CN107375799A - A kind of gynecological external use antibacterial powder and preparation method thereof - Google Patents

A kind of gynecological external use antibacterial powder and preparation method thereof Download PDF

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Publication number
CN107375799A
CN107375799A CN201710654288.8A CN201710654288A CN107375799A CN 107375799 A CN107375799 A CN 107375799A CN 201710654288 A CN201710654288 A CN 201710654288A CN 107375799 A CN107375799 A CN 107375799A
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parts
chinese
antibacterial powder
external use
standby
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王勇军
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Guilin Commoner Pharmaceutical Co Ltd
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Guilin Commoner Pharmaceutical Co Ltd
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
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    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract

Gynecologic medicine technical field of the present invention, more particularly to a kind of gynecological external use antibacterial powder and preparation method thereof, mainly it is made up of raw materials such as the radix paeoniae rubrathe, setose thistle, field thistle, frutus cnidii, the fruit of summer cypress, rosin, rhizoma atractylodis, Java brucea, alkanet, the windproof, tuber of stemona, Chinese actinidia root, the achene of Siberian cocklebur, indigo naturalis, Chinese sumac, Honeysuckle bine, schizonepeta, peppermint, Chinese ephedra, glycine betaine, the dried rhizome of rehmannia, radix scrophulariae, cloves, the root bark of Chinese wolf-berry, borneol, Patrinia heterophylla, cordate telosma, tangerine alum, color stabilizer, surfactant, complex enzyme and microorganisms through steps such as Feedstock treating, enzymolysis, fermentation, alcohol precipitation, concentrations.The antibacterial powder has the multi-efficiencies such as dispelling wind clearing damp, clearing heat and detoxicating, enriching the blood to restore normal menstruation, promoting blood circulation and removing blood stasis, Anti-Puritic and insecticidal, antimicrobial antiphlogistic and hemostasis and pain-relieving, there is good remission effect to gynecological disease, effectively improve body immunity, have no side effect and drug resistance, and its preparation technology is simple, easily make.

Description

A kind of gynecological external use antibacterial powder and preparation method thereof
Technical field
The present invention relates to gynecologic medicine technical field, and in particular to a kind of gynecological external use antibacterial powder and preparation method thereof.
Background technology
Various gynaecological inflammation diseases and cutaneous pruritus are of common occurrence in daily life.Therefore to the demand of such product Amount is also very big.There are the also many of the diseases such as redness, desolation in some part population skin.The gynecological disease of China's treatment at present can It is divided into the two kinds of treatments of doctor trained in Western medicine and the traditional Chinese medical science, doctor trained in Western medicine uses estrogen and antibacterials therapeutic alliance more, but long-term use can produce Different degrees of degree side effect and drug resistance, and the traditional Chinese medical science thinks, it is main for what is caused a disease that ailment said due to cold or exposure, damp evil, heat evil, the deficiency of blood, worm are excessive etc. Reason, treatment should be helped using dispelling wind clearing damp, clearing heat and detoxicating, enriching the blood to restore normal menstruation, promoting blood circulation and removing blood stasis and Anti-Puritic and insecticidal as principle with reaching to get rid of evils The effect of just antipruritic, beneficial to suiting the remedy to the case for gynecological disease, there is good remission effect, and without any harmful effect and resistance to The property of medicine.
The content of the invention
The goal of the invention of the present invention is：For above-mentioned problem, there is provided a kind of gynecological external use antibacterial powder and its system Preparation Method, the antibacterial powder have dispelling wind clearing damp, clearing heat and detoxicating, enriching the blood to restore normal menstruation, promoting blood circulation and removing blood stasis, Anti-Puritic and insecticidal, antimicrobial antiphlogistic and stopped The multi-efficiencies such as blood and relieving pain, there is good remission effect to gynecological disease, moreover it is possible to effectively improve body immunity, have no side effect and Drug resistance, and its preparation technology is simple, easily makes.
To achieve these goals, the technical solution adopted by the present invention is as follows：
A kind of gynecological external use antibacterial powder, is mainly made up of following raw material：Radix paeoniae rubrathe 27-30 parts, setose thistle 25-27 parts, Field thistle 25-27 parts, frutus cnidii 24-26 parts, fruit of summer cypress 23-25 parts, rhizoma atractylodis 20-22 parts, Java brucea 20-22 parts, alkanet 18-20 Part, windproof 18-20 parts, tuber of stemona 18-20 parts, rosin 15-17 parts, Chinese actinidia root 12-14 parts, achene of Siberian cocklebur 12-14 parts, indigo naturalis 10-13 It is part, Chinese sumac 10-13 parts, Honeysuckle bine 10-15 parts, schizonepeta 10-15 parts, peppermint 7-9 parts, Chinese ephedra 7-9 parts, dried rhizome of rehmannia 6-7 parts, profound Join 6-8 parts, cloves 5-6 parts, glycine betaine 5-6 parts, root bark of Chinese wolf-berry 3-4 parts, Patrinia heterophylla 3-4 parts, cordate telosma 2-3 parts, borneol 2-3 parts, Tangerine alum 2-3 parts, color stabilizer 1-2 parts, surfactant 0.3-0.5 parts, complex enzyme 1-1.5 parts and microorganism 0.5-0.7 parts.
Preferably, mainly it is made up of following raw material：28.5 parts of the radix paeoniae rubrathe, 26 parts of setose thistle, 26 parts of field thistle, frutus cnidii 25 Part, 24 parts of the fruit of summer cypress, 21 parts of rhizoma atractylodis, 21 parts of Java brucea, 19 parts of alkanet, windproof 19 parts, 19 parts of the tuber of stemona, 16 parts of rosin, Chinese gooseberry 13 parts of root, 13 parts of the achene of Siberian cocklebur, 11.5 parts of indigo naturalis, 11.5 parts of Chinese sumac, 13 parts of Honeysuckle bine, 13 parts of schizonepeta, 8 parts of peppermint, Chinese ephedra 8 Part, 6.5 parts of the dried rhizome of rehmannia, 7 parts of radix scrophulariae, 5.5 parts of cloves, 5.5 parts of glycine betaine, 3.5 parts of the root bark of Chinese wolf-berry, 3.5 parts of Patrinia heterophylla, cordate telosma 2.5 Part, 2.5 parts of borneol, 2.5 parts of tangerine alum, 1.5 parts of color stabilizer, 0.4 part of surfactant, 1.3 parts of complex enzyme and 0.6 part of microorganism.
Preferably, the surfactant is fatty acid sorbitan, the zephiran by waiting mass ratio And lecithin mixes.
Preferably, the microorganism is by waiting actinomyces, streptomycete, streptococcus and the saccharomycete of mass ratio to mix.
Preferably, the complex enzyme is by waiting hemicellulase, pectase and the lysozyme of mass ratio to mix.
The preparation method of gynecological external use antibacterial powder as described above, specifically includes following steps：
(1) rosin, borneol, tangerine alum, glycine betaine, color stabilizer, surfactant, thickener, complex enzyme and microorganism will be removed Raw material in addition is soaked in potassium permanganate-salt mixed liquor that mass concentration is 0.1-0.3%, soaks 1- after removal of impurities is cleaned 2h, pick up and rinse and drain surface moisture, shred, it is standby；
(2) raw material after being handled in step (1) is put into enzymatic vessel, and the high pressure for applying 400-600MPa is carried out in advance to raw material Processing, is poured into enzymatic vessel after color stabilizer, complex enzyme are dissolved completely in water, adds distilled water to raw material is not crossed, stirs It is well mixed, enzymolysis 2-3h is carried out at being 50-60 DEG C in temperature, obtains enzymolysis product, it is standby；
(3) enzymolysis product in step (2) is put into the high pressure decoction pot with agitating device, addition accounts for enzymolysis product matter 7-10 times of distilled water of amount, apply pressure 90-100KPa, be heated to temperature as 100-120 DEG C, decocted simultaneously while stirring Boil and destroy the enzyme treatment, decoction product is poured out after 3-4h, it is standby after cooling；
(4) it is dissolved completely in after mixing rosin, borneol, glycine betaine in the absolute ethyl alcohol that volumetric concentration is 60-70%, will Tangerine alum is poured into the solution of the former dissolving after being dissolved in water, is uniformly mixed to obtain mixed liquor, standby；
(5) glycine betaine will be dissolved in warm water, and be put into microorganism and carries out activation 3-5h, and leavening be made, in step (4) Mixed liquor is poured into fermentation tank with decocting product in step (3), is added leavening, is uniformly mixed sealing, carries out at fermentation Reason, it is standby by obtaining zymotic fluid after high-pressure filteration；
(6) 1/3-1/2 for the fermentating liquid volume for accounting for step (5) organic solvent is measured, surfactant is dissolved in organic In solvent, it is subsequently poured into the zymotic fluid of step (5), after being uniformly mixed, enters in the case where temperature is 45-55 DEG C and nitrogen is protected Row refluxing extraction 5-6h, through centrifugal filtration, filtered fluid is obtained, it is standby；
(7) filtered fluid of step (6) is subjected to cryogenic vacuum distillation and concentration, it is 1.0-1.2g/cm to be concentrated into density3, system Condensed cream is obtained, condensed cream carries out high pressure forced air drying and particle decentralized processing by high pressure blower, and drying is small to dry cream moisture In 5%, 50-60 mesh sieves are crossed, obtain the gynecological external use antibacterial powder, are packed, are put in storage.
Preferably, organic solvent described in step (6) be by isometric ratio normal butane, isopropanol and chloroform mixing and Into.
In summary, by adopting the above-described technical solution, the beneficial effects of the invention are as follows：
The pharmacological properties of the part Chinese herbal medicine used below for the present invention：
The radix paeoniae rubrathe：Classification system：Paeonia veitchii Lynch, it is pungent, it is bitter, it is slightly cold, Return liver, the heart channel of Hang-Shaoyin, containing paeonol, benzene The chemical compositions such as formic acid, tannin, volatile oil, carrot sterol, it is also a variety of containing Paeoniflorin, Chinese herbaceous peony lactones glucoside, oxidized paeoniflorin glycosides etc. Glucoside, there is the multiple pharmacological effects such as clearing heat and cooling blood, promoting blood circulation and removing blood stasis, blood stasis removing analgesic, resisting pathogenic microbes, anti-inflammatory.
Rosin：Classification system：Colophonium, it is bitter, sweet, it is warm-natured, enter spleen, lung two passes through, have dispel pathogenic wind and remove dampness, desinsection The effect of antipruritic, apocenosis is drawn out pus by applying a plaster to the affected part, myogenic pain relieving, lower gas evil removing, it is usually used in treating the skin diseases such as eczema, chronic dermatitis.
Frutus cnidii：Classification system：Cnidium monnieri (L.) Cuss, acrid flavour, hardship are warm-natured, there is eliminating dampness wind-dispelling, desinsection Antipruritic, warming kidney and enhancing body etc. acts on, and is usually used in controlling eczema of vulva, married woman's pruritus vulvae, trichomonas vaginitis outside.
The fruit of summer cypress：Classification system：Kochia scoparia (L.) Schrad.f.trichophylla (Hort.), it is cold in nature, Acrid flavour, hardship, containing triterpenoid saponin, there is clearing heat and detoxicating, dampness removing diuresis, dispelling wind and arresting itching, strong improving eyesight, inflammation-dimishing and eye brightening, treating stranguria remove It is damp and hot, the effect of, be usually used in treating pruritus of vagina, eczema of scrotum, nettle rash, the disease such as cutaneous pruritus, psoriasis after subcutaneous ulcer.
Rhizoma atractylodis：Classification system：Atractylodes Lancea (Thunb.) DC, acrid flavour, hardship are warm-natured, returns spleen, stomach, liver Through having the function that to dispel pathogenic wind and remove dampness, antipruritic, invigorating the spleen cold dispelling, improving eyesight ward off dirty, stomach invigorating peace spleen, dissipate wind QI invigorating, being usually used in treating wet Rash, dermatitis erosion ooze out the phase and other are pruritic.
The tuber of stemona：Classification system：Stemona japonica, sweet, bitter, slightly warm in nature, return lung warp, contain substantial amounts of biology The compositions such as alkali, acetic acid, formic acid, malic acid, butanedioic acid, oxalic acid profit, have the effects such as eliminating dampnessization is turbid, desinsection is antipruritic, hemostasis and pain-relieving, It is usually used in scabies, dermatophytosis, enterobiasis and pediculosis etc..
Java brucea：Classification system：Brucea javanica, it is bitter, tremble with fear, it is poisonous, enter large intestine channel, containing alkaloid, glucoside, phenol Property the composition such as composition, bruceolic acid, have that clearing heat and detoxicating, detumescence dampness elimination, antiviral, desinsection, disperse accumulations be stagnant, stop dysentery disease and other effects.
Alkanet：Classification system：Lithospermum erythrorhizon Sieb.et Zucc, it is sweet, salty, tremble with fear, enter Liver, stomach two pass through, the chemistry of a variety of Quinone Pigments such as fatty acids, lithosperman, flavones, tannin and Acetylshikonin and alkannin Composition, there is clearing heat and detoxicating, promoting eruption cool blood, antimicrobial antiphlogistic, blood-stasis-dissipating blood-circulation-promoting, tonifying middle-Jiao and Qi and other effects.
It is windproof：Classification system：Saposhnikovia divaricata (Trucz.) Schischk, it is acrid flavour, sweet, it is warm-natured, Return bladder, liver, the spleen channel, there is the effect such as dispelling wind and eliminating dampness, expel endogenous wind to relieve convulsion, spasmolysis inducing diaphoresis, sweating eliminating the phlegm, analgesia, antimicrobial antiphlogistic, energy Strengthen immunologic function.
Setose thistle：Classification system：Herba Cirsii Japonici Radix Cirsii Japonici, it is cool in nature, bitter, It is sweet, the thoughts of returning home, Liver Channel, containing compositions such as alkaloid, volatile oil, there is clearing heat and detoxicating, cooling blood and hemostasis, eliminating stasis to subdue swelling, anti-inflammation, drop Blood pressure and other effects.
Field thistle：Classification system：Cirsium setosum (Willd.) MB, sweet, bitter, cold, the thoughts of returning home, Liver Channel, containing choline, youngster The compositions such as tea phenol amine substance, saponin, alkaloid, there is eliminating stasis to resolve swelling, antibacterial, cooling blood and hemostasis, removing toxicity for eliminating carbuncles, clearing heat and relieving fidgetness etc. Effect, to Diplococcus pneumopniae, hemolytic streptococcus, corynebacterium diphtheriae, typhoid fever village bacterium, Pseudomonas aeruginosa, shigella dysenteriae, golden yellow grape Coccus etc. has inhibitory action.
The achene of Siberian cocklebur：Classification system：Xanthium sibiricum Patrin ex Widder, pungent, bitter, temperature is slightly poisonous, Return lung passes through, and has wind and heat eliminating, removing toxic substances desinsection, antalgesic-antipruritic, goes wind promoting blood circulation and other effects.
Chinese actinidia root：Classification system：Actinidia arguta (Sieb.＆Zucc) Planch.ex Miq, it is sour and astringent, it is cool, enter Stomach, bladder two pass through, have it is clearing heat and detoxicating, dispel pathogenic wind and remove dampness, hemostasis of subsiding a swelling, dampness removing diuresis and other effects.
Indigo naturalis：Classification system：Indigo Naturalis, salty, cold, enter liver, lung, the heart, stomach, warp, with clearing heat and detoxicating, cool Blood purging the liver of pathogenic fire, the effect such as stagnated fire, anti-bacteria and anti-virus is dissipated, improve body's immunity.
Chinese sumac：Classification system：Rhus chinensis Mill, nature and flavor are sour, salty, cold nature, return kidney channel, nontoxic, have Clearing heat and detoxicating, relaxing tendons and activating collaterals, dissipate stasis of blood hemostasis, relieving diarrhea with astringents, wind-dispelling humidifying are stagnant and other effects.
Honeysuckle bine：Classification system：Lonicera japonica Thunb, it is sweet, it is cold in nature, enter lung, the heart, stomach, gas virtue Perfume (or spice), there is clearing heat and detoxicating, anti-inflammatory, antibacterial, qi-restoratives to treat wind, eliminating evil radiating and other effects.
Schizonepeta：Classification system：Nepeta cataria L, taste is put down, warm-natured, enters lung, Liver Channel, nontoxic, have expel pathogenic wind from the body surface, Promoting eruption sweating, blood-stanching and blood-cooling, antipyretic town phlegm, expelling parasite sterilizing and other effects.
Peppermint：Classification system：Mentha haplocalyx Briq, acrid flavour is cool in nature, return lung, Liver Channel, there is peat-reek, With antisepsis and sterilization, wind-dispelling heat-dissipating, sweating and heat resolving, diuresis resolving sputum, stomach invigorating, aid digestion and other effects, external application can control neuralgia, skin Itch, fash and eczema etc..
The dried rhizome of rehmannia：Classification system：Rehmannia glutinosa Libosch, sweet, bitter, cold in nature, the thoughts of returning home, liver and kidney channel, With clearing heat and cooling blood, nourishing Yin and promoting production of body fluid, cooling blood and hemostasis, antimycotic and other effects.
Radix scrophulariae：Classification system：Scrophularia ningpoensis Hemsl, sweet, bitter, salty, cold nature, return lung, Stomach, kidney channel, mainly containing triterpenoid saponin, volatile oil, alkaloid, iridoids, Phenylpropanoid Glycosides glycoside, still containing phytosterol etc. into Point, there is clearing heat and cooling blood, nourishing Yin and falling fire, anti-inflammatory, antibacterial, analgesia liver protection, anti-oxidant, detoxicating and resolving a mass and other effects.
Cloves：Classification system：Syringa vulgaris, property is pungent, taste temperature, enters lung, spleen, stomach, kidney four and passes through, pattern is simple and elegant, Fragrance, there is warm kidney to drop inverse, antibacterial, worm-expelling, benefiting stomach and stopping pain and other effects, containing caryophyllus oil and eugenol, for pathogenic fungus and Staphylococcus, dysentery and Escherichia coli etc. have inhibitory action.
Chinese ephedra：Classification system：Ephedra sinica Stapf, warm-natured, acrid flavour, slight bitter, rich in alkaloid, there is sweating Cold dispelling, freeing lung and relieving asthma, inducing diuresis for removing edema, antibacterial and other effects.
The root bark of Chinese wolf-berry：Classification system：Cortex Lycii, it is cold in nature, it is sweet, enter lung, liver and kidney channel, there is clearing heat and cooling blood, clearing lung-heat Fall fire, bring down a fever except steaming and other effects.
Cordate telosma：Classification system：Telosma cordata (Burm.F.) Merr, it is sweet, light, it is mild-natured, there is fragrance, have Clear liver and improve vision, removing toxic substances and promoting tissue regeneration and other effects.
Borneol：Classification system：Dipterocarpus turbinatus Gaertn.f, acrid flavour, hardship are cool in nature, the thoughts of returning home, spleen, Lung channel, gas delicate fragrance, containing the sequiterpenes such as Humuleno, beta-elemene, carypohyllene, oleanolic acid, alphitolic acid, asiatic acid, borneol The triterpenoids such as aromatic ketone, dryobalanone, erythrodiol, have heat-clearing dissipates poison, swelling and pain relieving, inducing resuscitation of having one's ideas straightened out, dissipate it is strongly fragrant Fire, screen improving eyesight, desinsection and other effects are gone, there is good itching-relieving action for hot fash.
Patrinia heterophylla：Classification system：PatriniaheterophyllaBunge, it is bitter, sour and astringent, tremble with fear, enter the heart, Liver Channel, have clear Thermal detoxification, eliminating dampness hemostasis, astringing to arrest bleeding and other effects.
Tangerine alum：Sour-puckery flavor, tremble with fear, enter lung, spleen, stomach, large intestine channel, there is dissolving phlegm eliminating dampness, antidiarrheal hemostasis, removing toxic substances desinsection, myogenic Put on flesh and other effects.
The medicine of the anti-curing oncoma of the present invention is mainly by the radix paeoniae rubrathe, setose thistle, field thistle, frutus cnidii, the fruit of summer cypress, rosin, rhizoma atractylodis, crow Courage, alkanet, the windproof, tuber of stemona, Chinese actinidia root, the achene of Siberian cocklebur, indigo naturalis, Chinese sumac, Honeysuckle bine, schizonepeta, peppermint, Chinese ephedra, beet The raw materials such as alkali, the dried rhizome of rehmannia, radix scrophulariae, cloves, the root bark of Chinese wolf-berry, borneol, Patrinia heterophylla, cordate telosma and tangerine alum through Feedstock treating, enzymolysis, fermentation, Alcohol precipitation, concentration, drying and other steps are made.
It is the radix paeoniae rubrathe, setose thistle, field thistle, frutus cnidii, the fruit of summer cypress, rosin, rhizoma atractylodis, Java brucea, alkanet, windproof in above-mentioned raw materials And tuber of stemona composition monarch drug in a prescription, containing glycoside and terpenoid, have clearing heat and cooling blood, it is promoting blood circulation and removing blood stasis, dispel pathogenic wind and remove dampness, desinsection is antipruritic, The effect of apocenosis is drawn out pus by applying a plaster to the affected part, antimicrobial antiphlogistic, hemostasis and pain-relieving, immunologic function can be strengthened, and rosin has viscosity, can bond each medicine Together, medicine denseness is strengthened；Chinese actinidia root, the achene of Siberian cocklebur, indigo naturalis, Chinese sumac, Honeysuckle bine and schizonepeta composition ministerial drug, have heat-clearing Removing toxic substances, detumescence hemostasis, removing toxic substances desinsection, antalgesic-antipruritic, dispel pathogenic wind and remove dampness, anti-inflammatory, antibacterial the effect of；Peppermint, Chinese ephedra, glycine betaine, life Ground, radix scrophulariae and cloves composition adjutant, containing a variety of alkaloids, have the effect of clearing heat and cooling blood, antibacterial, worm-expelling, anti-inflammatory analgesic；Sweet tea Dish alkali is beneficial to fermentation and promotes wound healing, is zwitterionic surfactant, is extracted beneficial to medicine；The root bark of Chinese wolf-berry, borneol, tomb head Return, cordate telosma and tangerine alum composition make medicine, have clearing heat and cooling blood, removing toxic substances and promoting tissue regeneration, swelling and pain relieving, removing toxic substances desinsection the effect of；Wherein fourth Perfume, rosin, cordate telosma and peppermint all have special fragrance, can remove or cover the peculiar smell of body；These material combinations are made Into gynecological external use antibacterial powder have concurrently clearing heat and cooling blood, it is promoting blood circulation and removing blood stasis, dispel pathogenic wind and remove dampness, desinsection is antipruritic, apocenosis is drawn out pus by applying a plaster to the affected part, antimicrobial antiphlogistic, The multi-efficiencies such as hemostasis and pain-relieving, to urinary tract infections, change that heat toxin, scabies leprosy tinea sore, disappear all sores, the erosion of vulva are wet to itch, control trichomonas vagina Scorching, impetigo poison, detumescence poison, acute purulent lymphadenitis, Persistent Pain, wash Ci leprosys etc. and have the effect of certain, can auxiliary treatment gynaecological imflammation, control trichomonad Property the gynecological disease such as vaginitis, moreover it is possible to remove or cover the peculiar smell of body, increase body note.
These raw materials undergo microbial fermentation in manufacturing process, are preferably decomposed the active ingredient in raw material, Improve recovery rate, and various metabolites caused by microorganism (such as various acids, enzyme, antibiotic, bacteriocidin, growth promotion because Son etc.) also it is mixed in product, harmful bacteria growing can be suppressed, improve the quality of product；Surface is added in the extraction process of Chinese medicine Activating agent, medicinal material is fully soaked so that enough thin of the thickness of liquid film between medicinal material and extractant, reduce active ingredient from Medicinal material diffusion into the surface accelerates the speed of extraction, saves extraction time to the resistance during extractant.
Embodiment
Technical scheme will be clearly and completely described below, it is clear that described embodiment is only Part of the embodiment of the present invention, rather than whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art The every other embodiment obtained under the premise of creative work is not made, belongs to the scope of protection of the invention.
Unless otherwise defined, all of technologies and scientific terms used here by the article is with belonging to technical field of the invention The implication that technical staff is generally understood that is identical.Term used in the description of the invention herein is intended merely to description tool The purpose of the embodiment of body, it is not intended that in the limitation present invention.Term as used herein " and/or " include one or more phases The arbitrary and all combination of the Listed Items of pass.
Embodiment 1
A kind of gynecological external use antibacterial powder, is mainly made up of following raw material：27 parts of the radix paeoniae rubrathe, 25 parts of setose thistle, field thistle 25 Part, 24 parts of frutus cnidii, 23 parts of the fruit of summer cypress, 20 parts of rhizoma atractylodis, 20 parts of Java brucea, 18 parts of alkanet, windproof 18 parts, 18 parts of the tuber of stemona, pine Fragrant 15 parts, 12 parts of Chinese actinidia root, 12 parts of the achene of Siberian cocklebur, 10 parts of indigo naturalis, 10 parts of Chinese sumac, 10 parts of Honeysuckle bine, 10 parts of schizonepeta, peppermint 7 Part, 7 parts of Chinese ephedra, 6 parts of the dried rhizome of rehmannia, 6 parts of radix scrophulariae, 5 parts of cloves, 5 parts of glycine betaine, 3 parts of the root bark of Chinese wolf-berry, 3 parts of Patrinia heterophylla, 2 parts of cordate telosma, ice 0.5 part of 2 parts of piece, 2 parts of tangerine alum, 1 part of color stabilizer, 0.3 part of surfactant, 1 part of complex enzyme and microorganism；
Surfactant is fatty acid sorbitan, zephiran and the lecithin mixing by waiting mass ratio Form；
Microorganism is by waiting actinomyces, streptomycete, streptococcus and the saccharomycete of mass ratio to mix；
The complex enzyme is by waiting hemicellulase, pectase and the lysozyme of mass ratio to mix.
The expectation of said ratio is prepared into gynecological external use antibacterial powder using following methods and specifically includes following steps：
(1) rosin, borneol, tangerine alum, glycine betaine, color stabilizer, surfactant, thickener, complex enzyme and microorganism will be removed Raw material in addition is soaked in potassium permanganate-salt mixed liquor that mass concentration is 0.1%, soaks 2h, pick up after removal of impurities is cleaned Rinse and drain surface moisture, shred, it is standby；
(2) raw material after being handled in step (1) is put into enzymatic vessel, and the high pressure for applying 400MPa is located in advance to raw material Reason, is poured into enzymatic vessel after color stabilizer, complex enzyme are dissolved completely in water, adds distilled water to raw material is not crossed, stirring is mixed Close uniformly, carry out enzymolysis 3h at being 50 DEG C in temperature, obtain enzymolysis product, it is standby；
(3) enzymolysis product in step (2) is put into the high pressure decoction pot with agitating device, addition accounts for enzymolysis product matter 7 times of distilled water of amount, apply pressure 90KPa, be heated to temperature as 100 DEG C, carry out simultaneously at decoction and enzyme deactivation while stirring Manage, decoction product is poured out after 4h, it is standby after cooling；
(4) it is dissolved completely in after mixing rosin and borneol in the absolute ethyl alcohol that volumetric concentration is 60%, tangerine alum is dissolved Poured into after water in the solution of the former dissolving, be uniformly mixed to obtain mixed liquor, it is standby；
(5) glycine betaine is dissolved in warm water, is put into microorganism and carries out activation 3h, leavening is made, is mixed in step (4) Liquid is poured into fermentation tank with decocting product in step (3), adds leavening, is uniformly mixed sealing, carries out fermentation process, is led to Zymotic fluid is obtained after crossing high-pressure filteration, it is standby；
(6) normal butane, isopropanol and the chloroform by isometric ratio for measuring the 1/3 of the fermentating liquid volume for accounting for step (5) mix The organic solvent formed is closed, surfactant is dissolved in organic solvent, is subsequently poured into the zymotic fluid of step (5), stirring is mixed After closing uniformly, refluxing extraction 6h is carried out in the case where temperature is 45 DEG C and nitrogen is protected, through centrifugal filtration, obtains filtered fluid, it is standby；
(7) filtered fluid of step (6) is subjected to cryogenic vacuum distillation and concentration, it is 1.0g/cm to be concentrated into density3, it is made dense Contracting cream, condensed cream carry out high pressure forced air drying and particle decentralized processing by high pressure blower, dry to dry cream moisture and are less than 5%, 50 mesh sieves are crossed, obtain the gynecological external use antibacterial powder, are packed, storage.
Embodiment 2
A kind of gynecological external use antibacterial powder, is mainly made up of following raw material：28.5 parts of the radix paeoniae rubrathe, 26 parts of setose thistle, field thistle 26 parts, 25 parts of frutus cnidii, 24 parts of the fruit of summer cypress, 21 parts of rhizoma atractylodis, 21 parts of Java brucea, 19 parts of alkanet, windproof 19 parts, 19 parts of the tuber of stemona, It is 16 parts of rosin, 13 parts of Chinese actinidia root, 13 parts of the achene of Siberian cocklebur, 11.5 parts of indigo naturalis, Chinese sumac 11.5,13 parts of Honeysuckle bine, 13 parts of schizonepeta, thin 8 parts of lotus, 8 parts of Chinese ephedra, 6.5 parts of the dried rhizome of rehmannia, 7 parts of radix scrophulariae, 5.5 parts of cloves, 5.5 parts of glycine betaine, 3.5 parts of the root bark of Chinese wolf-berry, Patrinia heterophylla 3.5 Part, 2.5 parts of cordate telosma, 2.5 parts of borneol, 2.5 parts of tangerine alum, 1.5 parts of color stabilizer, 0.4 part of surfactant, 1.3 parts of complex enzyme and 0.6 part of microorganism；
Surfactant is fatty acid sorbitan, zephiran and the lecithin mixing by waiting mass ratio Form；
Microorganism is by waiting actinomyces, streptomycete, streptococcus and the saccharomycete of mass ratio to mix；
Complex enzyme is by waiting hemicellulase, pectase and the lysozyme of mass ratio to mix.
The expectation of said ratio is prepared into gynecological external use antibacterial powder using following methods, specifically includes following steps：
(1) rosin, borneol, tangerine alum, glycine betaine, color stabilizer, surfactant, thickener, complex enzyme and microorganism will be removed Raw material in addition is soaked in potassium permanganate-salt mixed liquor that mass concentration is 0.2%, soaks 1.5h, drag for after removal of impurities is cleaned Rise and rinse and drain surface moisture, shred, it is standby；
(2) raw material after being handled in step (1) is put into enzymatic vessel, and the high pressure for applying 500MPa is located in advance to raw material Reason, is poured into enzymatic vessel after color stabilizer, complex enzyme are dissolved completely in water, adds distilled water to raw material is not crossed, stirring is mixed Close uniformly, carry out enzymolysis 2.5h at being 55 DEG C in temperature, obtain enzymolysis product, it is standby；
(3) enzymolysis product in step (2) is put into the high pressure decoction pot with agitating device, addition accounts for enzymolysis product matter 8.5 times of distilled water of amount, apply pressure 95KPa, be heated to temperature as 110 DEG C, decocted simultaneously while stirring and enzyme deactivation Handle, decoction product is poured out after 3.5h, it is standby after cooling；
(4) it is dissolved completely in after mixing rosin and borneol in the absolute ethyl alcohol that volumetric concentration is 65%, tangerine alum is dissolved Poured into after water in the solution of the former dissolving, be uniformly mixed to obtain mixed liquor, it is standby；
(5) glycine betaine is dissolved in warm water, is put into microorganism and carries out activation 4h, leavening is made, is mixed in step (4) Liquid is poured into fermentation tank with decocting product in step (3), adds leavening, is uniformly mixed sealing, carries out fermentation process, is led to Zymotic fluid is obtained after crossing high-pressure filteration, it is standby；
(6) normal butane, isopropanol and the chloroform by isometric ratio for measuring the 1/2 of the fermentating liquid volume for accounting for step (5) mix The organic solvent formed is closed, surfactant is dissolved in organic solvent, is subsequently poured into the zymotic fluid of step (5), stirring is mixed After closing uniformly, refluxing extraction 5.5h is carried out in the case where temperature is 50 DEG C and nitrogen is protected, through centrifugal filtration, obtains filtered fluid, it is standby；
(7) filtered fluid of step (6) is subjected to cryogenic vacuum distillation and concentration, it is 1.1g/cm to be concentrated into density3, it is made dense Contracting cream, condensed cream carry out high pressure forced air drying and particle decentralized processing by high pressure blower, dry to dry cream moisture and are less than 5%, 55 mesh sieves are crossed, obtain the gynecological external use antibacterial powder, are packed, storage.
Embodiment 3
A kind of gynecological external use antibacterial powder, it is characterised in that be mainly made up of following raw material：30 parts of the radix paeoniae rubrathe, setose thistle 27 parts, 27 parts of field thistle, 26 parts of frutus cnidii, 25 parts of the fruit of summer cypress, 22 parts of rhizoma atractylodis, 22 parts of Java brucea, 20 parts of alkanet, it is windproof 20 parts, 20 parts of the tuber of stemona, 17 parts of rosin, 14 parts of Chinese actinidia root, 14 parts of the achene of Siberian cocklebur, 13 parts of indigo naturalis, Chinese sumac 13,15 parts of Honeysuckle bine, schizonepeta 15 Part, 9 parts of peppermint, 9 parts of Chinese ephedra, 7 parts of the dried rhizome of rehmannia, 8 parts of radix scrophulariae, 6 parts of cloves, 6 parts of glycine betaine, 4 parts of the root bark of Chinese wolf-berry, 4 parts of Patrinia heterophylla, yesterday 0.7 part of fragrant 3 parts, 3 parts of borneol, 3 parts of tangerine alum, 2 parts of color stabilizer, 0.5 part of surfactant, 1.5 parts of complex enzyme and microorganism；
Surfactant is fatty acid sorbitan, zephiran and the lecithin mixing by waiting mass ratio Form；
Microorganism is by waiting actinomyces, streptomycete, streptococcus and the saccharomycete of mass ratio to mix；
Complex enzyme is by waiting hemicellulase, pectase and the lysozyme of mass ratio to mix.
The expectation of said ratio is prepared into gynecological external use antibacterial powder using following methods, specifically includes following steps：
(1) rosin, borneol, tangerine alum, glycine betaine, color stabilizer, surfactant, thickener, complex enzyme and microorganism will be removed Raw material in addition is soaked in potassium permanganate-salt mixed liquor that mass concentration is 0.3%, soaks 1h, pick up after removal of impurities is cleaned Rinse and drain surface moisture, shred, it is standby；
(2) raw material after being handled in step (1) is put into enzymatic vessel, and the high pressure for applying 600MPa is located in advance to raw material Reason, is poured into enzymatic vessel after color stabilizer, complex enzyme are dissolved completely in water, adds distilled water to raw material is not crossed, stirring is mixed Close uniformly, carry out enzymolysis 2h at being 60 DEG C in temperature, obtain enzymolysis product, it is standby；
(3) enzymolysis product in step (2) is put into the high pressure decoction pot with agitating device, addition accounts for enzymolysis product matter 10 times of distilled water of amount, apply pressure 100KPa, be heated to temperature as 120 DEG C, decocted simultaneously while stirring and enzyme deactivation Handle, decoction product is poured out after 3h, it is standby after cooling；
(4) it is dissolved completely in after mixing rosin, borneol, glycine betaine in the absolute ethyl alcohol that volumetric concentration is 70%, by tangerine Alum is poured into the solution of the former dissolving after being dissolved in water, is uniformly mixed to obtain mixed liquor, standby；
(5) glycine betaine is dissolved in warm water, is put into microorganism and carries out activation 5h, leavening is made, is mixed in step (4) Liquid is poured into fermentation tank with decocting product in step (3), adds leavening, is uniformly mixed sealing, carries out fermentation process, is led to Zymotic fluid is obtained after crossing high-pressure filteration, it is standby；
(6) normal butane, isopropanol and the chloroform by isometric ratio for measuring the 1/3 of the fermentating liquid volume for accounting for step (5) mix The organic solvent formed is closed, surfactant is dissolved in organic solvent, is subsequently poured into the zymotic fluid of step (5), stirring is mixed After closing uniformly, refluxing extraction 5h is carried out in the case where temperature is 55 DEG C and nitrogen is protected, through centrifugal filtration, obtains filtered fluid, it is standby；
(7) filtered fluid of step (6) is subjected to cryogenic vacuum distillation and concentration, it is 1.2g/cm3 to be concentrated into density, is made dense Contracting cream, condensed cream carry out high pressure forced air drying and particle decentralized processing by high pressure blower, dry to dry cream moisture and are less than 5%, 60 mesh sieves are crossed, obtain the gynecological external use antibacterial powder, are packed, storage.
Antibacterial powder application method：The each dosage 10g of antibacterial powder, five jin of boiling water, is poured into basin, is added fresh 1 plant of green onion, is closed the lid Son stands 5min, is cooled to 38 DEG C or so, liquid medicine is rinsed into uterus neck using expander, hip bath after rinsing 3-5 times, often It is 1-2 times.
Applicant carried out lot of experiments, now arranges part test as follows：
Comparative example 1：The raw material of gynecological external use antibacterial powder be the radix paeoniae rubrathe, setose thistle, field thistle, frutus cnidii, the fruit of summer cypress, rosin, rhizoma atractylodis, Java brucea, alkanet, the windproof and tuber of stemona, other modes are identical with the embodiment of the present invention 1.
Comparative example 2：The raw material of gynecological external use antibacterial powder be the radix paeoniae rubrathe, setose thistle, field thistle, frutus cnidii, the fruit of summer cypress, rosin, rhizoma atractylodis, Java brucea, alkanet, the windproof, tuber of stemona, color stabilizer, surfactant and microorganism, other modes and the phase of the embodiment of the present invention 1 Together.
Comparative example 3：The raw material of gynecological external use antibacterial powder is Chinese actinidia root, the achene of Siberian cocklebur, indigo naturalis, Chinese sumac, Honeysuckle bine, chaste tree Mustard, complex enzyme and microorganism, other modes are identical with the embodiment of the present invention 1.
Comparative example 4：The raw material of gynecological external use antibacterial powder is peppermint, Chinese ephedra, glycine betaine, the dried rhizome of rehmannia, radix scrophulariae, cloves, complex enzyme And microorganism, other modes are identical with the embodiment of the present invention 1.
Comparative example 5：The raw material of gynecological external use antibacterial powder be the root bark of Chinese wolf-berry, borneol, Patrinia heterophylla, cordate telosma, tangerine alum, complex enzyme and Microorganism, other modes are identical with the embodiment of the present invention 1.
The people of selection of clinical sufferer 160,8 groups are equally divided into, according to above-mentioned antibacterial powder application method, respectively using comparative example 1- Antibacterial powder made from 5 and embodiment 1-3, after one month, the focus of observation and statistics sufferer improves situation, as shown in table 1.
The focus of the sufferer of table 1 improves situation
Group Complete incidence graph/people Part alleviation/people Stabilization/people Without improvement/people
Comparative example 1 0 6 5 9
Comparative example 2 0 8 6 6
Comparative example 3 0 4 5 11
Comparative example 4 0 3 4 13
Comparative example 5 0 1 3 16
Embodiment 1 9 7 4 0
Embodiment 2 12 5 3 0
Embodiment 3 13 4 2 0
Data are shown from table 1, and after the antibacterial powder using 1-3 of the embodiment of the present invention, the focus of sufferer improves situation much More than comparative example 1-5, the sufferer for having general 50% obtains complete incidence graph focus, and illustrating the composition of raw materials of embodiments of the invention is It is the most scientific and reasonable, complemented each other between various Chinese medicines, it is mutually coordinated, effectively alleviate gynecological disease, and effect is good, the used time It is short, have no side effect.
Described above is the detailed description for the present invention preferably possible embodiments, but embodiment is not limited to this hair Bright patent claim, the equal change completed or modification change under the technical spirit suggested by all present invention, all should belong to Cover the scope of the claims in the present invention.

Claims (7)

1. a kind of gynecological external use antibacterial powder, it is characterised in that be mainly made up of following raw material：Radix paeoniae rubrathe 27-30 parts, setose thistle 25-27 parts, field thistle 25-27 parts, frutus cnidii 24-26 parts, fruit of summer cypress 23-25 parts, rhizoma atractylodis 20-22 parts, Java brucea 20-22 parts, purple Grass roots 18-20 parts, windproof 18-20 parts, tuber of stemona 18-20 parts, rosin 15-17 parts, Chinese actinidia root 12-14 parts, achene of Siberian cocklebur 12-14 parts, Indigo naturalis 10-13 parts, Chinese sumac 10-13, Honeysuckle bine 10-15 parts, schizonepeta 10-15 parts, peppermint 7-9 parts, Chinese ephedra 7-9 parts, the dried rhizome of rehmannia 6-7 parts, radix scrophulariae 6-8 parts, cloves 5-6 parts, glycine betaine 5-6 parts, root bark of Chinese wolf-berry 3-4 parts, Patrinia heterophylla 3-4 parts, cordate telosma 2-3 parts, ice Piece 2-3 parts, tangerine alum 2-3 parts, color stabilizer 1-2 parts, surfactant 0.3-0.5 parts, complex enzyme 1-1.5 parts and microorganism 0.5- 0.7 part.
2. gynecological external use antibacterial powder according to claim 1, it is characterised in that be mainly made up of following raw material： 28.5 parts of the radix paeoniae rubrathe, 26 parts of setose thistle, 26 parts of field thistle, 25 parts of frutus cnidii, 24 parts of the fruit of summer cypress, 21 parts of rhizoma atractylodis, 21 parts of Java brucea, alkanet 19 parts, windproof 19 parts, 19 parts of the tuber of stemona, 16 parts of rosin, 13 parts of Chinese actinidia root, 13 parts of the achene of Siberian cocklebur, 11.5 parts of indigo naturalis, Chinese sumac 11.5, 13 parts of Honeysuckle bine, 13 parts of schizonepeta, 8 parts of peppermint, 8 parts of Chinese ephedra, 6.5 parts of the dried rhizome of rehmannia, 7 parts of radix scrophulariae, 5.5 parts of cloves, glycine betaine 5.5 Part, 3.5 parts of the root bark of Chinese wolf-berry, 3.5 parts of Patrinia heterophylla, 2.5 parts of cordate telosma, 2.5 parts of borneol, 2.5 parts of tangerine alum, 1.5 parts of color stabilizer, surface are lived Property 0.6 part of 0.4 part of agent, 1.3 parts of complex enzyme and microorganism.
3. gynecological external use antibacterial powder according to claim 1 or 2, it is characterised in that：The surfactant be by etc. matter Fatty acid sorbitan, zephiran and the lecithin of amount ratio mix.
4. gynecological external use antibacterial powder according to claim 1 or 2, it is characterised in that：The microorganism is by waiting mass ratio Actinomyces, streptomycete, streptococcus and saccharomycete mix.
5. gynecological external use antibacterial powder according to claim 1 or 2, it is characterised in that：The complex enzyme is by waiting mass ratio Hemicellulase, pectase and lysozyme mix.
6. the preparation method of the gynecological external use antibacterial powder according to any one of claim 1-5, it is characterised in that specific bag Include following steps：
(1) will be in addition to rosin, borneol, tangerine alum, glycine betaine, color stabilizer, surfactant, thickener, complex enzyme and microorganism Raw material through removal of impurities clean after, be soaked in mass concentration be 0.1-0.3% potassium permanganate-salt mixed liquor, soak 1-2h, drag for Rise and rinse and drain surface moisture, shred, it is standby；
(2) raw material after being handled in step (1) is put into enzymatic vessel, and the high pressure for applying 400-600MPa is located in advance to raw material Reason, is poured into enzymatic vessel after color stabilizer, complex enzyme are dissolved completely in water, adds distilled water to raw material is not crossed, stirring is mixed Close uniformly, carry out enzymolysis 2-3h at being 50-60 DEG C in temperature, obtain enzymolysis product, it is standby；
(3) enzymolysis product in step (2) is put into the high pressure decoction pot with agitating device, addition accounts for enzymolysis product quality 7-10 times of distilled water, apply pressure 90-100KPa, be heated to temperature as 100-120 DEG C, carry out decocting while stirring simultaneously and Destroy the enzyme treatment, decoction product is poured out after 3-4h, it is standby after cooling；
(4) it is dissolved completely in after mixing rosin and borneol in the absolute ethyl alcohol that volumetric concentration is 60-70%, tangerine alum is dissolved in Poured into after water in the solution of the former dissolving, be uniformly mixed to obtain mixed liquor, it is standby；
(5) glycine betaine is dissolved in warm water, is put into microorganism and carries out activation 3-5h, leavening is made, mixed liquor in step (4) Poured into decocting product in step (3) in fermentation tank, add leavening, be uniformly mixed, sealed, carry out fermentation process, led to Zymotic fluid is obtained after crossing high-pressure filteration, it is standby；
(6) 1/3-1/2 for the fermentating liquid volume for accounting for step (5) organic solvent is measured, surfactant is dissolved in organic solvent In, it is subsequently poured into the zymotic fluid of step (5), after being uniformly mixed, is returned in the case where temperature is 45-55 DEG C and nitrogen is protected Stream extraction 5-6h, through centrifugal filtration, obtains filtered fluid, standby；
(7) filtered fluid of step (6) is subjected to cryogenic vacuum distillation and concentration, it is 1.0-1.2g/cm to be concentrated into density3, concentration is made Cream, condensed cream carry out high pressure forced air drying and particle decentralized processing by high pressure blower, dry to dry cream moisture and are less than 5%, 50-60 mesh sieves are crossed, obtain the gynecological external use antibacterial powder, are packed, storage.
7. the preparation method of gynecological external use antibacterial powder according to claim 6, it is characterised in that：Step has described in (6) Solvent is mixed by normal butane, isopropanol and the chloroform of isometric ratio.
CN201710654288.8A 2017-08-03 2017-08-03 A kind of gynecological external use antibacterial powder and preparation method thereof Pending CN107375799A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109731085A (en) * 2019-03-18 2019-05-10 福建天斯顿生物科技有限公司 A kind of external wash liquid product and preparation method thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104116981A (en) * 2014-07-29 2014-10-29 李献国 Traditional Chinese medicine composition for treating gynecopathy and preparation method of traditional Chinese medicine composition as well as medical panty liner applying traditional Chinese medicine composition and preparation method of medical panty liner

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104116981A (en) * 2014-07-29 2014-10-29 李献国 Traditional Chinese medicine composition for treating gynecopathy and preparation method of traditional Chinese medicine composition as well as medical panty liner applying traditional Chinese medicine composition and preparation method of medical panty liner

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109731085A (en) * 2019-03-18 2019-05-10 福建天斯顿生物科技有限公司 A kind of external wash liquid product and preparation method thereof
CN109731085B (en) * 2019-03-18 2021-06-29 福建天斯顿生物科技有限公司 External lotion product and preparation method thereof

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Application publication date: 20171124