CN107406881B - 用于指导癌症治疗的内容相关的诊断测试 - Google Patents
用于指导癌症治疗的内容相关的诊断测试 Download PDFInfo
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- CN107406881B CN107406881B CN201680011405.2A CN201680011405A CN107406881B CN 107406881 B CN107406881 B CN 107406881B CN 201680011405 A CN201680011405 A CN 201680011405A CN 107406881 B CN107406881 B CN 107406881B
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
- G16B40/10—Signal processing, e.g. from mass spectrometry [MS] or from PCR
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
- G16B40/20—Supervised data analysis
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/50—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
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- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Medical Informatics (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Data Mining & Analysis (AREA)
- Spectroscopy & Molecular Physics (AREA)
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- Genetics & Genomics (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
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- Evolutionary Biology (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562102499P | 2015-01-12 | 2015-01-12 | |
| US62/102,499 | 2015-01-12 | ||
| PCT/US2016/013003 WO2016115105A1 (en) | 2015-01-12 | 2016-01-12 | Context dependent diagnostics test for guiding cancer treatment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107406881A CN107406881A (zh) | 2017-11-28 |
| CN107406881B true CN107406881B (zh) | 2021-05-25 |
Family
ID=56406281
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680011405.2A Expired - Fee Related CN107406881B (zh) | 2015-01-12 | 2016-01-12 | 用于指导癌症治疗的内容相关的诊断测试 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US10793915B2 (https=) |
| EP (1) | EP3245301B1 (https=) |
| JP (1) | JP6774951B2 (https=) |
| KR (1) | KR20170126867A (https=) |
| CN (1) | CN107406881B (https=) |
| AU (1) | AU2016206882B2 (https=) |
| CA (1) | CA2974240A1 (https=) |
| HK (1) | HK1247250A1 (https=) |
| WO (1) | WO2016115105A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HK1251655A1 (zh) | 2015-04-20 | 2019-02-01 | Tolero Pharmaceuticals, Inc. | 通过线粒体分析预测对阿伏西地的应答 |
| KR102608921B1 (ko) | 2015-05-18 | 2023-12-01 | 스미토모 파마 온콜로지, 인크. | 생체 이용률이 증가된 알보시딥 프로드러그 |
| JP7083497B2 (ja) | 2015-08-03 | 2022-06-13 | スミトモ ファーマ オンコロジー, インコーポレイテッド | がんの処置のための併用療法 |
| WO2018094275A1 (en) | 2016-11-18 | 2018-05-24 | Tolero Pharmaceuticals, Inc. | Alvocidib prodrugs and their use as protein kinase inhibitors |
| AU2017379847B2 (en) | 2016-12-19 | 2022-05-26 | Sumitomo Pharma Oncology, Inc. | Profiling peptides and methods for sensitivity profiling |
| EP3385715A1 (en) | 2017-04-04 | 2018-10-10 | Medizinische Hochschule Hannover | Analytical process for predicting the therapeutic effect of bh3 mimetics |
| JP7196160B2 (ja) | 2017-09-12 | 2022-12-26 | スミトモ ファーマ オンコロジー, インコーポレイテッド | Mcl-1阻害剤アルボシジブを用いた、bcl-2阻害剤に対して非感受性である癌の治療レジメン |
| CN108070562A (zh) * | 2018-02-03 | 2018-05-25 | 金华市中心医院 | 一种“双打击”弥漫大b细胞淋巴瘤细胞系制备方法 |
| PT110722B (pt) * | 2018-05-03 | 2021-08-17 | Instituto De Patologia E Imunologia Molecular Da Univ Do Porto Ipatimup | Uso de anticorpos para o antigénio thomsen-friedenreich num método e estojo para avaliação de instabilidade de microsatelites |
| US11034710B2 (en) | 2018-12-04 | 2021-06-15 | Sumitomo Dainippon Pharma Oncology, Inc. | CDK9 inhibitors and polymorphs thereof for use as agents for treatment of cancer |
| WO2020191326A1 (en) | 2019-03-20 | 2020-09-24 | Sumitomo Dainippon Pharma Oncology, Inc. | Treatment of acute myeloid leukemia (aml) with venetoclax failure |
| US20230187075A1 (en) * | 2021-12-14 | 2023-06-15 | Shuhua Zheng | Method and system for artificial intelligence based risk stratification for glioma |
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| US5622852A (en) | 1994-10-31 | 1997-04-22 | Washington University | Bcl-x/Bcl-2 associated cell death regulator |
| GB9422836D0 (en) * | 1994-11-11 | 1995-01-04 | Wainscoat James | Monitoring malignant disease |
| WO1998009643A1 (en) | 1996-09-09 | 1998-03-12 | Washington University | Modulation of apoptosis by serine phosphorylation of blc-xl/blc-2 associated cell death regulator |
| US5955593A (en) | 1996-09-09 | 1999-09-21 | Washington University | BH3 interacting domain death agonist |
| US5856445A (en) | 1996-10-18 | 1999-01-05 | Washington University | Serine substituted mutants of BCL-XL /BCL-2 associated cell death regulator |
| US5981201A (en) | 1997-01-08 | 1999-11-09 | Beth Israel Deaconess Medical Center | Methods of detection and treatment of breast cancer |
| GB9704444D0 (en) | 1997-03-04 | 1997-04-23 | Isis Innovation | Non-invasive prenatal diagnosis |
| EP1015578A4 (en) | 1997-09-17 | 2004-12-01 | Walker And Eliza Hall Inst Of | THERAPEUTIC MOLECULES |
| WO1999016787A1 (en) | 1997-09-26 | 1999-04-08 | Washington University | Cell death agonists |
| US6165732A (en) | 1997-10-14 | 2000-12-26 | Washington University | Method for identifying apoptosis modulating compounds |
| US7026456B1 (en) | 1998-01-23 | 2006-04-11 | Hoffman-La Roche, Inc. | Antibodies against human IL-12 |
| EP1080233A4 (en) | 1998-05-18 | 2003-02-05 | Apoptosis Technology Inc | COMPOUNDS, SCREENING METHODS, AND USES USING ANTI-APOPTIC GENES AND GENE PRODUCTS |
| EP1104460A1 (en) | 1998-08-19 | 2001-06-06 | Washington University | Modulation of apoptosis with bid |
| US6326354B1 (en) | 1998-08-19 | 2001-12-04 | Washington University | Modulation of apoptosis with bid |
| AU2001271426A1 (en) | 2000-07-17 | 2002-01-30 | Washington University | Modulation of apoptosis |
| US20020177692A1 (en) | 2001-04-16 | 2002-11-28 | Myriad Genetics, Incorporated | BCL-XL-interacting protein and use thereof |
| EP1436406A4 (en) | 2001-09-24 | 2004-10-13 | Blood Ct Res Foundation | METHOD FOR MODULATING OR EXAMINING THE KU70 MIRROR IN CELLS |
| WO2003057158A2 (en) | 2001-12-31 | 2003-07-17 | Dana-Farber Cancer Institute, Inc. | Method of treating apoptosis and compositions thereof |
| US20040171809A1 (en) | 2002-09-09 | 2004-09-02 | Korsmeyer Stanley J. | BH3 peptides and method of use thereof |
| ATE474922T1 (de) | 2002-12-26 | 2010-08-15 | Zakrytoe Aktsionernoe Obschest | Fluoreszenzproteine aus copepoda-spezies und verfahren zur verwendung davon |
| EP1613205B1 (en) | 2003-04-01 | 2013-04-24 | Monogram BioSciences, Inc. | Erbb surface receptor complexes as biomarkers |
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| CN1302004C (zh) | 2003-08-22 | 2007-02-28 | 浙江海正药业股份有限公司 | 一种阿糖胞苷的制备方法 |
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| NZ596468A (en) | 2009-05-14 | 2013-11-29 | Nestec Sa | Biomarkers for determining sensitivity of breast cancer cells to her2-targeted therapy |
| US20130011393A1 (en) | 2010-01-12 | 2013-01-10 | Johnathan Mark Lancaster | Bad pathway gene signature |
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| US9012215B2 (en) * | 2011-09-22 | 2015-04-21 | The Johns Hopkins University | Methods for identifying leukemia stem cells and distinguishing them from normal hematopietic stem cells in patients with acute myeloid leukemia: uses in diagnosis, treatment, and research |
| WO2013138702A2 (en) | 2012-03-15 | 2013-09-19 | Bristol-Myers Squibb Company | Methods for predicting gastrointestinal immune-related adverse events (gi-irae) in patients treated with modulation of the co-stimulatory pathway |
| US20150301053A1 (en) | 2012-05-10 | 2015-10-22 | Eutropics Pharmaceuticals, Inc. | Surrogate functional diagnostics test for cancer |
| JP6352924B2 (ja) | 2012-09-19 | 2018-07-04 | ダナ−ファーバー キャンサー インスティテュート, インコーポレイテッド | ダイナミックbh3プロファイリング |
| US20160038503A1 (en) * | 2012-11-21 | 2016-02-11 | David Richard | Methods and compositions useful for treating diseases involving bcl-2 family proteins with isoquinoline and quinoline derivatives |
| AU2014323526B2 (en) | 2013-09-19 | 2020-07-23 | Dana-Farber Cancer Institute, Inc. | Methods of BH3 profiling |
| JP6538044B2 (ja) * | 2013-10-30 | 2019-07-03 | ユートロピクス ファーマシューティカルズ, インコーポレイテッド | 化学療法感受性および化学毒性を判定する方法 |
| EP3288964B1 (en) | 2015-04-27 | 2024-02-21 | Dana-Farber Cancer Institute, Inc. | High throughput bh3 profiling: a rapid and scalable technology to bh3 profile on low numbers of cells |
-
2016
- 2016-01-12 US US15/542,520 patent/US10793915B2/en not_active Expired - Fee Related
- 2016-01-12 AU AU2016206882A patent/AU2016206882B2/en not_active Ceased
- 2016-01-12 CA CA2974240A patent/CA2974240A1/en active Pending
- 2016-01-12 HK HK18106406.5A patent/HK1247250A1/zh unknown
- 2016-01-12 WO PCT/US2016/013003 patent/WO2016115105A1/en not_active Ceased
- 2016-01-12 CN CN201680011405.2A patent/CN107406881B/zh not_active Expired - Fee Related
- 2016-01-12 KR KR1020177022475A patent/KR20170126867A/ko not_active Ceased
- 2016-01-12 EP EP16737714.2A patent/EP3245301B1/en active Active
- 2016-01-12 JP JP2017536828A patent/JP6774951B2/ja not_active Expired - Fee Related
-
2020
- 2020-06-25 US US16/912,097 patent/US20200392585A1/en not_active Abandoned
Non-Patent Citations (2)
| Title |
|---|
| MCL-1 dependence predicts response to vorinostat and gemtuzumab ozogamicin in acute myeloid leukemia;WILLIAM E. PIERCEALL等;《LEUKEMIA RESEARCH》;20140228;第38卷(第5期);第564-568页 * |
| relative mitochondrial priming of myeloblasts and normal HSCs determines chemotherapeutic success in AML;VO THANH-TRANG等;《CELL》;20111011;第151卷(第2期);第344-355页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2018503092A (ja) | 2018-02-01 |
| JP6774951B2 (ja) | 2020-11-04 |
| HK1247250A1 (zh) | 2018-09-21 |
| US20200392585A1 (en) | 2020-12-17 |
| AU2016206882A1 (en) | 2017-07-27 |
| WO2016115105A1 (en) | 2016-07-21 |
| US10793915B2 (en) | 2020-10-06 |
| KR20170126867A (ko) | 2017-11-20 |
| EP3245301A1 (en) | 2017-11-22 |
| CN107406881A (zh) | 2017-11-28 |
| AU2016206882B2 (en) | 2022-03-10 |
| EP3245301B1 (en) | 2020-11-11 |
| EP3245301A4 (en) | 2018-11-21 |
| CA2974240A1 (en) | 2016-07-21 |
| US20180340229A1 (en) | 2018-11-29 |
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Granted publication date: 20210525 |