CN107375899A - A kind of animal compound Appetizing spleen-tonifying pharmaceutical composition and preparation method thereof - Google Patents
A kind of animal compound Appetizing spleen-tonifying pharmaceutical composition and preparation method thereof Download PDFInfo
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- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
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Abstract
The present invention relates to a kind of animal compound Appetizing spleen-tonifying pharmaceutical composition and preparation method thereof, raw material includes traditional Chinese medicine ingredients, western medicine composition and auxiliary material, and traditional Chinese medicine ingredients include following components and parts by weight content：15 25 parts of the fruit of glossy privet, 15 25 parts of the bark of eucommia, 5 15 parts of hawthorn, 5 15 parts of the Radix Astragali, 30 50 parts of the compound of glauber-salt and liquorice, western medicine composition are the colistin sulphate of parts by weight 5 15, and auxiliary material includes following components and parts by weight content：5 10 parts of glidant, 36 parts of flavouring.Compared with prior art, the present invention passes through traditional Chinese medicine ingredients and the compatibility of western medicine composition, Appetizing spleen-tonifying, kidney-supplementing liver-boosting, somatotrophic effect can be realized, and lasting medicine, it is not easy to rebound, animal caused by various diseases being alleviated rapidly does not eat, anorexia, has growth promoting function to the growth retardation of animal.
Description
Technical field
The invention belongs to animal-use drug technical field, more particularly, to a kind of animal compound Appetizing spleen-tonifying pharmaceutical composition and
Its preparation method.
Background technology
In the breeding process of animal, due to the various diseases of animal easy infection, adjoint it can often not eat, anorexia.Take
Western medicine can rapid relief of symptoms, make ill domestic animal, the drink of fowl, appetite increase, the state of mind takes a turn for the better, and to the tolerance of epidemic disease significantly
Enhancing, and then the death rate is reduced, reduce the economic loss of plant.Although Western medicine is quick, its hold time it is short, and easily
Bounce-back, easily causes the drug resistance of various pathogens constantly to strengthen, and is broken the microecological balance of animal body in itself, pole
The earth reduces animal immune function.And although Chinese medicine is less to the counter productive of animal, and its Appetizing spleen-tonifying persistent,
Because the effect of Chinese medicine too relaxes, rapid-onset is tended not to, is extremely restricted in practical application.
The content of the invention
It is an object of the present invention to overcome the above-mentioned drawbacks of the prior art and provide a kind of quick and drug effect
Lasting animal compound Appetizing spleen-tonifying pharmaceutical composition and preparation method thereof.
The purpose of the present invention can be achieved through the following technical solutions：
A kind of animal compound Appetizing spleen-tonifying pharmaceutical composition, including traditional Chinese medicine ingredients, western medicine composition and auxiliary material,
Described traditional Chinese medicine ingredients include following components and parts by weight content：Fruit of glossy privet 15-25 parts, bark of eucommia 15-25 parts, hawthorn
5-15 parts, Radix Astragali 5-15 parts, compound of glauber-salt and liquorice 30-50 parts,
Described western medicine composition is parts by weight 5-15 colistin sulphate,
Described auxiliary material includes following components and parts by weight content：Glidant 5-10 parts, flavouring 3-6 parts.
The preferred following components of described traditional Chinese medicine ingredients and parts by weight content：Fruit of glossy privet 18-22 parts, bark of eucommia 18-22 parts, hawthorn
8-12 parts, Radix Astragali 8-12 parts, compound of glauber-salt and liquorice 35-45 parts, described western medicine composition preferred weight part 8-12 colistin sulphate are described
The preferred following components of auxiliary material and parts by weight content：Glidant 6-8 parts, flavouring 4-5 parts.
Described traditional Chinese medicine ingredients also include parts by weight 3-7 Chinese yam.
Described traditional Chinese medicine ingredients also include the parts by weight 2-5 banksia rose.
Described western medicine composition also includes parts by weight 1-4 Pehanorm.
Described glidant is talcum powder and/or superfine silica gel powder.
One or more of the described flavouring in sucrose, lactose or stevioside.
Described auxiliary material also includes parts by weight 5-9 aluzyme.
The preparation method of animal compound Appetizing spleen-tonifying pharmaceutical composition, specifically includes following steps：
1) it is 50-100 mesh that particle diameter is crushed to after traditional Chinese medicine ingredients are dried, and adds auxiliary material afterwards, and be well mixed；
2) western medicine composition is added, after being well mixed, that is, described animal compound Appetizing spleen-tonifying pharmaceutical composition is made.
In the present invention, the main function of traditional Chinese medicine ingredients each component is as follows：
The fruit of glossy privet：It is nourishing liver and kidney, strengthening waist and knee.Yin asthenia generating intrinsic heat, waist is powerless, kidney deficiency involuntary emission.
The bark of eucommia：Filling liver kidney, strengthening the bones and muscles are antiabortive.Lumbago due to the kidney deficiency, waist is powerless, arthralgia pain due to rheumatism, fetal irritability.
Hawthorn：Promoting digestion and removing indigestion, scattered stasis.Dyspeptic abdominal flatulence, indigestion, prolonged lochia.
The Radix Astragali：Tonifying Qi and lifting yang, benefit defend solid table, inducing diuresis for removing edema, pus draining and toxin expelling, expelling pus and promoting granulation.Asthenia of pulmonosplenic qi, the sinking of qi of middle-jiao,
Exterior deficiency spontaneous perspiration, deficiency of vital energy oedema, sore carbuncle is difficult to burst, burst for a long time and does not holds back.
The compound of glauber-salt and liquorice：Purgating heat and bowels, moistening for dryness and softening hard mass, detumescence of relieving inflammation or internal heat.Real heat constipation, excrement is constipated, and stagnate stomachache, and throat swells
Bitterly, aphthae, hot eyes, carbuncle swells.
Chinese yam：Tonifying spleen nourishing the stomach, engender liquid and benefic lung, the puckery essence of kidney tonifying.For spleen eating less, endless diarrhea, the deficiency syndrome of the lung is breathed with cough, and kidney deficiency is lost
Essence, with, frequent micturition, abnormal heat is quenched one's thirst.Rhizoma Dioscoreae (parched with bran) good efficacy to suffering from a deficiency of the kidney.For spleen eating less, diarrhea loose stool, leukorrhea..
The banksia rose：Promoting qi circulation and relieving pain, reinforcing spleen to promote digestion.For chest side of body, abdominal distention, weight after rush down dysentery, dyspepsia, do not feel like eating.
Roasted RADIX AUCKLANDIAE reality intestines antidiarrheal.For stomachache of having loose bowels.
The main function of western medicine composition each component is as follows：
Colistin sulphate：Colistin category polypeptide antimicrobial, be a kind of alkaline kation surfactant, by with bacterium
Phosphatide interaction in cell membrane, penetrates into bacterial cell membrane, destroys its structure, and then causes membrane permeability to change,
Cause bacterial death, produce bactericidal action.This product to aerobic bacteria, Escherichia coli, haemophilus, Klebsiella, Pasteurella,
The Gram-negative bacterias such as pseudomonas aeruginosa, salmonella, Shigella have stronger antibacterial action.Sensitive to colistin is thin
Bacterium seldom produces drug resistance.Proteus and most of Serratieaes are not influenceed by colistin.Gram-positive bacteria is generally unwise
Sense.
Pehanorm：It is (such as acute for metabolic acidosis (such as serious dehydration acid poisoning), respiratory acidosis
Respiratory failure, bronchial astehma persistent state, openheart surgery heartbeat stop etc.), cardiac resuccitation etc., to the effect of mixed acidosis
Fruit is more preferable.
The main function of auxiliary material each component is as follows：
Glidant：Frictional force of each component in mixing is reduced, significantly improves the mobility of powder or particle.
Flavouring：The bitter taste of medicine, peculiar smell, stink, excitant are covered, improves mouthfeel, improves animal palatability, is promoted dynamic
The feeding of thing.
Aluzyme：It is a kind of nutritious supplementary pharmaceutical containing abundant B family vitamin, amino acid and trace element chromium.Aluzyme
Containing vitamin B1 and B2, nicotinic acid and some amino acid, animal intestines and stomach can be promoted to wriggle, be advantageous to alleviation medicine and stomach is made
Into discomfort.
Compared with prior art, the invention has the characteristics that：
1) traditional Chinese medicine ingredients and the compatibility of western medicine composition, energy Appetizing spleen-tonifying, kidney-supplementing liver-boosting, somatotrophic effect, and medicine are passed through
Effect is lasting, is not easy to rebound, various diseases can be alleviated rapidly caused by animal do not eat, anorexia, have to the growth retardation of animal
Growth promoting function；
2) toxic side effect is small, easily prepared, and cost is cheap.
Embodiment
With reference to specific embodiment, the present invention is described in detail.Following examples will be helpful to the technology of this area
Personnel further understand the present invention, but the invention is not limited in any way.It should be pointed out that the ordinary skill to this area
For personnel, without departing from the inventive concept of the premise, various modifications and improvements can be made.These belong to the present invention
Protection domain.
Embodiment 1：
A kind of animal compound Appetizing spleen-tonifying pharmaceutical composition, the pharmaceutical composition include traditional Chinese medicine ingredients, western medicine composition and auxiliary
Material, traditional Chinese medicine ingredients include following components and parts by weight content：It is 15 parts of the fruit of glossy privet, 15 parts of the bark of eucommia, 5 parts of hawthorn, 5 parts of the Radix Astragali, profound bright
30 parts of powder, western medicine composition include following components and parts by weight content：5 parts of colistin sulphate, auxiliary material include following components and weight
Part content：3 parts of 10 parts of glidant and flavouring.
Wherein, glidant is talcum powder；Flavouring is lactose.
The preparation method of the pharmaceutical composition specifically includes following steps：
1) after traditional Chinese medicine ingredients are dried, it is 50-100 mesh to be crushed to particle diameter, adds auxiliary material afterwards, and be well mixed；
2) western medicine composition is added, after being well mixed, that is, animal compound Appetizing spleen-tonifying pharmaceutical composition is made.
Embodiment 2：
A kind of animal compound Appetizing spleen-tonifying pharmaceutical composition, the pharmaceutical composition include traditional Chinese medicine ingredients, western medicine composition and auxiliary
Material, traditional Chinese medicine ingredients include following components and parts by weight content：It is 20 parts of the fruit of glossy privet, 20 parts of the bark of eucommia, 10 parts of hawthorn, 10 parts of the Radix Astragali, profound
Bright 40 parts of powder, 5 parts of Chinese yam, 5 parts of the banksia rose, western medicine composition include following components and parts by weight content：10 parts of colistin sulphate, three hydroxyls
1 part of methyl methylamine, auxiliary material include following components and parts by weight content：9 parts of 5 parts of glidant, 6 parts of flavouring and aluzyme.
Wherein, glidant is superfine silica gel powder；Flavouring is sucrose.
The preparation method of the pharmaceutical composition specifically includes following steps：
1) after traditional Chinese medicine ingredients are dried, it is 50-100 mesh to be crushed to particle diameter, adds auxiliary material afterwards, and be well mixed；
2) western medicine composition is added, after being well mixed, that is, animal compound Appetizing spleen-tonifying pharmaceutical composition is made.
Embodiment 3：
A kind of animal compound Appetizing spleen-tonifying pharmaceutical composition, the pharmaceutical composition include traditional Chinese medicine ingredients, western medicine composition and auxiliary
Material, traditional Chinese medicine ingredients include following components and parts by weight content：It is 18 parts of the fruit of glossy privet, 18 parts of the bark of eucommia, 8 parts of hawthorn, 8 parts of the Radix Astragali, profound bright
36 parts of powder, 8 parts of Chinese yam, 8 parts of the banksia rose, western medicine composition include following components and parts by weight content：6 parts of colistin sulphate, three hydroxyl first
4 parts of base methylamine, auxiliary material include following components and parts by weight content：8 parts of glidant, 4 parts of flavouring, 5 parts of aluzyme.
Wherein, glidant includes talcum powder and superfine silica gel powder；Flavouring includes lactose and stevioside.
The preparation method of the pharmaceutical composition specifically includes following steps：
1) after traditional Chinese medicine ingredients are dried, it is 50-100 mesh to be crushed to particle diameter, adds auxiliary material afterwards, and be well mixed；
2) western medicine composition is added, after being well mixed, that is, animal compound Appetizing spleen-tonifying pharmaceutical composition is made.
Embodiment 4：
A kind of animal compound Appetizing spleen-tonifying pharmaceutical composition, the pharmaceutical composition include traditional Chinese medicine ingredients, western medicine composition and auxiliary
Material, traditional Chinese medicine ingredients include following components and parts by weight content：It is 22 parts of the fruit of glossy privet, 22 parts of the bark of eucommia, 9 parts of hawthorn, 9 parts of the Radix Astragali, profound bright
38 parts of powder, 8 parts of Chinese yam, 8 parts of the banksia rose, western medicine composition include following components and parts by weight content：8 parts of colistin sulphate, three hydroxyl first
2 parts of base methylamine, auxiliary material include following components and parts by weight content：6 parts of glidant, 5 parts of flavouring, 7 parts of aluzyme.
Wherein, glidant is talcum powder；Flavouring includes sucrose and stevioside.
The preparation method of the pharmaceutical composition specifically includes following steps：
1) after traditional Chinese medicine ingredients are dried, it is 50-100 mesh to be crushed to particle diameter, adds auxiliary material afterwards, and be well mixed；
2) western medicine composition is added, after being well mixed, that is, animal compound Appetizing spleen-tonifying pharmaceutical composition is made.
Embodiment 5：
A kind of animal compound Appetizing spleen-tonifying pharmaceutical composition, the pharmaceutical composition include traditional Chinese medicine ingredients, western medicine composition and auxiliary
Material, traditional Chinese medicine ingredients include following components and parts by weight content：It is 30 parts of the fruit of glossy privet, 30 parts of the bark of eucommia, 20 parts of hawthorn, 20 parts of the Radix Astragali, profound
Bright 45 parts of powder, 10 parts of Chinese yam, 10 parts of the banksia rose, western medicine composition include following components and parts by weight content：5 parts of colistin sulphate, three
3 parts of methylol methylamine, auxiliary material include following components and parts by weight content：7 parts of glidant, 4.5 parts of flavouring, 8 parts of aluzyme.
Wherein, glidant is superfine silica gel powder；Flavouring includes sucrose, lactose and stevioside.
The preparation method of the pharmaceutical composition specifically includes following steps：
1) after traditional Chinese medicine ingredients are dried, it is 50-100 mesh to be crushed to particle diameter, adds auxiliary material afterwards, and be well mixed；
2) western medicine composition is added, after being well mixed, that is, animal compound Appetizing spleen-tonifying pharmaceutical composition is made.
Comparative example：
Clinical test is carried out to obtained animal compound Appetizing spleen-tonifying pharmaceutical composition in embodiment 1, it is specific as follows：
1st, materials and methods
1.1 case sources：Technical staff is gathering clinical swine influenza heating appetite in the area such as Jiangxi, Fujian not just
Case 300, chicken " proventriculitis " are also known as " muscular stomach cutin membrane scorching " case 150, chicken intestinal diorder is had loose bowels case 150 and popular taste
Real heat disease case 600, stochastic averagina are divided into three groups, and every group of case load is identical.
1.2 case diagnosis：With natural cases according to epidemiology, clinical symptoms, pathological change, Laboratory Diagnosed.
1.3 implementation process：Case treatment, and log are carried out by technical staff.
1.4 usage and dosage：Natural cases are puddled into nursing by feed, takes orally and uses；2g medicine groups are added in per 1kg feeds
Compound, feeding daily is once；Pig, dog are used in conjunction 5, and chicken, duck are used in conjunction 4.
1.5 result judgement
Cure：After prescriptive procedure, number medication, livestock and poultry illness is wholly absent, and spirit, body temperature, appetite recover normal, urine
Liquid excrement is normal.
It is effective：After prescriptive procedure, number medication, livestock and poultry illness disappears substantially, and spirit, body temperature, appetite make moderate progress, urine
Liquid excrement is normal.
It is invalid：After prescriptive procedure, number medication, livestock and poultry illness does not disappear, and sb.'s illness took a turn for the worse or dead, body temperature, spirit, urine
Liquid stool colour, character are abnormal.
Wherein, effective case statistics includes the case cured, and effective percentage accounts for the percentage of total case for effective case.
1.6 medicine：
Animal compound Appetizing spleen-tonifying pharmaceutical composition：Prepared using embodiment 1.
Bark of eucommia hawthorn dissipates：Quality standard is dissipated according to No. 1759 bark of eucommia hawthorn of the Ministry of Agriculture, is prepared in laboratory.
2nd, test method
2.1 experiment packets：
It is divided into animal compound Appetizing spleen-tonifying pharmaceutical composition group, bark of eucommia hawthorn dissipates three groups of group and blank control group, sky
White control group is not administered.As a result it is as shown in the table：
3. treatment results
As can be seen from the above table：Animal compound Appetizing spleen-tonifying pharmaceutical composition group dissipates group, blank control group with bark of eucommia hawthorn
Compare, therapeutic effect is significantly improved, and reaches more than 92% to the effective percentage of animal treating correlative diseases, quick, and drug effect is held
Long.
Embodiment 6：
A kind of animal compound Appetizing spleen-tonifying pharmaceutical composition, including traditional Chinese medicine ingredients, western medicine composition and auxiliary material,
Traditional Chinese medicine ingredients include following components and parts by weight content：15 parts of the fruit of glossy privet, 15 parts of the bark of eucommia, 5 parts of hawthorn, 5 parts of the Radix Astragali,
30 parts of the compound of glauber-salt and liquorice, western medicine composition are the colistin sulphate of parts by weight 5, and auxiliary material includes following components and parts by weight content：Glidant
5 parts of talcum powder, 3 parts of flavouring sucrose.
The preparation method of animal compound Appetizing spleen-tonifying pharmaceutical composition, specifically includes following steps：
1) it is 50 mesh that particle diameter is crushed to after traditional Chinese medicine ingredients are dried, and adds auxiliary material afterwards, and be well mixed；
2) western medicine composition is added, after being well mixed, that is, described animal compound Appetizing spleen-tonifying pharmaceutical composition is made.
Embodiment 7：
A kind of animal compound Appetizing spleen-tonifying pharmaceutical composition, including traditional Chinese medicine ingredients, western medicine composition and auxiliary material,
Traditional Chinese medicine ingredients include following components and parts by weight content：18 parts of the fruit of glossy privet, 18 parts of the bark of eucommia, 8 parts of hawthorn, 8 parts of the Radix Astragali,
35 parts of the compound of glauber-salt and liquorice, 2 parts of the banksia rose, Western medicine include following components and parts by weight content：1 part of Pehanorm, colistin sulphate 8
Part, auxiliary material is following components and parts by weight content：6 parts of glidant superfine silica gel powder, 4 parts of flavouring lactose, 5 parts of aluzyme.
The preparation method of animal compound Appetizing spleen-tonifying pharmaceutical composition, specifically includes following steps：
1) it is 80 mesh that particle diameter is crushed to after traditional Chinese medicine ingredients are dried, and adds auxiliary material afterwards, and be well mixed；
2) western medicine composition is added, after being well mixed, that is, described animal compound Appetizing spleen-tonifying pharmaceutical composition is made.
Embodiment 8：
A kind of animal compound Appetizing spleen-tonifying pharmaceutical composition, including traditional Chinese medicine ingredients, western medicine composition and auxiliary material,
Described traditional Chinese medicine ingredients include following components and parts by weight content：22 parts of the fruit of glossy privet, 22 parts of the bark of eucommia, 12 parts of hawthorn,
12 parts of the Radix Astragali, 45 parts of the compound of glauber-salt and liquorice, 7 parts of Chinese yam, 5 parts of the banksia rose, Western medicine include following components and parts by weight content：Pehanorm
4 parts, 12 parts of colistin sulphate, auxiliary material use following components and parts by weight content：The glidant 8 that talcum powder and superfine silica gel powder are formed
5 parts of the flavouring, 9 parts of aluzyme of part, lactose and stevioside composition.
The preparation method of animal compound Appetizing spleen-tonifying pharmaceutical composition, specifically includes following steps：
1) it is 60 mesh that particle diameter is crushed to after traditional Chinese medicine ingredients are dried, and adds auxiliary material afterwards, and be well mixed；
2) western medicine composition is added, after being well mixed, that is, described animal compound Appetizing spleen-tonifying pharmaceutical composition is made.
Embodiment 9：
A kind of animal compound Appetizing spleen-tonifying pharmaceutical composition, including traditional Chinese medicine ingredients, western medicine composition and auxiliary material,
Described traditional Chinese medicine ingredients include following components and parts by weight content：25 parts of the fruit of glossy privet, 25 parts of the bark of eucommia, 15 parts of hawthorn,
15 parts of the Radix Astragali, 50 parts of the compound of glauber-salt and liquorice, western medicine composition are the colistin sulphate of 15 parts of parts by weight, and auxiliary material includes following components and parts by weight
Content：10 parts of superfine silica gel powder glidant, 6 parts of stevioside flavouring.
The preparation method of animal compound Appetizing spleen-tonifying pharmaceutical composition, specifically includes following steps：
1) it is 100 mesh that particle diameter is crushed to after traditional Chinese medicine ingredients are dried, and adds auxiliary material afterwards, and be well mixed；
2) western medicine composition is added, after being well mixed, that is, described animal compound Appetizing spleen-tonifying pharmaceutical composition is made.
The specific embodiment of the present invention is described above.It is to be appreciated that the invention is not limited in above-mentioned
Particular implementation, those skilled in the art can make various deformations or amendments within the scope of the claims, this not shadow
Ring the substantive content of the present invention.
Claims (10)
1. a kind of animal compound Appetizing spleen-tonifying pharmaceutical composition, it is characterised in that said composition includes traditional Chinese medicine ingredients, western medicine composition
And auxiliary material,
Described traditional Chinese medicine ingredients include following components and parts by weight content：Fruit of glossy privet 15-25 parts, bark of eucommia 15-25 parts, hawthorn 5-15
Part, Radix Astragali 5-15 parts, compound of glauber-salt and liquorice 30-50 parts,
Described western medicine composition is parts by weight 5-15 colistin sulphate,
Described auxiliary material includes following components and parts by weight content：Glidant 5-10 parts, flavouring 3-6 parts.
A kind of 2. animal compound Appetizing spleen-tonifying pharmaceutical composition according to claim 1, it is characterised in that described Chinese medicine
The preferred following components of composition and parts by weight content：Fruit of glossy privet 18-22 parts, bark of eucommia 18-22 parts, hawthorn 8-12 parts, Radix Astragali 8-12 parts,
Compound of glauber-salt and liquorice 35-45 parts, described western medicine composition preferred weight part 8-12 colistin sulphate, the preferred following components of described auxiliary material
And parts by weight content：Glidant 6-8 parts, flavouring 4-5 parts.
3. a kind of animal compound Appetizing spleen-tonifying pharmaceutical composition according to claim 1 or 2, it is characterised in that described
Traditional Chinese medicine ingredients also include parts by weight 3-7 Chinese yam.
4. a kind of animal compound Appetizing spleen-tonifying pharmaceutical composition according to claim 1 or 2, it is characterised in that described
Traditional Chinese medicine ingredients also include the parts by weight 2-5 banksia rose.
5. a kind of animal compound Appetizing spleen-tonifying pharmaceutical composition according to claim 1 or 2, it is characterised in that described
Western medicine composition also includes parts by weight 1-4 Pehanorm.
6. a kind of animal compound Appetizing spleen-tonifying pharmaceutical composition according to claim 1 or 2, it is characterised in that described
Glidant is talcum powder and/or superfine silica gel powder.
7. a kind of animal compound Appetizing spleen-tonifying pharmaceutical composition according to claim 1 or 2, it is characterised in that described
One or more of the flavouring in sucrose, lactose or stevioside.
8. a kind of animal compound Appetizing spleen-tonifying pharmaceutical composition according to claim 1 or 2, it is characterised in that described
Auxiliary material also includes parts by weight 5-9 aluzyme.
9. the preparation method of animal compound Appetizing spleen-tonifying pharmaceutical composition as claimed in claim 1, it is characterised in that this method
Specifically include following steps：
1) crushed after traditional Chinese medicine ingredients are dried, add auxiliary material afterwards, and be well mixed；
2) western medicine composition is added, after being well mixed, that is, described animal compound Appetizing spleen-tonifying pharmaceutical composition is made.
10. a kind of preparation method of animal compound Appetizing spleen-tonifying pharmaceutical composition according to claim 9, its feature exist
In in step 1), after traditional Chinese medicine ingredients are dried, it is 50-100 mesh to be crushed to particle diameter.
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