CN107397849A - 一种治疗风赤疮痍的中药组合物 - Google Patents

一种治疗风赤疮痍的中药组合物 Download PDF

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CN107397849A
CN107397849A CN201710715948.9A CN201710715948A CN107397849A CN 107397849 A CN107397849 A CN 107397849A CN 201710715948 A CN201710715948 A CN 201710715948A CN 107397849 A CN107397849 A CN 107397849A
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姚洪超
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Abstract

本发明涉及一种治疗风赤疮痍的中药组合物，其中药原料及重量份配比为：天青地白10‑30份、小飞扬草5‑25份、毛罗勒5‑25份、凌霄花12份、虎耳草5‑25份、匍伏堇5‑25份、紫草5‑20份、三颗针5‑25份、莲蓬草5‑25份、半边旗5‑25份、地柑5‑20份、白花猪母菜5‑25份、鸭儿芹5‑25份、水蓼5‑20份、四季青5‑25份、天葵子5‑20份、老虎泡5‑25份、刺郎果5‑25份、楼梯草5‑20份、铜锤玉带草5‑25份、甘草5‑15份。本发明的中药组合物配伍科学、组方精炼，具有疏风清热、利湿解毒、清心泻火、祛风止痒、消炎止痛、消肿排脓、生肌敛疮的功效，其治疗风赤疮痍疗效显著，作用可靠。

Description

一种治疗风赤疮痍的中药组合物
技术领域
本发明属于中药技术领域，具体涉及一种治疗风赤疮痍的中药组合物。
背景技术
风赤疮痍是指以胞睑皮肤红赤肿痛，起水疱，溃后糜烂胶粘，结痂脱落遗留瘢痕为主要表现的眼病。相当于某些眼睑皮肤炎症。其特点为：1.多单眼发病，起病急，发展快。2.局部刺痒或灼痛，或有畏光流泪，初起或有发热、头痛等症。重症、变症可见高热头痛、恶心呕吐。3.眼睑皮肤红赤、肿胀，并见水泡或丘疹，继则成脓疱，破溃出脓血，或溃烂渗液。疱疹此起彼伏，秽汁痂皮结聚。重者耳前可有核肿痛。目前，治疗风赤疮痍多采用口服牛黄解毒丸、穿心莲片或用清开灵注射液、双黄连静脉滴注，虽有疗效，但存在疗程长及易复发的不足。
发明内容
本发明的目的是根据中医对风赤疮痍一症的认识机理，提供一种配伍科学、组方简便、成本低、疗效显著、无副作用的治疗风赤疮痍的中药组合物。
为了实现上述目的，本发明提供的技术方案是：一种治疗风赤疮痍的中药组合物，其特征在于：其中药原料及重量份配比为：天青地白10-30份、小飞扬草5-25份、毛罗勒5-25份、凌霄花5-20份、虎耳草5-25份、匍伏堇5-25份、紫草5-20份、三颗针5-25份、莲蓬草5-25份、半边旗5-25份、地柑5-20份、白花猪母菜5-25份、鸭儿芹5-25份、水蓼5-20份、四季青5-25份、天葵子5-20份、老虎泡5-25份、刺郎果5-25份、楼梯草5-20份、铜锤玉带草5-25份、甘草5-15份。
本发明的优选技术方案是：一种治疗风赤疮痍的中药组合物，其特征在于：其中药原料及重量份配比为：天青地白20份、小飞扬草15份、毛罗勒15份、凌霄花12份、虎耳草15份、匍伏堇15份、紫草10份、三颗针15份、莲蓬草15份、半边旗15份、地柑10份、白花猪母菜15份、鸭儿芹15份、水蓼12份、四季青15份、天葵子10份、老虎泡15份、刺郎果15份、楼梯草10份、铜锤玉带草15份、甘草10份。
祖国医学认为风赤疮痍多因脾胃湿热蕴积，外受风热毒邪，内夹心火，上攻胞睑所致。故治疗时应以疏风清热、利湿解毒、清心泻火、祛风止痒、消炎止痛、消肿排脓、生肌敛疮为主。本发明中药组合物中：天青地白疏风清热、利湿解毒，地柑清心泻火、凉血止血，此二味药合用具有疏风清热、利湿解毒、清心泻火之功，共为君药。虎耳草疏风清热、凉血解毒，半边旗清热利湿、凉血止血、解毒消肿，小飞扬草清热利湿、消肿解毒，毛罗勒健脾化湿，祛风活血，铜锤玉带草祛风除湿、活血解毒，三颗针清热燥湿、泻火解毒，凌霄花清热凉血、化瘀散结、祛风止痒，刺郎果清热解毒、消炎止痛，此八味药共为臣药。一方面辅助君药疏风清热、利湿解毒泻火；另一方面作为臣药，具有祛风止痒、消炎止痛的功效。水蓼行滞化湿、散瘀止血、祛风止痒、解毒，鸭儿芹消炎解毒、活血消肿，楼梯草清热解毒、祛风除湿、利水消肿、活血止痛，紫草清热凉血、活血化瘀、解毒透疹，莲蓬草清热解毒、凉血止血、消肿散结，白花猪母菜清热凉血、解毒消肿，天葵子清热解毒、消肿散结、利水通淋，匍伏堇清热解毒、消肿排脓，四季青清热解毒、生肌敛疮、活血止血，老虎泡凉血止血、祛风除湿、解毒疗疮，此十味药共为佐药，一方面辅佐臣药祛风止痒、消炎止痛，另一方面作为佐药，具有消肿排脓、生肌敛疮的功效。甘草补脾益气、调和诸药，为使药。此方诸药合用，君臣协力，臣使共辅，具有疏风清热、利湿解毒、清心泻火、祛风止痒、消炎止痛、消肿排脓、生肌敛疮的功效，对风赤疮痍的治疗达到标本兼治。
本发明组合物的组分均采用天然的中药原料，其配制简便、药源广、成本低。本发明遵循中医的处方用药原则，各种组分药物采用水煎服用。经临床应用验证和中药品不良反应（ADR）安全性评价，其疗效显著，安全可靠，药性平和，未出现毒副作用，未出现毒副作用，有效率达97.5%，治愈率86.25%。
具体实施方式
下面结合实施例对本发明作进一步说明。
实施例1
一种治疗风赤疮痍的中药组合物，其中药原料及重量配比为：天青地白20g、小飞扬草15g、毛罗勒15g、凌霄花12g、虎耳草15g、匍伏堇15g、紫草10g、三颗针15g、莲蓬草15g、半边旗15g、地柑10g、白花猪母菜15g、鸭儿芹15g、水蓼12g、四季青15g、天葵子10g、老虎泡15g、刺郎果15g、楼梯草10g、铜锤玉带草15g、甘草10g。
实施例2
一种治疗风赤疮痍的中药组合物，其中药原料及重量配比为：天青地白15g、小飞扬草25g、毛罗勒10g、凌霄花20g、虎耳草5g、匍伏堇25g、紫草12g、三颗针20g、莲蓬草5g、半边旗25g、地柑12g、白花猪母菜20g、鸭儿芹5g、水蓼15g、四季青10g、天葵子20g、老虎泡5g、刺郎果25g、楼梯草12g、铜锤玉带草20g、甘草5g。
实施例3
一种治疗风赤疮痍的中药组合物，其中药原料及重量配比为：天青地白25g、小飞扬草10g、毛罗勒20g、凌霄花5g、虎耳草25g、匍伏堇10g、紫草20g、三颗针5g、莲蓬草25g、半边旗10g、地柑20g、白花猪母菜5g、鸭儿芹25g、水蓼10g、四季青20g、天葵子5g、老虎泡25g、刺郎果10g、楼梯草20g、铜锤玉带草5g、甘草8g。
实施例4
一种治疗风赤疮痍的中药组合物，其中药原料及重量配比为：天青地白10g、小飞扬草20g、毛罗勒5g、凌霄花5g、虎耳草10g、匍伏堇20g、紫草5g、三颗针25g、莲蓬草10g、半边旗20g、地柑5g、白花猪母菜25g、鸭儿芹10g、水蓼20g、四季青5g、天葵子15g、老虎泡10g、刺郎果20g、楼梯草5g、铜锤玉带草25g、甘草12g。
实施例5
一种治疗风赤疮痍的中药组合物，其中药原料及重量配比为：天青地白30g、小飞扬草5g、毛罗勒25g、凌霄花10g、虎耳草20g、匍伏堇5g、紫草18g、三颗针10g、莲蓬草20g、半边旗5g、地柑15g、白花猪母菜10g、鸭儿芹20g、水蓼5g、四季青25g、天葵子12g、老虎泡20g、刺郎果5g、楼梯草18g、铜锤玉带草10g、甘草15g。
为了更好的考察本发明的中药组合物的临床疗效和安全性,用本发明所述的中药组合物的治疗效果进行临床实验。
一、临床病例选择：挑选80例风赤疮痍患者，其中，男43例，女37例，年龄20～60岁。
二、诊断依据：
1、胞睑皮肤红亦，肿胀.出现小泡或丘疹，继则成脓疱，破溃出脓血，或溃烂浸淫；
2、局部刺痒或灼痛，或有畏光，流泪，初起或有发热，头痛等症。重症、变症可见高热、头痛、恶心、呕吐。
三、用法用量：采用实施例1所给出的中药组合物，将中药组合物按传统的水煎法煎煮两遍，取汁约400ml，分早、晚两次空腹温服。治疗期间忌生冷辛辣刺激之物。
四、疗效标准：
1、治愈：胞睑红肿消退，溃烂愈合，症状消失；
2、有效：胞睑红肿减轻，溃烂逐渐收敛，症状减轻；
3、无效：胞睑红肿，溃烂加重，症状加剧，或迁延不愈。
五、治疗效果：该临床观察病例中，服药5-15天，痊愈69例，随访未见复发；有效9例，无效2例。治疗期间对中药品临床引起各类型的过敏反应、疑为药物引起人体各系统、器官、组织的功能和形态方面的异常、疑为药物引起癌症等致突变反应、药物的依赖性以及认为重要或有价值的其他不良反应进行了评价，即中药品不良反应（ADR）评价，未发生不良反应和毒副作用。
六、典型病例：
病例1：
马某，女，27岁。患风赤疮痍一周。诊见：右眼胞睑红肿，脓疱溃烂，苔薄，舌红少津，脉细。服用本发明中药组合物制备的药剂3天，胞睑红肿明显减轻，溃烂逐渐收敛；继续服用5天，胞睑红肿消退，溃烂愈合，症状消失，痊愈。
病例2：
韩某，男，46岁。10天前左眼上睑及其周围皮肤红肿、灼痛，3日后局部皮肤起水疱。曾外搽红霉素眼膏，口服穿心莲片，疗效不佳，现疼痛剧烈，畏光流泪，并伴有高热、头痛、恶心、呕吐等症状。诊见：左眼上睑有许多疱疹，有的已溃烂出脓血。服用本发明中药组合物制备的药剂5天，红肿、灼痛明显减轻，畏光流泪、高热、头痛、恶心、呕吐等症状消失，溃烂逐渐收敛；继续服用5天，红肿、灼痛消失，溃烂愈合，治愈。一年后随访无复发。

Claims (2)

1.一种治疗风赤疮痍的中药组合物，其特征在于：其中药原料及重量份配比为：天青地白10-30份、小飞扬草5-25份、毛罗勒5-25份、凌霄花12份、虎耳草5-25份、匍伏堇5-25份、紫草5-20份、三颗针5-25份、莲蓬草5-25份、半边旗5-25份、地柑5-20份、白花猪母菜5-25份、鸭儿芹5-25份、水蓼5-20份、四季青5-25份、天葵子5-20份、老虎泡5-25份、刺郎果5-25份、楼梯草5-20份、铜锤玉带草5-25份、甘草5-15份。
2.根据权利要求1所述一种治疗风赤疮痍的中药组合物，其特征在于：其中药原料及重量份配比为：天青地白20份、小飞扬草15份、毛罗勒15份、凌霄花12份、虎耳草15份、匍伏堇15份、紫草10份、三颗针15份、莲蓬草15份、半边旗15份、地柑10份、白花猪母菜15份、鸭儿芹15份、水蓼12份、四季青15份、天葵子10份、老虎泡15份、刺郎果15份、楼梯草10份、铜锤玉带草15份、甘草10份。
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