CN107375700A - A kind of herbal composition preparation with prevention and treatment male infertility infertility - Google Patents
A kind of herbal composition preparation with prevention and treatment male infertility infertility Download PDFInfo
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- CN107375700A CN107375700A CN201710487678.0A CN201710487678A CN107375700A CN 107375700 A CN107375700 A CN 107375700A CN 201710487678 A CN201710487678 A CN 201710487678A CN 107375700 A CN107375700 A CN 107375700A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/68—Plantaginaceae (Plantain Family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
The invention provides a kind of herbal composition preparation with prevention and treatment male infertility infertility, this herbal medicine compound preparation is the blue root of triangle, An Desi water alpine rush or palm-bark rain cape seeds, seta black beans seed, bashfully grass seed, Arabic gum natural gum, astragalus root, plantain seed kind skin, kapok glue, Tongkat Ali root passes through ethanol, methanol, acetone, flooding concentration forms, verified through human trial, the herbal composition preparation can be effectively improved the male infertility infertile patients general level of the health, improve semen volume, sperm concentration and sperm motility are horizontal, significantly improve male testical hormone and hormone hormonal readiness, therefore this herbal medicine compound preparation is to treat the sterile medicine of male infertility or concerned foodstuff with potential value with exploitation.
Description
Technical field
The invention belongs to field of plant extraction, there is prevention and treatment male infertility infertility in particular to a kind of
Herbal composition preparation.
Background technology
In mankind's infertility, male sterility reaches 50%, and in the patient of male infertility infertility, pathogenic factor is not
Bright reached sum 40%~50%, wherein about 8% patient seeks herbtherapy.Cause the original of male infertility infertility
Many because having, the different causes of disease needs to take different therapeutic modalities.Male sterility can find multinomial in physiopathology inspection
Biochemical indicator reduces, the especially reduction of sperm.
In order to improve male's sexual, multiple therapy methods are employed, for example, spiritual scholar or psychologist pass through psychology
Therapy, patient is allowed to establish confidence so as to be treated；Can also be solved by surgical device or operation implantable penile etc.；Male lotus
You cover hormone therapy especially testosterone, or other specific drugs can be used to maintain the erection of male, desire level and climax.
To supplement or correct other treatment methods of the Clinics and Practices of male infertility infertility also in continuous research, for example, people
Human chorionic gonadtropin treats (hCG), hormone hormone therapy, (IVF) in vitro fertilization etc..
At present during male infertility infertility is treated, many drawbacks are inevitable, such as medical expense is high, surgery hand
Situation is complicated in art and has the risk of operative failure, drug therapy can cause headache, dizziness, eye-blurred, blush, have a stuffy nose,
Penis priapism etc..Although modern treatment method is advanced, effect is good, and cheap medicine, which still needs, to be ground
Hair.Centuries, countries in the world people seek the solution method of male infertility infertility using endemic plant always.Therefore plant source
Herbal medicine be selected to supplementary therapy male infertility infertility always, and it improves male sexual desire and hoped and the effect of sexuality
It is proved to.
Now, India herbal medicine is received because its clinical effectiveness is obvious, manufacturing price is cheap by people.Many India herbal medicines
There is excitability ability, the blue root of its intermediate cam, An Desi water alpine rush or palm-bark rain capes seed, bashfully seta black beans seed, grass seed, Ah
Draw primary gum glue, astragalus root, plantain seed kind skin, kapok glue, Tongkat Ali root positive effect.In zoopery, study
Show that it has the function that to stimulate sexual function, but do not carried out also in human trial, it is therefore desirable to do human trial as grass
Medicine preparation for treating male's sexual function provides theoretical foundation, to research and develop cheap natural products medicine of fine quality replace price it is high,
Synthetic drug more than side effect is significant.
The content of the invention
In view of existing research deficiency, it is an object of the invention to by the blue root of triangle, An Desi water alpine rush or palm-bark rain capes seed, seta
Black beans seed, bashfully grass seed, Arabic gum natural gum, astragalus root, plantain seed kind skin, kapok natural gum, Tongkat Ali root compound grass
Medicine preparation carries out human trial, there is provided a kind of compound herbal medicinal product for preventing and treating male sexual disfunction and its application.
The technical scheme of implementation of the present invention is：A kind of herbal composition system with prevention and treatment male infertility infertility
Agent, be the methanol of herbal medicine, ethanol, acetone, water extract compound preparation prepare treat in male infertility acarpous medicine should
With.
What described herbal composition extract was prepared by the following method：Collect the blue root of triangle, An Desi water alpine rush or palm-bark rain cape kinds
Son, bashfully seta black beans seed, grass seed, Arabic gum natural gum, astragalus root, plantain seed kind skin, kapok glue, Tongkat Ali root,
Dried after cleaning impurity elimination, beat powder, take 15~30g dry powder to be put in the second equipped with 30~100ml successively after being ground under protection of liquid nitrogen
Alcohol, methanol, acetone, water 250ml triangular flasks in, in mixing speed 280rpm, Extracting temperature is 15~50 DEG C, lucifuge condition
16~20h of lower extraction, extract solution filtering, collect after filtrate is concentrated by evaporation in 40 DEG C and freeze, -80 DEG C save backup.
The medicine of described treatment male infertility infertility includes said extracted thing and pharmaceutically acceptable carrier or normal
Advise non-staple foodstuff, such as capsule, tablet, beverage, oral liquid, function meals etc..
[beneficial effect]
Compared with prior art, the present invention has following beneficial technique effect：
This herbal medicine compound preparation has obvious effect for male infertility sterile treatment, it is possible to increase sperm is dense in semen
Degree, sperm motility, sperm power and semen volume and the compound preparation can increase the content of male hormone in blood, because
This, the herbal composition preparation has potential value to exploitation treatment male sexual disfunction, the medicine without defective ejaculation essence.
Embodiment
Below in conjunction with example, to embodiment provided by the invention, details are as follows：
38 male infertility infertile patients are chosen, the age, sperm count was 5~20 × 10 in seminal fluid between 22~40 years old6Individual/
Ml, sperm motility is in the range of 10~25%, and the sperm to travel forward is less than 15%, and sperm morphology natural rate of interest is less than 70%.Institute
There is the equal unsoundness spouse of patient.
38 male patients are randomly divided into two groups, one group is control group, and number is 15 people；One group is experimental group, number
For 23 people.Control group patient is taken containing 250mg Cebo-Capses, and experimental group is then taken and extracted containing 250mg compounds herbal medicine
The capsule of thing, is administered three times a day, and takes 90d.
Compound herbal medicinal product formula：The blue root of triangle, An Desi water alpine rush or palm-bark rain capes seed, seta black beans seed, bashfully grass seed, Ah
Primary gum glue, astragalus root, plantain seed kind skin, kapok glue, Tongkat Ali root extract ratio in compounding is drawn to have in 10-30% aobvious
Effect is write, the implementation case chooses 1:1:1:1:1:1:1:1:8 ratio is made after being compounded containing 250mg active ingredients
Capsule uses.
Embodiment 1：
38 male patient's body mass index are determined, and calculate indices average value, its result is as shown in table 1：
Table 1：Male patient's body mass index
Embodiment 2：
Two groups of male patient's seminal fluid are gathered after administration 0,60,90d respectively, carry out Semen routione index subjet inspection.Its seminal fluid
Measure result such as table 2：
Table 2：Male patient's semen volume inspection after administration
As shown in Table 2, in Sperm recovery, semen volume >=2ml and seminal fluid are milky, semifluid shape, are liquefied in 30min
To be normal, experimental group male patient semen volume showed increased compared with control group after herbal composition preparation is taken, take 60 days
Semen volume recovers normal afterwards, and with the increased significant effect of extension semen volume of Time of Administration.
Embodiment 3：
Two groups of male patient's seminal fluid are gathered after administration 0,60,90d respectively, carry out Semen routione index subjet inspection.Its sperm
Concentration results such as table 3：
Table 3：Male patient's sperm concentration inspection after administration
As shown in Table 3, in Sperm recovery, eupyrene sperm density ＞ 20 × 106Individual/ml, taken with placebo contrast
For the male patient of herbal composition preparation after 60d is taken, sperm concentration recovers normal, and as medicine time extends sperm concentration
Increase more.
Embodiment 4：
Two groups of male patient's seminal fluid are gathered after administration 0,60,90d respectively, carry out Semen routione index subjet inspection.Its sperm
Vigor result such as table 4：
Table 4：Male patient's sperm motility inspection after administration
From 4, in Sperm recovery, eupyrene sperm vigor a levels are more than 25%, take herbal medicine with placebo contrast and answer
For the male patient of square preparation after 60d is taken, sperm motility recovers normal, and with medicine time extend sperm motility increase compared with
It is more.
Embodiment 5：
Two groups of male patient's blood are gathered after administration 0,90d respectively, carry out plasma testosterone inspection.Its plasma testosterone
As a result such as table 5：
Table 5：Male patient's plasma testosterone inspection after administration
As shown in Table 5, in plasma testosterone inspection, the male patient that herbal composition preparation is taken with placebo contrast exists
After taking 90d, testosterone concentration is improved in blood plasma.
Embodiment 6：
Two groups of male patient's blood are gathered after administration 0,90d respectively, carry out plasma hormone hormone inspection.Its plasma hormone
Hormone result such as table 6：
Table 6：Male patient's plasma hormone hormone inspection after administration
As shown in Table 6, in the inspection of male hormones hormone, the male patient of herbal composition preparation is taken with placebo contrast
After 90d is taken, hormone hormonal readiness is improved in blood plasma.
By understanding that herbal composition preparation can be effectively improved the male infertility infertile patients general level of the health in embodiment 1-6, carry
High semen volume, sperm concentration and sperm motility are horizontal, significantly improve male testical hormone and hormone hormonal readiness, therefore book on Chinese herbal medicine
Medicine compound preparation has exploitation for the medicine for the treatment of male infertility infertility or the potential value of concerned foodstuff.
Claims (3)
- A kind of 1. herbal composition preparation with prevention and treatment male infertility infertility.
- 2. a kind of herbal composition preparation with prevention and treatment male infertility infertility according to claim 1, its feature It is：Herbal composition ethanol, methanol, acetone, water extract are prepared by following methods, collect the blue root of triangle, An De This water alpine rush or palm-bark rain cape seed, bashfully seta black beans seed, grass seed, Arabic gum natural gum, astragalus root, plantain seed kind skin, kapok glue, east leather Ali's root, dried after cleaning impurity elimination, beat powder, respectively at ethanol, methanol, acetone, aqueous extract mistake after being ground under protection of liquid nitrogen Filter, collect after filtrate is concentrated by evaporation in 40 DEG C and freeze, subzero 80 DEG C save backup.
- 3. a kind of herbal composition preparation with prevention and treatment male infertility infertility according to claim 1, its feature Being the medicine of described treatment male infertility infertility includes said extracted thing and pharmaceutically acceptable carrier or conventional secondary Food.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710487678.0A CN107375700B (en) | 2017-06-23 | 2017-06-23 | A herbal compound preparation for preventing and treating male infertility |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710487678.0A CN107375700B (en) | 2017-06-23 | 2017-06-23 | A herbal compound preparation for preventing and treating male infertility |
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| Publication Number | Publication Date |
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| CN107375700A true CN107375700A (en) | 2017-11-24 |
| CN107375700B CN107375700B (en) | 2020-09-29 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111329943A (en) * | 2018-12-19 | 2020-06-26 | 山东理工大学 | A compound herbal preparation with antihyperglycemic and antioxidant effects for treating diabetes |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008018785A1 (en) * | 2006-08-07 | 2008-02-14 | Universiti Sains Malaysia | Polar organic extract of eurycoma longifolia |
| CN102091280A (en) * | 2011-01-18 | 2011-06-15 | 赵谷明 | Pure traditional Chinese medicine preparation for treating infertility and preparation method thereof |
-
2017
- 2017-06-23 CN CN201710487678.0A patent/CN107375700B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008018785A1 (en) * | 2006-08-07 | 2008-02-14 | Universiti Sains Malaysia | Polar organic extract of eurycoma longifolia |
| CN102091280A (en) * | 2011-01-18 | 2011-06-15 | 赵谷明 | Pure traditional Chinese medicine preparation for treating infertility and preparation method thereof |
Non-Patent Citations (4)
| Title |
|---|
| C. BHARGAVA等: "Effect of Bombax ceiba L. on spermatogenesis, sexual behaviour and erectile function in male rats", 《ANDROLOGIA》 * |
| EDEM EDEM EKPENYONG: "The impact of Mimosa pudica on the Histoarchitecture of hypothalamic-pituitary-testicular axis in cadmiumtreated rats", 《WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES》 * |
| J. S. FEDAIL等: "Gum arabic improves semen quality and oxidative stress capacity in alloxan induced diabetes rats", 《ASIAN PACIFIC JOURNAL OF REPRODUCTION》 * |
| ROHIT DHUMAL等: "Efficacy and safety of a herbo-mineral ayurvedic formulation ‘Afrodet Plus®’ in male rats", 《JOURNAL OF AYURVEDA & INTEGRATIVE MEDICINE》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111329943A (en) * | 2018-12-19 | 2020-06-26 | 山东理工大学 | A compound herbal preparation with antihyperglycemic and antioxidant effects for treating diabetes |
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