CN107375659A

CN107375659A - Hydropericardium pharmaceutical composition and preparation method thereof

Info

Publication number: CN107375659A
Application number: CN201710555412.5A
Authority: CN
Inventors: 于婧; 于筱水; 柳洋; 刘广焕
Original assignee: Qingdao Central Hospital
Current assignee: Qingdao Central Hospital
Priority date: 2017-07-10
Filing date: 2017-07-10
Publication date: 2017-11-24

Abstract

The invention belongs to heart function section to check postoperative adjuvant therapy technical field, more particularly to a kind of hydropericardium pharmaceutical composition and preparation method thereof.Wherein endo-medicine is made up of the component of following mass fraction：46 parts of alangium, 35 parts of the Chinese bulbul, 35 parts of radix scutellariae, 68 parts of FLOS CHRYSANTHEMI from Hangzhou of China, yellow grass spend 35 parts, 46 parts of antelope's horn, 46 parts of viola japonica, 46 parts of Verbena officinalis, 12 parts of indigo naturalis, 46 parts of mock-strawberry, 35 parts of wilsonii, 46 parts of rhodiola root, 46 parts of lily, 35 parts of chorion ovi, 35 parts of oyster；External used medicine is made up of the component of following mass fraction：White 46 parts of cudweed of the back of the body, 46 parts of pilosella-leaved drymoglossum herb, 35 parts of marginate American agave leaf, 35 parts of the dried rhizome of rehmannia, 46 parts of cornu bubali, 58 parts of soybean, 35 parts of thorn youth fruit, 35 parts of Herba Andrographitis, 46 parts of Poria cocos, 46 parts of Japanese ardisia.The present invention holds back wound using oral traditional Chinese medicine preparation and promotes wound healing, while wound caused by using checking imports treatment decoction, promotes rehabilitation, achieves the effect of good.

Description

Hydropericardium pharmaceutical composition and preparation method thereof

Technical field

The invention belongs to heart function section treatment technology field, more particularly to a kind of hydropericardium pharmaceutical composition and its system Preparation Method.

Background technology

Heart function examination room refers to the Medical Treatment Room that test cardiac function is specifically used in hospital, and some heart functions are typically deposited in the inside Tester, the main function of checking heart function the following aspects：1st, Holter, 2, exercise electrocardiogram, 3, esophagus adjusts Fight, 4, VLP, 5, vactocardiography, 6, heart function detection.Be by various inspection methods measure heart contractile function, The inspection section office of diastolic function, blood-pumping function and vegetative nerve regulatory function etc..Cardiac inspection be specifically divided into it is traumatic and The major class of non-invasive two, there is traumatic examination to include heart function examination by centesis, angiocardiography, the inspection of heart cathetrization haemodynamics Dye dilution method, electromagnetic flowmeter method etc. are surveyed, advantage is that data are accurate, reliable；Shortcoming is that have wound, and equipment and technical conditions will Ask high.Non-invasive cardiac inspection includes electrocardiogram, caardiophonogram, carotic pulse graph, apexcardiography, and this 4 are collectively referred to as the heart Electromechanical figure, in addition with echocardiogram, impedance cardiogram, pareordia impedance diagram and various models lead physiograph etc. more, excellent Point is hurtless measure, no pain, simple and convenient, accurate rapid, and shortcoming is not as good as there is traumatic heart function accurate.

Hydropericardium inspection needs to carry out to puncture often extracts hydrops, patient insufficiency of primordial QI itself, wound site recover it is slow, Easy infection, very big pain is added to patient, be unfavorable for later stage rehabilitation.

The content of the invention

Present invention solves the technical problem that it is that hydropericardium inspection needs puncture to extract hydrops often, patient is first in itself Unsaturated vapor, wound site recover slow, easy infection, very big pain are added to patient, is unfavorable for later stage rehabilitation.The present invention uses Oral traditional Chinese medicine preparation holds back wound and promotes wound healing, while wound caused by using checking imports treatment decoction, promotes rehabilitation, Achieve the effect of good.

To solve the above problems, the present invention provides a kind of hydropericardium pharmaceutical composition, wherein endo-medicine is by following The component composition of mass fraction：Alangium 4-6 parts, Chinese bulbul 3-5 parts, radix scutellariae 3-5 parts, FLOS CHRYSANTHEMI from Hangzhou of China 6-8 parts, yellow grass flower 3-5 parts, Antelope's horn 4-6 parts, viola japonica 4-6 parts, Verbena officinalis 4-6 parts, indigo naturalis 1-2 parts, mock-strawberry 4-6 parts, wilsonii 3-5 parts, rhodiola root 4-6 Part, lily 4-6 parts, chorion ovi 3-5 parts, oyster 3-5 parts.

Further optimization, is made up of the component of following mass fraction：5 parts of alangium, 4 parts of the Chinese bulbul, 4 parts of radix scutellariae, Hang Ju Spend 7 parts, yellow grass spend 4 parts, 5 parts of antelope's horn, 5 parts of viola japonica, 5 parts of Verbena officinalis, 1 part of indigo naturalis, 5 parts of mock-strawberry, 4 parts of wilsonii, red scape It 5 parts, 5 parts of lily, 4 parts of chorion ovi, 4 parts of oyster.

External used medicine is made up of the component of following mass fraction：White back of the body cudweed 4-6 parts, pilosella-leaved drymoglossum herb 4-6 parts, golden-rimmed imperial tongue It is blue 3-5 parts, dried rhizome of rehmannia 3-5 parts, cornu bubali 4-6 parts, soybean 5-8 parts, thorn youth fruit 3-5 parts, Herba Andrographitis 3-5 parts, Poria cocos 4-6 parts, flat Ground wood 4-6 parts.

Further optimization, is made up of the component of following mass fraction：White 5 parts of cudweed of the back of the body, 5 parts of pilosella-leaved drymoglossum herb, golden-rimmed imperial tongue Blue 4 parts, 4 parts of the dried rhizome of rehmannia, 5 parts of cornu bubali, 7 parts of soybean, 4 parts of thorn youth fruit, 4 parts of Herba Andrographitis, 5 parts of Poria cocos, 5 parts of Japanese ardisia.

The preparation method of endo-medicine comprises the steps of：

(1) bulk drug is weighed by weight to add water to cook twice, every time plus 4 times are measured water, for the first time decoction 2 hours, and second It is secondary to decoct 1 hour, merging filtrate, after filtering, it is dried to fine powder；

(2) fine powder in step (1) is added into anhydrous grape Icing Sugar to be well mixed；

(3) above-mentioned mixed-powder is put into capsule filling machine to be filled, that is, obtains every 0.4-0.6 grams of capsule.

The preparation method of external used medicine comprises the steps of：

(1) weigh Chinese medicine material by above-mentioned weight ratio, prior to 4-10 DEG C under the conditions of refrigerate 12-24h, then at -10~-18 DEG C Lower freezing 10-20h is standby；After freezing, volumetric expansion when being frozen using hydrone, the eucaryotic cell structure of Chinese medicine is directly destroyed, is carried High cellular damage rate, laid the first stone for the microwave bulking of next step.

(2) temperature in microwave storehouse is set as 110-130 DEG C, microwave storehouse is preheated, and then puts into 1-2kg steps (1) Chinese medicine material after freezing processing, regulation microwave power are 450-600w, and operation 120-180s carries out microwave bulking；Then by temperature Degree is adjusted to 40-80 DEG C, microwave power 90-120w, dries 6-9min；It is swollen that Chinese medicine after freezing is directly carried out to microwave To change, the strength for being directly changed into the distillation of gas moment from ice using hydrone completes puffing process, does not then have to take out Chinese medicine, Directly be dried using microwave, in dry process open stirring, Chinese medicine during stirring uniform drying and because Microwave bulking, which is dried, to become fragile, and disintegrating slag is broken into naturally in whipping process, beneficial to the crushing in later stage.

(3) Chinese medicine after step (2) processing is put into ball mill and crushed；Further crush can cause medicinal material powder End is homogeneous, and various active ingredients further separate out, beneficial to importing.

(4) the addition protease of the Chinese medicine material after crushing is weighed in proportion to be digested.Bioprotein after enzymolysis divides greatly Son has been cut into small molecular protein and polypeptide, is easy to penetrate epidermis, is worked into body fluid.

(5) according to 1:100~1:500 solid-liquid ratio soaks ultrafiltration after 12~24h in ethanol.Pole after ethanol extracts Property composition be readily dissolved in body fluid, be oriented to target location, it is quick；Macromolecular is further filtered in ultrafiltration, and what is left is that biology is small Molecule, work faster.

(6) liquid after ultrafiltration is sealed after microwave disinfection.Microwave disinfection avoid high temperature sterilization to effectively into The destruction divided, drug effect are more preferable.

Further, stage drying is used after step (2) microwave bulking, i.e., it is 70-80 DEG C to adjust temperature first, work( Rate 110-120w, dry 2-3min；Then it is 50-70 DEG C, power 100-110w to adjust temperature, dries 2-3min；Finally adjust Temperature is 40-50 DEG C, power 90-100w, dries 2-3min.

Further, the pulverization conditions of the step (3) are to shut down 3min, then anti-mill after 15min is just being ground using ball mill 3min is shut down after 15min, so repeatedly 2 times.

Further, the protease in the step (4) is alkali protease, neutral proteinase, papain or pancreas One or more in protease.It is demonstrated experimentally that take the importing liquid best results after several protease hydrolyzeds of the above.

Further, the molecular weight that milipore filter retains in the step (5) is 15000-20000.It is demonstrated experimentally that molecular weight It is to retain the most molecular weight of active ingredient for 15000-20000, and it is rapid-action, effect is good.

Further, step (6) the microwave disinfection condition is 70 DEG C -105 DEG C, second time 90-180.It can kill Farthest retain active ingredient on the basis of microorganism not to be destroyed.

Application method：Take endo-medicine immediately after puncturing pericardial effusion, punctured after taking endo-medicine half an hour Place applies the cotton yarn for being soaked with decoction, is removed after half an hour, and once, continuous one week treatment is a course for the treatment of for daily treatment afterwards.

Toxicity Analysis：

Alangium：It is clearing heat and detoxicating, promoting blood circulation to remove blood stasis.Energy dispelling wind and eliminating dampness, relaxing tendons and activating collaterals, blood stasis removing analgesic, for arthralgia pain due to rheumatism, four Acroanesthesia, traumatic injury；Leaf is used for injury and bone fracture, outer knife wound bleeding；Flower is used for intermittent headache pain and fullness and oppression of chest and abdomen.

The Chinese bulbul：Bitter, it is cold in nature；Return stomach, large intestine channel.With clearing heat and detoxicating, remove heat from the blood and relieve diarrhea, the effect of removing dampness and destroying parasites； Cure mainly heat toxin dysentery, nosebleed epistaxis, bleeding, under band, pruritus vulvae, ulcerative carbuncle, scrofula.

Radix scutellariae：Hardship, tremble with fear.Return lung, courage, spleen, large intestine, small intestinl channel.There is heat-clearing and damp-drying drug, cool blood is antiabortive, detoxicating functions.Cure mainly temperature Pyreticosis, the infection of the upper respiratory tract, cough with lung heat, neonatal jaundice caused by dampness-heat, pneumonia, dysentery, hemoptysis, hot eyes, fetal irritability, hypertension, carbuncle swells The diseases such as furuncle sore.

FLOS CHRYSANTHEMI from Hangzhou of China：Sweet cold nature, return lung, Liver Channel, can dispelling wind and heat from the body, flat liver improving eyesight is clearing heat and detoxicating；Control headache mesh It is dizzy, shed tears, regulating blood condition, rheumatism, integumentary musculature necrosis etc., also with regulating the qi flowing in the channels, beard and hair it is not white, prolong life the effect of.

Yellow grass is spent：Herba Corydalis aduncae.Hardship, it is cool；Enter lung, stomach two passes through.Effect is clearing heat and detoxicating, cooling blood and hemostasis, clearing liver cholagogic, only Bitterly；Nose furuncle caused by curing mainly lung heat, stomach fire, abscess of throat, gums redness, aphthae, blood-heat bleeding go out blood trouble, as nosebleed epistaxis, The diseases such as bleeding gums.

Antelope's horn：Effect is calming the liver to stop the wind, and heat-clearing is relieving convulsion, removing toxic substances.Control pyreticosis coma convulsion to write from memory, delirious speech is gone mad；Dizziness of having a headache, shy Epilepsy is twitched, conjunctivitis.For high fever frightened epilepsy, coma convulsion is fainted, and eclampsia twitch, epilepsy is gone mad, dizziness of having a headache, cataract, temperature Poison hair spot, carbuncle sore tumefacting virus.

Viola japonica：Taste bitter, acrid, cold.The thoughts of returning home, lung channel.With clearing heat and detoxicating, cool blood detumescence, the effect of clearing heat and promoting diuresis, cure mainly Furunculosis, carbuncle swells, scrofula, jaundice, dysentery, diarrhoea, hot eyes, larynx numbness, venomous snake bite.

Verbena officinalis：It is cool in nature, bitter；Enter liver, the spleen channel.Function is clearing heat and detoxicating, promoting blood circulation to remove blood stasis, inducing diuresis for removing edema；Cure mainly diseases caused by external factors hair Heat, jaundice with damp-heat pathogen, oedema, dysentery, malaria, diphtheria, larynx numbness, gonorrhoea, Amenorrhea, abdominal mass, carbuncle sore tumefacting virus, noma.

Indigo naturalis：Nature and flavor are salty-cold, Return liver, lung, stomach.There is clearing heat and detoxicating, cool blood to dissipate the effect such as swollen, clearing liver-fire, arresting convulsion.It is main Control warm disease excess heat, macula, spit blood, spitting of blood, pharyngalgia, aphtha, pediatric epilepsy scared, sore swells, erysipelas, eczema, Cuo carbuncles, mumps, snakeworm stings Wound etc..Modern pharmacological research shows that indigo naturalis has antitumor, antibacterium and dermatophyte, enhancing is immune, treats ulcer, liver protection etc. Effect.

Mock-strawberry：It is sweet, bitter, tremble with fear；Return lung, liver, large intestine channel.Function heat-clearing, cool blood, subside a swelling, removing toxic substances；Control pyreticosis, frightened epilepsy, cough Cough, spit blood, abscess of throat, dysentery, carbuncle swells, furunculosis, snake bite and insect sting, burn.

Wilsonii：Qi-tonifying drug, the effect of being helped the weak with qi-restoratives, it can prevent or treat the disease having a delicate constitution, nourishing is strong It is strong, promote longevity.Function：Modern medicine research has shown that the action character of wilsonii and ginseng are essentially identical, has regulation body Disorder, it is allowed to tend to normal function, there is good antifatigue effect, it is notable compared with ginseng, and can significantly improve resist oxygen lack energy Power.

Rhodiola root：Can tonifying Qi clearing lung-heat, intelligence development nourishing heart, sweetness and bitterness puts down.Return lung the heart channel of Hang-Shaoyin.Qi and activate blood circulation, promotes blood circulation and relievings asthma.For gas Empty blood stasis, chest impediment and cardialgia, hemiplegia, burnout asthma.

Lily：Bitter, cold nature.Enter the heart, lung channel.Yin nourishing and lung moistening, clearing away the heart fire and tranquillizing.For yin chronic cough, blood-stained sputum, Dysphoria palpitates with fear, insomnia and dreamful sleep are absent-minded.With Yin nourishing and lung moistening cough-relieving effect, for the cough caused by dryness-heat of Lung-Yin deficiency, such as all sorts of flowers Cream.Control chronic cough of deficiency lung, overstrain cough spitting of blood, such as baihe gujin decoction.With clearing away the heart fire and tranquillizing effect, unclear for pyreticosis waste heat, dysphoria is shied Throb with fear, insomnia and dreamful sleep etc..

Chorion ovi：It is sweet, it is light, it is mild-natured；Returns spleen, stomach, lung channel.Function nourishiing yin to clear away the lung-heat, sore, disappear screen, synthetism；Cure mainly outer cough Asthma, pharyngalgia aphonia, scrofula, unhealing ulcer, mesh life ocular, vertigo, trauma fracture.

Oyster：Transquilization with heavy material, checking exuberance of yang tonifying yin, softening and resolving hard mass, convergence is astringent or styptic treatment for spontaneous sweating, for insomnia of palpitating with fear, dizziness and tinnitus, scrofula phlegm Band is collapsed in core, note of the ancient Chinese lump in the abdomen lump in the abdomen, spontaneous sweating, seminal emission, pantothenic acid of having a stomachache.Calcined oyster shell convergence is astringent or styptic treatment for spontaneous sweating, and for spontaneous sweating, band is collapsed in seminal emission, Stomachache acid regurgitation.

White back of the body cudweed：Nature and flavor are sweet, cool.Effect clearing heat and promoting diuresis, hemostasia and promoting granulation, removing toxicity for detumescence；Flu is cured mainly, is coughed, head Bitterly, sore-throat, cataract, bladder damp-heat, urine leaching pain, vaginal discharge diseases, carbuncle swells, furunculosis.

Pilosella-leaved drymoglossum herb：It is sweet, it is light, it is micro- cool；Channel tropism liver, lung channel.Effect is clearing heat and detoxicating, dispersing swelling and dissipating binds, hemostasis.

Marginate American agave leaf：It is mild-natured, sweet, micro-pungent.Effect moistens the lung and relieve the cough, cooling blood and hemostasis, clearing heat and detoxicating.

The dried rhizome of rehmannia：Clearing heat and promoting fluid, after cool, hemostasis；For hot blast impairment of yin, the deep red polydipsia of tongue, spot dermexanthesis, haematemesis, bleeding from five sense organs or subcutaneous tissue, throat Swelling and pain.Radix rehmanniae recen clearing heat and cooling blood, yin-nourishing, promotes the production of body fluid；For pyreticosis polydipsia, spot dermexanthesis, yin asthenia generating intrinsic heat, haematemesis, bleeding from five sense organs or subcutaneous tissue, glycosuria Disease, catarrhal jaundice.

Cornu bubali：Hardship, tremble with fear；The thoughts of returning home, Liver Channel.Effect clearing heat and cooling blood, detoxify, arresting convulsion；Cure mainly warm disease high fever, coma and delirium, Spot dermexanthesis, hematemesis and epistaxis, infantile convulsion are demented.

Soybean：It is sweet, mild-natured, enter spleen, large intestine channel, in having invigorating the spleen wide, the effect of moisturizing the water that disappears, clearing heat and detoxicating, QI invigorating； Cure mainly the thin thin, gestosis of infantile malnutrition due to digestive disturbances or intestinalparasites rush down dysentery, abdominal distension, sore and toxic, traumatism and bleeding etc..Soya bean can also anti-inflammation, to pharyngitis, knot Film inflammation, stomatitis, bacillary dysentery, enteritis are effective.Immunity of organism can be strengthened, vascular sclerosis is prevented, promote skeleton development, resistance iron deficiency Property anaemia, being capable of anti-oxidant and anti-aging effect.

Pierce youth fruit：Hardship, it is pungent, it is mild-natured.Function is clearing heat and detoxicating, anti-inflammatory analgetic；Icteric hepatitis is cured mainly, is had a stomachache, rheumatoid arthrosis Bitterly, acute conjunctivitis, sphagitis, periodontitis, lymphnoditis.

Herba Andrographitis：Bitter, it is cold in nature.The thoughts of returning home, lung, large intestine, bladder warp.It is clearing heat and detoxicating, cool blood, detumescence, eliminating dampness.Heat-clearing solution Poison, cool blood detumescence.Control acute bacillary dysentery, gastroenteritis, flu, epidemic meningitis, tracheitis, pneumonia, pertussis, pulmonary tuberculosis, lung abscess, gall-bladder Inflammation, hypertension, nosebleed epistaxis, oropharynx swelling and pain, boil carbuncle swells, scald, venomous snake bite.

Poria cocos：With anti-oxidant, anti-aging, increase immunity, the effect of raising brain cell activity.Poria cocos has stronger Diuresis, ephritis, heart failure oedema can be treated.There is sedation in addition, it is effective to neurasthenia.It is lightly seasoned mild-natured, it is apt to QI invigorating Blood-nourishing, antitoxic heart-soothing and sedative, internal heat anticance；Mild in medicine property and, for dampness removing without hindering healthy tendency, contained pachymic acid has strengthen immunity, anti-swollen Knurl and the effect of calmness, hypoglycemic etc.；Can be relaxed gastrointestinal smooth muscle, gastric acid secretion inhibiting, prevent necrosis of liver cells, antibacterial And other effects.

Japanese ardisia：It is mild-natured, acrid flavour, slight bitter.Return lung, Liver Channel.The effect of with preventing phlegm from forming and stopping coughing, dampness removing, promoting blood circulation.To golden yellow Staphylococcus, streptococcus pneumonia have inhibitory action.

The Chinese medical extract sheerly Chinese medicine preparation of the present invention, by endo-medicine combination external used medicine synergy, for Puncturing pericardial effusion postoperation recovery greatly facilitates effect, using after medicine of the present invention without complication, and hydropericardium situation There is different degrees of improvement.Wherein, alangium, the Chinese bulbul, radix scutellariae, FLOS CHRYSANTHEMI from Hangzhou of China, yellow grass flower have the function that clearing heat and promoting diuresis, can Alleviate the situation of deficiency of heart-QI；Antelope's horn, viola japonica, Verbena officinalis, indigo naturalis, mock-strawberry have removing toxicity for detumescence effect, are advantageous to wound Healing；Wilsonii, rhodiola root, lily, chorion ovi, oyster have the function that the moon is educated in tonifying Qi, are rebuild one's physical constitution beneficial to patient；The white back of the body Cudweed, pilosella-leaved drymoglossum herb, marginate American agave leaf, the dried rhizome of rehmannia, cornu bubali have the function that blood-stanching and blood-cooling, and external application promotes Wound healing, soybean, Thorn youth fruit, Herba Andrographitis, Poria cocos, Japanese ardisia have anti-inflammation and sterilization effect, avoid infection.By taking 200 patients as an example, the present invention is used Medicine is treated, and 188 patients are effective, and total effective rate is up to 94%；It is effective compared to 82 patients only with oral formulations From the point of view of, effective percentage improves 53%；Compared to the name patient only with external used medicine 65 effectively from the point of view of, effective percentage improves 61.5%.

Embodiment

To make the purpose, technical scheme and advantage of the embodiment of the present invention clearer, below in conjunction with the embodiment of the present invention, Technical scheme in the embodiment of the present invention is clearly and completely described, it is clear that described embodiment is the present invention one Divide embodiment, rather than whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art are not making The every other embodiment obtained under the premise of creative work, belongs to the scope of protection of the invention.

Embodiment 1：

A kind of hydropericardium pharmaceutical composition, it is for oral administration to be made up of the component of following mass fraction：5 parts of alangium, hoary hair 4 parts of father-in-law, 4 parts of radix scutellariae, 7 parts of FLOS CHRYSANTHEMI from Hangzhou of China, yellow grass spend 4 parts, 5 parts of antelope's horn, 5 parts of viola japonica, 5 parts of Verbena officinalis, 1 part of indigo naturalis, mock-strawberry 5 Part, 4 parts of wilsonii, 5 parts of rhodiola root, 5 parts of lily, 4 parts of chorion ovi, 4 parts of oyster；External used medicine by following mass fraction group It is grouped into：5 parts of rhizoma imperatae, 5 parts of Radix Isatidis, 4 parts of wolf's milk, 4 parts of bigfruit phymatopsis herb, 5 parts of moutan bark, 4 parts of menthol, 5 parts of fleabane flower, 5 parts of thyme, 6 parts of Radix Angelicae Sinensis, 7 parts of the bark of official magnolia.

The preparation method of wherein endo-medicine comprises the steps of：

(3) above-mentioned mixed-powder is put into capsule filling machine to be filled, that is, obtains 0.5 gram every of capsule.

The preparation method of external used medicine comprises the steps of：

(1) weigh Chinese medicine material by above-mentioned weight ratio, prior to 6 DEG C under the conditions of refrigerate 18h, at -15 DEG C freeze 15h it is standby With；After freezing, volumetric expansion when being frozen using hydrone, the eucaryotic cell structure of Chinese medicine is directly destroyed, cellular damage rate is improved, is The microwave bulking of next step lays the first stone.

(2) temperature in microwave storehouse is set as 120 DEG C, microwave storehouse is preheated, and then puts into 1.5kg steps (1) freezing Chinese medicine material after processing, regulation microwave power are 500w, and operation 150s carries out microwave bulking；Then it is 75 to adjust temperature first DEG C, power 115w, dry 3min；Then it is 60 DEG C, power 105w to adjust temperature, dries 2min；It is 45 DEG C finally to adjust temperature, Power 95w, dry 3min；Chinese medicine after freezing is directly subjected to microwave bulking, is directly changed into gas from ice using hydrone The strength of moment distillation completes puffing process, does not then have to take out Chinese medicine, is directly dried using microwave, dry mistake In journey open stirring, Chinese medicine during stirring uniform drying and because microwave bulking dry become fragile, in whipping process Naturally disintegrating slag is broken into, beneficial to the crushing in later stage.

(3) Chinese medicine after step (2) processing is put into ball mill and crushed；Further crush can cause medicinal material powder End is homogeneous, and various active ingredients further separate out, beneficial to absorption of human body.Pulverization conditions are just to grind 15min using ball mill After shut down 3min, then shut down 3min after anti-mill 15min, so repeatedly 2 times.

(4) weigh the addition protease of the Chinese medicine material after crushing in proportion to be digested, protease is neutral proteinase；

(5) according to 1:300 solid-liquid ratio soaks ultrafiltration after 20h in ethanol, and the molecular weight of milipore filter retention is 200000；

(6) liquid after ultrafiltration is sealed after microwave disinfection, microwave disinfection condition is 85 DEG C, 120 seconds time.

Embodiment 2：

A kind of hydropericardium pharmaceutical composition, it is for oral administration to be made up of the component of following mass fraction：It is alangium 4-6 parts, white Head father-in-law 3-5 parts, radix scutellariae 3-5 parts, FLOS CHRYSANTHEMI from Hangzhou of China 6-8 parts, yellow grass flower 3-5 parts, antelope's horn 4-6 parts, viola japonica 4-6 parts, Verbena officinalis 4-6 Part, indigo naturalis 1-2 parts, mock-strawberry 4-6 parts, wilsonii 3-5 parts, rhodiola root 4-6 parts, lily 4-6 parts, chorion ovi 3-5 parts, oyster 3- 5 parts；External used medicine is made up of the component of following mass fraction：White back of the body cudweed 4-6 parts, pilosella-leaved drymoglossum herb 4-6 parts, marginate American agave leaf 3- 5 parts, dried rhizome of rehmannia 3-5 parts, cornu bubali 4-6 parts, soybean 5-8 parts, thorn youth fruit 3-5 parts, Herba Andrographitis 3-5 parts, Poria cocos 4-6 parts, Japanese ardisia 4-6 parts.

The preparation method of wherein endo-medicine comprises the steps of：

The preparation method of external used medicine comprises the steps of：

(1) weigh Chinese medicine material by above-mentioned weight ratio, prior to 4 DEG C under the conditions of refrigerate 24h, at -10 DEG C freeze 20h it is standby With；After freezing, volumetric expansion when being frozen using hydrone, the eucaryotic cell structure of Chinese medicine is directly destroyed, cellular damage rate is improved, is The microwave bulking of next step lays the first stone.

(2) temperature in microwave storehouse is set as 110 DEG C, microwave storehouse is preheated, and is then put at 2kg steps (1) freezing Chinese medicine material after reason, regulation microwave power are 450w, and operation 180s carries out microwave bulking；Then it is 70 to adjust temperature first DEG C, power 120w, dry 2min；Then it is 70 DEG C, power 100w to adjust temperature, dries 3min；It is 40 DEG C finally to adjust temperature, Power 100w, dry 2min；Chinese medicine after freezing is directly subjected to microwave bulking, is directly changed into gas from ice using hydrone The strength of moment distillation completes puffing process, does not then have to take out Chinese medicine, is directly dried using microwave, dry mistake In journey open stirring, Chinese medicine during stirring uniform drying and because microwave bulking dry become fragile, in whipping process Naturally disintegrating slag is broken into, beneficial to the crushing in later stage.

(4) weigh the addition protease of the Chinese medicine material after crushing in proportion to be digested, protease is alkali protease；

(5) according to 1:500 solid-liquid ratio soaks ultrafiltration after 12h in ethanol, and the molecular weight of milipore filter retention is 180000；

(6) liquid after ultrafiltration is sealed after microwave disinfection, microwave disinfection condition is 70 DEG C, 180 seconds time.

Embodiment 3：

The preparation method of wherein endo-medicine comprises the steps of：

The preparation method of external used medicine comprises the steps of：

(1) weigh Chinese medicine material by above-mentioned weight ratio, prior to 10 DEG C under the conditions of refrigerate 12h, freeze 10h at -18 DEG C It is standby；After freezing, volumetric expansion when being frozen using hydrone, the eucaryotic cell structure of Chinese medicine is directly destroyed, improves cellular damage rate, Laid the first stone for the microwave bulking of next step.

(2) temperature in microwave storehouse is set as 130 DEG C, microwave storehouse is preheated, and is then put at 1kg steps (1) freezing Chinese medicine material after reason, regulation microwave power are 600w, and operation 120s carries out microwave bulking；Then it is 80 to adjust temperature first DEG C, power 110w, dry 3min；Then it is 50 DEG C, power 110w to adjust temperature, dries 2min；It is 50 DEG C finally to adjust temperature, Power 90w, dry 3min；Chinese medicine after freezing is directly subjected to microwave bulking, is directly changed into gas from ice using hydrone The strength of moment distillation completes puffing process, does not then have to take out Chinese medicine, is directly dried using microwave, dry mistake In journey open stirring, Chinese medicine during stirring uniform drying and because microwave bulking dry become fragile, in whipping process Naturally disintegrating slag is broken into, beneficial to the crushing in later stage.

(4) weigh in proportion crush after Chinese medicine material add protease digested, protease be papain and Trypsase；

(5) according to 1:100 solid-liquid ratio soaks ultrafiltration after 24h in ethanol, and the molecular weight of milipore filter retention is 150000；

(6) liquid after ultrafiltration is sealed after microwave disinfection, microwave disinfection condition is 105 DEG C, 90 seconds time.

Claims

A kind of 1. hydropericardium pharmaceutical composition, it is characterised in that：It is made up of endo-medicine and external used medicine, wherein medicine for oral administration Thing is made up of the component of following mass fraction：Alangium 4-6 parts, Chinese bulbul 3-5 parts, radix scutellariae 3-5 parts, FLOS CHRYSANTHEMI from Hangzhou of China 6-8 parts, yellow grass Flower 3-5 parts, antelope's horn 4-6 parts, viola japonica 4-6 parts, Verbena officinalis 4-6 parts, indigo naturalis 1-2 parts, mock-strawberry 4-6 parts, wilsonii 3-5 parts, Rhodiola root 4-6 parts, lily 4-6 parts, chorion ovi 3-5 parts, oyster 3-5 parts.
2. hydropericardium pharmaceutical composition as claimed in claim 1, it is characterised in that by the component group of following mass fraction Into：5 parts of alangium, 4 parts of the Chinese bulbul, 4 parts of radix scutellariae, 7 parts of FLOS CHRYSANTHEMI from Hangzhou of China, yellow grass spend 4 parts, 5 parts of antelope's horn, 5 parts of viola japonica, Verbena officinalis 5 parts, 1 part of indigo naturalis, 5 parts of mock-strawberry, 4 parts of wilsonii, 5 parts of rhodiola root, 5 parts of lily, 4 parts of chorion ovi, 4 parts of oyster.
3. hydropericardium pharmaceutical composition as claimed in claim 1, it is characterised in that external used medicine is by following mass fraction Component composition：White back of the body cudweed 4-6 parts, pilosella-leaved drymoglossum herb 4-6 parts, marginate American agave leaf 3-5 parts, dried rhizome of rehmannia 3-5 parts, cornu bubali 4-6 parts, Soybean 5-8 parts, thorn youth fruit 3-5 parts, Herba Andrographitis 3-5 parts, Poria cocos 4-6 parts, Japanese ardisia 4-6 parts.
4. hydropericardium pharmaceutical composition as claimed in claim 3, it is characterised in that by the component group of following mass fraction Into：White 5 parts of cudweed of the back of the body, 5 parts of pilosella-leaved drymoglossum herb, 4 parts of marginate American agave leaf, 4 parts of the dried rhizome of rehmannia, 5 parts of cornu bubali, 7 parts of soybean, 4 parts of thorn youth fruit, 4 parts of Herba Andrographitis, 5 parts of Poria cocos, 5 parts of Japanese ardisia.
A kind of 5. preparation method of hydropericardium pharmaceutical composition as claimed in claim 1, it is characterised in that endo-medicine by Following steps form：

(1) bulk drug is weighed by weight to add water to cook twice, add 4 times of amount water every time, decoct 2 hours for the first time, second pan-fried Boil 1 hour, merging filtrate, after filtering, be dried to fine powder；

(2) fine powder in step (1) is added into anhydrous grape Icing Sugar to be well mixed；

(3) above-mentioned mixed-powder is put into capsule filling machine to be filled, that is, obtains every 0.4-0.6 grams of capsule.
A kind of 6. preparation method of hydropericardium pharmaceutical composition as claimed in claim 3, it is characterised in that external used medicine by Following steps form：

(1) weigh Chinese medicine material by above-mentioned weight ratio, prior to 4-10 DEG C under the conditions of refrigerate 12-24h, it is cold at -10~-18 DEG C It is standby to freeze 10-20h；

(2) temperature in microwave storehouse is set as 110-130 DEG C, microwave storehouse is preheated, and then puts into 1-2kg steps (1) freezing Chinese medicine material after processing, regulation microwave power are 450-600w, and operation 120-180s carries out microwave bulking；Then temperature is adjusted Save as 40-80 DEG C, microwave power 90-120w, dry 6-9min；

(3) Chinese medicine after step (2) processing is put into ball mill and crushed；

(4) the addition protease of the Chinese medicine material after crushing is weighed in proportion to be digested；

(5) according to 1:100~1:500 solid-liquid ratio soaks ultrafiltration after 12~24h in ethanol；

(6) liquid after ultrafiltration is sealed after microwave disinfection.
7. the preparation method of hydropericardium pharmaceutical composition as claimed in claim 6, it is characterised in that：The step (2) Stage drying is used after microwave bulking, i.e., it is 70-80 DEG C, power 110-120w to adjust temperature first, dries 2-3min；Then adjust It is 50-70 DEG C, power 100-110w to save temperature, dries 2-3min；It is 40-50 DEG C, power 90-100w finally to adjust temperature, is done Dry 2-3min.
8. the preparation method of hydropericardium pharmaceutical composition as claimed in claim 6, it is characterised in that：The step (3) Pulverization conditions 3min is being shut down after 15Min just to be ground using ball mill, then shut down 3min after anti-mill 15min, so repeatedly 2 times.
9. the preparation method of hydropericardium pharmaceutical composition as claimed in claim 6, it is characterised in that：The step (4) In protease be one or more in alkali protease, neutral proteinase, papain or trypsase.
10. the preparation method of hydropericardium pharmaceutical composition as claimed in claim 6, it is characterised in that：The step (5) The molecular weight of middle milipore filter retention is 15000-20000.