CN107375260B - 靶向癌症干细胞的新的化合物和组合物 - Google Patents

靶向癌症干细胞的新的化合物和组合物 Download PDF

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CN107375260B
CN107375260B CN201710613671.9A CN201710613671A CN107375260B CN 107375260 B CN107375260 B CN 107375260B CN 201710613671 A CN201710613671 A CN 201710613671A CN 107375260 B CN107375260 B CN 107375260B
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compound
polymorph
cancer
furan
naphtho
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CN107375260A (zh
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李嘉强
D.勒格特
李有志
李微
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1Globe Biomedical Co Ltd
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • CCHEMISTRY; METALLURGY
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    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/92Naphthofurans; Hydrogenated naphthofurans
    • AHUMAN NECESSITIES
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    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]

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  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
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  • Gynecology & Obstetrics (AREA)
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  • Diabetes (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
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CN201710613671.9A 2010-03-19 2011-03-21 靶向癌症干细胞的新的化合物和组合物 Active CN107375260B (zh)

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CN201710613671.9A CN107375260B (zh) 2010-03-19 2011-03-21 靶向癌症干细胞的新的化合物和组合物

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US31588610P 2010-03-19 2010-03-19
US31589010P 2010-03-19 2010-03-19
US61/315,890 2010-03-19
US61/315,886 2010-03-19
US32581410P 2010-04-19 2010-04-19
US61/325,814 2010-04-19
PCT/US2011/029281 WO2011116398A1 (en) 2010-03-19 2011-03-21 Novel compounds and compositions for targeting cancer stem cells
CN201710613671.9A CN107375260B (zh) 2010-03-19 2011-03-21 靶向癌症干细胞的新的化合物和组合物
CN2011800231072A CN103002890A (zh) 2010-03-19 2011-03-21 靶向癌症干细胞的新的化合物和组合物

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CN107375260B true CN107375260B (zh) 2023-10-24

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CN201710665153.1A Active CN107721958B (zh) 2010-03-19 2011-03-21 靶向癌症干细胞的新的化合物和组合物
CN201710613671.9A Active CN107375260B (zh) 2010-03-19 2011-03-21 靶向癌症干细胞的新的化合物和组合物

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CN201710665153.1A Active CN107721958B (zh) 2010-03-19 2011-03-21 靶向癌症干细胞的新的化合物和组合物

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EP (1) EP2547334B1 (enExample)
JP (1) JP5602935B2 (enExample)
KR (2) KR101908208B1 (enExample)
CN (3) CN103002890A (enExample)
AU (2) AU2011227022C1 (enExample)
BR (2) BR122021025776B1 (enExample)
CA (2) CA2946899C (enExample)
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ES (1) ES2659541T3 (enExample)
MX (2) MX394137B (enExample)
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RU (1) RU2571661C2 (enExample)
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HUE027443T2 (en) 2007-09-10 2016-10-28 Boston Biomedical Inc A novel class of Stat3 pathway inhibitors and tumor stem cell inhibitors
SG10201704745UA (en) * 2010-03-19 2017-07-28 Boston Biomedical Inc Novel compounds and compositions for targeting cancer stem cells
CN103002890A (zh) * 2010-03-19 2013-03-27 波士顿生物医学公司 靶向癌症干细胞的新的化合物和组合物
JP6433085B2 (ja) * 2013-04-09 2018-12-05 ボストン バイオメディカル, インコーポレイテッド がんの処置に使用するための2−アセチルナフト[2,3−b]フラン−4,9−ジオン
WO2015120304A1 (en) * 2014-02-07 2015-08-13 Boston Biomedical, Inc. 3-substituted carbonyl-naphtho[2,3-b]furane derivative or pharmaceutically acceptable salt thereof
WO2015190489A1 (ja) 2014-06-09 2015-12-17 京都薬品工業株式会社 新規抗癌剤
SG11201708504XA (en) 2015-04-17 2017-11-29 Boston Biomedical Inc Methods for treating cancer
HK1250942A1 (zh) 2015-04-17 2019-01-18 Boston Biomedical, Inc. 用於治疗癌症的方法
EA201792623A1 (ru) 2015-06-03 2018-04-30 Бостон Биомедикал, Инк. Композиции, содержащие ингибитор стволовости рака и иммунотерапевтический агент, для применения в лечении рака
WO2017013865A1 (ja) 2015-07-17 2017-01-26 大日本住友製薬株式会社 2-アセチル-4H,9H-ナフト[2,3-b]フラン-4,9-ジオンの製造方法
WO2017079864A1 (en) * 2015-11-12 2017-05-18 Hangzhou Yier Biotech Co., Ltd. Treatment of cancers related to chronically active ras
JP2019506392A (ja) 2016-01-20 2019-03-07 ボストン バイオメディカル, インコーポレイテッド がんを処置するための方法
WO2017160978A1 (en) 2016-03-15 2017-09-21 Boston Biomedical, Inc. Cell cultures and use thereof
WO2018005444A2 (en) 2016-06-28 2018-01-04 Boston Biomedical, Inc. Methods for treating cancer
WO2018098352A2 (en) 2016-11-22 2018-05-31 Jun Oishi Targeting kras induced immune checkpoint expression
US11299469B2 (en) 2016-11-29 2022-04-12 Sumitomo Dainippon Pharma Oncology, Inc. Naphthofuran derivatives, preparation, and methods of use thereof
CA3058162A1 (en) 2017-03-30 2018-10-04 Boston Biomedical, Inc. Compositions for treating and/or preventing cancer
WO2018213424A1 (en) 2017-05-17 2018-11-22 Boston Biomedical, Inc. Methods for treating cancer
EP3865130A4 (en) 2018-10-12 2022-07-20 1Globe Biomedical Co., Ltd. NEW COMBINATION SOLUTION FOR THE TREATMENT OF CHEMOTHERAPY-REFRACTORY CANCER

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JPH1121284A (ja) 1997-06-30 1999-01-26 Kotobuki:Kk フラノナフトキノン誘導体及びこれを含有する医薬
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WO2009036099A1 (en) * 2007-09-10 2009-03-19 Boston Biomedical, Inc. A novel group of stat3 pathway inhibitors and cancer stem cell pathway inhibitors

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JP2013522325A (ja) 2013-06-13
AU2011227022C1 (en) 2016-04-21
US20130034591A1 (en) 2013-02-07
ES2659541T3 (es) 2018-03-16
KR101908208B1 (ko) 2018-10-15
BR122021025776B1 (pt) 2022-12-27
CA2946899C (en) 2018-03-06
RU2571661C2 (ru) 2015-12-20
CA2793526A1 (en) 2011-09-22
CA2946899A1 (en) 2011-09-22
MX2012010434A (es) 2013-01-29
CN107721958B (zh) 2024-08-23
RU2012144421A (ru) 2014-04-27
KR20130056227A (ko) 2013-05-29
EP2547334A4 (en) 2013-08-14
CN103002890A (zh) 2013-03-27
EP2547334A1 (en) 2013-01-23
WO2011116398A1 (en) 2011-09-22
MX370721B (es) 2019-12-20
KR20160135375A (ko) 2016-11-25
US20150183756A1 (en) 2015-07-02
EP2547334B1 (en) 2017-11-15
JP5602935B2 (ja) 2014-10-08
US9084766B2 (en) 2015-07-21
SG184063A1 (en) 2012-10-30
NZ602328A (en) 2014-11-28
US20180193303A1 (en) 2018-07-12
DK2547334T3 (en) 2018-02-19
CN107375260A (zh) 2017-11-24
CA2793526C (en) 2018-05-01
AU2011227022A1 (en) 2012-09-27
AU2011227022B2 (en) 2015-11-19
US20160271099A1 (en) 2016-09-22
BR112012023661A2 (pt) 2020-11-24
AU2016200953A1 (en) 2016-03-03
US9381184B2 (en) 2016-07-05
KR101714819B1 (ko) 2017-03-09
CN107721958A (zh) 2018-02-23
AU2016200953B2 (en) 2017-07-27
MX394137B (es) 2025-03-24

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