CN107375260B - 靶向癌症干细胞的新的化合物和组合物 - Google Patents

靶向癌症干细胞的新的化合物和组合物 Download PDF

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CN107375260B
CN107375260B CN201710613671.9A CN201710613671A CN107375260B CN 107375260 B CN107375260 B CN 107375260B CN 201710613671 A CN201710613671 A CN 201710613671A CN 107375260 B CN107375260 B CN 107375260B
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compound
polymorph
cancer
furan
naphtho
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CN107375260A (zh
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李嘉强
D.勒格特
李有志
李微
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1Globe Biomedical Co Ltd
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/92—Naphthofurans; Hydrogenated naphthofurans
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    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
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    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

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  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
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CN201710613671.9A 2010-03-19 2011-03-21 靶向癌症干细胞的新的化合物和组合物 Active CN107375260B (zh)

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US31588610P 2010-03-19 2010-03-19
US31589010P 2010-03-19 2010-03-19
US61/315,890 2010-03-19
US61/315,886 2010-03-19
US32581410P 2010-04-19 2010-04-19
US61/325,814 2010-04-19
CN2011800231072A CN103002890A (zh) 2010-03-19 2011-03-21 靶向癌症干细胞的新的化合物和组合物
PCT/US2011/029281 WO2011116398A1 (en) 2010-03-19 2011-03-21 Novel compounds and compositions for targeting cancer stem cells
CN201710613671.9A CN107375260B (zh) 2010-03-19 2011-03-21 靶向癌症干细胞的新的化合物和组合物

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CN201710665153.1A Active CN107721958B (zh) 2010-03-19 2011-03-21 靶向癌症干细胞的新的化合物和组合物
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CN2011800231072A Pending CN103002890A (zh) 2010-03-19 2011-03-21 靶向癌症干细胞的新的化合物和组合物

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CN (3) CN107375260B (enExample)
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NZ602328A (en) * 2010-03-19 2014-11-28 Boston Biomedical Inc Novel compounds and compositions for targeting cancer stem cells
CN104016951B (zh) * 2010-03-19 2016-07-13 北京强新生物科技有限公司 靶向癌症干细胞的化合物和组合物
US20160030384A1 (en) * 2013-04-09 2016-02-04 Boston Biomedical, Inc. 2-acetylnaphtho[2,3-b]furan -4,9-dione for use on treating cancer
CN106163284A (zh) * 2014-02-07 2016-11-23 北京强新生物科技有限公司 3‑取代的羰基萘并[2,3‑b]呋喃衍生物或其药学上可接受的盐
EP3153508B1 (en) 2014-06-09 2020-03-18 Kyoto Pharmaceutical Industries, Ltd. Naphthofuran derivatives for use as anticancer agents
WO2016168857A1 (en) 2015-04-17 2016-10-20 Boston Biomedical, Inc. Methods for treating cancer
JP2018511643A (ja) 2015-04-17 2018-04-26 ボストン バイオメディカル, インコーポレイテッド 癌を治療するための方法
WO2016196935A1 (en) * 2015-06-03 2016-12-08 Boston Biomedical, Inc. Compositions comprising a cancer stemness inhibitor and an immunotherapeutic agent for use in treating cancer
US10329267B2 (en) 2015-07-17 2019-06-25 Sumitomo Dainippon Pharma Co., Ltd. Method for producing 2-acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione
WO2017079864A1 (en) * 2015-11-12 2017-05-18 Hangzhou Yier Biotech Co., Ltd. Treatment of cancers related to chronically active ras
WO2017132049A1 (en) 2016-01-20 2017-08-03 Boston Biomedical, Inc. Methods for treating cancer
WO2017160978A1 (en) 2016-03-15 2017-09-21 Boston Biomedical, Inc. Cell cultures and use thereof
WO2018005444A2 (en) 2016-06-28 2018-01-04 Boston Biomedical, Inc. Methods for treating cancer
WO2018098352A2 (en) 2016-11-22 2018-05-31 Jun Oishi Targeting kras induced immune checkpoint expression
CA3045306A1 (en) 2016-11-29 2018-06-07 Boston Biomedical, Inc. Naphthofuran derivatives, preparation, and methods of use thereof
JP2020512377A (ja) 2017-03-30 2020-04-23 ボストン バイオメディカル, インコーポレイテッド がんを処置および/または防止するための組成物
JP2020520923A (ja) 2017-05-17 2020-07-16 ボストン バイオメディカル, インコーポレイテッド がんを処置するための方法
MX2021004151A (es) 2018-10-12 2021-09-08 1Globe Biomedical Co Ltd Nueva solución de combinación para el tratamiento contra cáncer refractario a la quimioterapia.

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JPH1121284A (ja) 1997-06-30 1999-01-26 Kotobuki:Kk フラノナフトキノン誘導体及びこれを含有する医薬
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WO2009036099A1 (en) * 2007-09-10 2009-03-19 Boston Biomedical, Inc. A novel group of stat3 pathway inhibitors and cancer stem cell pathway inhibitors

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CA2946899A1 (en) 2011-09-22
US20130034591A1 (en) 2013-02-07
KR101714819B1 (ko) 2017-03-09
CN107375260A (zh) 2017-11-24
CA2793526C (en) 2018-05-01
RU2012144421A (ru) 2014-04-27
SG184063A1 (en) 2012-10-30
AU2016200953A1 (en) 2016-03-03
CA2793526A1 (en) 2011-09-22
ES2659541T3 (es) 2018-03-16
KR101908208B1 (ko) 2018-10-15
WO2011116398A1 (en) 2011-09-22
CN107721958A (zh) 2018-02-23
AU2011227022C1 (en) 2016-04-21
US20150183756A1 (en) 2015-07-02
CN103002890A (zh) 2013-03-27
US20180193303A1 (en) 2018-07-12
JP5602935B2 (ja) 2014-10-08
MX370721B (es) 2019-12-20
DK2547334T3 (en) 2018-02-19
BR112012023661A2 (pt) 2020-11-24
AU2011227022B2 (en) 2015-11-19
MX394137B (es) 2025-03-24
BR122021025776B1 (pt) 2022-12-27
AU2016200953B2 (en) 2017-07-27
KR20130056227A (ko) 2013-05-29
RU2571661C2 (ru) 2015-12-20
NZ602328A (en) 2014-11-28
MX2012010434A (es) 2013-01-29
EP2547334B1 (en) 2017-11-15
EP2547334A1 (en) 2013-01-23
US9084766B2 (en) 2015-07-21
JP2013522325A (ja) 2013-06-13
US9381184B2 (en) 2016-07-05
KR20160135375A (ko) 2016-11-25
AU2011227022A1 (en) 2012-09-27
CA2946899C (en) 2018-03-06
US20160271099A1 (en) 2016-09-22
EP2547334A4 (en) 2013-08-14
CN107721958B (zh) 2024-08-23

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