CN1623558A - Pumpkin polysaccharide enteric coatel preparation - Google Patents
Pumpkin polysaccharide enteric coatel preparation Download PDFInfo
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- CN1623558A CN1623558A CN 200310116847 CN200310116847A CN1623558A CN 1623558 A CN1623558 A CN 1623558A CN 200310116847 CN200310116847 CN 200310116847 CN 200310116847 A CN200310116847 A CN 200310116847A CN 1623558 A CN1623558 A CN 1623558A
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Abstract
An enteric medicine of cucurbic polyose for treating diabetes and hyperlepemia is prepared from cucurbic polyose, pregelatinized starch, superfine silica gel powder and calcium stearate through proportional mixing and loading in enteric capsules.
Description
Technical field
The present invention relates to a kind of product of preventing and treating diabetes.
Background technology
The nutritive value of Fructus Cucurbitae moschatae is very high, and Ancient Times in China just has pair record of Fructus Cucurbitae moschatae food therapy health effect.Record in the traditional Chinese medical science history records " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " Fructus Cucurbitae moschatae is warm in nature, sweet in the mouth is nontoxic, goes into spleen, stomach two warps, can moistening lung qi-benefitting, the evacuation of pus of reducing phlegm, anthelmintic detoxifcation, control diseases such as cough, asthma, lung abscess, constipation ", and think that Fructus Cucurbitae moschatae can " walk crosswise meridians, diuresis ".In Compendium of Material Medica, Li Mingzhen puts Fructus Cucurbitae moschatae and Ganoderma together, says that it has the effect of " invigorating middle warmer, tonifying liver gas, the beneficial motive, lung benefiting gas, beneficial vital essence ".All prolonged illness deficiency of vital energys, weakness of the spleen and stomach, disease see that shortness of breath and lassitude, lack of appetite abdominal distention, edema oliguria person should use.Result of study in recent years also shows, the nutritional labeling of Fructus Cucurbitae moschatae is comprehensive and unique, with the musky gourd is example, its nutritional labeling is moisture 90.24%, protein 0.65%, fat 0.13%, carbohydrate 6.08%, fiber 2.15%, ash 0.73%, also contains abundant carotene, V simultaneously
B, V
C, V
E, mineral, particularly rare amino acid citrulline content such as arginine, aspartic acid, adenine, pectin, mannitol, phylloerythrin, phylloxanthin and calcium, potassium, zinc, chromium reach 20.9mg/100g, pectin content accounts for the 7%-17% of dried pumpkin material.Medical clinical test shows that Fructus Cucurbitae moschatae has multiple food therapy health effect and medical value.As Fructus Cucurbitae moschatae is vitamin A high-quality, inexpensive fabulous source, vitamin A to vision protection, prevention ophthalmic, promote upgrowth and development of children, the oxidation of enhancing body antibiont etc. all to have important function.China some areas and crowd's vitamin A intake is insufficient, and the vitamin A precursor that Fructus Cucurbitae moschatae provides content height not only, and economic more than the animal food source.The health-care effect of Fructus Cucurbitae moschatae shows that also it can help to eliminate the inflammation of prostate and liver; Unnecessary cholesterol in the coalition, prevention and treatment atherosclerosis; Prevent gastrointestinal mucosa ulcer and promote healing; Promote bile secretion, strengthen gastrointestinal peristalsis, prevent constipation; Cure women's puerperal edema etc.
Although many alimentary health-care functions of Fructus Cucurbitae moschatae are known already, spread the widest, the sure antidiabetic effect that surely belongs to Fructus Cucurbitae moschatae of people the most.Existing at present report is made Fructus Cucurbitae moschatae dehydrate pulverizing Fructus Cucurbitae moschatae powder and is taken after mixing it with water, the may command diabetes, but this method consumption is big, edible trouble.In recent years, the research of Fructus Cucurbitae moschatae and application have obtained developing rapidly, successfully from Fructus Cucurbitae moschatae, filter out squash polyoses with remarkable blood sugar decreasing effect, but because squash polyoses belongs to polysaccharose substance, have viscosity, hygroscopicity, easily by acid and various enzymatic degradation and losing activity, directly edible blood sugar decreasing effect is very not remarkable at gastric.
Summary of the invention
The purpose of this invention is to provide a kind of have blood sugar lowering, glucose in urine, glycolated hemoglobin, the taking convenience of functions such as auxiliary treatment hyperlipidemia is beneficial to the squash polyoses enteric coated preparation of absorption of human body.
Squash polyoses enteric coated preparation of the present invention is the preparation of being packed into and being constituted behind enteric coated capsule or the parcel enteric coat by squash polyoses, pregelatinized Starch, micropowder silica gel, calcium stearate, the consumption of each main ingredient is respectively (by weight) squash polyoses 50～100, pregelatinized Starch 1～50, micropowder silica gel 0.15～3, calcium stearate 0.3～1.
Above-mentioned squash polyoses is that the order number is at 50～360 purpose off-white colors or little yellowy pressed powder, pregelatinized Starch, micropowder silica gel, calcium stearate are commercially available solid pharmaceutical preparation adjuvant, outward appearance is white or off-white powder, odorless, tasteless, 100 order percent of pass 100%.
Squash polyoses is self-control, preparation technology is: the Fructus Cucurbitae moschatae powder hot-water extraction, extract 50 ℃ of temperature, 4 hours extraction times, material-water ratio is 1: 8, extract after-filtration, filtrate is reclaimed, and filtering residue is collected filtrate with 95% ethanol lixiviate after 48 hours, merge two filtrates, obtain Fructus Cucurbitae moschatae extract just, add 95% ethanol precipitation Fructus Cucurbitae moschatae just extract, centrifuging and taking precipitate then, use dehydrated alcohol, petroleum ether is successively behind the washing precipitate, add 10% trichloroacetic acid of 1 times of volume, at room temperature stir rearmounted refrigerator overnight gently, centrifugal, abandon precipitation, pack into behind the concentrating under reduced pressure and dialysed against the current 1 day in the bag filter, distilled water dialysis 2 days, takes out dry must squash polyoses.
The processing technology of squash polyoses enteric coated preparation is as follows:
The squash polyoses enteric coated capsule: get squash polyoses, pregelatinized Starch and micropowder silica gel in proportion, sieve, mix homogeneously is packed into through the disinfectant enteric coated capsule, is product after the packing.
The squash polyoses enteric coatel tablets: get squash polyoses, pregelatinized Starch, micropowder silica gel and calcium stearate in proportion, sieve, mix homogeneously is granulated, tabletting, and coating, packing is product after the packing.
Squash polyoses enteric solubility microcapsule: the capsule core material squash polyoses is suspended in the enteric solubility capsule material, adds flocculating agent cohesion capsule, the sedimentation capsule solidifies capsule, and drying is product after the packing.
The squash polyoses enteric coated granule: get squash polyoses and the pregelatinized Starch back system soft material that is mixed that sieves in proportion, granulate, drying, granulate, coating is product after the packing.
Because pregelatinized Starch has good flowability, compressibility, lubricity and moisture-keeping function, have fabulous promotion disintegrate and dissolving out capability simultaneously, squash polyoses is mixed with pregelatinized Starch, can reduce the viscosity and the hygroscopicity of squash polyoses, increase volume, promote the dispersion and the stripping of active component.Micropowder silica gel has good flowability; the recess of rough surface is filled up on the surface that can stick to granule or powder; and granule separated; reduce intergranular friction, improve the flowability of material, can obviously improve the filling capacity of material in the capsule; it also is fluidizer commonly used in the tablet; hydrophilicity is strong, can quicken the disintegrate of tablet, helps the absorption of medicine.Calcium stearate has good tack, and is not easily separated with being evenly distributed after granule mixes, only with can demonstrating good lubrication on a small quantity, and unilateral smooth and beautiful appearance, be the lubricant of extensive use.
Enteric coating material commonly used mainly contains cellulose acetate phthalein ester (CAP), Lac, zein, acroleic acid resin, hypromellose phthalate ester (HPMCP), methacrylic acid copolymer etc., enteric agents also can adopt the gelatin spraying, and soon formaldehyde-acetone (1: 60) solution directly is sprayed on capsule and makes enteric coated capsule.
Zoopery shows, adopts the filling harmonization of the stomach to admix the mode that feedstuff is freely got food, because of polysaccharose substance is easily lost activity DeGrain by acid and various enzymatic degradation at gastric.And select oral positioning release medicine (being enteric coated capsule) mode for use, behind oral administration, medicine does not discharge and reaches the small intestinal spots localization and discharge at upper digestive tract, can make the polysaccharose substance that is subject to stomach acids destroy and pancreatin metabolism and loses therapeutical effect escape barrier, exempt from destruction, improve local drug concentration, improve bioavailability of medicament, improve curative effect, reduce oral consumption.
The specific embodiment
Embodiment 1:
The squash polyoses enteric coated capsule is packed into by squash polyoses, pregelatinized Starch, micropowder silica gel and is mixed with in the enteric coated capsule, squash polyoses 120g wherein, pregelatinized Starch 40g, micropowder silica gel 0.8g, make 1000 enteric coated capsulees, be that every squash polyoses enteric coated capsule contains squash polyoses 0.12g, pregelatinized Starch 0.04g, micropowder silica gel 0.8mg.
Embodiment 2:
The squash polyoses enteric coatel tablets are coated with enteric coating after by squash polyoses, pregelatinized Starch, micropowder silica gel, calcium stearate mixed pressuring plate and make, squash polyoses 100g wherein, pregelatinized Starch 50g, micropowder silica gel 0.9g, 0.6g in the calcium stearate makes 1000 enteric coated capsulees, be that every squash polyoses enteric coated capsule contains squash polyoses 0.12g, pregelatinized Starch 0.04g, micropowder silica gel 0.8mg, calcium stearate 0.6mg.
Embodiment 3:
Squash polyoses enteric solubility microcapsule is suspended in the Lac by squash polyoses, and the sodium sulfate with 60% makes capsule cohesion, and the formaldehyde of reuse 37% solidifies capsule, after lyophilization, make, and squash polyoses 100g wherein, Lac 100ml makes dried microcapsule.
Embodiment 4:
The squash polyoses enteric coated granule mixes the back by squash polyoses, pregelatinized Starch and crosses 100 mesh sieves, and the pregelatinized Starch that adds with dissolved in distilled water mixes, and granulates behind the mix homogeneously, 60～65 ℃ of dryings, granulate is coated with enteric coating, classification promptly, squash polyoses 100g wherein, pregelatinized Starch 100g.
Claims (7)
1, a kind of squash polyoses enteric coated preparation comprises (by weight) squash polyoses 50～100, pregelatinized Starch 1～50, micropowder silica gel 0.15～3, calcium stearate 0.3～1.
2, squash polyoses enteric coated preparation according to claim 1 is characterized in that: said squash polyoses is that the order number is at 50～360 purpose off-white colors or little yellowy pressed powder.
3, squash polyoses enteric coated preparation according to claim 1 and 2, wherein used enteric coating material are cellulose acetate phthalein ester, Lac, zein, acroleic acid resin, hypromellose phthalate ester or methacrylic acid copolymer.
4, according to any one squash polyoses enteric coated preparation of claim 1 to 3, it is characterized in that it is squash polyoses enteric coated capsule, squash polyoses enteric coatel tablets, squash polyoses enteric solubility microcapsule or squash polyoses enteric coated granule form.
5, a kind of preparation method of squash polyoses enteric coated preparation, comprise squash polyoses, pregelatinized Starch, micropowder silica gel and calcium stearate are packed in enteric coated capsule or the parcel enteric coat, wherein the consumption of squash polyoses, pregelatinized Starch, micropowder silica gel, calcium stearate is respectively (by weight) squash polyoses 50～100, pregelatinized Starch 1～50, micropowder silica gel 0.15～3, calcium stearate 0.3～1.
6, preparation method according to claim 4 is characterized in that said squash polyoses is that the order number is at 50～360 purpose off-white colors or little yellowy pressed powder.
7, preparation method according to claim 4 is characterized in that used enteric coating material is cellulose acetate phthalein ester, Lac, zein, acroleic acid resin, hypromellose phthalate ester (HPMCP) or methacrylic acid copolymer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2003101168478A CN100569242C (en) | 2003-12-01 | 2003-12-01 | The squash polyoses enteric coated preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2003101168478A CN100569242C (en) | 2003-12-01 | 2003-12-01 | The squash polyoses enteric coated preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1623558A true CN1623558A (en) | 2005-06-08 |
| CN100569242C CN100569242C (en) | 2009-12-16 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2003101168478A Expired - Fee Related CN100569242C (en) | 2003-12-01 | 2003-12-01 | The squash polyoses enteric coated preparation |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103054829A (en) * | 2012-11-29 | 2013-04-24 | 四川健能制药有限公司 | Doxofylline capsule and preparation method thereof |
| CN106214623A (en) * | 2016-03-08 | 2016-12-14 | 兰州理工大学 | There is the preparation method of the squash polyoses composite aquogel of blood sugar reducing function |
| CN107412313A (en) * | 2016-09-29 | 2017-12-01 | 天津天狮生物发展有限公司 | A kind of composition for increasing diabetic's bone density and preparation method thereof |
-
2003
- 2003-12-01 CN CNB2003101168478A patent/CN100569242C/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103054829A (en) * | 2012-11-29 | 2013-04-24 | 四川健能制药有限公司 | Doxofylline capsule and preparation method thereof |
| CN106214623A (en) * | 2016-03-08 | 2016-12-14 | 兰州理工大学 | There is the preparation method of the squash polyoses composite aquogel of blood sugar reducing function |
| CN106214623B (en) * | 2016-03-08 | 2019-07-23 | 兰州理工大学 | The preparation method of squash polyoses composite hydrogel with blood sugar reducing function |
| CN107412313A (en) * | 2016-09-29 | 2017-12-01 | 天津天狮生物发展有限公司 | A kind of composition for increasing diabetic's bone density and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN100569242C (en) | 2009-12-16 |
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