the os purum after boiling, through coarse crushing, attritioning, roughly grind, be ground to below 260 mesh, aggregate and addition
The weight ratio of water is 1: 1.5；
(3) biochemical enzymolysis：Pulp after grinding is squeezed into biochemical cylinder, adds papain and bromelain weight ratio
1 ︰ 3 compound protease, compound protease account for aggregate weight than 0.15%, and adding citric acid adjusts pH value to 6.0,55 DEG C of stirrings
1.5h；Enzymolysis liquid adds alkali to neutralize, and inactivation, is used for next procedure, and pulp stops that to must not exceed 1 small in the cylinder that sterilizes before dusting
When；
(4) drying is dusted：When inlet temperature reaches 183 DEG C, open water storage tank valve, when inlet temperature reach 215 DEG C,
When outlet temperature reaches 100 DEG C, penstock is closed after stablizing 10 minutes, sterilizing cylinder draining valve is opened, starts to dust.
Provide to detect by GB/T 5009.92, the calcium content of the enzymolysis bone calcium powder is 143g/kg.
Embodiment 4
A kind of preparation method for the composition for increasing diabetic's bone density, comprises the following steps：
(1) weight share weighs：4 parts of oligoisomaltose, 18 parts of skimmed milk power, 35 parts of enzymolysis bone calcium powder, pumpkin powder
18 parts, 6 parts of polydextrose, 0.75 part of vitamin D, 0.28 part of ferrous lactate；
(2) enzymolysis bone calcium powder, vitamin D, ferrous lactate are mixed 20 minutes, add formula ratio oligoisomaltose,
The mass percentage concentration that polydextrose is configured to is 50% aqueous solution, and fine pellet core is prepared using extrusion spheronization technique, is extruded
Machine equipment extrudes the diameter 0.6mm, rotating speed 40r/min, round as a ball machine equipment air blast frequency 20Hz, rotary speed 1500r/ of orifice plate
min；
(3) by fine pellet core fluidized drying obtained by step (2), temperature of charge is 51 DEG C, drying time 4h；
(4) it is enteric coated：Coating solution concentration 23% is prepared, 40~45 DEG C of piece bed tempertaure, weightening 30%, enteric coating is purchased from not
Blue moral or BASF AG's water solubility coating agent, it is complete in 1h when PH is 6.8 less than 5% release in 2h in simulate the gastric juice
Release；
(5) the normal temperature purified water that pumpkin powder is added to 6 times of weight is stirred dissolving, after dissolving completely, adds slowly de-
Fat milk powder, stir 30 minutes, continue to be sprayed onto on the micropill of step (4) enteric coated end, adjust coating pan rotating speed 4r/min, piece
40~45 DEG C of bed tempertaure, until having sprayed, coating weight gain 40%.
The preparation method that bone calcium powder is digested in the present embodiment is as follows：
(1) boiling：By processes such as the selected, cleanings of animal fresh bone, load in cooker, boiling 3 times, 1 hour every time；
(2) grind：By the os purum after boiling, through coarse crushing, attritioning, roughly grind, be ground to below 260 mesh, aggregate and addition
The weight ratio of water is 1: 1；
(3) biochemical enzymolysis：Pulp after grinding is squeezed into biochemical cylinder, adds papain and bromelain weight ratio
1 ︰ 4 compound protease, compound protease account for aggregate weight than 0.20%, and adding citric acid adjusts pH value to 5.5,50 DEG C of stirring 1h；
Enzymolysis liquid adds alkali to neutralize, and inactivation, is used for next procedure, pulp is stopped in the cylinder that sterilizes and must not exceed 1 hour before dusting；
(4) drying is dusted：When inlet temperature reaches 181 DEG C, open water storage tank valve, when inlet temperature reach 220 DEG C,
When outlet temperature reaches 105 DEG C, penstock is closed after stablizing 10 minutes, sterilizing cylinder draining valve is opened, starts to dust.
Provide to detect by GB/T 5009.92, the calcium content of the enzymolysis bone calcium powder is 135g/kg.
Embodiment 5
A kind of preparation method for the composition for increasing diabetic's bone density, comprises the following steps：
(1) weight share weighs：3.7 parts of oligoisomaltose, 15 parts of skimmed milk power, 30 parts of enzymolysis bone calcium powder, pumpkin
17.3 parts of powder, 5 parts of polydextrose, 0.5 part of vitamin D, 0.25 part of ferrous lactate；
(2) enzymolysis bone calcium powder, vitamin D, ferrous lactate are mixed 20 minutes, add formula ratio oligoisomaltose,
The mass percentage concentration that polydextrose is configured to is 50% aqueous solution, and fine pellet core is prepared using extrusion spheronization technique, is extruded
Machine equipment extrudes the diameter 0.6mm, rotating speed 35r/min, round as a ball machine equipment air blast frequency 20Hz, rotary speed 1400r/ of orifice plate
min；
(3) by fine pellet core fluidized drying obtained by step (2), temperature of charge is 54 DEG C, drying time 3h；
(4) it is enteric coated：Coating solution concentration 24% is prepared, 40~45 DEG C of piece bed tempertaure, weightening 25%, enteric coating is purchased from not
Blue moral or BASF AG's water solubility coating agent, it is complete in 1h when PH is 6.8 less than 5% release in 2h in simulate the gastric juice
Release；
(5) the normal temperature purified water that pumpkin powder is added to 6 times of weight is stirred dissolving, after dissolving completely, adds slowly de-
Fat milk powder, stir 30 minutes, continue to be sprayed onto on the micropill of step (4) enteric coated end, adjust coating pan rotating speed 4r/min, piece
40~45 DEG C of bed tempertaure, until having sprayed, coating weight gain 53%.
The preparation method that bone calcium powder is digested in the present embodiment is as follows：
(1) boiling：By processes such as the selected, cleanings of animal fresh bone, load in cooker, boiling 5 times, 2 hours every time；
(2) grind：By the os purum after boiling, through coarse crushing, attritioning, roughly grind, be ground to below 260 mesh, aggregate and addition
The weight ratio of water is 1: 2；
(3) biochemical enzymolysis：Pulp after grinding is squeezed into biochemical cylinder, adds papain and bromelain weight ratio
1 ︰ 5 compound protease, compound protease account for aggregate weight than 0.25%, and adding citric acid adjusts pH value to 6.5,45 DEG C of stirring 2h；
Enzymolysis liquid adds alkali to neutralize, and inactivation, is used for next procedure, pulp is stopped in the cylinder that sterilizes and must not exceed 1 hour before dusting；
(4) drying is dusted：When inlet temperature reaches 185 DEG C, open water storage tank valve, when inlet temperature reach 230 DEG C,
When outlet temperature reaches 108 DEG C, penstock is closed after stablizing 10 minutes, sterilizing cylinder draining valve is opened, starts to dust.
Provide to detect by GB/T 5009.92, the calcium content of the enzymolysis bone calcium powder is 145g/kg.
Embodiment 6
A kind of preparation method for the composition for increasing diabetic's bone density, comprises the following steps：
(1) weight share weighs：3.7 parts of oligoisomaltose, 14 parts of skimmed milk power, 28 parts of enzymolysis bone calcium powder, pumpkin
16 parts of powder, 6 parts of polydextrose, 0.5 part of vitamin D, 0.25 part of ferrous lactate；
(2) enzymolysis bone calcium powder, vitamin D, ferrous lactate are mixed 20 minutes, add formula ratio oligoisomaltose,
The mass percentage concentration that polydextrose is configured to is 50% aqueous solution, and fine pellet core is prepared using extrusion spheronization technique, is extruded
Machine equipment extrudes the diameter 0.6mm, rotating speed 32r/min, round as a ball machine equipment air blast frequency 10Hz, rotary speed 1200r/ of orifice plate
min；
(3) by fine pellet core fluidized drying obtained by step (2), temperature of charge is 56 DEG C, drying time 3h；
(4) it is enteric coated：Coating solution concentration 26% is prepared, 40~45 DEG C of piece bed tempertaure, weightening 15%, enteric coating is purchased from not
Blue moral or BASF AG's water solubility coating agent, it is complete in 1h when PH is 6.8 less than 5% release in 2h in simulate the gastric juice
Release；
(5) the normal temperature purified water that pumpkin powder is added to 7 times of weight is stirred dissolving, after dissolving completely, adds slowly de-
Fat milk powder, stir 30 minutes, continue to be sprayed onto on the micropill of step (4) enteric coated end, adjust coating pan rotating speed 3r/min, piece
40~45 DEG C of bed tempertaure, until having sprayed, coating weight gain 70%.
The preparation method that bone calcium powder is digested in the present embodiment is as follows：
(1) boiling：By processes such as the selected, cleanings of animal fresh bone, load in cooker, boiling 3 times, 1.5 hours every time；
(2) grind：By the os purum after boiling, through coarse crushing, attritioning, roughly grind, be ground to below 260 mesh, aggregate and addition
The weight ratio of water is 1: 1.2；
(3) biochemical enzymolysis：Pulp after grinding is squeezed into biochemical cylinder, adds papain and bromelain weight ratio
1 ︰ 3 compound protease, compound protease account for aggregate weight than 0.18%, and adding citric acid adjusts pH value to 6.0,60 DEG C of stirring 1h；
Enzymolysis liquid adds alkali to neutralize, and inactivation, is used for next procedure, pulp is stopped in the cylinder that sterilizes and must not exceed 1 hour before dusting；
(4) drying is dusted：When inlet temperature reaches 184 DEG C, open water storage tank valve, when inlet temperature reach 226 DEG C,
When outlet temperature reaches 103 DEG C, penstock is closed after stablizing 10 minutes, sterilizing cylinder draining valve is opened, starts to dust.
Provide to detect by GB/T 5009.92, the calcium content of the enzymolysis bone calcium powder is 150g/kg.
Embodiment 7
A kind of preparation method for the composition for increasing diabetic's bone density, comprises the following steps：
(1) weight share weighs：4 parts of oligoisomaltose, 15 parts of skimmed milk power, 30 parts of enzymolysis bone calcium powder, pumpkin powder
18 parts, 4 parts of polydextrose, 0.75 part of vitamin D, 0.28 part of ferrous lactate；
(2) enzymolysis bone calcium powder, vitamin D, ferrous lactate are mixed 40 minutes, add formula ratio oligoisomaltose,
The mass percentage concentration that polydextrose is configured to is 50% aqueous solution, and fine pellet core is prepared using extrusion spheronization technique, is extruded
Machine equipment extrudes the diameter 0.5mm, rotating speed 40r/min, round as a ball machine equipment air blast frequency 15Hz, rotary speed 1400r/ of orifice plate
min；
(3) by fine pellet core fluidized drying obtained by step (2), temperature of charge is 60 DEG C, drying time 2h；
(4) it is enteric coated：Coating solution concentration 25% is prepared, 40~45 DEG C of piece bed tempertaure, weightening 28%, enteric coating is purchased from not
Blue moral or BASF AG's water solubility coating agent, it is complete in 1h when PH is 6.8 less than 5% release in 2h in simulate the gastric juice
Release；
(5) the normal temperature purified water that pumpkin powder is added to 6 times of weight is stirred dissolving, after dissolving completely, adds slowly de-
Fat milk powder, stir 30 minutes, continue to be sprayed onto on the micropill of step (4) enteric coated end, adjust coating pan rotating speed 4r/min, piece
40~45 DEG C of bed tempertaure, until having sprayed, coating weight gain 60%.
The preparation method that bone calcium powder is digested in the present embodiment is as follows：
(1) boiling：By processes such as the selected, cleanings of animal fresh bone, load in cooker, boiling 4 times, 2 hours every time；
(2) grind：By the os purum after boiling, through coarse crushing, attritioning, roughly grind, be ground to below 260 mesh, aggregate and addition
The weight ratio of water is 1: 1.8；
(3) biochemical enzymolysis：Pulp after grinding is squeezed into biochemical cylinder, adds papain and bromelain weight ratio
1 ︰ 4 compound protease, compound protease account for aggregate weight than 0.22%, and adding citric acid adjusts pH value to 5.5,58 DEG C of stirring 2h；
Enzymolysis liquid adds alkali to neutralize, and inactivation, is used for next procedure, pulp is stopped in the cylinder that sterilizes and must not exceed 1 hour before dusting；
(4) drying is dusted：When inlet temperature reaches 180 DEG C, open water storage tank valve, when inlet temperature reach 232 DEG C,
When outlet temperature reaches 108 DEG C, penstock is closed after stablizing 10 minutes, sterilizing cylinder draining valve is opened, starts to dust.
Provide to detect by GB/T 5009.92, the calcium content of the enzymolysis bone calcium powder is 138g/kg.
Embodiment 8
A kind of preparation method for the composition for increasing diabetic's bone density, comprises the following steps：
(1) weight share weighs：3.7 parts of oligoisomaltose, 18 parts of skimmed milk power, 28 parts of enzymolysis bone calcium powder, pumpkin
17.3 parts of powder, 5 parts of polydextrose, 0.75 part of vitamin D, 0.28 part of ferrous lactate；
(2) enzymolysis bone calcium powder, vitamin D, ferrous lactate are mixed 20 minutes, add formula ratio oligoisomaltose,
The mass percentage concentration that polydextrose is configured to is 50% aqueous solution, and fine pellet core is prepared using extrusion spheronization technique, is extruded
Machine equipment extrudes the diameter 0.5mm, rotating speed 38r/min, round as a ball machine equipment air blast frequency 20Hz, rotary speed 1300r/ of orifice plate
min；
(3) by fine pellet core fluidized drying obtained by step (2), temperature of charge is 55 DEG C, drying time 3h；
(4) it is enteric coated：Coating solution concentration 26% is prepared, 40~45 DEG C of piece bed tempertaure, weightening 30%, enteric coating is purchased from not
Blue moral or BASF AG's water solubility coating agent, it is complete in 1h when PH is 6.8 less than 5% release in 2h in simulate the gastric juice
Release；
(5) the normal temperature purified water that pumpkin powder is added to 6 times of weight is stirred dissolving, after dissolving completely, adds slowly de-
Fat milk powder, stir 30 minutes, continue to be sprayed onto on the micropill of step (4) enteric coated end, adjust coating pan rotating speed 5r/min, piece
40~45 DEG C of bed tempertaure, until having sprayed, coating weight gain 55%.
The preparation method that bone calcium powder is digested in the present embodiment is as follows：
(1) boiling：By processes such as the selected, cleanings of animal fresh bone, load in cooker, boiling 3 times, 2 hours every time；
(2) grind：By the os purum after boiling, through coarse crushing, attritioning, roughly grind, be ground to below 260 mesh, aggregate and addition
The weight ratio of water is 1: 1.5；
(3) biochemical enzymolysis：Pulp after grinding is squeezed into biochemical cylinder, adds papain and bromelain weight ratio
1 ︰ 4 compound protease, compound protease account for aggregate weight than 0.15%, and adding citric acid adjusts pH value to 6.0,55 DEG C of stirrings
1.5h；Enzymolysis liquid adds alkali to neutralize, and inactivation, is used for next procedure, and pulp stops that to must not exceed 1 small in the cylinder that sterilizes before dusting
When；
(4) drying is dusted：When inlet temperature reaches 185 DEG C, water storage tank valve is opened, when inlet temperature reaches 225 DEG C
DEG C, outlet temperature is when reaching 100 DEG C, penstock is closed after stablizing 10 minutes, sterilizing cylinder draining valve is opened, starts to dust.
Provide to detect by GB/T 5009.92, the calcium content of the enzymolysis bone calcium powder is 148g/kg.
Embodiment 9
A kind of preparation method for the composition for increasing diabetic's bone density, comprises the following steps：
(1) weight share weighs：4 parts of oligoisomaltose, 14 parts of skimmed milk power, 30 parts of enzymolysis bone calcium powder, pumpkin powder
20 parts, 7 parts of polydextrose, 0.5 part of vitamin D, 0.25 part of ferrous lactate；
(2) enzymolysis bone calcium powder, vitamin D, ferrous lactate are mixed 20 minutes, add formula ratio oligoisomaltose,
The mass percentage concentration that polydextrose is configured to is 50% aqueous solution, and fine pellet core is prepared using extrusion spheronization technique, is extruded
Machine equipment extrudes the diameter 0.7mm, rotating speed 30r/min, round as a ball machine equipment air blast frequency 10Hz, rotary speed 1100r/ of orifice plate
min；
(3) by fine pellet core fluidized drying obtained by step (2), temperature of charge is 57 DEG C, drying time 2.5h；
(4) it is enteric coated：Coating solution concentration 24% is prepared, 40~45 DEG C of piece bed tempertaure, weightening 25%, enteric coating is purchased from not
Blue moral or BASF AG's water solubility coating agent, it is complete in 1h when PH is 6.8 less than 5% release in 2h in simulate the gastric juice
Release；
(5) the normal temperature purified water that pumpkin powder is added to 6 times of weight is stirred dissolving, after dissolving completely, adds slowly de-
Fat milk powder, stir 30 minutes, continue to be sprayed onto on the micropill of step (4) enteric coated end, adjust coating pan rotating speed 3r/min, piece
40~45 DEG C of bed tempertaure, until having sprayed, coating weight gain 50%.
The preparation method that bone calcium powder is digested in the present embodiment is as follows：
(1) boiling：By processes such as the selected, cleanings of animal fresh bone, load in cooker, boiling 3 times, 1 hour every time；
(2) grind：By the os purum after boiling, through coarse crushing, attritioning, roughly grind, be ground to below 260 mesh, aggregate and addition
The weight ratio of water is 1: 2；
(3) biochemical enzymolysis：Pulp after grinding is squeezed into biochemical cylinder, adds papain and bromelain weight ratio
1 ︰ 2 compound protease, compound protease account for aggregate weight than 0.25%, and adding citric acid adjusts pH value to 6.0,48 DEG C of stirring 1h；
Enzymolysis liquid adds alkali to neutralize, and inactivation, is used for next procedure, pulp is stopped in the cylinder that sterilizes and must not exceed 1 hour before dusting；
(4) drying is dusted：When inlet temperature reaches 183 DEG C, open water storage tank valve, when inlet temperature reach 220 DEG C,
When outlet temperature reaches 105 DEG C, penstock is closed after stablizing 10 minutes, sterilizing cylinder draining valve is opened, starts to dust.
Provide to detect by GB/T 5009.92, the calcium content of the enzymolysis bone calcium powder is 160g/kg.
Embodiment 10
A kind of preparation method for the composition for increasing diabetic's bone density, comprises the following steps：
(1) weight share weighs：3.5 parts of oligoisomaltose, 16 parts of skimmed milk power, 29 parts of enzymolysis bone calcium powder, pumpkin
17 parts of powder, 5 parts of polydextrose, 0.65 part of vitamin D, 0.25 part of ferrous lactate；
(2) enzymolysis bone calcium powder, vitamin D, ferrous lactate are mixed 20 minutes, add formula ratio oligoisomaltose,
The mass percentage concentration that polydextrose is configured to is 50% aqueous solution, and fine pellet core is prepared using extrusion spheronization technique, is extruded
Machine equipment extrudes the diameter 0.6mm, rotating speed 35r/min, round as a ball machine equipment air blast frequency 20Hz, rotary speed 1500r/ of orifice plate
min；
(3) by fine pellet core fluidized drying obtained by step (2), temperature of charge is 54 DEG C, drying time 3h；
(4) it is enteric coated：Coating solution concentration 22% is prepared, 40~45 DEG C of piece bed tempertaure, weightening 23%, enteric coating is purchased from not
Blue moral or BASF AG's water solubility coating agent, it is complete in 1h when PH is 6.8 less than 5% release in 2h in simulate the gastric juice
Release；
(5) the normal temperature purified water that pumpkin powder is added to 6 times of weight is stirred dissolving, after dissolving completely, adds slowly de-
Fat milk powder, stir 30 minutes, continue to be sprayed onto on the micropill of step (4) enteric coated end, adjust coating pan rotating speed 4r/min, piece
40~45 DEG C of bed tempertaure, until having sprayed, coating weight gain 53%.
The preparation method that bone calcium powder is digested in the present embodiment is as follows：
(1) boiling：By processes such as the selected, cleanings of animal fresh bone, load in cooker, boiling 4 times, 1 hour every time；
(2) grind：By the os purum after boiling, through coarse crushing, attritioning, roughly grind, be ground to below 260 mesh, aggregate and addition
The weight ratio of water is 1: 1.5；
(3) biochemical enzymolysis：Pulp after grinding is squeezed into biochemical cylinder, adds papain and bromelain weight ratio
1 ︰ 3 compound protease, compound protease account for aggregate weight than 0.20%, and adding citric acid adjusts pH value to 6.5,65 DEG C of stirring 1h；
Enzymolysis liquid adds alkali to neutralize, and inactivation, is used for next procedure, pulp is stopped in the cylinder that sterilizes and must not exceed 1 hour before dusting；
(4) drying is dusted：When inlet temperature reaches 182 DEG C, open water storage tank valve, when inlet temperature reach 218 DEG C,
When outlet temperature reaches 100 DEG C, penstock is closed after stablizing 10 minutes, sterilizing cylinder draining valve is opened, starts to dust.
Provide to detect by GB/T 5009.92, the calcium content of the enzymolysis bone calcium powder is 155g/kg.
Embodiment 11
A kind of preparation method for the composition for increasing diabetic's bone density, comprises the following steps：
(1) weight share weighs：2.5 parts of oligoisomaltose, 18 parts of skimmed milk power, 29 parts of enzymolysis bone calcium powder, pumpkin
17.3 parts of powder, 5 parts of polydextrose, 0.5 part of vitamin D, 0.25 part of ferrous lactate；
(2) enzymolysis bone calcium powder, vitamin D, ferrous lactate are mixed 20 minutes, add formula ratio oligoisomaltose,
The mass percentage concentration that polydextrose is configured to is 50% aqueous solution, and fine pellet core is prepared using extrusion spheronization technique, is extruded
Machine equipment extrudes the diameter 0.5mm, rotating speed 30r/min, round as a ball machine equipment air blast frequency 10Hz, rotary speed 1000r/ of orifice plate
min；
(3) by fine pellet core fluidized drying obtained by step (2), temperature of charge is 50 DEG C, drying time 4h；
(4) it is enteric coated：Coating solution concentration 25% is prepared, 40~45 DEG C of piece bed tempertaure, weightening 26%, enteric coating is purchased from not
Blue moral or BASF AG's water solubility coating agent, it is complete in 1h when PH is 6.8 less than 5% release in 2h in simulate the gastric juice
Release；
(5) the normal temperature purified water that pumpkin powder is added to 6 times of weight is stirred dissolving, after dissolving completely, adds slowly de-
Fat milk powder, stir 30 minutes, continue to be sprayed onto on the micropill of step (4) enteric coated end, adjust coating pan rotating speed 3r/min, piece
40~45 DEG C of bed tempertaure, until having sprayed, coating weight gain 60%.
The preparation method that bone calcium powder is digested in the present embodiment is as follows：
(1) boiling：By processes such as the selected, cleanings of animal fresh bone, load in cooker, boiling 5 times, 1 hour every time；
(2) grind：By the os purum after boiling, through coarse crushing, attritioning, roughly grind, be ground to below 260 mesh, aggregate and addition
The weight ratio of water is 1: 1.7；
(3) biochemical enzymolysis：Pulp after grinding is squeezed into biochemical cylinder, adds papain and bromelain weight ratio
1 ︰ 4 compound protease, compound protease account for aggregate weight than 0.22%, and adding citric acid adjusts pH value to 5.5,50 DEG C of stirrings
1.5h；Enzymolysis liquid adds alkali to neutralize, and inactivation, is used for next procedure, and pulp stops that to must not exceed 1 small in the cylinder that sterilizes before dusting
When；
(4) drying is dusted：When inlet temperature reaches 180 DEG C, open water storage tank valve, when inlet temperature reach 225 DEG C,
When outlet temperature reaches 105 DEG C, penstock is closed after stablizing 10 minutes, sterilizing cylinder draining valve is opened, starts to dust.
Provide to detect by GB/T 5009.92, the calcium content of the enzymolysis bone calcium powder is 152g/kg.
Embodiment 12
A kind of preparation method for the composition for increasing diabetic's bone density, comprises the following steps：
(1) weight share weighs：4 parts of oligoisomaltose, 15 parts of skimmed milk power, 30 parts of enzymolysis bone calcium powder, pumpkin powder
18 parts, 5 parts of polydextrose, 0.5 part of vitamin D, 0.25 part of ferrous lactate；
(2) enzymolysis bone calcium powder, vitamin D, ferrous lactate are mixed 20 minutes, add formula ratio oligoisomaltose,
The mass percentage concentration that polydextrose is configured to is 50% aqueous solution, and fine pellet core is prepared using extrusion spheronization technique, is extruded
Machine equipment extrudes the diameter 0.7mm, rotating speed 40r/min, round as a ball machine equipment air blast frequency 15Hz, rotary speed 1300r/ of orifice plate
min；
(3) by fine pellet core fluidized drying obtained by step (2), temperature of charge is 55 DEG C, drying time 3h；
(4) it is enteric coated：Coating solution concentration 23% is prepared, 40~45 DEG C of piece bed tempertaure, weightening 20%, enteric coating is purchased from not
Blue moral or BASF AG's water solubility coating agent, it is complete in 1h when PH is 6.8 less than 5% release in 2h in simulate the gastric juice
Release；
(5) the normal temperature purified water that pumpkin powder is added to 5 times of weight is stirred dissolving, after dissolving completely, adds slowly de-
Fat milk powder, stir 30 minutes, continue to be sprayed onto on the micropill of step (4) enteric coated end, adjust coating pan rotating speed 4r/min, piece
40~45 DEG C of bed tempertaure, until having sprayed, coating weight gain 58%.
The preparation method that bone calcium powder is digested in the present embodiment is as follows：
(1) boiling：By processes such as the selected, cleanings of animal fresh bone, load in cooker, boiling 4 times, 1.5 hours every time；
(2) grind：By the os purum after boiling, through coarse crushing, attritioning, roughly grind, be ground to below 260 mesh, aggregate and addition
The weight ratio of water is 1: 1；
(3) biochemical enzymolysis：Pulp after grinding is squeezed into biochemical cylinder, adds papain and bromelain weight ratio
1 ︰ 5 compound protease, compound protease account for aggregate weight than 0.25%, and adding citric acid adjusts pH value to 6.0,60 DEG C of stirring 1h；
Enzymolysis liquid adds alkali to neutralize, and inactivation, is used for next procedure, pulp is stopped in the cylinder that sterilizes and must not exceed 1 hour before dusting；
(4) drying is dusted：When inlet temperature reaches 180 DEG C, open water storage tank valve, when inlet temperature reach 230 DEG C,
When outlet temperature reaches 110 DEG C, penstock is closed after stablizing 10 minutes, sterilizing cylinder draining valve is opened, starts to dust.
Provide to detect by GB/T 5009.92, the calcium content of the enzymolysis bone calcium powder is 155g/kg.
Embodiments of the invention are only the specific descriptions to technical scheme, are not the limitations to technical scheme, this area
Replacement or change that technical staff is done under conditions of the substantive content of the present invention is not changed each fall within the protection model of the present invention
Enclose.
Claims (10)
1. a kind of composition for increasing diabetic's bone density, is made up of the component of following parts by weight：Oligoisomaltose 2~
5 parts, 10~20 parts of skimmed milk power, 25~35 parts of enzymolysis bone calcium powder, 15~20 parts of pumpkin powder, 3~7 parts of polydextrose, vitamin
0.3~0.4 part of D0.6~0.8 part, ferrous lactate.
2. composition according to claim 1, it is characterised in that be made up of the component of following parts by weight：Oligomeric different malt
3~4 parts of sugar, 14~18 parts of skimmed milk power, 28~32 parts of enzymolysis bone calcium powder, 16~18 parts of pumpkin powder, 4~6 parts of polydextrose, dimension
Raw plain D0.65~0.75 part, 0.22~0.28 part of ferrous lactate.
3. composition according to claim 1, it is characterised in that be made up of the component of following parts by weight：Oligomeric different malt
3.7 parts of sugar, 15 parts of skimmed milk power, 30 parts of enzymolysis bone calcium powder, 17.3 parts of pumpkin powder, 5 parts of polydextrose, 0.5 part of vitamin D, breast
It is sour ferrous 0.25 part.
4. the preparation method of the composition described in a kind of claims 1 to 3 any claim, it is characterised in that including as follows
Step：
(1) enzymolysis bone calcium powder, vitamin D, ferrous lactate are mixed 20~40 minutes, add formula ratio oligoisomaltose,
The mass percentage concentration that polydextrose is configured to is 50% aqueous solution, and fine pellet core is prepared using extrusion spheronization technique；
(2) by fine pellet core fluidized drying obtained by step (1)；
(3) it is enteric coated：Prepare coating solution concentration 22~26%, 40~45 DEG C of piece bed tempertaure, weightening 10~30%, enteric coating purchase
From Fleder or BASF AG's water solubility coating agent, discharged in simulate the gastric juice in 2h less than 5%, when PH is 6.8, in 1h
Release completely；
(4) the normal temperature purified water that pumpkin powder is added to 5~7 times of weight is stirred dissolving, after dissolving completely, adds degreasing slowly
Milk powder, stir 30 minutes, continue to be sprayed onto on the micropill of step (3) enteric coated end, adjust coating pan 3~5r/min of rotating speed,
40~45 DEG C of piece bed tempertaure, until having sprayed, coating weight gain 40-70%.
5. the preparation method of composition according to claim 4, it is characterised in that enzymolysis bone calcium powder uses in step (1)
It is prepared by following methods：(1) boiling：By processes such as the selected, cleanings of animal fresh bone, load in cooker, boiling 3~5 times, every time
1~2 hour；(2) grind：By the os purum after boiling, through coarse crushing, attritioning, roughly grind, be ground to below 260 mesh, aggregate and addition
The weight ratio of water is 1: 1~2；(3) biochemical enzymolysis：Pulp after grinding is squeezed into biochemical cylinder, adds papain and pineapple
Protease weight is than 1:2~5 compound protease, compound protease account for aggregate weight than 0.10~0.25%, and adding citric acid is adjusted
PH value to 5.5~6.5,45~65 DEG C stirring 1~2h；Enzymolysis liquid adds alkali to neutralize, and inactivation, is used for next procedure, dust prebone
Slurry stops in the cylinder that sterilizes must not exceed 1 hour；(4) drying is dusted：When inlet temperature reaches 180~185 DEG C, water storage is opened
Tank valve, when inlet temperature reach 225 DEG C ± 10 DEG C, outlet temperature reach 105 DEG C ± 5 DEG C when, close water after stablizing 10 minutes
Valve, sterilizing cylinder draining valve is opened, starts to dust.
6. the preparation method of composition according to claim 4, it is characterised in that extrusion machine equipment extrusion in step (1)
A diameter of 0.5~0.7mm of orifice plate, rotating speed are 30~40r/min, round as a ball machine equipment air blast 10~20Hz of frequency, rotary speed
1000~1500r/min.
7. the preparation method of composition according to claim 6, it is characterised in that extrusion machine equipment extrusion in step (1)
A diameter of 0.7mm of orifice plate, rotating speed 40r/min, round as a ball machine equipment air blast frequency 15Hz, rotary speed 1300r/min.
8. the preparation method of composition according to claim 4, it is characterised in that in step (2) temperature of charge be 50~
60 DEG C, drying time is 2~4h.
9. the preparation method of composition according to claim 8, it is characterised in that in step (2) temperature of charge be 55~
60 DEG C, drying time is 2~3h.
10. the preparation method of composition according to claim 4, it is characterised in that coating solution concentration is in step (3)
25%.
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| CN201610860404.7A CN107412313A (en) | 2016-09-29 | 2016-09-29 | A kind of composition for increasing diabetic's bone density and preparation method thereof |
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| CN201610860404.7A CN107412313A (en) | 2016-09-29 | 2016-09-29 | A kind of composition for increasing diabetic's bone density and preparation method thereof |
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Citations (5)
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|---|---|---|---|---|
| CN1173366A (en) * | 1997-08-01 | 1998-02-18 | 天津天狮集团有限公司 | Hypoglycemic high calcium granule and its prodn. |
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| CN1623558A (en) * | 2003-12-01 | 2005-06-08 | 中国计量学院 | Pumpkin polysaccharide enteric coatel preparation |
| CN101244082A (en) * | 2008-03-27 | 2008-08-20 | 阿坝州九寨鼎盛科技有限责任公司 | Animal bone calcium and preparation thereof |
| CN101269211A (en) * | 2007-03-23 | 2008-09-24 | 天津天狮生物工程有限公司 | Shuangtang high calcium medicinal granule and preparation technique |
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|---|---|---|---|---|
| CN1173366A (en) * | 1997-08-01 | 1998-02-18 | 天津天狮集团有限公司 | Hypoglycemic high calcium granule and its prodn. |
| CN1408428A (en) * | 2002-08-30 | 2003-04-09 | 徐佳立 | Sugar cane free poly peptide calcium compensation powder and its producing method |
| CN1623558A (en) * | 2003-12-01 | 2005-06-08 | 中国计量学院 | Pumpkin polysaccharide enteric coatel preparation |
| CN101269211A (en) * | 2007-03-23 | 2008-09-24 | 天津天狮生物工程有限公司 | Shuangtang high calcium medicinal granule and preparation technique |
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Application publication date: 20171201 |